Document pBk6yd3wjQR4kBoQVLmxmRv7X

MINUTES OF MEETING CMA EXECUTIVE COMMITTEE Briargrove Room, Galleria Plaza Houston, Texas Monday, October 27, 1 980 1. The meeting was called to order at 2:00 p. m. by the Chairman, There were present; Paul F. Oreffice, Chairman Harry W. Buchanan Louis Fernandez Alexander F. Giacco James B. Henderson Richard J. Hughes H. Barclay Morley L. John Polite, Jr. Robert A. Roland William G, Simeral Raymond C. Tower Konrad M. Weis Bruce M. Barackman, Secretary Edmund B. Frost, General Counsel Gary C. Herrman, Treasurer By Invitation: Geraldine V. Cox, CMA Fred Dehn, PPG Industries, Inc. Richard F. Gold, Stauffer Chemical Company W. C. Krumrei, The Procter & Gamble Company Roland L. Lang, SOCMA Keith R. McKennon, The Dow Chemical Company T. W. Mooney, The Procter & Gamble Company Victor H. Peterson, CMA Edward B. Poliak (SOCMA), Olin Corporation George F, Polzer, Witco Chemical Corporation H. C. Shah, CMA James N. Sites, CMA Curtis W. Smith, Shell Chemical Company, A Division of Shell Oil Company William M. Stover, CMA part time 2. Minutes of the September 8, 1980 Meeting The minutes of the September 8, 1980 meeting of the Executive Committee, as distributed, were approved. 3. Treasurer's Report Mr. Herrman's report is attached as Exhibit A. He noted the following significant items: CMA 012733 A partial "list of 65 chemicals designated as priority pollu tants is shown in Table 4. E. Occupational Safety and Health Act (OSH Act) OSHA has recently published a list of substances which are candidates for further scientific review and possible iden tification, classification, and regulation as potential oc cupational carcinogens. Chemicals on this list are shown in Table 5. This list does not include chemicals on EPA's Cancer Assessment Group listing. Chemicals identified by CAG as having substantial evidence of carcinogenicity are listed in Table 6. Since 1970, OSHA has initiated rulemaking proceedings on asbestos, vinyl chloride, coke oven emissions, arsenic, benzene, acrylonitrile, and beryllium in addition to the ori ginal 14 carcinogens. The CMA Executive Committee in 1977 approved an advocacy program for benzene in response to an unjustified workerexposure standard proposed by OSHA. The CMA Benzene Program Panel successfully supported the American Petroleum Institute in rebutting that standard. As OSHA initiates additional rulemaking procedures on specific chemicals, the need for services from CMA's Special Programs Division may also in crease. F. National Toxicology Program (NTP) - A Non-Regulatory Activity withinthe Department of Health and Human Resources Having Significant Impact on The Chemical Industry The Government agencies participating in the NTP program are: FDA, NCI, NIEHS, and NIOSH. The major task of NTP is to identify those chemicals that must be controlled to prevent disease. The program, proposed in the 1980 Annual Plan of NTP, called for testing about 600 chemicals with an operating budget of $68.8 million. An alphabetical index of chemicals cited in the annual plan is shown in Table 7. It is in the interest of companies producing and processing these chemicals to form special programs