Document pBaMZryLOzMnE7VX2GnGd4OYE

i LF TTEECCHHNNIICCAALL RREEPPOORRTT SSUUMMMMAARRYY 70: TECHNICAL COMMUNICATIONS CENTER -- 20120 TO: TECHNICAL COMMUNICATIONS CENTER -- 201-2CN foiosten 2, 1070 arch 23, 1979 Umporea-- epre isprintedanboth sites ofpp, ndtw copes 0 TCC) (Important -- If report is printed on bo~h sides ofpaper, send two copies to TCC.) Environmee ntal Labor ratory (e EE & PC) Environmental Laboratory (F,~. ~ PC) or 0535 l~)t. Number 0535 ~roject "FFaattee ooff FFlluuoorroocchheemmiiccaallss J itti\p Ffeport Title Final Comprehensive Report: FC 143 Final Comprehensive Report: To R. 4. Prokop R, ~, Prokop PT A. N. Welter FC 143 oject Number 9997700661122664433 nn aport Number frg az012 Emp 09362 Ioyee Number(I) 09362 Notebook F~efererme -- SECURITY~I~ se eereCO[ceooinrovBenonorton KEYWORDS: [] Open (Company Confidential) I~] Closed ISf)eciel Authorization) CURRENT OBJECTIVE: | "AGRE 3M CHEMICAL REGISTRY NO. of Pagel Including COVerlheet 1111 Yoroo g New Chemicals Reported In Suv. 4Select terms from 3M Thesaurus. Suggest other applicable terms. ) FEEEEl&RuPoPCCroc--heD Diniviv.c. al ((AAqmuaattyitci)cal) Fluorochemical (Analytical) ((((A D sDoeqeiggulrra)aatdidacat)tiioonn)) T(osxoiicl)ity Toxicity the period; 1977-1979. FPiinnaall RReeppoorrtt:: E Ennccoommppaasssseess aallll wwoorrkk ppeerrffoorrmmeedd dduurriinngg the period; 1977-1979. |yeronAr ABSTAAACTY. (R0a7a50mworshnhsSmrc ications ved by TeSommer Se REPORT ABSTRACT: 120~250 words) This abstract informiltion is distributed by the Technical Communications Center to alert 3M'ers to Company R&D, It is Company confidential material. ce: D RDI..LLL... BB Boaahccaoonnn R..LPo. thBaophroangada Y.Pothapragada FET I~formation Liaison fcoru s-- 3M CONFIDENTIAL tr oc 22556699..00000011 2569 EExxhhiibbiitt 2569 State of Minnesota v. 3M Co., Court File No. 27-CV-10-28862 M3MA0AI04141100331166 IINNTTRROODDUUCCTTIIOONN oTTnhhee frrlaauttoiirooonncaahleleemicffaoolrrsppeherarfsfoorrbmmeeiinnnggdieesnncvvuiisrrsooenndmmeennpttraaellvioeeuffsffeleycct~g2pgttuuddiieess on fluorochemicals has been discussed previously" TTsisnhuuhererftfaahssceuuctbtbaaejjnnenetcvct,ti,trow wffnlhlhumiuioeccornhhrotocchhhhaaaesessm mitttihchhcaeiealsl ppmooooatfftteeenttnrhthtiiiiiasasalll rreefifoppsoorrorurtsw wteiiddiidsesesbspyFpFrCCreetaah11dde4433,Tdd, eiifssaalttroraaininnb(biiuRouo)ttnniiiiococnn cccinhooeaamttthiiinecngaglelniinyvnddiruuiosssnttm rrtyyhe,,entabbmooamtsthohnthidduoiosmmmesm setasalitittcceaarlolifllayylpeaaisnnrddfluusiineondrtteoer-rbnyonacatttthiiaooennnoaiTalclellfyyla.o.cnid(R.FFCC) 114433 chemically is the ammonium salt of perfluoro-octanoic acid. wTTehhiiigsshtm maaotfeterri4ia3al1l weight of 431 aiisnsd aatwhwehhiitcteehemggirrcaaannluullasartrruppcootw wuddreeerr and the chemical structure shhshhaaoovvwwiinnnnggbbeeaalloom mw wo.ol. leeccuullaarr Cy Fy COON, C7 FI5 C0O-NH4 FFCC 114433 sooTTfohfhriispw wstaaitrrtoeeeenrpproorassrtonotldluccuboaobinqnilsulsiaoiotttlyyliii,c,ddaatpptteeaoassrxrittciiaatitllitilloyon.naavvcacaToioihelleaefaffbbfiplliecrecioieebiinnanntbfftoslso,re,rmmdeadaentetgivigoroirnanradodaniiatnmntieioonttnhtnh,aee,l ssaaoorrrieieilasalkss of FC 143 is sorption and of FC 143 is ddaeqeffuiiannteeiddc.. toxicity. The probable environmental risk MMEETTHHOODDSS JhWaaavtteeerrbesseoonlluubtbihileliittsy yu,b, jebbciitooddeoefggrratadedacathtniioioncnalaannddrepssoooiriltls~ gorr~gsiio. onn mmeetthhooddoolloogyg''yss have been the subject of technical reports~-- ;. A) A) AAqquuaattiicc TTooxxiicciittyy TTeessttiinngg TTahfheteertteessttthiaintnggdpepsrrcoorttoiobcceoodllssbyu uttiUillSiEizPzeAedd (f1fo9o7rr5)ttCp~ 1j)s, ssttuuddyy wweerree m mooddeelleedd after that described by USEPA (1975)~ ". 