Document omNGdjdy1O8mDw8N5MeaNQv8o

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MV 3303 UCC 065046 000X9225 SCLERODERMA PAGE 1 1 TI Destructive flbroete [editorial], LA - Eng MH - Connective Tlssue/pethology i Dupuytren'* Contrecture/et1ology HH - Human ; Muscular D1xeases/pathology MH - Scleroderma, System!c/et1ology ; Wound Healing SO - Br Med J 1977 26 Mar;1(6064):792-3 2 TI - Graft-versus-host reactions and autoimmune disease [editorial) LA - Eng MH - Adolescence ; Autoimmune Dlseasas/aetiology i Child ; Female m - *Graft vs Host Reaction i Human 1 Male MH ~ Scleroderma, Systemie/etfology SO - Lancet 1978 4 Mar!1<8062):480-l 3 AU - Barskl'l VI TI - [Latent forms of osteomyelitis In children and collagen diseases] A - Rus MH - Adolescence 1 Arthritis, Rheumatold/*et1 ology 1 Child m - Child, Preschool 1 English Abstract j Human MH - 0steomyelltl*/*compl1cat lons/diagnosis MH - Rheumatic Heart 0iseese/et1ology tW - Scleroderma, Systemie/*et1ology SO - Khlrurgi(a (MosK) 1978 Dec!<12)<51-5 4 AU - Bouvet JP ; Le Parc JM 1 Auquter L TI - [Metestaxi chordoma with extensive cutaneous sclerosis] LA - Fra MH - Adult ; Case Report J Chordoma/compl1cat lons/pathology ; Hunan MH - Male ; Neoplasm Metastasis PM - Scleroderma, Systemic/*etfology/pathology i Skin/pathology MH - Spinal Naoplasms/scomplicatlons/pathelogy SO - Ann Med Interne (Paris) 1977 Nov;128111)<877-61 5 AU - Brouse NL TI - Natural fIbrtnolysis. LA - Eng MH - *F1br1nolys1s/drug effects 1 Hinan MH - Scleroderma, Clrcumscrlbed/etlology 1 Thrombgphleblt1s/et1ology SO - Am Heart J 1978 Apr;95(4>:417-9 6 AU - Dalxlel JA ; Ulleock GK TI - Progressiva systemic sclerosis In the elderly. LA - Eng AB - There Is evidence to suggest that the Incidence of progressiva systemic sclerosis In the elderly Is more common than in younger age groups. As In younger patients, late onset cases may have minimal skin changes and this can cause difficulty In diagnosis. The ease histories of 2 patients are presented to Illustrate these points. MH - Aged ; Case Report i Female 1 Human MH - Raynaud's Disease/complieatlons W - Scleroderma, Sys tem 1 c/d1 agrtos I s/et 1 ology 00019226 3CLEROOERHA PAGE 2 SO - Postgrad Med J 1979 Mm* 155(641)<192-3 065047 7 AU - Oobxhanskl'1 SX TI - [Familial cases of scleroderma] JLA - Rus MH - Adult I Case Report 1 Child 1 English Abstract 1 Female 1 Ikaian (9i - Scleroderma, Clreumaerlbed/etiology/afamlllal > genetic MH - Scleroderma, Systemic/etiology/afamiltal 6 genetic SO - Vestn Dermatol Venerol 1979 May 1(5)<40-2 5C SSS 8 2 2 2 `CSS 00019226 SCLERODERMA PAGE 2 SO - postgrad Mad J 1979 Mari55(641):192*3 - Dobzhanskl*1 SI - (Familial coles of scleroderma] - Pus - Adult i Caaa Report ; Child 1 English Abstract ; Female i Human - Scleroderma> C1rcumser<bed/et1ology/*fam111al A genetic - Scleroderma* Systemic/etiology/afemillal A genetic - Vestn Dermatol Venarol 1979 May!(5):40-2 - Fenyk JR Jr i Smith CM i Harkentln PI ; Krlvlt H i Golt* RH - Neely JE i Nesblt ME i Ramsay M( i Cocci a PF > Kersey JH - Sclerodermatous graft-versus-host disease limited to an area of measles exanthem. - Eng - A female patient with severe Idiopathic aplastic anaemia received a successful bone-marrow transplant from her HLA-1 dent 1 cal mlxed-lymphocyte-culture-cempatlbla* brother. S months after transplantation she had localised cutaneous measles. Chronic sclerodermatous changes developed which ware Indistinguishable from chronic graft-versus-host disease and were limited to the areas of the original exanthem. Interaction between viral infection and minor histocompatibility differences probably resulted In graft-versus-host disease in this patient. - Adolescence > Anemia* Aplastic/therapy - Bone Marrow/atransplantatlon i Case Report > Female - "Graft vs Host Reaction i Hunan i Lymphocytes/immunology * Male - Measles Virus/Immunology * Measles/aimmunology - Postoperative Compl1 eat 1on*/"et1ology - Scleroderma* Systemic/aetiology * Skin/Immunology - Transplantation* Isogeneic i Support* U.S. Gov't* Non-P.H.S. - Lancet 1970 4 Mar 11(0062).