Document peEE4jgaoOE6g9GgLgVnqnxxD

Corporate Toxicology Study Outline July, 1998 MlX-oi n DT22; T-7121.1 FC-129 Title: FC-129 Preliminary ADME Screen in Rats Timeline: In Life Start Date: 7/13/98 In Life End Date: 7/17/98 Purpose: This study is designed to provide preliminary information on the absorption, distribution, metabolism and excretion (ADME) of FC-129. Significance: The results of this ADME screen will be compared to the test results from similar studies on other compounds. Objective(s): The objective is to rapidly screen FC-129 for its ADME characteristics, in particular the formation of persistent metabolites. Protocol: Charles River Rats /Sprague Dawley/CD/ 415-475 g 6 males Single dose, oral gavage 0 and 5 mg/kg 3 rats per group Individually housed in matabolism cages Commercially available certified Laboratory Rodent Diet #5002 (PMI Feeds, St. Louis, MO) ad libitum Water ad libitum Urine and feces collected days 1,2,3 and 4 post dose Necropsy day 4 post dose Liver and sera collected Analysis for parent compound and suspected metabolites by Kris Hansen, Ph.D., 3M Environmental Technology and Safety Services. Sponsor: 3M Specialty Chemicals Division. Principle Investigator / Location / Cost: Andrew Seacat / 3M Strategic Toxicology Laboratory Report: Mean concentrations of FC-129 and its metabolites in the collected tissues for each group will be analyzed for differences between means and considered significant at the p=0.05 level. 000511