Document pB13O3w10BERDyd4GxBayB0B7

PO Box No 6 Bessemer Road Welwyn Garden City Herttofdshir A17 1HD Telephone Welwyn Garden 23400 (STD Code 07073) Telex 264251 From J Stafford Division Manager Health & Environment Protection To See Circulation Below Imperial Chemical Industries Limited Plastics Division Your ref. Our ref Tel ext Date JS/MJE/DS0-107 3162 26 February 1979 PVC DUST BIBLIOGRAPHY Some time ago Dr Torkelson of Dow suggested we put together a bibliography of papers on PVC dust. Dr Pigott and ICI's Information Group gave a listing of 340 references many of which we thought too marginal to be of interest. With Dr Pigott I have pruned this down to the attached list of 37 published papers directly concerned with PVC but also including relevant review papers on tissue culture reactions to plastics, dermatitis from polymers and additives, systemic effect of leachables. We have collected all but 9,13,14 and 25 and I have photos of these papers in one file if you should require copies. Paper 25 is being translated; papers 9,13 and 14 should be on file shortly. If you consider that there are significant omissions please let me know and I will add your references - I would prefer it if you would send the papers^ The French works medical officers have a paper in the press about th pneumoconiosis case described by Arnaud. From our own laboratory w hove several papers in the publication pipeline and will add them as they c m out. Regrettably we also have one paper by Burrows et al which has not been accepted for publication and this presumably goes into limbo. Perhaps we will be able to retrieve this situation somewhot after the Institute f Occupational Medicine completes its study of a sample of our Hillhous Factory population. Dr Torkelson did also suggest that we include unpublished work and work in progress. This is more difficult. We have of course the NI0SH Chr nic Inhalation Toxicology Study by Dr Kommineni which was notified in T x-Tips last June and the DHEW memoranda of May 5 & 10, 1977 for rats and guinea pigs and September 6, 1978 for monkeys which I have already circulated widely. We have Waxweiler's thesis ond paper to the September 1978 Medical Congress in Dubrovnik. There are the Italian epidemiological surveys and more recently a paper by Mopp ec al (Med Lav Vol 69 1978 p 151-162) which has been translated and circulated - this should now really go on our list. Dr W G F Adams will visit Prof Mapp et a! in Paduo in March to discuss this paper. Ucc 010876 2 In Dr Greenberg's summary which I circulated with my note of 6 February for the APME Meeting on 27 February, there is c reference to "Pathology of Polyvinyl Resins" by G Broussard (1969) Folia Medica 52 p 102-8 which looks unpromising but perhaps should also be included - T"will get a copy. Any help you con give in updating and completing this portfolio would be appreciated. Circulation Dr W G F Adams Dr B Bennett Dr D P Duffield Dr M Sharratt Dr P Grasso Dr J T Carter Dr D W Plester Sir C Lowrence-Jones Dr F W Best, Everberg Mr G J Sleddon Mr B Hosier Dr D Scarisbrick Mr A E H Williams Mr T L Phillips Mr H M Clayton Mr T W Moffitt Dr L de Boer Dr J G Kammuller Mr J C Thomas Mr M Bonnefoy Dr T Garlanda Dr M N Johnson Dr T R Torkelson Mr R N Wheeler (Jr) JS(10) Dr R E Davies, ICI Melbourne Mr K H White, Duperial SAIC Dr T Bougas, AECI Mr A G Wheeler, ICI Americas Dr J Conbere, ICI Americas Mr M J S Gibbons, ICI Americas Mr P Rongnes, Norsk Hydro Mr Sv Wejdling, Kemanord Mr 0 Kansanen, Pekema Dr R Praefke, CWH Mr H Emminger, VKE UCC 010877 THE TOXICOLOGY OF PVC (PUBLISHED) 1. Agarwal D K, Srivastava S P, Seth P K (1977) Effect of polyvinyl chloride dust on rat lung. In Environmental Pollution and Human Health, 282-291. Proceedings of the International Symposium on Industrial Toxicology. Nov 4-7 1975. Ed. SHZaidi. PubllNSDOC. 2. Arnaud A, Pommier ?, Garbe S L, Payan H, Charpin J (1978). Polyvinyl chloride pneumoconiosis. Thorax 33 19-25, 3. Baxter P J, Fox A J (1976). Angiosarcoma of the liver in PVC fabricators. Lancet l (7953) 245-6. 4. Bell F P (1976). Polyvinyl chloride plastics. The enemy within? Artery 2(5) 384-389. 5. Casterline, CL, Casterline P P, Jaques D A (1977). Squamous cell carcinoma of the buccal mucosa associated with chronic oral polyvinyl chloride exposure. Cancer 39 1686-8. 