Document pm2pMZG7pVaXnLb1pwGqNvjKB

Januai-y T C p 1946 Mr. 1 . C. K o b erts, Aluminum Or a Company , E ast St'. L o u is, I l l i n o i s . L e a r Mi-. K obert s : I n t h e a b s e n c e o f D r . Kehoe from th e L a b o ra to ry I am fo r w a r d in g to you under se p a r a te c o v er two s e t s o f c o n ta in e r s f o r th e c o l l e c t i o n o f blood and u rin e sam ples in accordan ce w ith your l e t t e r o f January 14. The equipment I have se n t fo r th e c o lle c t io n o f th e blood sam ples i s a new type o f c o n ta in e r su p p lie d by E ecto n and D ic k in s o n . I t seem s l i k e l y t h a t th e doctor* who w i l l ta k e th e b lo o d sa m p les w i l l n o t have seen any o f th ese tu b es p r e v io u s ly , and th e r e fo r e I t seems d e s ir a b le to senyou rather* d e t a ile d in s t r u c t io n s f o r t h e ir u s e . F o r t h a t r e a s o n I e n c l o s e h e r e w it h a memorandum g i v i n g su c h i n s t r u c tio n s which I th in k w ill be found to be ad eq u ate. I t i s our b e lie f th at the o p p o r tu n itie s fo r contam ination o f blood sam ples fo r lead d eterm in a tio n taken by t h is means w ill be sub s t a n t i a l l y n e g l i g i b l e . However-, i t seem s a d v is a b le to prove the p o in t t o ou r m u tu a l s a t i s f a c t i o n inasm uch a s we may be d e a l in g w ith sa m p le s w h ich i n any c a s e may h a v e im p o r ta n t m e d i c o - l e g a l r e l a t i o n sh ip s . fo r th is reason i t is d esira b le fo r the doctor to obtain two sam ples in each in s ta n c e o f a t l e a s t lu c - c . e a c h . W ith a l i t t l e c a r e I b e l i e v e i t w i l l be p o s s i b l e to o b t a in two sam p les w ith o u t rem oving th e n e e d le from th e v e in , m erely s h if t in g i t from one tube to the o th e r . I am e n c l o s i n g an e x t r a copy o f t h i s l e t t e r fox* y o u r c o n v e n ie n c e i n fo r w a r d in g t h i s in f o r m a tio n t o D r . I r w in or* w h oever w i l l b e ta k in g the sam ples. Very tr u ly y o u rs, ef Enc. E . 1.7 F or t l a g e , S e c r e ta r y to D r. Kehoe b( 0005291 Aluminum Or? Gomptmu, fo. January 14, 1946 Dr. Robert A. Kehoe K etterin g Laboratory o f A pplied P hysiology C o lleg e o f M edicine, Lden Avenue University of C in cin n a ti C in c in n a ti 1 9 , Ohio Dear Dr. Kehoe: September 4, 1945 your is boratory an alyzed one of our em ployees fo r b lo o d -lea d and u r in e -le a d . Based on the r e s u lt s of th ese a n a ly ses th is em ployee i s s t i l l being used on non-exposure work. I f i t i s c o n v e n ie n t a t t h i s tim e we would l i k e to have t h i s man r e c h e c k e d and a l s o have one o t h e r man a n a ly z e d who has been doing lead burning for the p ast s ix m onths. W ill you k in d ly fu r n is h us w ith the n e c e ssa r y s t e r i l e n e e d le s and sp ecim en b o t t l e s f o r th is w ork . We assum e t h a t you r f e e fo r t h e s e a n a ly s e s is $10.00 as in previous c a se s. At the tim e th a t you were in S t. L ouis for the In d u str ia l Hygiene m eetin g, I was c a ile d to C hicago. I t was w ith a g r e a t d eal of r e g r e t th a t I had to m iss your sp len d id t a lk . However, one o f our men a tte n d e d th e m e e tin g and p rep ared a f u l l summary o f you r t a l k . We found t h i s to be v e r y i n s t r u c t i v e and i n t e r e s t i n g . I hope a t soxae f u t u r e d a te I w i l l have th e p r i v i l e g e o f h e a r in g you. Very tru ly y o u rs, R C. Roberts RCIMAK X X 0005292 Aluminum On Gompnnu, September 6, 1945 Dr. Robert A. Kehoe, D irecto r K etterin g Laboratory o f A pplied P hysiology C o lle g e of M ed icin e, Kden Avenue U n iversity o f C incinnati C in c in n a ti 1 9 , Ohio Dear Dr. Kehoe: We h ave y o u r l e t t e r o f Septem ber 4 e n c lo s in g a n a ly s e s of sam p les o f u rin e and b lood on one o f our e m p lo y e e s. You sh o u ld r e c e i v e a check v e r y s h o r t ly covering expenses in volved in th ese a n a ly ses. I t i s g r a t i f y i n g to us to know th a t t h e b lood -lead i s slow ly tap erin g o ff to normal le v e l. As you s u g g e s t in you r l e t t e r t h i s man w i l l n o t be returned to h is p reviou s occu p ation u n t il such tim e a s h i s b lo o d l e v e l h a s dropped to .05 mg p er 100 gram s. In th e m eantim e, we have made e x t e n s iv e changes t