Document pBe8b7mB2kaQbYz7OqkbmnM3X
*V.
SHELL OIL COMPANY
If
HOUSTON - HS&E - MR. J. J. BONIN
date DECEMBER 19, 1978
from
WASHINGTON REPRESENTATIVE REG. AFF. - HS&E WASHINGTON, D. C.
subject NCI DOCUMENT
Attached for your information is a document concerning "Chemicals Being Tested For Carcinogenicity" by the Carcinogenesis Testing Program, DCCP, NCI.
P. C. Holladay
Attachment
cc w/att.: Houston - HS&E - Information Services - SDC - Dr. D. E. Stevenson
U! co
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25. 2b.--------
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NOVEMBER 01, 1978
............................... ........ ............... ........................... ..
* --------------- ------- ----- ---------------- --------------- -----------
- - -
........... .............-............--
' " .......... ..................
CHEMICALS TESTED IN THIS PROGRAM ARE SELECTED ON THE BASIS OF HUNAN
EXPOSURE, PRODUCTION LEVELS AND CHEMICAL.STRUCTU82. SELECTION Of A
CHEMICAL FOR BIOASSAY DOES NOT NECESSARILY IMPLY THAT IT IS A CABCIHOCEHIC.
COMPOUNDS ARE' LISTED BY THEIR COMMON 08" GENERIC 'NAHE/
...........
__ IF THIS IS NOT AVAILABLE, - THEN CHEMICAL IfAME IS USED. FOR ADDITIONAL
INFORMATION ADDRESS REQUESTS TO: TECHNICAL INFORMATION RESOURCES BRANCH, `
NATIONAL CANCER INSTITUTE, LANDOW BUILDING, ROOM A304, BETHESDA,
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CHEMICALS ARE ARRANGED ACCORDING TO THEIR TESTING STATUS'WHICH ARE:'
TABLE I
DATA AVAILABLE
__
" IA TECHNICAL REPORTS PUBLISHED ` " " ......... ......." '................. ""
__ IB NO REPORT - DATA INSUFFICIENT
____ _ ___
`TABLE If* BIOASSAY COMPLETE - REPORTS HAVE BEEN DRAFTED
___________________ 1IA_ REPOSTS BEING PRINTED______________________
IIB REPORTS IN REVIEW............
TABLE III DIOASSAY HAS BEEN COMPLETED AND REPORTS ARE B.EING_ DBAFTED __
TABLE IV HISTOPATHOLOGY INCOMPLETE
TABLE V
BIOASSAY HAS BEGUN BUT NOCHRONIC TESTING DATA ARE AVAILABLE
TABLE VI
CHEMICALS THAT HAVE TENTATIVELY BEEN SELECTED FOB' TESTING
ABBREVIATIONS USED IN THIS REPORT ARE AS FOLLOWS:
fip.
eh.
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65. 06. 07.
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09.
90. 91.
92. 93. 9n`.------95.
96. 97. 98. '
99.
` "ROOTES OF "ADMINISTRATION:
~ ..............
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IJ - INJECTION ' ~ IP*- INTRAPERITONEAL
SP - SKIN PAINTING
Tmynccs--sfEtirs':------------------------------------------------------------------------------------------------------------------
H - HAMSTER a MOUSE R - RAT
SIMULTANEOUS CHEMICAL LISTINGS
CHEMICALS THAT APPEAR MORE THAN ONCE REPRESENT SEVERAL EXPERIMENTS.
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DATA AVAILABLE
50.
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52. 53. IA TECHNICAL' REPOSTS PUBLISHED
------ -------------------- -------- ------
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CHEMICAL NAME
57.
53. : 60.
COO 180 HEPTACHLOR C02653 HEXACHLOROPHEME
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121-75-5 FEJD 72-43-5 FEED 86-57-7 FEED
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114-06-3 FEED
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63-92-3 IP/IJ 5131-60-2 FEED
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C03292 O-PHENYLENLOIAMINt, 4-CHLORO-
95-83-0 FEED
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C00237 PICLORAM .
1918-02-1 PEED
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C00500 PROPANE, 1,2-DIBROMO-3-CHLORO-
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76.
C03554 TETBACHLOROETHANE
79-34-5 GAV
73.
COO 168 TETRACHLORVIMPHOS
961-11-5 FEED
7.8.01
CO3065 TH1 AZOLE, 2-ArtINO-5-NITRO-
121-66-4 FEED
7 3/2
CO 3 327 TOLAZAMIDE
Tl 56-19-0' FEED
78.3
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121-14-2 FEED
80.
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81.
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1582-09-8 FEED
62. * 8.3.
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126-72-7 FEED ' 64-77-7 FEED
04.
CO 17 52 UREA, 1- ( (P-CHLOROPHENYL)SUL?ONYL) - T-PROPYL-
94-20-2 FEED
35.
C04S24 UREA , N,N *-DICYCLOHEXY LTHIO-
1212-29-9 FEED '
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28.
-----
--------- ------------------ -----------
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29. 30. ;
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_ _ _______________ ______ _______ ____ CAS #
.ROUTE SPECIES
31. 1 3 2. :33.
CO 21 ,)8 O046J2 C02095
33. 1 :3tt. 34. 1 :35.
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255. 255...............
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260. 260. 1---------
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261. 262. 264. 2ti4 . 1
C04y22 C04 897 C03167 C02153
ACETAMIDE
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..................................
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L-AHGININS GLUTAMATE
AZATItlOPRINE
1,4-aUTAN-DIOL, DIKETHANESULFONATE
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CHLORAMBUCIL
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C,P1 -DDD
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DID EN20-P-DTCX1N, 1,2,3,4,6,7,8,9-OCTACHLORO-
DIREN20-P-DIOXIN
DI3SOKODULCITOL
D1BROHOMANUITOL
P-D10XAHE
qUAKACOLE
HEXANAftIDE
HYDANTOIN, DICH LORODIM ET!1 Y L-
HYDRAZINE, 1-ACETYL-2-PICOLINOYL-
HYDROXYLUREA IttIDAZULE-4-CARBOXAMIDE-5-(3,3-DIMETHYL-1-TRIAZENO)-
IMIDAZOLE MUSTARD
F1EL PH A LAN
6-MtRCAPTOPUiUNE
MERPUALAN
METHANSULFOK-M-ANISIDE, 4'- (9-ACRIDINYLAMINO)MONOHYDRO
MEIHIODAL SODIUM
METHOTREXATE
1
METHOTREXATE, DICHLORO-
METHYLTHICINOSINE
MITOMYCIN C
NITROUS ACID, SODIUM SALT PHOSPHORODIAHIDIC ACID, N,N-DIS(2-CHLOROETHYL)-N'-3-HYDBOXY
PREDNISONE
STR EPTQZOTICTN
P-TOLYLUREA
264. 3
..................... .......
"
PAGE 04
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3v;~
32.
33.
34 .
35. '
TABLE I.
DATA AVAILABLE
'IQ NO ' REPORT' - DATA* I'll S CJ F FI Cl E N T_
C04820 URACIL flUSTAHD C02119 UREA
56-75-1
.
- ....................
.......................... 57-13-6
CO 47 7 3 URSA, 1,3-BIS (CHL020ETHYL) - 1- NIT BOSO-
C04 74 0 '"URSA,"'!- (2-CHL0R02TH YLy-'3-'C YCLOHEX YL- 1-8TW6SO-
'
CO4 955 UREA, .V- (2-CHLOROSTH YL) "N* - {4-8ETHYLCYCLOHEXYL) -N-NITEOSO-
C02Q 73 UREA, (P-ETHOXYPHENYI)-
........... ............................ ..................
C04842 VINBLASTINE
.
C04664 VINCRISTINE..................................... *
**
154-93-8 *1*3010-4 7-4"
'`'150-69-6 865-21-4 57-22-7'
IP/IJ M FEED H IP/IJ _H
fi
IP/IJ a FEED H
IP/IJ N IP/IJ M
CKEMlCA'tS~'HOVSD*TO T'A'BLE IB SINCE LAST" ISSOE'
NCI t CHEMICAL NAME
CAS
ROUTE SPECIES
98. 99................... 00.
........................................' -...... ................. V
PAGE 05
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58. ____
59.
TABLE II.'""BIOASSAY COMPLETE
~ .REPORTS H A VE ' BEEN DB A PTED
50. .......................... ................................ ................ .................. ........................................
61.`
**
............ .
............... ..............
62.
IIA REPOSTS BEING PRINTED
63.
....... ..................... --................ ..
.................
64.
64.01
C03Q21 1,5-HAPUTHALSSEDlAHlXB
64.02
CO 3281 N-1-NAPUTHYLETKYLENEDIAKINE DIHYDROCHLORIDE
64.03
CO 3792 -NITHIA ZIDE'
64. o u:
C00420 NITROFEN
64.05 ...... C03952 NORPHE NAZO NE
...............
64.06
C00226 PARATHION
64.07
C03930 P-PHENYLEMEDIAMINE, DIHYDROCHLORIDE
64.08
CO 3 94 1 O-PHEKYLENEDIAMINE, 4-UITRO-
64 ; 09
'CO 2222* P-PH5NYLEHEDIAMINE"2 - NIT R 0 -
64.1
C0058B PfIOSPH AM IDOH
64.11
CO 2813 PIPERONYL BUTOXIDE
........................
64.12
CO2824 PIPEROSrL SULFOXIDE
64.13
' C04126 P1VALOLACTONS
...........' '
64.14
CO 1810 PROCARBAZINE HYDROCHLORIDE
5 4 `."16---------------CO 3907--PYRIDINE,' 2- (CHLOROMETHUy=~, "H'YDl'O'C'HXCi'fil'd'E
64.17
C02200 STYRENE
64.18"'.......... C02211 STYRENE, DETA-NITRO-v
64.19
C50022 SUEFISONAZOLE
64.2
C04240 ' TITANIUM DIOXIDE
................. ............
64.21
C01832 TOLUENE-2,5-DIAMINE, SULFATE
6 4. 22---------- ----- CO 20 4 0 '" P-TOIUI DI N 2,' 3-CHLOEO---------------------------------------------------------------
b 4.23
C02051 O-TOLUIDINE, 5-CHLORO-
64.24 ------------ C00259 TO/UPHSN2
' ' *'
64.25
C00260 TRIPHENYLTIN HYDROXIDE
64.26 -----------C03816 UREA, 1,3-DIETHYL-2-THIQ"
...................
64.27
C02017 URSA, 1-PHENYL-2-T:iIO-
o3.-7B---------------CO 7186--U.REA'"7;r;3-TRrH2TIJYI-'2-THTO---------------------------------
:65.
.-
66.
- xci I CHEMICAL NAME.....................................
.................... *
-67.
l72.
73.
J?3.~
CHEMfCTL'5~M'0'VED*~F>:oK~'TA~BL~F."IYB""SI'N'CS~ LAST .rS'SU'E
(7 6.
: 7 7. ........... ' ................... . ........... . ' ---------- ,................................ '
.......................
178.
.06. -------------- ----- -----------------------------------------------------
107. n.M
I.
