Document p2a1pyDE8d6njRQyYvm5YnE5j

AR226-2786 _FOR DU PONT USE ONLY Copie to E. 1. du Pont de Nemours and Co., Inc. Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, P. o. Box 50, Newark, Delaware 19711 Study Initiated/Comoleted 11/29/2-12/22/82 .Material Submitted-bv "Central Research &" Development Department Haskell Laboratory C-8 LIVER WEIGHTS IN RATS AND MICE! ORAL ADMINISTRATION TO MALES AND FEMALES <C8) " -- or.11, r. 3 ana 3 females per group per species) a t ^ o s e *? y o ' t i,s,C? ~ i Bice <5 "ala mg/kg of body weight. The animals received a total of if^ ? TX^ ^ ^ X T "observed^^Xt^was^een : x tT md.bydea"h ofAil remaining animals were sarrifG.i .,. , i*0, r 10 dose and the livers were removed and weighed! " ' tha laat mice 1" both male a. fern,!, liver weights were noted in ,,,1. rftsf aiiS'hirt'i3' changes in female'liv.r S g h L " fdo^ LDte'-l mice (5 males and r, Crl*CD rats and 3 groups of 10 aeintihmearU 0.t 1<, 1.i0 or 1.0cmgf/k6g of boud*rwweeiig&hc?P ^An aaddddiitMio^n*a!l croup loefVCl20S f i " i " . d ,, " ; e " " bj r r l l, trida, for each of a contentiva t e t s ^ "" af " edoe8d*>' " d "S ',T " day ba<>ra daIa* a" " ^ e d1,` . 7 ' Signa nt toaicit,! af ter'til.'" final ldn.lW<ichen<l`leX'1"ded) far sacrificad and the Uv e r s were removed end gtad?' **" * 1Company Sanitized. Does not contain TSCA CBI 1,- i-: ; Rat F 10 9 Rat M 1 9 Rat F 1 9 Rat M 0.1 9 Rat F 0.1 u 0/5 Rat R o s 9 Sporadi Rat Rouse Rouse F R F 0 10 10 9 9 9 0/5 0/5 0/5 2/5 None None Sporadic weight loss Sporadic weight loss Rouse M 1 9 weakness . # Rouse Rouse F R 1y 0.1 9 Sporadic weight loss Sporadic weight loss ` Rouse Rouse Rouse F R F 0.1 9 09 09 Sporadic weight loss .:fiifftpp|l|f Sporadic weight loss None ; ' ' ^J-:. None ?~''":: ? Synonyms : p Ammonii Prfluorooctanoate ** Livers were removed and weighed bv C I v ^ Supervisor Acuti. i,,,, 8 Dy f a ` L * Kennedy, u I Section toxicologist? `-tliation. and T. P. Pasted; Research tePOrt b" ; _____ i U v % /.,'aJ.a Calvin N. W y # e Technician Approved by: iaNU:jta:ivP:2.d!9 U ate issu p rf t.i-... i a. basiteli Lab. Keport f.o. Jjs-H .Number oi pages in this r e p o r t : 4 Gerald L. Kennedy*, jf7 Section Supervisor Acute Investigations 3- not contain T S C A C E Company S a n iti^ - Ones Company Sanitized. Does not contain TSCA CBi 4 I t