*472-3 - Fessel MJ - Scleroderma and welding (letter!. - Eng - Adult i Female i Hunan ; Male ; Occupational Diseases/aetiology - Scleroderma* Systemle/aetlology 1 "Melding - N Engl J Med 1977 30 Juni296126):1537 - Fries JF - The mlerovaicular pathogenesis of scleroderma: an hypothesis. - Eng - Human ; Hypertens 1on/compl1cat1 ons/phys1opathology - Mleroelreulatlon/aphyslopathology - Scleroderma* Systemic/setlology/phystopathology - Ann Intern Med 1979 Nov 191(5):700-9 8222Cm 822C38 82222222 ucc 065048 ijtf 00019227 SCLERODERMA PA6E 3 11 AU - Furst DE ; Clements PJ i Graze P ; Gale R i Roberts N TI - A syndrome resembling progressive systemic sclerosis after bone marrow transplantation. A model for scleroderma? LA - Eng AB - Six long term survivors of bone marrow transplants developed a syndrome similar to progressive systemic sclerosis (PSS). Cutaneous Involvement (6/6>, pulmonary disease (4/6) musculoskeletal Involvement (4/6)* keratoconjunctlvltls/positive Schlrmer's test (4/6)i Raynaud's phenomenon 12/6), and renal and cardiac disease (1/6) were similar to findings In PSS patients. T and B lymphocyte counts and functions were also similar. This PSS-lIke syndromei Including visceral involvement* after bone marrow transplantation lends support to an Immunologic hypothesis of the pathogenesis of progressive systemic sclerosis. MH - AntIgen-Antibody Complex > B Lymphoeytea/immunology MH - Bone Marrow/*transplontat1on i Creatinine/urine MH - Graft vs Host Reaction i Human i Scleroderma. Systemic/aetiology MH * T Lymphocytes/immunology MH - Transplantation! Homologous/eadverse effects MH - Support* U.S. Gov't> P.H.S. SO - Arthritis Rheum 1979 AugI22(8)1904-10 12 AU - Gal laseh S I Sloor M ; Schr'oder J TI - (Clinical aspects of pelvic stenosis syn4*ome (Schnelder-FIscher)) LA - Ger AD - Six cases with posthrombotie obstruction of the pelvic veins are reported. These ease reports demonstrate the variability of the clinical symptomatology. In addition relationships between the postthrombotic obstruction of the pelvic veins and hemorrhoids and varicocele are discussed. Therapeutical aspects are reviewed, iff - Adult > Aged i Bandages * Case Report ; English Abstract i Female iff - Femoral Vein ; Hemorrhoids/complications i Human I Iliac Vein MH - Leg Uleer/etiology > Male i Middle Age I Pelvis MH - Selerodermat Circumscribed/etiology iff - Sclerosing Solutions/therapeutic use iff - Thrombophlebit1s/complications i Varleocele/etiology MH - Varicose Ve1ns/*etiology ; Vena Cava* Inferior SO - Hautarxt 197B Aug;29(8>=430-4 13 AU - Gottwald M TX - [Neurologic> neurophysiologic! neuropathologlc and psychiatric aspects of scleroderma. (1st. continuation and conclusion)] (A - Ger' Iff - Adolescence > Adult | Atrophy I Electroencephalography MH - Epilepsy/etiology { Faee/pathology i Female t Human ; Hale MH - Mental Disorders/diagiosfs/etlology f Middle Age Iff - Neurologic Mantfestatlcns t Peripheral Nerves/pathology iff - Scleroderma. Systentc/complicattons/etiology/Rathology MH - Hounds and Injuries/eomplications SO - Z Hautkr 1977 1 AprJ52(7)=399-412 Ucc 