Document omNQkBmkZMLEeeozZ7zO5OaB3

CA Select) Chemical Hatardt. Health. S Softly Issue 4. 1967 R&S 002865 These std*. wan adequate to fulfill thair function in prrventinf eicaaaivc intake. 106: 55130e llflwan of methene coexisteaee on propagation of eoal dual exploeion. Tominafa, Toshio; Uchida, Satauki; Kiyono, Fumio; Komai, Takaahi; Ogete, Yuuji; Chi, Shinto; Win, Chin; Matauura, Shifeo; laei, Takehiro (Kyuahu Sekitan Kozen Gijutau Kankyu Cant., Japan). Saiho to Hoan 1986, 32(7), 349-57 (Japan). Flame propagation velocity, flame propagation length, and the praaaure of coal dual exploeion* were studied to clarify -the effect of the coexistence of 4% CHi [74-82-8], An enclosed exploeion chamber of 3.5 L in capacity waa uaed to meaaure the max. explosion praaaure. Seven kind* of cuaJ dual from Chinaae coal and one from Japanese coal were uaed in the expt. The min. limit of coal duat coocn. at which an exploeion can propagate through the model gallery decreaae* with tne presence of CH. gaa in the gallery atm. TTe flame propagation length become longer and the flame propagation velocity higher in compariaon to an atm without CH* Tne max. praaaure of the coal duat axploaion in the encloeed exploeion chamber become higher due to the preaence of CH*. 106; 55131f Paraonal expoeurea, indoor and outdoor air con= centrationa, and exhaled breath concentratlona of aelected volatile organic compound* aaeaaured for (00 reaident* of New Jeracy, North Dakota, North Carolina and California. Wallace, Lance A. (Energy Environ. Pol Cent., Harvard llniv., Cambridge, MA 02138 USA). Toxicol. m>tron Chem 1886, 12(3-4), 215-36 (Eng). Expoeurea to 20 volatile org. compd* were meaaured in peraonal air, outdoor air, drinking watar, end breath of 600 reeidente of New Jeraey, North Carolina, North Dakota, and California. Participants were aelected randomly to repreaent 700,000 inhabitant* of 7 cities. Participant* carried a peraonal monitor to collect two 12--h air samples and gave breath sample at the end of the day. Two coneecutive 12-h outdoor air aamplea were alau collected on identical Tenax cartridge* in the backyards of tome of the participant*. Of the 7500 aamplea collected, 2000 were quality control aample*. Eleven compd*. were often present in air. Personal expoeurea were conaietently higher than outdoor concna. Indoor source* appeared responsible for much of the difference. Breath concna. also usually eiceeded outdoor concna. and correlated more strongly with personal exposures than with outdoor concna. Some activities (eg., smoking, visiting dry cleaners or service station*) and occupations (e.g., in chem., peint, end plastic plants) were aaaoed. with significantly elevated expoeurea and breath levels for certain toxic cbems. Residence near major point source* did not affect exposure. 106; 55132g Mortality (tody of PVC manufacturer* in Italy: design of tne study and first results. Belli, 8tefeno; Comb*, Pietro; Regciani, Antonio: Piraatu, Roberta; Bertazzi. Pier Alberto; Foe, Vito; Maltom, Ceeart; Marina, Alceete; Vigotti, Maria Angela (1st. Sup. Sanita, Confineti, Romi, Italy). Aequo Aria 1886, (9), 983-8 (ltal). A cohort study is described of the mortality and expoeurea of 5000 polyfuinyl chloride (PVC) [9003-88-2] manufg. workers in 9 Italian plant* Results are presented for 3 plants representing --25% of the total cohort. In Ferrara, a statistically significant excess of deaths, in comparison with the Italian population mortality, from lung cancer and all malignant tumor* was detected, and the best pathoL evidence indicated 4 liver tumors. In Rosignano and Ravenna, the no. of obad. deaths was amall and no conclusions can be drawn about cancer mortality. 