11.. BBlluueeggililll SSuunnffiisshh TsTsfthtihueusedhdyybbwllew uwureeeergergeieilhllooelblbtdsstaauuiininnnnffeeiidsdsfhhibffrer((oroLLmgmeelppaoaoasmmsiippssrrihivmmvoaaaalcctdterreioon~cghhhhaaiitttrrcacuunhhsskee))srryyuuf,i.assieelddleSSdtiitnooncwckiktththhiiss AwcAcfiaiastdrdrhhabbaioiolnlw anyy-e-f3rfipep0ilh-hlttonhoeeitetrrnooledeuppdtdeeerirniw wiooetedldrfllailbnoofsew wfiaratgt]1t.ie66leoarrnshhsmm oopuauaerihrirsnsonitltodaalldiiiiig,nnngeghhedtdwtatasaaaannnttkddmas11i8844n-f-1t1hhil55aooliuueCCnrrd,ses. ddw daairrtkhk,, w ttfhhiirsrtohhouuggwahheoro3ueu0tt-m fttehihdneeuTteeaatccrctcarll-aiiMm nmiansatittiiiooonndnaiaalnnpydde,rittoefedsosto,tidinnwgghaesippenm ergraiiooiwnddit.t.ahinheeTTdlhhdee 44wf88eisrhehhoow uaurcrescsrleippmrfreaiidotoerrdTtteooftroaraa-nnMdd14intthdhraroyodusuaggihhplyooru,iutotrfotthohtedeo ttbteeeesssintttignppgew e.rriiitoohddh..eldFFiisshh were acclimated for 14 days prior to testing. AwAcecuruteteepessrhhfooorrrtt-m-tetederrmmon ((9F9C66--hh14oo3uu,rr)) losstttaat3tii4c0c. aaqqCuuaaarttibiccon-bbfiioiolaatsssesarayeydss ow wAw Afleelelllrllwelaggtww plleaaaeartssrtfesseororrraamoqoqfweufudaaartkkriennoiaoraon,ww, nnpFCl33u55ccsoo1xmxm 4Fp3pCo~2, os00is1liotx4xti3itoo~7nn00c3o4mwwoa0mmpa.a,rss, isuC uccessooadeennrddttbaaaoaiainnssnsiti-nufnttghidghlyeete11r66cddehiidallllumuiitbeeteenenrtrrt..ss. of water or water plus FC 143 comprised a study chamber. b"a`D DCaaollmeemeFF racatitattliigg FFiisshh fish FFaarrm m,, food of B Brraaddyy,, known bcommercial fish food of known N Neebbrraasskkaa ccoommpposoistitiioonn.. 22556699..00000022 33MMAAO011441100331177 . 2. - 2- TTswiwzeeennttyyandbblluuweeeigggiihlltll, size and weight, sswwuueennrffriieesshhtt,,eesstt((eeLLddeeppoaoattmmiisseeaamcmchhaaccrrccooooccnnhhcciieerrnnuuttssrr))aa,,ttiioouunnnniiffooffoorrmmFFCC iinn114433.. TwTeieststhtinffiiss3hh0 wmwieenrreueterrsaannddfooommllllyyowiaagssgssiiggFnCneedd143ttooadvvdaairrtiiiooouunss. tteessTttestcchhaatmmebbmeeprressratures wwowxeeiyrtrgeheeinnmmaaiil3nne0vtteaamliii,nnneeuddtaensdaatt oxygen level, and pfH11o89lo~f-wia11~lClgC.. pH of all FttCeessMMttoo1rr4tt3ssaaoollllaiiuudttttdyyiii,,otoinnossttnee.mwmwpepeererrreeTaaettmmsuuteerraaeesst,,uuerrmeeddpddiiesrssasaattotolulvrveeedsd G22e44n--ehhrooauulrr General ooiibbnnsstteeeerrrrvvvvaaaaltltssiioonnoossrr ururnneettlliiaallttiivvtteeoottaattlloo mbmbeoeohrhraattvvaaiillooiirrttaayyll hhaooadrdr oeoeccrrccrruuaarrttrriieeccdd..sswwiimmmmiinngg pupusasaetetddtteerriinnnnss ttwhwhieiessrreessttssuuiiddmmyyiillawawrerelrlryeye ccrrooeennccssooiirrddddeeeedrrdeeddwwhheettnnoo babaeepppprrggooeeppnnrreeiirraaaattlleell..yy hhOOeerraaggllaattnnhhiiyyssmmss aanndd ffrreeee ooff ddiisseeaassee.. 2. Aquatic Aquatic Invertebrates Invertebrates - - 4488 hhoouurr Static Static LLCCg5,0 DwDaeaprphhenni~eaaxpmmoaasggenndaa,,tottFwweCenntt1yy43,oorrgglaaotnniiss3mm4ss0 were exposed to FC 143, lot 340 ppaatteerrvvaattrreeyysstiitnnggcchhaaccmmoobbnneeccrree,,nnttrraattiioonnss fifinnoorrccaa448rr8bboohhnnoou-u-rrffssii..lltteerrFFeeiiddrrsstwtweelliillnnsswwttaaaattrreessrr,,wweerwrweeiitthhccoouuccnnhhtteeeemmddiiccaaaallnnddaadpdpdldleaeadcdceedd maaanngddnass.oolluubbiilliizzeedd pprriioorr ttoo tthhee aaddddiittiioonn ooff tthhee DDa~pphhnn{iaa 55II66nnvvmmeeggrr//ttlleebbwrwrhahatiiteelleetteevvsesetrrttteeccbboorrnnaacctteeeenntttrtreaeassttttiiooncncsosonncw cweeeennrrtteerraa77tt..55ii,oo, nnss1100,ww, eerr11ee88,, 750, 1000, and 1350 mg/1. 