065049 oooimo SCLERODERMA PAGE 4 14 AU - 6upta 3 Malaviya AN i Rajagopalan P ; Good RA TI - Subpopulatlons of human T lymphocytes. IX. Imbalance of T call subpopulations in patianta utth prograntv* systemic sclerosis. LA - Eng AB - Peripheral blood lymphoeytaa from twenty patianta with prograaaive ayatamfc acleroaia (PSS) were analyaad for tha numbera and proportlona of B lymphocyte* poaaeasing aurfaea immunoglobulin, calls with Fc receptors, T calls and T calls with receptors for XgM (T mu) or IgG (T gamma). In patients with PSS, B calls and lymphocytes with Fc receptors were comparable in both numbers and proportions to those of the control group. Circulating T lymphocytes were significantly fewer In the patient group. T mu cells were decreased and T gamma cells Increased, resulting in lower T mu/T gamma ratios as compared to controls. This study demonstrates a profound imbalance between T mu and T gamma cells (containing a population of helper or suppressor cells, respectively). These results are discussed In relation to immunodeficiencies observed In patients with PSS. tfi - Animal i B Lymphocytes i Female i Human ; IgG ; Immunity, Cellular MM - Leukocyte Count ; Lymphocytes ; Male i Rabbits ; Receptors, Fc MH - Scleroderma, Systeralc/etlology/etmmunology MH - T Lymphocytes/sclasslffeation ; Support, U.S. Gov't, P.H.S. SO -Clin Exp Immunol 1979 Nov;3C(tl341-7 Herbal B - Scleroderma (progressive systemic sclerosis, P3S)i pathophysiological, clinical and pharmacological aspects of the syndrome. - Eng - Scleroderma Is an uncommon complex disease. The onset Is slow and the progress is chronic. The main pathophysiological changes vary) they affect blood vessels, connective tissue, collagen fibres, cause fibrin deposition and Inflammatory reactions. There may be early oedema and a wide spectrum of organic Involvement. Clinically, all the fibril-containing and connective tissue organs can be attacked In various degrees. The most common organ man!fastatIona are the Raynaud's phenomenon In the arms and hands, vascular fibrosis, stiff and hard facial skin, restriction of Joint movement by perleapsuler hardening, calclus deposition and capsular rigidity. In the gastrointestinal tract muscle atrophy, collagen and connective tissue damage are common, especially at the cardie. Malabsorption may occur. Aggressive pulmonary fibrosis leads to cor pulmonale and respiratory Insufficiency. The liver, kidneys and the endocrine glands are, however, seldom involved. Therapeutic trials have been performed using many different groe>s of drugs: vasedilatating agents, corticosteroids, <b~ug* foirid experimentally to influence connective tissue, thyroxine and a variety of ant(-rheumatic agents. In the last decade best short-term clinical results have been achieved with penicillamine, some vasodlllators, chlorambucil and In recant years with cyclofenll a potent ant(-oestrogen, which has marked connective tissue and collagen metabolism !l ucc 065050 S tags 82222 00019229 SCLERODERMA PAGE 5 Influencing properties. Good therapeutic effects without serious side effects have been achieved. - Cyclofeni1/therapeutlc use i Human Hale ; Middle Age - Penfclllamlne/therapeutlc use - Scleroderma, SystemIc/*drug therapy/etIology/pathology - Skin/pathology - Acta Med Acad Sol Hung 1978!35(3-4):201-11 - Hermler M ; Ml colie JP > Betend B ; Hermler C i Parrot H - Francois R - (An case of acute diffuse selerodarma In an Infant] - Fra - The authors report a case of diffuse scleroderma In a 15 months old Infant. Dermatologic (clinical and pathological) findings