106: 85133b Headspace gas-chromatographic method for de= termination of henxene in blood; the basis for a biological monitoring procedure. Renting, Helma; Heberer, H. (AHZ Chem., DDR-4220 Leuna, Car. Dem. Rep.). Z Getamle Hyf Ihrt Grtntgeb 1888, 32(9), 6S2-5 (Ger). The detection limit* of a bead*pace gas chromatog CtH* [71-43-2] detn.. for occupational health control of worfcen exposed to CsH*. are lOOnM C*H/L blood for manual sample injection and 25nM/L for automatic injection. The precision of C*H* detn. was 5-15% (at 100-32,000nM/L Mood) and 4-10% (at 25-30.000nM/L Mood) for manual and automatic sample injection, reap The method is also applied for the detn. of other solvents (eg. PhMe [188-88-3]) in blood. 106: 55134j Enviresmental and occupatioBal expMure to in= organic arsenic. Vahter, Marie (Natl. Inst. Environ. Med., Stockholm, Swed.). Aero Pharmacol. Toxicol., Suppl 1888, 59(7), 31 4 (Eng). In humane. A* it excreted in the urine as inorg. As(III) and A(V) compd*., mclhytammic acid (I) [I24-SK-3], and dtmcthylanunu acid (II) [76-60-5]. The concna. of these conipda. in the urine of worker* expoeed to AaiOi at a nonferroua xmeller ware higher than m the general population, but the ratios of I and II to inorg. As were eimilar, suggesting that methylation is not aatd- at the exposure levels of smelter workers.. 106: 65135k Synergistic neurotoxicity of carbon tetrachloride e/carbon disulfide (80/20 fumigants) and other pesticide* la graia storage workers. Peters, Henry A,; Levine, Rosa L.; Matthews, Charles G.; Seuter, Steve; Chapmen, Larry ' (Dep. Neurol., Univ. Wisconsin, Madison, WI USA). Acto Pharmacol. Toxicol.. Suppl. 1885, 59(7), 535-46 (Eng). Dysfunctions of peripheral axons, th>- auditory nerve, the optic nerve, and the eitrapyramidal system among grain storage worker* occupationally **P*"od to CCL and CSj are CSa done-related. The chelating ability dttlhyl dithiocarbamatc [147-84-2] derived from CS-, and its ability to increase Cu and 2in within the central nervous system suggest Cu intoxication and may sxplain the sxtripyraimdai symptoms. Synergism of CSs and CCli in the prodn of neurntoxir symptoms cannot be ruled out. 106; 65138m Emergency eyatems, their application and their implementation. Von Brecht, Richard; Clark, Steve. Scharringhausen. Don (M. W, Kellogg Co., Houston, TX 77046-0395 USA) Ado Inttrum 1885, 40(2), 1201-10 (Eng). The recommendation* are given tor designing, application, and implementation of practical, reliable, and safe emergency systems to provide safety and protection of equipment and processes. The guidelines for providing aafe and reliable combustion safety controls for gas-fired burners on furnace* and heaters are also presented. 106: 55137n Microprocessor-bated aafety systems designed far fire and gas and emergency ahutdown application*. Wilkinson. James A.; Balls, Basil W. (Ind. Control Serv. Ltd., Maldon/Esaex. UK). Ado Inetrum 1885, 40(2), 1211-21 (Eng). The use of programmable controllers in aafety systems designed for monitoring of haxards ctused by accidental release of flammable or toxic materials is discussed with regards to elimination of unrevealed, or fail-danger faults. A fault-tolerant microprocessor-bated safety system designed using safety engineering principles is described Modular hardware and software used in the system enable flexible application without impairing the 99.999% availability of the safety system. 106: S5138p Role of expert systems In disaster prevention. Rajaram, N. S.; Tsehsie, Haile (Ind. Eng. Dep., Univ. Houston. Houston, TX 77004 USA) Ado Imtrum 1885, 40(2). 1471-4 (Eng). The feasibility of improving industrial plant operation safety by incorporating expert systems for automatic control of information processing functions, csp. those dealing with emergency situations, is discussed and demonstrated by the use of prototype ESCPEM (Expert Syitero for Chem. Plant Emergency Management) system. The ESCPEM system deals with feedstock failure, circulating gas failure, coolant failure, fuel system failure, and instrumentation air failure. The system is interactive and leads the user through a question and answer session and states its conclusion. 