o improve v e n t ila t io n so th a t th ere w i l l not be, a r e o c c u r e n c e o f t h i s t r o u b l e . With y o u r p e r m is s io n we w ould l i k e to check t h i s man a g a in i n abou t th r e e m onths. A gain we a p p r e c ia te your c o o p e r a tio n in t h i s problem . Very tr u ly yours, R. C. R o b e r ts RCR:AK . CC: Dr. D. A. I r w in , A lc o a M ed ica l D ir e c to r 000529 N 7304.02 Sep tem b er 8 , 19^5 M r. I. . C R o b e r t s , Aluminum Ore Company, E ast S t. L ou is, I llin o is . D e a r Mr . R o b e r ts : Thank you f o r c a llin g ; a t t e n t io n to th e e r r o r 021 th e a n a l y t i c a l r e p o r t o f W t t K K M t K t t t K K K k ' a t tach ed to my l e t t e r o f Septem ber H. You a r e c o r r e c t i n t h a t th e r e p o r t sh o u ld h a v e read M g.P b / l o t prams o f blood . I r e g r e t th at th is ty p o g ra p h ica l erro r slip p ed by u n n o ticed . Very tr u ly y o u r s, R ob ert A . K eh o e , M. D . ef K f 0005284 N 7304.03 Aluminum Ot? Gompunu, September 7 , 1945 D r. R ob ert A. K eiioe, D ir e c t o r K etterin g Laboratory of A pplied Physiology C o lleg e o f M edicine-Sden Avenue U n iversity o f C incinnati C in c in n a ti 19, Ohio Dear Dr. K ehoe: Regarding the a n a ly tic a l rep ort attach ed to your l e t t e r o f Septem ber 4 c o v e r in g b lood and u r in e a n a ly s e s , we n o te under blood a n a ly s is th a t th e r e s u l t s a r e e x p r e s s e d i n Mg. P b / L i t e r . We wonder i f t h i s sh o u ld n o t c o r r e c t l y rea d Mg. P b /1 0 0 g ra n s o f H o o d . Vie have i n t e r p r e t e d th e r e s u l t s to mean t h i s but w ish to be sui* e th at th is i s the case. Very tr u ly you rs, R. C. R o b e r ts RCR :AK CC: D r. D . A. Ir w in - A lc o a M ed ical D ir e c to r X ? 0005295 N 7304.04 Sep t em b er ' *t , Mr. r . C. B o b e r ts, Aluminum Ore Company, B ast S t. L ou is, I llin o is . Dear Mr. R ob erts: I am se n d in g you h e r e w ith a r e p o r t on th e r e s u l t s o b ta in e d In th e a n a l y s is o i samp le s o i u r in e and B lood on your e m p lo y ee , P I H H H flH I H lfe - ^ en clo se a lso a b i l l in d u p lica te in accordance w ith your req u est. i'ou V i 11 n o te th a t th e u rin a ry lea d c o n c e n tr a tio n In t h is man*s case has dim inished q u ite a p p reciab ly, the con cen tration in the blood on th e o th er hand has dropped only s lig h t ly . . t h is b eh a v io r i s not. un usual in th e c a se o f in d iv id u a ls vho have had con sid erab le lead exposure over a f a ir ly prolonged period . th ere i s a tendency fo r the urinary lead eoneentra lio n to drop more ra p id ly than the blood c o n c e n tr a tio n , but th ere i s a ls o a ten d e n c y l o r th e u r in a r y le a d l e v e l s t o vary uj> and down d u rin g t h is p e r io d . So lon g as b lood le v e ls are as h ig h as they are a t p r e s e n t, i t can be a n tic ip a te d th at sam ples c l u r in e from tim e to tim e w i l l show h ig h c o n c e n tr a tio n s . In o th er w ords th e u r in e sa m p les w i l l v a r y up and down w h ile th e b lo o d v i l s lo w ly ta p e r o i l t o n orm al l e v e l s . th u s by m ere chance- we have ob tain ed a low r e s u lt on t h is o c ca sio n in the u r in e . th e d isp o s i t i o n o i t h i s man sh o u ld be d e te r m in e d i n t h i s c a s e by th e blood le v e l,w h ic h I s abnorm ally h ig h . C onsidering h is h isto r y I t i s my f e e l i n g t h a t h i s e x p o su r e sa o u id be d is c o n t in u e d u n t i l such a tim e as h is blood le v e ls have dropped a t le a s t as fa r as G .u5 m g s. p e r lu o g r a m s. In term s o f c u r r e n t p r a c t i c e t h i s may be lea n in g over backwards to be s a f e , but th is i s vh at I do in th e c a s e o f men f o r whom I h a v e m e d ic a l r e s p o n s i b i l i t y . Very tr u ly yours , BAM e f Enc. B o b e r t A . K eh o e, M- D . K ? 0005296 N 7304.05 Sam ples o f u r in e and b lo o d r e c e i v e d from th e Aluminum Orb Company, E a st S t . L o u is, M isso u r i, f o r le a d a n a ly s e s . U rin e A n a ly s is Number = 1|5A-ii-57^4- Volume = 100 m l. Mg. P b /L it e r = O.O B lo o d A n a ly s is Number crams Mg. Pb/fefebeoi. l4.5A-J4.575 Spec trograp h ic l.5 0.08 D ithizone 19.0 0.07 K f 000529? Sample C o lle c te d : Sample R eceiv ed : Sample R eported: 8 --2/4.--.5 8-27-li5 8--31--4.5 N 7304.06