PAGE 07...... .
......................... ..
"2243-62-1 FEED rt B
1465-25-4 FEED ,K
R
139-94-6 FELD 'ft
R
1836-75-5 FEED M
R
89-25-8 FEED M
R
56-38-2 FEED M
R
624-18-0 FEED MB
99-56-9 FEED M
R
5307-14-2 FEED h
A
_ J 3171-21-6 FEED rt
R
51-03-6 FEED M
B
120-62-7 FEED ft
B
"'1955-45-9 GAV " M B
366-70-1 IP/IJ ft
B
"' '
GAV ' N
8'
100-42-5 GAV M
B
102-96-5 GAV ft ' B
127-69-5 GAV M
B
13463-67-7 "FEED fl * 8
6369-59-1 FEED M
B
95-74-9 FEED M
B'
95-79-4 FEED M
R
--------8001-35-2 FEED "' R ' " B
76-87-9 FEED tt
B
105-55-5 FEED W
S
103-85-5 f EZD R
B
-------- 2*4 8 9'=lT-r2--P EE D------R B'
---------- CAS
" 'ROUTE SPECIES
1 I !
see 2000
442. 44 3.
4 44 .
TABLE IT. JlIOASSAy COWPLETt -- REPOHTS HAVE DEEN DRAFTED
443.
446.
I ZB REPORTS IN REVIEW
4]47.
4;4 9.
4j4 9.
nci a
CHEMICAL NAME
^0.
4-5 1.
C08640 ALDICARD
4i5 1 . 1
C 029 60 AMMONIUM, (2-CHLOROETHYL)TRIH2THYL-, CHLORIDE
451.11 4,'S 1. 2
C02039 ANILINE, P-CHLOROC 0 2 9 2 6 AZODENZZNE
4 52.
C08662 COUfl A PROS
453 .
050055 DIMETHYL TERIPHTHALATF.
-46 3. 1
C02B80 DIPHENUArtINE, N-NITROSO-
4,54 .
C02368 ETHANE, 1,l-D!CHLORO-2,2-BIS(P-ETHYLPHENYL)-
Up5. .............
C02857 ETHYL TELLORAC
4,5 5. 1
C02959 ETHYL TUADS
'u|56. ..........
COS 651 FENTHION
4d 7 .
C02891 LEDATE
467 .-1
CO 2971 .METHYL PARATHION
4-57.2
C 02904 'PHENOL, 2,4,6-TSICHLORQ-
4 58.
' CO 3 60 1 PHTHALIC ANHYDRIDE
4 5 8.1
C02835 SODIUM DIMETHYLDITHIOCARQAMATE
'459.'
C02335 O-TOLUIDINE HYDROCHLORIDE
..............................................
"................. *' cas a
.--
116-06-3 999-81-5 106-47-8 103-33-3
56-72-4 123-6 1-6
86-30-6 .72-56-0 30145-36-1 14239-68-0 5S-3B-9 19010-66-3 298-00-0 88-06-2 85-44-9 128-04-1 `636-21-5
ROUTE .SPECIES
FEED FEEL FEED FEED FEED FEED FEED FEED FEED FEED FEED FEED FEED FEED FEED FEED FEED
rt R nB
aR
nR na
aa
nB
rt 8
rt B aR
HB
MB
nB
rt B
MR
rt a
aB
460. 462.
463. 464. 465. '465. 1 465. 2 '466. 467. ,467 . 1
CHEMICALS MOVED FROM TABLE ITT SINCE LAST ISSUE
C02299 `ANILINE, 2,4,5-TRlHETHYLC02937 CALCIUM CARD1MIDS C03599 P-CRESOL, 2,6-DI-TERT-BUTYLC03673 DIAZINON CO 3612 PHTHALAMIDE C02302 TOLUENE-2, 4-DIAMINE C02368 ' O-TOLUIDINE, 4-CHLORO-, HYDROCHLORIDE
137-17-7 FEED rt B 156-62-7 FEED fl R
128-37-0 FEED a B
333-41-5 FEED rt B 88-96-0 PEED rt R
95-80-7 FZED a B 3165-93-3 FEED a a
473. ' 47 4. 475.
'>-i <,*>
' '
............................ ..
__
_
" ~ ..........................
___
- i.
____________ __________________ ~ .................... -.............-
PAGE^ 08___________________________ __
" r .
-tn I
I imwrta
--
?6.
4 77. 4 7 8.
479.
400.
uai. __
482.
4 0 2. 1
482.2
402.3
43 3.
483.1
484.
488.
*489'
490.
492........ ...
493.
'494 .'
499.
5To<n--------
501 .
502.'
'
503. .
ABLE mi. BIOASSAY HAS BEEN COMPLETED
"bePORTS~*ABE'BEING DflAFTED
NCI * ' CHEMICAL NAME
C03703 C03703 C03714 C03714 C50044 C 5 004 4
C00215
DI8SNZO-P-DIOXIN, 1 ,2,J,6,7,8-HEXACHLOHODIBENZO-P-DIOXIN, 1 ,2,3,6,7,0-HEXACHIORODIBENZO-P-DIOXIN, 2,3,7,8-7ElHACK LORODiasimo-?-DIOXIN, 2,3,7,8-TETRACHLOBOETHER, ars{2-CHLORO-1-METHYLETHYL; ETHER, BIS(2-CHLORO-1- METHY L ETHYL) MAL-ATHION
CREMICALS MOVED FROH TABLE IV SINCE LAST ISSUE
CC8628 II ALATHI0N-0-&N ALOG
PAGE 09
CAS S ' * BOOTS ' SPECIES
1746-01-6 1746-01-6
108-60-1 108-60- 1 121-75-5
SP GAV n SP n GAV ' ft GAV M GAV FEED ft
B
E
B a
`1634-78-2"'* FEED * "H fi
U>
see 2001
see
on.
OS. ,06.
i'J v .1*0
V.
>12 > 1)3 >14
in 11.8.
>2|0
>i2i12
;2'4 >2.5 >2'6 >27 >28 >29 >30' >31 53 2 >33 >34 >35 536, 537 530, 539 juO 54 1. >42: 543. 344 .
545. 3*46.
TABLE IIIQ. BIOASSAY HAS BEEN COMPLETED --------------------------------------- -------- ------
NCI 9 CHEMICAL NAME POSITIVE CONTROL
................ ....... *"
C00394
CO 3 349 C0V?S6 CO v;34 C03452 CO 1 4 67 C02700 CO 1423 CO 1 4 09 C0OJ62 C00373 CO 1 490
ACETAMIDE, N-FLUCREN-2-YLACETOJ1YDROXAMIC ACID, N-PLOURSN-2-YLAPLATOXI/f 01 1-BUTANOL, 4- (BUTYLNITROSAM INO)CARSON TETRACHLORIDE CYCASIN DIPENTYLAKINE, N-NITROSOGUANIDINE, 1-METHYL-3-NITRO-1-NITROSO' LEAD ACETATE
saprole
S-TRIAZOLE, 3-AHItJOURACIL, 2-THIO-
-............... ..........- -........ ~'*CAS #
fiOUTE' SPECIES
* ' ...............................'
53-96-3 FEED M R
53-95-2 FEED B
1162-65-6 PEED 3
3817-11-6 PEED B
56-23-5 GAV
MB
14901-08-7 13256-06-9
70-25-7
PEED FEED PEED
B
fi fi
301-04-2 PEED ft
94-59-7 PEED S M
61-82-5 FEED M fi
141-90-2 FEED E
________ .__________________________________ _____________ __________________ ` PAGE 10'
.trMwMlk
n.
9. .............. TABLE IV.' AS.
HI STOP AT HO LOGY INCOMPLETE
50.
51. "
NCI #
CHEMICAL NAME
5 2._________
__
5 3. '
CO 1 5 1 ^ ADRIAM YCIN ``......... ...................
54. CSudOB ASCOSOIC ACID
55`. C50011 BENZOIN
56. _ _______ C50282 2-BIPHSNYLAMINE
57. "
C50646 CAPROLACTAM
......... ........
53. C03510 CINKAHYL ANTHRANILATE
51. .................. C$4262 1, 1 - DI CiiLOBCETH YLENE
52. C 04 580 ETHYLENE, TETRACHLORO-
63 .'
-C08695 " FLUOKETURON ........... .. .
54. C50259 HEXAKSTHYLMELAMINE
56. CS3838 ORANGE 5
.....................
57. _
C 50146 4,4-OXYDIANILINE
39..........
CS3394 PLilTACH LOftOETH A NE...........
53.1
C50124 PHENOL
70*.--------------- ;--C50 157 '"RESZEPINi----------------------------------------------
71. ` C50033 SELENIUM SULFIDE
72. ----- :-------- C54546 SELSUN
73. C53907 SUN YELLOW PCF
74. ............ -- C52459 1,1, 1,2-TETRACHLGROETH A N
75._______________________ ____________________ __________________ __________________
77.
78. ' ` "
` ` ........
79.
CHEMICALS MOVED PROM TABLE V SINCE LAST ISSUE
30.
------------------------------------------------------------------ ------------- -------------------
01.
8 1 .* 1-----------------COO 500 D3C?-------------------------------------------
"
81.2
C00522 ETHANE, 1,2-DIBROKO-
81.3
C50317 TOLUEHE-2,6-DIAMlNE DIHYDROCHLORIDE
82.
83.
84.
__________________ _____
66. 87. '
...
PAGE u
-............-risU*.-------ui i
M___
CAS #
ROUTE SPECIES
2 3214-92-8 IP/IJ `
50-01-7 FEED
119-53-9 FEED
H
90-41-5 FEED
M
105-60-2 FEED ' M
87-29-6 FEED
M
75-3.6-4 ' DAY "A
___ 127-18-4__ IN HAL____ H
2164-17-2 FEED M
645-05-6 IP/IJ M
'1936-15-8 PEED
H
_101-80-4 FEED
fl
76-01-7 GAV
S
108-95-2 WATER M
-------50 -5 5-5 FEED"' M
7488-56-4 GAV
Q
' SP U
2783-94-0 PEED R
--------------------------- GAV
B'
R
R S R' B B f!
B
R
rR B
.........
-------------------INHAt
106-93-4 INHAL M E ........................FEED ` " B
1
I
m i kj cn
on on
:>33. L89. 390.
" TABLE V. BIOASSAY TESTING HAS BEGUN 3UT NO'DATA ABE AVAILABLE -------------------------------------------------------------------------------------------------------------------------
59 1 .
5^2.
NCI t CIlEWrCAL NAME
39 3. --
39". "
~ C05732 AER0Z1NE 50
.......
593.
C50475 AG A a AGAi:
596. 397.
C06999 AGA5ITIN2 C 5 0 '4 6 4 ALLl'L ISOTHIOCYANAT2
593.
C50-H3 AKtliO UNDSCANOIC ACID
3?9. 560.
C06 160 DENZYL CHLORIDE C$0635 DISPUr.NOL A
30.1.
C50602 1,3-BUTADISNS
502.
