Document p7NEYy5p1YgkMqNN0ndJNZV6

MnaeSenrvicoesn Teor. SOCP BMN $5133 .33 S78 saz . ARLE -095] on EHR -- O00 -- 373 wreencoican \ Laboratory Report | Report of Data for Exploratory 28-Day Oral Toxicity Study in Rats: 1 Telomer Alcohol, Telomer Acrylate, , PFHS, PFOS | Laboratory Report No. FACT-TOX-120.3. Requester Project No. NOTOX #242933 | Testing Laboratory . 22 on 3MEnvironmental Technology &SafetyServices TEE . Fluorin3e MAnEanlyvtiircoalnmCehnemtiasltLrayboTreataomr(yFACT) Ea l } 2-3E-09 | S9t35PaBulu,sMh ANve5n5u1e0,6 -= i J . Laboratory Contact J Kris Hansen, PhD. ] Bldg. 2-3E-09 P.0. Box 3331 o StPalMNssiml n 8 EPA-OTS ] PFhAonXe:: ((665511))777788--66107168 Armin --_-- | a & W[w,a" T CI y i 23 I i Requester `MarvCase and Paul Lieder Tox3icMolCoogmypSaernvyices * S2t2P0a2ulE,-M02N Reponissued 41199 000448 ! wEwRORWeENrTAoLFALRCuTsTToOTNRO1.R3Y0 "Thisshud wasdesignedtopreliminarilyassessthetoxic ofvarioustestarticlestothe femaleSprague | `Dawleyret. Test animalsweredosedbyoralgavage th followinglevels: GGroruopu23p::TToeommeesrAAlccyolhaotle 3300mmggkkggllddaayy . ] GGrroouupp5:: PFHS 3100mmggghlgiiaayy . Group: PFOS . 3mgfgfiay ] `Witkincachgroup,8animalsweregiventestmaterial eachdayfor28days,andthenscifi.Three 1`a0nriomavleswrefroera2l8ldoawyesdtboef"orercesoavcerri"f(inceo.testmaterial for 14daysbeforesacrific;threeanimalswereallowed. 1 `Lquiavnetristaatmipvleelsycfoolrlpeecxteidvforooocmitahneessauclriffoincaetea(nPiFmOaSls)waenrdetsheenrptoetchhoerEixnviartoendm,esntuallLoabnanadtaoneal-cyazbrebdaoxsyleicd-- . acidbasedmetabolites. (Afulllstof acronymsan formulasisatachedin tachmentB). 1 eTxitsrsaucetsswaemprleeqsuwaenrtieatoivmeolgyenailzyeze(diuvsei)nagnhdigehxptrreascstuerdesliinqguiadncihoronmpaatiorignrgaepxhtyreaclteicotnropsrporcaeydtuarne.dTehmem.ass `Specrometry (HLPCa/nevEahaStedvMerSsanMextSract)edcu,rve. Analdetaytareiavaciaablelin | t`hesmtudeybitnidsaedretmbearmoiinneldtbiyabiynitsFpnAeecCetTids.onT.hepresenceorabsenceofknownfluorosbemmicalcontaminants and. Sixprfocinatedcirbonylic acwerie ddecsidintelvesampleexacts decvedfrombothgro2uanpd | gr3oaniunuapls (seeAttachmeDn)t. Fdeocrrgeraosuip?nathnedgcroonupc3e,InvterrsoaffrtPoOmiAoAan.lTeahnedcfoenmcaelratinioafitnobootbhegrrocuapbsorofylrieccoavceirdybaanseid ashowed :a | fuorochemicalsmeasuredquantatvely(MS13,M513) idnotshowas sigificantadecreas overthe 1 `drecoveery pteraisodes.tTahnrdearcodnmmcaetnetrriiaatiiosnnnsoofaetvharieleadbolteh.eOrtchaerbopxylicracidl-basoeurdpcrotmoaplouyrn-dusocrioiunltdeandomtebttea:boleites: . | m`amtaeyrbieaplresentinthe ratliversacupesalyzed,buttheecompoundscamo- beconfinedwithoutsiandard dReeltaetrimvienteodiPnFOvSelresvaemlpslienstshhecoowreedspaodnrdaimnatgigc derceoaasneiuimnatlphse,day 1(4agrnoudpa4y)2a8nrdecPoFvEeSry(ggrroouupps5.lWeivteklisn ] eiancmhegtrbooulp,issammopfltehessthesotwceodrmaproeulnadti.velylargestandard deviationwhichmay ind~icatevariablyindosingof ] i`nWliitvhetrhesoexfcmeaplteiaonnodffePmRaOlSadnoismeadlsa.nFimoalesxa(gmrpoluep,6,vetrhsefrrovmer1s4ddraaymarteiccovdeirfyfgrreonucepi3nfteartgaeltasranaitmeallsevels . `awenriemdae.termine to containtwoanc ahalfordersofmagnitudelessPHSth hecomespondingmale: | 3 gi and IMEnvi | `G`poroodPcLeabsorrawaetlrooereyfPorcslalcetoiweyess.,:.hDTdehaitcqeurdiastiastsiiondootfsetuhriitsaidblaeeafiwoagdsihnsotttbuqntueiiosntstaoeanaycogallevoctaevd aiaceciaobrgrsdeilinnncgeeyi0.manpdpeelfiecanasbelotef ! "`Tmhaitessriuamlm.Aanraylsyhtoeumleadnsoutrebmeecnotnsswideereemdatodbeeualcyoomnplheots:cveonmtpooryuonfdasldlemeemaebdoblyteFsAaCsTocaisatedewliyt0hbhee test. | `present.Certainothercompoundshavebeenidentifiedbutcannotbequantitatedasstandardmaterialis not | 000449 : ` | TO evR"onReENmG.PFAsCOoTTRrGRrT12y0 || Lwiivtehrtshaemspleasamvbpeutlwfarsoeizeinsaat,theEunpvoinrreocnemieptnbtytLhaebE0v0ir2o/n3u5n.etAac lLab. hcustoi dywasn notsubo mited ] ort se Co ES i 1 Aul"yFtACiTca-lMm-LeOt,hEoxdtrsacion ofPotassiumPecfluooctaneslfona ofOther ionicFurochemical '`SFuArCfTac-tMa-n2ts.0f,roAmnLailvyesirsfoorfAFnoaolryoscihseUmsicianlgHiPnLLiOvEerSEMxSactUsingHPLCElectrosprayMas Spectrometry . | | | `S(aAmTmpuBllAeyp)erienpeaxrpaHaccttoiaeotdnrfoaloqlmueedaoeuxavsmsiparolmnpemlmeeanstt,.xTEhvPieLtchCaftEoiSopnMiicSnrMegaSg:erneotangseenlpetaclt[iievntelagybnetixayrtg|raeatmcstaminooinnoinuicmyorroocgheemnssiuclaflist.e b`Ountcyelteheers,odnreTdB,aAndriercsonfosrtmueedd,itnemaenlalayntoelsfotrraMnSsfaenraeldyisniso. os-plarcganicsolvent(eye: | 'H"cPILoRClB/PoELnSCMB,SaasnaeanldiquEtothoeFfafcixnLtitaycoCiftjh/eecfntoeEraddtaeentSadfipolaeMtsdhsqeeusSdatltaihttriMaootnuiagvrhSeypawaro:esrvekerisenpthheasceoiluimdn crehlraotimvaettoogtrhaephiucid | `ncahlitlesephxatsrea,citehdeBasyonamatveeSriirnettmhaiinseadn.faolrysaiRschweaersarceitemrnaitsHtcihcseadmeoonuvtnhteeofHPmLSeC.aFsoreremxFaOwmpSwliet,lhiinnoa1sn%taonddard . 1 crFcgiaocntilconcoolHmfpmPoooLulCenwcdsuespli,aarrnanictouisdog,inn,gsSgAeSunoeMrroalcSlhyepmaripocevariladstee.sEdlaatecarteprloadstpiarvnealyay,mcaicnlrdioatneimzmapeteaironansttuefrcoehsna.inMqaoullyeezucisunegleaspwarrisedaerirlonynigzfeeodro,f 1 ``nsudbseqpureinmtacryoilono,nchsacrraecatteersimsalloefrtsheecaonnadlayrtye iiosnsieclefcrtaegdm.eTnhtisusnfiqouse tboortphbrairdmeadrwiytihoh,iwghh-iecnheragrye gas, 1 {iFesosraecgusgembcpeonlntede,adriyntfPoroaRgbOmeSenrt(osnGisFssduSec0teh4ca)taed80lnadmycan,(boere4ss9epdiotnodsidnisgftfoorSeaaOis)ati,hceP3hO0daS23fc0raoemromst(heCmFcoaSmy)poa.u,nETdahscihisaotn | `sneicgohntdhaarvyeftohnefrsaagmmeencthaatriaonctpiattiecn4s9.9aim primaryfon btdiferent chemical compositions and 51 Calibration | iAnsmtirduemevnetlal,edxittr.acCtaeldbmraattioxnccahliebcrkastaionndcahredcskaseancdomaprldiiasnatnaiflyiznesdmeevenrtya5l1e0posarmspelesswtiotmhoins+i-tx30% of | theexpected abe. | 000450 |! : uvR`ORMEevoL.pFLAuCsoTonR0t%ro1r3R0y . Quwanotietxattriaocnteodfmtahteitxarcguervteasnlbryatcekseitsibnagseeadcohnglrionuepaorfresgraemspslieosn.anQalysuis a(weirgohftctead1chixalifayapptriospbriaiasteedo)aofnthe i| rienssptrounmseentof.oneormor specificdangerons sing he ullresponsmonitoringmodeofthe 52 Blanks | TAwddoietoxnatl,rtwabolacsnkts,uuiilozmoifnnbgplwaanktlmearatssis,uTuosgeadtfeomtahteiex,traaectedcraalciebdrawtiitohnccaavcehsb,acrhe oefxtsraamcpteldessl.ong itheach eichof samples an curves. | {`hBilsansktsuadye,calolmbpalinaknstwiefrenoctaorgmetpalna.ly is detectedabovethelini ofdetectionforaspecificanalyte. In ] 53 Surrogates : `Tmeornaitohryeddrtoopceocfmoiccrogorcotsasneinssutlrfaomneantteifsulserdiafsc8essuarro.gatefnthisanalysis, Surogateresponseis 1 54 Matrix Spikes ]. a``nDRueupcaloivlce.artiEeesxmaocutetrpsiitxdaessptinhkoietsreaandnaiglnyetmsheaesyubteielsirzoiln-gcabvlalel,ttaerrdeg.ceotvaerziaelsytweeswreerwepireiptahreeadcaoncdpaanballeyzreadnfgoorfan7e0c-o1n3t0r%ol. 55 Laboratory Control Samples | LaboratoryControlSamplesarenot componentof hi shady. ] GSirxopueprafomraatse(dsceeAsachbmeoanctindDs)we.yreldeiificedinthe versampleexactsdived rombothGroo2nuanpd. . | `duFeoocrrrogecrahoseuempii?ncatahnledscgmroeoanuspcu3re,elndivtqeurroasnaftriPttoOaimtAmioAva.enllyeT(ahUnSedLcf3e,moaMlSeLna3n)idcmdaonefoittnvnbsohototthwhagerrscrosauirpgbsanoioxffyitrcleaincctoiaavceidrdoeybcaarnesinaemsdaolvsesrhtohweed a : ] rdeectoevnemriyoepde,raiosds.aTnhdearcodnmceanttraatiiosnsnootfatvharleibolteh.erOcbaerrbopnyleacc-btasoodopcaoormtpaorluyn-diosrcionunltdaedomttebteabeolidtes: `maybepresentinthe at versaaplesaalyzd,botthesecompoundscnn be confirmedwithoutstandard. ] f`doReetleartmivienteodPinFOSelrevseulmspilnstshehcoowmeedspaodrnoadmianstgigcrdoeucpre6aasneiimnatelhste,day1(4Wgaroiudpa4ye)2a8nd oPFvEeSeSy(ggrrooiuupps5.)lWeivteklisn 2 abno ettcompound. [I i`nWlitihvtehseoefxmcaeplteiaonnodffePmFaOlSeadnoimeaaln.iFmoarlsex(agmrpoluep,l)iverhsefrerwomere14ddraymarteiccodviefrfyegrernocuespfSnfteamrgaelteasnaanliymtaellsevels | `wer determine tocontaintwoand efcdersofmaid es PFSth hecomespondingmale i i J TT | iTnhtehsesrveseurl.tsReilnadtiicavtertatheaoifncglteaornanocefceaancbheodfehteertmeisnemd.ataleadstosone acurvltionofmetabolites . ) 000451 i ' . wa"rRENO.PFUAOsCoTrROTRoT1R2Y0 ; . i EEE `Samplesam extracts wilberetinedfo futureevaluation,if necessary. i | 99.21 AAttttaacchhmmeennttAB::TTaabblleeooffRFeAsCulTtsaocfrAonnaylmyssainsodffLoirvmuelraSsamples ] 995345 AAAttttaatcchhmmueenntctC5D:::hGCCrharmopotmcateatlogRnreaspudthltiyscrbeysuGlrtosoufpaPnFdCGAeinnvdeesrtigationinGroup?andGroup 3 96 Attac: AhnalmytiecalnDatta | | Po Of A (Don TiaGeren, AyiaCoit. : Lifas Date || `is ataA en,PAD,H Princie pal Aalydal lvesigair b/n/99 Date 7 . 1 . | . 0 . . 000452 | 3MEnvironmentalLaboratory n- FA luorn inealyCht emisi tryTc eama (FAl CT) - | pacr-rox-120,RatLivers ) 28-Day OralToxStudy byDailyGavagien Rats | PFOS (C4F175057) | `emalc) Day1 Day 14 Day28 G1 "0.086 +/- 0.046| 0.102 +/- 0.020| 0.329 +/- 0.060 ] G6 3774-31 2404-25 1914-15 ] Dayi Day 14 Day28 G1 0.133 +/- 0,030| 0.255 +- 0.122| 0.099 +/- 0.007 1 G6 419+-86 309 +-34 2374-25 . 1 PFHS (C4F 138057) | `emale) Day1 Day 14 Day28 Gl <MDL <MDL <MDL | GS 97.0+-147| 0264-012| 003+-001 Day1 Day 14 pais | ] G1 0.055 +- 0,020| 0.129 +/- 0.088| 0.089 +- 0.019 GS 3274-52 61.9 +-11.7 3634-74 J a . : * cmale) Day1 Day14 Days Tn ] GI _ <MDL <MDL <MDL G4 0374-038| 0.02+-000 <MDL | ale) Day1 Day 14 Day28 G1 <MDL <MDL <MDL . | G4 3.09+/-1.58 | 0.126 +/-0.084| 0.025 +/- 0.015 | | 000453 3M Environmental Laboratory .- FluorineAnalytical ChemistryTeam(FACT) FACT-TOX-120,Rat Livers 28-Day Oral ToxStudyby Daily Gavage in Rats POAA (C,F;5C0;) . | (Female) Day 1 Day 14 Day28 [) <MDL <MDL <MDL | G2 0.164 +- 0.035| 0.016 +/- 0.010 <MDL G3 0.112 +/- 0.039 <MDL <MDL ] Q GT Day1 MDL Day 14. MDL Day28 <MDL 1 GG32 68.65494+--21.4186| | 33.35694+--106657| 11.276644--002434 ] M513 (CoF15C0;) | emale) Day1 Day14 Day2s G1 <MDL <MDL <MDL G2 1.69+-0.18 1364-002 | 2244-022 | G3 1.20 +/-0.30 1204-009 | 0.812+-0.188 - Day1 Day 14 Daj 1 [3 <MDL. <MDL <MDL. G2 1914-0388 1.73 +-046 1524-032 | G3 1784-031 1.08 +/-026| 0.801 +/-0.148 - : 3 ` He ] M613 (C1; F235C0;7) ] Female) . Dayl Day 14 Day28 [) <MDL <MDL <MDL G2 | . G3 0.117 +/- 0.020| 0.085 +/- 0.019| 0.101 +/-0.012 0.029 +/-0.017| 0.035 +-0.015|0.036+-0.011 Day Day 14 Dayz | Gl <MDL MDL MDL G2 0.087 +/- 0.015| 0.107 +/- 0.041| 0.106 +/- 0.017 | G3 0.0622 <MDL <MDL . i L C5,Cl1mdC13peterinaedcubic cidesdetectedin G2md O3 ils ! 3MConfidential 000454 Ee Bp F-38 an } SRERSRIESS. . 3 ETT EEE(EETEE EeTT rr tr trrT a EERE EEL EE oom] we ae I2 =1 wm [nl=| m wm |@| ow | wo rir rir rrEr i =. fr---- . CFE EETr trTeETaate a=a rar[aat[ =ta oie ia=t=[=n 2 8 EE LL ELE LE E =rE EE EHEL LEE Ex T LEEE LT L brre erEe rE Ea Ewa 5 ai CE ToT me wm [ee a a am eel TL[=] g 8 EEL EELLE LL EELEL LEE LE LL EE LEE E i LL] Crm|BE oe 8[ow (2 lafTe] 2[1| = Emme pr : 2 C CE E o mE rrEerTmETaaT[eaTro[a2eTTaae m(a RTe 2[o=n[[==] g$ EWeEEiEH Eee. ga2 IMmlrcsad a2rcealra 0E tIY arcalrRENreETrcellrHealrHN1 13 CTT TT Teed TT TT TT TT TT HEEL EERE ee 3 a IMli 3 alPNA CRPc IIl YAE P E aal ee 23J em = mR mm PE TE EEE TE ESTe Em w]e al] g Eom rePera eee eo] 8 Sb EALEe LrEERrELTLr eTEEELTaLe EE ELE tee ET eare eae a=] bFm REEEE EEE EE L Te EEEr Ee Ess FLT] a mS ------------ 3 CE ETErs EE re Eee] = g Fede reParte epee a =e] Foetus BEERee] STEALELE (Sef ae Te CoE e AEHEIIRN HANH (Sel [EEE oe aa.[] EEELE E EEEREEI EEE E E EE [ 3M Environmental Lab - Fluorine Analytical Chemistry Team : PFS's 1 1 PFHS PFOS ppeerrffllsuoorrooohcetxaanneessuullffoonnaattee C6F13503- C8FI7503- | erosa PFOSAA C8FI7SOZNH2 C8F17S02N((CH2CH3)(CH2C00))- Mss6 | msn C8F17SOZN(H)(CH2C00))CEF17S02N((CH3)(CH2CO0))- | PFOSEA _perfuorooctanesulfonylethyl Erosson amide `CCS8FF1177SSO0Z2NN((((CCHH22CCHH33))E(DC)H2CH20H)) B PFDS perfluorodecancsulfonate CI0F21503-** | cas POAA perfluorooctanoate [ ME M613 reso perfvorododecanoate M63 | MM36633 CTF15C00CSF19CQ0ClIF3C00CSFITCO0- ** CCEIF0IF1231CC0000--**** -- PFS = perfiuorinated sulfoante | PFOA putuotiated abaylcsid | + 10 standard material availableforconfirmation; : : | . | 1 000463 3M Confidential - Attorney/Client Work Product Privileged - Do Not Disclose | InMale andFemaleRatLiver, Group 4 3M Environmental Lab - Fluorine Analytical Chemistry 08 `Team, Project: FACT-TOX120 5 ] 07 a5s 06 35 | 3 ] Soa4 225 i i0 i 01 \ os ] o _-- : 1 14 1 Day 1G 10 P`F3MHES inn MavTleeaima,LnPardrboFo-ocFetumoanrPliAenCmTRATnaeOatlXy1Ltni2ivc0aelrtC,hGeamriosutlrpy5 "0 | 10 000 Lo ot | fo w20if 150 = 50 3 : 1 0 1 14 2 1 Day PFOS in Male and Female Rat Liver,Group 6 ] = `3M Environmeaem,ntal LPraoebct FluoFriAneCAnTalyOtical Chemistry ww || =-w =|o iwif Be = 2 150 i 100 200 @ - 2 | 01 B1ly 0 000464 | ] | | ] 1. | | 1 ] |} i ! ' os PSMOAEA inn MaTvleea,aiLnaPdrborFjeecFmtuoaorlienneRAPnaAaCtTml-yTLOtiNivI2ece0arl,CGnhremoiusspty2 0 o> s 73 015 38 1s6 33f8 HE i 0.050 1 1 0i2 , br a SME51m3 ian Maale anodbFeFmralaetRAatmLaiivear,CGrromoiuepey2 | :25 BBs i.' 0: i.7325 153 s m Fee=--v-o)| , 4 By oe oosnt ot &b0e i 0.04 oa0 Team, Sojoct FACT TOX120 M613 in Male and Female Rat Liver, Group 2 3M EnvironmentalLab -Fluorine Analytical Chemistry os one oorndi _ P0sH omg : PS [=remaetreia]],2 000465  000466 l060899007 1| 1 " . slosomiaue 22 aman ssa [061008 FTTCIIFZS' C00) "8 sn u 7: MRM of 1 Channel ES-| 598 TI G10 Pee" an us sas 3: MRMof | 1EESs-| 100] 1 % 2% 057 148.16 222 281 328 376384 ass 536 6446.80 74482 gp Tym 1 {061 089900 1 FSETCIVEZICO0) i 6: MRMof 1 ES-| sm TK ]3 061089900" sl 5.55 9313 2 of 1 el ES-| TIC - su ] 1060289500 v 5 5 of 1 ES 4 FSSCRIT) | [ERE 1] {0160899 . + PURKTCTITSCO0 127 ~ 1H of 1 ES-| 513 TIC 0 I]06089900" % 726 " ass 4: MRMof 1 1TESI-| || 51 1.4 2 3 4 EX 6! 7.00 8. Fime| . 000467 | 101600899009 TCC) : sas 3: MRM of 1 Channel EhSn-| 1056] 1 % [la 069075 106089900 100. 1 172212334258 3."04C,331 3.5 440, ' 54305. 5.65] bd sm 639 771.736 5 360 6: MRMof | 1ES5T5I ]% sa ln um Hie sEamanl an ae536 62675a73,Cree B14 829, ] po{osossso I sss 2MRMOof 1 1ETSI.| seed I] w . i1 089900 ' sss 536 5:MRMof | ES-| .3 TIC . . ] 5 p | [06089900 s|i 1H ~ of 1 1.el5ET6SI-| "0608T9o500; | EOSTEE00) 0 Bl 4:MRMof 1 1ETSc }1] 06 108 164 gpHam,STmAyVA 42 491 6iy 47588 00 657" 729)[795807 5 I ss i 10 24 3 4.00 5 6. 4 8. Time] 000468 | FTOX-120; 113F-G2, liver | [7030299003 Soup 020199 1s | 2 ods 120180258 33 .1030299003 ] amo sm ees 1m 02-Mar-1999 10:28:00 021 6: MRM of 2 Channels ETSi- 1.673 srs) [108 wis, 11.568 BZuw us a Ee 5: MRM of 2 Channels ES- 5.234) ] 1 03.0299003 1 | ' 828 . 4: MRMof2 Channels ES- . 33T7IeC4|| | >1030299003 . I | 268 3: MRMof mc] 2ChannelsES- 1.05e4| % k: 030299003 1 1 ' | | [i 9 030299003 626 Pp a. 2:MRMof 2ChanneElSs- TIC| 3.633 nes =551 1: MRMof 2ChannelsES- Pl 052101 121187 | 66 2.00 300 4queergaL sa [lea 48'M 7satwo 4.00 6.00 8.00 5 oss Rio 10.00 nnywh 1256 13;36 : `Time 12.00 000463 * [TOX-120; 131F-G3, liver RE030299005 Soup 020199 02-Mar-1999 10:57:01] 916 6: MRM of 2 Channels EoSe- 832 } | #02 92 093145 265 mas : 3 oe),682 Rgea n | 1031959 1170 18 | |e p1030299005 a7 5: MoR f2ChaM nnels EES-o | ]% 4 016 sg 1 1030299005 1 | L : py 3353, SN 1.06e3) ' 628 TB aso PR ogrioas wu HE 13s 8 . 4: MRMof 2ChannelsETSI-C| 1244) | | 0v303299005 76 3: MRMof 2ChannelsETSc-] 785| . | 925,119 P4225 36540] 463 sass ges | |Jeped0T 00 BF 122 pag o ] pr030299005 70 . 2: MRMof 2 Ic) ChannelsES- . 3.893| I [E7FIsC00} [!I 260 |bol 030299005 2m 625 g 1: MRMof G2 2ChannelsETSI-C| 879 1015 107457 :: % REY194 3 3 57 sx eps202167 [pos 9.88 1216 1295 1334 oa 8 Time, 2.00 4.00 6.00 8.00 10.00 5% o E 000471 BEER Ltr HH on Ay Ssmh. rn S Heriot fg EE ee TE E CES ES Eeem aa naE eE [[llds Ee ea e aa | IS F -- E e E e ES s Re RE EE I RRma TT Smeal enses GBimnSevero SEER SESE PRE Ret Re TT EEE SEN hE E E: o eoeT e oora po iB3 e go Errr er p h re eao] e r LToo i e E E Te e a e eeee Leabee] rT a eae| Ee re TPR a [20.266 I r RAMaia Ca Eg [RT akin ove mf133]| | 88 [E dail si ale Cer TT TheLLL To8 7Goll ialomabin| Clery TT The [TTT Flammr= jy) Coders TT Tp TIT Tae oul] [ane rv pein TT Fg[moder ey | Colac TT Tee [LTTTa[1 Cee TT Ti TTTTTTT Togrfmmmn ww wae 7 1 rrr e TT TTI T [ees oo A Cl ee TTP Tel ie 7] Gol 1 ToT TITLE ofame [ol rrrrrr Cel rrr Gol ----1 FFP | toms |Relinquished BylAfilation | Time | Date | ShippedVia | ReceivedBy/Afflation | Time | Due | ---- EL Tea e es1 PTT TpT ee al pr BEIGOP AVAILABLE | eee TT Chainof CustodyRecord 09715" [or Mooi Cow | [RETphotu e[34] s||P(B e oomp some-- Cer TT Tmee LLLP ETTT28 7 = 7Glinfin | Clete 1 1 Twe[La = we | Clery TT Thaw LT ae ology] Colony TTTw [fae 1 Colas 1 1 Tee [IPT faa 1 Colon 1 1 Taw [laa 1 Gl rr, rrr or e 1 rrr r rr "="1 Gl 1 re de Gol rr ees [ree] ETI II cs I| el _----tt FFP | [tems |RoliqushodByiAftiaton| Time | Date | ShppedVis | RecovedByiAffiaton | Time | Date | IE-- a Tf eeATT rrr] rem CT lhe ewe copies | 1 1] 000475 ive ese ns ness ------ @oosvonr 1 PROTOCOL | i TELONGR ALCOHOL, EXPLORATORY wim 28-DAY ORAL TELORR ACRYLATE, TOXICITY PTH AD STUDY PrO8 (poise contrat) ! BY DAILY GAVAGE | | FOLLOVED BY A 1I4N12T8H-E0ARYATRECOVERY PERIOD : : . 1 | oOrSoSsausascrances Sn SHi5S,a --NESS, +ouaoss an0 s pares | page 3 of 16 - J 000476 11/00 `sa 1020 Tax sirsseseses -- _-- Ji-------------------- -- ere ------ TEIOER ASHUITEORR KRITE! IFRSIPS ] . TOC Fofet 24g T7022, T7032, T-6295 "PROTOCOL APPROVAL ] `STUDY DIRECTOR : Ir. 8.C.M. de Hoog | ' |i | sponsor: Date: 1 Septamboe 1698 MfR aervrinnE T,. CCaosnen,ToOnWs, PID . - OS dobyrdn 1777. ) . J ! page ze 000477  aves cas eis bax amssatases |I NoTox 5.v. --_-- ] TELOMER ALCOHOLITELOVER ACRYLATE/ /PFHS/PFOS @oosvonr NOTOX Project 242933 1 Prerace ] sponsor . 1 stu vomeer 1 Invotee Contact |} -- | | StudytDyirector SE EtrToAtxtcloEtogyrseartiviiccteHs N r3e L TIorYchoone nerenceor]c(gBeysa.tgSfe.rsvTeaiaackesss-t0e2 BiarbBarroacuNreelnssoent Operations 3TR EeMSieCpetnhtaenrs, (Bo8lh2d)31g5)1237R 232413-0-100s N07-.0004 oNERormpoEsakas.rivw.shtaotrritnagge3nbosch I3r. S35.C.M. ede Hnoog . 23 : | - rages - 000478 sos tes ses Pax sirasessses ---- Qos ast ] TELOMER ALCOHOL/TELOMER ACRYLATE/ /PFHS/PFOS NOTOX Project 242933 STUDY PLAN 1 Sere or reoweon 06 Gctober 1998 (nutes) ] 08 October 1998 (females) Start Recovery Bl008 sampring , 04 November 1998 (males) 06 November 1998 (females) 1 03 November 1998 (Matn groups, males) : 04 November 1998 (Main and Recovery groups 1 and 2, males) 33 November 1998 (ain areupe. Fen1oe) 06 November 1998 (Main and Recovery groups 1 and 2, females) . 