Document pm4dZVQkYk65YDgM5R0BOnowX

| ip 3M AR SSaief VriemPasntn, 22 i097 nMaSiafetymSerovesamon, - BRE Buoilndianng 4v22e6e.36 TH EYL PSUPO BorM33N531S533: 86HR _ 80. 00373 EMAL CERTIFI! IL May 29,2002 SEHR -06--00. 032 73 ConNtga;in Nocg US EPA Document Processing Center (7407M) EPA East -- Room 6428 Attn: Section 8() Office ofPollution Prevention and Toxics 1200 Pennsylvania Ave., NW `Washington, DC 20460-0001 8= cg== 5g33=88 2 33 >= 89 2 MTeStChyAl8p(eEr)flSuUoBroSoTctAaNneTsIuAlfLonRaImSidKeNsaOlTt ICE ON: triphenylbenzyl phosphonium cation/N- Dear Sir: bilirubin, urea and alanine/aspartate aminotransferase activity values, The low dose group. 3M has received draft study results pertaining to a rat 28 day oral gavage study with triphenylbenzyl phosphonium (TPBP) cation/N-Methyl perfluorooctanesulfonamide salt (PMN 88-141) that indicate this compound to have significant toxicity. The study was conducted in accordance with OECD 407, Repeated Dose 28-Oral Toxicity in Rodents and EEC Directive 96/S4/EEC, B.7 Repeated Dose (28 days) Toxicity (Oral) guidelines,by. NOTOX Laboratories. The rats dosed with 50 or 150 mg/kg triphenylbenzylphosphonium cation/N-Methy] perfluorooctanesulfonamide salt all died or were euthanized in moribund pcohnodsipthioonnibuymthceateinodno/fN-sMteutdhyylwepeerkf3i.uoRraotosctdaonseesdulwfiotnham1i5demgsa/lktgsturrivpihveendytlhbeensztyuldy but were found to have moderate hepatocellular hypertrophy, increased liver weights, decreasedspleen and terminal body weights, reduced cholesterol and inorganic phosphate levels, increased animals (S mg/kg) had slightly increased liver weights and minimal {o slight hepatocellular r`heysppeorntsreopahnyd. (NOAEL). tThihsedmoislediesfbfeelctisevoebdsetorvreedpraetsetnhte a5 Nmog/Okbgsdeorsveaabrlee AcdovnesirdseerEefdfeacnatdLaepvteilve A copyof this study report will be sent to EPA when received. `This material is used as a curative at low concentration (<2%) in many fluoroelastomer cproomdpuocntesnutnodfemriwxetlulr-ceosntrolled industrial hygiene practices. It is only distributed as a minor 2 = == o3w3 5382 zoz== 5 F <o Boi- Kood iovnarisuts Please contact Dr. Larry R. Johnson, 3M Corporate Toxicology, 651-733-9218, for further information. Katherine E. Reed StaffVice President, Environmental Technology and Safety Services !