Document peDpLXDXZyLgGoL5E4qn8RnGB

FILE NAME Industrial Hygiene Foundation IHF DATE 1950-1962 DOC IHF057 DOCUMENT DESCRIPTION Industrial Hygiene Digest - References Sections with Abstracts 14 Vol Industrial Hygiene Digest -p 28 ~ March 1950 354 The Method of Demonstration by localization and Optical Crystallogical Identification of the Dust Deposits in Silicotic Tissues J.R. Ruttner and _ F. DeQuervain Ztachr f Unfallmed u Berufskrankh 40 10pp 1947 ~ German This article consists of a brief description of the method of micro- incineration and its applications in the lungs It consists in the in the demonstration of dust particles incineration in an electric oven at a constant temperature of 500 C. of frozen sections fixed to the slide with five per cent gelatin After ashing in this way for 50 minutes all organic matter is removed and the inorganic skeleton of the tissue with its impregnated dust particles can be examined with the polarizing microscope When this has been done the ash can be treated with selective chemical re- agents to remove various components which leaves on the slide only the silica component In this way polarization roentgenographic analysis can be carried out at various stages A practical example is given ~- Condensed from Bull Hyg 355 Tuberculosis as a Complication o2 Silicosis Penna Med J. 53 39-40 Jan. 1950 C.H. Marcy A brief general paper on =? dicotuberculosis presenting the problems , in diagnosis The sputum test 1 recommended for positive diagnosis though sometimes difficult to obtain Malignancy fungus infections pulmonary suppuration bronchiectasis Pectious bronchitis and pulmonary fibrosis | may be mistaken for tuberculosis Treatment and management are the same as ' in simple tuberculosis The death rate from silicotuberculosis is high and the only good preventive measure is the elimination dust 356 Impairment of Pulmonary Function in Anthracosilicosis H.L. Motley . B. Gordon L.P. Lang and P.A. Theodos Arch Ind Hyg & Occ Med 2, . 133-159 Feb. 1950 / DEPOSIT N EXHIBT aa: An accurate evaluation of the degree of impairment of pulmonary function requires measurements of ventilation residual air oxygen uptake from the air breathed oxygen saturation of arterial blood and pulmonary circu- lation The wide individual variations encountered in these determinatideotermninatsions preclude the using of any one single measurement as satisfactory for the appraisal of of the heart cases with a disability in all types of cases Strain on the right side as indicated by electrocardiographic changes is found only in . significant degree 2 emphysema and as the degree of emphysema increases a greater incidence c2 the strain is noted There is no apparent correlation between the roentgenographic stage of silicosis and the degree of impairment of pulmonary function in many cases -- Condensed from Authors Summary and Conclusions / Po 357 Pulmonary Asbestosis Anatomicopathologic Study of a Case A. Franchini and G. Canepa Med d Lavoro zo, 161 July 1949 Italian A man 40 years old had worked in factory for 22 applying insulating material to articles of asbestos about respiratory disorders and he died as the result accident During the necropsy the lungs were found to consecutive years He never complained of a streetcar be the seat of Industrial Hygiene Digest - 29 | March 1950 extensive asbestosis The author's direct attention to the disproportion _ between the gross features described and the awareness of trouble The results prove the importance of prophylactic and therapeutic treatment and economic assistance to asbestos workers generally particularly to those who apply insulating material -- Condensed from Arch Ind Hyg & Occ Med 358 tumoral Pneumoconiosis Pneumoconiosis simulating Tuberculosis in a Bauxite Miner A. Germain P. Brugere and P. Cluzel Bull Acad Nat Med 133 273-276 1949 French The case is reported of a man who had been employed in mining bauxite for 20 years previous to 1938. He then left this work to be taken on at the French Arsenal when an ray of his lungs showed no abnormalities Hine years later the case presented a typical picture of tuberculosis Since the man had no exposure to dust except during the 20 years he was employed in mining bauxite the claim is made that bauxite dust was the cause of his condition Comment is made to the effect that a single case does not constitute proof -- Condensed from Bull Hyg 359 Pneumoconiosis and Tuberculosis in Dockers Dealing with Grains I. Dunner Brit J. Radiol 22 717-722 Dec. 1949 and Seeds One hundred dockers who had inhaled the dusts of grain seeds and chemical material were sent to a tuberculosis dispensary because of chest trouble and were examined Of the 100 22 showed pneumoconiotic lesions ray films on the two 43 were found to be tuberculous and 3 doubtful which of Three were suffering from bronchial carcinoma Editor's note There is no information on the extent of exposure or composition of the dust -- Condensed from Author's Summary 360 360 360 Pneumoconiosis after