Document p2QMJ3KJ7eORpd6Z7LX1EpmZ6

w* \iwi F ft* MANUFACTURING CHEMISTS ASSOCIATION 1825 CONNECTICUT AVENUE, N.W, WASHINGTON, D. C. 20009 (202) 483-6126 ly 4 K January 29, 1974 ONFI_DENTXAIi To: TECHNICAL TASK GROUP ON VINYL CHLORIDE RESEARCH Subject: Proposals for Additional Vinyl Chloride Monomer Research_________________ ________ Gentlemen: The Research Coordinators, at their meeting of Novem ber 28, moved to ask the Technical Task Group on Vinyl Chloride Research to recommend to the Management Contacts that the spon soring companies authorize the expenditure of an additional $80,000 for metabolism and teratology studies (to be conducted by Dow, at cost) and to alert them to the probable ultimate need for support of a continuing prospective epidemiology study at about $100,000 per year, and of three-generation reproduction studies and mutagenicity studies at a still-tobe-determined cost. The proposed budget for the studies for which immediate support is solicited is 1. Metabolic Studies $50,000 (one year, best efforts study) 2. Teratology Study 20,000 3. Contingency Funds 10.000 TOTAL $80,000 Enclosed herewith are the following documents, all of which are to be treated as sensitive and confidential, and restricted to those directly responsible for making the deci sions on the subject proposals: 1. Report of the results of Dow's studies on the effect of exposure of rats to vinyl chloride on hepatic sulfhydryl levels, 2. A protocol for metabolism studi s on vinyl chloride and ASI 00007073 CONFIDENTIAL T chnical Task Group on vinyl Chloride Research January 29, 1974 Page Two 3. A protocol for a teratology study on vinyl chloride. A letter ballot on the Research Coordinator's request is enclosed. Please return promptly so that this item may be placed in the hands of the Management Contacts for an early decision on whether or not the sponsors will support one or both of the presently proposed programs. Sincerely, KDJ:mb Enclosures ca D. P. Duffield, M.D. Mr. D. M. Elliott Dr. Tiziano Garlanda Kenneth D. Johnson, Ph.D. Secretary, Technical Task Group on Vinyl Chloride Research ASI 00007074