Document pBOBXnq8d92Rj5n7qQ2w7ENVa

AK H>- tZ 000462 4 AS6 _ f y S WASHINGTON WORKS 'TEFLON*' AREA EMPLOYEE BLOOD LEVELS PERIOD 1984-86 1987-88 1989 1990 1991 POPULATION 108 58 41 21 3 < =1PPH <%> 67 50 59 90 N/A < =5PPM (%) 92 90 83 100 N/A C:s l g 1/2/92 000463 LIVER STUDY OF WASHINGTON WORKS EMPLOYEES EXPOSED TO C-8. 1/15/81 OBJECTIVE: DETERMINE IF OCCUPATIONAL EXPOSURE TO C-8 ADVERSELY AFFECTS LIVER FUNCTION AS MEASURED BY BLOOD LEVELS OF SCOTr LDH, AP, AND BILIRIBIN. COHORT: (88) "TEFLON" AREA EMPLOYEES IN ONE OF FIVE JOB ASSIGNMENTS TESTED IN 1979 FOR BLOOD FLUORIDE. CONTROL: 10% OF ALL WW EMPLOYEES WHO HAD NEVER WORKED "TEFLON". RESULTS: BLOOD FLUORIDE IN COHORT 16 HIGHEST (TOP 20%) RANGED FROM 5-21 PPM (AVERAGE 10 PPM). CONCLUSION: 1. NO EVIDENCE OF OCCUPATIONALLY RELATED HEALTH . PROBLEMS AMONG WORKERS EXPOSED TO C-8. 2 FEP WORKER AP LEVELS MAY HAVE RISEN FOLLOWING C-8 EXPOSURE. 3. NO SIGNIFICANT CHANGE IN TFE EMPLOYEE SGOT, LDH, AP, OR BILIRIBIN LEVELS FOLLOWING C-8 EXPOSURE. PROPOSED STUDY UPDATE REVIEWED WITH KARRH AND LIGO, 10/4, DECIDED NOT TO PURSUE C: s l g 1/2/92 Company Sanitized. Doesnot containTSCA OBJ --- -- u*>0464 e-8 BIOACCUMLATION IN FISH BACKGROUND; BIOPERSISTENCE IN KAN, RODENTS - NO DATA ON TISSUE BUILD-UP, STORAGE SITES IN ANIMALS; - DISTRIBUTION OP C-8 DIFFERS AMONG SPECIES; WITHIN SPECIES (MALE VS. FEMALE) WOULD C-8 BE EXPECTED IN BUILD-UP IN FISH? - OCTANOL-WATER PARTITION COEFFICIENT ESTIMATES PREDICT VERT LITTLE TO ACCUMULATE IN FATTY TISSUES OF ORGANISMS - IS THERE A STORAGE SITE IN FISH SIMILAR TO THAT IN MAN (FIND C-8 BOUND TO PLASMA) - EXPERIMENT TO ANSWER PROPOSED TO POLYMERS ! BUSINESS TSCACBI ') *M i>465