C54375 DUTY! D2KZY1 PHTHA LATE
50 3. sdu.
C53049 CARMOISINE C08639 G A :1.1A-CliLO B D AN E
5 05.
C06871 CHLORDA'IE, ALPHA ISOMER
5C6.
CS3781 C.l. DISPERSE YELLOW 3
5^7.
CS5005 CYCLOHEXANONE
sda.
C53792 D AND C RED NO. 9
: 09.
C50657 'D1ALLY PHTHAL ATE
510.
C30260 1,4-DIAMINO-2,b-DICHLOROBENZENE
611.
C$1581 CIS-1,2-DICHLOKOETHYLRNE
612.
C54591 TIiANS-1,2-DICH LORO ETHYLENE
613.
C54386 DI { 2 - ETII YLHEX Y L)ADIPATE
61^.
C52733 D1 (ZrETHYLKLXYL) PilTHALATE
61 5-.
C5U6S3 4,4' -DIPHL'NYLMETHANE DIISOCYANATE
617.
C0U626 ETHANE, 1, 1 ,1-TRICHLORO-
616.
C50384 ETHYL ACKYLATE
6 19.
C50135 ETHYLENE CHLOHOHYDBIN
620.
C50453 EUGSNOL
621.
C50 395 GUAR GU.1
622.
C50748 GUN ARABIC
62 3 .
C54364 GU.1 TASA
629.
C06893 H EPTACHLO3EPOXIDE
625.
C504 19 LOCUST BEAN GUM
626.
C50362 MANNITOL
627;"
C507 15 MELAMINE
627. 1
CO9018 METHAPYPILEKE
6 2 3. 629.
CO9013 METHAPYRILENE C54604 4,4'-METHYLENDIANILlNE 2H Cl
6 J 0.
C50102 KITHYLtNa CHLORIDE,
631.
C50680 METHYL METHACRYLATE
632.
C06428 MIRSX
633.
CO09O2 NITROFURANTOIN
634.
635.
636.
637 .
63 3.'
$ 39 -
6*40. 6 '4 1 .
PAGE 12
............................... ........... cas e
ROUTE SPECIES
57-14-7 9002-18-0 2757-90-6
57-06-7. 27323-47-3
100-44-7 00-05-7
106-95-0 85-68-7
3567-69-9 12739-03-6
5103-71-9 28 3 2t 4 0- 8
108-94-1 5160-02-1
131-17-9
156-59-2
103-23-1 117-01-7 101-69-8
71-55-6 1 40-88-5 107-07-3
97-53-0 9000-30-0 9000-01-5
1024-57-3 9000-40-2
69-65-8 103-70-1
91-80-5 * 91-80-5 101-77-9 _]- 75-09-2
80-62-6 2385-85-5
57-20-9
INHAL FEED NATES GAV FEED IP/IJ FEED INHAL FEED FEED PEED FEED FEED WATER FEED GAV FEED GAV GAV FEED FEED GAV GAV
GAV SP FEED FEED FEED FEED FEED FEED FEED FEED FEED FEED FEED GAV INHAL
FEED FEED
.M M
K M M a M a M a M M M a
n M H H S M a n n M M M n n B
H a
M M
fl
M n n a a
R B B R
R e B
R
fi
B B S R R B B R a' B a B
B E B
B B R B R R a a. . B B fi
................... ... .. ___________
(J1 K) to On on U1
.42.
.'13......
.44.
'TABLE VT' "BIOASSAY ' TESTING' HAS'BSGW'BUT" SO DATA TrF'AYXIUB EE''
----------------------------------------------- -------------------------------------------------------------------------
5 45.
.'46. ' ............. NCI t CHEMICAL NAME.......... .............................. ..
CAS *
ROUTE ' SPECIES
'I 7.
i48. "
CSJ838 OB A NC E C
1936-15-8 FEED ' a `_'
>4 9 . C50124 PHENOL )30 . C 5 6 4 1 4 PH N YLBUTAZON
108-95-2 INHAL H WATER '.a
R
iSI. C50077 PROPYLENE
1 15-07-1 INHAL a B
.52. C50099 PROPYLENE OXIDE
75-56-9 INHAL a R
;53, C505B9 PROPYL GALLATE
121-79-9 FEED a R
15 u. C04035 RANDOX
93-71-0 FEED M B
55. C02722 STANNOUS CHLOHIDE
7772-99-8 FEED a B
56."
C54977 STYRENE OXIDE
96-09-3 GAV R
.57. C53929 SUDAN 1
842-07-9 FEED n B
.59. C53907 SUN YELLOW FCF
2783-94-0 FEED a
>59 . C03995 TELONE
S42-75-6 GAV
aR
>6 1. C50533 TOLUENE 2,4-DIISOCYANATE
S84-84-9 ' GAV- a B
562.
C04546 TRICHLOROETHYLENE
79-01-6 GAV
a
5531 C50226" ZEARALENONF >64. ' C50442 ZIRAtl
'.
/64b-^J-U FEED' H fi
137-30-4 PEED a B
>65. "
' ............... . '
6 6. >67.
**
>68.
568. 1 ' >6 6.2
CHEMICALS 'MOVED FROM" TABLE TTSINCE LASTTS'SUlf -------.------
569.
569.01
C54911 ACID ORANGE S3
FEED
569.02
C54717 ALLYL ISOVALEBATE
" .................... 2835-39-4 GAV
559.03 565.04
C50.179 AMYL NITRITE ' CO6508 ' BENZYL ACETATE'
110-46-3 GAV '140-1 1-4 "GAV '
56.9. 05
CS5130 SKCMOFORM
75-25-2 GAV
569.06
C55367 T-BUTYL ALCOHOL
- ------ --------- '......... 75-65-0 WATER
569.07
C5S 163 CASTOR OIL
8001-79-4 PEED
569.08
C55254 CHLORODIDRCMOMETHANE
................... .......... 12 4-4 8- 1 GAV
569.09
C54820 3-CilLORO - 2-ttETH Y LPfiOPEN E
563-47-3 GAV
569. 1 --------- C55265 CULORPHSNIRAHINE MALEATE '
i n-92-8 ' FEED
569.11
C 5 5 3 12 COCONUT OIL ACID DIETHANOLAMINE (CONDENSATE 2/1)
SP
569.12
C50737 CYTEttiiEilA
...... .......... "2126-70-7 IP/ZT
>59.13
C54944 0-DICULORO3EHZENE
, 95-50-1 GAV
569.14 569.15 -
C54953 P-DICHLO RODENZENE C55141 1,2-DICHLORCPSOPANE,
*.............. ....... --------- -------------------- 106-46-7 GAV I 76-07-5 GAV
559. 16tjMW1----- C55174 ' DIETHANOLAMINE " '*
-----
-^111-42-2" WATEB
569. 17
C54966 DIGLYCI DYLnESOP.CINOL ETHER
=69.18
C55129 N,K-DIMTI1YLD0DECYLAMINE OXIDE '
' ......... .. .....
1643-20-5
569. 19
C54773 DIKF.ril YLHYDPOGEN PHOSPHITE
GAV
569.2 "
C54762 DIMETHYL KETHYLPHOSPHONATE
............
..... ........
GAV
569.21
C5U740 DIM ETH Y LMORPHOLINOPHOS PilON ATE
GAV
569. 22 ---------- ' C 54 8 19 DlMETil YLVINYLCKLORIDE
513-37-1" GAV
669.23
C54900 DISPERSE BLUE Si
2475-45-8 PEED
669.231
C54875 DODECYL ALCOHOL, ETHOXYLATED
FEED
66S.24
C548S3 ETHYLZNE GLYCOL MONOLTHYL ETHER
669.25 ---------- C 5 4706 "P LlJOR ESC El N, DISODIUM SALT '
-- ... . * ` " ---'* ' ---------------------- -------
110-00-5 WATEB 518-47-0 WATER
669.26
C54726 GERANYL ACETATE
105-07-J GAV
U11 K) 0] on on
65.273 69.274 TABLE V. 69. 27S_______
BIOASSAY TESTING HAS BEGUN BUT NO DATA ABE AVAILABLE ----------------- ----------------------------------------------- -------------------- --------------------------
69.276 ' *
.......................
" " .......................... *
69.277
CHEMICALS MOVED FROM TABLE VI SINCE LAST ISSUE
69.27B
---------------------------------------------------------------------------------------------------------
69.279 69.2Q 69.29
C54897 UC BLUE 32 C54922 KC STD #3
.. ..............................
69.3 69. 3 \ 69.3 2 59.33 69.34 69.35 65,36 69,37 69. 3 B 69.39 69. 4 69. 41
C55290 C55323 CS4660 C54142 C54626
C02846 CO 29 15 C54784 C55334
C5S209 C54933 C54637
8-KYDORXYQUINOLINS LAURIC ACID DIETHANOLAMINE (CONDENSATE 1/1) MALEIC.KYDRA2IDE DIETHANOLAMINE SALT MALONALD2HYDE MOLYBDATE ORANGE MONUBON 2-NAPKTUYLAKlNE, N-PHSNYLNAVY FUELS JP-5 (PETROLEUM DERIVED) OLEIC ACID DIETHANOLAMINE (CONDENSATE VD OXALIC ACID PENTACH LOP.O PHENOL
PHTHAL0CYANIN2 SHEEN
.
69.42 69.43
CS5301 PYRIDINE C54739 P-ROSANILINE
69. 4 69.45 59. 46 69. 47 69.43
C55210 C50191 C50204 CS5221 cS49a '
SOTEXONE SODIUM DODSCYL SULFATE SODIUM (2-ETHYLHEXYL)ALCOHOL SODIUM fLUOP.IDS TETRAETHYL LEAD
SULFATE
*
69 i 4 9
C55061 TMPC
69.5
C55050 THPS
59. 51 69. 52 6.9.5 3
C54831 TRICHLOSFON * C54751 TRIS (2-ETHYLHEXYL)PHOSPHATE
C54999 VINYLCYCL0HEX2NE
.65. 54
C54659 VIOLET 3
.69.55 .70.
C55232 XYLENES
*71,72. ...... 7.3.
i 7 H.
>7 S. ,76.
,77. ,70. ,79.
;ao:
__ *" ,
,31. >8-2. >33.
;aa-
~
>85.__________
, a b.
we--nr
FEED
FEED
148-24-3 FEED 120-40-1 . SP 5716-15-4 WATER
542-78-9 GAV
12213-61-5 1 50-68-5 135-80-6
PEED FEED FEED
SPIG
SP
144-62-7 FEED
87-86-5 FEED 1328-53-6
GAV
569-6 1-9 FEED 83-79-4 FEED
151-21-3 126-92-1 7681-49-4
70-00-2 124-64-1
FEED f ELD WATER GAV
FEED
feed
52-60-6 PEED
78-42-2 GAV GAV
FEED 1330-20-7 GAV
U1 l
w o o
If) n
n
vj
,87. id a. >Q`J.