106: 5513Sq Asthma caused by isocyanates. Beur, X. (Med. Klin., Univ. Muenchen. D-8000 Munich, 70 Fed. Rep. Ger.) Allergologit 1886, 9(11), 487-96 (Ger). Epidemiol, survey showed recurrent exposure-related asthma attacks and chronic pulmonary obstruction among isocyanate-expoaed worker*. In some cases there was evidence of hypersensitivity pneumonitis. IgE-medisted sensitization was detected by skin and radioallcrgosorbent tests in ~ 14% of symptomatic worker*. The most reliable diagnose* of anate-induced bronchopulmonary diseases were obtained by the [26471-82-5}- provocative test. 106; 55140b Relation between pathologies! grading and lung liber concentration in a patient with a*be*tool*. Gybeth, B.; Skaug, V. (Inst. Occup. Health, 0033 Oslo, 1 Norway). Br. J Ind. Mtd. 1888, 43(11), 754-9 (Eng). The fiber concn. and eztent and severity of fibroei* were analysed in 48 specimen* from the left lung of a patient with asbestos!*. Two different methods of fiber anal, were used. The results obtained by transmission election microscopy were 2-2-5 times higher than tbcee obtained by SEM. Low-temp -ashed samples showed on av. twice the no. of fibers after wet digestion The transmission electron microscope detected considerably shorter fibers than the scanning electron microscope. Low-temp, ashing also produced shorter fibers compared with the wet-digeetion procedure. A statistically significant correlation between fiber concn. and the grade of fibroeii was found only for low-temp.-aahed samples analysed using the transmission electron microscope Dividing the lung into 9e anatomical compartments and pooling the grade of fibrosis and the fiber concn. data within each compartment produced better correlation. 106: SSMlj Formaldehyde and the risk of squamous eel) carcinoma of the sinonasal cavities. Olsen. J. H.; Asnees, S. (Danish Cancer Society. Inst. Cancer Epidemiol., Copenhsgen. DK-2100 Den.). Br. J. Ind. Mtd. 1986, 43(11), 769-74 (Eng). A study of hietol. verified cancers of the nasal cavity, paranasal ainuies, and nasopharynx, and cancer controls diagnosed in Denmark between 1970 ana 1982 was conducted to det. the importance of occupation^ exposure to HCHO [50-00-#]. Information on jnh history for cases anti mnlnils was derived from n iwiIhhuiI dnln linkage system and expisiure to HCHO and wissl dual wms assessed by industrial hygienists unaware of the case-control status of the patients. The exposure rates for HCHO among male and female controls were 4.2% and 0.1%, reap. After proper adjustment for contemporary wood duat exposure, relative risks of 2.3 for squamous osll carcinoma and 2.2 for adenocarcinoma of the nasal cavity and paranasal sinuses were detected among men who have ever been expoeed to HCHO in their job compared with those never expoeed. The introduction of a 10 yr latency period did not change the risk eats, substantially It was considered unlikely that the results were due to bias or miaclassification of exposure although the elTect of change could not lie excluded. 106:55142k Occupational factors and pancreatic cancer. Norell, S.; Ahlhom. A.; Olin, R ; F.rwald. R.; Jecohwin, G ; Lindherg-Navier, I.; Wiechel. K. L. (Dep. Epidemiol., Netl. Inst Environ. Med., Stockholm, Swed.). Br J Ind M-d 1886, 43(111. 4 _l5l$~477 Sampling and analytical method* tot the determine- The scute toncitv of acrylonitrile is relatively high in tests on snimsls The lipn of monochloroacatic acid in air- Mason D W Dillon H K Glaser first acute symptoms produced at low concentrations include eve irritation p* American Industrial Hygiene Association Journal Jan 1986 Vo(47 sneezing headache nausea weakness and vomiting Acute exposure to high No 1 p 14-21 Wus 9 ref lln English! (^onochioroacetic acid IMCAi is collected on silica gel desorbed with water (nd analysed bv ion chromatography The method has been validated in the concentration range of 0.35 to 29mg/m3 in 3L air samples The capacity of Ihe silica gel tubes allows for up to 8h of sampling at concentrations 40mgrm3 There are no significant interferences from glycolic acid dichloro- acetic acid trichloroacetic acid fluoride or chloride compounds or wBter va pour. The effects of temperature humidity, sample storage time and