under CMA to continuously follow the research conducted by NTP and to generate their own data if they do not agree to the conduct of research being performed by the Govern ment. Even though EPA and OSHA are not currently participating in NTP, data generated from this program will be used by both of these agencies to regulate the production and processing of chemicals designated "toxic" by NTP. CMA 012734 Table 4._-- A Partial List of 65 Chemicals Designated as I- Priority Pollutants Arsenic Benzene Beryllium Cadmium Carbon tetrachloride Chlordane Chlorinated naphthalenes Chloroform 2-chlorophenol Dichlorobenzenes 2,4-Dimethylphenol 2,3,7,8-Tetrachlorodibenzo-p-dioxin Fluoranthene Heptachlor Hexachlorobutadiene Hexachlorocyclopentadiene Lead Nitrosamines Pentachlorophenol Selenium Silver Tetrachloroethylene Thallium Trichloroethylene vinyl Chloride - 17 CMA. 012735 Table 6. -- Chemicals Having Substantial Evi dence of Carcinogenicity; CAG List 2-Acetylaminofluorene 1 Acrylonitrile (CAG.'IARC) Aflatoxins (IARC) * -- Aldrtn iCAG. NCI) 4-Aminobiphenyl (IARC) Amitrole iIARC) --- Aramite <IARC) Arsenic and Arsenic Compounds (CAG, IARC) Asbestos (CAG. IARC) Auramine and the manufacture of Auramine (IARC) Azasenne (IARC) ' Benzie'acridine (IARC) ` Benztaianthracene (IARC), Benzene (CAG. IARC) Benzidine iCAG, IARC) Benzol a)pyrene (LARC) Benzoibifluoranthene (IARC) Benzoij)fluoranthene (IARC) 1 Beryllium and Beryllium Compounds (CAG, IARC) N.N-Bis( 2-Chloroethyl)-2-Naphthylamine (Chlomaphazme) (IARC)' Cadmium and Cadmium Compounds (CAG, IARC) Carbon Tetrachlonde (CAG, IARC) Chlorambucil (IARC) ' Chloroalkyl Ethers Bis( 2-chloroethy1 (ether (BCEE) (CAG) (IARC) ' Bis(chloromethyi)ether (BCME) (CAG. IARC) Chloromethyl methyl ether (CMME), technical grade (IARC) Chlordane (CAG, NCI) Chlonnated Ethanes 1.2-Dichloroethane [Ethylene Chloride, Ethylene Dichloride (EDC)J (CAG, IARC, NCI) Hexachloroethane (CAG) 1.1.2.2-Tetrachloroethant (CAG) 1.1.2- Trichloroethane (CAG, NCI, IARC) ` Chlorobenzilate (CAG) Chloroform (CAG, IARC) Chromium Compounds. Hexavalent (CAG, IARC) Chrysene (IARC) 1 Citrus Red No 2 'Tarci Coal Tar and Soot (CAG included in lARC's soots, tars, and oils designation) Coke oven Emissions I Polycyclic Organic Matter (POM)) (CAG) Creosote (CAG) Cycasm (IARC) Cyclophosphamide (IARC) * Daunomycm (IARC) ' DDT (Dichlorodiphenyltrichloroetbane) (CAG) Diallate (CAG) (IARC) 1 Dibenzia.hiacridine (IARC) Dibenii a.j (acridine (IARC) Dibenz(a.hianthracene (IARC) 7H-Dibenzoic.g)carba2ole (IARC) 7H-Dibenzo<c.g)carbazole (IARC) Dibenzo(a,e)pyrene (IARC) Dibenzo(a.hipyrene (IARC) Dibenzo(a,i)pyrene (IARC) 1.2- Dibromo-J-chioropropane (DBCP) (CAG, IARC, NCI) 1.2- Dibromoethane (Ethvtene Bromide, Ethylene Dibromide (EDB)| (NO. CAG, IARC) 3,3'-Dichlorobmdine (DCB) (CAG, IARC) Dieldrin (CAG) Diepoxybutane (IARC) 1.2- Diethylhydrazine (IARC) Diethylstilbestrol (DES) (IARC) * Dihydrosafrole (IARC) 3,3'-Dimethoxybenzidine (o-Dianisidine) (IARC) p-Dimethylaminoazobenzene (IARC) 7.12-Dimethylbenz(a)anthracene 1 3,3'-Dimethylbenzidine (o-Tolidine) (IARC) Dimethylcarbamoyl Chloride (IARC) 1.1-Dimethvlhydrazine (IARC) 1.2-Dimethylhydrazine (IARC) Dimethyl Sulfate.