Document pB9OdZGBL2zx3BQ55zKG2y1Jw

AR226-2752 Copies to: E. I. du Font de Nemours and Company HaskeLl Laboratcry for Toxicology and Industrial Medicine Elkton Road, Newark, Delaware 19711 HASKELL LABORATORY REPORT NO. 636-79 _ ____ Material Tested_________ Octanoic Acid, PentaJecarluoro-, Ammonium Salt* Haskell No. 12,037 Other Codes Study Initiated/ Completed 8/15-8/17/79 Material Submitted by [Plastic Products & Resins Department, fashington Works SKIN IRRITATION TEST ON RABBITS Procedure: Six main albino rabbits were..clipped .free of hair on the trunk and lateral areas and placed in FDA-type stocks. Doses of 0.5 gm solid test material were applied as an aqueous paste to intact skin under 1-1/2" x 1--1/2" 12--ply gauze squares. Rubber sheeting was then loosely wrapped around the trunk and secured with adhesive tape. After 24 hours, the rabbits were removed from the stocks, the patches taken off and the reactions observed. Observations were also made at 43 hours. Results: 24-Hour Observation Erythema Edema Moderate 3/6 Mild 3/6 Mild 1/6 Slight 3/6 None 2/6 48-Hour Observation Erythema Edema Moderate 2/6 Mild 3/6 Slight 1/6 Mild 1/6 Slight 2/6 None 3 Octanoie Acid, Pentadecafluoro-, Ammonium Saltil aused mild to moderate skin irritation in urs and Eslight to .noderate irritation in 48 hours when tested on che shaved intact skin of rabbits under semi-oeclude dit __ |ay cause mild skin irritation upon repeated contact. Cood industrial hygiene practice would be to minimize skin contact. * Com po s i t i o n :\4[ tam ina nt ^ STIn the event of any skin contact, wash thoroughly with soap and water. Other Names: >ns. bh'E:scg bate issued: October 1979 Report by: Approved by: / -W - Doris F. Edwards Toxicologist _>_L Gerald L. Kennedy Chief, Acute Investigations Section Company Sanitized. Does not contain T SC A CBI