analyti cal parameters were minimal '45804' er concentrations causes profound weakness respiratory distress and as phyxia Acrylonitrile can be absorbed through the skin Metabolism of acrylon rtrile liberates cyanide Acrylonitrile is teratogenic in rets and hamsters Aery lonitrile is mutagenic induces breaks in DNA strands and causes unsche duled DNA synthesis sister chromatid exchange and cell transformation Ac rylonitrile is carcinogenic in rats Epidemiological studies of workers exposed to acrylonitrile supply limited although consistent evidence of carcinogenici tv in human Thus the carcinogenic properties o< acrylonitrile should be the biological effects used in establishing an occupational exposure limit 145838 CIS 86-678 Evaluation of an ISO draft proposal for sampling and analyst* of chlorinated hydrocarbon solvent vapors in workplace atmospheres. Spee T American Industrial Hygiene Association Journal jan 1986 Voi 47 No 1, p.27-36 lllus 8 ref (In English* The ISO proposed method (ISO/TC 146/SC 2/WG4 N41I was evaluated bv means of a round-robin test Samples were taken bv 11 participants in 6 countries A statistical evaluation of the results showed that improvements were necessary for the determination of tetra and trichloromethane For the other 3 compounds (1,1,1 -trichloroethane, trichloroethylene tetrachloroethy- lene) repeatability and reproducibility were sufficient. Possible error sources and possibilities of improving the method are discussed. 145806) CIS 86-684 Sulfur dioxide or sulfurous anhydride (Dioxyde de soufre ou anhydride sulfureux1 Promosafe Mar -Apr 1985 Vol 12 No.2 p 167181 34 ref (In French1 This gas is colourless asphyxiating toxic snd has highly irritant properties As one of the most widespread and dangerous atmospheric pollutants it has been chosen bv specialists to serve as the reference pollutant. Aspects cov ered in this data sheet identification production uses pollution sources physical and chemical properties detection and determination in air and at the emission leve1 explosion and fire risks health risks, damage to vegeta tion and materials regulations in effect in Belgium emergency measures medical supervision preventive measures 145842' R&S 002866 CIS 86-679 A solid sorbent air sampling and analytical procedure for methyl-, dimethyl-, ethyl-, and diethylamine. Elskamp C.J . Schultz G.R, American Industrial Hygiene Association Journal Jan 1986 Vol.47 No1.p41-49 lllus Href tin Englishi The title compounds are collected using sorbent tubes containing Amberlite XAD-7 rasm coated with the denvatising agent 7-chloro-4-mtrobenzo-2- oxa-1,3-diazole and analysed by high pressure liquid chromatgraphy with a fluorescence and/or UV'visible detector All 4 amines can be monitored simul taneously and neither collection nor storage is affected by humidity Samples are stable at room temperature for at least 2 weeks. The method is valid for concentrations ranging from 0.5 to 30ppm. based on a 10L air sample vo lume. I45807i CIS 86-680 Hsalth effects of nitrogen dioxide end oxidants. Lindvall T. Scandinavian Journal of Work. Environment and Health. 1985. Vol 11, suppl.3. p.3-9 59 ref. (In English) This document is intended to serve as e basis for establishing Swedish air quality standards The minimum adverse effect level for human short-term exposure is estimated to be 900pg/m3 for nitrogen dioxide and 200pg/m3 for ozone These values should be lower for sensitive persons Large safety factors should be added to these values before they are used for air pollution control purposes. 145819) CIS 86-681 Evaluation of exposure levels of vanadium in 3 groups of workers by urinary vanadium monitoring (Evaluation de l intensitt d exposition au vanadium de 3 groupes de travailleurs par le dosage du vana dium urinaire). Buchet J.P.. Lauwerys R,, De Maere E.. Desloovere J,, Casier P. Cahiers de mMecme du travail - Cahiers voor arbeidsgeneeskunde. 1985. Vol.22, No.4. p.247-254. lllus. 