3322 442200,, aanndd 556600,, 750, I000, and 1350 mg/l. LtCnhC8g~~%,0UUSSvvEEaaPPllAAuueess((DDwwuuiillttuuhhtthh))9955PP%%rrooccbbooiinnttffiiddcceeoonnmmccppeeuutteellrriimmppiitrrtssooggwwrreeaarrmmeeoonnccaaltlthchceeuullaaSSttMMeeddTTrraauuccssiinngg ssyysstteemm,. RREESSUULLTTSS TowToaababbttbtlealaereiinnees11 ddollluuiuibssssltitiesnsn,ggwwaaFF>tCtC2ee0rr11g44/33ss,1,oo.lluullbboottiiFllCii334tt4100yy4..3 aawnnhddTTehhriippsseaarrmtmataiaditttdteieeirrodoiinnaatlloccooweieisasfftffeiioerccxxiitteearrnnpoettpmmeeeallddryyaaettdaa watatooabbsstooeffrrroobbrreemmsddo..laaubggleeTTellhh,iissaall>mttm2a0hahtotoeeuugrr/ggliihh.aallffuurFiirsstCthheess1rrl4l3liggaabhwddtthddlleiiyyrtteiioollnniaisspdpdoooeoppffdhhiilFlFtiCiCoccw11a4a4as3ts3erwweeeevvrriiaeeddpeepnnessccaiieermmddeiidllaarrllyy bbbeyy caaonppcaalrruttdiiettdiioonnthacctooeeffFffCiicc1ii4ee3nnttwouooflfd55..notBBabassieeoddcggoonngenttthheresaseeteddtaaottaaaniitt apccapannreciable eeabeenexxmmdttppeeiicnnrroittiitnscccaaliillnunbdieotrtrdhhceeeeollnaatcttheeeiainntnovovtniinrrsrsFoaohChnntiimmipp1eeo4nnn3bbttee..ttwfwwoaeeuceetlCConndhhrii.ootntuuohhteee-eIttw~nbaaittataolee`hlc)rre-~ierss"noollhshtyuuaarsbvbvateiietellemii~d,tteeyysstocctrroohffieiabnbeaeaaddsacccprhhapannieerbmmeeiicdcciaaallble WWeeahhnrreedrrnnoorriatasppiispspllbyyciciiooonnncnggsosinidcdddeeaeatrtnraaetedrdaggteettinnoooeenrrbbaaeettfeeaaaddcpptpporffrroooo.rrxxiimFmFCaCaIttnee11ll44tyy33heitootroonneetsthyoohisrritsdsdeeemrrpp,rroooopffptoohsesmmeaeadgdgannsiicrrttreeuuillddbaaeetet..idioonnsshhiipp,, tftfhahaiiccssttoorrmmaattoofeferriiaaaappllpprrowowxoxoiuiumllmaddatteebblleeyypprrI10o0o..jjeecctteedd ttoo ppoosssseessss aa bbliooecoonmcceennttrraattiioonn TTAABBLLEE I1 PPaarraammeetteerr WWaatteerr SSoolluubbiilliittyy aanndd PPaarrttiittiioonn CCooeeffffiicciieenntt ooff FFCC 114433 TTeesstt RReessuullttss SSoolluubbiilliittyy PPaarrttiittiioonn CCooeeffffiicciieenntt CCooaarrssee mmeetthhoodd nn--ooccttaannooll//wwaatteerr >2200 gg//1l 5 5 a~s _go~b 22556699..00000033 I3MMAA0011441100331188. Sa- - 3- FuSFUCCnhndadeke11rer4433ct`twwuhhaealestsuttereffaseoott.uubnniddccooodnnttedoodsiirttbbaeiiedoounncctssooimmoeppenmllmpeepttllseeotolluyyydyeeydd"yFug~tg"i.iis1). latitazaTTnenhhtdtee mtt22ooi/c11r7b/bo22iibooiddmmaeeoolgngnrtrtahahtddeasatttiioonn cstEtShyuhhUeaelaTttktCoueiChnrhra.eeecmsmnuoolllDtddiuueettrrrreeieii,,nvvgeebdDdlDeoetcdchffaeaerrtvgoouurmmtrraidmaaeaaccatnnttlddiicovvonaauTTttwereeiissdndnetudCoCssfyiillttuuiidduteeggthsseeiisliMMiizesennetttoodurrccdoouuyllmaaiPPcllaraaoononbbsbtttiwwaaraaaiialssinntnteeededtoefsttfftrrrreeooaammttmmeenntt TPmtsThhiyoSsiircrtsrnoeoenmbmmxe.eaatsstteeenrdrwDwieihhuadaiirllccihhnpgwweoorccuuiootlluouhddldledsdbbteeddioefemgegeerrtxxaaipcpddmeoeeeecuctrteseFFudedCCnalott11foto4433erppteeehaddrriiiassdaiibssynsnttootttumdiiiycdndnerevvoatteebhhllieesooatpplree,sannivvcniaihhrtreeoaonnobnnfccomemeleeinnsttm. fa((SSodrro0rsaa1ionn1lerggxsbessteooed22rrn--ppd77ttte8%oiid))oo.,bnnpreioossrlffttiyuuo`tdddtshiihseaeeenssodFFfyCChhaat1l1vvi44oeem33aensspphhurrsooneeowwaissnnlleetnnttett(hhrTaaeaittidnnblaabe4appyppw3rrma)ooaip(xxc%gii~r)smmo.aabssttiooeeaClllllouuyynttcvii5aeoo%trnn,asbewwolaalyssi,sm. d5asaa(T0edoppa7sbpspi11corlr0r7oro3biWw xx)eboiiodm eumudlaladdtttoebeylbblyy"oeBHMra8d8dol0meel0b%asslikooeorlorsbrafbfin(eectdddtt6oyhyhseeaawFclfohCtaataeem emmrror1oeu4ubn3tstnhythotwrrieaeoaolesefdfs(oTFcF((Cra3C3alp))bct11luied44dio33eesns2scoaa)oercdddrp.ospstoeotiifrur.obsobfinneeinddcCgitt.orerttnoiniotavathelslettsrhshsisaiessrcleyne, me