Document pX3vwyEvQ9wDGGQRyyxv3DR7

life W te uB'-St j ii ' !bi r y ^ -- ---- flW --- -- <- . *... -- . -- _ Vr?; . . -u^.. ii'V-m.13. __M__f_i_r_i_t__lb__p_g_M_ __u_c_tm_ ___ ___ Discussion - a s 9-- ilfoalthcifocta ok Electrical rad $CAil .D *^^ ^ i S U ^ v i a r s found with PCS .! Man isomers ofPCB "art found in any nixturn Of PCBa, ...l':;-T*omaOf which are gxtrembly toxic?- '*r. . nir^-rir-S.' 2TSr-'tliL'* 39:, '-'p *i.V^ U$P.. &? 4*\. ort*. n rrx-w *c- v ' S i * . ? * 'Citd of PCB i&dtttti' besidt'bidaccumuiatiori la not /.clear. ; Tor example, photooxldatldrt Of PC$ :td PCbr does occur (RUtslnger IST4)v but the probability Of'such occurrence In naturu la not known* D. Resting of PCBa as would?abeur with PCB uit in haat exchangers roaulta in inertaaod conversion to PCDF. it ia not d e a r how tflUy addraaa this Issue and ita Inherent riak. Bow hot do capacitors and "closed" systems pat in thair lift tin, what convertion occurs? *r o -";"-*-1-?:*-* *- -** R. ` Given the limits of our*attsmpts.taPelimlnate the remaining PCBa in the environment, its transport through tha food chain uncertain chemical transformations, `id worrisome persistence-In the animal world as tha type of chlorination' changes and the degree increases, it ppeafs extremely unwise to change ;any position without much further work at the health and basic'chemical (levelin '3<*' -r; j:.-j .&m * II Peflclenclaa in conelderatlon of reproductive affecta I A Incraaaad estrogen affect may be seen via two different mechanii 1 Estrogen like activity which would add to or compete with ^endogenous ^trogens (utarotrophic activity in rats, Gallatt 2 Increased metabolism of endogenous eatrogans through PCS offset on hepatic-HPO system These types of effects could easily aooount for menstrual Irregularities assn as wall as lapair thSvdklllty to maintain the fetus. .vs., a .. . . '^ A^j:i r V ' k ^ d l 7'Studies Winger 1ST2, tinder 1974, Vllleneune 1971 " u n ' pronounced fertility problems depending upon PCB type 53/^ni animal specie*.st less than 50. *v * ** i--V.* 036^9^ C. Effects on humans t 1 Yusho cooking oil incident shoving low birth weight/ 1developmental delays is of concern* Reproductive effects are seen in rhesus monkeys at 2* 5-5-0 ppm by pirified PCBs and in the mink* a sensitive animal species. Thus although PCDF is admittedly dangerous PCB is not "obviously" safe. 2* Reproductive effects are being investigated in a group of women who work with capacitor grade PCBs In an Edison facility. Increased rate of low birth weight Infants is one outcome under investigation by NIOSR* This type of study as well as one addressing incidence of infants with developmental delays are needed* .D. General health vs PCB 1* Given the problems of small numbers and our presently inadequate ability to address reproductive health questions of menstrual irregularities* decreased fertility* developmental delays and minimal brain dysfunction* animal studies must be given perhaps additional weight* 2 Each PCB mixture contains as many as 70 different compounds and has unique characteristics which represent a separate risk independent of its later chemical fate* Chemical transformations during use and after disposal represent yet another risk needing evaluation recognizing the uniqueness of each environmental situation* t 11 NEV 036495