18 November 1998 (Recovery groups 1, males) 20 November 1998 (Recovery groups 1, females) | UtGn4eDecocretmobeetrt1en558 (Recovery Sroupe 3. Temaits) 02 December 1998 (Recovery groups 2, males) pfaryaa7dsose :D1I28T97-E13S30 SSOceetprotbeeemrrberT1o9s91t89"98 (((RRReeecccooovvveeerrryyy ggSrrrooouvwpesse 113 aannnddd 322).) mFaortaetsd)e) . daayy 1i4t :{3108-3139 OOccttoobbeerr 1195998 ((RReeccoovveerryy gSrroouupmst 11 aanndd 23,. emamleeiss)e) : enndd oo5ff ttrrreoeasttmnaeentn :| 06B33-.R0064 NNooovvveemmebbeerrr 111909909808 (((RRReeiccoocvvaeerrnyy bdgrrrooouuvppess 111.namndda32.), mFaolmeisn)e) SST end of recovery SE : 19-20 smn November 1998 (micro (Recovery groups 31, ten females) end of recovery : 03-04 December 1998 (Recovery groups 2, females) ] Necropsy 803 NNoovveemmbaerr 11393988 ((hMaaiinn grroouutpes:, maalleess) 05 30086 November NNNooovvveeemmmbbbeeerrr 111199999999888 ((((MHRMaoeaiccinoonvveeggrrrrooyyuupppsssrr,,oouuppffasee'mmsaa1.l.leess`F))aebmeasi)ts) . &04 DDaecteammbmeerr 11999988 ((RReeccoovveerryy oSrroovupess 33., mFaetmeasi)ts) Drare Report | 26 Maren 1599 | <page 4 + 000479 10/09 98 10:28 PAX 3173041884 Norox 5.. Qoorsorr TELOMER ALCOHOL/TELOMER ACRYLATE! [PFHS/PFOS NOTOX Project 242933 I reer sosmuens ] ITAhteoEsps0oeancisoaoibrn1te"1bsesrfneFoesrrpenoanststliaobrnlteoofnfortchhteahresatcutcdeoyrmipslitenitceosnredseosrf ttoofheadlatletsettrenssitunbesstuiabfnscttehaenwycielclodantbfael.tattaken TroIEnh/aTsoneeraiffeectsatshse proceeditnogseoftIhTe bsteudaye. d by process naninnt) - 1 IdBpeantecthifiicnation TELOMER ALCOHOL (T-7023) 1 TE PeusrittySR ubstanS ce sto. rage . . SEcxtopanibdriiyltiitodynastein ventcie Stable 1% aqueous carboxymethyl .collulose: not indicated | Safety precautions GCRloeoravnlets0h,11a:n`gdongosgtalfeesitnaydnidcaftaecde mask to ensure personnal | Disposal Category | NeOmTsOrXiScUaBtSTiAoNnCE 83438 T(EdLaOtHaERwiAlCRYbLeATadEde(d77b0y26p)rotocol amendment) BDeastccrhiption 3 . ] PSTucteorasnibtdtiiytlsiiuotbnysstaunncdeerssttoorraaggee Stable B. 1; SExipibryilatdyatein vehicle 1% savesus carborymetiy cellulose: not fndteatad Corn 011: not indicated 1 oSatfueptoymtprceacta: eugtoiroyns GRleoavlecsh, ahgaoggSlaetsatyand face mask to ensure personnel i1 | Page s - 000480 - 10/00 "38 10:20 Fax aurssaissis EE Noro 3.3. I TELOMER ALCOHOL/TELOMER ACRYLATE/ /PFHS/PFOS @oosrorr NOTOX Project 242933 'NOTOX SUBSTANCE 83502 (data will be added by protocol amendment) DBaaPIustdreeeinrnttiyifpitciaotnion . (T-7022) TSetaatbilJiutbystaunncdeerstsotroargaege cESxotpnaidbriiytliiotdnyasteTn vantcle Stable 1C%oranquoefo:usnoctarbionxdyimcaattheydl cellulose: not ind{cated safety precautions 1 Disposal Category GBleaotveens'. ahgdoggslaefsetaynd face . mask to ensure personnel NOTOX SUBSTANCE 84436 (data will be added by protocol amendaent) ] DLedosnctri1pPt1icoanton pris (1-702) . BPTaoatsretintySubstance storage SCEatxnapdbiiirlyiiotdnyastuender storage Stable StaTiety Tn ventcte 1% aqueous carboxymethyl collutoss: not fndicated Safety precautions CGloorvneso,il:gagnootlesinadnidcaftaecde mask to ensure Paersonnel . Disposal Category health and safety 1 NOTOX SUBSTANCE 84141 (data will be added by protocol amendment) Identification PFOS (T-6295) ~ TDBPoueasrstticctrhyisputbisotnance storage Stability under storage coESneidaiTntsitoiynisteIn ventete Stable C1a%rnaqu1e1o:usnoctarbionxdyiscaattheydl cellulose: not indicated . Safety precautions Disposal Catagory GBleaotveens'. ah`gdogsgalfeestyand face mask to ensure personnel | Vehicle | RSattatnoiniailtey ftonrvavmeihciicele } 1SBp%eeacaisqfuoisncousgSrIacvaTirtbFyooxry5mk:ai5tT7hayn]toncsellpuolrotsoermoord Corn 011, at porox SSptoanbsio1rity over 4 hours will be determined by the . ponsc Page 6 - 000481 5 TELOMER ALCOHOLITELOMER ACRYLATE! PFHSIPFOS NOTOX Project 242533 TEST SUBSTANCE FORMULATION I rFooupras.aTRepLraiItoorh,ethF(.ovirdeo)bpienwtg.iitIegFenbeprcreeevspisataryreyso.FaSvadeTriiiyucsiTteIm:EeNnItn 4 F crerase comerrroms tts somperecurs 1 No cheatcal analysts of dose preparations will be performed. 1 PURPOSE AND RATIONALE ] e Thhmopae nraetue trheearnedSaapttuoripooeasveearrcoh2f0"othcirasycseiaxnpdloJorHaertnaotrriyyryFstoudldelyvseiwlnioglplmeonrbtaeallto(CsdoeemttpreorrucmnidngeevoefasnsdT)bsdsoosres Te Sal i Seve pment. TBThemiassnstsnetexunpdtoysushrhveoauldndu.r p1Trnh)oevmiadonetuaf}paacrrttouurtoeef, vuahsarnatdsileoilnneagclteodrbasausis.se ffotofr1tshteoaxiGpcaosostlsoigssilucebasltraonurcitese.k of J GUIDELINES | EETxhpiEosrTipnreontCtooucmtoiilotnve,ass orfevNiOewTeOdX aa4ndroadguraiardadbbyytthhoeADrutticchleAC1E4-ofnunActmiionnaary afd the TShuetdasttiundeys:procedures described In this protocol will be based on the following 1 1) EC Diractive 96/84/EEC, Amex IV.D, replacing EEC Directive 67/548/EEC, Part 8TRe: pMeesttheoddsbosfeor (2t8h.edaDvest)ermTionxaitciiotny oofrTaotxi.)citOyfiacnidalothJeorurHneaalltohf TEfhfeecEtusr;opeB.a7n: ] Communities No. L248, September 1996. v S2)talOETCaDxGiueirdteyliSnteudfyorinTeRsodteinntgs'o,f PChaarmifscaClasd,i.Gu2i7delJiunley 410979:5 "Repeated Dase 20-day VOTO Guntiey Absurine ond. I-- | RNBOraToOttXhaBeVl.T..TFaweTVd)aitai,rncihriervpaeonrttwhieatnhdfootlatlliowhiaanpgiespdioamnetnsase.rf'osr at Teast 10 years: written consent. <Page 7 - 000482 | . Lu/0s cas sez bax aureus Noro p.. ---- TELOWER ALCOHOLITELOVER ACRYLATE) [PFHSIPFOS NOTOX Project 242933 | Tote | TEST ee SYSTEM RspCraaagnutssDaanwlbeyytrnittacnCart1iicoDnalOR,guioduteblriende.s SaPsFthqeualtey. RFSeeeoccnaolTieem'sanMvgtiahldaaYroBesestnsuRylislvtieeprmaroS(uu0sl.0z.tieniEddP,An,onGF-eOprArm,eagnnyOaEnCtD.. EEC). 1 Age at Start of Treatnont unter or anions Approximately 6 weeks o4 mates, 84 fenses Randomtsation 1 . eGAtTeonTheeeas:sits"G3aatdnhatyaasTn]beaafnoigrmea.alsscrthuwediytdhcicsntoarrd3ti,g0g%byfoocfbootmdhpyeutseerx Heal "A Teatth Inspactian will be performed prior | iBeeCeomemeanrceemeInntaofdootdrexsttaaatentotfoheeanlstuhr:e that the Identification Earnark and tattoo | BALE LoCATION ereemmremeeeeriemmemimmrmsssn seen 1 | GSreounpt.tttcation ToSsubts.tance hNautmebser offomaantiemsals Amnailmea-sl fneummableerss] | 1ii3 MRRhaaeaiiccnnoo:vvageerrrrooyyuuspbgrroouupp 12 VVVTeeeehnntiddocccnlllseae Acsclooocnnnotttnrrroooollll 1 2fRecmoverymgro:up 1 iTolnomear Aelconhol 8$ FFIH se F$E 3 aa 1Sa3-i8 a1do9o5a7pi-8i1ao0mnr4 Bpzg miuamm )1 333[ReBRmaeciceonovveiarrryyougngrroouupp 21 TTTeeollooomnmeeerrr AAAccctrryyylllaaatttese :sFI 33 3 8 B gaugs41Fm8 0aa%ss | 44S 3 RRNaeaccioonvvR aagrrryyosgg, rroouupp 13 ers 3 3 i $3 3 f S9fg35em52 aioag5say 3 Recovery group 3 pris HI a] ,| 66 MRRaeeiccnoovveegrrryyougpgrroouwp 21 PPFFFrOO0SSS {((pZpooaslsiiittiivvee cccooonnntttrrrooolll))) 833 833 885135-.89085 1d17879n--118a941) !,| TSwetisoStnt}ssudbaansdyt".ances TTeollobmeetranAcleco$h3o30l2)(s"utbosbteancteas8t3e4d84a)L, aTedolsaem.erovAceryloafte30(Msaulbksatanbcoedy | PFHRSE ((suobsatannc:e 82434586) tHoO be tHesIteEd`paEtEhaa280d0os0e lIeNveNl oOfF S 10 mgS /kg bSody wRelght!/day. 000483 11/09 38 18:27 Fax surseassses sotox a.v. -- A ------ | TELOMER ALCOHOL/TELOMER ACRYLATE/ /PFHSIPFOS NOTOX Project 242933 ANDAL HUSBANDRY Loe | : Aceinorv-incrotonnrdmieetnitonweidthroopoeminwailthcoanpdpirtoixoinnsatbeeliyng15a.aitrempcehraantguesrepeorf h31our a3ndC cnodntraolled FTaiighattivaendhu+mi1d2ithyourosf 3d0a.r7k0%p.erLidagyh.ting will be 2 12 hours artificta) Fisorescent - GAWrcioctuohpmmwoiMdroaeutsiimonengshoffla3o-r4s.anAicmcallsinapteirsasetxionperporciaogde Treatnant under laboratory canditions. i1n3 asttailnelaestsssstdeaeyls bseufsopreendesdtarctageesf |1 DBFUirSeoAts, a"cOcueds:Tsurtnohosutta,ndBaerldgipuaml)l:stEeadchlabbaotreahtowriyllanibaealanadlfyested(ffroorm CnaurtfriilentQsualaintdy Contaiinants are aralysed on a regular basis. Results are examined and srenived. | Ferxeaentancecdesasndtaorcthaipv-ewda:ter. Cortificates of analysis (performed quarterly) are i TREATIENT || Method I | ome- vere ] Dose Tevel |Po FoOdrruaarliunfggaatvdaoigsoein,nsg.wusiilnlgbea psltaaciendlesosn astmeaelgnesttiocm?acshtitrurbesr. nsicnee ttitneyeaacrh aday,Te7nsday2s0 paoary,weesk.pMoaiun soreouphe anaaalgs"abreeydsoseetdhu.p Atoetshe dsaoysprvieotroes0 wneicrop0sy. ecialgchutl.ated weekly according to the latest body GGGrrrooouuuppp 231::: 33000 mmmgoa/krkkag bbb..www...///dddaaayyy (((VTTeeehllioocmmleeerr AACclorcnyotlnraootlle))) GGGrrrooouuuppp 546::: 31030 mmmiaa//rkkygg bbbooowww...///dddaaayyy ((PPFFOSS)) positive control) || I RECOVERY I... |, ouration RReeccoovveerryy Ggrroouupp 21:: aatt TTeoasstt 2148 ddaayyss | : - Page 9 - 000484 1/081/08 "vansa 18161:28 Pax saTanusesea _-- NoTOX 5.7.. Gover TELOMER ALCOHOLITELOMER ACRYLATE/. PFHSIPFOS NOTOX Project 242933 asemnrioncr---------------- ] Mortality / Viasiiity _ TDhlwasitccuoernetdaaarirtl,yi.swAh1niitckmheally1sstoschoonbwsoiicndogenreepdanionrn,aetdsitesrvtoarrnees,sisenwtiolrlinbe 1 AS1a1c1ribfeicerdecfoorrdedhusasanpererecaissoenlsy. aTshepotsisimbeleo.f death Clinteal signs 1 sT2uantddeenotndncatalla]yp,parndoiexgtiaanltaslt:eedloyncl4cienhioicumarmlsedsaihfartteeerrlvyadtoaisfiotnnegsr.wdiTolhs]eingbo i MTFio9nceorSdyoefmdp.t`oonnsset,wildlogrbaoeraencdordduardatainodngwrialdledbaoccording 1 %o'tixed scales (specified in the report). Body weights | TR2r5eecaaotnvmdeerny2t8.peprefrofdod : : on on days days 1, 1, 5, 5, 8, 8, 12, 12, 15, 14, 19, 19, 22, 22, 25%and 28. | Food consumption Weekly. . | Water consumption hSSutebujdeyacvteainnvtdeaofapq`apuraansitusisatplaetcwitveiedltarsbeesaemtsamsiemnnetnttairneielndattredodudruiecnfegfdectithn.e CLINICAL LABORATORY INVESTIGATIONS (Main and Recovery group animals) + ` ] BQ5r11o03l00idpaiasmna"immpalilezsss,ewdaiilnaldtofbloeyrpcrRoieloclroevctetoreydpagurnsodtuobprora1ntiigahmntalexsoatmahilersnoatainatoasnstthfhoeersetMnaad,inobfaetnthdweeRenetcr7oe.va3etr0myenatnd ] FBPaTorctiorodod-:osrambTpihlteianlagn,stiabnauultss wwoiafltlear11bewMiTalali3n5beaednpgrooRvveeicrdonevideg.rhytBir(cawotidtsh/sseaaxmm/paglrxeoisumpwuimlalnodfbe2c0oldrlhaeowcuntresd)frbfoenmfttoohree fSourbesclportetpianrgedfewsittsh (E1D.0TAm1f)or anhademuanttorleoagtiecdaltubpearsamfeotrers1.in(i0c.a6l alb)i,scwhietmhistcriytrate Paraneters (>2.0 a1): i ! - Page 10 - 000485 -_ a 11/09 '98 18:28 FAX 31736418543 NOTOX B.V. 1 TELOMER ALCOHOL/TELOMER ACRYLATE [PFHSIPFOS @o13/017 HOTOX Project 242933 HAEMATOLOGY 1 TEhDeTAfoal3lo`awninagntihaceomaagtuollaongty,paursaimnegtetrhse wIinlsltrubmeendtester1miisnteedd:from blood prepared with 1 Parameter vite Instrumentatfon Erythrocyte count 0m Sysmex K-1000 1 [rR sa0/1 _ Sysmex K-1000 Haematocrit m Sysmex K-1000 MVeaalnunecorpuscular nl Sysmex K-1000, Mean corpuscular foot Sysmex K-1000 | haemoglobin MReaasnnogcloorbpiunscucloanrcen- mall Sysmex K-1000 . | tration Platelet count an Sysmex K-1000 wiReddthcell distribution * Sysmex K-1000 . 1 TDCooiutfnaftle.relnetuicaolcytTeeuccoaucnytte G(/r1el) [ry Sysmex -- K-1000 3 ] The foTiowing nasmatology.paramatars x11) be determined from blond proparad with citrate as an ant{-coagulant, using the instruments Tisted: ] Parameter tne Instrumentation Prothronbin tine sec } Ptairet1aT thromboplastin soc Sysmex CA-5000 Sysmex CA-5000 | Page 11 - 000486 11/00 tas 10:20 FAT 31736418843 1 _-- NoTox B.. -- 11 TELOMER ALCOHOLITELOMER ACRYLATE/ IPFHSIPFOS NOTOX Project 242983 I cmon swomasmy 1 Tshaempfloesllouwsiinngg tchleiniicnasltrbuimoecnhtesmilsitsrtyed:parameters will be determined from serum Tetforaese ea : ] Afsepfaarsteate aminotrans- 1 BCihleitreusbtionr,en,totsaolta1 .J Trcirgelaytcierniedes Glucose | urea Protein, total set pkat/1 morn pmol/1 wpmaool/1 ano1/1 nmol} on Epes selective smalver 5080 (Espendor) Epos selective analyser 5060 (Eppendorf) EEppoess sseelleeccttitviea aannaallyysseerr 53006600 ((Eeppppeennddoorrft)) EEppooss sseslTeeccttiivvee aannaallyysseerr 55006600 ((EEppppeannddoarrft)) Epos selective analyser 5060 (Eppendorf) Epos selective analyser 5060 (Espencort) Epos selective analyser 5060 (Eppendorf) 1 .1 1 | | J | en PAriobtuemitnn,argolmoubtuilninratte 1sn Alkaline phosphatase pkat/l Pnottaarsstiduem : mot mmo1/1 Ceanlocsipuhmorus J, mmo1/1 tse ve poten Epon CCaaltceuultaettitoonn [[PArTohtuemitnn/tGoltaablut-n]Albumin] Epos selective analyser 5060 (Eppendor) EFIX ---- 5055 Flame Photometer (Eppendorf) EEpFoIsX 5s0e5l5ecFtliavmeeanPahloytsoemrete5r060(Ep(pEepnpdeonrdfo)rf) page 12 - 000487 sa a awe Fi saranenssis sorot a.5. SW 1 TELOMER ALCOHOL/TELOMER ACRYLATE! IPFHS/PFOS NOTOX Project 242933 I 1 wuRIrNsYsSIsS (cRueccoovverryygsroruopeantnetatse0o0m) Uerrionesssmemgmtees nwiiTn]boeeccotolactcad ouernighs aC pproximateL tlhye 1f6olblroew)inrgosmenaad1u)te: SpBrIoUdOoNss sacment porto on days 7, 16 and at the ond of ereataent S<upurrartttoanvggtehtethdeheeunsrdsaiamnompefplitiihnwaegTgrbpepeeerciodT orvadenriyaa mnptaealraislosdIx,wITi1p,lri0ob8roSdtHoeiRpnC`rdIsicLvsheEeedaYdr,ueolCdfeEdfaonFtuoetdc2irn0obgpu'stCsy.vTaaettteaNrpOoTwtOiiXlolnuntbce]age. I To penser | | AALapteals sua rvivinegh ta oC the sS ad of tShescbsS arvatiR Eon eperiS oSdhanSdhR an1)poertbund |Trio Tes wih oe recorded. sRo exEsanpLuiaAtionT4 blIood NusGe (1-2 HAT) fSor sRerumEcolleRction wil) be | Snr eres m campos of n the fallewing tdissmues R and orgAans wiS ll bs cSovlEecteSd frEom aTf animals ;1 fLgfoarEatrnetsttctaatn marks .. ] Lo ea CRaeenre, EE o8ec parvo and Hardardan land | E[TeeaeXs Re nee i | fEiEEepune with rormrtn ` , Lyunngahhnnoadcees-mandibular.mesenteric 1 Rae. | a; ge 1s + 000.488 11/08 ten 10:30 PAT o17asiLenes NoTox 8.3. @oissonr fr emmearer ----------m---- 1 TELOVER ALCOHOLITELOWER ACRYLATE/ [PFHSIPFOS NOTOX Project 242983 Fo wera : PEPReleyecesrtrto'amsttepaaotlcahnnes ESivary glands (jejunum, 4leum) + mandibular if detectable . Snir * SSeomnianlalcvoersdic-lseesrvical, midthoractc, Tusbar BE Spleen vith bone marrow ] STtooemach fTUrriaicah,reya including badder parathyrotd }. . URrSerues,ss t0stons I| TTherfolglowinngnoarganaweEieghtSsend(aaundtetderdmaiynaolf bnoedcryopwseyi!ght) will be recorded from the | AHAderaNerntal glands Kidneys . 1 SuFSaoeoretienes 3. . BShoet'hstaubdsyolurteeporatn.d relative (% bady welght) organ weight deta ~ will be fncluded in ] FLFraovemeraos1wmeanLtDeaGalrs surTvuinveinwgii}untEislTrtohgeonschiendullseodponnteacnreo/pisyy.a:tLivleerastsa1mplgersamwiolflthbee | Orel 0a Noo nt 11 further analysts. || | i I Pa=ge 14 - 000489 ' 11/09 "98 -_ 16:30 FAX 31736418543 NOTOX B.V. ] TELOVER ALCOHOL/TELOWER ACRYLATE/ /PFHSIPFOS @o17/017 NOTOX Project 242933 1 HISTOTECHNOLOGY AT] organ and tissue samples, as defined under Histopathology (following), will 1 Wbeithprohcaeesmsaetdo,kyieimnbedadneddeoasnidn.cuStpeactiaalthsitcakinnesswsilolf b2e-4umsiecdroatmettehresdiansdcresttiaoinnedof `the pathologist. ] HISTOPATHOLOGY ST1des of all underlined organs and tissues (see under Necropsy) collected at ] : dtghoresoessscghrleoedusuptlsoenwdshioscafhcraildlfiiecdaensifpmroaonltmsana(lealolulasnldiyomsaeolrsg,wreouarpses)wteelwrlimlilnaast-beefdreoixmnaanlielnxetradenmibimysa,lasanodf aallll I. pathologist. AT1 abnormalities will be described and included in the report. | 1 -- Se TATIeSTIeCAL rAeN-- mALYSIS ----rt eeset eS pee The following statistical methods will be used to analyse the data: ] If the variables can be assumed to follow a normal distribution, the Dunnett- 1 ftoerstth(emacnoym-ptaor-iosnoent-otfestth)e tbarseeadtedongaroupposoleadndvathreianccoentreosltimgartouepwsilflorbeeaacphplsiexe.d The Steel-test (many-to-one rank test) will be applied instead of the Dunnett. ] test if the data can not be assumed to follow a norma) distribution. A11 tests will be two-sided and in all cases p < 0.05 will be accepted as the Towest Tevel of significance. oh tn ] Additional methods of statistical analysis may be used at the discretion of the Study Director. The methods and the results will be described in the report. | - .M. Dunnett A Multiple Comparison Procedure for Comparing Several Treatments with a Control, J. Amer. Stat. Assoc. 50, 1096-1121 (1955). : J - R.G. Miller Simultaneous Statistical Inference, Springer Verlag, New York (1981). 000490 ] 2 | ] Page 15 - - 1 -- m-sm-mmf TELOER ALCOHOLITELOMER ACRYLATE! [PFHSIPFOS J DISTRIBUTION This protocol will be distributed as follows: I rem SULT erat ion 1 Copy: 1 1 Copy: ] 1 Copy: Varagonens Clinical Pathology MNecropsy/Histotechnique Sponsor ] . I | . | | HOTOX-Project 242933 : hi : 2. 000491 Co 1 Met mmmteons | STF HIS 325/03 SPECIMEN DISPATCH LIST 1 NOTOX PROJECT: _24i2933 TEST SUBSTANCE: 83502, 838448445,6, 836449144,1 SPECIES: _RAT. SIGNATURE/OATE STUDY DIRECTOR: Slmeen-- | | 28Yancy 120 1 ] 1 * 1 ] To: Name and adress company: A3ttMn.EnvKirriosnmHeanntsaeln Technology and Safety Services 5w3i5tdBiunsgh A2v3e6nu0e0 St. Paul, MN 55133-3331 Weis Honsen) er UtSaA. 6 S 51 TCE oo | 5C14o38i64n8T-0CasCheeers,)ax es oo | 6513332578 (Poul Lieclr), [T [roo ms[cmp [m eros[orows s[orp| vue |mare sys Jiro fovoi o 1315 29-31 s1-63 [77-79 53-95 |i Afneimmaallesnumbers 19079--110171 + |[112153-2122734 |[114219--1143394 [[115475--1155954 [[116723--1277514 [[117879--110971 + | usasmeplresof 1iver 1 ,i "Also enclosed are : [[b|] 1] CCSootpphyieeysorfoefPnrihotitsosctooll/oAgnyenrdasvendtasta Co 2 [ 1 Necropsy data transfer file 1 i oo | | DISPATCH: .. signe: WTR nate: 99: 17RD... | PLEASE SIGN AND RETURN THIS FORM AS SOON AS POSSIBLE AFTER RECEIPT: I: covemvrOssst.aA.wClrimuon..e.3.0 outer... 02003/99. oc.Fb3 1950 1 660492 | LisaA.Clemen ANIONS 1 Evo Tp ay A02/06/9904:20PM Sans a | fr. Ar 1 To ERs Ki HansanlUSCoporeGSSMMCarUpoSrta 3 Sbjct: NOTOX242Sam6 pl R0ece3ipt 1 OTencan0eid2v/e0d3ff/ro9ozz9eawenroencdeiiyvkeod and ave roszer at 20. 168ratliversfrom NOTOX242833(TOX120, beenstoredinFr 9 at-20 + W1220). 10C. The s e sam ple s w ere Usa SAMPLES REQI4 VUEREIFIDED OYBGcbafy 1 | 1| | 3. J . ] Co ] . | | | | . 000493 Seuty 8Evonmaensetarcah8l | Ho0 ambbaekesinevetoaig 3n b ] FRo e73s418s5.6 | 3aMttnE.nviKrroinsmeHnatnaslenTechnology and Safety Services 9B3u5ildBiunsgh A2v-e3n6u-e09 . 1 St. Paul, MN 55133-3331 Use . . a: a DReaf.te:: 2K9I-aMM%9 w: 1 Subject: NOTOX Test Substance No. 83484, 83494, 83502, 84456, 84141 1 oeres, | : OfnromreNqOuTeOsXt opfroMjresc,t S2.429d3e3.Hoog herewith I send the liver samples (total 168) | WNiOtThOXkiB.nVd.regards, . . 1 MTaers{tgtStuebstdaencKeinkOeflfdiecrer == Straaijer ~ Ee enclosure: a.n. Liver samples | . { 000494 i Co ssa : 1 NOTOXProject #242933 me slsms ed ow isecells Feb4,1989 dnc. : Afthesreecaodlilnegcttihoenpraotteoscoalr,e owottcsomtehce,cpollleescsteiocnadlalmt eoane1a-c1h6c5o-Tn7a8l-eSr56.8S.e belowfo dats. | Regards,LisaA.Clemen : [3 1 3) jem Bo me 1 . Sup1FRls GroTop C71o0l38lDeatAoddned SamW0 poles 1Gro1op C7r1oo0l4ml8ee8DcatAidodend . `43 11 r71i0e0s8 . m ns 12 1T0oso ] v 22 r7iuvemms w2o 22 111100m v2 71mm W370 1 23 0 32 33 r7110v0m0s88 1w92w 33 171120045s8 14 now - : 3 3 1m 1 4 110m . a4 17mmmm m ms s 111100048 . J sEtR 4 Tims ns 56 71110008 | s 6 s5 rruusss 1BL 066 1111000 a& 55 1111ms | 2si 66 uummmmm B 6 Tim . | us tums 4 1 000495 | pre 10X12LiveSpi Ree209 `Sawpmeples rn Cito) Group Collection Dats SSammpsles GrGooneup Cine] (Collection Date. SSamBpEles GrOoT up ime Collection Date: ] G2~o2 oonnro1 or m1omo1m03me9ee8mmomoowd86 5 of 1ENdo10mE3Rm9RR8 | || ~1OMWO3SWEW0E O3353S ee1m105mmm/98 Son mem om od ka |W 3 ime | Sw 3 80001o1m m1r 0m45m8mmmlxs n op5oc 1WWm1/E0Em4R98 | S 3N |W633 e d11/e06m98 ] WRBo1Er cmnmmces IA5lom3cF osoo pnmommJ|I Sa WE 3 mvaneces 3 Bop wo20 ~8 2 om mss 1103/98 30 wn 6 \2 6 mm 1s 11/0398 | 3"es ds 14 4 hee toss 110598 1 IX ~ZgZ2o0ooroo2 23 1ooo1m/mm0e3ee5)8 | ~38NY4 fC6feH1mh1/aEa0a8Rm98 || W3~|W4Wmg f4L"4 e1mmm1e05eee98 203 ume wo WR| U4 me | Booms 26 2 a2 11898 11/1898 | fhm 90 6 "1 6 111898 11898 | WL N54. 