10 ref. (In French) This study involved 3 groups of workers with potential exposure to vanadi um: I - 11 men whose work included chimney sweeping and the mainte nance of domestic oil heaters: 11-17 men exposed to vanadium dust used in the manufacture of special steels: III - Subjects whose work involved the maintenance of an oil furnace in a thermal power station. The largest absorp tion of vanadium was among workers in group II. Vanadium contamination of the air in the power station during furnace maintenance was considerable (more than 50`/o of the measurements by personal samplers showed air con centrations of more than 70jig/m3). but appropriate preventive measures led to very low levels of vanadium absorption by the workers. Workers in group I did not seem to be exposed to significant levels of vanadium. i45S29i CIS 86-682 Isotschophoretic determination of thiodiglycolic acid in the urine of persons exposed to vinyl chloride (lzotachoforetick stanoveni tiodiglykolovi kyseiiny v moil u lidi exponovanych vinylchlondu). Kfrvtnkovft L. Boiek P,, Samcov* E. Pracovni Ukafstvi. May 1984. Vol.36. No.5. p.163-165. lllus. 6 ref. (In Czech) The vinyl chloride metabolite thiodiglycolic acid can be determined by apply ing untreated urine samples (5jiL) to the columns of a commercial isotacho- ^horesis apparatus. The method is suitable for exposure tests In the urine of Bxposed persons, concentrations were 1.65-7.45pmol thiodiglycolic acid/ mimol creatinine. In non-exposed persons concentrations were 3.0|tmol/ mmol creatinine. i4583Ei CIS 16-683 Nordic Ixpartftroup for Documentation of Threshold Limit Values - SB. AcryianilHIs Mofdiska expertgruppen for gransvir- desdokumentation - 55 Akrylonitril). Alexander J. Arbete och Malsa 1985:4 Arhetarskyddsstvrelsen Publikationsspiyice i7t Soins Swede-i `985 CIS 86-685 Ethylene oxide (Oxyde d ithylene), De Craecker W Promosafe May-June 1985 Vol 12 No 3 p.265-276 lllus 34 ref (In Frenchl Technical data sheet Ethylene oxide is a highly flammable and explosive gas that has already caused major accidents It is included in the EEC Seveso Dir ective, which became effective in Belgium on 1 Feb. 1985. Recent discover ies indicate that the substance is more toxic than previously thought and that it has mutagenic and carcinogenic properties, leading occupational hy gienists to recommend a lowering of the TLV from 10 to Ippm The introduc tion. in the near future, of a Belgian standard on the safe utilisation of ethylene oxide for sterilisation in medicine will contribute to its safe use 145844' 015 86-686 Vinyl chloride (Chlorure de vmyle) Promosafe. Sep.-Oct 1985. Vol. 12, No 4. p.364-376. lllus. 48 ref (In French) Vinyl chloride, used heavily in the plastics industry, is carcinogenic, inflamma ble and toxic. Aspects treated in this technical information note: preparation uses, physical and chemical properties detection end determination, explo sion and fire risks, health hazards (acute and chronic poisoning, carcinogenici ty. teratogenicity, mutagenicity), emergency measures, medical supervision: Belgian regulations, recommendations for storage, handling of the product and waste disposal. i45847i CIS 86-687 Evaluation of the carcinogenic rimk of chemicals to hu mans. Allyl compounds, aldehydas, epoxides and peroxides. IARC Monographs 36. International Agency for Research on Cancer. 150 cours Al bert Thomas. 69372 Lyon Cedex 2. France, Feb. 1985.369p. lllus. Bibl. Price: USS25.00: SF.70.00. ISBN 92-832-1236-3 (In English) Conclusions of a meeting of experts (Lyon France, June 1984). There is limit ed or inadequate evidence for the carcinogenicity of allyl chloride, allyl isothiocyanate. allyl isovalerate and eugenol in animals: in the absence of epidemi ological data, no evaluation of human carcinogenicity could be made. There is sufficient evidence that acetaldehyde is an animal carcinogen, but in adequate evidence of its carcinogenicity in humans. Evidence of the carcino genicity of acrolein and malonaldehyde in animals or humans is inadequate or absent. There is sufficient evidence for the carcinogenicity of diglycidyl resor cinol ether, ethylene oxide propylene oxide and styrene oxide in animals, but only ethylene oxide can be identified as probably carcinogenic" in humans Evidence of the carcinogenicity of benzoyl, hydrogen and lauroyt peroxides is limited or inadequate for animals and inadequate or absent for humans. 