converted (Table 2). described btyo a constant, Mobilityt~~ Hamaker" " Kou: which reflects the organi FC 143 was calculated using the whereby adsorption coefficients c scheme are cccooonnntvteeennrtttedooff to a tthhee constant, K , which reflects ssooiill.. TThhiiss"Ciinnvveessttiiggaattoorr has the organic sshhoowwnn tthhaatt tthhee relative nobility of a group of pesticides could be determined relative mobility of a group of pesticides could be determined vIinthThipsesftaischiidoenmtonbdiltihteyt th`Ien aKBBiy"vianlguethciosuldteebse, cFoCrre1l43atehdat in this fashion and that the K value could be correlated with pesticide mobility. In a~lying this test, FC 143 had 3 Ko "Value of 17, being slightly less mobile than chloramben, a K value of 17, being slightly less mobile than chloramben, Wkfak0e962r'1s278w,ork"wpich wae the mo-- st mobile pesticide based on K o~f 12-8, which was the most mobile pesticide based on H~aker's work(). Table 2 Table 2 SSooiill SSoorrppttiioonn TTeessttss oonn FFCC 114433 Parameter Test Solution Results Soi) Sorption Parameter Soil Sorption AdsoTrepstt ion Vater Solution ~ 5%, range Results2-78 DAedssoorrppttiioonn W Wataeterr ~ 5%, range 2-7% 80% of amount adsorbed %,.Desorptlon Water 180% of amount adsorbed K oc 17 RNR 33)e)oe"s.ssuul,ltBBtssaa"ssFeeooEddff 1oo4ttnhn3h'eewtthohaaeueccluudtaateeqqubuasesattttiaacicctotiinccsttoiodxaxaeiqqircucueiaiadttttyyiiccprccarttrecieitttsseiettscsrraiiaalaalrryeesessnttttaaaoabbbnnuul-lillstiaahgstteeineddcsd bbt((yTyoTaabbllee tTNtitihshh=IiOeoe"ssSttoeHvvoci,ebdborreaerFttCetrcabebnnrloor1aatoa4tetteb3tdeeditssoawinttohnhaaueanahnldtddadtswbttiihnhbheneeeevvneceeniirornLnttneoevveshnbbeeidetrrrreiateatertnerteevegbbdessrrdaafthurpteeeesrreeseaddnpddceaatwtaiiitnciaatnreaedctctlhllohoyyrviirtsrisrogeneelottlofaeaenststseg-etttp"1?0%t:ew w~)ce"e:ici.lollst.oww `ITittitthh those data obtained when testing fresh warm w~e~o~pecies. WTEaBaonngihrddggie--sf1ttrruhhcyyeenoiidrrressrrttetuurTlaaddeekiistoieeeuuonsslinttsswwtoeehrrccaeeaoossmmscppbceorroesniiensntsstreeraatoscThTbttaeaseenbeddilerveefessfttdeooc44tBEreaaGGnnp&oMfddGeaF5BP5t..Ceiidoonn1lyooT4Tm3mh"hiieecscsa-setse ". sLsLsutatabububldodoeiirrtoeaahssttaoolrryy Teve1son hatcnani1ity, survival, weight snd length changes were undertaken to assess the effect of FC 143 at sublethal levels on hatchability, survival, weight and length changes Young ((TTaabbllee young stages 44)).. stages ofIItt of aniiss an aquaSo Species are ggeenneerraallllyy aacccceepptteedd aqua~aspecies are Gwite sensitive tthhaatt tthhee iimmmmaattuurree quite sensitive indicators oorr indcators 22556699..00000044 awaota10sto 3MA01410319 . Cal 4 - T Taabbllee 33 FFCC 114433,, RReessuullttss ooff TToesstt O Orrggaanniissmmss Bluegill Sunfish Bluegill Sunfish DDaapphhnniiaa m maaggnnaa 9m6 gH H/rr1,,.L"iCFCse0 mg/1 569 569 6363? 632 632 9966 HHoouurr A Accuuttee SSttaattiicc TTeessttiinngg LLiinmiittss LLoowweerr,, m mgg//l1 U Uppppeerr mmgg//l1 500 636 500 636 570 690 570 6~9 570 698 5?0 698 TTaabbllee 44 LPPeeenrrgccteehnnttaaagngdee WEEeggtgg WHHaeatitcgchhh,t, oPPfeerrccFeeantnthtaaeggaeed MSSiuunrrvnvioivwvaalFl,r, yTToottaall cL((PoPeninimcmgeeothpnphtharaaZalneted8sioWnppesrtoommoWefeleZiaFagsCsh))t 1dod43ufu4rriiFnnaggtheEEaxxdppoos}s~uuirnreenowttooFvvryaarryyiinngg ConcentraticoonnceHnattrcahtio%nsSuorfviFvC30a0l1DD4a%3ayyssLePPnoosgsttthHHnaatmtcchhWeight mg mg/1 Concentration Hatch ~ Survival % Length mm Weight mg mg/1 110000 2966 8s 85 20.5 59.5 20. b 