TABLE VI. *C EE MICXL5 THAT HAVE BEEN TENTATIVELY SELECTED"'FOR 'TESTING'
>9 0. >91. >92. >94. i96 . >9 6. 1 >95.2 >9 7. >99. >99. 1 '00 . '02. 10 3. '04 . 705. 706 . '07. 709." 7 10. 7 11. 713. 714. 7 15. 7161 716. 1 717. 716. 721. 722. 72."-- 72.7. 726 . 729 . 730. 733. 734 ; 737 .
...... .
NCI # CHEMICAL NAME
C50215 ACRYLONITRILE C55458 1-AKINO-2,4-D2BBOKOANTKRAOUINONE
2- AillHO-y-HI T B 6 P H ENO L
2-A MI NO-5-NITROPHENOL
C5571U AMPHETAMINE
... .
...........
C55152 ANTIMONY OXIDE
AZODICAP.BONAMIDE C55276 BENZENE
........................ ".........
...... ..
C06111 BENZYL ALCOHOL '
~ ------------------------------------ --------
C55516 2.2-313 (3P.OMOETHYL) -1,3-PROPANEDIOL
CO 4 159 C54615 C5S492 C55243
N 1 , N'-B13 {2-HYDROXYETHYL) -N-METH YL-2-NITBO-P- PHEN YLENE Dl'
BLUE ISO
DROHO!52,4N'2ENE
---------------------------------------------------------
BSOMODICHLOHOMETHANE
C50522' 1.3-BUTADIENE, 2-CKLORO---------------- :-------------------------------------!---------------------
C55447 2-BOTANONE PEROXIDE
BETA -C A DIN ENE
---------------------- ------------------ "" "
C55072 CHLORENDIC ACID
C55754 CHLORINATED TfilSODIUH PHOSPHATE.....................".....................
'
C55107 CHLOROACETOPHENONE (CN)
C5 5709' "CKLOROAM PHfcHICOL
P-CHLOROANXLINE
C 5 5 1 18 CHLORODENZALMALONONITRILE AND HEXAMETHYLDISILIZANE (CS2)-
C54886 CHLOROBENZENE
C53543 CMLOROa'AX 40
' -----------------------------
C 5 3 587 CKLORCVAX 500C
CHLORPROMAZINE -------------------------- -------------------------------------------------
CS5207 DECABROMODIPHENYL OXIDE
C50168 DEODORIZED WINTERI2ED COTTONSEED OIL .................................
C54795 DFM
C 5 5 4 36 2.3-DIDRO.MO-1-PHOPANOL
...........................................
CIS-DICHLOFO.DIAMINE PLATI NUK (II)
"C55345 ~2','4-DICHL030 PHENOL*"------ ----------------------------------------------------------------
CO 0271 DIETHYLWITBOSAMIKE
740.
PAGE IS
CAS It
BOOTS SPECIES
"107-13-1
......... "
J309-64-4.............. 71-43-2 GAV
574-93-6 FEED 75-27-4 GAV
T2 6^99-13-------------- -
115-28-6_ 532-27-4
108-90-7 51990-12-6 56509-64-9
1163-19-5
"120- 8 3-`2' FEED----------
55-18-5
H
Ti.-Hi
+****PtH\
* :
41.
42. ...........TTAABBLLEE VVII..' CHEMICALS THAI HAVE SEEN TENTATIVELY SELECTED FOB TESTING. 43.
'44 .
45.
'4 6.
54."
'55.
'56.
'57.
'58.
'59.
'60.
'6K
'62.
'65.
'67.
'67. 1
'70.
'71.
74 . '74. 1
'75.
'76.
'77. ' ----------
na.
'30`. '
/ar.
fan.
.......
>85.
786.
'
>87.
?8a.
739.
790. " ........
793.
NCI * CHEMICAL NAME
C55652 EPKEDRINS
................
C07001 AL?HA-E?ICHLOROHYDHIN
C55663 "EPINEPHRINE
C55527 1.2-EPOXYQUTANE C55538 1.2-?0XYHEXADCANE
C5SL74 ERYTHROMYCIN C00522 ETHANS, 1,2-DIBR030-
C06213 C50066 C5008B C02799.
ETHYL BROMIDE "ETHYLENE
ETHYLENE OXIDE FORMALDEHYDE
C55425 C55549 C55607
FlfROSSKIDE
GLUTAFALDEHYDE
GLYCIDOL
-___
' HEX ACii LOROC YCLOPE NTA'DI ENE
HEXA METHYL-p-HOSANILINE
C55618 C55630 C55572' C54648
C55685 C00726 C55721 C55594
hexylsesobcincl
HYDSOCHLQROTHIA2IDB 1 SOPHOSOH ISOPROTERENOL HCL _____________ 'D-LIHUNENE............... ..
LITHOL RUDINE ALPHA-METHYL BENZYL ALCOHOL 2 0 - M 2T H Y LC K 0 L A NT H R E N METKYL-DOPA METHYL CARBAMATE
C55629 C50102 C5S550 CO 2164
"methyl chloride METHYLENE CHLORIDE
METKAPYHILENE MORPHOLINE, 4-NITROSO-
79 6.
PAGE 16
CAS f
ROOTE SPECIES
106-89-8 INHAL ,;H
106-93-4
74-85-1 75-21-8 50-00-0
INHAL INHAL
fl M
B R
5281-04-9 56-49-5
_7 5- 09-2___IH HII___fl____ R: 59-89-2
n c.WLB
I.
see -2 0 0 8
see 2009
17 . 36. TA3LE VI. CHEMICALS THAT HAVE BEEN TENTATIVELY SELECTED FOR TESTING: 99.
09.
0,1. NCI ft
0'2.
03. C55049
Q4. C00306
05. C05050
0:6. C55583
0,7 C50130 0,3. CO 203 4 09 . C 5 4 5 0
1 >. C5-5 4 ,9
H3. C03935
1,5.
C55743
16. ' C 556 41
1,7. ib.'
*' C00237
2'A. C50339
24." '
C 50566
25. C5.5505 26. C55732
30. C55696
31.---------
C55561
32.
4 O . C04546
38; C03327
.39. " *..... ------ C50373
42. C55470 43. -------- "*---
44.
CHEMICAL HAKE
NAVY FUELS JP-5 (SHALE OIL DERIVED)
NITROGEN DIOXIDE
_ ___________
N-NITROSODIMETHYLAMINE
N-NITROSODIETHANOLAMINE
NITROUS ACID, ETHYL ESTER
NITROUS ACID, SODIUM SALT
NON - D-iO DOh 12 ED WINTERIZED COTTONSEED OIL
OHGAMIDIN
___________________________________
PARAFFIN OIL
........
....... ...
PENT A EflITli RITOL TETRANITRATE
PHENCLEPHRINE HCL `
............... ...
........... ..........
PUSH YTOIN SODIUM
P1CL0RAM
......................... .
"
RAUWOLFIA SERPENTINA
SIMETHICONE
.....
Sodium aluminosilicate SODIUM DICHLOitOISOC YANURATE
.................... ........................
SUCCINIC ANHYDRIDE
TETRACYCLINE HYDROCHLORIDE "
TETSANITROMETH ANE
TRICHLOROETHYLENE
----------------------
UREA, 1 - (HEXAHYDHO - 1H** AZEPIN- 1 -YL) -3- (P-TOLYL_SOLPONYLj
. VISYLDB0J1IDE
.......... ........... .......................
WOLLASTOHI.TE KC YELLOW NO. 4......................... ..
- --
;4 0.
sS. - - - - - - - - - - - -
...
ISO.
CHEMICALS ADDED TO TABLE VI 5INCE LAST ISSUE
152. ----------- ----
153.
CS5903 8-HSTHOXYPSORALEN
153.1 ---------------------------------- NITROPUEAZONZ ` ------------------------------------------------
153.2
DIPHENHYDRAMINE HCL
153.3 "
AKPICIILIW
153.4 153.5 ..............................
PROBENECID BENZATHINE PENICILLIN G
153. 6
CIKNAMALDEHYDE
15 3.7 "TTClv----- ----- ------------- miODAHIME 6G------------TT---------------------------------------
153.8
3E!IZALDUiYDE
cn l
153.9 154.
` INDOKiTHACIN
........................... ............
2,4,6-TRINITROTOLUENE
354.1
'" ' ' '
EENZOFURAN
...............................
154.2
FUR FUR AL
154.3 --------------------------------- 2,6 -XYLIDTNE-----------------------------------------------------------
154.4
NALIDIXIC ACID
3 54.5
FU3AN
"
..........
154.6
DIM2TH0XAN3
354.7' -- ------------ --- -------------- FURFilRYL ALCHOL' ---------
36 3 .
"
.......... ..
16 .
~
CAS t
ROUTE SPECIES
10102-44-0 62-75-9
109-95-5 7632-00-0
~S'01'2-9'5-f
8063-17-0
"boso^st-t
------79-01-6--GAY----1156-19-0 " 593-60-2" INHAL
iimti
4i
CHEMICALS BEING TESTED FOR CARCINOGENICITY BY THE CARCINOGENESIS TESTING PROGRAM, DCCP, NCI
I \ **
. JV
CHEMICALS TESTED Jn THIS PROGRAM ARE SELECTED ON THE BASIS OF HUMAN
EXPOSURE, PRODUCTION LEVELS AND CHEMICAL STRUCTURE. THEY SHOULD NOT BE CONSIDERED AS SUSPECTED CARCINOGENS BY VIRTUE OF BEING IN THE TESTING PROGRAM. COMPOUNDS ARE LISTED DY THEIR COMMON OR GENERIC NAME, IF THIS IS HOT AVAILABLE, THEN CHEMICAL NAME IS USED. FOR ADDITIONAL INFORMATION ADDRESS REQUESTS TO* TECHNICAL INFORMATION RESOURCES BRANCH NATIONAL CANCER INSTITUTE, LAHDOW BUILDING, ROOM A304, 6ETHESDA, MARYLAND SoHlS?
^ On
see -2 0 1 0
see -2011
* ''X',
CHEMICALS ARe ARRANGED ACCORDING TO THEIR TESTING STATUS WHICH ARE:
TABLE I
DATA AVAILABLE
IA TECHNICAL REPORTS PUBLISHED
IB NO REPORT - DATA INSUFFICIENT
TABLE II
BIOASSAY COMPLETE - REPORTS HAVE BEEN DRAFTED
IIA REPORTS BEING PRINTED
IID REPORTS IN REVIEW
TABLE III BIOASSAY HAS BEEN COMPLETED AND REPORTS ARE BEING DRAFTED
TABLE IV
HISTOPATHOLOGY INCOMPLETE
TABLE V
DIOASSAY HAS BEGUN BUT NO CHRONIC TESTING DATA ARE AVAILABLE
TABLE VI
CHEMICALS THAT HAVE TENTATIVELY BEEN SELECTED FOR TESTING
ABBREVIATIONS USED IN THIS REPORT ARE AS FOLLOWS*
ROUTES OF ADMINISTRATION*
FEED - ORALLY WITH FOOD GAV - ORALLY BY GAVAGE IHHAL - INHALATION WATER - ORALLY WITH WATER ANIMALS SPECIES*
H - HAMSTER M - MOUSE R - RAT
IJ - INJECTION IP - INTRAPERITONEAL SP - SKIN PAINTING
SIMULTANEOUS CHEMICAL LISTINGS CHEMICALS THAT APPEAR MORE THAN ONCE REPRESENT SEVERAL EXPERIMENTS.
