Document p6XdXeGndNY1kpmrnL6bXLLE

/1R126-OK8 ATTACHMENT TO LETTER TO C. AUER DATED MAY 4,2000: PUBLISHED STUDIES ON PERFLUOROOCTANESULFONATES Environmental Studies Key, B.L.; Howell, R.D.; Criddle, C.S. "Fluorinated Organics in the Biosphere," Environ. Sci. Technol, 1997, 31: 2445-2454 Key, B.L.; Howell, R.D.; Criddle, C.S. "Defluorination of Organofluorine Sulfur Compounds by Pseudomonas Sp. Strain D2," Environ. Sci. Technol, 1998, 32:2283-2287 Toxicology Studies Belisle J, Hagan DF (1978). Anal Biochem. 87, 545 (Note Error: In this report the blank was erroneously reported as 0.02 mg; it should be 0.02pg.) Belisle, J (1981). Science 212, pp. 1509-1510. Guy, WS (1972). Ph.D. Thesis, University of Rochester, Rochester, NY. Guy, WS, Taves, DR, Brey, Jr., WS (1976). Organic fluorocompounds in human plasma: prevalence and characterization. (In) Biochemistry Involving Carbon-Fluorine Bond, pages 117134. Haughom, B. and Spydevold, O. 1992. The mechanism underlying the hypolipemic effect of perfluorooctanoic acid (PFOA), perfluorooctane sulphonic acid (PFOSA) and clofibric acid. Biochim. Biophys. Acta. 1128,65-72. Ikeda, T., Fukuda, K , Mori, I., Enomoto, M., Komai, T. and Suga, T. 1987. Induction of cytochrome P-450 and peroxisome proliferation in rat liver by perfluorinated octanesulfonic acid. In: Peroxisomes in Biology andMedicine, H.D. Fahimi and H. Sies, Eds. Springer Verlag, New York, 304-308. Johnson, J.D., Gibson, S.J. and Ober, R.E. 1984. Cholestramine-enhanced fecal elimination of carbon-14 in rats after administration of ammonium [14C]perfluorooctanoate or potassium [14C]perfluorooctanesulfonate. Fund. Appl. Toxicol. 4, 972-976. Nabbefeld D., ButenhofFJ., Bass N. and Seacat A. 1998. Displacement of a fluorescently labeled fatty acid analogue from fatty acid carrier proteins by wyeth-14,643, ammonium perfluorooctanoate, potassium perfluorooctane sulfonate and other known peroxisome proliferators. (SOT Abstract. Accepted, Toxicologist 1998). Olsen, GW, Burris, JM, Mandel, JH and Zobel, LR (1999). Serum perfluorooctane sulfonate and hepatic and lipid clinical chemistry tests in fluorochemical production employees. JOEM 41:799-805. 004633 Pothapragada V, (1975). Determination of total fluorine in serum and other biological materials by oxygen bomb and reverse extraction techniques. Analytical Biochem 68:512-521. Pothapragada V, Singer R, Armostrong WD (1971). Determination of ionic (plus ionizable) fluoride in biological fluids. Procedure based on adsorbption of fluoride ion on calcium phosphate. Anal Biochem 42:350-359. Singer L and Armstrong WD (1959). Determination of fluoride in blood serum. Analytical Chem 31:105-109.. Singer L and Ophaug RH (1979). Concentrations of ionic, total, and bound fluoride in plasma. Clin Chem 25:523-525. Sohlenius, A-K., Eriksson, A.M., Hogstrom, C., Kimland, M. and DePierre, J.W. 1993. Perfluorooctane sulfonic acid is a potent inducer of peroxisomal fatty acid B-oxidation and other activities known to be affected by peroxisome proliferators in mouse liver. Pharmacol. Toxicol. 72, 90-93. Taves D (1968a). Evidence that there are two forms of fluoride in human serum. Nature 217;1050-1051. Taves D (1968b). Electrophoretic mobility of serum fluoride. Nature 220:582-583. Taves D, Guy W, Brey W (1976) . Organic fluorocarbons in human plasma: Prevalence and characterization. In: Filler R, eds. Biochemistry Involving Carbon-Fluorine Bonds. Washington, DC: American Chemical Society, pages 117-134. Ubel FA, Sorenson SD, Roach DE (1980). Health status of plant workers exposed to fluorochemicals, a preliminary report. Am Ind Hyg Assoc J. 41;584-589. Yamamoto G, Yoshitake K, Sato T, Kimura T and Ando T (1989). Distribution and forms of fluorine in whole blood of human male. Analytical Biochem 182:371-376. 004634