Exposure to Sulfur Dioxide Fumes and Dust from Coke Fires L. Dunner R. Hardy and D.J.T. Bagnall 1214-1217 Dec. 31 1949 Lancet 257 Pneumoconiotic lesions have been found radiologically among workers in a group of workers whose common history was exposure to sulfur dioxide fumes and dust from coke fires Chemical analysis of a fraction of the dust with a particle size of about two microns has revealed iron and Biliceous matter The authors tentative conclusion is that this pulmonary disease arises from the sulfur dioxide or coke dust or both However it is admitted that the evidence now at hand is not conclusive No dust counts or gas concentrations are given Discussion of the paper appears in Lancet Jan. 14 1950 and Dr. Dunner's reply Feb. 11 1950. DEPOSIT N EXHIBT3-9 361 The Morphology of Bauxite Penumoconiosis J.P. Wyatt and A.C.R. | Riddell Am J. Path 25 447-465 May 1949 A description is given of the pathological characteristics found in - ix fatal cases of this disease together with a short description of the manufacturing process with which the disease is etiologically connected and notes on the history and clinical findings in each case The disease me eee teeter Oey wee ave ew - wep tcc ~ oe 1007 a Findings of Bronchoscopy in E. Concina and O. Orlandi Nov. Dec 1951 Italian Silicosis and Rass med Tuberculosis ind 20 424-426 The importance of the existence of bronchial lesions in silicosis _ has been underestimated Bronchoscopy allows direct observations of changes in the tracheal and bronchial mucous membrane deviations in the trachea and main bronchi and modifications in the orifices of the lobes and segments Lavage aspiration of the bronchial section and endobronchial administration of adrenaline and antibiotics may be conducted during the process Inflammation of the mucous membranes and other changes characteristic of silicosis are disclosed by this method Findings _ in 25 patients are reported -- Cond from Bull Hyg 1008 The Value of the Electrocardiograph F. Lavenne Institut d'Hygiene des Communication No. 90 5pp 1951 for Examining Silicotics Mines Hasselt Belgium French _ The author used the electrocardiograph to examine 11 cases of anthraco with clinical signs of loss of compensation of the right ventricle and 200 cases of anthraco compensated for invalidity but still ambulant who were doubly classified according to the extent of fibrosis present and according to the amount of emphysema The findings are presented in somewhat cryptic symbolism They are held to justify the claim that the electrocardiograph may be of considerable value in establishing early strain on the right side of the heart -- Bull Hyg > DEPOSITION J DEPOSITION EXHIBIT J EXHIBIT DEPOSITION EXHIBIT DEPOSITION 1009 Asbestosis Associated with Bronchiogenic Carcinoma and A. A. Angrist Arch Intern Med 88 831-834 R. Stoll R. Bass Dec. German Data for statistical proof of any association of asbestosis with pulmonary carcinoma are hard to collect but three investigators have found carcinoma in 7.5 to 14.8 of cases of asbestosis A case is reported in which a worker had been exposed to asbestos for 6 years and had refused to wear a respirator He came under notice with weakness and a persistent cough Clumps of malignant cells were seen in the bone marrow and ray , showed generalized large discrete oval shadows indicative of pulmonary metastases After death modules varying to 4 cm in diameter were found scattered throughout both lungs with interstitial fibrosis Large areas of necrosis existed throughout the lungs and typical asbestos bodies were seer inside and outside the tumor areas Metastases were found in the kidneys brain and liver The opinion is suggested that the silicate in asbestos must _ itself be directly carcinogenic It establishes an additional reason for pre- ventive measures in the use of asbestos -- Cond from Bull Hyg Set: - Industrial Hygiene | eee . : a INDUSTRIAL HEALTH NEWS BG po | IJTERATURE ABSTRACTS | MEDICAL ENGINEERING CHEMICAL : TOXICOLOGICAL LEGAL ... ... decisions and trends yt vO . mo . ae? ee , a at . . NS JUNE 1957 21 No. a u Vol aJ . sos er 6r _ . in . : : a t J. N. DEPOSITION INDUSTRIAL HYGIENE FOUNDATION Bayone 6 EXHIBIT MELLON INSTITUTE ~ 4400 FIFTH AVENUE 1. PITTSBURGH 13 PA . . a ry atts . oe . . Pe Tene it seeined that particle with sharp angles such as a the light microscope Incidentally could easily pierce the layer It was limited on both the space side and quartz particle cell membrane a basal meinbrane was not the connective tissue side by an staining consisted of seven layers In places found between the blood and the air space The partition to the alveolar wall the cellular tissue were not in immediate apposition where the capillaries lattice threads elastic fibers and connective was filled with connective space tissue fibrils from the alveolar walls and septal cells were found tissue cells Various cells detached be reached on their origin -- Cond from Bull Hyg but a definite decision could not 757 Silicosis M. Anme 11 Effect