are quite typical of the disease. On the other hand, In this case some particular!ties were observed: the age of the Infant (second published case beginning before the age of two); the presence of a durable eoslnophllla, the absence of visceral lesions and of biological abnormal!tels (of auto-immune nature specially), the evolution towards athrepslea and death within one year. Thus, because of these particularities, the diagnosis of scleroderma remains questionable and the diagnosis of progeria has been considered. The affection appeared In the course of a hepatitis leaving a hepatic fibrosis without Inflammatory signs) no conclusion can be dram about the relations between the hepatic affection and the fatal dermatologic disease. - Acute Disease ) Case Report I Diagnosis, Differential - English Abstract ) Eosinophils ) Female ) Hepatftfs/complleat tons - Human ; Infant t Progeria/dlagnosis - Scleroderma, Systemic/dfagnosls/etiology/epathology - Arm Dermatol Venereol 1977 Nov)104(11):725-30 - Horwlts 0 - Raynaud's disease and scleroderma [letter) - *ng - Human ) Raynaud's Dlsease/ecomplleatIons - Selerodarma, Sys ten 1c/**ett ology - JAMA 1979 27 Apr!241(17):l794 - Karl H - (Schneider's and Fischer's pelvic stenosis syrwk-ome (case 27)] - Gar - Adult ) Case Report ) MemosIderosls/etlology i Human - Inguinal Canal ) Hale [ Pelvts/blood supply - Scleroderma, Clrcianscr 1 bed/e11 ology - Thrombophlebltls/ocomplleatlons ) Varicose Velns/etlology - Z Hautkr 1977 1 Aug)52(15):821-2 81222 82222&3g ucc 065051 00019230 SCLERODERMA PAGE 6 SC 3SS S l i i l i i C 19 AU - Kaplan D TI - CScl#roderma--a vascular disease] - Rus - Blood Vaisels/physiopathology ; Human . Intesttnes/blood supply - Kldnay/blood supply i Lung/blood supply - tkiicla, Smooth/physiopathology - Raynaud's Oiieie/compl (cat I ons/physiopathology - Sclarodcrma> Systamfc/atiology i Skin/blood supply - Stomach/blood supply - Tar Arkh 1970;50( 9):102-9 Lauley TJ Pack 6L ; Houtsopoulos HN ; Gratwohl AA - Defssaroth AB - Scleroderma. SJ"ogren-like syndrome. and chronic graft-varsus-host disaasa. - Eng - A patiant with acuta myaloganou* laukamia traatad with an alloganafc bona marrow transplant davalopad acuta graft-varsus-host disaasa mantfastad by savara diarrhea, hepatitis. and a cutanaous aruption. As tha graft-varsus-host disaasa prograssad to tha chronic phase. tha patiant davalopad marked cutanaous sclarosis and symptoms of xerophthalmia and xerostomia. Biopsy of his indurated skin showed features of both graft-varsus-host disaasa and scleroderma. Results of Sehirmer's tests, corneal fluorescent studies, parotid flow-rate tasting, and a lip biopsy ware consistent with 3j"ogren's syndrome. Possibly, activated lymphocytes may have a role in tha pathogenesis of graft-varsus-host disease, scleroderma, and 3j"ogran's syndrome. - Adult I Bona Marrow/transplantation ) Case Report - Chronic Disaasa "Graft vs Host Reaction ; Human - Leukemia. Myeloblastic/therapy i Male - Scleroderma. Cireumscrtbed/"compl1 eations/et1ology/pathology - Sjogren'S 3yndrome/*complicat ions/atiology - Transplantation. Homo1ogous/adverse affects - Ann Intam Had 1977 Dac;67<6>:707-9 - Lebedev DA - Soma possible mechanisms in pathogenesis of systemic sclerodensal - Rus - Call MembreneAnetabolism t Collagan/matabolism 1 English Abstract - Human S Scleroderma. Systarnic/watfology/matabolism - Tar Arkh 1977i49(ll):l-30 - Mattingly PC ! Mowat AS - Rapidly progressive scleroderma associated with carcinoma of tha oesophagus. - Eng - A patiant with scleroderma of recant onset was found to have a carcinoma