4 ss 4 me 112008 112098 | ~oTDS3oo00p52 12omtm/i0em0/em9mes8 mmGo3S94 0006 1mdeW20m2mmm9m8 | | SWSW5N8eSLs4 1200498 eeme ness | 6Bog3 musmmmwo L1 EfeRss | g3e 55 wmseees | ~38 3 100498 N02 1 11/0698 166 5 Toes 1 ] ~39 WW Woooyp ooummmo | o 3|NeEfwamm||| ~40 3 110498 3 110498 Mos 1 04 i 11/06/98 11/06/98 ~167 aWWemm"168 53535 1106798 hamawew 1100698 4W5 op3 omm|ow 120298 N09 oil RRR 12/0498 Ams 5 me 12/0498 ] . WWw7ooo3 oLd rC1omm2m8um mmodan oLooDMeE1m2/m0Rm498 || O|aWrGWms 5 12h0ne4em9eee8 | | S00 hmm <$TS3 oo4ou4 mo1u1m/mm0e4mm9)8 die 2 oem oo7w u2orncooc1mm10Ee6e9|8 | eo oe vss WMlGSWWL f6fhm1d1/ee06e/w98 Bog mem oumooER lS em |poswFSSo8fLp4domm 1uoe1mm8]9me8mo"ooWamcnzooouo2omoozom1o1mmE70ma5R]8 | SoWWWsmm ff56ooE1hna12o0Rwe9m8 000496 : 4 5 em -- ER CC0, . $ 23 ee ee oemmPa" --_ 83 oC|SEETAbmmBroAEa iWSAEFsTEETRYIR NRGT3 ARTA ST PT os vemTooENBOScH mis 8251 0, a |By > . Son? ootLTTE A- HARAMAMAN GD_840494663 WW REESE STR Jove TEO d SW eniMaEreeTanal TeomaSoy | 34 AE G5Su, k esiie: PpoiTeElCLRGeCTnsRAToolsOEs tiss oTerosn rip2co of| nT 15 Toe c ath oa o |\|akgt lho:Go. Go} EEE XPRESS] a > { "3 dag ee -- Tl 5000+ | =m ee, oouasoony%3 hee oe Brn a ! consooos Bjf EO OESES BB(EEEf= E Om.Omee n | e E J 2 oT Zo] J-- elo hESai fea de A "7% = = 7 DILUTIONS SUMMARY SptH,EEweTet] oldspd ------ SVtudyu: hZe4p82t ee o oLof5oH re y a e MSoaltveipUsT7NN--umb--e2rf:,--7C4u--7e5'--225--7-------- 2 re eer (iergz |dXPT T e T T T S (022 ee] ag) HT rT rT v7 --H Zs 67. -- HTT T1711 rr ae ar -- HT HT ee | j2r__| dT TT rT 257. ler -- Hr 1 27m 18. : FN ee rT rT cor a SS LI r TT ICS SO a0 3 vr e rr jE -- HSRE wMounllosts E commert t : : w-#7z Stay: TT 7 7DILUTIONSSUMMARY SHEET hai a ghey sn hsp ww aeea--r--e --7--A--To--n s--am--p ---- 2 T soees|_I|xe [ T TT e TT] 3 T 1 pas ome |__| H I 1 F 1 T a7 re || T Lr 71 T 1 r 1 er er rr Tr T Tr J J r TTTT TTT ---- ee TTT1 J = L H T T T 1 I TTT : te rtet oetr 1 DILUTIONS SUMMARY SHEET Study:To Rs tg2) [rorwir Solvelt/nTNA Number: Leiet?r o-w00s7b 8 gS wolwrer or peefp Je Ji Tr Tr Jommms 1] | [1 1 | 1 1TTT] lr] 0rr] oe rT lope 1 1 rT oe 1 TT 1 erm TT TTT1 Ve|[T T T TT 1 Vary[LT TT 1 mle [oc 1 p( ee| 1 1111 1] me 1 [1[TT "1 le| TT 111 "| oe TC [TTT 1 ee | TOUT 1 T1111| pe FT oe TTT TT 1 oer| 0 11 lor Tr et----t-- [1 e------t 1 | | 1 T 1 1 | fim eh, ven et DILUTIONS SUMMARY SHEET BinDaa: oh 1" St14 71.0% Ean ie ey eg [ri emwwwmes 3 pte per LL 3S 7] rrr g fed rT for Cr (or (A 1 E11] i |r 1 wl |rrr rp er| 0 rrr (za || TTT rrr rrr 1rrr r r rrr rr [on | 1 r-- 11 or | (7 T= 7 1 [aor |(TTF ee 071 FFFF lWoata0]v [17520500+,+1 p2t. SpJlB:--gV1ipVapva1 ITE1 PT 1 1 "1 1 1 | 125 7 gut Teg SigsMel DILUTIONS SUMMARY SHEET a st BALI CL Box#:99-0C7Av Rl]a---- -- ordoopten [FETTER TEE fn Matrix/Timepoint:F Liver Te Je Te fv Josew N |3 -,--- Me. 3 rrr [an 1T1111 loge VT 1 T rT [4a (Tr (or | TT rT 1 [3 | [1[T1111 "| lor| [1 TFTT1711 1 Jo | 11 Gra [1 111711 [oon| [1[TF 11T 1T 1 1 [wot 17 [111111 [amd ca | |x |1- [ 1 1 1 [a0 0 111 | 11 1 fad| [0-1FT oe v7 TT 111 1 1 [ems | | | =1 1 11 1 fo | 1 TTT [on|__| F111 ey 1 LvLt 1 TT 1 T 1 | HET il (:25 Ll = HOuL Bnwot Sample PEG + -= DILUTIONS SUMMARY SHEET Study: 705-20 R DilutionDate/Analyst: 0c) 7, 547 Box#: 77-05 AxG `Solvent/TNNomber: 01, s-A-3437 Extraction Date/Analyst: 4+V7, 0,08,528 p, Matrix/Timepoint: fat Low ' I. [meor mde epiten [7m 7 JE m Jee fT e sr ] fomess | 2 47 63 Le 2 rrr rrr rrr rrr rrr ---- rr rrr rr 1 rr+r rr+"71 Trrrr1 | EE EE rrr rrrrr rrr ------ -- -- rr rr rr r rr | rer rr rrrrr r tr rr |} rrrr rr r rrrr rr r rr tr +r 1 1 r 11 1] rr Ca -- 1 E1 g1 1 1 1 1 "1 T 1 1 1 DILUTIONSSUMMARYSHEET hr re Stody:Tox- 150 . BDiolxukt:ion9D9a.te0/0An0a4ly4sts: 57-9 /sce E`xStolrvaecntti/oTnNDNautme/bAenral:ys1t:01H-[47/02-A0"v2-530o6.. 387-31 Matrix/Timepol2aat.: Give or fo Toe Te Jr fs TaeTTT Jr Je Je TT Tr om | Jenne | 5 8 r r r 1T rr r r 1 1 I ~= ~] T rr rr r rr r r er er re r rr rr 1 r r r r rr Es a mm meme me rrr= rrr --rrr rrr rer rrr 1 rz= rrr| -- 7 SSA SN EH HA A rr e= r r r r E tt t[++t 1 1 en 10of5Sam4 ple 100uL Muol (597775) : olFH DILUTIONS SUMMARYSHEET STOt OXX- r 0we 9-H gremumn. t)1]A7 AonDpores Box#:99-0bgR MatraTimepolnt: 01 fey | Gvple-made em wemow ees [oe fp gam an o1r rr 1 r 8 r--18 gor TT [rT okT eww -- rt -- rr r r 1rrr eg ow | 1 C1 1 | --1 1 1 C1 [| eon bow (1 1 TTT --1 1 1| 1 oi Big Tt r r r r rr 1 r rr rr r G7 os T PO I 1 NS 0 FOM 1 S 1N 1 1 FN | es 1 re rr es =re rr Tr r -- = -- rrt 1F t - r 1 1 | or D100=0 aul sample + 1000 ul winthavrol rn sn te ee DILUTIONS SUMMARY SHEET . DStuidy: aoTdOr/e2a0mt: 09/49 5 SHH Box: oy990g ASE. SSoolvematrT Nambeerr: MIedH [h/ TA-Hp 3! y MateixTiZmefeLipveor l/faritng I ---- [re rT Tr] M_4 omer rrr rrT11 1[1 2 |g wey TT |[C11 bowey rr wey 10 | 1] booT wweery (| r r T ] ] rrrrr rrrrrrrrrr rrr rrr rrrrrr rrr rrr rr rr r rrr rrrrr rrr r -- + rr r Tr ALf DI0= 100.4L Sample + 900L. ethan]. | +" Sample weights/Volumes . | or H443n /72 re . ExymentNb: rTOXI120 | Se FampelevMan treix:rfs1# TLaovpei / TNootetbanoedPoagnke: : [= [Emre] we | dia = Cr zl 25| 1 le Jeune zs wo lpgealede| wa lpggarlzq | mo 1 wo po hoa ]hwo io fimo hoo me howe pgade ametd i (esd 32 pera | es 179507 [v3 Jo7o7| wv ap Tae pgm | %3 /gsg3| 3 ps9 eg | | |] ||] | | || |] | | | ||] ||] a we caso ewsw[3 a c I [ L 7| | : J uo we Tes |os Town |oy | | | ]hvZio ea-- ---- | Finals pec T[ oep sma lgz e bd) ) Dro | oT | | S1)eramptle7r SAoLmopeLaie, STL GIn rFACTo-1e1r-,,S0 THeHp ,12:1(rl; s rreeep, t ase | 5 at srgs ll ALE 2 wrAH : I romp Teron pa } Vpn 000507 maeiot__ Sampleweights/Volumies | pASNreogeeDmastoae:tus4e/f1H5P5p9FssxaP-t | Tost . fESoetmupdymseNpnumtvbeiur:ombTnedOr K/20 . Ft avn Number bwa ---- |bva -- sogsslsg | logs/d 48 | | | ] ve poys [39 | | hee lpgegs|4e | | vo \gsasy gg |] 1 \ wvee osz pw l ss | ) ios|| f | e ww gees [37 games 4s 1] |] o , e | bow aezlo3| lpgss 78| | we fw gga HW.q | geo is. | | | b | v o o Zwzzlz z.l g | | | s ] | ] wo pssm Ze | | oo wmpizz TL] |i os | DZE Ze" rey | Revenue | . FormApprovedbyDate: WignvosmeSeaioas 000508 Perle `Sample weights/Volumies - | Rpearfepaa;w1/7~9rrdSReI . SMaemtphloedMRaetvriisxio:n:2)~AFTL=io/e7/-/10 1 "TargetAnalyte(s): StEuqduypNmuemsbteur:mbTrs0/X20 `FNiontaelbSooolkvseaastdTNPaNgeo:mber: | pmo ao 1pmo 1 p9s37 |5 Tpepy| vc [pews| pe | 1 | |] | 1 1 oe opmemgeb | osv 1lowes . lowes Toes| y |[1 Toys| ga ||| f1ees pgol|wo | mes lwo Tove|49 | 1 | Tiemy |wr|| 1 owes Taop77 | wa | | | wes loam Bee| | | | wes Tags |gy. | 1 mes Troewe |ws| | wes (waar| zi | | a| es oa%e |32 | | fms Tom9e0| so ||| [mes |mes lo9930| go Toump| ay | | | |[|] T ees imo| sy| | ][wes faves Topo |wy Tomgey| my ||| [1] foe To9765| 49 ||]. imes [ogms|a9 | | | ]lowSesr -[joerg|wa | | | J | mate Revenue | ign VahmeSesios 000509 Ptof Sampleweights/Volumes PrepDatel: 4/1729 BES 0 EEE | sAnaamlpylsetMs)a:teiR x: u=fe )e[pw-w eSRnP? !FE E E ET 1 TargetAnalyte: Study Number: 70X20 `ENquoiptmeentbsNnuodmPboaegrke:: ee pga 42 | | | | wes looms 44 | 1 1 wos (logeo |S09 | | | 1bwos J loesg]lsz | | 2 aadAgs || pes (4s | TT 1 p1 os {ror | sor || | bios (Jes les | | rrrr] 1 1 1 rr 1 ] rr] 1 1 1 1 11 | rr 1 1 11 | rT 1 | 1 1 1r 11 . ] pr 1 = 1 1 rr 1 1 1 i 11 1 1 1 err TL ] I Notes: | pinisivmp | - Form Apros Weght Volume Shct120s 000510 Pagelof | Extraction Worksheet ETS-8-4.0 1 | "Study #727 BMoaxti J20 | Surrogate S10 FCMix FCM aapcpnraolx/.so ppppmm||apapcruoslx.0.5 ppppmm|| apacprraolx. Sppppmm|| FCMix aapcptraolx. SOppppmm|| Diced IniStiiadlesfror 1 $I ad-2Y | Eo A 4 ZSall-1 | # Badr]| Comments CvaAygHamr man os) | oT TT u T kA) | (pepe C CZ is e 21 T11 | Tp odT7 T 111 Cia ed 111 | C Tdf n Twp Con amay -- y TT11 ] a e n r g y e aed gr 1 wf Meeerr -- 1 | r r rr e 1 GM Gareger r ---- -- r r rerr 1 hw g er r r---- T or-- e-- | 7 I -- ii Gg er we r er---- py 1] (Bk ZI)Lun SudG20[1-32a smown= 2:0 wl Bl73ell) Detalles) | 1 SCOTNCObrSid eFeeldS ldtizl ARI| | ] aZise | eee 1 1 Po stmen _ aso Trew FPuronNitogenEvsporsior vodorvwoessE[vi0porsorw_l______m_e__aToempgemy[ wes | |_| | Te = | [SFi4'irM.oSrg/2uMa5sStiDe7n/SgJasYpno_pdC-amoBr.nd0t:M.sSCyphiSenkckeeIsdw:uisS_MpJesipdO.ksS_ezauduuLpDolffe_/ip lu5e(rlJ)oosfhpeaLo/mSzz_m5S--l9mpw(pt.oC$ms8oas0mntp7d.l)eC=vh/aelc(=-- k21s2u)-- steodasll7a) smaemfmpoalretsra,fiixsnataaslnfdcoaorrndsscu,deSnanctuerravleta.iorofns O MFrID1= Spulle 3016] ) M524102-Spulle e116] 5317593 Tpeke /1m6) Extraction of PFOS from Serum 000511 `Extraction Worksheet ETS-8-4.0 Study #70X-120 Surrogate Std FC-Mix FC-Mix FCMix Date and Box #991 AE Matrix RaLtif | approx. acualjo0 ppm ppm | | approx.0.5ppm| actual ppm| approx.Sppm | sctual ppm | appr5o0pxp.m actual ppm | InitSiua.lsforor || ajl= + wpeegdr[ --1 A --e 1 1 ee ------ Ty i 62 S | CS BT. Gomer Bemea-- (rT (rT | BGoammgea s( (T rT T 1 | | 1 ow os rT ag Gamer + me k Bower rT oT . rT Mme rr | mg lamer1 eg ---- rT 11 rr 1 TT Mage ---- mer 1rT rT 1 | owed |v --- 1J | Fo ALT Ty Ses PIS wmowi= 7.0 mld,= 0JkDIN ] Nomis dleJor | E| [Pee Imior CIMAAT. Sa Joop SARJPWW J)a| [Pipe Talof02NpCOyOIM NaHCO bole SudPoplipe I | ] [Dipsmlormeiybibuiener______ TMohziip |_| Femaed) | tenn J I | (waiol Tomatometer | Fritmewmaee------vo--ws--7-- 0 --@----ToAR Porm || | C OM'i MSS/r MDJSDe ID//1TTE-_CCaEpoonnitb.ke CheeckSs:h HSe pedio EkelT,aMpeSHrisvp DaS xs- i spp+SpLamsLnte .de CGh(Me7c7E0k]s ,evdSasasmTee fpmoreaIainGsdf"oCarosna,cdnecnl tturreavteiioo1nf3M 61 EncOiShnmSoenn 000512 | ] `Extraction Worksheet ETS-8-4.0 Sy FINI | Surogate S16 TCHR TCM FM ued | Box # 99-068 ALE Matrix aF-Liver | approx. ppm | approx. 0.5 ppm | approx. Sppm | actual]00 ppm | actual ppm| actual ppm approx. 50 ppm | actual ppm. Initials for Std. or #9904) 372% 4 4 # Comments 1 Emel | sql1 omgy-- (1 - | Tradl 1 TT "1 loam gr- | ey r 1 r Tr T eyTr ] awwreggyr | - - T r 11 oi ey rr 1 s Gr eeee 11 r -1 1111 mes 1 1rT | Bade 1 rT | iommeer( | r _- | ---T T --- 1 &1} [Shadynumberwhere theongal worheetBlocaied. FokBAGSZor SeiP0A-5-20 _ wmowi= LO widennk,=dJo0iml| p N Po om me s Vow 7.0 ow FelaJ_P____|| i [Pipi (miof03M BAGH. Selospu 7-2 SAE 7/777 | [Fipefic2ml07025NazCOTOIMNaHCO bufler_SdFor50 ~ | | ] [DispenseSaloTmemytrbgieher eA ZZyo | ewe | (Cmhmmnme meve CowfmewetZp | 1 | } [Removesioldmworofom FutonNiroges Eviporsior io drvness_Eapomiore_______Tempenims |__| I Aste ExoensFaF uhomSm I ORin=S)he SHE, AsaTnii-Spke wl , WSIS -Spike 131 61 SRE fmShe Spbed ofa ama OEE to wien J1 a . 250 ppmd. MShS ked/ us1eM 0d sS aaLmpoD lfda) Laplpam STCI.GC0o)nt/.-CLhleoc=k1su)s0ed3s1amsaempmlaetsr,ixsaasfnodrrs,tdcnudrvbei.snks | 000513 | Extraction Worksheet ETS-8-4.0 EA = lm | me| me 1 | mET 59100-3.0% T Zeal Comimls I Study #_TOK-120 Box . `SurrogateStd FC-Mix FC-Mix FC-Mix Date and approx. ppm |approx. 0.5ppm| approx. Sppm | approx. SOppm | [Initialsfor | Es | lgeA Mae-- --- -- 1 ---- 1--T -- P fBm eme se er T 1 TT bos 66-1 1 1 OM r e r 7 Gamage +r T ] srr TT Opri-das 1 Mogergep 1 77 \oikke C1------1---7"1 1 1 Bbepgy rr Uitgrpatroreemsp|1 1- - 0TT7 --1 --=7 ""1 1T7 1 1 1 1 pre [Fo nde 83 1 Ge nl, USC abHue MBEgatdin= 1 1 || i ' [=otro d 10 Vid [oC OFSima MIeRewed iatcamels. SAE fi9/72 --- | clifbigrly= | - >FT _|,- | t ee p 1 g tT gm ----r r 1 Sppdee----1 r 1 1 T 1 e eialvoichet load, FE W-C00 we 70 1| wlAmik OIRO Note btw | 1 [Pipe Tmlof03M BAGUIO. Sa ap-7-2 1 O [Pipr e 2ma loF0m 23NazCOJOTMNaiCOybuler__SWd_aFoetdzoo0 r SPHJPWW 7/j7/77) 1 | I seamen era tints Ceormmmnas-- Comhewest JW | | FRFemoonvNeistiogoelnuEvmaoporrsoiforotomdmryenmeessrEvaporor Tempe 1 | |__| | MA-- ddomeeaner--va-- wme 10 -- m-- wag ----1 --| | [F0MSi.So2M0mwS)iDenIgaIT p=oCBmon.DtM. rCShnMeccsSktsDw:ui1Sshp0eiadk0esdd"auLmopmJltOleei@eu)rLmL oyosfspo-31S2m0C l__o_pv.powmComnt.pstl7 de(Cvh4aelc9kQ1s]0 u-ts/eLodos=l]a)smae0 TmpomlraetsarF,isixnaaa7 lnfcdoonrsscet,N ndstnrc) Zaudrtvieso.nkosf MSH Mo) spike SH , Malo-usps ike WH 1, MS3IMS03 Spike 1341 1 ExmolPcFOSifoomSnem 000514 nvm B =Da HEi.,B HeEErie E Ru FiRsEe n |}| DS Mseeemim nrmuEeE EoIeiEs EE = TEE|e =TLe| RNZ eE 2ReE 2 nn E 2Efaoeu ActualConceonfSttanrdaradsftntiheoFCnMisx_ oohm EBE BlEE eE||EEze|||BEE EB EB2E8|EBB 8 EEEOEOOEEE LEI EIEI S| EIETE H cepa [ET = |] VEE3. 5]36 3. 35 I | a | 586 56 PLEAgE m mn 556 556 Zz B| z EE m m vs Ese J: or, sre 000515 Pox 7363747 Ton Pair Extraction Worksheet - Sway F i 7x 120 Surogae SH sop _pom | spFpC.WM0S3dpm|| spFoC.MESSp@p| m| appFroCx.MxSSOpdpm|| InDitaiaelasfdor JoatLeves actual /45 ppm| actual ppm| actual ppm| actual ppm| Std.or 1| mB ommtEEm E g edrT ahgj #W 9gps/723] #W 790//; AW Il)fe #W PF)H29 Comments H HT -- --7 % T mnT 7 = 7 EeT 1 E1 S 1 | E H H H--2-- 1 = e T -- 1 7r -- p --e T t 1 -- 2 1 -- Hi wr 1 [p Pem a dall m guiLeghr lalunefospesFm ermr oAre. --N--Z]--] 1-- t t 1 e 1 p r| Et e t= oetf r SS SS SS --| Ftr111 |e t Ee lt Ta | lillie, saidiitiiss wem=los7 oraZl | q ite Ve Rae Jp) _J/a/9]] ome [Poems nLor GoM vee 70wT Agi. sadoppo | ] [imeTal oro Neco TMNICOead7702-25 | [PotonNisoges Evapomtorio divoessEvagoraar------ Temennm Jvbp 1 | e scEo o wa see oa Con.Choc ed, hmemaias or sd curve-- . =. | FMSi/Mn SDs / /i_CbonDt.Chmecskse:Sspisk0etdm S/# i_luMLeorfoa e3Impip~wsmtdn:p2e90v)-7i~]--_)--_fo--r a_fin_al_ con_ce_nt_ra_tio_ofn_S/ , . 000516 to 71033AB| ermrtrd |r [0 iAEor epE"e,nS, wEBmIR me TcEErEuEarRptao nRi1nmnyo ms2 | rm ERemmsimtmars EI TSonoidsn ] J y R aBr |ETwe TElw ELhe TELSE loa aol [e2s] 8mTlH.T & ] 03B m m00 lm E mako |E0B E 300 E s0|0B0B| osE E w] s e00 00B R E1e0 w wooier 1 5E00 lmsx 5|0B0 |SB00) BEE S00 S00 ooo 0167 g gpp E?T en 1 A I I 599 Ed 9 9 I9 59 5 29 5 29 59 E=l lE z E |zR |2E |2]|3|S tes 1 ows 1 1s=erseTeE , g2ag pv = ip ma e | a |m: | n || 000517 | POAAPROS, FFHSMSI3MEI Sample Weight Volumes Cw TELLS repute 2/17/39 MsSeactmmhpoldeMRaevtiseiA:own:2w(3A)L1700 1 110 pm Study Number: 5TOX [20 `FENlqouaoitpStmaeevntebN0nusdomPbo7aeg8rke::sosFe borearleaF r lo los grnl[aak2[|o0l/e6s7 || | arog]loser1y2.0 |0dbl| e lowers [2e a[ole| | 1nd 146loner [| 1 a Toe|x [als | | ] er | Ee Touma|3.7 |oaee | Tpozasc [2k |Onz | | | ] pares Toda 2)[one| - I rer owas |21 | 6rze | ] `SummaryofMethod: . 1 Exton] Teaplae i ReviewDue ensprts Weigh Vala Stet 000518 Pugetol-- `Sample Weights/ Volumes sd x 2/18/77 Sa ATL gE Study Naber: 70X=/20 etMilli=-& Qldrr FT (Ease1G) PNeNarer Topnoemrs L[A10I [ TOapr|.| Jromeriamnn = ] . ur ail roma 0005. 19 `Weight VolumeSheetxls Pagelof -- Sample Weights Volumes = 15 ri epo: 2 ny , pms p/h) Vinmeimensioe!Yor. 0 TargetAsalptes: Lipa To1-120 FNeostasvbaootdoPaAkgedL: pus hel Go | wiley| mind Ddimrad dsp [22Loder | Gel LoL eTe s|or lee | ed leizaa) |36 |Oder |] oe lomo{2%|Oder |] Db. f12Eo 3 2 = 3 DN0] CIE Due Em 55 e lise . usr e or Dio. 1/2 F 1 neegy ess etm logoxezrd 1|4274[|oodses | | [| (yrs127| Gabe | | los 1327 odes lowpss|2/ |Ogee || | lavaifar oie logdzs 52|oes | | lasrg [27 ont | lnoP7 |23 | gic || Voerzee [#4 |odo logssz [40 |adhe 1 | | iFtg pypaz aa Long| | Jemma . [= | Exrc1Tieompno | Reem 000520 Form Appts `Weight VolumeSheets Pagetof `Sample Weights/ Volumes prep Duta 2/18/79 Anairi:pan TAA i `SampleMarte: Aof rLow a0t.o TargetAnalyte): = Te | Tz To -- (asya Study Number: T 0-/x 20 Eqelpmis open TNaaio Savei sta:i2d 1 4gy, Q O1 ster [me der | okay 127 Loder + Vota =e lm [1g Tors | Mpa ible = V/ogsewees|TcOsTT|oodukeye1 | basis [ae|ode | 1| | J2e4r0e[4 lolli fl TT -- 1 fr t meem er eep r -- r r T -- ] r reer r 1 f----r -- 1 ] 5 -- F 1 r 1 r 1 q f r r-- e r ey ee 1 `Semmaryof Method: . |Not+esF:ossil pondsmriston From bench dep chile wei.gh 1 | Em xecsTem mpus 000521 PomAperettyous___-------------- Weigh Vola hss Patel : 0% apn | SOUP 020199: FACT Equipment Log 99014 PAGE ___ QuaIt,t#6r41o4E | DATE;223/99 ANALYSTt:b STUDYNUMBER{Tox-120 MATRIX:RatLiver DESCRIPTION:LiverSamples. 1 FACTMethod: FACT-M:40 Injection volume:1QuL, Cycletime: 13.5min. Electrode:ZSpray ] MobllePhase: (AROmMNHACHICO? (B)MeQH . TNA-orsmirdmmber (4) 9801214 GINAZE 1 Prepared (Qtcly): (AI2UUS0beS 2mde Expires: wee ewe 1 Storeatroomtemp? [ or N omer | Gua chm Yo | Putoumbera____ Lotmmberma | . Analyticalcolumn: Keystone Betasi CC ] Sizei22100-mm TypeCl8 Spheresize:Sum. . ] Partnumber; 105-7012 Lotmumber:PAC0Y Serial umber 108811060 % Analyticalparameters: 1 Dryinggas(Un):300 ESnebuglasi(UzAi)1n5 g Shgaes(aUt0h ] LCFlowrate;300ul/min, Backpress2u0rbear: ~ "HPLCsolventgradient:Long 2 Do me | 28% 0 suo mo 1 1 a 90ms s 40 e 0 | : | ! 000522 i i eee eredeee etre ere | suntag Hetnos Hathod: Reger comsmosses 2A 3foe sage 1 | eetarea: Tue Feb 23 15159:26 1995 030] L_o 2 || REESenn i' m:s RR TE | somez (mse) sor mak | EGxoceonpretarcrteorry 3s o.00ea2.99 | DRSeFosueLreicnvesatBlioocnk TTeemmp. 00B.520 21%0 sy LHTuaonRREeensseoozlleuuyttiioonn ZWLoeinntsiEpn6ietregry Ramp set mak f1r0i.t0 . 2050%'s iso 1 sressusen : Analyser vacuum Gos cel | i1 aan 7.80-6 a | ws Cofar1tlRRieesssiooollnuuttiioonn Zon Eneray MifeonleSttapier ser mak F11a55.000 2% FO on 650 000523 | eM et rn Saatn Soup paoitt | Ee Uae. bello) VERE pojmmE Ed J EEE 1( paE d E J oo | | 000524 - astm Samio Un ron Scompaa occCuNnsSsineicrssmossosazsmsn. YA 02/23 } atime U1D1 ofmmmemen Fla dM oennaOenn LcNomEns WoFie Wath Both ETTOoUanS rEngos91 monfaomuontE UE REL Sh THT) 111R00 dhMaaaavese Ch Cond Ger 3]N{{E mmmmm ameemeasse mcbmoommmmmmmmmeee1 rsmmeEoesmnnhiiRslS IMEUEEELERIEIREEEELD0i18b0 m IE EE 0 tMtSweeaa da | iBiomaeieesen ifl on imm pmmEmenem mmmmomnirmaiEya eNSE oo O0RJE OGEGEA EREbEEER E101R100 sEAbnEe |BBBTooaomommmemieese 2 oe mmiocmoopmmomopoaaomwgrasmoseemoEssnnR, ots: IEIIJEEEEEEEEREEEEE EE GRY R11b00n 0 AmMAwaaeeee ER fae | BB33Booaomonmemeomsesl moMmmiapmtOasboiouUgtnmeSeeirammaEslnnm 3 me Tey MEROREUEEEREbEEZEL:E E 8 lBa80 s MAMbaeee IE he 1 6 P3Bomceommmenmneehes 2 oe oMmma OoomSmmEnGSoho oeoulse TeTalEaal maoIToEE, MPIWMEEEEOLERLbEEEEE ES 5E DR bb1b WERE RE 0 AarfAwaeeeee @ : . | 3f 8o mmmmemeeestl momnoomenmontaooouo nrnearrgsannn BEminEmieEn TMEMoEERxLLEF ioEEmDEE8E%80nY awSamaweee BEER Ran f4i@o0 i m0oomm22a3oem9mm90mnme50 TOTcooxNon1RS2ma0,DGpABOoLoO2lT2n2r9I-re2a 5v0gEpap0rRn-CC42, cml inno EEA TIJTIIOOoXNKEIUmZEERCEEmlmEoEnZwZg283Y 3a S5 1b b01100 EEE EB aAammcbaaeeee Awe | #@ifGsmmmemmmssess mmlVoOonSmanStDooemmmaayrroaaan, BEEmEmmeEels WTRETOuEENExERRhmEEEgEL8 LEEE 13b8BoMRiaameeee metai sam 8888 # Gmmmgnhmeonealle men mRene rey s MiDOomSmpSdoYo wy urmeean 1 ITmRKOUeEEERHEmmZgeSLB8 5E1Xo311B&m afh0taese UE DZ Same y EERERREES EER RA | 000525  Seansemeun 7 rat | sS amples cuwS assuvoneacr.1pROSanpoBCEzIBRGSPL wo nfas/s [ 8EfoFEcilio meNmanmme Fima Lmla e Tnenixt ommoaIn, T MMBmBSFiiEEElerEDLIbnESlEeaT t]EgBLEEott olT umRRBBe iAEESamRm.pSeleT) ConcA ConcB ConcC EE E 8R R ocCe mmmeo b m molmeo at ndod R ioa e e ina, BmEBNEkELEmEEmF REgF 8BRfEpRBBY Y la. g1 bB7BSoEmo Ezenmecm inimobhnmec esuswiri enaiess, omnn Foi malrasemmen RMEmBEEEEEDELESEZEEEdEB BBBRAAASReN.E mizing Ri E5BeoEem se oemoamnesn mEIiEazSisEnegEARRaim | 8f{fE0 oo0ooo22mn3m9me9es0e99 on TnnmmEoxmomm1m20mmm,eReBeeeLm0sm2sn2a2iem9-anRnnmBLiviiieeraBiaelsks-mhs12, mmm TBE imOXi1Ei2CtSlEsoosngg2ls68818 iE a 2 S1BEBL0 AEonaoSalyEmte BER ooomme m mmem emam niy S ECSS 8RBRHE ] 89 022399108 Tox 120, RBL02229-1000ppb2-722,% TOX12C long2 77 10 Standard | 000526 |= Em 1g: 2. = | Smee we 1. Sosniitt tic fiche | | EEEsmeEE 1 1 ] i | | : | I i } Co . . 000527 le | = mem | mee me | &- = Too... 1 Bie | EEE HEE J 1: Cs: I | | . | Sp_ca00s ue orleslts .. i 000528 | a me iE T=. | 1 1 : | : | | : : . ` } 000529 le De mm | EE. EE J 12 1 Ere | msm OE 1 HEE EE } J o 1 ] . | : | | -- mloshs Ce : ) ! ; . } 000530 | mae FLY | 8 wn 1z | BE im | ] ] Co J. : | | . | | : 2. . Co 000531 ' | FACT: DATA REVIEW SUMMARY FORM Do | fas [a9 mes ) mt: Zies | FACT Study Number 70% _/0 ceptable LinearRange:52 = 750pots Matix | imepoios ] Dilutions? Lar Lee ILOQforthisdataset: _62_go5 [CRees-:cvapflogrudssifteeendt range Dilubivne needed Gor 3gJ 2 QuiallonTy3 Fol: Pros bes: 727275 A 1 ccepableLiearRang 5=500gab coeptable Linear Range: 52 =5400 r OQfur tisdstaset: _5_ 106 |LOQfortisdataset: __S2gods CCC's! i me Re0-0o'vasl;uatipdfroersdifferent range? angle FL noodse 120 Elbeuel --_-- nly 2 Pr nalts 6: = | etabl Liner oo spo ph " S7ee ogspevms Pe Brame podem | L0CQC'fosr"thpisrdiotsasret:Gue2ss5 pod OQforthisdataset: |- ReE exaltea d fo a difen rent rengse ? r [Re-efvoardilffuereanttraengde? --_- 3: Pod 7: i ceptableLinearRange: / =5002b coeptabe LinearRange: | [Remsesne so 5 L.0Qfor thisdatast: | for different range? Re-cvaluated fordifferentrange? | Dk Rend Be 17S and dibabons 1:5 Gip2, 1262 Rr M53. ue | auf | 000532 i EEBEDEEECONT i rinses en 33 33003009 |POa E E Bdeman, jh BSA 1 EE Elam MASTCOPY AVAILABLE BEEg ~~ve HBWW GE mEE == FER 8 EI | gHaEs BSmEEriaeepn, E=w EDT Te he me: Heredala: = 1 BUDA EEE I HLRisen, 1mm ENE mmm Fe EE 3 5 anne REE RES i =e we 1 Tm HomnoBaEnLLE= pmo Ha ME OR ames dels ae Homo Hews em EB ip oan = ihn ceEaEdE 0 1 jg EERE BE LE HALE BELLE OE ELE Car , fh BERT Ew Gan mBE a a som SHEER fed mE ee a WoBnE = LE Banna heBEE fy ee 2 in i a se ans iadsd ined ym 330 000533 . TF-- EE IEEEE .. = BESTCOPYAVAILABLE mr mre --1-- 8 ERR TBroee maces wm rss Cone. NourYisss i EEEaama 0 BEE Shi 4 Reis 1 pPaEmE D SEER ET S. iE Siemam nme EEEESAm [BR vee Pomme mE HRS VE i 3 anne BER eS min | EEE RERERSRL. iE SREERE 2 Fo G ma Br HeER . 