59.5 5500 0922.,55 494 2200 62.5 62.5 25 a0 2.5 2 " 1122..55 9900..55 9917..55 21 21 n71 66..22 0914..55 093 721 66qa CCoonnttrrooll 9966..55 0033..55 2200..55 68.5 68.5 "awWoorrkk ppeerrffoorrmmeedd bhyy EEGG&LGG BBiioonnoommilccss LLaabboorraattoorryy,, IInncc.. PbsSSutum .nmmaPararuyyl,ttaabbasl]eepassruutbbmmoifitttteefddinattolo EErennpvvoiirrrtoo.nnmmeennttaall LLaabboorraattoorryy,, 33MX,, St. Paul, as part of final report. ooiffnvccehhsetemimigicacatalillolyyn niinonddusuctceeaddtisttotoixxciicacilitltyyy.. sigIInnniftthiheceanpptaarradam imfeeftteeerrrsesncuuennsddeerr w wi1ne0er0vreeemsgoot/bib1gtt,aaaiitninroeeenddd.u. cntoiAAotstntsatthhteiewsetrhhieiicggahhreleelscsytotrdFsFCeCigdn1144ii3n3ficsccauoonrnnvctcieevndnatiltrfrfaaetptriieeoornnncceenttetsesstteedd,, saa1nun0Odg0gwew mesegiti/gig1hv,htet reo33df00uddacaatiyylossantseppnootswstteornehhsaaetrtetcchch.o.irndeAA tdlhletthhionoduueggvshheulrovtthphivemeessaeneltdpdaoeatfrtaacecnauarmrteeulative wsttoeuorxxgeigicceioisttbtyysi,v,eervttheohedef ddafoaorslsaeeteexllenceevvteeedlol,ssnsooe(ffst eFvFinCeCrat11hl.44e33 ordaatdetevwrwehslhoiipcocm hhf emttnhahtegenssoeieftuppcdhhueeem)nn,uoom mlaiitnnivaae the environmental were observed far the environmental concentrations of FC 143. exceed, (several orders of concentrations of FC 143. magnitude), 22556699..00000055 I3MMAA0011441100332200 a. -5- Fased on the results of the histopathological examination, Based on the results of the histopathological examination, 30aay exposure. fo 100 mg/l FC 148 ALY ner comeributs a 30-day exposure to 100 mg/1FC 143 did not contribute to abnormal histopathology (Fable 5). "Both. growps of to abnormal histopathology (Table 5). Both groups of oeganione Sehibi rea Teter iver shentes: S18 AEE ors organisms exhibited fatty liver changes, 6/10 controls and 35h trentod oapanions, SImiIarTe: goal Meomeriania and 5/10 treated organisms. Similarly, gill hyperplasia rebgiiediab eT rr Rath was seen in both groups, 3/10 controls and 2]10 treated ifry. Table 5 H1i8s5toma pesrithohleoigiscestl Examinatironooef Fai thead M2inow Table 5 Histopathological Examination of Fathead Minnow Fry (P4mep~aZ~. prom~Za.) exposed 30-days to 100 mg/1FC 143a,n Test Material Number of Ristopathotogical Test Material Control in it 6/10nfdatitny gliver changes Control 100 me/1 FC 148 10 455$5/313208060 ETEgrao1Totr1TtmgyeenhryLppievererrppilecanhsiainnages 100 mg/1FC 143 Number of Observations 10 lO Histopathologlcal Findings 6/10 fatty liver changes 3/10 normal 3/10 gill hyperplasia 5/10 normal 5/10 fatty liver changes 2/10 gill hyperplasia Discussion D TToTFsonhOIevSeueTnCiraUcpps5erSriiSmmITafOoaonaNrnarryy 80appl1luuprrpreSpaonoovvsvsiieeirerooasonfrfm maenttehnhniiaitassmalal rlreeyddppeiaoiaotras.rtt SgGFriiesevnpeeoettrovaoaettenippdcsrriooevvrr)eioiddlraeeeatntiviaaningtessoiinmntoomggsellenetal FC ]43 and to provide an analysis of potential environmental PBrI(IFirnnIsIAa)kcddA.teeaivvceesE allcloohppnemimioaennn dtggelelzttedhhdiibssusfbcelaaedionnsaasoiellndyytssituS ssssyestttewowfoom mFmeoConr ddveei1Tllr4Ro5nttmayyeeppneetsss wwiillll bbee ddiissccuusssseedd:: maandnuf2)actauring practical model based on use of FC 143 at a manufacturing site and consumer product usage. 1. Closes system 1. Closed System The environment can be considered to be a closed The environment can be considered to be a closed yaten, schemticely represented to: system, schematically represented as: -- soit Soil Water 7 iCC reECehoquThmenuienaam ilithliinnoiabbcanarrlccilcisouosuenm nmfeefinionnFnbthteeeeeetddtrrtw niihonwneewegeignintG.thehtthpiitthwninaiicsssovaaooosssykyssrsisintmtna4epg1kem la1lmllteeem Smt'hCichioogregehm mehetpttpaasceeCreotsosm nm tmtiapaepaebbntarltlriittssm ooahrmhr.eninppaantnon,ser,rttuubbaattee all phases of the depicted cycle. 