145857) CIS 86-688 International symposium on occupational axpocura limits. ACGIH Annals Vol. 12. American Conference of Governmental Indus trial Hygienists. 6500 Glenway Avenue. Building D-5. Cincinnati. OH 45211. USA. 1985. Vol. 12. 389p lllus. Bibl. ISBN 0-936712-62-7 (In English) Proceedings of a symposium held in Copenhagen. Denmark, on April 16-19. 1985 and sponsored by the ACGIH. WHO and Novo Industri A/S. Aspects cov ered: ACGIH TLVs. their background, current developments, impact: develop ment of occupational exposure limits in Europe: exposure limits for short and extended work intervals and for special compound classes; special problems in using airborne exposure limits; exposure limits for physical agents. The pro ceedings of activities in 3 workshops on airborne exposure limits, biological exposure indices and exposure limits for physical agents are also included. (458591 CIS 86-689 The role of oerfy detection in the prevention of occupa tional dieease - A review of work in the People'! Republic of China. Gu X Scnn-iinav:-' ,`''Urna, of Wen ---- uogtth iggc y I Cknicel statistical and comparative atudiea of 145 casaa of vibration diaeaae CIS 86-10S8 Kinetics of fluorine elimination in exposed workers ! - and 60 control*. A positive correlation was found between the elbow-ioint disorders and the patients ages in both groups, which implies that the ef- (Kinetika na eliminirane na fluor pri eksponirani rabotnici). tuturkova R. Pro blem/ na higienata July 1984. Voi.9, p.73-78.4 ref. (In Bulgarian) bow-jomt disorder will m no case fall under the category of vibration-specif ic disorder. In addition, no remarkable correlation was recognised between spasmodic albedo (whiteness), elbow-joint disorder and age distnbution. The incidence of abscess was 14 cases (9.6V*) in the vibration-affected group and 1 case 11.67V*) in the control group. The disorder as such cannot be regarded as specific to vibration disease, but it can be useful information for diagnosis. weaoii The 14-day kinetics of fluorine (F) elimination in unne was followed in 24 op erators from a plant for phosphorus fertilisers. The concentration of F in unne was determined at the beginning, after 6h and during the last 2h of a working shift on 4 successive days, and after 64h without exposure. Gaseous F com pounds in air were also determined in parallel. A potentiometric method with an F-selective electrode was used in both urine and air analyses. A clear ten dency to increased exertion was established by the end of the working shift and in the course of the working cycle. The rate of F elimination was highest CIS 86-1084 Case of multiple myeloma in a vinyl chloride polymeri dunng the last 2h of exposure. It was highest in workers in a superphosphate sation worker. Sakakibara F., Kawamura T,, Fukumura A. Japanese Journal plant, lower in workers in a phosphoric acid plant and lowest in workers in a of Traumatology and Occupational Medicine. Oct 1984, Vol.32. No. 10. tripolyphosphate plant The concentration of fluoride ions in urine for the 3 p.737-740. Ulus. 9 ref. (In Japanese) groups of workers was higher than control values, both after 6h and during Case report of a 50-year-old male with multiple myeloma. The patient had the last 2h. <4*3ibi been engaged in the cleaning of vinyl chloride polymensation chambers in a chemical factory from Nov. 1964 to Aug. 1968. He was hospitalised in Nov. 1981 because of a compression fracture of a thoracic-lumber vertebra, and marked hyperproteinaemia was found on admission. IgG-kBppa type M-pro* tein was detected by electroimmunodiffusion. He was treated with recombi CIS 86-1090 Experimental study on Endodan for teratogenicity and ambryetoxicity (Eksperimentalno proubvane na endodan zb teratogennost i embriotoksiCnost). Vergieva T. Probtemi na higienata July 1984. Vol.9. p.88-95. Ulus. 13 ref. (In Bulgarian) nant alpha interferon followed by melpharan. cyclophosphamide, vincnstm An experiment was carried out on albino rats for assessment of the effect, and prednisolone, and has been fairly well maintained for 4 years. 