2 wr aoss Fd en tnfa Em eee eam on mm am ED es meer (ed BELL a : jE Eftwmaan 22 a 1 E SEHEEEE EEE WREEmRaE EiAmE 0 iE Emma0 E2B u3 ELSaWe aer.sow BR LH wala | SBEEEE pEaEseamsmosEs Bf=p om OB ELE Bis EE EEL EER EE im O# HAE !, se sr st it 000534 --r-- em-- m-- u EE SEREIEIIIT mammamm or a | iE EESERRE Ign mmm fphmm mERHTEEERRIESE.., = BESTCOPY AVAILABLE _ Ti WEE [EE BER A BRE 8 HEE E2R nm ome wm FEE ENE aan pam SEEMER | fi sae. BEE Bus mE 1 BEE BREE 1 BEiEEEE ESEWmRamemalan:t 8 Ww Bu 3 EE fm LE BELLE leba wow om(oa 5 BR Lam m8. i EfBaHELLEwWe oWEmoREe E:Ef | iE Eaten I gas Bigs BE EERE | to 0301911 nmin mdpeiREedByman 333130 BE EEE gE mE mE BARE om ER AR 000535 EE ET Lo Ein. SEEENETIN BESTCOPY AVAILABLE A mmm To em time EEE ie oimE EEEEEEEE I oSgaim SEnEEEmEERERALRU BEEE afimm 8opBReAnS E=ER EmER.IEHO BERRGEE HEE EERE Er pEEEEEEL. EF | BE BEE Sim man ERIE... 3 EE i | iEa i ERmtARmiL.. dhmm SEE 2go EY fans Zmsumum Be ded eee seen] ol . [ mem wns we H Hp HOHEi EER LEE\ue ey' WoEm f Ha TESS Bim mado 1 ifaam ESEaEmEaEnEtE. 1 GEE EERE | EE Eumhmas, 5B dod s Ex woommEE EBuELLEEaBsEE Ge (ha 2 i HEE OZ i= sR, i HELE DOERR Edemaesn, SE |oioHE EREREGR GEE BE EEE EE Zim gana Em OBE HRMS SE |1 J ----2 000536 SET I ee fads Ep-- Ee_me mmem ---- | mwEss0 BOTT TTT Hemmer nun ERIUN E mn ame dE HE ER OW io ESSERE 1 Em EERIE am Fo meow an mea sw Joma Immo mG VE Amie eed wn mH 2 Gomme mEE aS EN = ed mn Ee 2 Entered SE Elta Ba wr B OEEEs pa EiTamsaas HEI fa EE 2mm | ihe Eimmmamm00 iE Ei wesmneon IEE pad Edman, EBEEEHERS | BER EEEEL J ed 8a [ET I I Er he Er seca 30 3 22 #2 BR EE ALE 22 wm BERLE EE cm [== gh Dal gnaE HERE E mBHIE 000537 EE ] i, EEE------ (E{EEEEvEEesiEEEalRiaiIsSmeoE tmu emResaR avma. B= BveEE macms 0oma ivH ooEw BArBoems ECSooImpeUe.\GDSowwwEEFsises EE BEE HERE j{iEmE BBEoEmR EESSinuEaEEEmdRREEEeSmLaiUmR BiEm2 BmE; EE H HEEREEiE 2 vm oma us | EEE SEE | fEaEmE EEEERERHEa.e.. a B= we H3OHH mHuE EaEs | HjpEEBmEEnR SEEWhE Rs miREmEm . E2 E5mBR La1BioBOBE EBEREEEEERR wo EEE | pBEEaEEmE BBEERdR EER SE. BBE EL. H BOHBBBIEEER PEE Simoars um EpEaRmE B EE mE mZ a. 2% Fa= WB BEE oe BmOm B m BE LGsE | SEER Bub oaa an | EEEEE BE REA E 2 WB EEE [23 eB E EEr RE . | iGEEE HEiHdEaRaEaUsR E5B W WOBE BBRREA 1 dBF idEoaE EEnbR S SEEERSRRSEEe EME uBmb Ea .dER.a . SEE BEL | Gaim SREREAR | BE EE E Emmamim HEE Eiheen | 7 ome od SBEEEED BEEE EEmEaRn RE |BBp EaEmE B BBEE R E EE E EE R E | Ei Bom= amaBm OBsEHeBEEaRRRaHEEwE mom am ZR LE BERNE Em BRL. wom ESE HERE i LEB SEuE a we =s om B EOS B IFHEE EHBEEE OBEBEERE OBR EER Ea= 000538 | EEE RR ess | |C[oCroremlpaotiuomndconefafmiec:ieEntG: rS= 0.999604, 2 = 0.999208 Calibration curve: 28.4213 * x + 269.890 | mn Cia cui,Weighing: Nol,Avsaus: None | ax 1 o 1 1 } ] | . | reer 1 1 . ] . I | . | | 00 2000 4000 600.0 | ct im me 0 | os f , 000 pr 00UEED Vo EEE 1 (Compoun2d ame: FFAS - Correlation coefficient: r = 0.998267, 2 = 0.996537 [Calibration curve: 21.3424 * x + 163.104 | [Responseope:`External StdA, rea - N ) arve type:Linear,Origin:`Exclude,Weigh Nultl,iAxn istgran:s: None. 1 2.154- yo . ] 1To] ] . | . | ny o t ] . . oo ] . | . . | | : | 00 2000 4000 6000 8000 T0000 | mem----r 000540 E | gm ETE 1 oormeploauinodn3coneaffmiec:iePntO:ArA= 0.998245, 12 = 0.996493 " Calibrationcurve: 335408 *x+ 3.1571 ]|B ks `Weighting: Null, Axis trans: None: 387: a ] : 1 1 : | | fl | |e 1 } 1 1 . | . |1 | | 00 2000 [------------ " 2 4000 6000 8000 Toho 000541 ] re 0= 1 [Compound 4 name: M513 - Correlation coefficient: r= 0.995618, 2 =0.991256 | [RCealsipbornastieotnycpuer:vEex:t0e.r6n9a8l7S8t1d,*Axre+a31.5781 _ ] . Curve type: Linear, Origin:Exclude, Weighting: Null, Axistrans: None ] . 11 | J|| | ] : - 2. i . 1 | - * | x, Fk | JE 00 2000 400.0 . . 6000 800s0ooo T0308" E | fort | 1 ompound 5name:M613 Correlation coefficient: r = 0.997791, 12 = 0.995587 (Calibration curve: 2.28142 * x + 29.8900 | urve montyepe: LineEar, eOrigitn:eEnxtclsu,de, WeigWehitghitningg:: Null, Axi-- s trans: None 2.683- 11 .- 1 i : || : |r J l ] . |. . | . Z . ns - | x | 00 2000 4000 600.0 800.0 Toda ms sin tre 000543 | me EERE SE I Ee Rens I | Remora ots Response ype:Extra Su Aes [ee 3 Ce 1 1 ] : | 1 1 1 . mee x: i J. : . 3 . | :| 00 500 100.0 1500 2000 25C0o0nc. to 31311 tad 1 estas ym 388 000544 1 Ve lm nm Stuy oan palaala |] EE. EB | me m= 1&5: = Too. | messmo oR | EE IE 00 1o i ] . | : | | . } ) ) J 000545 ' - Of | QuSaOtUtProI0T2,0#169491:45FACT EquipmeLnotg 99014 PAGE | 1 DATE:2224159 . | ANALYST:drb * STUDYNUMBER(Tox:120 MATRIX:RDaEtLSivCerRIPTION:_LiverSamples, ] `FACTMethod: EACEMA40, . Injection volume: 1uL, Cycletime:13.5 in, Electrode:ZSpray ] Mobile hase: _AROUMNRACHICO2 | BIMQH 3 TNA-orsnddmobe(A)980204 GINAZK 1 Prepared (Gately): | (N2ILU9hl 2obl 1 Expires: wae. @sm Storeatroomtemp? [ or N Other: IJ | Partnumber; Lot number; . 1 Analyticalcolumn: Keystone Betasil | Sze25100mm TyperCl8 Sphewsizmfum so 1 Partnumber: 105-7012 Lot number:PEC09 = Sera umberlOBSUIOD 1 Analyticalparameters: Drgays (Uin):n300g ESTnebugals(zUhi)1n5g Shgaes(aUB)tQ-h ] LCFlow rate;300unin, "Backpressure:120bar : | pon I" HPLCsolventgradient:Long2 no deo | 28%. s00 0 200 _ | ono so ais se | | ). 000546 . ; - | runing Method Report Methods CE\MASSLTIE\PACT+1. PRO\ACQUDB\FYOS | erinteas Wed Fab 24 15:22:59 1999 2.0] | =E 7 RE E ERRMR R RET oa a S| Page 1 Ct 1 |1 SE a |i us somcz (285) | cottons s2e0 m2a.9x ExCotnrea, ctor 5F -- 1 SDReFosusrLicevenasBtiloonc:k TTeemmpp.. BF0.Io2 as 1. seessuzes : nas Anayser Vacuum 1.204 Ges ce11 5.203 | STCOPY AVAILABLE B uJs -- To4n'ReEsnoelrugtyion prZieottnyiEpnieiregry Ramp 1sor0 max 240',s : 0EEs0oE) - usa Coo1rtlRRieezssiooollnuuttiioonn ZfTeoonnns'EEsnneerrggyy Ram Zietnsip5ier set mam $ i1s5.00a $ 2o%a a o so a 000547 : etaets nd ran 34 33023138 1999. x | mmr is Rt JEELETE | BE ee PoE VER RE. [mE po - 000545 . EL | Maamsosinynx-SacmspsleiLnisatcencr nosmpuosezzenss. No nt Printoc:WedFeb 24 16:25:30 1909. o &) M99 | FlloNamo Fil Text WSFlle inet] Bott lume SampleT, ConcA ConcB ConcC 213 0GOeg2aa2ii4cg0eo00n00t1ss MMTeeoOOxH1H2BB0llAaannBkk LO22ZB0IH,22202 TTToOOxXXiIIzZZcC lnlaonnzgg2z 8911 111000 AAAnnnaaiatle 1 74S8 000C222o222a444u300g990u00000000450rTTTTooooxxxx 111122220000,,,RARABBBLLLB0OO222aL2ZzZ20S9O2S-18o0R02pp0Epo0Lbt12-I,1,e2,r2Z22B222cS0001290, TTTOOOXXXIII2ZZCCC TOXIC lllaoonnngg222 long2 324 111000 10 ASSStaanannanddbdaaaerrrddd . 1%90 G00e22222i44s09h69o00001n00TToTooxx 111222000,.,AFABBBLLLOOO222222z72s88S12oS0pOdpoopbpo-b-id1,,,22222222210! TTTOOOXXXIIIZ2ZCCC oolonnn22g 78 11 Ge200011 Tox 120, ABLO222S sC0ppo-1, 272 TOXIZC long2 111000 SSSttaaannndddaaarrndd 10 Standard 9 111324 CGGaa2as4siGss0oa0id1si.4s TTMooetsOi1Hs2n0BAaArBBkLLOOzZ2ZISI1S070S0OpP,P222O2, TTTOOOXXNIIIZZZCC llnaannzggzz 118102 18 Coassois Tox1200NO. 145F-04,22280 * TOXIZC lanz 12 111000 SSAtniaanndddiaasrrdd 10 Anaee 1 111578 0aC2oi2as4is9g9a00ni1ie7sTTTooocxx1I122200000DNNNOGO..11M44MTsGFFF--OGaKer.25222022880090 19 GaigaoioTox 10DNO. liOFok.2228e TTTOOOXXXIiIZzZCtC klloannngggzz2 111345 TOXIZC langz 16 111000 AAAnnnaialtdeeo 10 Anaifo 22510) 33 GGGaoaariiicscaaaoasztseTMToeoxoc1I2Z0S,DaAOnBNkLOO.Z21ZS0O2F5OGpAP2B-zO2O0MY,1 TTTOOOXXINIZZECC CapicanssTox 120DNO.1SIFG4.2z20 - TOXIC lolenonggzzz kngz 118782 13 111000 QAAnCmabee 10 Anaite i 33E 5% GCooppE iisoaaoosstsToTt oxxIi2Z0oDDNNe OO..IISScFFQ04e 4..z2zzoaR0d 37 Coaisacar- Tox 120,ABLbZzS2500-0012, T3 TOOXXIIZCC llnnggzz TOXIZK lng2 22E10E 23 1100 AAnnabae 10 OC | 2350 30 GG0ap2oi2is4sa00c90s00s83 MTTeooOxcH1i2B02aDn0NkOD.N1O57.F-1GS4,Sz 2E22G0e a9 TTOOXNIEZ TOXIC olnzgz long2 2862 25 RN Pichon) Tou isosDarNa pom.a0 TOXIC kngz 27 1100 AAnnaadse 1100 AAnnaaibieo Tou 1200No. Isor.0a.p00 TOXIC longz 28 10 Anat . . 333354 35 iCCoocaaaiugdoaoso0e0ss4TMoouor12B0,iAnBkLOZZZO250pp.COIS, Coouaaas TorT20DNO. i6IFGS2208 TTTOOOXXXIIIZZZCE llboonnngggzz 283030 111000 QAACnnaaes 2 333570 CGGospoiiisecaaaoocssosss'TTTootoxx1Ii2Z002DD0NNDOD..NiAOeoF.r-I0SsE.22222Fz02Ga90S000 30 GooseaossTot I120DNO. less,2z0k0 TTTOOOXXXIIICZZ bkknnngggzzz 33310 TOXIZC lngz 34 111000 AAAnnnabeae 10 Anal | 24G003 GGGoaoasouiieeaoao0ouis1zo EEE TTNooeuro1122B00,iDAnNBkOL.OZ16Z9Z7O.285,02p2p0C0O0M,- TTTOOOXXXIIIZZZCC lllooonnngggzaz Rh eran roux mm x393530 111000. OAAnCnaabso x Awe 44155. 47 iCGhadobuioassaiooitsss TTTooloxiu12Zi00D2DNN0OG.,DN10OO9FF..0GlSS,5e22ee22a0rv00se80| Oainiodr Toxlao RELoossecsopbCO1S, TTTOOOXKIIIZZK TOKIZC kklnnzggz2 ong2 324890 41 111000 AAAmnmaadeto 10 GC : 4888 GGDsiii9csi8ao0os4ss8sTMToeorOcHIiBZsoa0DDnNNkGO..I11TdIrEaGsSgZEzaanRe9 3) Gasiouos! Toc IZ0DNO.I7drsszand TTTOOKOXIIZICC olloonnngggzz 44823 TOI lngz 44 111000 AAAnnsaaes 10 Ams 33425 5 GGGooossoideosaaamcoossssssTTooToxxx 1I122Z000,DDRNNBOOL.O.ZIITZT7ZSF0r--0a50s02gp2pz-0a0n00e01S, Ozaigenss Meo Sark TTTOOOXXXIIIZCCC TOXIZC klloonnngggzzz longs 444857 94 111000 AAQmOmiee 10 Anat |B55 CCBoibiEiscaaEcceysTToTotorIh1Sm0:Di0NDwON.vlOae.0rIF.FcQBe0z2v2zm2zme99 | 5 CibicaossTox IZ0DNG.1eIF.0822299 TTTOOoXXIIuCC lllomngngza 4S&9 0101100 dAAanmeee TOXIC lngz 51 10 Ame 000549 i Sass sampio it ] sS umpiousovuT ssunoneaor1prossnpeomcizisast: 0 rt MIG | 08 Plotane FisTon cmEeangmse TTfoneoonmo.meacron, MSFle ist Both TMDOEEULEbEzSE82 me Sample B1N0 EEAu,e Conc CaneB Cone 888 dommiimieeeas mos MmpmTeaooiiomoSmoeokrgrioeeeeaecios,narnm T1IE0UE0EE%SDDEE2Z 10H BS RHE RiIB fbB Elf mAeas hAeW 88B gwSGoe5mmy8i nocmaisn aIMlmoOgnonHcocmSroeEcmazKaeen, toleBG, EDIDIOMRELEE S0SSSD8EE8B 88 bBBI1BB EXMMeaa,ress Tons a 2 a 3T 773 Smmcid eimnemss rM TTfoommmmileeorS aresulsehoosms TITOOOEEEE Tous BmmB2SwResB88 18101i88o MMMd,aaavmeee Bom ||B8880 (olm022eo49t9es080 TMmaoOxomM1n2Ss0i,rRemmBL0eem2o22m9o-RnnBaLnievmearseBIikc-ns1ed,2, TOUR TOIIOXN1EE2KC BG lB0EonS8gS2 R6888 ib 110. Mars ASSnahlyhaten If Shan | B88i EmGcaoaEtsoe a clEooommmRmmmmmgeRoGmmmEmaaauneEeerereRirataassoyy OsUINKKErCGC28Ey111 INE 0S 1R1l8b SiSShweamaannn 1 Sian | 89 022499080 Tox 120, RBL02228-1000ppb-22,% TOXIZC long2 77 10 Standard 1 " i: 000550 | FACT: DATA REVIEW SUMMARY FORM - | Date: [Aq . 1 Analyst deb mae Aas `FACT Study Number DY 20 cocptable Linear Range:/20 Jeno Matix Ref lien, [LoQfrtisdmuer foo | meres botoyps Y-6 Re-cvfaortdifufraenttraengde? 00 ] Dilioas? No : et: Pec be: NL 1 Dope isearIhS)ajmogomsh copter henge/ .-- SSO 1 {LO forthisdataset: spb lL.0Q fothisdataset *_ { plo | . [Analyte2: pra "So 1 0Q forthisdataset: Ellman | [Re-evaluatdfor differentrange? ) 3 Tupi ica PAE I=250p ] lLoQ fctis etnset._ S50 | [Re-cvaluated fordifferent range? No lyts 6: VAN 3 lLOQorthisdataset -- Ire cvatustod fordiffrentrange? oT copeRs [LOQfor thisdataset: --FRo-evaluated fopdiffereat | ! 000551 ' | oo BESTCOPY AVAILABLE =i [J p------ Of | S mmL B meEeEnR lol | iE EE on Be - = ei SHE Edman EH HE opm rman edd | HEHER=E 5 BG | mm meee Ura - | go mmm | im ET CL Eimer, mem mn fg 3 J= HE BE Emam ven BSE Eoggiim om EEaEm 1 EEE EREEiEl I vammBeE EA Eo we n wow of imo A omE iLiRE Ha ime E REE am mal i #1 mE : | moau,ist.oSuerckesnal \ RE SERERIE 2 HE IEEE e wa Ee UHHONEE R PEE RE : woei . | E{SEEEEEHD ESEEEEENRaERLEE.w BBe= ER a HOH HE 1 REEE : q BESie - TEE ER wn BE I see ins Gutiite on $8ond todo 1 hin wom aE000553 | BESTCOPY AVAILABLE . i m --_-- em mm | EE tin, E sE rE -- ma fT O[Hoh | o-- E--EE. EE | GTEE mmm ETe EE Ba EE uR Emmis BdaEreE HER 1 GEE ERSTE ER 1 PEE EEREERER.. BL ji Ei amaan BR AreaBh. Goda.Thaw Dwr OfBRoam WoLn a1 soasup od . meow woe | EapmdEeRn EEmRoREmESRHREESAERL --. hi EeE I - 1 Bee a end olieli | Hh BERNE SR Hom [rot hak et sll cole, Th lng Co. wa whi cri bce lo samples Ts re vans cucaon renaksess os rain ws eds mobbed specs ad is 0k bo pol, i . ee | sg m mm g | EE pr eS n BEA m T I Org - sor ~ nt rd -- 1 Pan mmm Gmm jE Tain RAmammamml, ER Ba G0 am no sw ou Hane mes Sh f= . Lo . 1 iH EEE mm - amen wm moa maw 9 DEfmEEEssEsEeaaann BEEE | EGEEEE E EER RER ESSy we Lo HERE EE wmv a2 eon m2 2. . mans BR Hen, am Eo ame ae moa maw 0 Rm Ei essen Si wom mER | PEEEEEEnEm EEmEm BBeE pREE Haman Bm BBRiRa OpR iLBeEsE d , Soup 8301391 Quastioat0A3/t03e/3d9 sodpri a s 83/1t 0/30ebyd A 000555 iy gin SERRERCINT | rises edvar 10 Sp102i330m0 ofTol Te EEE Bp me Tm es EE Ean, BE ] jE SREEESLEL gm ROE : jdm EEEERA ER | pHoEmEm EEREEGER ARE 0 oEml oe HEE TEE ER 2} PORE EERE0 BR see | HfmEuHHEma EkEBRe Ea BRSSE IN Es .. E=E a.. sae LE Ermaany ER ne mn mee ; ai, mn rs le }: | EEERESB EEE EE HEHE Sa raamenan, Be Le ames os HOH ERE en sm mn en 000556 fel Quantity Comonsd bumary Meport. od | BETES ET Timed |[ BE E BEER s ne mma INwhol | H (HEEESnE Beamma enm,h GEEEEEEEEIRE BE BoEm,a 0 ROBB Ep 3 LOLEEEERE LEER 3 4 ent } 1 HEE ERE Be Cn hopes ow } | | piHiE EEERSEaan BBeE EER EAREEIR, ES MUWLw wOE pIBeEE LEB DREE 3 3 | iE ESTasa SE mom iBEs 3 : | EEREREERdR | GER ESSmam ER OE EEE 3 EE Wm Biggs 3 : BEE EEE BR gm pri : fabs mummaum Bg WOH ESE % | GEE ERREEEE... 5 ow. HOR HEE 3 | sa EREn ERn E BR EEE Bom i . \ ie os tt 1 i n 1 1 000557 --- | Gm m,amsm gaan pnmee ER DIE ES |. [Compound 1 name: PFOS |" |Correlation coefficient:r = 0.998526, 12 = 0.997055 (Calibration curve: 23.3472 * x + 297.446 | |[CRuersvpeotnyspee:tyLpien:eaErx,teOrrniaglinS:tEdx,cAlruedea, Weighting: Null, Axis trans: None 1 2.95 es * | i | Resi J . . - ' : a | 00 2000 400.0 600.0 | sn tit 800.0 Gono 1000.0 000558 sm mm PSir.ee Sr ETIr [(CCaoolmmiebplraoattuiinoodnnc2cuonroafvfm:cee6:n.tP7:3F0rH7=S50*.x9+8816513.77",287= 0.978184 || {[GRuensvpeotnyspee:tyLpien:eaErx,tOemragl:StEdx,cAlruedae, Weighting: Nul, Axis trans: None as 1 ' x -- ' x x | . | | Respon: - | 1 : 1 . x x . . / . : ER | 3 cone | 00 2000 400 500.0 8000 10000 | tt 3 2 000559  wR - | mime. EETERETT | Fara SdAros ) 1 i [Compound 3 name:POAA orrelationcoefficient: r= 905784,12 = 0.991546 [Curve type: Linear, Origin: Exclude, Weighting:Null, Axis trans: None 2.9 | ] Lo . 1 1 } Co | : . . - -. oo * ; } ) | Respon: 1 . J - . : ] . . ~ ] : } Lf | | | ts soho abo oho soho 10600 ore , tp 108: Guamtaned on 83/00/38 and prised oa SACI By 3 A 000560 i o mie ti en - | sSiom.m, e HETEe RNE e [Compound 4 name: M513 ] orrelation coefficient: r = 0.996106, M2 = 0.892227 (Calibrationcurve: 0.577960 * x + 20.1878 | ee ong Exe, `Weighting: Null, Ads trans: None 1 ] 1' 1 1 | . || Respon 4 | : - nt % % </ 4 3. 1 : | : | | | 00 2000 4000 6000 | rn cme 03/019 setae om 30180 8 } Co 800.0 - 10000 Sore 000561 I rr 1 eSoEs, S SREREEDER | [r(CCoaerlriebnlraatttiioonnsccuoerfvfei:ci1e.nt8:89r8=40*.9x9+672384.,42502= 0.083479 | [GReispotnyspeo:tyCpen:eEax,teirnial:SiEd,xcAlruedea, Weighting: Nut, Axi tans: Noro ]1 Co a 2 1 PB 1 | | . | Rospo ya ) 1 1 : ] Lo ct I . | i | oo 2000 400.0 `600.0 800.0 en i - --- " } ` 10600 C: one . 000562 SEY mE EI TE TRE [Compound 6 name: IS [Response Factor: 1.40007 - |Response type: External Std, Area. : : [Curve type: RF ! 847- | 1 co C | C [ : i 1 | ) | respon rants : A net x & . * * x x ] :. , . | . | i 0) 1000 2000 3000 4000 c: one ae tn Dk tn 1 SD 0005s ce dibs | EEE. a 1 =m wm 1= . | EE po B= | me ow 31 == oC Soup 020181 UC 03/er/s3 or NE : } oo aCo | | 000564 : | EEE... Eg -- l= om FE | fmm w | 1 TT | . | } | Ny ) . . 000565 . | EEE. EE I= ] | Bp. | eam 7 == ] I: | ] I | o ~ : 000566 | ESE... BS 1= = ! mo me ow I. | Po | : | | | | | 000567 o eines uedar 0913:23,01 1999 | ERE. EE 1 ze me 20199 LAC 03(08/94 : o 1 ee 12 EhemnaEL, ue l mw pm 1 : I 1 1 | : . 000568 . | EEE. EE = 1 | Bre | ER ie | me pm 1 TE NE ]. || | Co . " Co 000569 ' | Jeu MADELINE 041098: FACT Equipment Log 98053 PAGE ] DATE, 030189 ' ANALYST:tb : } | SFTAUCDTMYeNbUbModBiE_R TOX 120 _-- EEE MATRIX:ratliver DESCRIPTION:liverextr. dilutions . Injection volume,10ul, Cycletime: 16min. Electrode:Z-Spray 1 Sores? [rN Obes 1 Mobile Phase: (A)4.0mM NH4CH3CO2 (B) MeOH. 3 TNors-tadrA d um- ber (A) 9901-19 @)INADYU ExPpriorepsu:d (aay) N[iZe19mee | ()2F0108559db 1 `Guard column: None : Partoumber za Lot number; - . 1 Size:2 x 100mm Type: 18 `Spheresize: Sum_ * Part pumber:___105-701-2 Lot number: p8f13 `Serial number 118739n 1 mere ) | i Analytical parameters: . | Drgyas(iUben).3g00 ESTnchulizi(nUghg)a1s5 Shegaas(tLkh) A LCFlow ate: 00unin Back esse 120bar ] T1i-m0e0(0min.) %wnB_ : |: | 2) 85 9 Q31s0 2 10 1s 10 que wo . : . ] 000570 . 1 | noninvases nepore o3el [ad Page 1 Mato: CMSSNOARNTS PROVACQUDB\PFOS | pesasea Mon Max 01 17:17:40 1999 |= | scooupmtcraiary(`as)e oSarterToancstor Saorneni'solonck TTeempm. s2e0e0 m3.a0k0 B0.2u0s 1Z3o0 1253 ] Pressures Rebk | Analyser Vacuus Gas cont Gens 5.33 | | 1 |I iT15moReaEsnotelruedtyioRnasp LWeintsip6Lies s2er max 13550%7 . 800s Ms2 1EialRRteeisstogelinuutciioonn Son Energy TbWoinetipaismer Fes? Set Rbk 1305.020 2 $eso na 000571 | Emme, OI | ET rman | hin ERAS | 1 ane wee eas " " 000572 . ---- 1| mS `SampleList:C:MASSLYNX\rats PRO\SampleDEB\030188.SPL. 2) rr [11 i| 11 Frohne ogvpemn FlaTen vdeermoe H oi gmmoeomeesnL ToTnooummme-- msaetms-- wiE)Ci.-- m,Dm, 5i ggSmuuuomeeom ITT Teoeiammmmmuaammsseime ig,yn 1B1BBooBmmooE:nm I mcmmheee usmmmpanmm liagaasm, P 3BBoemoonse E T T Ye imoo e nsieL emm m eerssaammmo aaessn BBgFI ooSeoersms Tmmoommaomnieimemeirmmmcns,, 2n#Boommommomemme Bowie flTT eoemmmpooie leommnrrzi eaemameml geesst TubOESIINoYe Lo g223y 8 mpmsooeemewwmes rmTMOoSmEomoRlomomooaoiiagummaneer00 Tempo means | 333 0fo301eo990mm33 mmmeevurelvmmm,, Tox 120DNO. 141F-2/G232/,89 D2 1336 i2 0C Eim30o1m9Fm90es36 Tm rOox e1E20emDSNO.A s 1p4S2Sm sF2/-2,2G/a9392D2,2m 3 44L ocpmooomunnssse mtoMeomoHniEmMmeaSucrmeemomeusmbsua2az2maem,, 1a4fepmsooemdomess fmTTnoimommoomeemmmoasilmieeigvga,vdy , | 8 EomEe m mRa ums mIsiiey 51 52 mex 030199051 030199052 missinv:ay Tox 120, RBL02229-250pp27b2-2/28,9 Tox 120, RBL02229-500pp27b2-2/28,9 | 54 030199054 Tox 120, RBL02229-1000pp2/b2-2/29,9 WS ojnm Werle Sota weam woto SeooaEmek. Bee=Sew 2 TTomaameems m==mME:f7 TjaGEmsmR o=Sew=Bw o8p jajTommrh w eeww n0 omNTmkEmt l2 lmwwe 831 ofoToommmm Ss=eEww 222oo TToTooonnmm EeeeSmww a2= jjmm eeew2 TITOXmu12.m0A loBBngM2022O8B Tm "TOX120A ojmm leEeongww2w. 3820 EM ommRes EkGkeeE 383# ufImmiEE EBe F3 Eg 2 Tfumm semo2 os TOX120A TOX120A re long2. long2. 843 44 TOX120A long2 48 Facort sum o rJfwoaamnn S2 E==E=f I:i EgEEa = wo o= A 22g3 aadAaeow 2: a HiiE 5E 02iEAanea,ly 05S EAm2ona,ly 13 %2Adao,a = } =ga oo 0 Stand 0 Stand 0 Stand lomon taediloinnse 03fotf59 rs uc Telsg ". 000573 | FACT: DATA REVIEW SUMMARY FORM - - oo BESTCOPY AVALAME Analyst deb FACT Study Number Tox 20 . | vn | Teer Rudbiapers Sous) i3 ohafy Dilutions? Na psd ] aalyts 1: Pics 1 compas LinearRang: 5--/02ph oqeristinier. Sppb 1 Re-evaluatedfor diffrent range? Mo aed DAA ceeptable Linear Range: / -- /coopb Loqurtisduases _/O pob [Reems smog (Jo lyts's: od onea U0] 20 cope LisorRg | C|, = 0p + OQ tisdunes JOOpry dh [eRo valforudiffarenttrnege? _NJD__ . | nays 2: PeHS | ceptable LinerRange:_/0= J oppo [Lo sor tisdatsear: Logo I hoon i itrnt mgr MO 1 nalyis 3: T malyi6e: _ pabeha |Chonin,S67 coept wilt ecany, 0Qfortisdataset 35S2gob slop e--Y. : [Amalie 7: Ses 1 LOQ forthisdataset, __SO) Ro-cvalustedfordiffrent range? [JD i | 1 | |LOQ forthisdataset: - [Ro-ovfoardilffuresnttraengde? _~___ 000574 ss, uantityCompomnd amaryRepost. || iEEpEEoEpeEmenERs RREe | -- en mma ({(i iEEBEEEEEE EBEElEaEhRResER sTages, 1| GGES83H01EEEo00E08 fEEZ EEox1EEE1E6, ME EESAsLAIEEanME omLRtieliE,IEahSETUN BGIhE EEEREEoEamIe aInNsE 1E PBioEmEO Ea Bi EESRsahm Roee, arn 1 EEE ERE EEE OE ERENT. | LEaEmE E Eda Rms awe my | 3BPSlE0E10E0e eEEcwBRlEakTIeeEas.Sn, BpaEs EEeEeRmIe,EJ , | GpHi EEEE E R EEimEm mImeRm, 1 GgGuoEm EmBEEREaEmEEEeRlSoAEuEl. 1 sinnhoiaEmm EE E EEEER EE RESELE E AS - DoiJsosl4 .