22556699..00000066 awsotatont 3MA01410321 Spsuttiontty ve sap septevees the fapast of 5C Ws Specifically we can represent the impact of FC 143 in the following manner: NNoo PPhhoottooddegergardaatdioaLtiLo__n_ AAiirr VoVlolaattiilliitty sSooiill ~ NNoo ddeeggrraaddaattiioonn Volatility ~ Rate?\ rain 80% of adsorb~ 74 sisted oan J WZ afome te Seeman \ Water >20 g/l (gel) Sediment, No biodegradation sorption phenomena as seen in soil fs Lilustrated, FO 140 enters the environment primarily As illustrated, FC 143 enters the environment primarily by means of the waterways ana secondarily via the 2zeaneo,f nSwmsorvays anaseconsarily uly tne terrestrial ecosystem and atmosphere. This material ee ee wit Louis does not adsorb permanently to either soil and/or dons Sot Sas gemmmily fo oer enti dre sediment, remaining however in the water compartment. Treen tran En Agstale Thostee that It is not known whether FC 143 is volatile, a fact which assumes importance in light o~l~e finding that FC 143 does not undergo photolysis." " Based on the foregoing, the waterways apparently are the environmental sink for FC 143. Intermediate receptors have not been identified. 2. Hanufacturing and Consumer Model The foliguing construct illustrates virious BUNSve The following construct illustrates various pathways wherein FC 143 may enter the environment at the processing s~te. 22556699..00000077 -- 3MA01410322 i | Po. i Pop Egle Er i1 ; 2 PLA a-- / Ft nds Pi yO op ATE [FT |; hy LRATE | / Fis PL I 7jifF 23 31.) _B _aZmEi i \ /., - 2569.0008 3MA01410323 Pent -8- m mTbTyihhigeeghthtahatebbooeevnvTneteeteetrlrffioigntgtu~(pughrreee)encnvoddvineeirtpproiioinnccnm tgtmsseeannnpptdrtr..oojpjeehccoIIntttneeoddgddriisappscpacahuttuhihsswcswsiaianynyigsgnsdwuw uushssheeeterrreiooefiefinnsFFCwCFFCiCt11h4411334433 DbDbtthryyhr.aa. tttthMh:eett.ooTT Pboittiethkkhfteeeelo,o,iinrnr"c"CC(~ogoom"omw ccowm oorllaeaecetrtdidiciganginalegegl CCnpnanoorhhdoeecmFFmeCCipsichcsa11ao.l44lt33oDD giw wrivDaavaaispisssthsetieeidioocssnno,nw W,inooutdIIulhludidwwsseatsbbsreeiieniinsfggnfoefeow rnonrmerm eiamrtrhteeaadidtteoednd, Ihave depicted this no by the Teflon" "coating sign; po I have depicted this no waste situation process. Based waste situation byon by the following this information, the following CsIInlingenmdd;oiiissi~cctuu.ess,ssiinnaggsitthmheielmamarannuoufbfasacectrtuvurareteiooonff FtFCCo 1t144h33atw wioituthhtliJJneeerrrdryyabH Fooofvftefeerr,, was made. Chemolite, a similar observation to that outlined above was made. cciIInonosn"nc1vvcceiieeanew ntwttrraootatfoftiioottthnnhheeeuuaenannbbddveooeirvvrreeoccnwwoomeneneddnicctitaat.nniioonnppssrroojww jehehcecetrtreeittihnnheeaaieellnnlvvFiFirCCroonn11m m44e33enntmmtaaaalnlnuuffaaccttuurreedd is lost to the environment. SsSsaiiiinm nnmiccpapeeliliswrwstiataivtitceceerrrwwmmaowaoydoydesusellldaaurureeettniilalttihbihzelezieinneeggnonnvve&aiirroCisonoinmnmgegpenlrlnteeotajalepplcootissininintantknkssoeoffouauortrrriccemeFFCsCtffoeo11drr4433,FeF, CCnvaai11r44o33nmental concentration for and a river would concentration for FO 143 enable FC 143 under a worst case situstion: one to project an estimated environmental under a worst case situation. Wee hhtahavviese msmaiadmdepelissseetvvieecrraalmlodaaesslss:uum mppttiioonnss w whhiicchh aarree ccoonnssiiddeerreedd bbaassiicc 1)to 1) thTTiosiosttadalislsim cpphrrpaoorlddiguusecctdtit.ciioonnmoi1dssel:aatt CChheemmoolliittee aanndd aallll FFCC 114433 pprroodduucceedd is discharged. 