Document pRaaJ8KZ4XyEJGLMXqk3MONw

r > r' \2-44 Rivi/ mm ISUtnsmoiBc; E. du Pont de N em ours & C o m pan y IN COR PORATE O W il m in g t o n , D e l a w a r e 19898 POLYMER PRODUCTS DEPARTMENT EXPERIMENTAL STATION PERSONAL AND CONFIDENTIAL A. J. Dahl B. V. Karrh L. J. Papa Pral File I.C. - 353 - r;n - 219 October 20, 19&1 1 C: FR01 DR. Y. L. POWER - PPD, Parkersburg S. S. STAFFORD ANALYSIS OF BLOOD SAMPLES FOR FERFLUOROOCTAKOATE (Job No. 810-578; FRAL Nos. 81-^363-^*386; ________Notebook Eos. T:22>lk ,E26238 ,E27**32 ) As requested in your letter of 9/22/81 to L. J. Papa, the i blood ss.rr.rle; submitted then have heen analyzed for perfluorooctanoate (Cg) by the usual gas chromatographic method E5-567- Results and sample identification are giver, ir r'r.e attached table. Attachment jah Key Words: Perfluorooct anoat e GC Blood Analysis + r ? wr-.rir! '* w/f*n rWu'H* ;U 0001S4 EXP000061 EID713875 TABLE I CONCENTRATION OF PERFLUOROOCTANOATE IN BLOOD (a) Samole PRAL No. Date Sampled 81-1+363 81-1+361+ 61-1+365 8I-U366' 61-1+367 81-1-368 9/8/81 9/8/81 9/8/81 9/9/81 9/9/81 9/9/81 81-1+369 9/9/81 81-1+370 81-1+371 81-1+372 9/10/81 9 /1 0 / 6 1 9/10/81 81-1+373 9/11/81 61-1+371* 81-1*375 81-1*376 81-1+377 81-1378 81-1*379 61-1+380 81-1+381 81-1+382 9/11/81 9/1 U/61 9/1 I+/61 9/I5/&1 9/15/81 9/16/81 9 /16 /8 1 5 /1 6 / 6 1 9/17/61 81-1+383 81-1+381+ 8I-I+3S 5 81-I+386 9/17/61 9/18/81 9/20/81 9/20/31 P.R.No. Name GC Analysis___________________ (t Date Analyzed [Cr }, Dg F/g blot 1 0 /5/81 10/2/81 ` 10 /2/81 10 /2/81 1 G/5 /B1 10 /2/81 10/5/81 1 0 /8/81 10/5 & 10 /6/Sl 10/5/81 1 0 /5/81 10/5/81 10/5 h 10 /6/81 10 /S/Ei 10/9/81 1 0 /8/81 1 0 /8/81 10 /8/81 iC/8/81 10 /8/81 10 /11/8 1 10 /8/81 10 /6/81 10 /6/61 2.6 0.G3+1 C .2C C .il 2.0 C.ll C .3c 0.15 1.5 0.21 0.090 0.26 0.33 0.33 2.6 0.071 T />, " - r , f. C .2C c .5 0.022 l.C 0.2-3 (a) Analysis as described in Lab Method ES-567 ("Determination of Perfluorccctancie Acid in Blood, Gas Chromatographic Method" , S. Stafford, 2+/3/S1), using the packed column GC analysis vith perfluorc-n-octanoic acid as calibration standard. (t) Although the analysis is specifically for perfluorooctanoate (acid cr salts), concentrations are given in ppm fluorine for comparison vith the results of total organic fluorine analyses. (ppm F = 0.688 x ppm perfluorocetanoic acid.) Estimated uncertainty is _+ 10? relative standard deviation. The lover limit for quantitation is 0.007 PgF/g. The detection limit is a- O.OOl Pf.F/r, tut concentrations in that range cannot be veil quantitated and are reported as < C.007. None detected (n.d.) is reported for samples vith [Cg ] ` 0.001 ppm, vhich cannot be distinguished from reagent background. ,, *REDACTED* U 0 0 155 EXP000062 EID713876 i -a% nrv o tSTAU'.KC.IBt . E. d u P o n t d e N e m o u r s S C o m p a n y INCOAPOnk TeD W il m in g t o n , D e l a w a r e 19898 POLYMER PRODUCTS DEPARTMENT EX PER IM EN TAL 57 