Document pBeMMaRYLQVkKwqxw56KrXVpd

N *- 7/. / Hr. J. J. Norris Carbide and Carbon Chemicals Company First Floor 11 last tlst Stmt January 15, 1954 Ylnyllte 0* 8* Catbator h Instrument Corp Dear Nr* Norrisi IkNd upon what Information Is avallabia to us* as far as vlnyllta itself Is concerned, It Is quits physiologically lnart* Vo our knowledge* whanavsr ihara hava baan advarsa physiological offsets* they hava boon traeaabla to althar plastlclsars or stabilisers utilised In the composition. Host materials when placed within the body for a considerable length of time* such as semipermanent Indwelling tubas, etc.* aould cause abscess or fibrosis from mechanical trauma to the tissues* or a tissue reaction known as a foreign body reaction* Z would Imagine that such effects have been noted from the use of rubber tubing, which has been so utilised for years. The stabilisers and plasticisers utilised with vlnyllta for such applications should be those which are neither known Irritants nor eensltleers. They should also possess a low order of toxioity. This would exclude the organic tin stabilisers, and because of reputation alone* the lead stabilisers* Reviewing the plasticisers listed In the correspondence regarding the formulation, the following are brief notes on the toxicity of those plasticisers which we have studied. ec-55 tow order of acute aval toxicity* Net an Irritant or a aensltlser* A~86 Noderate acute oral toxicity, hut considered safe for proposed use* Not irritating* but was not tested via human patch teste* TOP hew order of acute oral toxicity* Nildly Irri tating to the flkla, probably a oensltiser. 0 Low order of acute oral toxicity* footed upon thirty human subjects--no sensitisation but 3 per cent primary Irritation* OI |/u\ oA 063408 Hr. J. J. Norris -8- ftnuary 15, 195* Xt is *r impression that if the cuttoner wishes to he assured of the suitability of his formulation, it would he wise to hare pieces of the finished product implanted in animals to see whether It produces injury or irritation to adjacent tissues. Wish we could give you a wore accurate opinion re garding this application and usage. Sincerely yours. KKDICAL DIRECTOR INDUSTRIAL KKDICAL AND TOXICOLOOY PKPARTNKNT Thos. V. Sale, N. D. Jl ucc 063409 ucc Hr. J. JT. Morris C& CC 6 lew York City January 11, 1?54 Albany, Hev York -b., A v ToxicWo^l,ogMyalD&a,epI4tn. dustrial Mr. Y. B. Bodes Mr. D. J. Sally 0, 8. Cathatar 4 Instrument Corp. Glana Valla, law York Saar Mr. Morrlsi. You will raeall tha writer's previous conversations with tha subject regarding tha manufacture of aathatara iron vinyl plastiaola. In tha writar*a diaouaaiona with Mr. Berman 6. Jaokal, praaidant, it waa brought aut by tha aubjaat that vinyls hava a vary bad nana la tha medical fiald baeauaa of toxielty. Ad ditional information was raquaatad by tha writer and Mr. Jaokal has kindly forwardad a latter from C. I. Bard, Xme., Summit, law Jarsay, giving their opinion ef vinyls, A eopy ef this latter la attaehad for your lnformatlan. Any eoament which Dr. Kale or yourself would eare to make would help in tha writer*e relationship with tha subject. Very truly yours. John B. Hulten/gle ucc 063410