1463041 during gestation, of the fungicide endodan (ethyiene-thiuram monosulfide) on the intrauterine and postnatal development of the progeny. A low terato CIS 86-1085 A study on residues of organochlorine pesticide* end genic and embryotoxic activity was found after s single treatment with 1/ n PCBs in the human body. Takamatsu M.. Oki M.. Maeda K,, Suenags T,, 2LDso on the 13th day of gestation. The preparation has a pronounced cumu l Sakurai T., Ysmads T. Journal of the Japanese Association of Rural Medicine lative effect on daily administration of 1/5. 1/10 and 1/20LDso, manifested by J July 1984, Vol.33, No.2, p. 153-158. Ulus. 10 ref. (In Japanese) clinical symptoms and death of a part of the pregnant animals. Behavioural abnormalities were observed in the progeny but no changes in viability and v The BHC (lindane). DDT and PCB (polychlorinated biphenyl) levels in the plas weight gain during the postnatal period. 463i9i ma of 127 farmers in Japan and 21 in China were examined. |)-BHC, pp - DDT and pp'-DDE were detected in all of these specimens. Regional differen ces in the Japanese residual level were found, and the Japanese levels were lower than the Chinese. These differences seem to be related to the history of the use of BHC and DDT. PCBs were detected in all of the Japanese (1.1- 22.8ppb in the plasms), whereas the PCB levels of 15 Chinese women were < 1 ppb and some Chinese men showed high PCB levels. mssob) CIS 86-1091 Results of a longitudinal study of coronaropathias in relation to occupational carbon sulfide exposure (Rezultati ot longitudinalno proubvane na koronaropatii pri profesionalno vizdeistvie na serovfiglerod). Dimitrova M.. USevs G,, Pavlova S. Problem! na higienata. July 1984. Vol.9, p.107-111.2 ref. (In Bulgarian) A 7-year longitudinal study was carried out on the risk of coronaropathy in t n 3 CIS 86-1086 Change* in the functional state of the visual analyser in female workers checking ampoules (Promeni viv funkcionalnoto sastojanije na zritelnija analizator pri kontroliorki na ampuli), Kojieva V., Rizova workers exposed to carbon disulfide. An increased number of the subjects with manifestations of positive and probable ischaemic heart disease was ob served, no increase being found among the controls. The significance of car bon disulfide as a basic risk factor to and as a potentiator of the effects of R., Zlateva V. Problemi na higienata July 1984, Vol.9. p.9-16.5 raf. (In Bulgari smoking and hypertension still cannot be determined. (463201 an) r The state of the visual analyser and its functional changes due to the work CIS 86-1092 Contact dermatitis in hairdressers. Nathercott J.R., performed were studied in 60 female workers engaged in checking the quali MacPheraon M., Choi B.C.K.. Nixon P. Contact Dermatitis, Fab. 19B6. Vol. 14. ty of ampoules in a pharmaceutical plant There was a high percentage of No.2. p.73-79.18 ref. (In English) complaints about the visual system as well as high visual strain at the end of Eighteen cases of hand dermatitis in hairdressers seen over a 5-year period the working day. due to the small size of the objects to be checked end the ir are reviewed. The diagnosis in these patients are discussed with reference to If regular illumination of the visual field, as well as to the high rate of work. Pa thological changes were found in die anterior segment and the fundus of the Other studies of hand dermatitis in hairdressers. Contact clergy due to paraphenylenediamine and related hair dyes was the presenting complaint in eye in a great number of the workers. It is recommended that workers have younger hairdressers, while formaldehyde allergy occurred in those who were thorough eye