* <>. Lfl
i
'I
-I ----
M
*
-\DLG -I. DATA AVAILABLE
IA TECHNICAL REPORTS PUBLISHED
NCI fl
Cls3974 Cf-2766 CP1445 CM665 C( A 137 CfOO'i* CL 1 7 07 CG 1 730 CO 1 923 CO 1569 C006 19 C02666 Cf 0077 CC0055 Cf 0099 CI O tot Cl 2686 CC 1718 C(1989 C(3269 CC 0 113 CIO 126 Cl 0 126 C(3599 0(3135 C(1605 CC 0566 0(6626 Ct 6580
CHEMICAL NAME
ACETIC ACID, (ETHYLENEDIHITRILO)TETRA, TRISODIUM SALT ACETIC ACID, NITRILOTRIACETIC ACID, NITRILOTRI-, TRISODIUM SALT, MONOHYDRATE ACETIC ACID, NlTRILOTRI-, TRISODIUM SALT, MONOHYDRATE ACRIDINE, 3,6-DIAMINO-,MONOHYDROCHLORIDE ALDRIH ANILINE, 6,6 *-TIUODIANTHRAHUIC ACID AMTIIRAQUINONE, 2-HETHYL-1-NITRO5-AZAC.YT1DINE BENZENE, PENTACHLORONITRODIPHENYL, CHLOROCAPTAII CHLORAMBEN CHLORDAHE CHLORDECONE CHLOROFORM DAPSONE 2,4-DIAMINOANISOLE SULFATE DIARYLANILIDE YELLOW DICHLOROVOS DIELDRIN DIELDRIN DIELDRIN, PHOTODIMETHOATE EMETINE EHDOSULFAH ETHANE, 1,1,1-TRICHLORO-ETHYLENE, TETRACHLORO-
PAGE 01
*i i.w
cn
i hJ 1/3
on H> O
N
fr.
CAS 0
150-38-9 139-13-9 18662-53-8 18662-53-8 952-23-8 309-00-2 139-65- 1 1 18-92-3 129-15-7 320-67-2 82-68-8 27323-18-8 133-06-2 133-90-6 57-76-9 163-50-0 67-66-3 80-08-0 39156-61-7 6358-85-6
62-73-7 60-57-1 60-57-1 13366-73-9 60-51-5
683-18-1 115-29-7 71-55-6 127-18-6
ROUTE
FEED FEED FEED FEED FEED FEED FEED FEED FEED IP/IJ FEED FEED FEED FEED FEED FEED GAV FEED FEED FEED FEED FEED FEED FEED FEED
IP/IJ FEED GAV GAV
SPECIES
M ,, R M 'R 11 R MR MR MR MR MR MR MR MR R MR MR MR MR MR MR MR MR MR MR
R MR MR MR MR MR MR
KNTIS (1
P0270938-AS PB266177-AS PB266177-AS PD266177-AS PB260553-AS P D 2 7 5 6 6 6 - A f> PD2S0360-AS PB278883-AS PI3277 6 3 9- AS PD279526-AS PB28 1732-AS PB279620-AS PB273675-AS . PB273065-AS PB271977-AS PB266061-AS P B 2 6 6 0 10-AS PB276396-AS PB279960-AS PB273272-AS PB270937-AS PB275666-A5 P0275676-AS
PD276393-AS PD266367-AS
PD27839l-AS PB26173i-AS PB265082-AS PD272960-AS
i
I
*
....................*
TABLE I
DATA AVAILABLE
IA TECHNICAL REPORTS PUBLISHED
MCI ft
CHEMICAL NAME
CO0180
C0 26 5 3 (.0 1567
C0 1638 CO 1678 ( 00206
C00215 C00697
C00620
CO 176 1
C00237 C00500
C03076
C:0 1785 C 03556
C0 1865 CO0168
CO6566
C00462 C03270
C0 1763 C01752
C04524
HEPTACHLOR
HEXACfiLOROPHENE IPD
ISOPHOSPHAMIDE LASIOCARPIHE LIMDAI1E
MALATHIOH METHOXYCHLOR
NITROFEH
PHEHF.ORMIH
PICLORAM PROPANE * 1,2-DIBROMO-3-CHLORO-
PROPIONIC ACID, 3-NITRO-
PYRAZIHECARDOXAMIDE TETRACHLOROETHAHE
TOLUENE/ 2,6-DIHITROTETRACHLORVINPHOS
TRICHLOROETHYLENE
TRIFLURALIM TRIS (2,3-DI8R0M0PR0PYL >PHO$PIIATE
UREA, 1-BUTYL-3-(P-TOLYLSULFONYL)UREA, 1-<(P-CHL0R0PHENYL)SULF0NYL)-3-PR0PYL-
UREA, N,N'-DICYCLOHEXYLTHIO-
PAGE 02
- t i
76-66-8
70-30-6
3658-22-0
3778-73-2 303-36-6 58-89-9 121-75-5
72-63-5 1836-75-5
1 16-86-3
1918-02-1 96-12-8
506-88-1 98-96-6
79-36-5
12 1-16-2
96 1-11-5 79-01-6
1582-09-8 126-72-7
66-77-7 96-20-2
1212-29-9
FEED PEED IP/IJ IP/IJ FEED FEED FEED
FEED FEED FEED FEED GAV
GAV FEED GAV FEED FEED GAV FEED FEED
FEED FEED FEED
M R
M M R M M
M M M M M
M M M fi
n 11
11 M M M M
R
R R
R R R R R R R R R R R R R R R R R R
PD27 1967-AS
PB279525-AS P D27 76 55 -A 5
P0275677-AS
PD278661-AS nr;:/3630-A5 PB270527-AS
PB278271-AS
PD277660-AS
PD266176-AS P D 2 7 6 6 7 1 -AS PB277672-AS
PD28 1 102-AS - PD23025 1-AS
PB277653-AS
PB280990-AS PD278650-AS
PD266122-AS PD278610-AS
PD280271-AS PB276683-A5
PDS^SUfi-AS PB281539-AS
ABLE I. DATA AVAILADLE
IA TECHNICAL- REPORTS PUBLISHED
NCI ft CHEMICAL NAME
CHEMICALS MOVED FROM TABLE IIA STNCF LAST ISSUE
CO 1536
03065
C >16(53 CO 15B 1
C34557 C34579 C54568 C04535 C 0 46 0 4 CO 1956 C03292 CO 1558
C04579
ACROHYCIME 2-AMIII0-5-NITR0THIA20LE PARAPRIM
BETA-DEOXYTIIIOGUAHOSINE DIRECT BLACK 38 DIRECT BLUE 6
DIRECT-BROWN 95 ETHANE,1,t-DICHLORO HEXACHLOROETHANE NAPHTHALENE, 1-NITRG-
O-PHENYLENEDIAMINE, 4-CHLORO-
PHENESTERIH 1, 1,2 TRICHLOROETHANE
''
l
CAS ft
ROUTE SPECIES
7008-42-6 121-66-4 58-14-0 789-6 1-7 1937-37-7
10300-74-0 106-93-4 67-72-I 86-57-7 95-83-0
3546-10-9 79-00-5
.
ip/ij FEED FEED IP/IJ FEED FEED FEED GAV GAV FEED FEED OAV GAV
MR MR
MR HR MR MR nR MR MR MR MR M * R-
XHTIS
PB283347-AS PB283346-AS PD282608-AS PB20154 0-AS PD280204-AS PD280204-AS PD280204-AS PD283345-AS PB282668-AS PD282310-AS PB283362-AS PB283361-AS PB283337-AS
K NOTE* THESE ARE THE ACCESSION CODE NUMBERS TO BE USED IN OBTAINING NCI TECHNICAL REPORTS FROM THE NATIONAL TECHNICAL INFORMATION SERVICE, US DEPARTMENT OF LABOR, 5285 PORT ROYAL RD. SPRINGFIELD VIRGINIA 22161 TEL* (703) 557-4650
PAGE 03
m
See
^*nViai4Ti-iignrt)
ABLE I. DATA AVAILABLE IB HO REPORT - DATA INSUFFICIENT
t:ci fl
C 04682 C 04 728 C 0 347 4 C 0 1592 C 0 4 8 08 C03485
C04900 C04693 C04933 C03667 C03678 C03656 C04795 C04762 C03S89 C 048 19
C0 3054 C04739 C0483 1 C04717 LO 16 16 C04853 C04886 C04 944 C 0 3 190 C0467 1 C0487 5 C04784 C047 0 6 C04922 C04897 CO 1810 C03167 C04320 C04773 CO4740
C04T$*3 C04842 C04864
CHEMICAL NAME
ACTINOMYCIN D ARABIH0SYLCYT05IHE AZATII/OPRIHE
14-BUTANEDIOl, DIMETHANESULFONATE CARBAHILIDE* 4,4-DIACETYL-BIS(AMIDINOHYDRAZONE),DIMETHANE CHLORAMBUCIL
CYCLOPHOSPHAMIDE DAUHOMYCIN. 0 P* -ODD DIBENZO-P-DIOXIH, 2,7-DICHLORODIOENZO-P-DIOXIN, 1,2,3,4,6,7,8,9-0CTACHL0R0DIDENZO-P-DIOXIN DIBROMODULCITOL DIDROMOMANNITOL P-DIOXANE GUAHAZOLE HYDANT01N, DICHLORODIMETHYLHYDRAZINE* 1-ACETYL-2-PICOLINOYLHYDROXYLUREA IMIDAZ0LE-4-CARB0XAMIDE-5-C3, 3-DIMETHYL-1-TRIAZENO)IMIDAZOLE MUSTARD MELPIIAIAH 6-MERCAPTOPURINE MERPHALAH METHANSULFON-M-AHISIDE, 4'-(9-ACRIDINYLAMINO) - , MOHOHYDRO METHOTREXATE METHOTREXATE, DICHLOROMETHYLTHIOIMQSINE
MlfOMYCIN C PHOSPHORODIAMIDIC ACID, H,H-BIS(2-CHL0R0ETHYL)-N'-3-HYDROXY PREDNISONE PROCARBAZINE HYDROCHLORIDE STREPTOZOTICIH URACIL MUSTARD UREA, 1,3-BIS( CIILOROETHYl) - 1-HITROSO-
UREA, 1-C2-CHL0R0ETHYL)-3-CyCLOHEXYL-1-NITROSO UREA, N-C2-CHL0R0ETHYL)-'-(4-METHYLCYCLOHEXYL)-N-NITROSOVINDLASTIN6 VINCRISTINE
CAS ft
50-76-0 147-94-4 446-86-6