[ BB B 2 mnE E o mm LaeoE mm EmEmoDiLmime EEHEoEEEEmen BBRoEaEl Bomly OHHE: oa EEBBtanEEEioa OdOo13Eg0E.EE0Ei0 InieEn omSoonaHnS1h `EaHmS2aEEEiEeEEEme 3 8 2B2 EEEmmr EEEE BSEBroEnrommoeomiWnEmomEoEbRmD mEmSuEEEhRE a BE mom EEE ER oe dE HEE a B BE Edim oomm EaEf AnBBnireoa ETm B0eDzD1 SG5E0EsEE a EBA aiwoam WaEkE EBBoEe .me.iTdEUlE WHEmERD gTMHEEERE mR an Em mBmD FBEIg H HHHB ERE EoOgE mEBSE EOmEoBaOgL8nBm EmEgfEEEkFRR 337 | ici iseod od nn 23 000575 : | S poEuTL peIST ---- ie EVI TEI _-- | Er | IEHiHEEEoEEEE E EE ENnE haE emmeE oeanE sliS,aing, I EE Ea 1 SiHEE 10 030399010 DEiRnSEEERELEUmL Tou120, MaLAZIZN-280ppe-1, 2/22/99 1 EEE EEsmEims EES CES MSIE 1sxoimets Io ae, Beleaan-nime-cci, zm 7 RBiEmEs EmEatswmsaemsss ppHm i: EEREERTsMsiSREE, | PBoEmEeR DEoRsiTm L. = | 1 i BIRSoa5 S ImmEe EEmE SiREEi sEsNdmSmoeIEsne., | LdaEnn mENEES Bom BE e Eme s, am, 1 B1B6 oIiEnoEte ECEE a ER , I Tox120, MaezIIN-S2p/p32d/0,0 7J BpRRoEEmmmEEst EE mEamEm EmmeR md esE mae iu, mas Oo has Joa Im Acme mo BBE= 22E=E ooi pampiuEn 9 ane SE EtEaEmoRm0e E6o8n5e2 mmpien Gms atoe BmBmiiyl. EOfaEEHuER ooOwwY og gdp i oaEp1 Dm B2m03Eu00Eget 23- =r = Ee em ser sraew f== om om E=R pe wn ms msn ow 2 En ESE2ERaRhen oe an nen amr ams mem ow mon ow EmnR LEmommn mmaarm =farn Po w om w h . SBtan2Eds Bo3E.9pGHi6M2 oAwmi EaomoEsm 00 og EBEB==aRdooSsiteiiilE MSaEiIill BggBEaEuEsE 3 32 | as onns desti edSStH e4h I 000576 . } et Rr OTE -- EE REE 03/08f1 TT | | EEE8fmEE%E. ESS FSEEmiE EE aEnE REeELE R r., BB BI2EEB auua " 1 i1IS(10NEEE00Eh EB ER EEouEEp nR EmERp aR E sEasa eE ,En E BHE 552ERE EMEBIaE EwEEw OS4E oOomIm E 33 5 gaum8sE e wou4g IHL A rerme = 1 IiPf SiEaimEnt ToEEn RibebTsee.EmdirSesctI, iaSa/Emea,e , EnFSri own men |EiEE B EEEl EEErmiE E5n . | 2L EI9 saEEvesE TEEou1i202iTeE .1t31,a22EMnMB2 anEB8airEBrs nam ar mow a , JIOa EuRmAmGE. 2BL nan we mms os. |{ IHEEEE i EiLE ws umJs F=an 3oan Im i, Tisza aspect,22m En Mm a wa Su s | BE smmEmswum0 BRO HE BLOBEE REE Ee an man 3 ' I PI I EN BEEE REREEESEEThh 4S 3019S Tex120, WMIAZ2S-RALIvNEALR-L, 3/23/99 d2BBeaZrOs EB ZoaRn Ee .NmEwm 5 EgmE3eR8w a1 ] II330BE00 ESEoRp TeaL Tow 130, MLOREI-See, AEN BSBanEiaElREeILEi6 OOoBBi HBSEEaEEw a3s4 |J 000577 : EE RETNCTE, | iB mo,EpesD meeE men | smomm ---- | wH{5 EEnES m EE ERS E i Re E An YN a,m 1 EiES ER EE EE E 7 GEHB3SuEaEE19nE0EE6nS00 TEEB Eon1EE2E9,EEAAELEAZEERmS-LES okspee-ia, bu2as2hM BE ERl SEEE 7] mI PEmEmR EEBEEREEsmEILinLnse. 1 iI EREEENEE EEEEEAEEEEEBEEEsSEiHmETiR. | BBEEEE BEOiEbai aamn | I fBEaER EBESEEESTmEpSsEOaaSmEAs. | BEER ERE mm mms | EHHEEEEEEL EEB EiIhEE eEansE mGeR gmt Eilean, 1 a m LS SfI HiE ES Ei TS oBEBn EEE120, MM DHMLE GZEIES-ZR ESpEpeL-s d,LS 2/E12S/h90 q ThaEe IS k te,mE sn eEed R 2H, oh po o3]oofft ) Be mE BISER gmBBxE2EE.Bow- mr pam on SE BanEda L0O0SsEE1i3E6 Om3Bi wHBesEEw a4J B=E EEE HES m aHmIi BmaEk 4 mBBrFr .8w"omw 5mi FmnauEsn . 2g=2fo... HBOOBBBE OHEEEERE =2[r- -- wr wm iE2R im an mens BE s [EB =r oTM EiWm ommHiD pmmauEn . SE g i EESBBanX=daEoRopA2 adRaTiiReamE BEoai1Ime SgwwREorREme 3 RROOMMES a iE aEald dmnasx 33 | dito su st st A 5, 000578 : TiRmEeTCLoTI, FL . it ssn Compoun3d1 Talmasifs " iLEa iEm SaBEmplEaEliEntteEst eReSTE. | IEEE EEEmEn ue ] EBEEE 15a EEEsEsEaEi gpm 1 ii3EES jE EBRREEEmSEahraas EESEmERE 0 | iEPEMfREREzSfEESsRwmmsIraRmmG:s, OpEE 23/08] ------ a pBBeEE sdCme Ww deen Bilract. Come ow Eo EEiRlEe gaa 5o5n BgEg Y uy BBEE mHE omOB BF HBL mEaamt EEE. BBEEcLLEmi omORB OogEminf LA (ekoef , BEmn EmENSSRS EW LL HEOED BE, | gBpEEEHmRn |i EEERnbmlamwmeeammmnss, mmEEESmRAE, 0 BB2Er LHm"ln omHoDm PRL. Eo mmEseRnRm omaR o.o rh I : | HSHEES I R BEEBE LSSE LEE BEER E EBRE HmERE BaL EwEerR OT 1 aE EEmammiGR BEBE BD BEE 4 + 05kul, 10 kes, Th Qladg cach chick sso wie cr + bracidd 7 temple Huth ] tovgo. Dako. 1s Ok ard is repebeble, ve orlosay i eins mo mi i 000579 : BEL BERESE. | mes, mommeme 20 120THO RatLiverGooge 3 3 -a | FrITaEtEer recfR em nT g9p esa sr | mJEES EE E EE REEE E =C= x Eoa EER 1 roLiiTnth E CEDEENE cEe IE fEHErEmMaEe OMTSiH mHHaEEmRR 333 1 I I i PO EEEEBRim EEnEe EmEaRn EuIme Eee 5 BBEE2 PEE BEEESIRE. 0 BF ie an eee ow ER 0S301 Meck Blume p--d --_---- Er Jnaiye a- 1] iIIuEEmS E EEnRzEE pmEsLaE amAYy. B=mE ! une wi men a | E IBEeE l IENaEams iltao Sols Eas BE=naE B..8 8B mm |, hEEEE DmEeSEEIeRsS, (OE EEBMEEEE,. iBFzRroo...H m Boa BE ammo. | BEEEEE: DsmoumnEmoRnME 0 BB F Lm LM #w1m mBuEmE OL | HB HESEEEE ERNE I EEEBiREElm Di eEeERee aSEs iien, PE CEERI E[ B BE[nERr oa uxe a 2: aun ou ` 1 IBI EENE E D EEE E IE R ag EE BERBNl aEw 53m1 gfBiaEtEb 3i% NEN IEEE, Roam EME mim oW ] adalinedli0n: quanaadtpriintet d 03a/08t /99eby ddeh 000!580 : |i J om a Lhe Gehepe 3 8 3 po pei nme, as EE we DESEE | -- | _lTiH--imE--en mEGEeSd LHEER SE SEEE RoSSuGE IIIe | HS({{tiEEEgirEESh B Ss EEiEaE sSme aaemR emse vL waena,n 1 EEE EEEERE sermmest act Blame ." 7 HIpJHnoDEaammEEe E S EES sRiuE SsEiE zmEE esSiVemS mamsnse, 1 3BRE5 GEEEeiEEEr TRS EexL1E20DSEoR . mmAEsDeT ,aa2/mn9. asDB || BppjpEEuoEEnnaREyy EB EBDEiRERSBR ERaMNeIE ZSsIaOaEE EasSEma | B gHHBuEEEI mREEsER EEDEENEEaETREBam GmeSLmn EmsS, | i HEE EE EEIe ERLe ED. GEE Ram 5 02010003 ER E S eeHa Tox120, BLOI-MLIvertlk-, 222/99 Ram ISHEH 1 5HffB1 GEoEaoiMnEmnaEdRss TE mEea sAEEe,MmRLE meaezeamesaE -RssmiovmE , aeaa-nmdM n,, 03/08fi ge B2 fmnec mom mine mw EBE BBEE=EI,RE O EmfpiE eE nE aoEmmGr EBBomIEaE OoBu EOE om daly "- ome pcuam 3 HHBiE JaEEEEms3i33 HE - E[- =mBR rrn2 em mn enw wm = EABaRrEe rm wer em EB2 2 E2o. as mi sem ow EEB E=aannr o BEEr . dEBarnEe ..ruam mo0m01 maE, ae ` Be iim dD fm od E SRHandaEOEEMOLReEE Eo1m8 OFOoiMraESeLnDs mmE mTuEEEmg3ooua |1 | ir ssa kesdSo A 000581 : V || A m-- E mE -- ..., eers |Correlation coefficient = 0.997569, 2 = 0.995144 |Calibration heft un | Core pe Fines,OarExctde,Weighting Nu,Ai as:None 1 4.8 : * ] . : he 1 1 Ey | | . | |e . | a 4 .. . q .. ~ 1 i | J oorectientrmnrmpee ! 00 200.0 400.0 600.0 800.0 1000.0 Conc , . 000582 SEiNStIiToIeIsN. = Senin STE |C[Coommbpoounncd2oneamfe:PRES= 099922= 0499884,98 R(esCponasetlycpueri:vEe:b2x0tr52e2Sar3d*,ntxAar+iel9a7o.3n922 | Core rp Linear, Orig:Fide,Weighing:Nol,Asstas: None | 24 ] : EY - |i \ . : ] : ] /-thCon Lo . n . Mk if 2 dol, Nhe pr Jy ha Woaflntcok .dsepl ("27tteaslly \| So = 2000 4000 6000 5000 3 10000 Co_ne: 1 imsns commtstnosnonnt 000583 1 Te eae Torresoa I || REpmrBmeim rari c ps n |Calci urvb e:1r .09a 344t *xi + 4o 4.3n 843 3 . 1 \ 1 : | | 1I Respond .x : $ 5 1 4 | - : | J| A Pa TTA Ta : TM _ enn -- i | sme pee : |Calibration curve: 5.2093*8 x + 18.1144 | BE ViighiegNull,Axis trans: None | 6.26e3- ] . 1 1 4 | ,| . | J: . q i . . 1 ` || ' | I i ei --or--wm edhe aby son10s0 >Conc. Pr " stun, fnmeneean. [Compound 5name: Telmerd69 : |Correlation coefficient: = 0.998530, 2 = 0.997062 \ |Calibrationcucve:0.565020 * x + 37.7497 i| |C[urvRetyepet:ys Lpien:ep Eaxrt,eoOmrailn gSint:dsE,xAcze leuad.e, WeightingNull,Axistrans: None 721- ] a 1 1 . 0 | . } J: 1 ; 9 - - . ] . J Co | x -- *% . 3. | 5 00 0 eho S000 Tae "Conc. | mcs samt sdeid 3 8 000586 V TET. ee = ] fryer rerio | [CompsamoeTuemneds - |Correlation coefficient: = 0.997982*,2 = 0.995968 | [cromopmEmisoet iieenns Calci urvb e:2r .28a 567*t x+i-1o 7.6n 540 | 2 ] ` :: 1 1 } . |: . ] J } ] 1 : | . . . - 2: i . | H| or.e rene sonar | 00 200.0 400.0 600.0 800.0 1000.0 . ERT res IB ]= | pommpormem . : | Es 1 1.416 ] 3 oe Co 1 IEEE i| ) ' ) ! J J : 1 : . ] . . | | . l : } ens00 e0i1 n02 a03ire 04 05. 06 07 | x : : x |. Bt i 08 09 10 000588 = | meu merrmmee : | wm Vakhe oume Ue oulahs | Integrate Window actors 1000 HEE, Emin J Em mm I pBrEaEm. E= jovdon |=eosin + - : sr ` | wEnms wm | mms co 3. : ] Aeopones messbeta jp BEERDEE BmEaEm " | . | . | | I 000589 ] | En, mm 1 Es ne : lama me | mee me Jom 1= 1 RpakoerTrtoma . we = B |=remain =T|-- | ENE. OB o . Co : , . . -- ST sath . . 7 1) FEaEm | | | | RhmEe 4 : . . 000590 ' Vn 1 Et, mm ro amin Mads ots - shale 1 Theoriewise rectors Tea = rENrDSAL =HE ] BEne Ean, BE | =Hevsionn A Eee. | .] a ] hii a) | EEnEiE RaEe I | . . . . : :. . 2 } } 000591 1 oo ] mm RE PEE EL 1 1 her =smn . Time Ln | me mama, We p EEE EER . | . | | | I N - Co 3. . . 000592 : =D | Fhe mp 1 ome = [I Bu Po IE re ] EE , BE |. . | . | ! | ' - . | . | 000593 J __ - commm rem sem ts -- tebe e-- e t -- e-- et-- er---- | ome msm | ==m eoer Compounds 4 Telnarses wl| . Js ST ImmEaEEmE. mIE ee | f HEmSm meee . ] E=m . me ' rl | BsmeEtae ir on || BErm. gpe ue | = oy em, * | mm xl ' BEF armm o . : . | | } | 000594 . | EL omen MethodRagart Em S mm I | =e. | BoEmE. E Sage. pes ] EEE EF TolmontalTre near | I min 0 |e || EEE tf | B20, |. mmm | Heme mE po |I | - ~ " ouve 1c osha) . : ' to ' " | . 000595 : | AMELIA062498: FACT EquipmentLog 98061 QuaItI,t#6r44o3E PAGE, . 1 DAT:E0S1659 1) 2liclag ANALYSTho:j | STUDYNUMBER tox120. MATRIX:Ratliver DESCRIPTION: _ionpairdilutions "FACT Method: FACT-M4.0 : 1 Injectionvolume Qu Cyclone: 35min, Electrode ZSpray "MobilePhase: (A)2.0 mMNH4CH3C02 (B) MeOH. ] To-A-orstadrdmumber (A) 98094-1520 1E Prepared (ately): (A)3169b9oi B)IA22S (8)3016/99boi . Expires: (A) 09199. ---~ (8)9/1699 ] Storeatroomtemp? [] or N Ober Guardcolumn: None 1 Putmmber.ma Lot numberz:a i Analytica clam: keystonebeast. : ! Size:25 100mm Typer18 `Spheresize; Sum. | Putmumber,__ 1057012 Lotmumber,PSHOB Seal umber: 204550 | Analyticalparameters: Io Drgays(Ukie) n 300g ESlnchugals(iUzB)i1gS Shegasa(tLAh) i LCFlowrate; 300 ul/min. Backpressu10r0eba:r ] HPLCsolventgradient:ong : | ai0s00 w : uo % | ap-s oe aus | 000596 : , . [J -- ib st-- n : pn | Mevthrods: aC/\vMAaSSLI3N6X\oRATpS2s,PRO3A0C88RUDE\PFOS ibm re : hea TE Rk f oi Hie . i iL i |i om | scoopmteirsany( mse-) ECxotnreactor ] RSDFoeusroLcelenvsatBiloonck TTeemmpp.. Dau 499.00 s3e0r0 m2a.k9 8s% e-0 120.5020 125508 uJ s HTMonReEsnoelxugtyion MuTLoelnntsiEpn6leiregry Ramp ] rreseures Analyser Vacuum Gas coll nase 1.000 a.se3 . ns2 H1i RReessoolluuttiioonn CoTTloonnliEEsnnieeorrnggyy Rasp LMLueelnntssip89lier s1e5r.0 mak 125.000% . 05s.s0o 6 set mak 1i5s.l0 F2A.0 oaWo0 3is 60 | 000597 : 1B ele Ce - [re | BEE rpBen | | } i: m: | ] : I | | Co on : 000598 . 1 pForsrlmrislorrm | SS ---- Lr Lt os 1 j{P PomOop beStseE rat LMoBatEBaReme ewmon ms mvwFneEeimmseesss DHmww8Bnmaonoo 1 [{{RSE0Bo31EER6E9EE9NM0Re08 ToLESDDxiE2HEa0R,RRRRmBERSLE0EB2BLR2L2ae0bS-Enn1eL0piREEpE2b2E2-SRER/28S,9 EEBRPFaaOoSEmmPlFeeHRSlssIS mB flmomnmg L d3 Tames mo ii5B goommomodaeEEesRsNt:mm CRhCmRRaReURemREEmEAmlERaeRIm,sIIiEEESEE npi naRaRmmmEeeeRssEl EmEl bbWum b4 BBE OR 1 iBomomee iPi19 omo0e3m16m9e9e0t19 TSRomScxim2RhE0aA, 1ET6ES5FO-SGsSiU,2E2T2im/U9R8,mTE2E5T0ee| mSaemee SPmFFOaaESPmmFoHaSeEIsS hmodd h Em loEng o d1o8n | ii2OiB ooEoBEmEseReE | EE S aE DmTRhReRi EeERmAe LEeRETmnERE| mmmBeneEmmRmEeEmeSse FREE BBobWHWm 2e8d81 HZ 3 ooGgoaEEmse mCmRERmmlfaEddeSndasTmt EEBwmRmeesss bbMuu d4 ] 3iE33f2 omJ 0GSSm3m1m6m0EEe0n32 e ToSSammxiRaaRR0n,Ea RaEEBEmaaLSOaiiZEZn maeZR-aaaI2C5nmmCR,02p22p/b99 mmLPPFOeRmSPiEFHssSSIEIS Emer long? 8 bbbBuo uLfo8R ia3inoBmSseieenEmss DmSpEBRRiaRREmTnGaRaETdEmOEmRmOaIeSUeRnTET pRSooeaEERnmmmmeeeEe:rls nEmer B EmbfERmRom R8823 ] 4S44 osSg0S31ee0eEE0ed004-8 TmobcSmizaEaoh,nemiRBdiLAmOmZEHd22mE9ea-ss250|ppb.2,C2C2/S0,9 mPPPPRFOESmREEPRTHssEESEIS kflEB Eoneemg?ofu283 EE 5E SB gn mC Y edi 51 031699051 `MeOHBlank mRmemsEi PFOS-PFHS-IS m mfmm k long2. 94 4 1 55 57 031690085 SgEER 031690057 "Tox120,RBL02229-250ppb2-7C2C2/B8,9 Dmiateesemesn `Tox120,RBL02229-H20BIk-2,2/22/99 PFOS-PFHS-IS HReEmSESl PFOS-PFHS-IS long2 88 BERR]E long2 1 i :55 SEE 031639089 BREESE Tox120, RBLO2229-Spp2b/2-22/9,9 PREe PFOSPFHSIS folong 3 000593 = ul on 50 8B810 ki2 BiB0i8 EESEh Hg88BB5EaEE: 188b80 AE%n 8ggBBEeEr LggBEaxE 1BBgB80 QxAaaC iBBBgaaaEa 1gg0 a84Ea iLgE hx Bi1L0FaA:r 10 Q 84810 A 180 88 : : BESTCOPY AVAILABLE A Page 2 | sompous comssonasaerosampiomasissehm. nd. | o8f gBBEeEEEmRMR DC DmEmAReRasR ammaaemmas aimeasnm nnDgueeenmmmsss m mmmmmmff| i38IEE8 | BEE Emma ER mR 3 | : | : ) 3= ' | |s 000600 1 FACT: DATA REVIEW SUMMARY FORM - [-- 1 Aw FACT StudyNumber J ee ] TimePoints ] Ste EEE) ) we | __TOX 120 Rob Liver Gb-pros, GS-PRUS ] . [Radyo d: ceptable LinearRage: 100for thisdataset: [Re-evaluatedfordifferentrange? 1 frit )analyte 1: 2hP.FsSo 1 lLOQ focthisdstaset: __ 5.99 ppb [Re ovaluistod for iff range? tl ---- lyta S: I 0Qfxtisdns 3Y vaste for diff || aeWL aegheld l-o cons sslsgs P | [oases 59% pb [Re-cvaluatedfor differentrange? No rE ] coeptable Linear Range 1 [eos |Re-evaluatedfor different [Se cmcepetabl Liffear Rang-- e: ---- [L0Gfor tif dataset: Re evayhid for drfange? __ . re Ls LinearRange: Voatwossune |Re-evaluated fordifferent range? J | Boke: PFos+ FHS oars infegpobed seporale) fered sp due o3lifag | . | 000601 i 1 SLITS TAT | gemomase |p meee 1m fai 1580 EEDE da GREE EEmEhaE Haima Ik WEEZEANR, CS - 0 ] BESTCOPY AVAILABLE ns /, Mee LE ME URE STnhee Boogmom om my EEE HEBER JR gis mR k= We eid Er san SSE 3 1 iE BLESEEE.. OF if 4 #8 WEE | EE BRASS RBimar Ikedivaae,sr ees Bima: Iie den aus, stess BF=4 oeedomc EOE EEE ow) 1 a inn Hatth HER EEE EO vm , me dl OS ERT HE i SiiSmEeR TSoEeM EEeEi IwA, aaR 0 uBaB BE SR Hm CaEn AHnEeE BESel JOR | p@WC oililat oo | J | tevo ct st onmn 000602 . 1 . ~ rT Co -- | mEoEmTsS emE en . | rts we ar3 303309000 | --T_--m =m Eom rm ee eee 1S8H8E SEEhE amE an Bfl Bi2z wom cWdIs 4wie5% 1 iEgEiR SEhiE maE naet B2E B OEE E BOB HHEE OHEEEi IE yn BOSH OW WE OBE J 1 EE Ente I HEE a EEsRm E. | ii Erdman PEE Bit yma = 3 4.4% #83 BBD em ow oma oe ow g mou x EI 8J VIIBSE B EiEoE s | EHEERR E ENR ET HO Bl wr EE EdBanmnn ] IEEE HE EER PEE EE ISEEAR | o@ue oli BB - B5y oOn Eam mmsE IiamRRoa Br Um om own tmp oa HB "EEE BOE BE HE dE 3 BOBS BR Bf mpd | | | [E---------- 000603 ; TRL. ~ EE | SEiinan, HRRETT HEITRE | (EGEacE ufrve:o47.rr 622a4+xte +s8oe1s9.sn668 | 00S ve Ear ng Echo,Weighing: 11x,As rans:None 62 : 8 ] . 1 . | || iI |: : . 1 J lo |. i| : | I ' 3)----1-- ) --Who , x : Co | | 3. . 5 500 T0000 - conc 000604 ] =n SLRRTEITL. | opimge.n, sDuEsTeER ReesbE dena mes I] 2a - | : - Ex ' 1 Lo | To Ll A : i | . 3 ] oo | 1 |.` | } . Sh 3% f |y ) | . i . fe a wen 0.0 01 02 03 04 05 08 0. 08 09 oa . 000605 | - = | =r 3 mpm oo } || . . | i 000606 - i in, wm [oo 1 | EE. | = mee T= ET Aube DLzvte " 1c cslialis ` . TT I :| . RE : | f . } . 000607 : | mLT mTm | Toe me | iimEam EEoiEmEaEnRaAaE y ii he B EEi REg at 1 (EE EESSE. iHEeE BDEiSsEoRnIsE | IEE Evan | BiEoEmE SBa EnEeRv Sde, | EEE ERESE BESTC,OP;Y AVAILABLE my mm = on BEoEReEr on 4ome BBOE BSE 4EE dBRi or oro aEReE d EEREs Lai BOOHER BBo... womOB OOEBRE BO BBY ern mn Be OBIE B EEE) J . own w | EEE EAST 2 "wm on ms mes. FFREEEED E EEEEE E E IR EByl mm 5 gm ogmm cn | fEEiE E BEEREENS EBB OBEiRE O8BB BBlE BEESL 33 | O@Ue outa Cab Chake*2 +#3 wine oullers, Wh all olhar CC str soibhin erika, Cal Checks will |ebe rapnidyaunedacwietghloobtehureuein dssalla sel do h whether or not tbhesy are oulliers. TP Confirmed,' {Taube mihod bor 338920 bese 8 pled whoBentns the 39059 chanel |I sesso tet es x tn a 000608 Coau EET : Ce ] ERLE, WRN 1 m_ reiTnao d2 2r 30m 13310m m wm me -- we ee-- ne IiEEpE EEdESEamayern E5B om oO@E mOBRI uBrE 3 GEE Esme a 1 GE Beams EEE OE mR g Hf i DoloNE ENR vas 3 mame mi ERS ny mE "4 1s 3 NER HEISE. one Tol dr A 48 AE 8 Tan 2s nm. | Go EEERIE. Goin hu ines vs BY em we en eam ay wow wai SRE dE, | Soom muERITH us | 6 veols | | [evn on sm t mee | oa Om fii 1 000609 . | EEE SEELRIIRIT | | mEiinm.i,sEeTmIen ] a ve Sesas.xs 77720 | TBe ae hoe : ude, Weighting: 1c As tans: None 7.81 | } } ] o . 1 . 1 . . | , I I Lo | . s .. 1 . 1 :x --= ' - ' $ . | . | | . ) eom3mb0mmonme0 6060 5 10000 one: y 000610 sms, | gomum, simaarmeon , TCompraTmneS i| Reon SemSu a Ava [ResponseFactor: 1659.45 | ae 1 - Co 1 oO of . : Ll oH ) = x o * : . . i : 1 ; ] . 1 : | . ] . % . ) i . . . . ] . oC | ans00c0.o m1 t 0tn 2mrnt 03 04 05 06 0.7 08 0.9 7 , 000611 LE prongiov | ES... a feds oo ) 1 EE FF =. i | a, Toe: +] Co J [id 1 EEE = ] : ) |. | | | i. | 000612 : EE | Ev... 1mm = | EEE BF r= oo ) 1 | | : | i | or . " . - 000613 | 1 FACT: DATAREVIEW SUMMARY FORM = | ous s/s [99 . ] Analyst: LEE. FACTStudyNumber ZOX-/(2O | fir bavge. ] TimePoints 4l-a5 |Asalyte 4: 15 |AcceptableLineasR-- ange: ---- oqror tisdsaser [Re-ovalustedfordiffrentrange? _____ Dilutions? NED Foe Pai 62453 ] I %2 < [Aaaty5a: 0Q thisdsr aset __52 gob T fe od fxdifferngs? 0Qforthisdatseat: Ro-evatusd focdifferntrng? | hR2 Ts nay 6: i coeptable LinearRange: _//~ SST get ceptable Linear Range: | [LoQtrtisdaaser 20% I oon ocattremgner [LOQ forthisdatseat: Re-evalustd fordiffrent fog? . J [Rast 25 eT ] JLOQforthisdataset: gob [Ro-cvfoar ilffueccsattraongde? || | oqso gil danse: a tod fordiffrent range? - " oS ] 000614 | = | mewm BESTCOPY AVAILABLE ] tv 8 itom | iE Ean vn mo - = ne' wo 1 ii Shea \ 1 1 sae I ERASE me 4 " un Tre 1 EEE BRSAE.. oa. iE RE | ie nha... mee owed I madeline 410901 quantitatedandprintedbysea3/03/33 . 000615 | Tir men ] . To : | . | J ~ ! x ] | | I I eae } 000616 . .ET ES NE -- phnvon a mE HHEEE PoBHdim | HEE | mm m mBnEEEmE RnSeRo EBnEENEERRIGSE EdEaauon EREERIE., on HEeEReR BaEx OAS HIIREHBOH BBEERD OBBEERRROR 29 oa. HOB -- on BOEMR BE AfHEsER 9a 4 BBEEEHE 2 un ERED GEE BEEERMD.. oa. HOE SEE : Bm iE mEmESEE oo. HOE BEE Shgprom won mm oar GdRaEmEm BEEE EERIAER.. . oa. d dE O SHEESEEE lewsdl \ REE o BEER I | EBBEEEEEE din GEE fh BEEEIME., oa. BREESE... ae EBBREREEEEEESSSEE, a. EEEELOE BERRANE.. . a. BRERIUE.. oo. B23 HtmOAfn im HOm BOOEB 3 OR HE SEE NmeNn AnEaFe OEBE gm ZHEuEo, gas BE MEE BEER EEE SiR BERBERS... oa. 88 BEER Bim BREEZES... oa. i GE BRAEE fi BERIUIEDR WOE EN EER ) J -------- .opoen? J | Bemis BESTCOPYAVALABLE g om me HEE ERReereans vn OF EEom o 1 To JLo [I ] ] | ! | Lieas smemesesomit oo : o . . 000618 | || p g ta e m a ~ BESTCOPYAVAILABLE hs | Be Bees onc somosog ] iSEE S Ehieemmme BE BEL2L FEBEEEMRE)J | HHEEEE GEE BELE ESES. ome HHEoE m EH BEEe. EEEEA.. oe HE ammmag) of | ol. Thames HEE EE ED eked og, : cme eet a 000619 Co | Emimmme BESTCOPYAVNLIBLE : | mm mn :1 . | | |o : 3 ] : I 1; essseems . i.. "000620 . 1 - . - ! SuamitySompiuedSwanySapert - ney | | mEms=LdeLpE meerRmmE ee ' | Em ETm EN m et EE SEEMERAS 0 EE LE Doin EEREIUR WOE EE ] ESEoEC jim EBEnEERESSMEELe ERR ELUM oRioEdOo OE Bp HHHEEE oa33 b|oi BEER CERES. Shama we HEHE dom MSN ome USES Ed Poona EERE SER i daline Ge169D quant tatedandprintedby men 3/35/98 HOW ER neo 000621 : i 1 ] |I 1 ] : ,| . | | Co :o. o oo E . 000622 : ! ERE ' || paorsom. gmEuTnEe--y---- | Cosficient ofDetermination: 0.989036 [(CRaelsipbornastieoynpceur:vEe: 1x .3548i S5t*hxA+mr29s.3093 | \ 1 `type: Linear, Origin: Exclude, Weighting:1/x, Axistrans:None | 1.5363. . 1I! . |i CL ts : i ;| 7 sl | /| J .| 1: || ' ' } . I| Res |i ? . Pa | / ; | J 3 J 3. i : I (3 i |i | / ] vo... 00. 0 : 2000 4000 6000 00.0 0d Conc: ) ------ 000623 | CmmmER i apo Determination: 0.991992 librwateiotnycpurevEe:xe7.m3a4l88S3ip* xAv+en1,17.484 | | vo near,Origin:Exclude,Weighting: 1/x,Axistrans: None 1 1I: Co | || J. J J . ); . oT ii i i| i| : ] A : 1 1 Il . | N i | A4 i ; ; | 00 2000 4000 mate en 6000 5000 10000 con wy | Bgiee. m SmTeIeTrH. . | (CocthelentofDetermination: 0.594707 [Calibration curve: ae * x+5.06533 | reFae iExc, `Weighting: 1/x, Axis trans: None 2 11 : i so | | I CS 1 . %. | [meme Zo | I: . , . y i Co. | . . ] .. | i . . Pod y 1 | | mma 3 matte Ststapene yn $508 ! mw 000625 | EE } I o | bo Co Lb 11 . } | vpoo pa co 7. | SE SoSL |: 7 : 1 yd | | / . 0 01 02 0304 : mp 05 06 ' 07 08 09 10Conie, 000626 ] me re J Es a . ] 1. be ; | } . + ~ : _ 000627 - Fe Burm oii tice ] sar pa i = | Bee ] : | Co |) } | | } oc Co : : 000628 : oli ] po Fo J , A . | . ] . | | SE : . } 000629 DE ile on cdl | pn,ene gins Eee a 1 EE 1 | | | | . 