of Sex Nagasaki Igakkai Hormones on the Amount of Silicon Zassi 31 381-385 1956 Exereted into Urine excretion of silicon before and after castration was investigated In the of females it de- Urirnaabrbyits silicon increased after castration while in the case case of male normal level after the administration of male hormone or Silicon returned to the Chen Absts creased luteum hormone showed no effect -- follicular hormone Corpus 758 1956 on the Amount of Silicon Excreted in the Silicosis 12. Influence of Thyroid Hormone 438-445 of Rabbits R. Kakita Nagasaki Igakkai Zassi 31 Urine increased the urinary excretion of silicon by 2 to 3 times and Thyroidectomy administration of thyroid hormone Injection of silicon returned to normal level after the silicon slightly Diiodolyrosine and anterior methylthiouracil to normal rabbits increased -- Chem Absts hypophyseal hormone showed no effect 759 The Neutralization of Silica Toxicity in Vitro 14 1957 Brit J. Ind Med 81-84 Apr. J. Marks cells were protected in vitro against the toxic effect of silica dust by Phagocytic phenylethyl a histamine agent formed from ~ compound 48/80 direct microscopy and by measurement of their vr mine The health of the cells was studied by of action of compound 48/80 is consumption and dehydrogenase activity The mode action was et glucose a reduction in silica solubility A slight protective but may depend on -- Author's summary ii not known and polymyxin B. k alkylmono also exhibited by certain ' Reaction with Altered Elastic Tissue Endogenous and Giant " 760 Fibrosis Pulmonary Arch Pathol 63 75-90 Jan. 1957 Pneumoconiosis R. L. Walford and L. Kaplan i} \ clinicopathologic findings in 12 autopsied cases of a peculiar pulmonaryelastic . The discussed is concluded that injured pulmonary elastica disease are presented and and produce a progressive pneumoconiosis 1 | tissue may act as a foreign body or sequestrum sequestrum -- Cond from authors summary 761 H DEPOSITNEXHIBT 11 _ Asbestosis with Pleural Calcification among Insulation P. F. Moller Danish Med Bull 3 202-204 202-204 Nov. Workers 1956 J. Frost J. Georg and insulation products including asbestos In Denmark only a few perasnodnsromckanwipouollateThe first two have been regarded as kieselguhr magnesia glass wool their dust inhaled In order to ascertain any occupational fibrogenic to the lungs when of 52 years average age risk in the work 31 workers with more than 20 yeaArbsnoerxmpaolsiutirees were found in the surpris- asbestosis were carefully examined clinically and by ray indicative of pulmonary number of 22 A total of nine exhibited fine mottling and extensive thicken- ing which were due to adhesions In 19 patients pleural changes were seen so widespread in sorne instances abnormalities in the pleura were be ascribed and ing with calcification The The calcification is unusual may to obliterate other pathological changes as of fibrogenic asbestos dust presence to calcium and magnesium in the presence The to combined exposure did not reveal the presence of quartz Sample analyses of the kieselguhr kieselguhr in use series definitely points to an pronounced finding of bilateral pleural changes in the present -- Cond from Bull Hyg occupational origin Industrial Hygiene Digest Vol Vol 25 March 1961 ^ 270 Asbestosis and Abdominal Neoplasms E. E. Keal Lancet 2 1211 1960 as In 1953 an impression was formed at the London pulmonary asbestosis had ovarian Hospital that women suffering from neoplasms more often than other women this suspicion and because of the occurrence of other the On the basis of were investigated During that period 23 cases hospital records since 1948 of asbestosis women and 19 men were admitted with a In this series there were 30 deaths diagnosis with lung cancer 10 men and 4 15 men and 15 women Of these 14 died but this does women This high incidence in men is partly due to selection not apply to the women who were all smokers Death occurred in with peritoneal cancer and in 9 women with ovarian one man more than a chance or peritoneal cancer This appeared to be association and spread from undiagnosed lung cancer seemed At least 4 of the tumors were not of ovarian origin unlikely Some evidence of hematogenous spread af asbestos fibers was adduced and it was suggested that a combination of mechanical and chemical factors may determine the peritoneum as the site of neoplastic change No inflammatory and subsequent single satisfactory explanation for these the available material cases could be drawn from though they appeared to form a clinical entity of statistical significance -- Can Med Assn J. Absts Investigation 271 Occupational Medical Schweiz med Wochschr 90 in Cement Works Jenny M. Battig et al 705-709 June 25 1960 German is This the first systematic investigation in Switzerland into the possibility of res- piratory complaints arising from the inhalation of cement dust Swiss No free silica is present in cement so silicosis is not a risk a fact confirmed by the radiological examination of