2) 2) NNoo FFCC 114433 iiss rreemmoovveedd bbyy tthhee ttrreeaattmmeenntt ffaacciilliittyy.. 3) 3) AAlLl eefffflluueenntt iiss ddiisscchhaarrggeedd iinnttoo tthhee MMiissssiissssiippppii RRiivveerr.. 4) 4) FFCC 114433 i1ss ddiisscchhaarrggeedd uunniiffoorrmnlyy.. 5) 5) R Rhieivnvecerer nfflolotowwsuaabnnjddecaatlllltoootthhseeerarsoppnaaarrlaam meaetnteder/rsosraacrreleimccaootnnisstctaanntt,, perturbations. hence not subject perturbations. to seasonal and/or climatic The formulae used in these projections include: The formulae used in these projections include: 1l) wm n MG/min - = p ((RRiivveerr FFllooww.,a'e CCPFMM))~C(oCnovnveern rssitoonn,,ggaal//tft)3g s)((TT(iTimisneee,,.m!nm.tinna)) 2) Mo/min x 1440 = uG/DayProduction, per annum 2) MG/min x 1440 ffi MG/Day 33)) LLbbss//ddaayy == ((mmgg//1l xx w wtt.. l1bbss.. HHy200 ppeerr ggaall))(M (MGG//DDaayy)) MM TioswisssifislssosiwipppprieicoRRriidvveerrisffll1oo0ww,00aat0t CHHaFas.sttiinnggss,, MMNN,, bbaasseedd oonn aa 1100 yyeeaarr CCTaTlohnohoweemmemmoeettftlrroooiccttwniiaaalaaltllree55dcCCohhyyeeeerednmamavirriicciarsapplolrrsnsoolOmddeDDuu,Oniicctvvt0tiiai0isslooiinnCoocFnnoffS..nii. cggeuunrrIInteenssrauuttwtwiieeiorrllneeiizzoiippfnnrrggooFvvCiittddhheeee1ddss4ee3bbyyiffnii' DDgg.uut.Rrrh..eeessRRiicckkeerr,, M#atinihessSSeiipsssetssriiiimppoappdtiied1RR9Ti7evv3nee-vr1ri9r7obb5nee,lmloeownwttheaCClhheeE~mEcCooollniicftteoeerntwwFrCaaassti1occ3n3aallccwouufallsaaFttCceeaddl1..o4u3lDaDituunerrdiitnnhgeg the period 1973-1978, the EEC for FC 143 was calculated 22556699..00000099 awaoratos2s 3MA01410324 ttffthooooerrbbewet"tahnete11"e..rp6p6ee~rgrcgfio//oomlldapara1Tattt9om7re8HHan-aa1t1ss6t9t8i8ii3nn3a%ggLssti,.ahsepf?pinrren.oon.,,jjveierrwcwtothheneiidmdlleeenaattttt'ahh3iee2..4peEE4EEipCCngk/pp11rrfc.ooo.rjjeeccFSSttCiieennddcc1ee43, oeotiitfhnftevipipisswrrrooaontddddmeueeuercttcentetrtiircm oanoonlinminnpeearFFddCCirstkmtt11heh44na3au3ttnt w dwieaaiiltrstlll wttthohnnhereoeotst tppepprnrreevcreseiasseesrseneeonntnnsttmtieaatnnnaatndndeatlpupurnniroroosrnjeeljseeana.cckssototeennfddaoabrblllleeeFevCveel1lss43, ceonnveirwownsm toennstal risk under worst case situations. CONCLU S IONS U oSUsfenenldldePoeecCcrrtteet1tdhdh4ee3pp1htht1eyeysssstihticcaoosccccoohhbnneeeddmm eiiintticiicaooadlnn]essteaarnneedmdm mippnelelenoondyvyveieirddrtohonaniim tmnneentccnthhhtaiaaalsrlraamcppcatrrtteooeerprprieiezizrraititnlinigeegss of FC 143 it has been determined that this material 322l1))))) hhiiisasasss'reeeaxxannsttriresennmtm--aeooenlclctyyttaannw twooaoaltltme//ew irwrcaartsstoeooeblrrliuuabppbllalaeerr,t,dtieittgffioirooorarnm ndmaiintcncgiogooeenfaafffiggicceeltileennaatttt 2o200fgg~//11.. of~ 5 3) 3)4) 555) Siiiiinssunsrveeraainexnxvtstarreoielseggm ;tmegae-e-nltfllyryrtoyynmm gtootssohtbtubiumdioldlyifeyecrwddioineinibdidigBB ahrnnlrtiooiltdtllfleaoagfslsfrafaflaneenoddcdcwaytyittinoghnllonaoaataatmomcn8ha0ssaboobiidillialliyittyye,,xposure WSTstsoaoiuigsgrnFnFvCiCniiffvoiit11acce43laad33,nntotaalenttnddgtessegiuutghrsbbreselleueeoe.et.rthshaw aleSSleixiimam glleimehlviivtlaneearelflrldosslyyl,l,fttoooowrnnooiaanegvaassiddttdavaaveettenrii3rscss0seetetiidccoaeeayfaffllffleelecysychxtetpmoiscuarle 6) 6) whiiiinsesnadndsucuttoecocneeoddbbSteoetdsppaffaotooethuhunnononvlddlitooirsggoppsyynrru.mii.m eemsnaatrraieillxlyyam siiiinnnnke.dtthheefoNoww raatsetepvereridceiccnofoicmmcpepaariortnftmm teecenrhntmet,e,mdiicaatle 7) 