Document p4pyvNoXeVzr7gyrDXYx2eX7

FILF I 4-" Desti j "j i u ; _ | , wh M n J1 is ^ RHK | R A !v1 1. : jEPW </\ * May 17, 1963 Dr. William a. Heeks Sprague Alsotris Company North Adam*, Massachusetts Dear Doctor Heeksi Mr. Paul Benlgnua haa aakad ms to reply to your lattar of May 15 requesting toxlolty information on our/Aroolora 1242 and 1254. L------------- Z hava enclosed two ooplaa of an artiola publiahad aavaral yaara ago whloh describes animal toxlolty investigations with thaaa two compounds, You will nota that tha authora suggest a threshold limit valua (TLV, formerly rafarrad to aa maximum allowabla oonoantratlon) of 2 mllllgrama par oublo matar and 1 milligram par oubio matar raapaotivaly for thaaa produota. Tha govammantal oonmittaa whloh aatabliahaa threshold limit valuaa haa not aooaptad thaaa figurea but instead haa maintained that tha appropriate valuaa should ba 1 milligram par cubic matar for Aroelor 1242 and 0.5 milligram par oubio matar for Aroolor 1254. In our planta whara wa manufacture Aroolora, wa do perlodlo physical examinations on our worleers at 12 to 24 month Intervals. Thaaa are quits comprehensive but do not include any special laboratory procedurea auoh aa liver function teata. Wa do not consider that wa hava any algnlfleant working exposure. However, wa hava never heard any reports from our customers of auoh routine testing proce dures. If I can be of any further assistance, please do not hesitate to let me know. Vary truly yours. R. Barnet Kelly, N. D. Medloal Dlraotor REXtsf Bnclosurea CCl Mr. P, 0. Benlgnua - Attached are four copies of the reprint which you said you had not seen. MONS 090357