of tha oesophagus. The rapid progression of tha scleroderma suggested tha possibility that it represented a systemic manifastation of malignancy. SC dS 8 iifc 3 5 S i i i i i i uce 065052 S222E38 8222C 38 8222 00019231 SCLERODERMA PAGE 7 3 Aged i Caretnoma> Squamous Cell/complIeat 1 or* > Casa Report Esophageal Neoplasms/*complteat ions > Female i Human Scleroderma, Systemlc/*et1ology Ann Rhaum Dis 1979 Apr;38(2):l77-8 Mistry CJ ; Nagholikar UL Oeshpanda AK ; Chttale SV Primary systemic amyloidosis presenting as scleroderma: (a case report). Eng Amylotdos fs/'*compl i cat lons/pathology i Casa Report Diagnosis, Differential Human i Male > Middle Age Scleroderma, Systemie/*etfology J Assoc Physicians India 1978 May:26(3):9S1*2, x Montes LF } Gay S ; Miller EJ i Fullmer HM Scleroderma. Eng Adult i Case Report ; Female i Human Scleroderma, ClreumscrIbed/eompl1 cat 1ons/epathology Scleroderma, Systemic/etiology i Skin/pathology J Cutan Pathol 1978 Jun!5i3):i50-1 Penny R Scleroderma: pathogente factors and current management. Eng The aetiology of scleroderma remains trknown. Pathogenetic mechanisms may originate from vascular, collagen or immune abnormalities. These are reviewed and the current management although in the main unsatisfactory may alleviate a number of the distressing symptoms. Blood Vessels/pathology/physiopathology ; Blood Viscosity Collagen/Petabollsm l Human t Microcirculation ; Review Scleroderma, Systemic/et1ology/fmmunology/pathology physiopathology/therapy : Skin/metabolism/pathology Aust NZ J Med 1978)8 Suppl 1`193-8 Rassokhtna PP t Lebedev DA > Parasiuk AF i Grozdova HD Iakovleva 81 [Current state of the problem of pathogenesis of systemic sclarodersMl Rus Acute Disease ; Cell Nsmbrane/aetabolis* t Chronic Disease Collagen/biosynthesis i English Abstract i EptnephrIne/metabolism Human i Microscopy, Electron { Norepinephr1ne/metabol1sm Receptors, Adrenergic/metabollsm ; Scleroderma, Systemle/*etiology Sk i n/pathologyAil tras true tire Ter Arkh 1979;51(7):llA-8 O 3 > "Jf ^ \ 7 3 <3 * ^ ^ 812221? 2SS 8 222 UCC 065053 00019232 SCLER00ERMA PAGE A SC 28 S 222S 3S 8 2 2 2 2 27 AU - Richter M ; Justus J TI - [Sclerodermlform paraneoplastic syndrome during a kidney carcinoma] LA - Ger AB - Sclerodermlformous alterations of the skin are described as paraneoplasla In different malignant tumours. By an own observation sclerodermlformous alterations of the skin are described for the first time as paraneoplasmla In a female patient aged 60 with nephrous carcinoma. The cutaneous efflorescences receded after elimination of the tumour. - Case Report > English Abstract > Female ! Human - Kidney Ncoplasms/ecompl1 eat lons/pathology/surgery i Middle Age Postoperative Complleat lons/radiotherapy - Scleroderma, Systernic/et1 ology/'pathology - Z Gesamta Inn Med 197B 15 Mar;33(6>:i93-5 - Sahl HJ Koebner phenomenon, morphoea, and viral axanthems [letter] - Er>9 - Case Report ; Ch1ckenpox/*complteet1ons ; Child - Exanthema/ecompllcat Ions ; Female i Graft vs Host Reaction 1 Human - Scleroderma, Clrcumscribed/eetlology - Lancet 1970 15 Apr;l(6060>.