Document peEzr46Z8jxY6QmEoerEwNmJj

AR226-2863 Material Tested Copies to; E. I. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine HASKELL LABORATORY REPORT NO. 775-77 Httskell Mo. 11,336 Other Codes Sample Ready for Testing 7/26/77 MaterialSubmi ^|Orga ACUTE ORAL TEST Procedure: The teet material, as received or as an aqueous solution, was administered by intragaetric young adult nttle ChK-CD rats in single doses, one animal per dose level. Survivors were sacrificed l4 Results: Dose ("B/kfi? 22,350 13,700 11,000 7i,-5rUmU 5,fWW\J\ 3,4oo 2,250 f^fC\ Solution W As Received As Received 80 80 80 50 50 t;n '"' Mort;allty** D S S - -- -- S S - 0 o - 1 d. 14 d. 15 d. 15 d. If15 J9 d. l4 d. 14 d. Jil.T. ^ u.. ' . Clinical Signs Lethal Dose: Lethargy and prostration. Sublethal Doses: Lethargy for 1-2 days and chronodacryorrhe 1-3 days after dosing at 7,500 mg/bg and. above; -wet and/or s perinea! area for 1-5 days after dosing at 5,000 ng/kg and a stained mouth from 2-5 days after dosing at 11, COO ing/kg and prostration and wet body for 1-3 days after dosing at 7,500 stained nose for 1-5 days after dosing at 13,700, 7,500, 5,0 3,400 and. 2,250 me/kg; stain around, eyes on the 4th and 5th dosing at 13,700 ng/hg; ataxia on the day of dosing at 11,00 5000 ng/kg; weakness, llna>ness, and convulsions on the day dosing and salivation on the 2nd day after dosing at 11,000 Weight loss from 1-13 days after dosing at 670 nig/kg and abo JHUfjhas Summary; | very low toxicity when administered orally, in single doses, to young adult m Approximal^ LetharTBose (ALD) is 22,350 ing/kg of body weight. S^zed.Ooo.no.c. OOlttp8"^ 2 - * Composition: **D - S - ( ) d. = ( ) d. = Found dead ( ) days after dosing. Sacrificed ( ) days after dosing. JFK-.ace Date Issued: October 7, 'Report No. 775-77 1977 Beportby: L-^p^, '^ . T ^ ) Joseph P '-/ Techni .Approved by: Q.^^kj^S A. Michae Chief, Oral Toxi ^ cont c^?^?""""1'0118'