000630 i } 2/7 : rE 1 i 'QAuMEaLIItA,0t#6624r4489oE8.: FACTEquipmentLog 99016 PAGE_____ . ] DATE:042099 ANALYST:mee : | STUDYNUMBER Tox120 MATRDX:Rat Liver DESCRIPTIONi:p FACT Method: ETS.450 ] InjecionvolumeOWL Cycletime;90min, Electrode ZSpray ] MobilePhase: (A)2.0 mM NH4CH3CO2 (B) MeOH TNA-orstad mamber (A) 39012:522 eas 1 Prepared (dtety)y: (A)4169o9k )49159 bof , Expires: (A)1099 1 Pr-- I 1099 . J Gpuaerndtceolcuamnn: None or mt | Analyticaleotuma:keystonebetas] | ) Size 2x 0mm pects r------ | Partnumber; _085:701-2 Lotnumber;_PTL04 Serial mumber: 04811722 . 1 Amaiytcal parameters: ) Drgays(Uih)n300g__ ESTochugals(iUbz)i1Sn_g_ Sheatagas(URID__ ] LCrFate:l300ouliwn. Backpressure:S9bar ~ ] HPLCsolves gradielnotng:? | me-- : 24s os | 36s os ! 210 | a0 op | 000631 ii . | ET Mathod: ] Printed: : \MASSLYN. PXRO\\ARCQAUDTB\S PF2OS Tue Apr 20 17:06:38 1999 9/2/79 me = | =BE | CaSaspicllearry | Emmmemr a ranigcoar ema | 3w$.00du2,99 M08oEom na 1r6e0sd ri BpA ia 1 Resolution pTiyber oBimaisieesmstaatn FEom eae. Multiplier . sa - 1i5i.0 eto o sF5iAe0e a FFEo 650 000632y ] FACT: DATA REVIEW SUMMARY FORM | | ou 4123199 1 er bh FACT StudyNaber _TOX120 | Rut Uv 1 TimePoiats arp 4 ' = - ceepable Liver Rang OQfor thisdataset: Re-evlufosr edidffe ange? Ee Dilutias? I [a 25-350 EL a JLOQ fortisdataset: opt 1| [Ro-cvalust:ed fordiffrentange? -- id a [RE evatuated for ifferentrange? _-- i] [Ro-cvaluatedfordifferent range? En [Re-cvaluatedfordifferentrange? -- - 4 eT 1 coeptableLinear Range coeptablo LinearRange: ] [LOGforthisdataset. L0G forthisdatsea: [Re-cvaflorudiafftereendt ryhge |Re-evaluated for differentrange? | Dituhms asguuinid Chmogrepiey . | Nad na-ophanizaion Yr -- awk 40 l vcccptaPbeloes,sinuokthc.onde bc bebo | bi #122055 ! 000633 ] _-- EEE EE own dE J! | | : i i: | Tse et sn stmn - . 3 : 0063s me | fErTp N SETVEp RE cL [I ------ libration curve: 3.73294 * x+ 36.9502 ee real Sa A + type: Linear, Origin: Exclude, Weighting: 1/x, Axis trans: None | i 3.773 i / J| | Ii . | i | 7 | | : x 2 : !| oe J I . | . / I / : | .: | i }| ; | S od A%o 0 0 0 0 fr | 000635 ] . frew--r"y | sSammplseListcCAMhASSaLYNnUats2 PROVSamplaDBIOAZ0806SPL ] Flotame FlaTest 1I5 EoDimEooowoEonzs TMYeeooomHaaBaRtnBakLnOsMoDmOaIoNHnBaiOKac,Sn, 81 SSSiid3Bods0sseo0cror TTTooonurRRaRaaLLLooosSsTsioooppisihasos44as10es0s0e000 7S do GDCiiddoosm sescotmo Oi20e0l1 TTTooeuuiRsrRaBiLLoosoInOsi1I0mmOig o4Sv41nai109vl88Se00 Toxizd.RBLOKIBG-souNapGDOT 1I13 BOiOii3oGe0eerR000isEiss NTToaooxruottnztRsoo:bBNlnaLBn.okLMOmIMtDGOGa-Tn1So0ma0E4b4O1p0O0RT8-0 I1185 SSSiiiBkBdo0saocoocliisrc TTTooouiasRRRIIILCaaavvMoOoffr... nanraoommme i13 OGGisaEomosEle TTloeiwoaansRRaaInLbeSrMsOfs:aoopdme4c1O68n0 25L SOOooeeemsacciassss TTYoossoooARRTaIILLoTaws..oOnooa,annna.,aam | 323054 5 OC0C4io2oom0s0sem0ci0is2sa5 -TTToovwecooanabiRRRxaTaInLikLibOwMi.02aGS1.v,024/sn15b,s/o58oph.4010929,0 I |B B0 3 GCShERoRmENa Coes TTT oeiai moimuo .om Ofrn a4nna 1e9om TorsoRIL 1: on nao 3$ 3 COCiBoCooemBcsss Coens TohYxeoiozdRbAaLnbkAt1w0.6caosubnpampeb-4C10639,0 Tous RIL 1 oz nas | 33S7i OC0i4Bs2oo0es0s0mc0oo3ws8 TTT oouio s RRRxTIILCL.2iS10iMhM,:2GG222.0a4n/1ae9,/ds50 0836 OSCiioaodemsestdasieta TToloeaoanBRMaAnoLkooAm10,SS0a2bp,P4CO0H,AOD 44 C CoBNRRER ToT aramnoRmiu sae m ooSfxva4a nenwonese &GGo SC30u0eE 0s0.0 TTMoouerisennRRIsbLtaseomns.oaosxp4e1n0csos 41a | 8a DmmBmS 5 SEES TT moeRo mInLaaor aCohcFaa nienas | 55BESDlEOoaMSnEe TowKreioEnsREaanLusioseasubemme-040106,0 5 Oise Tori RILSa o340 35FQOile dooemmocess RTT Cous RRo IILLIonu uo3x4s aoneees ] 505 0C0H60E06E0 TT oxiz0h ,RALOHTSG-250ppO4-1C9C/T8,0 roy mie B Paget : usr MSSNMNCNCOCMOOBMBTBTITSSSPPPOOORAMAA SSSMUNNNCCCOOOMVNBEHTMIISSSPEEOOOMMNA MSSUUNNNCCCOOOUUMBBBTTTIIISSSPPPOOOMAMAAL SMSMNMNGNGOGOUOUBUBTIBISSSPPPOOOMAAAAA SDSININGNCOCOUOMBBBTTTSSSPETOOOAMMA SNMNISCNOOCUUOBBBMMISSSPPTOOOAAMAA . SNSUCNNOCCUOOBNVTBBIMISSSPPEOOOAAMAA SSUUNNCCOOMBMTBITSISPFOOMM SSMSMNMMICNNNOCGCUOOOMBuUBTIBBITTTSISSSPPFFOOOORAMMAA SSSIIINNNCCCOOONNEEBTTTSSSETIoOOMM NNDIGGNOOCUUOBBNTSBTSPSPOPOMOAAM SSFINNCrCOOMiMBBTTsSSPPtOOMM SSSSMNNNICCCNOOCouWOvBMBEBTTImIITSSSIFPSrPOOoORmMM. SSBMMNNNCGcOOoNUuEBsITmSSSPErOooMAmA MSSIIINNNCCCOOBNMTBBTTSSSEPPOOONMM SN BgINNSeooS ounMSBTTcSS SoPesOAM MMBinNNCccooovuuassmmmSsrrrooommm MNBNNNGCCOONUMBBBITTSSSPEEOoOMM NSNGGOoUuTmSmPSOrMo SSIMNNCCOOMNBBITTISSPPOOMMA etFle Botte amssmmmnann 91 32 mmSanm && osSmhmn & SSShnmh 8J111o. mmmnna 111 SSsmmmaah 11818 Sssmmmaha 91isf mmSmnnin 32113 mmmnen 8B822 mmSmnaa A521 sSmmmnna 8 5 mn 2 mm mSmnnin ao22804 sdmmmnan 3331 mmmann || 338 sm smmmaha g332 mmsnnmn:28 msmmean sma 8 4 msmmiann 4a7 ) 000636 1 - Masslynx -SampleList - [I Samplo List: CIMASSLYN ais? PROSamieDEOAZ00S9PL.. 7/22/99 MEE Page2 1 Flokame FloTex sre wtf Botte | @ oC04oo2wa06on%se08z:3 TouTTs oRoRRIIILLLxxA3306dtiMMu,,.Gzz33,.400n4119a9.,95d00 SSMMMNINCNCOCOOVMUBBBITTTIIISSSPPPOOORAMAA mmoiiminnn i4ss G66 OCiCisiOooosoddceeessr TToouuTitozsxDdiRRaIIMLLA44L21BMM:.At0033GG44-10S0Sm0ipA41C9D9,0 @ Oissoea Meowblank SMDGIININCNNCOCCOUOOUBUBMIBITETSISISSFPPPOOOORAMMA mmominann omin 44i8 8 T@Go OiGizs0ooos0oeoo7ere 0 Oidossors T T Too RRIIud LL..zdd4oesa Dhh.,,.G0033, ,3R.,44, 141I010908L000 TRIo C47h G3a .410m MDUNNNCCCOOOMMUBDBIIITTTIISSSPPPOOOAAA osommmiiinn a8o UNCOUBTISPOA omin 8 7724 OOGiZdo0o0ems0cTsrSs YMoeuootdnaob.iAaKTnBLkLeosA.1Oos-,250opmpeb.40109, SSSUMINNNCCCOOOUMUBBBITITSSSPPPOOORRM oimiimnna 688 ] TT7ToP5a CCC0ll4iso2soo0mee0me0odo0rr7rre8s TT Toutos Ro RRxITILLL77iSaaGu MM.:,zOG53S,.,044s 41199.a/909 ovisRIL ro. o, namo MSMSUNMNNCNGCOCOOVOUMBBUAITRMTIMSISSPSPEPOOOORAMMAA ffOmmmin on T7&i0 72 8i73 GOOiiisBroosoosncoeont:m ToTMuoesuob.tlzaMnAoLk.osRtoIsLCss.5b47p17R9bM%C,OS41990 Oisdsooms TaxisRIL. 7a.05. 41090 MSMNMNCNCOGOVOUBUBBTTMISSSPPPOOOMMM ooommmnaa.n 575344 MINCOMBITISPOA omin i || 588 OODlwbino0oansess 8 Quaooer TTYooMoexuoRdnboRlRlaIinbLkli7to0MoG,bGI-3-.sz4a1sia0eRppdop4oo410u1s99S,00,0 SDDNUUNINNCNCCOOCOMUOMBBUBIIBTITSTTISSSPPPPOOOORAAM ooommmiiinnn min 87 % | 88$1 C00i43z20D00o9o9000008809 80 OAO0001 TTToooTwxut1it2ssa0DD,..RRRRTIIILLLL,..oo61vM3b.,M,1GOGr1--213s20-0p5p0p2u Mpp5SMpoDS0b:,4M-p/4A4Mo1191pSSD/a9i,9b%S,9H SSSSMMNMINCNISCOONOMMUGBBBIOIITUISSSBPPPPOOIOOAARASA mGomiiinnn Sma n77 @ SS1i 51 OCOiiix0oooso0os0sc2is C2000 TTTooMuectooonDab,iRRuRaIBAnLkLL.tO1OA3DNMsG.I-OOZT.SO20-5p0AHpL2pCb0OHBiS4AoD1.,0e491090 SSSMMIMMNNNNCCOGGOMBOOBTUUTIIBBSSPTTPPOOOIIORAASSMAR fSSmmmm omin 8@@1 8G5 Si 0CCiix0E0ooo00S0s0nn Oliosscm TTToToxootuundtsoss..RRRRaOaBLLOLAotIOMOoM0DttOOuoOep2]iAs,Nsds441Gie11asa0An0D%s,,9DD SMMMNIININNGNCCCOOOONMNMBBBIBIMIIISSSPPPPOOOORAAMA. * Goommmiinnn din 432 : O9o O0i0a0o0e1s0i0o TToowriizD,HRBoLLo4O1HEOsGSt0opnps,,4a1O6R0 ] 110012 O0u4Z2000009I100R2 TTooxuit2s0.,RRBBLLOOAIMOI02O5O0.pp8-01,044p/1p16b/80.9 SSSUSNMNUIICNNNOCGCMOOOBMNMTBBIIRTSIIISSSPFPPOOOORAAAAA odmmiinn SSimnn $8 3 1 110038 OCiIdoEeIoi0oEs TFoouitz.MmBaLLoOsMioIsB1OcT0S0ODp4Om41R1e0A08r8,0t0 SMSIINNCGOOMMBBIISPPOOMM oommin fo i1 | 000637 * | Messy Sampleist || Sm MReect `SampleList:CAMASSLYNX\rats2.PRO\SampleDB\042099d.SPL. |i File Name FiloText 1[3Cd21 00Ns4422a00E08m0911Es0078 TMom IecOlE2H0B,lRaRs nEkLROSIRh SO-H2ui OBe4N1s-91A9,0 5 NE0E42Rm00E9m1L10 TILI ooxi2R 0,r RBeLOi 41l99-e 1e0pdpn4l io1a a-1am91s9,m9e 5ILSEEE Iem eliVina ] Hh BBo UEGRE bESmNe ITe MoemilS raiissaoH ews.soTneaS noe,mvdiieane Bota TRAmaM Sie CB1LT6 ooUt0SM4m2mE0E9mnE91EEE2R1 TToxom1i2N 0,ERRTnLI ,ad51MSw,oG4ke,a4i/d1ec8/s99ewers leah BBnE ooMaoEmR EnENeE Mk amSmAEme saw.eso] hiniasmm BBBOoOUoRSESeEEmS II loeA onc e loShhi owiscoca.i arom iLE22%398 SEuammmm: 004422000099113343 TTIeammAA-C eovChhh iieme wes ``TTooxx112200,,RRTTLL,,5601MM,,GG44,,44//1198//9899 IEBNOUmMRERmoIemola usam onii csrree ] IF B36 ON0044c E22000R0911S4412 `TLTR Toeoxoxi 1i122R00,,aRRBBLlOLe 4bO19Ti9-S5iOpp-sb1-e 1s0,p4s4/ap1/6oi1ir/89m-o/m88m,e9n 1 Fi tenea SOMERS RCmRieaa tenSaReEpt diRina]lms RNRRNR. ofan)39 meg : Faget e-------- MSFile : Inlet File Bottle 1 lloonnggs6 "3 3 looooneeggs i I oe . loI onges. .f8o& looo onegg8maa56 E 0o % --.8 o bogeee a88 llooF oI nngeg8 I. ]4685 o-oee ou lloone bnneggs6e+ Sd483 I g 0%k . 0R3 1} | 000638 1 - Masaiyns-SampleList || `ESaRmpSle rN List: CMASSLYNXvrats2 PRO\SampleDB\042009d.SPL. FL em 1[5121 00GC44ui22u00o9d0i00i11oo00ss67 78Gm GCCiiammgmmesiiiiilo Qlounils IR 11102 0GS4: l2e0Ue09i1Nl1s5 r 1135 OGiir oeobiizao 1T17o0 OOOiliaoaomosammiiizzzsas B5R OCiifoodmaiiszss 32BG325 O0SOC4uS2u0Som9a9EiN1as27o |B5 GCiowia 29 30 004422000009113345 31 3BS52ii 00OG44o2200Em8099i11D33s67 Gizooio ] 3S3i7 SO0iiis2ooma0itisasz 3W8 CCSUiiBolniiEias 1 4 CCCiiEboeRllNa en TTMTooewoxOi1H2za0oB,lRRRaBnBELkLOLAOIoAO1MOSSGp-oOHo2rL]ONB44G1I419k1K00-9m.T910,. TTaTTTxoooioadwzaadR RRRRBeBBLiLLOcoOAkU MIMGIGSGOiI-D 0oL0eRm04444aI M01N1rO00iO0Aa90Es. v`TTeoouxo1tn2s0:,bRRBmBLLOO4A1t9O9S--510000p0ppbe-01t,,4A/1T6E/8D9 TTTouooRRuIIIuULC.SsisooitMbzooOfskk.oaa4rnn..aame TTToooMuureittoasanhb,iRRRaIIOnLkLLOosAaaIO,.boG2ssbd.pa4ptbia-onCeOe.Y, H1E0 T"TTToToootxd1ua2so0l,RARRKITrbInLUL,hass5eo5a1ioMwws,ooGosf4fak.,044aa/pnn11.io8pao/n50bs9.0401029,0 MYeoomnblAanTk sou.oh41am ``TTooxx112200,, RRTTLL,,6621MM,,GG44,,44//1188//9999. T``YoTTeooouoxxio11n222,00o,,BRRRaRBTnLLLkBOo,461Ls39M9tO,-G2oN45,o0Dp4ap/bB1o-8C/4Nm9C1934Gi,014c,a%/1,9/89. TTTTooooxtitd2a0o.RRRRBaLBDtOAaLLTOOOO.Mf1M0OpepOOo-t.Lu,44tSAarie10isS9sOpee9T| TTTToooouuxRsoRRRBaaBLLLOOLoMMOsORSoOS1oO00z0M00s000a,,.Opa444mnnRoGaanRm.Oe Teak else ohm,anos iid meg Paget Gore PPPPrFrrBBoosSsS44 bPbrrrooassss Pprreoscss PbPPFrrrBoooSsss4. PPrrPooosssees FFrPrraoogsshsi Fprroossh PFFPBrrrFroaBoogSggs4ss PProossee PFPFBBSS44. PPbFFFrBrBoSosS4g4.s FPrrParaogssa4e FFPrrrooessshhs FbrPiroaogcgs fot rn sats lloogenngsegs. o231n ee=ee 44 = me Ire [ong=g6 B91 Gow ngegs on8 nnoggssse e@85 losses ngeees w88a0 lloogges 88 lloonnggss 6 8 llonlononggggssss 68837 diononngpgse 23i ingggs 887 gn nee. S81 re || i 000639 1 | RT es | mpmma 1 aT -- Es | emma eri gn eels ] : ] Tm mee ] SEEETTTE | Tair ] Lome | t 000640 . || wr | nppltge 1 FE me Be on | mTE E So VEE | PL mE ET | : 1 : Er pL ERE PE ]1 . 1 } . ] ! Gae/58 mi | 1 1 o I: | | | ~ . 000642 3 : ] | po AMELIA062498: FACTEquipmentLog 99016 | QuattroI,#6443E 4124/95 mee ~ PAGE. | DATE:0422/99 ANALYST:mee | 7 SrupyNUMBER Torizo MATRDXat Liver DESCRPTION:i | EACTMemeETSE50 | InjectionvolumeJOuL Cycletine:13Smin. Electrode:ZSpray ] `Mobile Phase: (A)2.0 mMNH4CH3CO2 (B) MeOH TNA or sadedsumber (A) 99012:522 Eda 1 Propared (datelby): (A)416/9/o9k (849/99 bo Expires: (A) 10/99 (B) 10/99 1) Swreatroomtemp? [] or N Otter: Guid oan: Neos | fp------ Lot number; pa . : | Analytical column: keystone betasil | mem -- - | PSiuzet:m2mxbeSrO,mm__0g57011_-- " "LToyptem:anl8ber_PTLDY SeSphemrme bsiezer:OS5umL712 \ . ] Analytical parameters: ! Dryinggas(UA30)0 . ESTnebugals(iLii)1n5 g Shgaes(aLR)t0_h__ ] HPLCsolvestgradient: ong2 po EE 2 nas . | 3 ne So @ | ous sop | 000643 ' | : . AMELIA062498: FACT Equipment Log 99016 Quattro II, #6448 #2: meg PAGE_____ -. ' DATE:0422/99 ' ANALYST: mee : i STUDYNUMBERTox-120 MATRaRtLIiveXr(pf:bs) DESCRIPTIONi;p | FcAiCcTlMeetghotds:lET,S_._850 Cyto15,Beco Zim ] Mobile Phase: (A)2.0 mM NH4CH3CO2 TNA or sade mbes (A) 99012:522 Enea (B)MeOH ] Prepared (datelby): (A)4/16/9o9k/ (B) 419/99 hoj . `Expires: (A) 20/99 (8) 10/99 i cnt He Storeatroomtemp? [or N or Oer_____ | Part umber; na Lot mumber a ! Analytical colum; keystone betas , Size: 2x 0mm Typeislt Sphere size: Sum. Pumnber__ 037012 Lotmmbor_FILM Sei mabe 41720 A J Analytical parame: Dryiaggas(Ui) 200__ ESlocbguaal(UsR)i1oS_gSheathgas(LO | LCFlow rate: 300ulmin. Backpressure;S9bar_ " ] HPLCsolves gradient: og? : po Th ime maia)e-- omwa |' 32) 5n0o 9ss Sos | os sor ' - | 000644 | | untng vosnod sepoze | Mpertihosde:s Cm\ASpSLIaOa\R2A60T3S52120FR1O0N9A9GUEB\PTOS | TE re a RR RS ReNLR 1 Bn A SER PL eD AS TORR RE PREY 9/r22e/39 vege1 we: osfuls 1] n TEEB S aieT E |e i Eh Tdha LE |e some (mee) | JExtny--rac--tor SDeosreTeiovnnastBiloonc:k TTermpp.. sor mak n1$on4Te 012.33200 1152 ; Bl BESTCOPY AVAILABLE - iJRRea--soleu--tion iiiootninpFsntetreery nase ser mam 121550.00% is$o s 1 seme Rak |xaGnaaslycsonetr acum 2.004 5.503 | sz E14nlRRieessstsotluuttiioonn Son theray WfLeanaoi'sti1 piter a mak f515e.d0 a Fo $to 3 J 000645 } ! - Massiyn -Sample List - || PSeimepldeLTihsutACpArM2A2SS1L7YN5XV0a13t9s8120PROISampleDB1042255.8PAL.ree 0 7/24)39 mE - Paget rola | FlaName FloText ws Fi | 423 00022020900000000213 TTMooexuOiTzoH0o,,BRiRBnBLLkOO441IOGBG--LVHBIKO-B1N,,441919D ImTSSaUNnN 45 C02i9000000i5 8 i908 TTTooocxwTi2a200,,.RRRBEBLLLOOOAAAIIOIOOOS-SS2p5p9b0t100,pp,o1, 4401106G00 SIiUNNN 37 GGii2aee0o0nr 3 Giamed0s TTToooxxiiiaaooRRROBBLLLOOOAAIAIOINSO--NS2-O51p00op0nmGt-m,T,4A41N19GG0RRYY [I 15MIN IBN 111120 i0Gi46a2s00a6002l10 TTToooxxxlit2aa0dd,,, RRRBBELLLOOOA4AI1TO9GO8S-7-SS10O00p0pp0pDpD-m1To.,-t44A119T5D9G LdIInBBNN ] 3ii38 000i4iz2za2as0oo6000ii1ss3 TMToeowOcrHtaz.B0l,RaRInTkL.409MM.. GG44,,441199988,0D1I0O 111888MUUINNN i118 0O0ii0zz0e001it7ss TTooTxxoiixzzi0zd,0RR.IIRLTL.L 5SS2IOMMM,,.GGGi44,,,4441/19189905999.,. DDD110 Ii8aUnN isn 212000 0G0i2io0g0e02n1s00t MTToeouuOtrzH200,,BiRRaOnTLkLOHSSAMS,-2G540,p4p109.C5C91.,D14100100 ITISSSNNN || 222542 OOGiiizzziaooooo0r0zzzszs TTTooouxiIia2zddd,,, RRRIIILLL... 5sST6oW,,, GGG44A,,,144/1/11a9as91099.., DD1100 IIIRRNNN 232675 O0Oiizzia2oao0a02z7s TMTeoowOxrHaioalBlRRaOInUkLOHsSaS,-2GaS.0p4pi0a-eCoC.E G0 IIISRBNNN |i 22590 iGOiezioeosnese0 TTToooxuliaizdo. IRRTTLLL, GGSiAolMM.., 0OGdd4,.. 4d411r6aa00m.,. 1Tis8aaNNn 5$3125 000i4a2zo20o0on0003s3t23 TMToeoxtOiaHzo,,BlRRaATnLkLOAGo1MS,S2G540,p4p1bo-mCoCY,, 41909 pIIoNN 533885 G00i4iz2j22ao0oo60s0ss3s TTToooxxtTT2o20o,,,RRRBBoLLlOOoAA4TI1SOoRRSLnoHBpaoAtO,,BlH,4114GB01O0a JTIBUBINN 333307 0OGiiz2zi0s60aa3y0 | TTToonowii2aa0,, RRRBBOLLLOOOHAASIIDOS--OS1Z0oS0poPd01b,n,, 441111169919d09 III8BBNNN -]1 240 O0Oim2ze6o6n00:0i TTToooxxixzo0o,, RRRBOBLLLOOOHHIA1SI9NS0-O1205S000pp0ppoG0-111,,, A4411O199N09 ITiBUsNNn 1! Y4U CCiz9aoe00ss TTooxio,, RRBBLLOOH4OISS--1T0S0OERpGpODA-,,4A11090 iTsSnN IniotFlle glotgiss lglooinggistss llooggiiss lllooogggiiisss fllooongngigisse lllooonnngggsss lflooorngggiesss lolonogggiiisss giloonntggttsss llgooniggiisss lllonogggiilsss llnongggiitsss Tggooigtsss lllooonngggiisss olonoiggiiess gts Botte o1t 243 6 078 911110 111432 111873 1119 22210 8221B4 222387 + 91127. 432 &87 8910 | 000646 i | Masslynx -SampleList Boh `Sample List: RCAMsASSLY0NX0\rat0s%2 PRO\SampleDB\042298b SPL | FE -- 13 1 oiOoimusese Olsson TTTMooouuexRROoORlHLooOLsNooOvsSHoaSooaLBp4A1ii4nOKc10R,arT0m, SSEEEEEERNSD Gms | TTTloooowsmmaRrRraooalloloLwwioo0tOmo0mnssigoaaoai4ngnroeg9eoseset%ss 1Bfo To OoOldibmEsosmossR:s Olas TTTE ooxiRoz RDE oBLLoLOuGOSzOR S0sHOm0RNEcEepTOE R44o4101-O900T0090,0 31154 16 GiOliosmmseocnssa Gime TTwoocceaRdRTsLTiM C2o nn, aamm lows RTL ioWGE nae I1io 3 EOGiiEbdsEeoenSss Cimmees TTT ooxiwzaR RRIBo CL2iBmI.DcOaOsa z-aasnwnieoednsspp4C10O8H0 eonSiamk 555 CGCiiemmemsoew llT oowwss RRRo TILIzaodc wU.oGozE2Mnna naaa.mmm | 33224 CGCGiiiiobzzmomsmooosonss -TTeoloaoTnnRRRxTsIaoLLl,z2iOo5uHu,zGoG.2sF,o84n01on9p,m180s9.040150,0 |IB205 0GGM4ii2gz2mmaa9Eow0ii7as2 3 Olmos TTTT m ooowuwstsado RRRa RIITALLLLx 32OS70Hm MMM,SG1 GSG22E-,4442e 110 0899/0689p39o400180,0 3E 33 OOOiSmdEmaEiNcrSi i TT eoaonRo AsILm] vac Oo.na neasm 1 3SWTh OOOOiimizumedswenrets T TeoloTannRRo RoIsIALLLSuOIonHu MuS,:aOS03-0.42s 4110a,apmmpbAC01T0,0 4 & CCDiiEzfmmEmoeNss TTooTawoaaRIzLnssRooTwuoo.0s3xsaa4ennnguooee.nse DG G 48 C CCGIiEs s mN0e0 |. TTToeooxowtwarndaa:tRRiRIInBLLUkOaNawInO.H0205330p4apneo0.OsC8,4100 | G 5GS0 OE0BiN EzE0SaRs TToo oudTiRARoMIa .La caeaVmim.,o CoGoz3sk n,o.a04w gienese,ssesee | 5S8 oDElizEoiooSwos Dion TTuR ooeucoizana sRReBnLOOm LAIOSNo O-O2Oan iLpNpGbBe -R1,CD0CDN,D SSo imSOoEiNoniaini & Sain TTTTooowuomaRxRRaRalaLOolOLisooSoOwpoeoTNoesi,sOboTaipzoOSnnaoogeRDttss @ OB ToiRBL0O0 HO410S80 | ! 9/22 J33 ms - Pag1e c -- nar soe MMMUNNNNCCCCOOOOUUBBBBTIITISSSSEPTLOOOOMMNM rrlinzzg lng 313 3 MITUNNNCOCCMBSOISMPPPOOOEMM lllrnrgg 3 TIm MUMNNNCCCe OONSIBSInPPSOOEMMO.. llo8oonrrigee 7 IITMMMNNCCNOOCNNBBOIIMSSPPPBOOOSMMM blbooorrngggzzz 139111 TTTMMMNNNCCCOOOMMMBBBIIINNNSSSPPPOOORMA llloornngggss 3332 IMTTMIUMNNNNCCCCOOOOVVMNBBBBIIIMSSIISSPPPPOOOORMMM llkoornngggzss longs 835482 3 T3MTMUMINNNNC-COCOCOMBMBBISIIIITSISSFPPPOOOORAMAAA llooggss lloonggs2 33 83 IIMMNNCCOONUBAIMSISPPOOMM lloonngg2z 8552 1TTM3UUNMNNCNC-COOCOMMNOBBBIIMTISIBSSEPPPIOOOORSMMA lllgooonggzgss? #4444 ITIUMUNNNNCCCONCNBAOBTMISSSBIPPPIOOOOSNMM foloonnggizz longs + 884388 48 MTTIUNMNCNCCOOOMMMBBBIPPPTTIOOOISASMS lllooongggsz2 p4473e MUUNNNNCGOCOOOMNOBBBMMISBSSPPPIPOOOOSMMMM llooneggs2 tore2 888 81 TTTMNMNCNCMOCMBOBIUTSSBPPPTOOOMSMM. lologogzgs 858 IIIMNNUUSCNNOOGGUUOOBBTMUUSSAAPPPPMMOOOOMSSRMM. llgoorgzgsz logs 88888 3MMNNNICNS-OCoCMOuBEMBBIITTSTSISSPPPPOOOOMARMR. llogoernggzgss2 5 88 M MNMNNCGCN NOOMBUBC ITBSSIPPPS EMOOOMOMRS. lglloorsgggss 3341 NNNCECMOBEUTSSSOPTOOMMM. llnroggz2e 78 000647 9120/08 . [e re-------- e - - PEE Pogez `BSaimpeleListKCoArMASSLeYNOzNat0s020PROVSampleDBYOAZ2580 SBEoLnshe DL2v1s IAC o5/iofas &o6f |Iw2&a ] w7n | 7i FloName EOomomaoisros EEE . FieTet TTTooot,moRrRBLeLOoKtuISoGS2Su50Rs0T0c1,,aa441ie1oo9net0e TRRE die :. ; sie Iti Botte 1IIM3MNMCNIONCM-BOCTOVIMSBBPPPIIOOOTAAASSR blrairgg TMNCOMBITSPOM lor 1110 . i , . i |i ! 000648 | EEE |EEnor SE n hod ScanningMethod Nagert. [EEEEmonens [me mmm | Fh we Bes mein [=r PO LERE en | Eman BEET Bn || EgEaE m Baeno Yl2e/98 PEE . moe 1 us ueorl : ] 1 ene mes oe "- " PEi ER Bn een eeE s mE mm : FEEEY Binens } 000649 } ve TE 1 TP Bm ] 1 oC | ro 1 1 | | ] . | i . oh : Co 000650 + | | EE {md Set 1 i BEER OB * i 1. | To | || ] . 1 : ] : |. . | ] . | : a ve wood . o : oo . 000651. . ] FACT: DATA REVIEW SUMMARY FORM ~ 1 ow 4123199 . | Ae bh Raat FACT Study Number __T0X "120 | AcceptableLinear Range: | Matrix ] TiePoiats Hale Up's Grvp 4 [LOQ forthisdataset: [Re-evafourdaiftfreendt rang? Dilutions? Some ant 1 wm (FEES) aly 5: 7 OQ forthisdataset: Serle [Ro-ovaluated for differentrange? _1v0__ --- 1LOQ forthisghta set: IRo-evalyefod Bc ifficatrange? B -- OQforthisdataset: : i m3 T S/o] |LOQforthisdataset: Er malyts 7: | IL0Q fortisdatast: 0Q ris daa et: ! | Doubtsposh i chown bat pean inheqruted Deals 0k. ki 4123/19 | . | 000652 ' 1 FACT: DATA REVIEW SUMMARY FORM _ ] ow 4/23199 ] Alyse bh FACT Study Number _T0X-120 | Matrix Hale Uver's . Rada: |AcceptableLinear Range: 1LOQforthisdataset: EL | Tene Dilutions? 1 par Gomi. Some and --a oT | Thien |oQixtiisdmmser ___SEPR | fesisn 1LOQfoethis tn st: EA | Ite 2: | cceptable Linear Range: |LOQ forthisdatseta: 1 Fes: T q | Accptble Liver Rs [pr 6: ceptable Linear Rangg: S/o |LOQforthis dataset: eT: cosptable Linesr Range: | : | Debt peaba chavma-,botnpeaba infegqraked Detals OF. ki 4123/19 ] . | 000653 : | eee TT I amen I . J 1 ] ` | . ] | | NalinGURLRavioued1nd quantiCAtedBy Kh 4123/90 R - 000654 : ere = | (Coefficiento. fDetermination: 0.995565 (Calibrationcurve: 5.97710* x +7.52572 Ee ree, `Weighting: 1/x,Axis trans: None | 5.9863. | y 1 1 1 7. / : Jo y p7 :| 1 x I| ) , L| 2. | 1 ] | Co / . | li : ) ) | 7 Fb Cone | tnt e000 2000 C0ADOT Gobo CT svbo0oess 10000 | ] Ee : Bh) | || | : !: | | . | | : :. ~ . 