AT|ON PERSONAL AKD COKFIDSHTIAL cc : A. J. Dahl B. V. Karrh L. J . Papa Pral File I.C. - 352 - Blit 0C - Zu 9 A/Z2U>'/5 October 27, 1981 TC: DR. Y. L. POWER - PPD, Parkersburg FROM: 5. S. STAFFORD <T ANALYSIS OF BLOOD SAMPLES FOR PERFLUOROOCTANOATE (Job No. 810-578; PRAL Nos. 81-L598A627; _________ Notebook Kos, E2251^,E26238,E27i<B2) As requested in your letter of 10/6/81 to L, J. Pape, the 30 bleed samples submitted then have been analyzed for perfluorooctanoate (Cg) by the usual gas chromatographic method ES-567. Results and sample identification are given in the attached table. Attachment jah Key Words: Perfluorooctanoate GC Blood Analysis There e s worlc o: Kuna' we 'C dome Eomelhmg abend 000156 EXP000063 EID713877 TABLE I CONCENTRATION OF PERFLUOROOCTANOATE IN BLOOD (a) Sample PRAL No. Date_ Sampled 8I-U598 81-1+599 8I-I46OO 1-1601 81-U602 81-14603 8l-U60iH 81-U605 81-U606 81-U607 81-U60& 81-1+609 81- 11610 82-1+611 61-U612 81-1*613 8 1 -1+6 1 *+ 8l-*+6l5 81-U616 61-U617 8l-l46l8 81-1*619 8 1 - 1*620 81- 1*621 81-1622 81-1*623 8 1 -1*621+ 81-1*625 81- 1*626 81-1*627 9/ 22/81 9/23/81 9/23/&1 9/2-/61 9/2L/81 9/ 26/81 9/25/81 9/25/81 9/25/81 9/ 28/81 9/28/61 9/28/81 9/ 28/61 9/29/81 9/29/81 9/30/61 9/30/61 9/30/cl 9/30/81 10/1/81 10/1/81 10/1/81 10/ 1/81 10/1/61 10/i/ei 10/ 2/81 10/5/81 10/5/81 10/5/61 1 0 /5 /6: P.R.No. Name It1+90 W.S. 1*293 3872 181*3 W.S. 1572 W.S. W.S. 1*380 1*621 1*097 W.S. 3708 W.S. W.S. 1632 1762 1*533 1778 W.S. 872 31*7!* 1* 1*95 3U90 1*057 1727 V. W. 1972 S. S. GC Analysis _____________(b) Date Analyzed [Cal, PE P/k blood 10/9/81 10/9/62 10/9/81 10/9/81 10/9/61 10/11/81 10/ 11/81 10/11/81 10/11/81 10/12/61 10/12/81 lC/12/81 10/12/81 10/12/61 10/12/61 10/12/61 10/23/61 10/12/Sl 10/ 13/81 10/11* & 10/23/81 10/13/81 lC/13/81 1C/13/S1 10/13/81 10/lt/6l lC/13/81 lC/13/8: 10/13/61 10/13/61 10/13/81 0.10 0.21 Q.lk C . 26 0.16 C.i*5 7.5 0.95 0.C70 0.66 0.12 0.17 O.089 0.25 0.12 0.96 6.5 O.I-3 C .22 C.0093 0.35 0.62 C.17 0.059 8.2 0.27 C .26 0.2C 0.050 2c 000157 REDACTED* EXP000064 E I D7 13878 TABLE I (COm'J)) Analysis as described in Lab Method ES-567 ("Determination of Perfluorooctancic Acid in Blood, Gas Chromatographic Method", S. Stafford, 1/3/81), using the. cached column GC analysis vith perfluoro-n-octanoic acid as calibration standard. Although the analysis is specifically for perfluorooctancate (acid or salts), concentrations are given in ppm fluorine for comparison vith the results of total organic fluorine analyses. {ppm F = 0.665 x ppir. perfluorooctanoic acid) Estimated uncertainty is _+ 10f relative standard deviation. The lover limit for quantitation is D.0C7 ugF/g. The detection limit is a, 0.00*+ PgE/g* tut concentrations in that range cannot be veil quantitated and are reported as < C.C07. None detected (n.a.) is reported for samples vith [CgD ^ O.COl ppm, vr.ich cannot be distinguished from, reagent background. 000158 EXP000065 EID713879