*032 - Sandhofer M J Frit* J S Altmann H - [Scleroderma, an ageing process? Z. Clinical and Immunological aspects (author's transl)] - Ger - Scleroderma with Its different manifestations Is mainly a disease of connective ttssue and of vascular system. Next the alteration to collagen, which is demonstrable in lesions by decrease of embryonale collagen type III, there are also humoral and cellular phenomens of autoimmunity. In more than 70X of our patients we found antinuclear antibodies, and (n most of them, we found with the leukocytemlgration--inhlbi tlon-test cellular immunphenomenons to RNA, collagen and muscle. There Is a small connection between ageing and Immunological defense and repair, accordingly of immunocytes and fibroblasts. Further more precise characterisation of this cell-compartlments under the aspect of a premature ageing could bring a new understanding in The largely unknown ettopathogenese of scleroderma. - *Aging ; Antinuclear Factors/analysis ! Cell Migration Inhibition - Collagen/metabolism ; English Abstract i Female t Human ; Immunity - Leukocytes i Middle Age ; RNA/Immunology - Scleroderma, Clrcumseribed/physiopathology - Scleroderma, Systemic/ettology/lmmunology/ephystopathology - Aktuel Gerontol 1977 Dee!7(12>:6*5-51 832311 ucc 065054 00019233 SCLERODERMA PA6E 9 S td S 8 2 2 2 2 SC 82223C 30 AU - Simon M ; Berk'o 6 > Schneider I i Slkl'osl C ; K'osz'o F T1 - tHepato-erythropoiettc porphyria manifested by scleroderma and acrosclerosi* In a pair of sibling*] - H<ji - Casa Report > Female ! Karyotyping i Liver/pathology > Male - Middle Age > Porphyrla/compllcattons/afamlllal A genetic/pathology - Scleroderma. System 1 c/e11 ology/*fam 111 ol A genetic/pathology - Skin/pathology - Orv Hat 11 1977 27 Mari118(13):731-5 - Simon N { Berk'o G i Schneider Z - Hepato-erythropolette porphyria presenting as scleroderma and acrosclerosls In a sibling pair. - Eng - Clinical and biochemical data are reported on a sibling pair with clinical and biochemical features of both erythropoietic protoporphyria and hepatic cutaneous porphyria. After many years of photosensitivity the clinical picture resembles systemic sclerosis. - Cose Report i Diagnosis. Differential ; Erythropoies1s ! Female - Human ; LIvar/metebollsm > Mole i Middle Age - Porphyrfa/ediagnosts/famillal A genet 1c/metaboltsm - Scleroderma. Systemie/*at1ology - Br J Dermatol 1977 Jun;96(6):663-B - Splelvogel RL > Goltz RM i Kersey JN - Scleroderma-like changes in chronic graft vs host disease. - Eng - A case of chronic graft vs host disease had scleroderma-like skin changes. Clinical progression was from poikiloderma to scleroderma, and histopathologieal changes and results of direct Immunofluorescence were noted. It Is probable that both cell-mediated (T-cell) and humoral (B-cell) mechanisms contribute to the pathogenesis of the graft vs host reaction, - Adolescence i Bone Harrow/transplantation > Case Report - Chronic Disease I Complement 3 ; Female i "Graft vs Host Reaction - Human t IgA t IgM > Male - Scleroderma. Systamic/etlology/imminology/opathology - Transplantation. Homologous ; Support. U.S. Gov't. P.H.3. - Arch Dermatol 1977 Oet;il3(10):i424-G - Splrer Z I Ills B i Pick IA I Yaren M TI - Localized scleroderma following varicella In a three-year-old girl with IgA deficiency. I* - Eng AB - A three-year-old girl with Isolated IgA deficiency developed localized scleroderma Immediately after varicella Infection. Physiotherapy was started without any drug therapy. Only a minimal clinical Improvement was achieved. The connection between IgA deficiency, viral Infection and collagen diseases Is discussed. tft - Case Report > Chtckenpox/ecompllcat tens I Child. Preschool g 822231 ucc 065055 II 00019234 SCLERODERMA PA6E 10 MH - Dysgammaglobulfnemia/ecomplieations ; Female ; Human W - IgAAdeficiency i Scleroderma, CireumscrIbed/etiology/pathology MH - Skin/pathology SO - Acta Paediatr Scand 1979 Sep;68(5}:7B3-5 m 34 AU - Stachow A TI - [Rola of tryptophan metabolism in tha pathogenesis of systemic scleroderma and