(IARC) 2.4-DmitrotoIuene (CAG NCI) 1.4-Dioxane (NCI) 1.2-Diphenvlhydrazine (CAG) Epichlorohvdrin (CAGi Ethylenebisdithiocarbamate (EBDC) (CAG) Ethyleneimine (Azindine) (IARC)1 Ethylene Oxide (CAG, IARC) Ethylenethiourea (CAG. IARC) Ethyl Methanesulfonate (IARC) Formaldehyde (CAG) Glycidaldehyde (IARC) Hepuchior (CAG, NCI) Hexachlorobenzene (CAG, IARC) Hexachlorobutadiene (CAG) HexachJorocyclohexane (HCH) HCH (CAG) HCH (Lindane) (CAG) Technical HCH (CAG) Hydrazine (IARC) lndeno( 1,2,3-cdlpyrene 'IARC) Iron Dextran (IARC) 41 Isosafroie (IARC) Kepone (Chlordecone) (CAG, NCI) Lasiocarpine (IARC, NCI) Melphalan (IARC) ` Methapyrilene (FDA) ` 3-Methylcholanthrene 1 f 4'-Methylenebis(2-Chioroaniline) (MOCA) (IARC) Methyl Iodide (CAG, IARC) Methyl Methanesulfonate (IARC) N-Methyl-N'-nitro-N-nitrosoguanidine (IARC) Methylthiouracil (IARC) 1 Mitomycin C (IARC) ' Mustard Gas (IARC) 1-Naphthylamine. technical grade (CAG) 2- Naphthylamine (IARC) Nickel and Nickel Compounds (CAG. IARC) Nitrogen Mustard and its hydrochloride (IARC) Nitrogen Mustard N-oxide and its hydrochloride (IARC) 5-Nitro-o-tnluidine (NCI) 4- Nitroqwnoline-1-oude1 Nitrosamines N-Nitrosodiethanolamine (IARC) N-Nitrosodiethylarmne (DENA) (CAG. IARC) N-Nitrosodimethylamine (DMNA) (CAG, IARC) N-Nitrosodi-n-butylamine (IARC) N-Nitrosodi-n-propvlamine (IARC) N-Niirosomethvlethylamine iIARC) N-Nitrosomethylvinylamine (IARC) N-Nitroso-N-Ethylurea (NEU) (CAG. IARC) N-Nitroso-N-Methylurea (NMU), (CAG. IARC) N-Nitroso-N-methylurethane (IARC) N-Nitrosomorpholine (IARC) N-Nitrosonornicotine (IARC) N-Nitrosoptpendine (IARC) N-Nitrosopyrrolidine (IARC) N-Nitrososarcosine (IARC) Pentachloroiutrobenzene (PCNB) (CAG) Phenacetin (IARC) ' Polychlorinated Biphenyls (PCBs) (CAG. IARC) Pronamide (CAG) 1.3-Propane Sultone (IARC) , -Pn.piolactone (IARC) Propylthiouracil (TARCl ' Reserpine (NCI) 1 Sa<'<'fcT"n iron * CMA 012736 Safrole (CAG, IARC) ' Selenium Sulfld* (NCI)^ 2^T^TeU^chlorodibnIO'P'<lioxin (TCDD) (CAG) TeVachloSiSene (Perchioroethylene) (CAG, NCI) Thioacetamide (IARCV Thiourea (IARC) o-Toluidine Hydrochloride (NCI) Toxaphene (CAG, IARC, NCI) Trichloroethylene (CAG, NCI) 2,4,6-Trichlorophenol (NCI) Tris( l*aziridinvl (phosphine sulfide (ThithTEPA) (IARC, Tris(2,3-dlbromopropyl)phosphate (IARC, NCI) Trypan Blue, commercial grade (IARC) Uracil Mustard (IARC)4 Urethane (IARC) (Ethyl carbamate; ethyl ester of car- bamic acid) Vinyl Chloride (CAG, IARC) Vinylidene Chloride (CAG) ' 1 This is not a comprehensive list o( all chemicals having substan. tial evidence of carcinogenicity. Other <*enucais will be added. No attemot has been made to select chemicals based upon ap propriateness for regulation by EPA. The list is intended to be a basis for selection by the various program offices according to their 5P^WhU known carcinogen for which no report baa been prepared by Funganoxia. not an industrially manufactured product. * Evaluated by^ARC aa not having sufficient evidence of car cinogenicity. * Used as a foood. - 22 - CMA 012737 Table 7. -^^Alphabetical Index of Chemicals Cited in the NTP Annual Plan Acetamide 25 Acetin 25 Acetohexamide 36 2-Acetyl aminof1uorene 40 4-Acetyl aminof1uorene 40 N-Acetylaminof1uorene 40 Acetyl-o-toluidine ;IS Acetyl salicyclic acid Acid black 42 36 Acid orange #3 42 Acid red 25 68 Acrolein 25 Acrylamide 70 Agar agar 42, 55 Agaritine 42 Aldicarb 36, 5, 62 Allyl chloride 51 Allyl isothiocyanate 42 Ally! Isovalerate 42 2-Aminoanthraquinone 36. 