Document omVdQadbJawa1dg6q5NEoQoLR

FILE NAME: US Gypsum (USG) DATE: May 5, 1937 DOC#: USG026 DOCUMENT DESCRIPTION: 1937 First progress report on asbestosis experiments. CO PY iirst Progress Report on Asbestosis Experiments at the Saransc Laboratory. May 5, 1937. to group c ln the 1,jnss of film conparable'to those seen in'hraan beiiL sinota?'S r'-a?n?"r7 be killed as seems advisable it oH.li be oeca'-'vn nce ^ae animal* can cP=n~-e"c min ttnheeiix- lluunng^ss *whitt-hb t+hvel shadowbse ?sesesnslDinlethteo fciolmmpsa.re the anatomic xO make certain whether the fibrosis in tbe- In^cr ic composition of asbestosis or whethei It is thb - tion in the rails of the air spac=f r e u l M ^ fiTM ^ 01 +-> u > Y ?,0?6"10-1 nild irnta- ihjectio^experinents in other organs it may probably be I s s u n e ^ t L r c ^ i e l n t i " !"1' " 05 o. one tissues is not responsible for the pulmonary f i b r o s i s . " tsof,,;Urt-her =h"ck on the Physical vs. the chemical hypothesis the a.?1 "F,^?C1 serPentine is being comDared with that of ch^y^otile ce irnsiurSucttxv-ei win!atTMevetrhethseamerescuhletm.ical composition the con*caii^n s=-W.~uM^u ;he aFti?n of ^ricus members of the asbestos ^ 0uo ;ri;nIyloU?e*a 6 anthophyllite are all being co?ared Ath. t S t ` been1SJ = ^ f lyF^ report more than the fact that the experiments have -*r. n s n e r f**romfoar nit=hnet inhaula,t.i,,onnioof chrTysotil.e,? a du0t-*nu-~nni?-cvhedl by vo^e-i-p^ tv,^ xianville, N.J. is c e m a employed. As a * - LI" -:Ctlvec 7 -ne G^st was not sufficiently fine fo- tf t^pe ana ~e were forced to remind i- in a' '"b 1T?nts,- ni 3H,fv; in experimenting with a proper"tyne~of miiSfere 5rch !i. *"** Ci:;iculty was a c o r n and inhaktion ' In the dusting room we placed SC ruine nia-o on a ,, -PS. :iore of the latter rill h e V o e l r l d ?he;`& o L " S b S ? 3 ri-O ct~ i , ^ tJ ^ cen,trrti?n of approximately 175 million oarticl== nS ,novr beinS maintained. This may l&ter b= naan sea. ^ ^ us" T C: T Ci / ^ *-h*: particle-- w w C* nw is. x n! ! 5J mior >, - * - f .er. iince significant resulti cannot be evne-tV`;'' " :h'Jop " til exposures have been continued for f o i V * ; ? raorc ^here can little to report before t*e Pxoir=tion ot'1 th* -- eiIaS U' W ion **Sert" * * e fSriSS;ridiScd have"been a ^ T h e ? eH~<c'a U " - n ^ l Pr. * * * * ' U dsts **? " ? * * br aliutriatn. 'onp r.ir'ticlls 1 o ,, ...x.c^Oxx* uu xicae usr were used. T'neir -uiin t.,o ~ 7 necked by the same methods of analysis" T h ^ v ~ ^ u ? aoulated for your information. v,._ou_. tes .s are Chrysotile (Thetford) a. Intravenous Injections. Have proved difficult. 7 rabbits hav* d i * * apparently from mechanical effects, without* receiving significant quantities of the*dust. .u r ^ e r attempts are in orosress. |5^ri||7itoneal rnjshtions - 5 guinea pigs, aarch One killed after one month. \ _ U . ihibole No gross fibrosis. a. Intravenous Injection. L rabbits still in w o - s 5 ; received 11 coses totalling C.55 gra~c * No iatalitie.s'. 7, -- ' b. 1937aperitneal Injectin. 5 guinea pigs. ?eb. 5 2 killed after 12 and 30 days resoectively Dust plaques without gross fibrosis. J' ^ esite 81* Intravenous Injection. L rabbits still i- ~_ NoVfatalities?1Ved " dS6S totallins'o.55 rais?SS b- Intraperitoneal Injection. 5 guinea pigs on Feb. 5. 2 died of infection. 1 killed after 1 month. no fibrosis. Most o** t^e duct- - ~ zae aus- absorce -3 - Crocldoilte a. Intravenous Injection. 4- rabbits .h*ve ea~- ` dSe f ne gram ln '20 W B c z i c n s . .-Intraperitoneal -injection. 7 guinea 'pigs L: 2 died of infection. ' .1 -r~;- -- .... . 1 killed after 1 month. Pigmented "dust ' ~t j ; plaques without fibrosis. * " .. Anthophyllite .. a *- ^?*aYenolls Injection, h, rabbits have each received full dose oi 1 gram in 20 injections. 2 killed after 3 1/2 to 6 months respectively. No evidence oi fibrosis in the lunss* spleen" liver or bone marrow. ' ' * b. Intraperitoneal Injection. 5 guinea pigs. - .^.^II^ after 1, L and 8 months respectively. - Disappearingreaction with gross evidence o^ fibrosis. ' Serpentine "* Intravenous Injection. L rabbits have each recel-'e^ lull dose of 1 gram in 20 injections. All >ve~a-nd well. " -- c.na b. Intraperitoneal Injection. 5 guinea piss. 2 killed after 1 and L months respectively . Soft pigmented dust plaques without fibrosi*. Fibrous C-vpsum - Satin Spar a. Intravenous Injection, i rabbits have each r e c - ' w ktalities"'3ec-lons?..or * totEl ?f. 0.55 freas... 50 ^* In dp*erit on^"l j-Ii^.1njiep(c**-fw--*uiis - not mac-e. Soda Tremoli-'-p ...... . . . * `" t e S : Injection. A rabbits have each re~i~ed 1 ?rs3:ln.20 taicti0ns. A U liie d b. Intrap-eritoneal Infection os guinea pi.gs. . plaques w ithout f i erosis Joae oi tnese early results is regarded as significant and no con elusions rill be d r a m until the observations have been continued A?iua? one year. It is not yet clear whether the difficult! with intravenous injections of chrysotile are merely a natter of technique or whether this substance is essentially toxic. / Ae aQ rT eQ attempting ^ 4* 4* r . m 4 ' m . __ to -i_ _ dJ i s_ c_ ov___er` ti h* e cause. *