000656 . ] SOUP020199: FACTEquipmentLog 99014 PAGE C QuaItI,t#6r414oE ] "DATEL 05/14/99 | ANALYST:dib . bSIN 4 STUDYNUMBER; Tox-120MATRIX: RatLiver DESCRIPTION, dilutions FACT Method: ETS-8:5.0 | Injectionvolume: 10ul, Ceetime: 9.pin, Elecwode:ZSoray 1 MobilePhase: (A0UMNHCHICO? BMH TNors- todrA dnum- ber (A) 99011:6-0 - INAS 1 Prepared (Gately): (ANQARESOGD one ) Expires: wis as 1 Storestroomtemp? [or N Otter. | `Guardcolumn: Nore | Putmmberna Lot umber Analyticalcolumn: Keystone Betas | Siei2sS0mm TpeClS SpheresizeiSum -- Part number:055.7012. Lotnumber PTLO4 SerialnumberQASUISZ : |1 Drgyas (iUhen);3g50 ESIncbguasl(Uihrz) i1Sng ShgeasUa0th LCFlowrate: J00ul/min, Backpressure 55 bar ~ | Tihmoe(emin--) -- &m B___o _ 2am wo | as sso aes smo ] n20 400 ] 000657 . | | rontos sarnoa aeporee ee non 1 Hatnoa: [E---- | setacees Fri May 16 16:17:39 1999 0 14]%9 [4 JEST COPY AVAILABLE A = oh z = | somer (mse) | ECxocearrpetaicttaorry | EDSeosusriicveatBiloonc:k TTeemmp.. se na $ 3a".003k2,s98 30G.002 a1me ws T44onRReEesnsoeolrluautytiioonn MLZeolnntsEinpelrigeyr Rasp se na 21i6%s.'0,2 aEER oY ] emesmuces nan Analyses vacuum 3.305 Ges cet cae i | 52 Co1LrxlRRieesssiooollnuuttiioonn ZZTeoonnns'EEnaeerraeyy Ram Wteintsiplier se na 1F1E530.00 2o&%a wo o 650 a 000658 : Massiynx-Sample List 1 PsrianmlpoiceuFsrsMacyus1s4s1s6u:1n7o:2n1ea19c8r0.s srosampieosustassese 0 Pago1 IN. 4 - FloNam: FloText MSFle inetl Bot lume SampleT ConcA Factor! | 21 cG3o14nas00e8 mMaooHBmaank TTEIEMERRS Osninn 9s8e 1100 AAmnaabse 3 Goiasooe TocizoRBlostooho4OB1k929 TELMERS amin 41 10 Anabe oooem Fe 3 0G03S51i14i40o90o00008e8 TTTooouxw111222000,RRREBBLOLLAOOIMASOI0OS-L1DeB3-,p4IS4p14co1o01Zo0r99,9sb90,9 TTTEEELLIMMMEEERRR:S mmmiiinnn 4428 111000 ASSunamaniiadsraa 4S3700 2F00e0 2%0 7G 00551140000008 TToowx11202,0R,ROBLLONSOOo0pA-o2tI0,o44Op11h96D25.00 TTEELLNMEERR(( Onniinn 4488 1100 SSuannddaa 426438 523%0 J 103 GCcBSolIt44i09s33e00o77eToTTxooi1css0DoRRnBBLeLOOAuMIcOOcShSiOeEsSts00u0440on110D00a2s88Zs,99 12 Gliomor Toxizo BLONOSTSbE4NGND TTTEEELLMMMEEERRRSSG ooSmmmiiinnn. 44497 TELMER( min 50 111000 10 SSStttaaannndddaaarrrddd Sundard 274043975398 222005%50%0%0 31348 G0G5So1tl4dd9ss0oe0mm7nTTMooaxioizhzhB0lzRaonBkML2O/0N1o2sIo401mGzR0 ETTELELMLUEMERER:RS oOOmrriiinnn 5$8128 111000 ASAnnuaanbbdttaeer 078 222%3%0%0 11176a G003S311tdsisooa0o0r0rToTTxooiwwiizssdooososeawhGooaaa///DDDiiizzszs TTTEEELUEMEERRRS ooSmmiminn 83542 111000 AAAmmnaaabbiitsee 2255%% 25% | 323110 0EGG3SS1ti4di5Ess3aa0nn7ee TiMTooeucolRihBBzl0Lma3On0cemAGGam/ODS1s2RsOPROC4O10Y8,9 TTETEEELLMEMEEERRRC Eaoammmiiinnn 5E 6&0 R111000 AAAMmnnaaabdttiaes o32o35%o%00 233315 G(CSi1idi4sa0edn0eeToT TuiozDoasxoemwmis i0GG3aaz/DD0o i1iioz2ss8 TTTEEEDDLUUMEEERRR::S aSOmmmiiinn &8810 111000 AAAnmmaaabtniooe 222555%%% ii 2355672 0(0G53ih11c44i9a0a90n00en80ToTTTxooou-i11zw22n00iaA3o8B2wMGLG0G3oaO/4/NDDDo1iOi2sMSs5sSAPPOAC1OGRRO TTTTEEEELDDDMUUUEEEERRRRSS:C SOGomrmmiiiinnnn- 6886253 11110000 AAAAnnnnaaaalbbyintteoee 0000.55200%%00 33510 00O5St1ii4dc0ge9en00s8n TToaxoorzd02ax2mn0M1GG2a/5/DDEii0t1o0 TTTEEELEMMERER;R; omSimmn 66G775 111000 AAAnnnaaas 32255%0% 333353 000555111444900030000888 TTTooxxo112200xR3310BMMiLGGO222A//DDOiiO0ttSooS0PL.4O109H9,0 TTTEEELLMMEEERRRS: mmmiiinnn. 7@608 + 111000 AAArnnaaabbbieea 7 55550%%0 353576 00G55S11t44d99s90o00088nMToTo1H2o0Bl4sa2oinkMmGG3za//DDi0Itto0 TTTEEEILEMNEERRR;S( mmmiiinnn. 767172 111000 AAAnnnaaaiisss 3423%0% 1 433309 00B55U1144G98E9901D80 TTT oxo12o 0rs44e75cMMn GGGi333/,D2ODi T:1I010O0 TTTEEELLMMMEEERRRSSS gSsmrmiinnn. 777438.. 111000 AAAmnaaatoo 30.050%0%0 344 G0055111644B9099I11000TMToaoxOiHizBlRAamBBeLLOOHNOONOSHRZGOR4B1O4K9C192O990S0 TTTEEELLVMUEEERRR(( dmmiiman 97481a 111000 AAAnnnaabaisa 020%%2000 43587 B0G5U1EG49E9DI1D0ToTToe1xn21i02s0,RRREOLOONLOLSLSEOOBpppZpMs,s,H,4A4ON1G1O0I0>080 ETEEMMMEEERRR ooommmaen 4##828 111000 SASnaaannvadewadn 547503 505505%0% 44089 000555111444099999111100TTToooccx1ii2zs0dD,,RRRBLBOLLNOOIMNS0O802O025A,0404O401011M2900b5,8Z099 TTTEEEMULEEMRRES:R ooomrmiiinan 444887 111000 SSSauunnnaddwaadd 243407838 055050000 | 853)2205l015i4154n09i011111ToTToxoxi1xz2oi0.sRADBBRLLBOO4LTOMSMO0O-IT5SS00OO0N444M01n1D0b9oGS.9%NE,20eD TTTEEELLLMMMEEERRRC moOmmii 45408 111000 SSStnnandddwwarddd 274433883 000220000000 8 TR EL oeus name TELMER: om 51 10 Sanaa 978 0% 000659 = rl | BEEBn we Tome | gfe 8 : | rm" Pema |. . ! | | - 000660 . ] FACT: DATA REVIEW SUMMARY FORM ~ ] Date: 05]18] Analyst: dvb ] FACT Study Number oY- 20 | mai Lot Liven Time Points EER | Dilutions? 1:25: Jk). 1 bl: PAR 1 coeptablo LinearRangs: S--7SDpth [root tisames foo LoreShp ] Re-svalusted fox differentrange? = | nalyta 2: M03 ! coeptabls Linear Range: -- AO STD % -- * JLoQrdtathaisese = | IF luted for differentrange? 1 nalyte 3: MSH [Rralyes 4 i coeptabloLinearRange:_~/)0 STU -- [L0Gforthisdaaset: = [Re-eox daiftienut rtangde? _-- orn nil coeptable LinearRange2: 5-70ph L0Qforthisdataset: Dob [Re-cvaluated fordifferentrangs? alyte 6: ceptableLinearRange: -- 0forthisdst set: -- [Re-efvoardilffeuresnt traengde? _-- . nalyts7: 5 0Qfor thisdataset: ZZ 1L.0Q fortdaisse. ] [Re-cvfoadlifufersnttraengde? _-- Re-cvlugted To different range? :| + oordCdS l the 10e 0 1s dpCpSm 5SsTStpadt | fo M563 Melon's apeimddy [Si cons | rdthe feunlt found Pathe 62 Draswpli01 2 : are Q e- pe hoshsliy A 661 0006 \ || p EEmTs | THe EET Ooss8f Ey vom mee ] || BESTCOPY AVAILABLE | o 000662 : | - a Ta ww Sr SL 1 mms, pesmi PoE E EE E am . -- os Ce 275/39 18 BEL ery Bl | dBEE S ReEaE s BBEEoma SEE EN EREERC GE BEE BE SEE EEESIRE LL. BR a. y| OEIEE EESEEREIE.S ..[oBdR LL 2 BE8E2R Ion BEER FREI gE IE [iE E in Cromer BE |opIEEnE EmmgEaMmeEnSeURn BBE E 548 5. | BIEEE E EErRm E BBRE 4B2s ] . | . | : || I I SO 000663 k | ET bh ! SETI Mm | mpmmm TE FETrr 0 mm me mine . Wm a Haii m mREsiRs m2e E i EI SE If Fi Sha aie 6 asm 0am i bE ERLE Er ame SES ae aie adem ! . i i | . i ! ' Soup 026199, Reviewed and quantitbaytdeedb SAT/00 . 000664 : ] i - | EsEaEE Drs SENT Sm hod | ema os] 18} '| Te Compound 414563 mE - Hg mmm HE Sree 3 J 1 EdiEaEnE EE EEEEELR IA.N EEgBEay wwtoof4 n EE wOE - E EEE EE EEEAY g2d2 1 pam SERAim ET me ' Ramm RORINaE/ fi ie #0 RE k | BEE Eigse 2 GENS SUH REE Gun, | REE BEEBE 1 | | | an 4 BOB J | i{sem setrt . 000665 : ! wT | ppm mymes memen | mm Eine mes DEHTOERR ' = : 0% | TE EET gg mm Fer et SR A jEE EEERAE BE &SOOEE Eek 3 LL. eee pag mmmarEn f= Do HEE ERERaAsTm EF mem om me mes ou ] REIN RomiGe un, WER BS MW oN Nn 2 ] | | | i | p. sn wr pases a pn 000666 * \ 00000 a iol 1| iEa EET eee Ey ve Tom mm me phnowmmeamaiE HEH IE HRB HWE MR 2 Eee 5H Eihaian 2 GEE Eimear EE SEE mms UE BER ] SSRN EEBNE sum ] ] | | B : I BOB BE BE 3 mom omg oD o3 MEIN HM mE mi io OES mR 7 . : 000667 } 1 = SENSEI at | a Caattbgeatieons |e H$\BECT-NLe ARu I be : || [C(Coefolicnt mpoundofnDaetmeer:miPnOaAtAion: 0.994079 i i [C[usrpvboernatstyeipoetn:yLpcieun:revBea:re,1mO.rai3g3i0nS5t:d*9E,Axxcr+l5eu8sd.e5,W3e5i9ghti|ng: 1,Axis| trans: None 15 B I ; | ; x } x i 63 : ] : I 1-%hConc In ': 373oy = 2000 4000 6000 $00.0 16000 Cone ad 000668 a sun -- 1 sEimIi pRmEyRmEemR---- [CaCliobrlatoionn ocuFDrevec:rm0i*axai+o0n: 0.000000 | Se TanOgio Evcie,Weighting: x,Axstrans:None 1 1 ] 1 | Resp | i| I i: ] . . 3 : 1 : . I. ! | BE | 1. Conc [ ; on 000669 0.0 1.0 20 3.0 4.0 5.0 6.0 70 80 9.0 10.0, cs amss , ana e em. | BE REE Compound mae: M5 oeffofiDecterimienatniotn: 0.995881 [RaelsipbornatsieotnEycpxuertveo: m0.a91l50t19g*Axre+a4.05752 | | I type: Linear, Origin:Exclude, Weighting: 1/x, Axistrans:None ! 1.023. ] , . J |1 217. x ]I ] 1-%Conc | x . .. ~ . nes s : i 2521, | 0.0 0 400.0 ee can,Bron 1cs4t 40 Conc 000670 ).0 800.0 1000.0 I . fire . et | sme vEvEETE- | Rp Ee Sava,Weighting: 1s,Axistrans: None ht 1 1 Ce 1 Respor ]: . | | | 1. ] ] I et | | | -1. | 0.0 1.0 20 30 40 5.0 6.0 | FE ' 7 Conc 0 8.0 9.0 10.0, 000671 \ - i smuum a ET-------- | Domne RIUSRE EN | [CocSthotpnt udofsDaemet:enMtoion: 0994865 [CRaelspiobnrsaetionEcurvxe: 0t.S4rd5*a Ax7r+n1,4.8566371 ) | Curve type: Linear, Origin: Exclude, Weighting: 1/x,Axis trans: None 51 i . . . ns I" i | | ' i 36.5, x . : -%Conc] x ! i i : . . x x . 215 7 0.0 200.0 400.0 Se 2, nero 2emtia48t4n0 Cone .0 800.0 1000.0 I | EE, | [Ee 7 j 1 1 : | | 1 - ]1 le] || Fs . :: :: | : | ToT we od os dE or io ih ) am 600344, Yoneda quiaetwesbydh 4/29/84 000673 prop Tm eet at E = m. ZB. : ENE... [--. stein -- | ssmnmam pure |POpEn L. = BE scot J--y------ .38 [Eorh i sii Ems Be sie RR os D| oEmEaEn dBbuammm Of x - TC oxofes . .} . } : . . 2 | 000674 ol | EE mms Ow | E.. [I~ -- BE 0% po RE ] | | | | i : ) : 000675 . Een ] EE. BE | EEE Ee 1 Emme zu = TE flys . I1 = uo } JE ]- 1 | : | we or ~ ) 000676 BEE -- rt Sah EEE Be . raEttNeEin... | EEERRI.E. Ee ilE m nas =e Ue osfao)gg } | cEtmiomnecums ar - | H mmam, OgEe a Lo `Soncantration . Top sito [---- oe josey | mn . | h Ere ma ma. : 25. ] ] . | J | | " i ! 000677 oem sm = ila GE oofav]sq ] Emme fr To : | meme | me wm ] . I | . | ] i . EN 000678 . SHE EB | en EE UC orfaalzy | Em we iL | Ee go | Ee = |, E BEE aBmE ] . | | i | } . Ce 000679 : | Q`uaStOtUrPo I0L2,0#169491:4EFACT Equipment Log 99014 PAG0E 1 DATE;052199 b: ] | 1 | ANALYST;db STUDYNUMBER;TOX-120_MATRIXRatLiver DESCRIPTION:Diluions Telex | FACT Method: ETS850. Injection volume: 10 ul. Cycle tim9emi:n. Electrode: Z:Spray 1 `MobilePhase: (AROMNHACHICO? ~~ BIMOH TNors- tudrA d num-ber (A) 901.62 INA2SO | Prepared (Gay): (NOUZESRGH (BOIS 1. `SExopicresst: momemt @ w ow iNe Ober . @0e ~ i Guard columst: Nose ) Patnumber:a. Lot number i Asalyti`cal column:KeystoneBetasil : i P---- Typesclt spied | Part number: 055:701:2 Lotnumber:PTLO4 Serial number 481757. " > Asalyticalparameters: i Dryinggas(UB).350__ESTocbuligazsi(oUhg) 1S Shegasa(Uth)h0. 1 LCFlowra3t00uel/m:in, Backpressure:S3bar .~ HPLCsolvent gradient: Smin2 i Tmemn) &B nog "0 | | 210 40 EYP STS-- 49650 80 | 10 we | 000680 saantteessHaro RepestSSLTE\FACE- FROACITR\PPOS2 ets ret vay 2 26020036 2999 CeEERE RINE 1 | I | 04 or ir fat 75 BEST COPY AVAILABLE | us soos (2p3 | | GocEeoyenpieer STowI merree:. us2 a Fs8 3aaana 3M1M | eresmuses san smatyser vaca aes cent 240s wes 1 i wf1RI Rraesoieluseion Ton er x1w5t2eesoohteucrtionn ES In Ts Lens & er oo nmn 35"ao5epds, gtot e fe max F1205,i.0, a%e 3 3 000681 | BESTCOPY AVAILABLE | | ar Garp sti GAASSLINXPACT PROSSTHOOBOSZISR SL Ss 1658 rot Foto |b13| gsEdmmoemmomosrsn ommor wrcyMeuomnimeawmmkmoaomsupeoemcoOdRwuLae TomiiGei, | 3PooEESEnmionbomonenmr iESEheEn | TT BmTeooammmam mrmsesm ossa mluaea leene iiUldis eti0Ehne, mEoRmEmEsEimeRetiSe LB3i omhaomhhmememeemmm i Shem mOmTommoouoaommpmsmmemioiieoieSelosdlicoeseEe |[BBBB2EooogEomnrimeReeesE TmN[Toaooommmssal ocanuR h A o BBl BBosoGmoomheweeeesmemn Mmmmpmoomemaeulnieotieutn ' | 2338 GoEmmEhieeemmchimemmom Eoin TMmoEEoOximmmUaomS,RsmeEBLemn0sonetesede250pp-0401t9H89, REISER. cove #o@ omER memmey L Tofmommmame--ii.ee | EiI El EoEmEmeeEtRn: mmaB, ie omkmeemnsMGofEeEe y 8f848ES0RE52hE1m9eN91miE15 `Mm TMeOOiHUBmlamnkm smoEmm R, Geee |Ci B55O832E S00mmmE5522hm11mm88emm9911maa1a290 EEER om ommommimamm msm mRseis seamiio nlm iAseHdm,e TTooxx--112200,,RRBBLLOO44119988--2150ppppbb--11,,44//1198//8899 CB ] 0 po 70 Js : OT TuTorem pmbeehz:on8on -- Dg10 oommawse bTTTTeoaorrermI Te gmfg mzhnonuoooRHnomlDlo aossewswaa,enn HTTBmioEEemm me gmgmEemnmromoooosxwR gn ow okno0Seemsee 6A Tmmmeeee He gg mooonmnnonngoom8o8.o0 mBKRBeaeA.e TTHTi meEm gggommmme oooo og mE mm oz 8Bime Bwniimnm TTTTamEEm oagmhegmrsmo8oo8wm BniRe.ea TTmWmmEReeEeER HE ooogogmgsonemnmgenowoow 1o0wn0 R 16 Bn0 oRAmn.e Sn oz ka mTmmfeEEEEct ogoB soonmmn Ro2oounn n3 knaann HHmTEEEm goagsmmmmonooownx 5 THimmEL-EPEEFI2 fgoomminmne2 o9ooww8n k66AA 10 Analyte TEL-PF2 HmHHHEEEEE TEU-PF2 oSomsmommomiinnnnneo22 ouwo888o23wn 10 Stands RRKRBEEEEoNR 10 Stand WE mn o8 0 BEX 000682 | | EEEmm | es . . Ot pL mmm PF TERE. TERETE LL. | 1 ane me em " i || . . 5.. . 1| ]. . | . . | ; 000683 FACT: DATA REVIEW SUMMARY FORM Due 5/24/93 Cham kh FACTStudy Number _70X20 |e Dut Liver: jmTime Points G5, ] peer FHS coeptable LincarRange: 11 =[1/1 Prk. I oQurtistenss Ulpub | |roonmuettcaatmet ro ) . aalyte 4: ceptableLinear Range: -- 00foc tisdataset: Re-valustd fordiffrent rg? a cooptab fog IR evaluted Range: fo diffrentrange? ; Iyto 2: " f nalyte 6: ! [LOQ forthis dataset: :% |LOQ forthisdataset: JLOQ forthisdataset: ] Ro-cvaluatfeocd diferent range? | | | | 0Q for thisdataset: e-falnated for diferentrange? . 000684 ! Fr TT 55 Ie ol ee loses 200 TT | 1 | : ! | : . ' 000685 . = ler J] | ] + | | J ! - 000636 . T=. | Bae TM po | | || | ho Co. . 000687 } -- Boum | mim pen, |8 a a, 1. ! #ne TM | BEE BEE I |] | . | !: | Sous 20088 [AC 05/24/98 | : Co } 000683 . [Compound 1 name: PFHS (CoefficientofDetermination: 0.998344 [(RCeaslpoinbsreatitoynpceu:rvEe:x1t.35e8S9rt9dn*,Axar+le-a1.38506 Curve type: Linear, Origin: Exclude, Weighting: Us, Axis trans: None 15163 ]I LL : ' i . RE i 25.67% - ] . 1 x. x 1-0 x I . | x 266 1 00 2000 4000 oC Cx : z 600.0 Cone 800.0 1000.0 - 000689 sm-- -: es [[RespRonseeFtayscpteo:rpE:xt5eo8r5n.anl5S5ds,Areea (Curvetype:RE A? | ] . x : 1| Respor | : : . I]} 163 } fn | ` | | x Lo ~ ja;x ; . i x x | oi er 0 0h 05 0s 4 di ds io , ms 000690 i ,| QAuMaEttLrIoA10,6#264498E8: FACT Equipment Log 99016 PAGE | DATE GSI 4 rang ANALYST: ho, ah : | STUDY NUMBER Tox-120, Tox.026 MATRIX: at ives, monkeysers DESCRIPTIOdiNl:. ) FACTMethod:es-M.50 1 reneonttnmie sons maze | Injectionvolume,10ul. Cycletime: 9min. Electrode:ZSpray Mobile Phase: (N20EMNHCHICO? (B)MeOH 1 Popa (chy) (NII @w Es w ] Sota? Gx XO Expires: (1 (8) 11/99. \ Guard column: Nooe ; Pact mune.5a Lotmumberza. i Analytical column:keystonebetasil - Sie 2250mm Tes Sphsieze rSuem | Partmumber,_0557012 Lotmmber, P1120 Serial sumber: G38126D 1 Analytical parameters: 1 DLCFrongyamsi(isL/h3ns0):0g3u00pin BEiScIknrebuc l0gaisz(L/ibrn) 1g5__ Shegasa(Ltn)h0 1 HPLC solveit gradleat: 9mia-2 | TPimaes(min) a ! 210 u . | 326ass s5s : ar oe | ne0oe . . 000691 1 ag SCrlag ~ | TuningMethod Report Page 1 ! Mathoa: C: \MASSLYN. PXRO\\ARCQUADBT\PSFO2S. | re Te May 25 15:22:53 1999 | a ER 0000DO 0 e Se a VS IE.BRT SrSh=E aa CO ES ECi r URE] isREsE Se ele CoER ACR PRR 1 wada s 23 ESS a | El i os | sovRcE (`EsP-) | CCoaExpntierlalcatroyr | RsoFurLceensmiock emp. Desoivation Temp. Set Rak 3s 1.300s2i.s98 03.02 150 30 25 ed Analyser Vacuum Gas cen | Rane 1.604 4.563 ust 1HT4tonRReeEssnooellxuugttyiioonn LTeonnsEn6ergy Ramp Multiplier sz Co14l4lRRieesssiooollnuuttiioonn TToonnEnEneerrggyyRamp LeLennss 9 Multiplier ser mask 1512..30003 osl a 50 sat mae 1155.000 320.0 a6 "0.0a0 osso | 000692 | A MassSylre-sSa(maplgeList l- Paget FSiamrplaeLTiostnCa:MyA2S5S1L5Y1N8X1y4a1t9s025PROYSamploDB0G25080.6PL - FloName Float 3 1 0eomos00st lmmeoetctahmnaamnioobinaannokkswekt 1 GGGoeedooss timooawaza mmmooonskioiooGoidmtGhoeett ] 7 fSo GOGosaiszsesesoemselsoser ili1ooaxo1a2ms0n,mmmioo0o4sia1os9no8zs-its2de5the0oeo9mt1tt [1 GGGieellnss llioomaaammmemmneogssieio-oooisTiaaddeopemettt l14o5 OOOBimBel0Elss 103MM lotmciaodcaMrokaort-a2s50 bpooommse,d1A0uRnD icin110Lg1200poomad,22000 1io GOBemotlss l xian o 111060em9311.22a 5500 pbooommsem ,d,4222200000 1 25550 0BO G5i2m8a9em6n0n2o0 1i0mnKca1i2v0a.nm1a,oOn1ia0nk6nFoo_sgs1s.42o51p0ep9peo9ec-dtm0do,,222/88 33i 00O3e3cc%hm 3 Oo lliooouauinss nlBoaoawuoogsns444010%00. m41s11000..000000 loisdnh sowge 410m, 41000 LB3 OOogmmsewenm 3 Cen loocmrieonmaaobnakeosni4p1ebme.stcto00 loin ng angess .aio |B30o0s%m loeiiss osbaoies4d1a0sss.a4l1o00o0 I 33T 34 OGO05im2so50s eo0ls03es4 lmi1omo0cexdi1i2a0, ib,OoaSiONnkMk-iSgeBZs,4p4/1p1a9b/e9e08s.,cs4t1o00000 W33 0DOi3ieo0on llioonccwoanssSdiuku oee 4A4e n1n9o090.,Ras 61ls10o00.o00 GSS O 00BSi%aoeu0 GQ Ocom mimmeiamnmai onnaoo zeamnoucse sas s meas iouions .cs ] i&s G OSosatosoaoonnis | OStmotn eww1e2ii0,gnh 2ai0og0u0se2s,dd1i1ao89ne8.,a022ss5 emia ssaias2s 5DG0 000i3BeEosNiEs O82 OSes tbmoearmmnmaionnmsasispaemneozeott waa lowesanaw 5S5fo00GOO%o0moso0osesss wlmmaoaizzam nzoalowooiwoussssssdanainnaiaoosmnssee |BG TGEG mss o CBE mSmaemasmommnasmosismbeec? ia moses us Fie nit Fils SSSMMMIIINNNPPPFFFOOOSSSPPPOOOAAARRRSSSIII2ZS8SE1NN3 SSommmiiinnnsgs SSSMMMIIIPNNFPPOEEOOSSSPPPOOOAAARLRSSSIIIZSSSSSN11S33 mmoimiinnnss GSSSMMMMIIIINNNNPPPPFFFFOOOOSSSSPPPOOOPAAAORRAASSSRIIISS3SIS0SS111333S Omtmimininngsg mins SSSMMMIIINNNDPFFFOOOSSSPPPOOOAAARRRSSSIIIZSZESENN SOommmiiinnnssg SSSMMMIIINNNPPPPPPOOOAAAEEESISIIOOOSSS0SSSSS113 mmmiiinnng . SOSMMUIINNNPPPFOFOSOSPPSOOPAOALAGSSIIISZS0SS1N31 omSmmiinnnzg . SSSOMMMMIIIINNNNPPPFFFFOOOOSSSSPPPPOOOAOAAAARRSRSISSISIISSESNTNNS3 SoSSmmmmiiiinnnnz2sg SSSMMMINNNPPPPPPOOOREAAAFSSOO1IIO22Z88SSES11S33 mmmiiinnng SSSMMMIIINNNPDPFFFOOOSSSPOPPAOOLAMSLSISIZISSSS1S31 MNrOSPOARSEIN SmInimiinnndgg omng SSSMIMMNFENNOSPFPPPOOOFrAAMSSSOOIIISZZ0SSEErS3 mmmiiinnngg SSSSMMMMIMINNN-PFPPrFFOOOOSSSS-PPPPOOOOAMAAASA-SISS1SII3SE6SI1NSS3 oOo9mmmmiiiinnnnsgg2 SSSMMINIPPNFFFOOOSSSPPPOOAAORRMSSSIIIZZESENNN OOSmmmiinanzg SSSMMUIINNNPPPFEOFOSOSPSPPOOOMAMSISISISSSSI0I33S dGmmmiiinnngag SSMMINFDOrSOPSOrLOSMISZISS OSmmaa OSSSMMMIIIMNNNPPPIFEFOOSOSNPPSPOPPOOAOMMNRESSSST11IOISSZ60ESS1IIN333 mm9oiimmninnngds2 SSSMMINFPr rrooSSPPo FOOOAMIS$S SI12ZE8E1 Ooommmiaana SfSMMiMNtEPrerOotSSrPPOaOMAtSRdiISiSIveSSteIN SMINPrOSPOMSISEI SdSmimaeadsd Smins SSSMMMMIFNrrFrooOSSSFProOOMAMSL1I1SSEa8IrS MNPrOSFOM SIS dOmmimnnnzad Sminz | 000693 | bh Slesle Massy SampleLiat . :5 Fae? SSaopea Lote ACMASSSLAYNOTs2 PROISapleDBI82886 PL . FlaName [ |8 B0UfoBEcsEEmawSSer |B8aDfEElNeEeE ] n6oSSEEEERR FleTex ioxuSCtiEamRRntosoRneutmEoEaseboiSedd ihmSuimRimEmooeEsmnRnREaoSrsmeR SmmEmoRneRmeEn usr atria SISNNNNPPPFEEFrOOOoSSSSPPPPOOOMMOMEESIIMITTNEeSSSn mOSbrmemiiinsndgs SDSSUIUNNPPNNErEPOOEESSOOPSPSOPOORTRRAOAASMSSIEIISSISSSTSTTSrSS gfffimmmnssss SSNNSrPOrSOTSOPROAMSSIISTeSrTSS Smmnid | : . | ] ~ | : 000694 | CC3 5 (2s(a---------- BE ge ere Ean REFER eee pram en 8 . CE Becei i | mgm ] EELBi min aL= C 1 Sem mee re ~ mat nhar bai se) ult ony om om (3 PEsee Shar biten a ae (oe C7) ] : oo - om " 1: || | :. | . : : 000695 ' FACT: DATA REVIEW SUMMARY FORM fo ST2slag Anslyst: Lod FACTStody Number_ 29%20 Manx Time Points | Dont Fe -- ws ] bya 1: ois cceptable Linear Rengee S=J 867.414 [LOQ for thisdatseat: SSep | [poovatued tcitfirmtmgr 2 ' } [Raalyis 4: 7 corpable Linear Range: JIE -- 0fortisdataset:__ S5411h [Re-foerdivffraentlraunges? _t/ed . - bya 5: Meptable Linear Range: sie i | ez 77 | ceptable Linear Range: 23-6 = FEY ! OQ tisdataset __2FH% mee \oL coeptable Linear Naogs |LOQ forthisdatseat: 1 pr 7 1 coeptable Linear Range: 5.--51/64 OQxtisdenset SIE26 ] Re-ovalusted fc diffrengnst? _ | . | J | = coeptable Linear Range: 1.00fo thisdeta st: [oRe valfourdisffrtentreangde? 000696 : ESly -. =. EE i BESTCOPY AVAILABLE a Em ENE Hp mm | EEEEE EEEiadnees BEEEopBE im BoEgiRY ] HBEiE SBEE EOhiEhEeE esendEmeaEn EERRLGEEREESESAL BHER RE NwEm Wgommse a OLEE fRBEIBRT wold 1 gE ERE te. BE Biome tei RLdew uiwes, sees f= ] 5 hae nsSadat Eo ame son seam a RES I mi n 8 f= | BEEEEEN I EERhDsMHnniviaveyseatses MEobRis saeen 0 atnitns | E EEEREBERGSEaIGnE jE EERERARS ] Game mH oe Tn 8 HEE Baas am iE made iE fame 1 iEEEE EEMEERRE EfmR re Tsoen gs Ht = 8 EE Me wLoamman RAE Joe ve esfalss Boman mune oc Be mE a vey EES en BBEEE OORGE RE GOF HAEREE GZ3 J mrisunrise sw { 000697 RoR :8] Slr fey EE SEE , THmE :- == BESTCOPY AVAILABLE ~ gy vn me fae SEE op BE BEE [EE I 1 H itae Bimmmmecn ea nase 0% vo Romie BPEL a oH mel , BEER BEDEmEES EE HE oEReT | HR Bom BE. COiEE Eiimeamas BH if Rd fei aan my aVs N 8 mine pam SEAEH FEE SENEE 1 iad sides | SEEN SH Re ER HEBER BBE BE in man RS NE jue [gE 4 AoEmum od | Deniin G614341 quantiated andprintedby hey 3/20/90 000698 : | - sam mm | Bmsenn, pBEoRema. o7r" e | rm semua x 13% | -- Tg ma _ I ---- IEEE EEEMERIYE EE JOEEE EM BE | ine aaa am = CHIEoE EEiRsaEi g82 | Ems mmEaias 8 I EB CES o8. re 5 a BoiOs wood uw om ER OE ows ui iE o8 EOE wm om I BRE ee BE im og ogm om | BPEEES E EmER siaG n . BBEE LLBPORROBiE O=Z y (EE BREEN BE, VOfEn ER ENEE UM Bm 03 ' ] I EREEE Iu EE HE ' HGR ED EsBnEmI ON, REE MS 1 " | . ) i ' : )| | \ 000699 : Soup 20199, Neviewdsod quantitatedbydib 8/17/99 Abt Stzelsq : : " iB,gCrTrT ---- : -- [2 : ue -- Pr My We we sr-- HBEr E SBEi BBEe | IHEEE E BEE E IBEBB BBEEE B[oo4s3i | {IBEEE E EE EE E BBEEE EEsRiIyE ZBEEEEER ] BEE EE 13 GHG Hom SRREERERAET ER Er hme BE methane) Blank @ Aaalyte SR NESE Al a CoHd dEoET maeEammBlo wold | iIEEE GEEEmEGEEEIAREmEE 1I 82 S SS i vo on yon | iEEEE E SRimEmiReEs (EE EE ae | fImRmE EBmimsmrawn ! CBiVEEBER SSEpEEmREEERNIIEaYs | EIEEEE EBeEniEamnammm | EIEEE E EEE E ia Ew aESH 1 EEE BBREE eam ome E8e BEBR a mam BB BBmR no-m wTomemem a 5 BEEZ wom uw mm E8i% W 2 f3 RETE)o BBEm o..iE. OE--Y. BE sm ong Hof HE : . ueorl 1 c cm cs ses im t Gouive | bbSlabs :: - | | SEREEGERE ae : Ee | Ha a oc pam Ema 1 EEE ELSES TEE Suigshaors damn ER amoamam OEE ERR |tOBIEEEEE EENaatEheeammmss 0 BEE 558: smn REE WB BRE 3 He ES EEE Es J BR Li 23 ER HOE EEE (Ee 2 8 BE Re eg Bh a gp m W4 CWome Weary), 1GhiaEm EEEaRshe Ra SH RRR | | | | mncommen || HBEEROEogSi IERfMFEER O3H fer ooERE 3 . 