51 3-Amino-9-ethylcarbazole hydrochloride 3-Amino-a,a,a-trif1uorotoluene 25 1-Ami no-2-methylanthraqui none 2-Amino-4-nitrophenol 42 2-Amino-5-nitrophenol 42 51 CMA 012737A Tris (2,3-dibromo propyl) phosphate 67 Trls (1,3-d1chlreisopy1) phosphate 67 Tris(2-ethylhexyl)phosphate 32, 50 Tris(isopropyl phenyl)phosphate 34 o-Tritolyl phosphate 32 p-Tritolyl phosphate 32 t-Tryptophan 38 Urethane 40 Vitamin A 74 Vinyl chloride 65 Vinylcyclohexane 50 Vinylcyclohexene dioxide 61 Vinylidene chloride 1, 27, 50, 56, 60 Vinyl toluene 50 Violet 3 50 Wollastonlte calcium silicates 34, 59 Witch hazel 50 m-Xylene 32, 73 o-Xylene 32, 73 p-Xylene 32, 73 Xylenes, mixed 59, 72, 73 Xylenesulfonlc acid, sodltan salt 50, 61 2,6-Xylldlne 61 Yellow #14 50,56 Zearalenone 50 Ziram 50, 56 - 46 - CMA 012738 I A. B. DeAngelo,Ph.D. Progrtun Administrator A. Hoydf BaA* Secretary --Allyl Chloride "Butylated Hydroxytoluono tpr Realm "Glycol Bthere 1 Huti-Metallic Nlnerela ""Phthalata Bsters "Vinylidena Chloride H. C. Shah, Ph.D. Director D. J. Doitas,D.S. Project Coordinator J. T. Seawell.B.S. Program Administrator f M. De Marco, B.A. Secretary ""Acrylonitrile thylene Dibromide Safety Itanium Dioxide 'richloroethylem C. R. Stack, Ph.D. Program Administrator I L. Walton Secretary --Benzene --Chlorobenzenes "Rubber Additives "Styrene "Vinyl Chloride ------Zinc Dialkyl Dithiophoephates J. C. Van Horn.H.S. ProqraW Acini nistra tor -- I T----------- D. T. Bilal Secretary 'luorocarbona n FIGUfti? 1. Organisation of Biomedical and Environmental Special Programs to to to i' CMA 10/8/80 TABLE 8 BIOMEDICAL AND ENVTROtMENlAL SPECIAL IROGRAMS BUDGET8 PROGRAM Acrylonitrile RESEARCH AND ADVOCACY COMMITMENT $ 728,484 ADMINISTRATIVE EXPENSES $ 59,411 TOTAL 5 787,895 Allyl Chloride Benzene Butylated Hydroxytoluene 210,600 1,430,444 21,944 13,948 83,526 25,213 224,548 1,513,970 47,157 Chlorobenzenes Epichlorohydrin 300,972 214,882 22,334 27,332 323,306 242,214 Epoxy Resins Ethylene Dibtomide Ethylene Dichloride Glycol Ethers -010,000 288,100 -0- 9,368 28,836 59,376 -0- 9,368 38,836 347,479 -0- Ketones Phosgene Phthalate Esters Rubber Additives Styrene Titanium Dioxide Trichloroethylene Vinyl Chloride Vinylidene Chloride -0207,912 106,471 27,900 708, H8 30,725 490,506 1,326,562 729,482 10,901 55,035 72,086 5,867 54,934 14,615 77,152 112,958 52,088 10,901 262,947 178,557 33,767 763,152 45,340 567,658 1,439,520 781,570 Zinc Dialkyl Dithiophosphates Subtotal Fluorocarbons TOTAL -0- 6,833,202 7,580,453 $14,413,655 -0- 784,983 509,214 $1,294,197 7,618,185 B.089,667 $15,707,852 aFluorocarbons program from start thru May 30, 1980. All other programs start to September, 1980. bAPI is oo-sponsoring a portion of this research. Its share ($1,587,786) is not shown in this figure. The figure does include $303,388 paid to outside legal counsel not shown on the program sumary in Appendix A. - 48 - 9/22/*i CMA 012740