Document omEwGrzq59Zd892q0oKZywo9w

Monsanto INDUSTRIAL CHEMICALS CO. FROM (NAME ft LOCATION f l_P~Mlenrp. - T7F OATE : February 28, 1975 . BIOACCUMULATION OF AROCLOR PRODUCTS REFERENCE. : . TO : W. B. Papageorge B2SK R. E. Keller - TIB ft. H. Munch - TIB W. R. Richard - T3A E. S. Tucker - R3B D. Wood - B2SC Results of a feeding study reported by the EPA Chamblee Toxicology Laboratory in the appended publication suggest that Aroclor 1016 may bioaccumulate to a greater extent than Aroclor 1242. Since Monsanto's purpose for introducing Aroclor 1016 was to provide a more environ mentally acceptable product, this study is detrimental to our case. However, some of our recent unpublished work shows that at more realistic feeding levels, lower residues are found in rats fed Aroclor 1016 than in rats fed Aroclor 1242. I believe we should publish this work as quickly as possible to counteract the potential adverse affects of the EPA study. A brief comparison of the two studies is shown in the following table: EPA Study Monsanto Study Duration of Test A. Feeding B. Recovery 10 Months 6 Months 30 Days 75 Days Feeding Level (ppm) 100 5 and 25 Lipid Residue (ppm) A. 30 Days B. Maximum A--1016 103 236 A-1242 85 143 A--1016 23 23 A-1242 37 37 If we decide to publish these data, several other candidate dielectric fluids were also included in this study. Should we publish results for any of the following materials? Monoch1orobipheny1 MCS 1043 MGS 1238 MCS 1302 MCS 1475 MCS 1489 MCS 1623 MCS 1633 P. Mieure DSW 342352 db .* -1 A*.i STLCOPCB4083839