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CANCER PREVALENCE IN SUBJECTS EXPOSED TO PERFLUOROOCTANONIC ACID (PFOA)
# James Dahlgren M D 1, Ayman B Ibrahim M D `" " \ Raphael W arshaw', Harpreet Takhar MPH
1. UCLA School of-Medicine. 2. Comprehensive Health Screening Services. 3. Dahlgren Medical Group
Please address correspondence to: James Dahlgren, MD 2811 Wiishire Blvd. Santa Monica, CA 90403 Voice: 310-449-5525 ext. 226 FAX: 310-449-5526 dahleren'rzenvipotoxicoiosv.com
K ey w o rd s: PFOA. FFOS, PFAS, CS, cancer, prevalence, environmental, exposure, fluorochemicais Session: Perfluorinated substances
Perfluorooctanonic Acid (PFOA) is a man-made perfiuorooctaned chemical, which is also referred to as CS. PFOA is a key ingredient agent in the production o f TeflonE: and other tluorochemicai products and is biopersistent and bioaccumulates. There has been documented chronic exposure to PFOA of the residents near a plant using PFOA and other fluorinated contaminants.
Our aim was to compare cancer distribution and cancer prevalence rates in a PFOA-exposed population (residents) to that o f the industry cancer registry data from an occupational exposed population and finally to the general population (SEER). We perform ed a questionnaire on 599 residents living near a PFOA using manufacturing plant operated by Dupont. Cancer registry data from the PFOA Dupont workers was made available through discovery in pending litigation against Dupont and was not previously made available to the scientific community for review. The SEER data was used for comparison to the general population.
The overall cancer prevalence rate is higher in the PFOA-exposed population when compared to the general population. Comparison o f cancer prevalence rates for the industry' cancer registry data, resident data and SEER is shown in Table 1.
Our findings indicate that the PFOA exposed residential population and PFOA.-exposed workers have elevated cancer prevalence (Table 1). Prostate cancer in the residents was proportionately elevated among young age males. Cervix and uterine cancer rates in women were also higher in the resident population compared to the U.S. general population.
The distribution o f cancers in the residents and workers is different than expected. O f nte are the findings o f elevated prevalence rates o f atypical cancers such as Non-Hodgkin's, Leukemia, and Multiple M yeloma,
This data suggests that exposure to PFOAJmay alter cancer distribution in exposed populations (worker and residents) and may be an important risk factor for an excess o f cancer cases.
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Tabic 1. Total Prevalence .Rates in Dupont Study, Resident Population, and US Population
tv
Type of Cancer Cancers
Bladder
10
Bone
2
Brain
6
Breast
5
Cervix/Uleri
1
Colon & Rectum
32
Esophagus
3
Hodgkin's
4
Kidney
10
Larynx
' v r>
Oral Cavity
11
Leukemia
11
Liver
4
Lung
64
Melanoma
17
Myeloma
9
Non Hodgkin's
9
Pancreas
9
Prostate
19
Slomach
2
Testicular
r>
Niyroid
3
IOIAI.
304
Dupon! Study Population
5523 5523 5523 . 1034"'' 1034 5523 5523 5523 5523 5523 5523 5523 5523 5523 5523 5523 5523 5523 4409 5523 4409 5523 5523
Rate 0.33% 0.04% 0.11% 0.40% 0.00% 0.58% 0.05% 0.07% 0.33% 0.11% 0.20% 0.20% 0.07% 1.16% 0.31% 0.16% 0.16% 0.16% 0.42% 0.04% 0.11% 0.05% 5.50%
Resident Data Cancers Population Rate
5 599 0.03% 1 599 0.17% - 0 599 0.00% 6 303 1.90% 14 303 4.62% 7 599 1.17% 0 599 0.00% 2 599 0.33% 3 599 0.50% 0 599 0.00% 2 599 0.33% 2 599 0.33% 1 599 0.17% 7 599 1.17% 4 599 0.67% 2 599 0.33% 6 599 1.00% 0 599 0.00% 9 296 3.04% 1 599 0.17% 0 296 0.00% I 599 0.17% 73 599 12.19%
U.S. Data Dupont: US Resident: US
Rale
Ratio
Ratio
0.11%
2.96
7.59
0.01%
3.62
16.69
0.02%
5.43
0.00
0 .8 7 %
0.56
2.20
0.06%
0.00
77.01
0.22%
2.63
5.31
0.00%
0.02%
3.62
16.09
0.05%
6.52
10.02
0.02%
5.43
0.00
0.05%
3.98
6.G0
0.04%
4.9
0.35
0.00%
0.09%
12.00
12.90
0.12%
2.57
5.56
0.01%
16.30
33.39
0.00%
2.04
12.52
0.01%
16.30
0.00
1.16% .
0.36
2.62
0.01%
2.59
11.92
0.05%
2.23
0.00
0.05%
1.09
3.34
3.10%
1.70 t 3.93
rm-
C/O
o
CO
