Document om3DN7a1M2a8pNXK5rD0JQJG7

THE TRUDEAU FOUNDATION FOR THE CLINICAL AND EXPERIMENTAL STUDY OF PULMONARY DISEASE AT SARANAC LAKE. N.T. THE SARANAC LABORATORY THE TRUDEAU FOUNDATION THE TRUOEAU SCHOOL AT truocau. H r THE DEPARTMENT OF PHYSIOLOGY THE DEPARTMENT OF BIOCHEMISTRY THE DEPARTMENT OP RADIOLOGY THE TRUOEAU LABORATORY fcTouber 16, 1943 Mr. D. JL Bov** Ow Illinois 01*** Coapaay Tolsdo 1, Ohio D*tr Mr. Bowest B1m*4 you Kill flad three eoples of a r*pert on the r**ult* of aalaal rprl--1> vlth Eaylo dust. A* 1* ear sustoa, a* kn ramarlsed briefly mterlol previously presented, In terim report data* Oeteber 30, 1947, ud kn given detailed die- ul aly of euheegueot Aovolepnents. Rm all enperlneats Mao* kD eonpleted, v* aspect to ynpan a fla*I report **<*> will la. elado details of eoeh phase *o that all data will b* available la on# plan*, femro, the anparlaostal itadjr of tho offooto of labeled laylo dost on 0**001 oalafootod aalaal* la aov flalahed *ad enoolntlrai* espressed an that eahjeet oro flaol rather thaa tentative. Ia th* report lsowod om joar ago, uhleh dooorlho* to finding* la aalaal* that labeled laylo dust for parted* ap to 30 aeoths,' tho follovlac toatatlT* conclusion a* aodoi *Za eoaeequeneo of tho eocporiaoatal atadlo* vlth golaoa pics to dot oral ao tho brtolegieol activity of bylo, it aay ho tentatively ooaoladod that laylo alaao fails to predao* significant pulaoaary damage h*a la beled late th* laag.* Bering th* 30 to 34 aanths ported, hovovor, doflalte ladle*tion ef tissue reaction appeared la the 1tag ef aalaal^ Inhaling Kayle duet aad thareforo, Z xogre4 to wy, aor tentative enaolueien fwtk above out h* al tered. la all anlaals *a*rlf&**d after aor* thaa 30 scathe of exposure to Keyle dash aaadstakahls eviAane* of ssbostools has developed, shoving that laylo cm fhalatlna Is eopahl* of producing aahostesls aad oust b* recorded aa a patmtloTTy hemrrtewe aaterlal. It ahoald be acted that alaao aeither ailloosls Mr tho dlffueo pulaoaary flkroda caused by lahaled diateuae-ous earth aae nheeived, th* quarts aad dlatoaaeooaa earth eriapnaeote ef the dust apparently do aot prodaoo tholr tyylkl losieoo. Ia ardor to proeoat aero lafamatioa oa tho subject asboatoais, eertala rrldenee derived frea ear esperlaeatal verb vlth asbeetoe dust has been dieoaseod. is theso findings hare aot jot boon releasod for publloetlon, I re quest that, ehllo uelag than os required la femulating a safety program, yon regard thaa as eoafldoatlal. OTIS HISTORICAL ARCHIVES NATIONAL MUSEUM OF HEALTH AND MEDICINE. ARMED FORCES INSTITUTE OF PATHOLOGY ^ .<-^jVPEtXftlHNITBIIFTFS^ IP , v .vr*-.** . GIlS mSIGRGAl An'-ni.c; ;9a'iiGnal muSEiJM OF health a,ho mEO. ARAVED FORCES INSTITUTE Of PATHOLOGY THE TRUDEAU FOUNDATION FOR THE CLINICAL AND EXPERIMENTAL STUDY OF PULMONARY DISEASE AT SAftAMAC LAICC. N.Y. THE SARANAC LABORATORY THE TRUOEAU FOUNDATION THE TRUOEAU SCHOOL Pag* 2. Mr. 0. E. Bov** Qi** Comaanr AT TMUOCAU. S . T THE DEPARTMENT OF PHYSIOLOGY THE DEPARTMENT OP BIOCHEMISTRY THE DEPARTMENT OP RAOIOLOGY THE TRUOEAU LABORATORY Bovbor 16. 