examinations before employment and at regular intervals the older. The prognosis in the former group of workers with respect to conti reafter, end thet workers be given e lOmin break every 2h (away from the nued employment in the trade tended to be poorer than in the latter. Follow workplace if possible). Hesisi up revealed that hand dermatitis often resulted in the worker not continuing to work in the hairdressing trade. <40325) CIS 86-1067 Changes in moms biochemical indices in workers ex- poeed to vinyl chloride and dichloroethane (Promeni v njakoi biohimiC- CIS 86-1093 Principles of toxicokinetic studies. Environmental ni pokszateli pri rabotnici eksponirani na vinilhlorid i dichloroetan). Spasovski Health Criteria 57, World Health Organization. Distribution and Sales Service. I M.. Stantev S.. Nosko M,, Zlatev Z.. Popov T. Probtemi na higienata. July 1211 Gentve 27. Switzerland. 1986. 166p. IHus. Bibl Price: SF.14.00. ISBN 1964, Vol.9, p.50-58.4 ref. (In Bulgarian) 92-4-154257-8 (In English) I Laboratory investigations were carried out on 280 workers exposed to vinyl Aspects covered in this document: analytical methods: absorption; distribu chloride (VCh) and dichloroethane. Some haematoiogical indices and liver tion; binding; metabolism; excretion; kinetic models; toxicokinetic methodol function were examined. The significance of elevated transaminase and trans ogy in the assessment of human exposure; assessment of toxicokinetic stu peptidase levels as a diagnostic sign of VCh disease was confirmed. An inhibi dies. (483291 tory effect of VCh on the mixed-function oxidases in the exposed workers was observed for the first time. A new case of VCh disease was diegnosed. in which the combined effect of VCh and dichloroethane wee apparent CIS 66-1094 Pathological study of magnetite miners' pneumoconi osis. YuS. Industrial Health and Occupational Diseases. 1965, Vol. 11. No.5. Mesiai p-271--275. IHus. 3 ref. (In Chinese) R&S 002867 CIS 86-1668 Quentttathre assessment of the irritating affect of butenoi, octanol, acetaldehyde and arotonaldehydc on human skin (KcMestveno opredeksne ns kotnoto draznalto dejstvie na butanol, oktanol. acetaldehid i krotonov aldehid v8rhu hors). Bajnova A.. Madhinov N. Problem! na higienata. July 1984. VoL9. p.66-72.17 ref. (In Bulgarian) A method was elaborated for quantitative assessment of the irritating effect of 4 solvents after a 24h contact with healthy subjects. The irritating effect of octanol is significantly weaker than thet of butanol Crotoneldehyde is the strongest irritant The threshold skin irritating concentrations are 12V* octan ol. 7.8% butanol, 1-2*/# acetaldehyde end 0.12V* crotoneldehyde in vegetable oil The following allergic concentrations in vegetable oil are recommended tor epicutaneoue tasting of subjects with occupational or everyday home con tact aiergy to paints, varnishes, glues, cleaning and defatting agents and anti- oorrostve preparation*: 6% octanol 4*1* butanol. 0.6V* acetaldehyde and 0.06V* crotnnaldehvde, 1463171 Pathomorphological changes and pathological classification of pneumoconio sis wore studied in post-mortem lung materials from 60 magnetite miners. The pathomorphological changes characteristic of magnetite miners' pneu- moconioeis were; 1) formation of atypical silicotic nodUea and mixed-type pneumoconiotic nodules in addition to the typical onion-Bra nodules: 2) oc currence of interstitial diffuse and pneumoconiotic fitorooi* mainly around small bronchi and their associated small vessels. Suggestion* on pathologi cal diagnosis and classification of magnetite miners' pneumoconiosis are of fered <463611 CIS 86-1096 Frequency of lymphocyte sister chromatid ex changee in coke oven workers. Yuan C. Industrial Health and Occupa tional Diseases. 1985. Voll 1. No.6. p.336-338. (In Chinese) The analysis of sitter chromatid exchange (SCE) might be a useful technique for the study of genetic damage in humans exposed to environmental muta gens and carcinooens. In he ifpsert shiriv. tvm-1--vte sister chroma-'d * -