55-98-1 15427-93-7
305-03-3 50-18-0
1407-15-4 53-19-0
33857-26-0 3268-87-9 262-12-4
10318-26-0 488-4 1-5 123-91-1 503-88-8 1 18-52-5
17433-31-7 127-07- 1
4342-03-4 5034-77-5
148-82-3 50-44-2
59-05-2 528-74-5 342-69-8
50-07-7
53-03-2 366-70-1 18883-66-4
66-75-1 154-93-8 130fl0-.-47-4
865-21-4 57-22-7
ROUTE SPECIES
1P/IJ IP/IJ IP/IJ IP/IJ
IP/IJ IP/IJ IP/IJ IP/IJ IP/IJ SP
SP SP IP/IJ IP/IJ SP
IP/IJ FEED IP/IJ IP/IJ IP/IJ IP/IJ IP/IJ IP/IJ IP/IJ IP/IJ IP/IJ IP/IJ IP/IJ
IP/IJ IP/IJ IP/IJ IP/IJ IP/IJ IP/IJ IP/IJ
IP/IJ IP/IJ IP/IJ IP/IJ
M M M M M
M M M M M M
M M M M
M M M M M M M M M M M
M M
M M M M
M
M
M M
M M
R R R' R R R R R R
R R
R R R R R R R R R R R R R R R R R R R R R: R R R
see 2015
PAGE 04
TABLE II. BIOASSAY COMPLETE
REPORTS HAVE DEEN DRAFTED
IIA REPORTS BEING PRINTED
NCI ft
CO 1887 C02993 CQ46 15 co ms CO 1 901 C02697 CO 352 t C00533 CO 166 1 C036S9 C00395 CO 1570 C0C522 C005 1 1 C 0 16 9 A CO 1854 CO 3258 C04568 C00431 C03316 CO 1672 CO 1649
CHEMICAL NAME
ACETANILIDE, 3-AMIIIO-4-ETHOXYP-ANISIDINE, 2-METHYL-
ALLYL CHLORIDE ANTHRANILIC ACID, 4-NITROANTHRAQUINONE, 1-AMINO-2-METHYL- ' AriRIH, PHEHACETIN AND CAFFEINE 1H-DENZOTRIAZOLE CHLOROPICRIN DIDENZYLINE HYDROCHLORIDE P-DI.OXANE DIOXATHION ESTRADIOL MUSTARD ETHANE, 1,2-DIBROMO-
ETHANE, 1,2-DICHLOROETHIOHAMIDE HYDRA2IME, t,2-DIPHENYLHYDROXYLAMINE, N-NITROSO-N-PNENYL-, METHANE, TRIIODONICLOSAMIDE P-PHENYLENEDIAMINE, 2-CHLOROPYRIDIUM THIO TEPA
AMMONIUM
SALT
PAGE 05
CAS ft
ROUTE SPECI
102-50-1 107-05-1 6 19-17-0 82-28-0 8003-03-0
95-14-7 76-06-2 6 3r92-3 123-91-1 78-34-2
106-93-4 107-06-2 536-33-4 122-66-7 135-20-6 75-47-8 1420-04-8 615-66-7 136-40-3. 52-24-4
FEED GAV GAV FEED FEED FEED FEED GAV IP/IJ WATER FEED GAV GAV GAV FEED FEED FEED GAV
FEED FEED
FEED IP/IJ
MR
MR HR
MR
MR
MR MR MR
MR
MR MR MR MR
MR
MR If R MR MR
MR MR MR MR
i
\DLE II . BIOASSAY COMPLETE -- REPORTS HAVE BEEN DRAFTED IIA REFORTS BEING PRINTED
NCI t
C03305 C9Z233 Cl 1627 0)3527 C -'.557 C 13741 CU 1729 C03247 CO 3327
CHEMICAL NAME
H-PHENYLERGOTAMINE, 4-CHLORO P-PHEHYLENEDIAMIHE, N-PHEHYL-, HYDROCHLORIDE 2, 6-PIPERA2INEDI0HE-4, A*-PROPYLENE DIOXOPIPERAZINE SUCCINIC ACID, MONOC2,2-DIMETHYLHYDRA2IDE)TltiUPHENE, 2,5-DIIIYDRO-, 1,1-DIOXIDETRIMETHYL PHOSPHATE TRYPTOPHAN, LUREA, 1-((P-ACETYtPHENYL)SULFONYL)-3-CYCL0HEXYLUREA, 1-CHEXAHYDRO-1H-AZEPIH-1-YL)-3-(P~TOLYLSULFONYL)-
CHEMICALS MOVED FROM TABLE IIP SINCE LAST IS5UE
CAS R
513 1-60-2 2194-59-6
1596-84-5 77-79-2
512-56-1 73-22-3
968-41-0 1156-19-0
ROUTE
FEED IP/IJ FEED GAV FEED FEED FEED FEED
SPECIES
M., R MR MR MR MR M. R MR MR
CO 1967
C03736 C--I3684 Ci 1934 C--3032 O'' 1576 C `0066 Ci 1394 C 0 4 04
C 343A C-2952 C: 0102 C` 0544 Ci 3021
Ci 3952
Ci.0475 Ci:0555 CO0464 CU0453 Cf; 1332 002040 CO 026 0
CO 201Itf.
ACEHAPHTMENE, 5-NITRO-
ANILIHE CHLORIDE
AHILIZIDE
O-ANISIDIHE, 5-MITRO-
AN1SOLE, 2,3,5,6-TETRACHL0R0-4-NITR0-
ANTNRAQUIHONE, 2-AMINO
A2IHPHO3-METHYL
CARBAZ0LE, 3-AMIM0-9-ETHYL-, HYDROCHLORIDE
CIIL0R03EHZILATE
3-(CHLOROMETHYL)-PYRIDINE HYDROCHLORIDE
P-CRESIDINE
DACUHIL
MEXACAROATE
1,5-HAPHTHALEMEDIAMlNE
NORPHEHAZONE
P,P,-DDD
P,P*-DDE
P,P* -DDT
SULFALLATE
TOLUENE-2,5-DIAMINE, SULFATE
P-TOLUIDINE, 3-CHLORO-
TRIPHENYLTIN HYDROXIDE
UREA, 1-PHENYL-2-THIO-
'
602-47-9 FEED 142-04-1 FEED
101-05-3 FEED
99-59-2 FEED 2434-45-2 FEED
1 17-79-3 FEED 46-50-0 FEED
FEED
510-15-6 FEED GAV
120-71-4 FEED 1497-45-6 FEED 315-14-4 FEED ` 2243-62-1 FEED
49-25-8 FEED
72-54-8 FEED
72-55-9 FEED 50-29-3 FEED
95-06-7 FEED 6369-59-1 FEED
95-74-9 FEED I6787-9 FEED
103-S5-5 FEED
MR
MR
MR MR MR MR MR MR MR MR MR MR MR MR
M R MR 11 R MR MR MR MR MR MR
to to on
n
o
PAGE 06
IBLE-V. DIOASSAY TESTING HAS DEGUN BUT NO DATA ARE AVAILABLE
NCI ft CHEMICAL NAME
C33838
C ') 0 1 4 6
C*>0124 C75414 C >0077
0 0099 C.505S3 C = 4 035 C -2722
C34977 C33929 C53907 CO 393 5
C50317 CJ0533
CO A 5^+6 C50226 C50442
ORANGE G
4*4'-OXYDIANILINE PltEHOL PHENYLBUTAZONE PROPYLENE PROPYLENE OXIDE
PROPYL GALLATE RANDOX STANNOUS CHLORIDE STYRENE OXIDE SUDAN 1 SUN YELLOW FCF
TELONETOLUEHE-2,6-DIAMINE DIHYDROCHLORIDE TOLUENE 2# 4-DIISOCYANATE TRICHLOROETHYLENE ZEARALENONE ZIRAM
CAS fl
ROUTE
1936-15-8 FEED 10 1-80-4 FEED
10.8-95-2 I Nil A L HATER
115-07-1 IMHAl 75-56-9 INIIAL 121-79-9 FEED
93-7 1-0 FEED 7772-99-8 FEED
96-09-3 GAV 842-07-9 FEED 2783-94-0 FEED
542-75-6 GAV FEED
584-84-9 GAV 79-01-6 GAV
7645-23-0 FEED 137-30-4 FEED
SPECIES
M ri R H MR M ; R MR MR MR MR fl ' R MR M MR MR fl R M MR MR
n i?&\ <_n
PAGE 13
I.
i
see
\DLE VI. CHEMICALS THAT HAVE BEEN TENTATIVELY SELECTED FOR TESTING*
tn i w to
mn
NU Ii CHEMICAL NAME
C3691 1 ACID ORANGE (13
C502I5 ACRYLONITRILE
C 5^717 ALLYL ISOVALERATE
C *5453 1-AMIMO-2-, 6-DIBROMOANTHRAQUINOHE
C357 10 AMPHETAMINE
C >0 17 9 AMYL NITRITE
C'35152 ANTIMONY OXIDE
C -5276 BENZENE
C'ASOO BENZYL ACETATE
C*J6 til BENZYL ALCOHOL
C55516 2.2-BIS(BR0M0ETHYL)"13-PROPANEDIOL
C96 159 N# #H1-DIS(2-HYDROXYETHYL)-N-METHYL-2-NITRO-P-PHENYLEHEDI
C36615 BLUE 153
C55692 BROMOBEHZENE
C55243 BROMODICHLOROMETHAHE
C5 5 130 BROMOFORM
C50522 t,3-BUTADIENE# 2-CHL0R0-
C55667 2-BUTAHONE PEROXIDE
C55367 T-BUTYL ALCOHOL
CSS 163 CASTOR OIL
C*5072 CHLORENDIC ACID
C35756 CHLORINATED TRISODIUM PHOSPHATE
C55107 CHLOROACETOPHENOHE CCN)
C55709 CHLOROANPHENICOL'
C55118 CHLCROBENZALMALONONITRILE AND HEXAMETHYLDISILIZANE <C$2>
C -6586 CHLOROBENZENE C .*3254 CHLORODIBROMOMGTHANE
C -6320 3-CHL0R0-2-METHYLPR0PENE
C .3563 CIILORUMAX 60
C -3587 CNLOROUAX 500C
C.;5265 CHLORPHENIRAMINE MALEATE
CHLORPROMAZINE
C:53 12 COCONUT OIL ACID DIETHANOLAMINE
C.`i0737 CYTEMBENA
C55287 DECABROMODIPHEHYL OXIDE
C130I68 DEODORIZED WINTERIZED COTTONSEED OIL
c:*47 95 DFM
C135636 2,3-DIBR0M0- 1-PROPANOL
C56966 O-DICHLOROBENZENE
C56955 P-DICHLOROBENZENE
C507.pfar DICHLORODIMETHYLSILANE
!
C55365 214-DICHLOROPNEMOL
C55161 1,2-DICHL0R0PR0PANE
C135176 DIETHANOLAMINE
C00271 DIETHYLNITROSAMINE .