pseudoselerodermie condtttonal LA - Pol MH - Adolescence J Adult S Agad > Child > Child, Praichool MH - Comparative Study ; Human ; Infant > Intestinal Absorption MH - Middle Age > Scleroderma, 5ystemie/*ettology MH - Serotonin/metabolism i Tryptamtnes/metabolism MH - Tryptophon/Xmetebolism SO - Przegl Dermatol 1979 Nov-Deei66t6):727-9 35 AU - Staehou A i JablonsKa S ; Sktendzieleuska A TI - 5-Hydroxytryptamine and tryptamine pathways in scleroderma. LA - Eng AB - Levels of 5-hydroxytndoleecetic acid, indoleacetic acid and total indoles were determined in the urine of 23 patients with systemic scleroderma and 7 patients with cutaneous scleroderma, before and after peroral loading with L-tryptophan (0-1 gAg body weight!. Before loading, 5-hydroxyindoleacetic acid levels were normal in nearly all cases of systemic scleroderma as well as of cutaneous scleroderma, however after loading, in nearly one half of cases there was no normal increase of this metabolite. These results suggest impaired transformation of serotonin into 5-hydroxyindoleaeetic acid. A disproportionately high ratio of total indoles to indoleacetic acid suggests the presence of excess of tryptamine. The results of the study may indicate that In scleroderma metabolism of biogenic amines derived from Tryptophan is abnormal, probably as a result of impaired activity of monoamine oxidase. (Si - Adolescence i Adult i Aged ; Female ; Hunan MH - Hydroxyindoleacetic Acid/urtne i Indoleacetic Ac Ids/urine MH - Indoles/urine i Male i Middle Age MH - Scleroderma, Ctreumscribed/*metaboltsm tM - Scleroderma, System!c/atiology/*metabolism ; Serotonln/Smetabollsm iti - Tryptamlnes/emetabolism MH - Tryptophan/edministrati on A dosage/metabolism SO - Br J Dermatol 1977 Aug}97()*147-54 35 AU - Stucbiitsin AA ( Delektorski't W ,* Nikitina tM i Bragina EE TX - (Tubuloreticular structu-es in endothelial cells in focal selarodermal IA - Bus Ml - Child i Endoplasmic Ratlculum/eultrastructwe MH - Endothelfum/eultrastructure t English Abstract t Hunan Ml - Mierotubules/eultrastrueture Ml - Scleroderma, Systemie/etiology/epatholcgy ; Skin/ultrastrueture tr- SO - Vestn Dermatol Venarol 1977 Jui!(6 > 3-4 w i ucc 065056 00019235 SCLERODERMA PAGE 11 1 1 37 All - Tomll M > Nagahama H i Mori I > Homma M ! Tamat S i Hosoda Y TI - tUpper abdominal pain, scleroderma of bothaldas of thoflngor* and Tha beck of tha hand (gastric rad1ography)--sch1zophrenia: (stomach cancer and sclarodarma>1 LA - Jpn MH - Adult ; Casa Report i Female > Human > Schfzophrenla/compllcations MH - Scleroderma. Systemlc/etlology/apathology MH - Stomach Neoplaimi/complt ca11 ons/"pathology SO - Nippon Rinsho 1977 Fall;35 Suppl 2:3029-5. 3366-7 36 AU - Van Vloten NA > Scheffer E i Oooren LJ TI - Localized scleroderma-1IKe lesions after bone marrow transplantation in man. A chronic graft versus host reaction. LA - Eng AB - Localized scleroderma-like skin lesions which developed In two children, from 6 to 10 months after successful bone marrow transplantation for aplastic anaemia, showed hlstopathologlcal features resembling those of scleroderma. This finding, like the animal models described In the literature, provides additional support for the auto-immune nature of scleroderma. MH - Anemia. Aplastlc/therapy . Bone Marrow/etransplantatfon MH - Case Report i Child i "Graft vs Host Reaction > Human I Immunity MH - Male Scleroderma. Circumscr1bed/*et1ology/1mmunology/pathology MH - Transplantation. Homologous i Bone Marrow/"cytology SO - Br J Dermatol 1977 Apr;96(9>:337-41 3 3 3 3 3 3 3 * END OF OFFLINE PRINT 3 4 ucc 065057