some of the workers In all 488 employees at 3 factories were studied The absentee rate at one of the factories was much higher than at others the of cough and of those with percentage men complaining of due to social factors sputum was also higher in this plant The cause of this might be partly epidemics etc. A study of smoking habits shows that exposure dust does not increase coughing in smokers It is to cement suggested that those who are resistant to moker's mokerc' ous gh are also resistant to dust smokers show a with chronic cough as compared with figures given by another authsuorrpriPseirnhgalypshiaghbeptrtoeprorctoimo- n parison would have been with a occupational group studied by the authors themselves However it is concluded that this shows that cement dust is ages Physical signs found did not lead irritating to the respiratory pas- to any definite conclusion Vital capacity was not in- fluenced by the length of dust exposure In few workers the maximum reduced An attempt was made to relate the expiratory force was the workers into 3 findings to the intensity of exposure by dividing groups The 2 groups most exposed to dust showed a pathological signs but the difference tendency to increased . was not statistically significant - -- Bull Hyg 272 & Study of the Physiological Effects of Carbon Black 3 Adsorption Subcutaneous Injections C. A. Nau J. Neal and V. A. Stembridge Arch Environmental Health 1 512-533 Dec. 1960 and Elution Potentials Neither blood plasma nor gastric juice elutes any significant adsorbed when a channel black is suspended in either medium for as long as 7 days component Neither blood plasma nor gastric juice elutes any significant adsorbed component when a furnace black is suspended in either medium for as long as 7 days Channel black binds artificially so firmly that it cannot be removed in benzpyrene adsorbed toto by benzene extraction No signifi- cant extraction of either channel or furnace carbon black was to which 10 cooking oil was added when accomplished with gastric juice contact was maintained for 7 days Subcutaneous or traperitoneal injection in mice of channel or furnace carbon black leads to no significant changes from the normal Benzene extractives of furnace blacks when injected in oil into mice lead to tumor formation Carbon blacks channel or furnace can absorb and bind known carcinogens so effectively that no tumors are produced when the adsorbed material is subcutaneously injected Tricaprylin when injected subcutaneously in mice may cause tumor formation DEPOSITION DEPOSITION ~~ Authors conclusions DOntian im EXHIBIT 19 Industrial Hygiene Digest 26 oo vat August 1962 757 Diffuse Pleural Mesotheliomas in South Africa S. African Med J. 35 28-34 1961 C. A. Sleggs P. Marchud and C. Wagner ani ^fin industry Although diffuse pleural mesothelioma is regarded as a rare tumor the authors have had personal experience with 3+ cases This remarkable experience is apparently related the area of asbestos production in South Africa Asbestosis was seen in 6 of the 7 autopsies 9 of 11 biopsies However only 19 of the persons had been employed in the asbestos all but two of the remaining members of the group had been born and lived in this to ducing area of Cape Province Symptoms began with bronchitis and pleural pain aprsobgersestsoesd ; pa- pleural effusion and pleural thickening and finally manifested thoracic malignancy Eight tients developed peritoneal involvement Other metastases had involved cervical nodes sub- : cutaneous tissue and the tongue Experience with therapy had been very unsatisfactory the patients of the group who died % did so within the first year 4 years was the longest survival time observed -- APCA Absts 758 Foreign Body Granulomas Caused by Glove Dusting Powders K. Hupe Chirurg 33 97 Mar. 1962 Chirurg Der Zeitschrift fuer alle Gebiete der Operativen Medizin Springer Heidelberger Platz 3 Berlin Wilmersdorf West German*y give corn After it had been discovered rise to postoperative formation of starch powder be used in place of that the use of talcum powder in surgical gloves could granulomas and adhesions it had been recommendte hadt talcum The author investigated the reaction to corn starch powder in 24 rats Corn starch glove powder was injected subcutaneously into the fat tissue in doses of 50 or 100 mg and intraperitoneally in doses of 200 mg The animals were : killed in groups of 4 at intervals of one month Except in 2 animals in which the subcutaneous fat tissue contained a nodule the size of a millet seed 1 and 2 months after the injection of 120 mg of powder no granuloma formations were detectable macroscopically None of the animals showed intraperitoneal adhesions Histological studies on the subcutaneous fat tissues revealed ; in all animals at the sites of injection typical foreign body granulomas with macrophages kis- tocytes lymphocytes giant cells fibroblasts and capillary buds Starch granules were dif fusely disseminated and after one month about half of the granules had