C56966 DIGLYCIDYLRESORCINOL ETHER
C55129 N/N-DIMETHYLDODECYLAMINE OXIDE
PAGE 16
CAS
107-13-1 2835-39-6
ROUTE FEED GAV
SPECIES
1 10-66-3
1309-66-6
7 1-63-2 160-11-6
GAV
GAV OAV
576-93-6
75-27-6 75-25-2 126-99-8
75-65-0 8001-79-6
115-28-6
532-27-6
FEED
OAV GAV
WATER FEED
108-90-7 126-68-1 563-67-3 51990-12-6 56509-66-9 1 13-92-8
2126-70-7 1163-19-5
GAV GAV
FEED
SP IP/IT
95-30-1 106-66-7 '75^78-5 120-83-2 78-87-5 11 1-62-2 55-18-5
1663-20-5
GAV GAV
FEED GAV WATER
H
i irimwar
t
.'ABLE VI. . CHEMICALS THAT HAVE BEEN TENTATIVELY SELECTED FOR STING*
fn
/
Mm On O
NCI ft CHEMICAL NAME
CIS-OICHLORODIAMINE PLATINUM CII)
054773 DIHETHYLIIYDRUGEHPMOSPHITE
. C54762 DIMETHYL METHYLPHOSPHONATE
C54740 DIMETHYIMORPHOLINOPHOSPHOHATE
054819 DIMETHYLVINYLCHLORIDE
054900 DISPERSE BLUE #1
054873 DODECYL ALCOHOL/ ETHOXYLATED
' 055652 -EPHEBRINE
C07001 ALFHA-EPICHLOROHYDRIN
C55663 EPINEPHRINE
C55527 1 / 2-EPOXYBUTAflE
C55538 1/2-EROXYUEXADECANE
055674 ERYTHROMYCIN
C00522 ETHANE/ 1,2-DIDROMO-
C062 13 ETHYL BROMIDE
C50066 ETHYLENE
050135 ETHYLENE CHLOROHYDRIH
054353 ETHYLENE GLYCOL MONOETHYL ETHER
050083 ETHYLENE OXIDE
054706 FLUORESCEIN/ DISODIUM SALT
0027.99 FORMALDEHYDE
C54728 GERAHYL ACETATE
055185 GILSOHITE
055425 GLUTARALDEHYDE
55549 GLYCIDOL
54397 HC BLUE ft2
>54922 HC RED 83
055607 HEXACHLOROCYCLOPENTADIENE
HEXYLRESORCINOL
055293 8-HYDORXYQUIMjOLIHE ( 55613 ISOPHOROHE
-
t. 55630 ISOPROTERENOL HCL
C55323 LAURIC ACID DIETHANOLAMINE
055572 D-LIHQNENE
054648 LITHOL RUBIHE
054660 MALEIC HYDRA2IDE DIETHANOLAMINE SALT
054842 MALONALDEHYDE
055685 ALPIIA-METHYL BEH2YL ALCOHOL
(.00726 20-METHYLCIIOLANTHRENE
0557,METHYL-DOPA
- I-
C55594* METHYL CARBAMATE
C55629 METHYL CHLORIDE
C50 102 METHYLEHE CHLORIDE
C55550 METMAPYRILEHE
C54626 MOLYBDATE ORANGE
002646 MOHUROM
002164 MORPHOLINE/ 4-NITROSO-
C02915 2-NAPHTHYLAMINE/ M-PHENYL-
C54784 NAVY FUELS JP-5 (PETROLEUM DERIVED)
PAGE
15
CAS ft
ROUTE SPECIES
513-37-1 2475-45-8
106-89-8
GAV GAV GAV GAV FEED FEED
IHHAL
H
M
106-93-4
74-85-l 107-07-3
110-80-5 75-21-8
518-47-8
50-00-0
105-87-3 12002-43-6
SP
WATER
INHAL WATER
INHAL
GAV SP
R M M
R R
FEED FEED
148-24-3 FEED
120-40-1 SP
528 1-04-9 5716-15-4 WATER
542-78-9 GAV
5j6-49-5
R
75-09-2
12213-61-5 150-68-5 59-89-2 135-88-6
INHAL
FEED FEED
FEED SPIG
M
R
DIE VI. CHEMICALS THAT HAVE BEEN TENTATIVELY SELECTED FOR TESTINGS
l N CO OO
mn
N/
hoi n CHEMICAL NAME
C J 5 0 4 9 NAVY FUELS JP-5 (SHALE OIL DERIVED)
CO0306 NITROGEN DIOXIDE
CV5050 H-MITROSODIHETHYLAMINE
C. 3583 H-NITR0S0DIETHANOLAMINE
c ;o ISO NITROUS ACID* ETHYL ESTER
C ;20S4 NITROUS ACID* SODIUM SALT
C:;43G0 NON-DEODORIZED WINTERIZED COTTONSEED OIL
C 5334 OLEIC ACID DIETHANOLAMINE
C -5469 CRG/HIDIH
C55209 OXALIC ACID
C9C935 PARAFFIN OIL
C54933 PGNTACHLOROPHENOL
C35743 PENTACRITHRITOL TETRANITRATE
C5564 1 PHENOLEPIIRINE HCL
PHENYTOIN SODIUM
CD4637 PIITHALOCYAHINE GREEN
PICLORAM
C553Q1 PYRIDINE
C50339 RAUWOLFIA SERPENTINA
C5A 7 39 P-ROSANILINE
c::-521 o ROTENOHE
C130366 SIMETHICONE
035505 SODIUM ALUMINOSILICATE
C55732 SODIUM DICHLOROISOCYANURATE
C`019 1 SODIUM DODECYl SULFATE
C >0204 S0D1UN(2-ETHYLHEXYL)ALCOHOL SULFATE
C; 522 1 SODIUM FLUORIDE
C.-5696 SUCCINIC ANHYDRIDE
C: 556 1 TETRACYCLINE HYDROCHLORIDE
0:4988 TETRAETHYL LEAD
c: 506 1 TMPC
c: 5050 THFS
C!,4831 TRICHLORFON
C (; 4 54 6 TRICHLOROETHYLENE
C34751 TRXSC2-ETHYLHEXYDPH0SPHATE C03327 UREA* l-(HEXAHYDR0-1H-AZEPIN-1-YL)-3~CP-T0LYLSULFQNYD-
C50373 VII1YLBR0MIDE
C54999 VINYLCYCLOHEXENE
C54659 VIOLET 3
C5547 (L WOLLASTONITE
, i,
C5523P XYLENES
CHEMICALS .ADDED TO TABLE VI SINCE LAST ISSUE .
PAGE 16
CAS ft
ROUTE
10102-44-0 62-75-9
109-95-5 7632-00-0
144-62-7 SO 12-95-1
87-86-5
SP FEED FEED
1328-53-6
110-86-1 8063-17-0
569-6 1-9 83-79-4
8050-81-5
GAV
FEED FEED
151-2 1-3 FEED 126-92-1 FEED 768 1-49-4 WATER
78-00-2 124-64-1
52-68-6 79-01-6 ' 78-42-2 1 156-19-0 593-60-2
a
1 i 1330-20-7
GAV FEED FEED FEED GAV GAV
INHAL GAV FEED
GAV
I
see -2 0 1 8
ABIE II. BIOASSAY COMPLETE -- REPORTS HAVE BEEN DRAFTED IXB REPORTS IH REVIEW
NCI R
f 02103 <01976 (0S640 (0 1821 f 037^7
<93750 C02120 C01912 C0213I C03043 C04591 C00486 C03009 CO0157 C02175
C.04637 C03849
C03010 C03792 002084
C 04 126 C 00226 .( 03963 C 33930 C 00586 CO 1610 C 0221 1 C 50022 C04240 CO 184 3 C 32 153 C00259 C02I19 C0 38 16 C02073 C02186
CHEMICAL NAME
ACETAMIDE P-ACETOPHENETIDE, S'-NITROALOICARB ANILINE, IMI-DIMETHYL-P-HITROSOO-ANISIDIHE HYDROCHLORIDE
*-AlISIDINE HYDROCHLORIDE L-ARGIIIIHE GLUTAMATE BENZIMIDAZOLE, 6-NITRON-BUTYLUREA CARBAZ-OLE, 3-AMINO-9-ETHYLCARBON DISULFIDE DICOFOL 2,5-DITHIOBIUREA ENDRIII ISOCYANIC ACID, 3,3,-DIMETHOXY-A,4'-B2PHENYLENE ESTER
METHANE, TRICHLOROFLUOROI1ETHI0DAL SODIUM
METHYL ORANGE B , HITHIAZIDE NITROUS ACID, SODIUM SALT
2-OXSTAHONE, 3,3-DIMETHYLPARATHION PHENOL,4-AMIN0-2-NITR0P-PHEMYLENE01AMINE, DIHYDROCHLORIDE PH05PHAMID01I PROCARBAZIHE HYDROCHLORIDE STYRENE, BETA-NITROSULFISONAZOLE TITANIUM DIOXIDE O-TOLUIDINE, 5-NITROP-TOLYLUREA TOXAPHENE UREA UREA, 1,3-DIETHYL-2-TH10UREA, (P-ETHOXYPHENYL)UREA, 1,1,3-TRIMETHYL-2-THIQ-
iM. ^
ui
PAGE 07
CAS ft
60-35-5
116-06-3 138-69-6 t34-29-2 20265-97-8 4320-30-3
94-52-0 592-5 1-4 132-32-1
75-15-0 115-32-2 142-46-T
72-20-8 91-93-0 75-69-4 126-31-8 547-58-0 139-94-6 7632-00-0 1955-45-9 56-38-2 119-34-6 624-18-0 1 3 17 1-21-6 366-70-1 102-96-5 127-69-5 13463-67-7 99-55-8 622-5 1-5 8001-35-2 57-13-6 105-55-5 150-69-6 2489t77-2
ROUTE
FEED FEED FEED FEED FEED
FEED FEED
FEED FEED FEED GAV FEED FEED FEED
FEED GAV IP/IJ FEED
FEED FEED GAV FEED
FEED FEED FEED IP/IJ GAV GAV FEED
FEED FEED FEED FEED FEED FEED FEED
SPECIES
MR MR M* R MR MR MR MR MR MR MR MR MR MR MR MR M* R MR MR
MR MR MR MR MR MR MR MR MR MR nR
M .R MR MR MR MR MR MR
see 2019
4*
ADLE II. niOASSAY COMPLETE -- REPORTS HAVE BEEN DRAFTED
tie REPORTS IN REVIEW
NCI ft CHEMICAL NAME
CHEMICALS MOVED FROM TABLE III SINCE LAST 1SSUE
