Document pevk2mQvL6j51bBan5ejoGXpD

' FEDERAL SECURITY AGEN CY . Publ ic Hsalih Service NATIONAL INSTITUTES OF HEALTH Bef fresa a f 4, M d , NATIONAL INSTITUTE, ,0,F ARTHRITIS AND METApOLlC DISEASES NATIONAL CNCER TN Sr iT E, ' NATIONAL, i N S i m f e O E/D fNTL RESEARCH '' NATIONAL HART, INSTITUTE NATIONAL,: l^ p T T U lt .W iN p iffA L HEALTH ' NATIONAL MKROBIOiOlcAL INSTITUTE NATIONAL, ITSTiTOTti;^!'1'f^RpLOGSCI. DISEASES AND BUNDNESS THE CNICA'L CEHt | B s , DI VI SI ON o f r eseA&CM GRANTS A p r il 6 , 1953 Dr, iiob er t A. Kehoe Ketterin g In st it u t e (U n iv e r sit y o f C in cin n at i Campus) C in c in n a t i, Ohio Dear Dr . Keh oe: ou ld you k in d ly sen d me a copy o f a v a il a b l e r e p r in t s o f your p ap er s on t h e ab so r p t io n an d e xcr e t io n o f le a d ? I am e sp e c i a l l y in t e r e st e d in th e p r o p o r t io n of, r e t a in e d le a d t h a t i s e xc r e t e d d a il y when th e, in t ak e ,,h as been sm all amounts over a period of tim e. Vie a r e at t em p t in g t o d evelop a method f o r m easu rin g th e r a d io le a d con ten t of u r in e and fe c e s t o be u sed a s an in d ex of radon e xp o su r e . The rad on in h ale d w il l soon become r a d io le a d by r ad io act iv e decay. Th is r ad iolead w ill th en behave e xact ly as st ab le lead does in th e body. Prelim in ary t e st s in d icate t h a t t h e ext r em ely sm all amounts o f r a d io le a d t h a t a r e m easur ab le w ill give u s a very se n sit iv e t e s t . For t h is t e st t o be ver y u se fu l we must know \vhat a given e xc r e t io n o f le a d means in term s o f body con ten t. Do you , p e r h ap s, h ave some u n p u b lish ed d a t a p e r t in e n t to t h is poin t? Yours v e r y t r u l y , V ic t o r S . A r ch er , M.D. Laboratory o f P h ysical Biology N ation al I n st it u t e o f A r t h r it is M etabolic D iseases HE 0019715