been incorporated ints cells and after 3 months all were intracellular At this time lymphocytes and giant cells showed considerable retrogression After 6 months many starch granules had been phagocytized by histiocytes and macrophages The author concludes that although starch powders are less in- jurious to tissues than are talcum powders in that they cause less inflammation and granulasa quantitative formation the difference is only cles are not completely absorbed They are not indifferent since inoculated panirut The formation of new collagenous or elastic fibers was , observed No intraperitoneal adhesions developed from corn starch powders -- J. Am Med Assn References and Reviews PHYSICAL ASPECTS OF THE ENVIRONMENT 759 Myocardial Damage in Caisson Workers Arch Gewerbepathol Gewerbehyg 18 I. Rozsahegyi and I. Kenedi 610-631 1961 German DEPOSITONEXHIBT5-5-99 TW The present paper from the State Institute of Industrial Medicine Budapest contains an account of the study of 316 caisson workers engaged in building the Budapest undergoaund railway and a control group of 300 men in other types of work The purpose of the study was to determine the comparative incidence in the 2 groups of electrocardiographic signs of myocardial damage the actual types of these signs and the relation of these signs to ability to work at increased atmospheric pressure Among the conclusions the following are stated 1 Abnormalities in the electrocardiogram were significantly more frequent in caisson workers at all ages than in control workers This finding is all the more important because the precautions takes * Address not in current List of Periodicals 20 Industrial Hygiene Digest 26 December 1962 e Se se symptoms were referable to the central nervous system and that he died from terminal pneumonia following a rapidly progressive encephalopathy associated with epilepti- e form attacks He had no presenting pulmonary symptoms and ray examination of the ee chest showed only slight abnormalities.- Radiographic examination of the chests of 53 other workers in the same factory and clinical examination with lung function tests of 23 of them oe revealed no other definite cases of aluminum fibrosis of the lung nor any other cases with neurological signs and symptoms Estimations of the aluminum contents of the body tissues such as the lungs brain liver and bone are also recorded When compared with normal . values it was found that the lungs and brain contained about 20 times and the liver 122 times more than normal The results of a survey of the dust concentrations in the factory are also given The use of aluminum compounds in the experimental production of epilepsy in primates is reviewed it is suggested that the neurological signs and symptoms with epileptiform convulsions which occurred in this case might have been related to aluminum in- toxication The authors.hold authors.hold the view however that the interstitial and nodular fibrosis found in the lungs dust was undoubtedly associated with the inhalation and retention of aluminum +--+ Cond from authors abst 1171 Pleural Asbestosis H. B. Eisenstadt Am Practitioner Dig Treat 13 573 Sept. 1962 American Practitioner and Digest of Treatment 227-231 South Sixth St. Philadelphia Pa * Because of the widespread industrial use of asbestos the number of persons suffering from asbestosis is increasing Frequently the correct diagnosis is never established Pleural asbestosis may occur with only minimum parenchymal involvement and it may present itself as acute chronic or recurrent pleuritis or as pleural mesothelioma Three cases were ob- served among oil refinery workers one with recurrent pleurisy one with pleural calcification followed by tumor formation and one with primary mesothelioma Only lung biopsy will es- tablish the correct diagnosis Pleural biopsy is nonspecific -- J. Am Med Assn References & Reviews 1172 Asbestosis and Carcinoma of the Lung Cancer 15 1181 Nov. 1962 J. F. Cordova H. Tesluk and K. P. Knudtson Eleven cases of asbestosis associated with carcinoma of the lung are presented A known exposure to asbestos dust was obtained in 7 of these cases In 2 cases evidence is presented for multifocal origin of the malignant tumor The relationship of asbestos bodies as a carcinogen in the production of lung cancer is discussed -- J. Am Med Assn References & Reviews PHYSICAL ASPECTS OF THE ENVIRONMENT DEPOSITION EXHIBIT 1173 Restoration of Hearing by Surgical Procedures _ J. Occ Med 4 518-520 Oct. 1962 F. A. Perri The author has determined that the stapes procedures which are more extensive than mobilization procedures are far more likely to produce a permanent return of auditory acuity to levels within acceptable social limits In a few instances the operation described has been performed on patients having a loss of hearing by bone conduction at or near the 30 db level with improvement shown audiometrically by air conduction and bone conduction -- Author's conclusion * Address not in current List of Periodicals 21