CO 37 7 0 ACETANILIDE# 4 *-CCNLOROACETYL)C02095 ADIPAMIDE C02039 ANILINE/ P-CHLOROC02255 ANILINE/ 2,4-DINETHOXY-, HYDROCHLORIDE CO 1 990 ANILINE/ 4/41-METHYLENEBIS (N /N-DIMETHYL)C02006 BENZOPHENONE, 4,4'-BIS(DIMETHYLAMINO)C03850 P-BEHZOQUINOHE, .DIOXIME C03361 5BETA-CHQLAN-24-0IC ACID/ 3ALPHA-HYDR0XYC03565 C.I. VAT YELLOW 4 C08662 COUMAPHOS C03667 DIBEHZO-P-DIOXIN, 2,7-DICHLOROC03656 DIBENZO-P-DIOXIN C02028 DIDUTYLTIH DIACETATE C50055 DIMETHYL TEREPHTHALATE C02244 DIPHENYLAMINE* 4-NITROSOC02368 ETHANE/ 1,1-DICHL0R0-2,2-BIS(P-ETHYLPHENYL>C02S57 ETHYL TELLURAC ' C03651 FEHTHION C92142 HLXAHAMIDE C32391 LEDATE C03231 H-1-NAPHTHYLETHYLENEDIAMINE DIHYDROCHLORIDE C 0 0420 MITROFEN CO290 4 PHENOL, 2,4,6-TRICHL0R0C0394 1 0-PHENYLEHEDIAMINE, 4-NITROC02222 P-PHENYLENEDIAMINE 2-NITROC0360I PHTHALIC ANHYDRIDE C02313 PIPER01IYL DUTOXIDE C92324 PIPEROHYL SULFOXIDE C30000 MEMTHOL/DL CO3907 PYRIDINE, 2-CCHLOROMETHYL)*-, HYDROCHLORIDE C02200 STYRENE C02051 O-TOLUIDINE/ 5-CHLOROC02335 O-TOLUIDINE HYDROCHLORIDE C03S0&M). UREA, C2-BR0M0-2-ETHYLBUTYRYI)-
f_n
/
PAGE 03
CAS ft
ROUTE SPECIES
140-49-3 623-94-4 106-47-8
101-61-1 90-94-3 105- 11-3
434-13-9 123-66-5 56-72-4 33857-26-0 262-12-4 1067-33-0 120-6 1-6 156-10-5 72-56-0 30145-38-1 55-38-9 623-02-4 19010-66-3 1465-25-4 1836-75-5 88-06-2
99-56-9 5307-14-2
85-44-9 51-03-6 120-62-7 39-78-1
100-42-5 95-79-4
636-21-5 77-65-6
FEED
FEED FEED
FEED FEED FEED FEED GAV
FEED FEED FEED
FEED FEED
FEED FEED FEED
FEED FEED
FEED FEED FEED
FEED FEED FEED FEED FEED FEED FEED FEED GAV GAV FEED FEED FEED
MR
MR MR
MR MR MR HR MR
MR MR MR
MR MR
MR MR MR
II R MR
MR MR MR
MR MR MR MR MR MR MR MR MR MR MR MR MR
. *\
ADI E IIIA. BI0A5SAY HAS DEEM COMPLETED
REPORTS ARE BEIHG DRAFTED
HCI ft CHEMICAL NAME C5Q044 ETHER, BIS<2-CHL0R0-1-METHYLETHYL)
CAS ft 108-60-1
ROUTE SPECIES GAV M
HEMICALS MOVED FROM TABLE TV SINCE LAST ISSUE
C02960 C02299
C92926 C02937 C02880
C02959 C002 15 CC297I C03612
C02835 C02302
C02368
AMMONIUM, (2"CHLOROETHYL)TRIMETHYL-, CHLORIDE ANILINE, 2,A,5-TRIMETHYL-
AZOBENZENE CALCIUM CARBIMIDE DIPHEHYLAMIHE, N-MITROSO-
ETHYL TUADS MALATHION PHOSPHOROTHIOIC ACID, 0,0-DIMETHYL O-CP-NITROPKENYL) PHTHALAI1IDE
SODIUM DIMETHYLDITHIOCARBAMATE TOLUEHE-2,4-DIAMINE
O-TOLUIDINE, 4-CHLORO-, HYDROCHLORIDE
ESTER
999-81-5 137-17-7 103-33-3 156-62-7 86-30-6 14239-68-0
121-75-5 298-00-0
88-96-0
128-04-1 95-80-7
3165-93-3
FEED FEED FEED
FEED FEED
FEED FEED FEED
FEED
FEED FEED FEED
MR MR MR
MR MR
MR MR MR
MR
MR MR MR
PAGE 09
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ABLE HID. BIOASSAY HAS BEEH COMPLETED
KCI ft CHEMICAL NAME POSITIVE CONTROL
C 00384 C 0 3 349 (01456 (01434
(.03452 (01457
CC2700
CO 1423 C 0.14 o 9 C00362 C00373
CO 1490
ACETAMIDE. N-FLU0REN-2-YLACETOHYDROXAMIC ACID. N-FL0URGN-2-YLAFIATOXIH Bt
1 -BUTANOL 4-CBUTYLNITROSAMINO)CARBON TETRACHLORIDE
CYCASIH DIPENTYLAMINE. N-NITROSOGUANIDINE. 1-METHYL-3-NITRO-1-NITROSO
LEAD ACETATE SAFROLC S-TRIA20LE. 3-AMINOURACIL. 2-THI0-
CAS ft
ROUTE SPECIES
53-96-3 53-95-2
1162-65-8 3817-11-6
56-23-5 14901-08-7
13256-06-9 70-25-7
301-Q4-2
94-59-7 61-82-5 141-90-2
FEED FEED
FEED FEED
GAV FEED
FEED FEED
FEED
FEED FEED FEED
M,. R Ru
R R
MR R
R R
R
RM MR R
#
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PAGE 10
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\BIE IV. HISTOPATHOLOGY INCOMPLETE
MCI ft CHEMICAL NAME
C -*1 15 14 C 50 0 1 !
C135 1 0 C13593
06673 C 33703 0 3703 037 14 0 3716
008695 0150259 C 18628 C53838 050124 050124 C90033 C50157 C50033 054545
C53907
ADRIAMYCIN BENZOIN
CIMIAHYL ANTMRAMILATE P-CRESOL, 26-DI-TERT-BUTYL-
DIAZIHOH DIBEHZO-P-DIOXIH, 1,2,3,6,7,8-HEXACHLORO DIBF.NZO-P-DIOXIH, 1,2,3,6,7,3-HEXACHLORO DI B1:NZ0~P-DI0XIM> 2,3,7 3-TETRACHLORObIBiKZO-P-DIOXIH, 2,3,7,8-TETRACHLORO-
FLUOMETUROH HEXAMETHYLMELAMIHE MALATHIOH-O-AHALOG ORANGE'G PHENOL PHENOL 1,2-PROPANEDIOL RE3ERPIHE SELENIUM SULFIDE SELSUN
SUN YELLOW FCF
CHEMICALS MOVED FROM TABLE V SINCE LAST ISSUE
C50282 CJ0646 C 54262
C33894
C 524 59 C54808 C04580
2-BIPHEHYLAMINE CAPROLACTAM 1, 1-DICNLORQETHYLENE
PENTACHLOROETHANE
1 , 1 , 1,2-TETRACHLOROETHANE ASCORBIC ACID ETHYLENE, TETRACHLORO-
` i ,*M Cjl
|. PAGE 11
CAS ft
23214-92-8 119-53-9 87-29-6 123-37-0 333-4 1-5
1746-0 1-6 1746-0 1-6 2 164- 17-2 645-05-6 1634-78-2 1936-15-8
103-95-2 103-95-2 57-55-6 50-55-5 7488-56-4
2783-94-0
ROUTE
IP/IJ FEED FEED FEED FEED SP GAV SP GAV FEED 1P/IJ FEED FEED WATER WATER SP FEED GAV SP FEED
SPECIES
HR MR MR MR M R M MR M MR M MR MR R M R MR MR MR M R
90-4 1-5 105-60-2
75-35-4 76-01-7
50-81-7 127-18-4
FEED FEED GAV
GAV
GAV FEED
INHAL
M M M R R
H
R R R
M ;R
I
fABLC V DIOASSAY TESTING MAS BEGUN BUT MO DATA ARE AVAUADU
MCI fl CHEMICAL MAME
C00732 AEROZINE 50
C50A75 AGAR AGAR
CQ8899 AGARITIHE
C5CA6A ALLYL ISOTHIOCYANATE
C50613 AMINO UHDECAHOIC ACID
C06360 BENZYL CHLORIDE
C50635 8ISPHEN0L A
C50602 1 # 3-BUTADIENE
05A375 BUTYL BENZYL PHTHALATE
C53&A 9 CAkNUISINE
CCC639 GAMMA-CHLORDANE
CO687 1 CHLORDANE, ALPHA ISOMER
C5378 1 C.I. ,DISPERSE YELLOW 3
C55005 CYCLOHEXANONE
C53792 D AND C RED HO. 9
C50657 DIALLYPHTHALATE
C50260 1 # 6-DIAMINO-2# 6-DICHLOROBENZENE
C5 1581 CIS-1#2-DICIILORO ETHYLENE
:5A591 TRANS-1# 2-DICHLOROETHYLENE
C 5 6 3 8 6 DI (2-ETHYLHEXYL ) ADIPATE
C52733 DKZ-ETHYLItEXYL) PHTHALATE
C50660 A# A'-DIPHEHYLMETHANE DIISOCYANATE
CQ0522 ETHANE, 1,2-DIDROMO-
C0A626 ETHANE# 1, 1# 1-TRICHLORO-
'50334 ETHYL ACRYLATE
50135 ETHYLENE CHLOROHYDRIN
:50A53 EUGENOL
:50395 GUAR GUM
:507A3 GUM ARABIC
',54364 GUM TARA
;06593 HEPTACH LOR EPOXIDE .
:50A19 LOCUST BEAN GUM
050362 MANNITOL
050715 MELAMINE
009018 METHAPYRILENE
C5A60A A,A'-METHYLENEDIANILINE 2HCL
C50102 METHYLENE CHLORIDE
C50680 METHYL METHACRYLATE
C06A28 MIREX
C08902 NITROFURANTOIN
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PAGE 12
A
CAS fl
ROUTE
57-1A-7 9002-18-0 2757-90-6
57-06-7 27323-A7-3
100-AA-7 80-05-7 106-99-0 85-68-7 3567-69-9 12789-03-6 5 103-7 1-9 2832-A0-8 1 08-9A- t 5160-02-1 13 1-17-9
156-59-2
103-23-1 1 17-81-7 101-68-8 106-93-A
71-55-6 1A0-88-5 107-07-3
97-53-0 9000-30-0 9000-0 1-5
1 02A-57-3 9000-A0-2
69-65-8 108-78-1
9 1-80-5 10 1-77-9 75-09-2 80-62-6 2385-85-5
67-20-9
IHIIA L
PEED
WATER GAV
FEED IP/IJ
FEED INHAL
FEED FEED FEED
FEED FEED
WATER FEED GAV
FEED GAV GAV
FEED
FEED GAV INHAL GAV GAV
5P FEED
FEED FEED
FEED FEED
FEED FEED FEED
FEED FEED
GAV
INHAL FEED FEED
SPECIES
M MR
MR MR MR M MR MR MR M MR MR MR MR MR MR MR MR MR MR MR MR MR MR MR
M MR MR MR R MR MR MR MR MR MR
M Ri MR MR M R: