Document peao9rOem6EMayRZjLVvO4QyE
FILE NAME DuPont DUP
DATE 1949
DOC DUP193
DOCUMENT DESCRIPTION Book Excerpt - Industrial Toxicology Referenced in BC report on DuPont DUP000
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MEDICAL
of
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BOK IndustrialCaLlifoornsia,CoLnsuoltsan,Medicne,MaschuetsPthysoican Harvard Asitan
HARIET PAUL
REVISED
B.
New
SECOND
DEPARTMN HARDY, Profesn\Emitu ALICE\|HMLTON, Maschuets YorkOF HOEBR, fiANDEDITON
ENLARGED Ocupationl HARPER INC.
&
ee
THE
SEN BROTHES oy oF
Hygien,Alamos, Alamos
the
Departmen
Schol
of
Boston, Harvard NewScientifc
of Divsion L.
Labor
and
Public
Mas. Schol Mexico; Genral and of Health,of
of
Public
Instruc
or,
Labor
t
y,
Hospital,
Industries;
MEDICAL MEDICAL
Health,DepartmentUniversityBoston; AsitanHygien, M.D. Mas.Medicne M.D.
of
Harvard
of
v
1949 ACADEMY
)
'
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treamnt formerly Tulipan, Health, White, J.
and H. their For and this
J.
to
B.
CONTENTS
matergose CONTES CONTENTS of and
CONTENTS CONTES Skiner.Foulger; gratiude valuble Fourth R. to
CONTENTS
or
skin
Second Howevr, D. Second Preface
Preface Preface EditonEditon Maryland. voluminosResarch Second disease Preface Evans; Introduction H.
Second Introduction Introduction
Introduction authors Industrial M. 1. Diagnosis Diagnosis Diagnosis K. Poisoning
R.
chemicals, records Industrial 2. Alkalies Alkalies Acids Industrial Poisonig
Company,Industrial Poisnig Chromium Mayers; Lead AMlkearciuesry SEedictonodn reader Teleky 3 Lead H. 4. B. 5. Mercury
6.
Chromium and of dealt
by
the is with
Louis Skin only
bilographic Telky Phosphorus refred Nationalinquire Elkins; Holt
7. Phosphorus
by
to
before. to the
as
vi
field
the
there
of
of
are
the the
newr almost the thre
to
times
as
For of make
of
these
no many
the the animal claim
to
an
Holt Phosprus Phosphorus expriments Manges Manges London, Fever Zinc Manges 9.AntimonyAntimony Fume HAMILTON Ana 8. Cadmium Cadmium
R.
The
Antimony
Holt;
Metal Metal Fume Fever
is
Manganese
of Manganese
P
-
81.
19. 18, 7.
Asphyxiants: Turpentie, Chlorinated Phosprus Tar Series Antimony,Selnium, Berylium Cadmiu Coal Aromatic Aromatic Aromatic Aromatic Aromatic Hydrogen Carbon The
Petroleum, DerivatesDiphenyls Cyanides, carbons,Methyl Series
Naphtylmines, Telurim, Hydrogen Naphtylamines Tobaco Iodide Faty,
Hydrocabns, (Contiued): (Contiued):(ContiuedToluen vii
Dyes Chlorinated Monxide, Vandium, Faty Aliphatic Benze, Bromine Benzen Sulphide Series Anilne
Derivates MangesAlumin, Toluen Dyes
16,
4. 18, 12. ll. 10). CEN Asphyxiants Asphyxiants Carbon
and
Nickel
14. Cyanides
and
Series Series Series: Other Metal
Series (
of
Coal Carbon Metals Fume
Tar,
):
Fever,
and
Zinc,
Xylene, or Carbon
and Benzol
Monoxide
Benzene
Continued
Chlorinated
Aniline
Aniline
Naphtlens Derivates Dioxide, of
Coper,
Naphtlen Hydro- and Xylene, The Tin
409 398 319 317 303
284 268 219 205 188 172 157 145 138 127 104 49 26 21
Ls
a ere,
i
of
times panies from ). with of iorne tohfe with the 447
Toxiclogy acoanate parlel Cancer Lung theseseven The
156
in
paral el
: cancer
often this w cancer chromate picture often the two plants
ther with plants United records lung the limited limited w difference
populations
Whether proces limted side folowi States although plant length were without although the plant
deaths deaths
detrmined reported employingAme color first per
deaths deaths
length from
cause
cent man Ame which adds were The man
The The no compounds was from 1445 compounds are Her
bichromate in chromate nature chromate the depart
bichromate
bichromate
chromate men. now sodium the depart
probably
bichromate
and dust in He probably
deal
It
dust probably
This
caroly of ] revealed revealed a bronchiogenic caroly f compound responsible sugests
t
extracting compounds bronchiogenic re with Recntly
have
published caroly first
As ociation
Lung Lung
determine determine
Anderson Dible betwen ;
study incident chromates relation dust in courseThis
between
presented
evidence as acid 16 the
the
i
#
|
fairly
adequate ocupationl deaths sytem says devlop caners among respiratory respiatory plant wit ocupational 32 were lung with deaths among the
cancer caner ocupationl cancer yield system th adequate
employment
sevnth were
employment lung evidenc deply embde tisue from cels which embeded 10
records
ocupation This intersital dug intersital asbestosasbestos leftmeans doubt dug which These pulmonary
of pulmonarypulmonary chronic chromato chromato The indurating were ocurence occupation Since reported deaths respiatory syste intersital have per dustry dustry
complicated is cancer the expectedratio presnted tendcy ratio cancer cancer Lynch asociated Se asbetosi described squamos metasplasi times the death ning rate
expected cancer
to the
ning than groups tenative predominatly asbetosi the rate grou epithelium their years was higher comparble predominatly squamous age group dustrialyears age
under
cancers age comparble cancer with under The rate cancers
predominatly times The per
asbetosi. lung cancer about slightly lower
The of the irtaing comparble irtaing the Several other
great
importance lung atributes asbetosi the facts incidence
caner whic asbetois of court further complicated and study 2 study of cases
complicated proces regard cases
tenativelyincdencpulmonary chromate suronds asbetosidiscusing chromite, change. posible trivalent sodium among cancer shown of 2308 were
urged. that seventh 46
cancers
were from all cancers and
The
deaths cancer
total
influe
figures
influe
the chromato cent deaths respiratory
1.3 per
times
syste
the
cent The The
the normal
conditon higher comparable
years for
in
groups
years
to
over industrial 0.21 cent than comparble court importance
nasal iritation iritation
was
was
per industrial on
revealed
perforation perforation perforation dos
ports among among asbestos
the takes
origin is high
ocupational cancer
lung lung
develop Islands
in cancer fibrous
asbestos particlesparticles cells lymph
contain
contain
pneumonitis
is hronic
indurating
the
to metastasi
metastasis
metastasi
metastasis
with
less
than
cancer slow slow tendency described described cases
and Smith
as cancer
asbestosis and
bronchial bronchial epithelium conditon
squamous
which which they
above cited
of present precancerous
of cancer
predominantly
primary
squamous squamous
lung
cancer
cancer
cent
only cases it was
cent 0.21
and
of
but
were complicated
in a a were in But with to asbetosi
of
is
the as the study both
may
lungs con- is re- Klotz be
plant in of the in
lay D2 plant to lung same plants 447
but are
>Another Industrial Toxicolgy one-half claimed nations Industrial leagues report proved. English Cancer Lung Industrial Toxicolgy dence That Toxicology some cases some Cancer the 1941 Another of
case lung asbestos worker wasreport poulation. gases asbestos continualy cancer
Linzbach Wedler were contiualy contiualy exposed Cancer ocured uperhot 65 by in 538 was Teleky The exposed years ran flames Linzbach there was times 1934 Wedler Byworker with Anotherradiolgicaly radiologicaly radiologicaly
revaledhad 1940. involed teristic was involved death most 1940 revealed asbestosis teristic and and relative of Laborty seting posiblty frequent often describes complicatedcomplicated che a squamous posiblity Lovelock describes The
and
to
squamous squamous
Laborty employed difcult coal Welsh Saranac mechanicaly of mechanicaly
tar
patient
in death
Autopsy Autopsy
squamous cell
and the one
was
follo
in
possibility squamous
6
continual y
exposed
Lung
448
the Lung
gases
dust
flames
ages
nine years
says as
posure
nine
seventeen
most
metastases
that
in In Lovelock
describes
Welsh
employed
twenty
employed
the
occurred relative
relative complicated
complicated complicated and
years
cancer admits posiblityincreasd Germany miner carcinoma mines inflamtions which changes other among from years inflamations metal miner carcinoma contentcontent similar changes iritaing iritaing ocur ch which inflamations seting patient aparentlyaparently wide
notably tuberculosi 1202 containedwith subtance carinoma carinomadied genralized genralized tuberculosi increasd cancer lungs substance see increased lower primary dence
someEnglishprof conetion conection betwen Iritans poulation can grinders culosilater pulmonary pulmonary subtancethe carinoma aprently respiatory refuted dence grinders Hueper culosis decreasingpulmonary incfalruceinznaoma epidemic disease staistcs the genpuelmronaarly siderosi lungs decreasing ianpflreunetlnyza of statistics cancer Hueper theory 1918 prof that pulmonarygrinders not severeincrease refuted some
He scaterd conection See Kenaway proved scatered and [ proved
changes
lung tuberculosi tuberculosis
primary
Asociation Cancer
of
connection
that
lungs lungs
cases says in rug
occur epithelium epithelium
tuberculosis
their
with
patient
Injected contained
Vorwald
]
Iritants pulmonary
does
that the general
cancer cancer
of
the
pulmonary and
times m
population times
con ection
is
as
in latter
the is been decreasing two strable strable effect effect
genl the lungs
'
@
EnglishEnglish
aparently from
eight
but
(
of
generalized
of
respiratory
ap arently
the
increase
increase
pulmonary
influenza
had
epidemic
( Kenaway
Kennaway
Kennaway
Kenaway Kenaway Kennaway
Kennaway
acount ;
dust of
that
modernthe thanwomen hardly cigarete ocupational modern the
would Englishthere
be injection theory efect. subctaneous his has
afectd pulmonary contiualy injection staistc cities been the use use an subtance aparentemlpyoed involed; bas
describes exposed asphalt cancer asphalt sevre 192]
(Kenawy sevnte increas increas afected obvi Cancer and
infectious carinoma metase influenza that not
aprently normal in run theonly and
vareiotwemny-atwocomplicated flames, exal run of
mortem Kenawy respiratoy epidemic ocured refuted uper lung
pulmonary cance content duri disease caner encountered working
[See
difcult relative working but
duri genralized staistc, of538])
The tuberclosi bronchus. frequncy containg 1.4-fold demon- predis- guinea The cancer tuber: mines. be to show
cigarete cigaretesmoking than
or occupational ocupational ocupational
As ocupational
more
has
and with
died,
brain most from The
ages
been
over iner, (744) and often nine of
on
and
that there eight
spinal to the
the was
the
times cord.
is from the from for a to
the
years. men dust, of
while
of
the lungs
ran the
The
righdt ied silica of years
from Lung
85 and
of
of the and with to
1918 by lower
in
liver,
lobe 65 hot
had
coal lobe (a but
of
theyears, gases
no may
for
the case righttheir
has the piglungs The ian lung ex- 449