000701 : Pplpe --SCpac--tern -- :. p"_d IE BE rB SE Er RRrEgeenemrn. : eee Te maa EE Do SEE imma BowEnEuRe. Fi BE. ws om HO tan HE 3 | | SBGEEEEEERN ESEfEnm EammEE eElE EEE ELT. LQ BBSEHE BBFE OOEEEE OCEER 8OB HHEER o2d OEB H#D3 | HGEEEE EE EDEmRnnOnEmmMEemBsERsEOSNE CMT eEPBEmeo.MEW f8 mums HE 3oo | HHmEmEm EEE ES RSEE EAaR mRaRs Emmis F5d FR nim on wm a GEE EERE ama 5 tDoo pmpmmmemm S SEaS nI aUNmER GE fE=T im ser um eww a jPiEsE SEERDEEEEmAmEIaR gPeo... , jGBEEEEERR EESRRtRmhsEmRuaAmEmaSs | gEER ERRERBES FBBEEE T iHBoE f E HBEEEKE Z3 M o.BE PH: | fEaEmE m EoeEaE n GEER maEw EiBBnE :HOE iE EF HEEBy us 3 i BSEEEF ER SSEERi Au LER M = gE AEO 2 BE EE g EE: g FjEEE EE RmEER | dEEE aE adEmn BBEh oBmEi-BBE HgEE 3 BEE OEE OB HB 3 iEEn SR INRER BE OES BH 000702 ' am | EE. BUTE ] (CCoarlibirantitonocfurDvee:e0r.m1p66t3e6n2 +x09+92043211271 | [Fone Gg Exch ih | 1 1 1 I x -- . Acs eos Ls x : :| ---- : : . | pr ) | %7, = i | . 1 ] 1-%Conc EE | : | x' ' : - . . 1 "0310) 060 0 {| eeemrm----------or : 0 0 1000 Cone ) 000703 E---- ScFIAaTIUtAh, S vEm annE NIo :E n .. eofmfaipcoiuenndtoZfnDaemtee:rmiMn5ation: 0.989930 Carat ure 0135754++347400 Come ype,Linas Orga Exciode, Weighting: x, Axis trans: Nome 15 I . . Response | . i | 362; a | i) x | r%conc] * ii | . . :. 53600 0 0 0 1 steconten cmsdeatnn or i W360 . : 2 x . 0 10600 Conc 000704 | = | SEE "ompound3 name: M6. 1| [CoaeflfiiciebntrationocufrDveet:er0mi.nat3ion7*:x02.+98623.5115716790 [Response type: Extemal St,Are Co | [Curve type:Linear,Origin: Exclude, Weighting: 1/x,Axistrans: None 4164 1 ]. | x : . : | pit . x. 1 I-%Conc : ro x ) ex x | Lt . i . 2 | 0.0 200.0 400.0 .0 I eteccm candernnn 3200 * Cone .0 1000.0 000705 leg | enim, SETS . Compound 4 name: PFOS 1 oefficient ofDetermination: 0.980427 | er type nea,Ong: Enc, Weighting: ix,Axistrans: Noe 1.4 1 - ] i. 1 "oo 1 co | . ] 508 x J J: . g Co : 1 |rscee . . - > | so RS 1 84.1 0.0 200.0 1 .0 600.0 3 * - - 800.0 1000.0 000706 Cone ' I[eRsepeopneonsetFapceorE.x2t4r2.a19$4, Area | 1.653- ] I Respor ] | x ' : . | 33.1 x ]. : : ] So C1 ] 1-%Conc. : x } I . | 209 ots ' 0.0 0.1 02 03 04 05 0.6 0.7 0.8 0.9 1.0 1 smitecoins qmnctatnssn etn vr a 1200 000707 ml, SS } rn vamos pb pe laslas EEE Pntontion Ee jy . 1 Gmmimaoc mu . ] i aE = 1 oTar ws 8 ... | Eee pee Evens mm . . EEE, 8 | mmvngigre mm | BF um ] " ] . | . . | | 000708 : esis, e i m al oer weeds | EEE EE ma ] ire bm J mmm oH e t, jo mE 1 vE et | Ere = Emm RF | Emme pm. | BmwF guam 1 1 : | . i | |. | :} : : . ' - 000709 . { Se ie bid TT " . rr wa34snin om mshmim. aEL Arthe ou2wte a aclaufas ER, HE } Co ] mmm Ramones : me I=Te so | cHosmenin. EF. i mn EJoeRy E ask Sepration } :. - Co | mmm ]: mam } : .. I | . | | 000710 - Erin, sme athod tiie IVASSLIE Tata.FRO\NGEATI\ 32350 ac Compound: 4a ores mp E eal Pa. Een . | EEE. ES ha Te | hEnEE : ] mn nip EEE a 1 BE an Ieime : |lEre nosmnnmne HEE 1 | | | | | L EEESE . 2 ~ 000711 : I fproorni ad rod 0 / | EEREE. pia E I Emm ]an ] EDaEmEe Em BoEape | Bh |oiERnnEERT i fick . | gEEe 1 na OB TM OBB fe : peas : . CL : . ' . | || | ! * . 000712 : (tog -- Massiyn - SampleList - Sa ma uses Se. Sample List: C:MASSLYNX\ats2.PRO\SampleDB\060199. SPL Paget |, }1| mm gFiumomro mse me mFmleeTewsanw Po] mm meme wrie FpMniekovMgSeIssrn otermeiyse |oo{mEmEEeEaE Poms SpmmsmEmieaoenmiesmncmoaepeiee:es: r F sfier ove nee errs en F fneornsiesss sn 3 o Bbh ofog Gmm esmmm ncemmoeemi mssmoisoeits sintogon . ie e e neans se s isss ee eonses me BBBooooog mmme 1BBoBgiem m p smeoa emsiis ess emimmaai, nFjfinlereeomnsessniseeeels sesmenes EMILE eed | E gBBEoomot O mmms ep m] ommemaieeis Lo gJnpmeiionsnnttisasss esssemeeled finrceaesse se |B3PBoomogemummmsn mp Seaomnentoiels enew gpFprnaoenssniesesss emmeenre |I B3i30 i0oo60Emu19Ee9m0en49 m soormaeetsee 1ox120, 13M-g1, 4/18/99 MjnSMeINs-ouPaOAtAnw-i51s3ee-e61y3 Smggsienne-s2 33 3B34 o0oo6us 0gg19ee9m0ee53 3 fms `m mp mmetmhaanaoeo lnbmlianekmiliuvss ees socom OppppMIuuuhNi-ssiPsOoaooAwswAw-stii51iiis3s-sss6s1stss3 omsBmmmeieonhe-2 pneontiss me 4B 3 cmo omsmmm Eboalsee dss ile pp neaonmaises esss hmRee2 BER#4443 :ogu060mmm199sem0B 62 10m smxR 12i0a,m4m 1mMs-g3a,. s 4/1s9/99, 410 gop pwede *SjE ipMiINnni-ePsOaAsaAe e-t5ti1t3s-ee6s1n3 wgfSmihenn-2 pnomisel gh: L ogofggumemeee 5 Sen smi biimummasmva asess mamaeeuew mF Eppnaagoruriaiaiisnels Ee: IpEbie: ofmwmmnm Sp iamtme heidceum ppmumnosaaasyiinesse OmERoe: IE 37 mm06R 0mm199mr076 psam eaa ien 10x120,34M-g3, 4/19/59 Lpo o eer rs SMIN-POAA-513-613 omin2. ER | 000713 | Rasvhleslets Serpent cuss onan Rosen | Printed: Tu Jun01 16:19:18 199 ] |B0 FmomEmmemomen i momemmmmCmesO 8 mm 70 060199089 noE B77512oomia0066E mme00119m9m99sn00m9010 Ba 3 omiomimdmmamem L| POBR mmmoeemmmeeee Drp--EeRanee,s ommommBiae mbpummemeidduepi 10x120, 43M-g3, 4/19/89 10x120,45M-g3, 4/19/09 Ssdemaeimlinpilse|s 1ox120,46M-g3,4/19/99 scm SimeEmmmmmls aees SS imcmmmmessis EedwesEmeme ecpaesld | : r=ez gSSaemicmeeosmniesenesss are aaenndgs raosiamamodedveeseseenesrJssmemaednd ammsser ed SMIN-POAA-513-613 omin-2 . SrOpcnnMMInIcNooN-c-aoPmPOosOMAAsMAAvse--e5i6r11ze33eee--e66sys1y133 min-2 ammanneemin-2 Lo panprmeoieoeessmmmeeooesryneJ iammenned pMnamcnecoooMmwdssezeseessss aEiannn ! 000714 | ae | ER ETH------ | ETEee | Emermh : 1 Fm bi in ] mp hee Ee | ] - ] ] Co | | | i | ~ . ) o . . 000715 . lB elt - Tuning Method Rapes [| matnoas CASS RATS2,PROACGUDBRBO\S J 1 peintess a un 01 16:20:55 1995 - I We :e--------m--m----m--e----eemmm i 1 II = 1 I Ee = TE ze |[! =cSaOpUtRiCtEar(y ESP)rSBeosucreicvaa'etsirioon:ck TTee. Set Rdbk 32 1.00552.97 3Ua.i2 11:22 1 Preamzes naw }| aratyses oun Gas cont i 1u6ems sae | | i : Ms1 [ TiiononRnEeesree-- risus!eioransp oioRnigrser woz SA aaiRteesocelueion oYfoonnn nEneerssy samp pPet Set 1i5.,0 Rdbk 2F3 H% Eo . 1FiA.0 W2&% w F%i 000716 . FACT: DATA REVIEW SUMMARY FORM Due: Glatss Analyst: 1 FACT Study Number __JO X (20) Matix Pre TiaPats = . [Analyte4: ceptableLinear Range: LQforthis dataser: Re yusd fordiferent eng? | et: Tr coeptable LinearRange: /1=211/ /04 | LOQtortisdataset: _/_l/pff i [Rocilusted fo different range? _ } |Analyts2: 222 cccptable LinearReng: 5 = 44/4 | OQforthisdstaset: __ 55.60% | Re-cvaluatedfordifferentrange? 2 ] aly: Z [=F cocptably LinearRage: OQfor tl daset: [Ro-ovalusted Yc differentrange? nalyte 6: cocptabl Linear Ran OQforthisdata sed Re-evaluated for differdpt malts 7. LotQisttunrer _ Sig 0s | [Reoirctbiutisnumngder a | N} i 1 [EN !\ L.0Q for thisdataset: [Re-evaluated ordiffrentrange? 000717 . . : Bs Clin dhe SR errr : - I Ens SE enn mr {Ege Ime Bie "Em gg (EE SE sams gHiEnE S ER AEERsTS [a EHEEE gOBEE iMEE EE J8 gWaEd 3 HEEEEE oEiEmammaem |I GHEEEED sEEEEEmam BEEEER MHEE iE BoH EomEER OG gBaE omLL oa y I jBHd EiEEn S mSEmwaE eEnmmA aaemmL Cop sEERRL_ EEgEoE=nn TH i tE see GmE 1 oE mrean HSSEEEEEE S EEEw ERai EIE BR EE HE PomE EAH EBEE eumSuammen jFEEEEE zEEeSmawomimm fy B2E Be ve dH w E OmOH a BEEEEE SEED SR ELmom GEE SEERA 2] ER. HE mas HE mE SEE SEE EES a oma a L BEE Same Fd BE Homme iE EEE Bw Tom EER | OPREEED SmmEEEmaamm REE mmameee 0 BE Bae me di i E EWEaEEss } SdaEiiiy SS EEEEEERaamE FEogiNE a HOEOEHEEEREEEEE HEE di BEES ae mean BE Fo HHEoEgEaEsE FEE Swinson Ba TL EERE. CRFiEED mame HEE EE ARERR HEEEE GoEpm oJu oEgmEdY HEHE BEE Malia 0624901 quintisted and printed by hey 4/03/v0 000718 mmm toni20, 91-3, rei [HELr I, So r 2eo e av. e | EE sme mm EE EE aRess 1 (EEL EE SEL GEE swammem 1 HBSHEEEEEER BGEEEEEER ESSEeEaamammRE S SsEeEEaR ammA 11 HEgdHEEiEEEEfE E SEEmEeeEEBdR RE 8E. HSFHEEEEEEEEL Eo EEEEEmE eneR een | SGeEmmEm GSnmEaEh nUmSn |DoGp BEEEER mERe aSnEmaon | E SEmE GBEEEERR BSEeEad R0 S EEwEaR 1 1 EHEBEEEEEEEE EsEsEmEaaEEmwmeReoEe E | BHBSoEmiEaEt EEE NEECSEER Awmaaves mm GgiEnEg m SEaEmmaim | REE Esme |-ORFrEaEEmEEs mSSenBaamEmEe | EEE mE EERES [| m tsen tvr a = ) gh BgBonEE,MenoTwm sng me iE BE OE IE HBoEmEE OBER aes a seFEE EEB8R 5de enw mane a B B=E EL ESiE ' Ll. EEEi oe iw em E EE e HHEFF HmEEEs FESoRE] ii iE gWBEaaEaaEss F[oE B=E] HH i EOEmE EeE. eE E[BE o=E] a HH 1 oE gm EOeBE eEenEeE EBfBEEea. HHE O~ fOHEmEEEsE Hgis i Bay ge EE BHHEEEoBaE ELfyeamee ooan mm ORE OF BEE 4 000719 SER rs EETrLa, S SoE n-- n R, ws {Hh fmm Pmj mm ESE A ma E || iaEE Biman ESSmEhaAEmdSseEeaEEREEnL | ficE HFEEEE S S EogaE e anA | HHEEEED SEweanen I OBER |pEE She mee BRS DOsRRimmEns cBBhEEE SB.mR wOeRR | SEED HduEmmER BE BEEa RERmn oun HHRHIEEEEE SEEmEEaREm eoam | 3 sen ie:lei cent | PEE EEE SmEnam mEmRamE GHSHEHEMEEE SESEmEeEe IEEE fi swam PgReEEnEEe GmSieEmIEn:ha0 lmE Co HEHoEEaEEn OHIEEE SEEaEEiASn, EE SEAT HEE Sw amEeE AoeLinSCAU avanti wdprintedvy sesarez/ee Bi M0 am omnnn m BEmooWmRgN NaNeR aw mEREAGMEE ETOME HMmEF mmmesw OE EEE ow EEao] FEEErre mem ow mean a 8 - Gg TU Ei woes `EHEEEFL. HH HOF pF BgmEaEEe 8 EBFE ae BR HE 48 EmuEun.se EaaE2 [HmEEAoog EamEy faire 5 es sa nme 3 amin -: gBFir ETL UT Amameen E 5] e aw nome a gFeo Samoies BE THR : [Ea woman } ow mE OOEBEE HE 4 geme 3 iE ogE Ef BEE G . 000720 S -- E EEifHun,n ErEeEnen ----n-- } ne : ----er maze Be Me me onmee EjEE |OBHEEEE E ESEEsaAmmmE eeR waned EE BE E ooE m ad 8 om ooHogEfy g3odf | jiiEEEE FEE aEEnEmesmEaianam Emma 2 Fi EEd HfiooEmmms mewoa I iiBHEEEEEEEED EE SEEweEaenRnARo 0 oEnm9 B5iRE ifHomomsEH omEmredaow HOBog mHEed Si SHEEEE E ma EEmEmaREmnE i EE5En fmHooEmmR HBEoBB ooHmmEe ooaw3 HmEod3 SPGHEEEEEED m mEElm S mnm mRih GBEEEE E SmaEhnAoam i E BnE 5.iP owFoEF E oEmmDeodooad SEE BGEEEE m mEE m m Em RR Eiu a EE Hog# Hmeid2 HoEET mod IEHEEE E mcmEmtE. | Emm mEaR 8 B Br LOLe BOwB omHepE 4a ` oSdm EEE sESRpaEamammmE PEE Demmi EEpBiEErae HH1HpoOEC#Ew HmaHEweEEwow3oowd Boo. Hod GiEEER S EmEaEmR FEE EE Sha FEoF] Ei OE E HaEE oodd SEE BEES SE ame SE mmm EE dom Mom ome BIE 3 EE om om MEd SEE EE EREEE EEE HOHE od nella SII quantistad and printed by hes E/08/08 000724 th Cla | SHB qh : = | SINTER, Sn eens ' 1 CF octhctenofDecrE momon: 984688 i iCalibrationcurve:0.331359 anes CFio 0 iCimer37p2eFa Chen, Weighting: 1/x, Axis trans: None ee. Ii| . : . ]| | 3 . . Co ' > Cl x | . . Ca H)||| : . | :{lee ; : ii . | . : 8914 = 0.0 01 200.0 sidss ts yn .0 ~: | i | !! .0 800.0 1000.0 Cone | "4 000722 SE -- ITIL rime ) | [[CaliCbrateion ocuDfrevet:e0r0m5i0n7i4o2n8:*0.x9+8-5405.5140609 | |Frm Ca ie, `Weighting: 1/x, Axis trans: None . 101 | ]| | x _ }- || | o| i | J : i x * : i | 0.141. . i Hl 1 | ` | | RY : | | i! 2 ;i | : iS:9% tataskp2e000sny rn 4000 gbo EX) 000T7o2og3 oo SEE J BIL, Smree Re [Response Factor: ok WYArt . ii!i Lue . : : |i } - : 1 ao ` || v | . {| 19.7- 5 | | | Iho, . |to' # |. Po ) fo ; i ) Fii Das ; Cone 0.0 0.1 02 03 Aonida0638 quasnndptrintiedbay dtes a4/03d/00 04 0s 0.6 0.7 [X] 0.9 10 - 000724 R| E | 1 ] 1 I | | | i | | | , 1 SOUP 020199: FACT Equipment Log 99014 QuattroII, #6414E ANALYSTd:h PAGE Hoel SFTAUCDTYMeNtUhModB:EREITTSO-X8::15,200 MATRIXRatLiverDESCRIPTION;POAA analog check Injectionvolume:10ul, Cycletime:9uin,Electrode: Z:Spray MobilePhase: (AY2.0 mMNHACH3CO? MOH TNA-orsmddmnber (A) 9012109. GMINA) Propued(ucly): (N0S0AROdD| (Blosomedn Expires: wae maew Sorcatroom eng? [ or N Ober. m GoaerdNn oepeo' lomLm:ewatem Analytical column:KestoneBoasl Sze2sfomm TyeClS Spheessesun Part umber: 055.7012 Lomber IL08 Sei mabe Analyticalparameters: Drying gas (Lhe): 350 ESInebulizinggas (Lr)15 Sheathgas(Ub) 0 LCFlowrae:l30i0 n, Backpress55ubarre ~ . BPLCsolvent gadimninta Tmemin) sn 210 Das RI N00 400 eso #80 -- | Co 000725 . Re oe/o3(1] : --- Massiynx.-SampleList : Dee Paget `SampleUist:C:MASSLYNX\soup-rat.pro\SampleDB\080858e.SPL o9/- -_ w- Fl Nama FloText MSFle InetFie Botte [131iooosx%oe0av0so0eam 0nceta m TToMocox1o21e H020,B,RnRBkBLOLAOIiSSRI1O0S0e01-10,014,p41g916K8 PPSOOMAARNSStT:: POAST: ooEmmiiRnng2 oming 81 23 75& ooooxeaeosoonnn0ccoser 3 oeenoon TToaOiHR2:01B2,0iRn1Bk0LGO2AGB-pA1b0,04. 0 VaOHBank + PPPOOOARRKAASESIYH: PORAST GoGmmiiinnnggg Sming 40&1 G2 1 ee TOk120,38MG3 OMAGH oming Volume SampleT ConeA 11i00 AmAvaaegao 10 111000 ASSvtaaannnddtaerrad o10o0o 111000 AAAnnnsahsiaea 1i I: 1 : | . ii 2 . ~ N. 000726 y , [T0X120, 19M G2 (08-Jun-1999 15:00:50 0610899007 % i 271.035.0409 1s0us6168232265274_ 356 , |osossso07 I |% J Iss: 061 0899007 | Ie | |060899007 Is i 3 | J1osossncer : | : . >LSBelo fi a i Soup 020159 3M Envi7r:oMnRmeMnotfal1 LCahabnn-eFlA(ES. 598 Tc] 114e3 610 su 57 72 146164790 35s 3:MRM of 1ChannEeSl- 385 1.0T06I3C] 744 EN 6: MRM of 1 Channel ETSIC-) L164 sss : sa 536 | 2: MRM of 1 Channel ETSic-) 9313 5: MRMofz 1 Channel ETSIC-) 1.54eS| ] | 06x0899007 sa| 1: MRMof 1 Channe1l5ET5SIC-8] | 060899007 I= od 55 \ AS 0003703206 100 200 300 us w 426 TWH 400 500 597 6206 600 4:MRMof 1 ChannelES- =494] w| 136745 asad 88 700 800 Time! 000727 mttns ,Eot mEtsTn 0 _ ~ xel Shol08(% RESET ]| Em Fi me sen y rm me i ct ro 2 43 i | i ag hae dmSowa ' 000728 | mwo e t meovasmossmmomvcsESoRooS | re momo meen =2 st ou[02(99 | REE | is 1fi 1 isi .X BEST COPY AVAILABLE |`8| RR alien I NN oStoeer B:ym o18 1 Emam Source Block Temp. Bom 150 153 | re i | tyne von --2.200 | 7 2iEreSseotmucetlen on Lens 6 i. I pSimtis jET orl] .e wna 1u3i", 50 2 Sli gw5oo o ow | 000729 . AMELIA062498: FACT EquipmeLnotg 99016 QuattroII, #6443E. els . mee ~- PAGE,es DATE: oso ANALYSTe:e STUDYNUMBER _Tox120,_ FACT Method:c0 MATRIX:mtliver DESCRIPTION[;2 | me ee ---- i Injectionvolume,10 ul, Cycletime:13.5min. `Electrode:Z-Spray MablePhase: (MpomMNmcmOR ()Meom ] TN o snA d a: mber (A) 99012106 @ meas Propued (Gay: (A)321591as 9 w | Stat oroomrteemp? [] or N Otter: | `Guardcolumn: None [-- Lotmmberz,a Analcolyumat:eipsocn barls. Siei2x100mm Type:ets Sphere sz;Sum ; Pattmumber,__ 1057052 Lotmum" ber,_g7hi2 Sera umber0636405 ' | Anataparameters: ! Drgyas(iUin);3g00 ESTacbolgaisz(Uikn)1gS _ Shegasa(Utn)h0 ] LCFlowrate: 300umn, Backpros80eb:ar . ] HPLCsolventgradient: pfbs1 } Time 5%Gain) 3w@ | : 21) s10 5 | $5) 10 20 | 6) 120 DBs 3 ow ! | 000730 Auslin Onl SAH bh [27 Massiymx SampleList - . P`riSnatmepdl:WLeisdt CuAnMA08SS1L6Y0N1X1a8m1e0l8i8eats PROISampleD810636004.5PL /9/93 mEs Page . FlloName FileText | 321 C00B0%O90S9BSG0RO00O12S mmeettohhxaainnzoo0ll.bbmaaann2kk230-HaOM1 | HI 6 0G09M9B0000085 oz1r1h0i2z2a2si0aS1oroppoot ] R omene pXmie) zmime! 21MO0 00O0N0000GR0RO00II2 ktowoxciiizzzhd oOOssssasssT0oe0oe0nn]]] 5113 00088B000000G0066G00011TS43 tocmiiaahD,an,ct0bi6iaaFsnOsks11-002050p0ELptp2b2m2e5,0 1I6T 3 000B090B00118T meee iboxii2mz0d,. C 0U6GrH-2i 0510.ma 2o5e0Hpmo ip4eso2,s2m9s 1 221 O0000O0960R600T02210 mltooacxita220r0.,)1mb5ia92r-2k0540,:20280 E222R3 00G000000000022 tttomoxxizizzD,0.. 110S52462F.2-4O8,sS8oo0aap%p0b2 | : I22 0O000B00I0%T 23 000009020 ttw oxioz0.i c111595760iFFd OG-e2Ok,,220, 22e22.as0s toxizd:M02202e0ppcd i 3RM0 0O 080000N60030 mlloootcchilazanDhoSlSTbalMbaGonkHs,.19m%e | 33 000000U8G0308 ttoixizzh0..msioIhosoz,Gs4e10apmpcch 33T8T5 00 08600800009900335 f`tomoceettihazaDdn..oGclIbolNaonGknA4119a0S0 ] 433 00006000G0G0GORN000I33008 tomxlai2a0or,6HxbIOaMSnCiHk,z41p0p9e0c.cS 4421 0o00o00u00o0o00044d21s llooxeuitia2o0s,..11176T00F-FG0-o55,,320a23n28s80 1 44465 00O0000E9600M0004s85. mimaizote.omw1b1o3atno8k2s5,d0s2o2p,2n0cel 47 000047 |ioxi20. (T4F-O8,Soave 44289 0000600000000086000454800 mteottxhizaoDn.olx1b7a62n-i20k8,zs3eaaddmge.e? S52S 00000B00O00M0O00S85T32 lotxooxixiiazzDDh.77469M0Mdd.-.2aa5sn00G,,.G44155116,89,,000 5B55 O0000N0000008G600855 mleootxchiiazzDn0..otmlNbo2an2nkSBsHsIoOpMpKeZc) | 8ST 00CB000G0000GM5078 ikoocixiiz2z0.d.mmuouzsssaszssRsLSTooVnppshSe | 0 omos0s wiz.massazens r MSFile InletFlle Bote BPPEEHHESSS pppeaattt ai0 ms PEHS pat i32 m PESempal PES pal 878 BBBEEEEEESSS pppaasttt 8i1) BBBEEREHSSS pppeoettt 223 BmEEeS pr pmset1 iis a BBPREEIESSS pppoaeettt 327% FmFEHeESS popomaeett 82i PPBEREESSS pppheeattt 22%1 FBFEEEEENSSS pppaaettt 282 PPPRHSSS pppaeettt 228 PFBFEEHESSS pippooasettt 224 PEPEHHHSSS ppphoaasttt PHS pat oz8r 2 PPi rHiSs ppoaett a230 EEPHHESSS pppoaeettt 3%21 FFFiESsS pppaeeltt 5a8 PEPEHsSS pppoaeettt 3F5y PPPrrHaiSss pppeaetlt 55@ BRFruEisSs pppaaattt 43@9 PHS pat a 000731 . Mola MbE cht utr? Te i SA. Be SS Xamala-rats,PROVSampleDB\I049%a SPL ] Flalame FlaText || F| 2E5 a BREE nw 8 Qoooaost toxia0.mozeSopot B2Ea ii sre \ietFla Botte va BFHS poet 4 13 1 . J; | 1 Co 11 o . |N . | ] . I 1 000732 : [242 Asli ua SAH Lll99 Tuning Method Report Sage 1 Method: : \MASSLYNX\AM.EPRLOI\AACQ-UDRBA\PTFOSS P-- rinte-- d: --We-- d Jun-- 09 15r-- :01r:35-- 1999---------------- .i. i s soca ( zsr- ) cECaxoptnirelacltaorry |i SBDoFeusrLoceienvsaBtlioocnk TTeemmp.. Pressuces ! Analyser Vacuum Gascon Set mak F 31.007-52.98 2013.5026 21550 Ra 1utent t503 BES"T COPY AVAILABLE 1TiorRReBessoooolltuuyttiioonn MZTeionlnstiEpn8leiregry Ramp sz CiLTooMlnlRRieeEsssniooeollrnuugttyiioonn Zon Eherdy rasp LWeintsip9iter : set mak 211558.:06 o s0EN e Bet mane 1231o50%.o00 a E0 N 4" 000733 . Anlio. (4 . M90 Shi GJuj29 - "/9/99 EE + Eun, STUB SouningMethodRoper. . ST -- Em -------- amare EBT ltrT r str SBth trey em 11 rin 3 sm ie 13 |C ERlIE eEri E sete hBs tsoctmary once 17 i . |i : ! . . f nr 000734 + AU1I UALAKEVLEW SUMMARY FORM Date: Glelts Analyst: FACT Study Number Matix 2d _72(22 R7S `Tizme Points _ : . [Analyt4e: AcceptableLinear & L0Q forthisdataset: Ik lusted for difanfger? ent i bl: J cooptable LinearRange: __5_77 ~ 595.44 | ootxtissnne _S7ops [Reon a ` eT- 2 ceptable Lives Ranger 27/. /957 004 . OQforthisdataset: 229/44 [Reena dfermtrig? _nt ! coeptablo Lis | [LO forthisdata sed > | [Re-cvaftorudaiftfeerednt rie [Rais on Linear Rang: ron [Roriuast de diftrtrungs? EE 2%) coeptableLinesr (LOQ forthisdata set: e-evalfourdaiftfeerndt eng = coeptableLinear Range [LOQ for thisdataset: Re-cvaluated fordifferentrange? Recmpinmafion of 44 G5 data. Mejor i differences bbom + PERS levels in Por : Jers sf wales temales 1s confrmsd. ! Orignal Vales avs ok. bn w1o]59 ! 000735 [Shy Clots DA | sm mm | BEEL,DSERr ro----m--e-- . zoom : I EEEmE EmEeS, 2 et a ] GEE BESSS 1 SEFEEEEEE EE Em EEa EE FEE EEE | EjEEE SEgmEusRmPRamh E HEE Gi SE SEE 1 |- | | | Melia ORM: quantinted sadprinted uy hej 410/38 8 aa BEI BBBEeE i77wHmOERomoausae - Hop mem HEED BBEEXx nam we. inm ow : : ER rom monn Tu ERE EEE 000736 ) : | mmem-- - -- ] EEuRan,, S r EE e ov--ens |! -- "tee = {Ep SSN Ewmn Mee mae ome (EjEiEEs ESEwE EEEREEA E F BFEd gp B ET F BR om SEE Sums | EhoE =Eamms EEE OEE mm 8 ERE HEEEEE OBBEERR OoEb BoEmEER 4 1 diEE EBEE SfE ama EE i a HHOOHE BBeEs R, | BsHiEEuHEmE ESEEmmvEaEaEm, HGiEmE S EEN E ve ToBmR Bg TTes: cor womeels E mBaE | | SFHfEEEiEEEEiE oEE EEwEERm ER EERmE E y EE ERE EEBBuu2gegR.mw HryHHmmOOoHEnsne oBoageEnuswEns n | BEE SEERA Ene mr ren BRL. HEF EE || BBEEEER HHEEEE S EBEEEEAm EMGSRaa aEaeE BBBR EEEm oe E Mi. EO3oHg T EoAEdaEe | EE EiEmaE, HEE SEESae vm ER. EE EEE iE EWE. 1 Hime EE Si ERLEEIEE Eien PEE EE REEER Er me da Boa HB OBER : BE OE cu per 1 SPjBEiiEEmmE EoEEEmErARRssaEEmeaEEem EEEEEEEEEEEE OBmmMEEEEoR Em gCoOOhFE aoomfgapuEmEE ooAy [me tm 000737 . ) Clter "2A ny i ee - - STEAL, Gm Y omo. C -- op-- y ------------ Boattioonnc cuo e e14f 0r4=sf+0.xi 99+6c 20831i ,5r*1e 2=n 0.9t 921: 78 peLies, OnEco,Weighing: Null,As res:Nose 3. . . 1 Soe oo PM . . -%Conc * x * J"--0----2--50 X) 5 5 T5005 ome] : 000738