1948 The b*v series of experiments with r*sp*et to the influence of Laylo on tuberculous Infection ax* veil under way and are pro gressing setisfaetorily. It is, of sours*, too eerly to expeet significant results on taleh to bes* ereo tentative ecmelasions. At this tins any I review briefly th* fiannninl arrangaent for ecnduetiag th* investigation with layloT Th# r*s**r*h program up to talj year was sarrisd on undsr a sontraet, initiated in 1945, by vaicn th* *zp*riannt* would b* subsidised with a grant of $5,000. per year. As pointed out in ny letter of Mareh 3, 1944, the eontract terminated officially oa February 15, 1944, but the investigation voald bo continued without charge until June because the original oxporinaats wore started late. Since o eneck was received vaicn took ear* of the subsidy up to loveaber 15, 1947, there ia duo on the old oaatract th* h of |1,250. for the final quarter of the contract (fra levember 15, 1947 to February 15, 1944). V* have delayed sending an invoice for Lie final quarter mtil all work could bo finished and a final report submitted. Following th* termination of the experiment in Juno, it has required several months to do the histological work, study tas tissue sections, collate th* data end prepare the report which aeccmpanlee this letter. Vo are VacInning in toe report a br.ef review of the new experi ments in which the effect of inhaled Kaylo dost am tuborealaus in fection is being studied. Tour purchase ardsrAS-170 authorising this experiment at $5,400. for on* year ia dated February 3, 1944, bat owing to a shortage of anlmsls andpther unavoidable delays the actual experi mental work did met- pt radar way until May. lease we bans seaaladad that flwHkLdmt fir this mew jmeetM hah be kkd BaBBijh. 1944. tarBRka iBTtsii ia ay letter sT'Brsk 3, I suggested n tarn- jmer easkHBM far year, lour latter at Bureb 31 acknowledged this tat fall t# esoflm the extra aaonat of $2,000. involved, lever- theleas, v* have proceeded at the old rate and are endeavoring to absorb the increased cost fra oar Foundation reserve. In a few days ear accounting department will forward a statement of the payments now due in support of the research program, as follovss Qr-i ^i n. l exoerl meat, begun February 1$, 1945, at rate of $5,000. arAualiy For final quarter (Moveuber 15, 1947 to February 15, 1944) $1,25C. Bev .rFr^^| begun May 1, 1944, at rate of 45,000. annually For first quarter (May 1, 1948 to August 1, 1948) For second quarter (August 1, 1948 to Bovsaber 1, 1948) 11,250. 11.250. 13,750. THE TRUDEAU FOUNDATION FOR THE CLINICAL AND EXPERIMENTAL STUDY OF PULMONARY DISEASE AT SARANAC LARS. N.T THE SARANAC LABORATORY THE TRUOCAU FOUNDATION THE TRUOsEet^,n Mr. 0. K. Bowes Ovens- Glsae Reaper AT TRUOCAU. N.T. THE DEPARTMENT OF PHYSIOLOGY THE DEPARTMENT OF BIOCHEMISTRY THE DEPARTMENT OP RADIOLOGY THE TRUOEAU LABORATORY 16. 19A* I realise that our findings regarding laylo are less fsTombl* tbaa anticipated* Severer, since Kayio is capable of producing a bestosis, It is bettor to discover it now in sal--Is ratbar than later la industrial workers. Sms tbo ecapany, being forewarned, will be la s better position to institute adequate control nee cures for safeguardij* exposed employees aad protecting its own interests* Sincerely yours. UTiLB Mce. (3) Arthur J. forvald, M.D. Director