6. Cylwik B (1972). Histological and histochemical changes in liver during experimental PVC pneumoconiosis. (Roczn Akad Med Bialymstoku 17 93-11 1972). Chem Ab$tr 78 67842 (1973). " 7. Duck B W et al (1975). Mortality study of workers in a polyvinyl chloride production plant. Lancet II (7946) 1197-1199. 8. Dvizkhov P P (1960). 0 ccupational Cancer. Gigiena Truda Prof Zabol 4 3. 9. Dvoskin Ya G et al (1969). Toxicology of some polymers. (Gig Sanit 34 (1) 7-11 1969). Chem Abstr 85812. 10. Filatova V S et al (1974). Hygienic assessment of working conditions and health status of workers In the production of block polyvinyl chloride. Gig Tr Prof Zabol 18(1) 3-6. 11. Filatova V S, Grensberg Ye Sh (1957). Sanitary hygienic conditions of work in the production of polychlorvinylic resin and measures for their improvement. Gig Sanit 22(1) 38-42. UCC 010878 12. * 13. * 141 15. ` 16. 17. 18. 19. 20. 21. 22. Frongia N, Spinazzola A, Bucarelli A (1974). Experimental pulmonary lesions from prolonged inhalation of PVC dust in a work environment. Med Lav 65(9-10) 320- . Gabor S et al (1964). Biochemical changes in workers occupied in vinyl chloride synthesis and polymerisation. (Igiena 13 409-18 1964). Chem Abstr 62 9683h (1965). Harris 0 K (1962). Health and safety in the plastics industry. Plastics Inst Trans J 30 No 86 028. Hodgson G A (1966). Industrial dermatitis. Postgrad Med J 42 643-651. Karstadt M (1976). PVC : Health implications and production trends. Environ Hlth Perspect 17 107-115. US Department of HealtTTEducation and Welfare WHO-NIEHS Symposium on Plastics Manufacture. Lange C-E, Ouhe S, Stein G, Veltman G (1975). Further results in polyvinyl chloride production workers. Annals NY .Acad Sci 246 18-21. Li1is R, Anderson H, Miller A, Selikoff I J (1976) Pulmonary changes among vinyl chloride polymerisation workers. Chest 69 18th Aspen Conference. Li 1is R, Anderson Ht Nicholson W 0, Daum S, Fishbein A S, Selikoff I J (1975). Prevalance of disease among vinyl chloride and polyvinyl chloride workers. Annals NY Acad Sci 248 22-41. McGinty L (1975). PVC dust fells factory mice suggesting new work hazard. New Scientist 26.6.75 714. Miller A, Teirsteln A S, Chuang M, Selikoff I J, Warshaw R (1975). Changes in pulmonary function in workers exposed to vinyl chloride and polyvinyl chloride. Annals NY Acad Sci 246 42-52. * Misgeld V et al (1973). On Intoxication via vinyl chloride polymerlsates and/or their accompanying substances. Z Haut Geschlechtskr 48 426-436. UCC 010879 23. Parmeggiania L, Sassi C (1955). Occupational risk and pathology in the production and manipulation of some plastic material. (Med Lav 46 14) Chem Abstr 49 9317h 1955. 24. Pigott G H (1976). Studies of a range of formulations of PVC. Polymer ''reprints J_7(1) 29-34. * 25. Popow J (1969). Effect of PVC dust on the respiratory system of the rat. (Rocz Akad Med Bialymstoku (Suppl 24) 5-48 Chem Abstr 74 74463 (1971). 26. Richards R J, Desai R, Hext P M, Rose F A (1975). Biological reactivity of PVC dust. Nature 256 (5519) 664-5. 27. Richards R J et al (1976). A surface active agent involved in PVC-induced haemolysis. Nature 260 (5546) 53-4. 28. Rigdon R H (1975). Tissue reaction to foreign materials. CRC Crit Rev Tox 3 (4) 435-476. 29. Saric M, Kulcar Z, Zorica M, Gelic I (1976). Malignant tumors of the liver and lungs in an area with a PVC industry. Environ Hlth Perspect 189-192. 30. Styles J A, Wilson J (1973). Comparison between in vitro toxicity of polymer and mineral dust and their fibrogenicity. Ann Occup Hyg J6 241-250. 31. Szende B et al (1970). Pneumoconiosis due to inhalation of PVC powder. (Med Lav 61 433-436 Excerpta Bed Occup Hlth & lnd Med 2 (12) 2366 (1971). 32. Thomas J C (1977). PVC and Safety. European Regulations . Gaout Plast 54 (571) 33-33. 33. Vertkin Yul, Mamontov YuR (1970). On the state of the broncho-pulmonary system in workers engaged in the manufacture of polyvinyl chloride products. Gig Truda prof Zabol J4 29-32. 34. Wilson R H, McCormick W E (1960). Plastics. The toxicology of synthetic resins. AMA Arch Industr Hlth 21 536. UCC 010880 35. Encyclopaedia of Occupational Health and Safety, Geneva. ILO 1971 2 1467. 36. Preliminary assessment of the environmental problems associated with vinyl chloride and polyvinyl chloride. US Environmental Protection Agency PB-259 110 NTIS 1974. 37. Vinyl Chloride, PVC, and cancer. Lancet 1 (7870) 1323-4 1974. ucc 010881