7) oWwhrrefoeeoucncul`ecelddaepppttpoohhirtraarossvvsxeeihhemaaaanannvvtveeeirsleoyebbsntteeim iee1mnnm.eaa6nt-tiLtede2dadd.eel4nnpetsetgininin/fvfv1ikiiie,err.oddo.nn.am mnNedoenentrstapalcleocnccidoofininctccieeoninnnttsrtreaartwtm iihooeennrdeiiante 8) woaiainni1fltltl1ool"a'FFpCCtntphohrtoee11x44i3pM3M mriesw waissseteeseirrTinseestsysimm ippaa1apnnp.niu6iufu-f2anR Racri.ci4vtevt~euauerrsgrr:eeo./d1dna, baaltutenC Cdehehnerevmmiocrloooil~inttdmeeietniaaotnnanddlsddrw iisishcscehkhraaerrigngeedd 8) ubassiegde ponattperronssentotea.nd projected production levels, will not present an unreasonable environmental risk based on present and projected production levels, usage patterns etc. BIBLIOGRAPHY BIBLIOGRAPHY 1. M Meenandndedell,S, uApA.p.,o,rtTT"ee,cchhnJniaicncaualalryRReep1po7or,rtt::1979"".A Annaalylyttiiccaall MMeetthhooddoollooggyy and Support", January 17, 1979. 2. R ReeiSintneuerdr,i, esEE..AA o.f.., FTlTeuecochrhnonicicacaralblonRResepop-rotr:1t:11,""B BJiiuoolddyeeggr1r9aa,ddaat1ti6ioo7n8n. Studies of Fluorocarbons - III", July 19, 1978. 3. WWeleaslnshdh,, FCSS'..K K1.4.,5, oTTneecchShninidicc"aa,ll FRReeepboprroutr:atr: y 2""7A A,ddsso1o6rr9pp8tt:iioonn ooff FFCC 9955 and FC 143 on Soil" February 27, 1978 4. UUSS//RMDEEeaaPPaccAoArraoor----ciihnWMnveevetSterhehrtrootoiddebessbrsrataft6ootee0rrss0/AA3acca-nnuu7dtdt5ee-AA0mTTm 0poo5hxxp,iiihbcciibii1aitt7anyyn5ss..TT, eessE EttccoowlwlioiogttghihiccaFFaliilsshh,, Research Series 660/3-75-009, 1975. 5. CChhiiBaaooninuuddo,,acRRcooCCdudaarggrmyyeeurrlaTT.tLL.,..i, onVVKKoiiohrhormngfgeeiirrllStt:e:lHK..ectFPPFeraarderreettddiiO,,ttriigooaDDnnnaaivvcCiiCoddoeCehtfW,.eifmiiiccSSciiccaeehhlmnmmsstee,ddddaalinnnnddgg,, TEEBonnirvvotiia:rrcoocnnummmeeunnlttaaatllionSScciiofeennccSeeeleaancndtdedTTeeocOmhrnngooallnooiggcyy,,Che11m11i((c55a))::ls,447755--447788,, 1977. 22556699..00001100 a3MMAAo0t1a4t100332255 10 10- 6. HHaamEmaxkapkeeerrr,i, meJJn..W Wt.s..", ""inIInnCttheeerrmppirrceeattlaastt,iioonnHumoofafnSSoHoieilalltLLheeaacachnhidinnggthe VEEEonxnlvvp.iierrrooi1nn,mmmeeenDnntottsw,,"ChAAienmCCioCoclhlaelllmeeiccctUtaSiilAoosnn, oMoffiHdulDmDaaoonnwwd,HSSeccMaiiileetcnnhhttiiigffaaiinnccd P4Pta8ahp6pee4er0rs.s,, Vol. I, Dow Chemical USA Midland, Michigan 48640. 7. RReegg1ii7ss6ttrrEyyditooiffonTT,ooxxiiCcchriEEsfftffeeenccsttessn,ooffHC.CEhh.ee,mmiiccaaanlld SES.uuJbb.ssttaaFnnaccieerssc,,hild, EaE'ddn7ssd6.. WEpepd.l.ifxtxaivvroenaa;,nnddNCCahCiitr,,iiosntUUaeSSlnsDDeeeInppn,aasrrtttHimm.teeEu.nnt,tte oofaffonrdHHOeeEaa.cJllc.ttuhhp,,iFtaiiEEorddncuuhaccilaalttdii,oonn,, SSanaadffeetW tyyelaafnnaddre;H HeeaNallattthhi,o, nWW aalsahsIhininnsggttitotonun,t,eDD.f.CoC.r.,, OJJcuucnnueep,,at11io997n766a..l 8. WWelSettlteuerdr,i,esA A,..NN..,F, CTTe2ec1ch4hn-ni3ic0caalllotRReep5po6or6rt,t:: FebA Arqquuuaaarttiyicc 16T T,ooxxi1ic9ci7it9ty.y Studies, FC 214-30 lot 566, February 16, 1979. 9. WWelSettlteuerdr,i, esAA,..NN.P.,C, 2TT3ee2cchhnlnioictcaal6l10R R,eeppoJorartnt:u: aryAAqqu1ua7a,ttiicc10T7T9oo.xxiicciittyy Studies, FC232 lot 610, January 17, 1979. 1100.. W WelRetelteperor,r,t,AA..NFN.C.,', 95TTeecchMhnanriiccchaa,ll R R1e9ep7po9ro.tr:t: FFiinnaall CCoommprperehheennssiivvee Report, FC 95 March, 1979. 1111.. TTooddSddt,,udyJJ..WWu..s,,ingTTeeccShhinnmiiucclaaalltedRReeppSoourrnttl::ightFF,CC F11e443b3ruPPahhrooyttooll2,yyssli1ss979. Study using Simulated Sunlight, February 2, 1979. 1122.. WWelRetelteperor,r, t AA.o.NNn.. FMTTeec3ch4hn2n2ii,ccaalFlebRRreepupoaorrrtyt:: 2, FFi1inn9a7al9l. CCoommprperehheennssiivvee Report on FM 3422, February 2, 1979. 22556699..00001111 33MMAAO011441100332266.