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: <r 3M General Offices. 3LMpaCenteree,IA2-/50F CASI Cg 0p. BEHP-B0-303 August 9, 2004 VIA MESSENGER Document Processing Center (7407M) EPA East -- Room 6428 Attention: Section 8(e) Docket T it RE m32 IEEE VUO1fR2af.0ib0ceEPionefvnningrPsooyolnllmnvueatnniCtioaan3lAP0rPveo3evten8snustetiosonn.aAWng-dnTeoxsics Contaiinn NNo Re: TPeSlCuAorSsecotciaonne8s(s)loSunptpeleDmoecnkteatlNNoost.icSeEHonO-1180:374 OL DearSirand Madam: ---- ST suulbfmoinse yslioflnusoa trihdee(PAOgSeFn)c-yb,as3eMd hcaosmpporuonvdisd.ed POSF-based compounds were dts and other mformaton on included he metab oilnoi3crM'ss pathwaysof the POSF-based compounds that 3M no longer produces for commercial sale.! As EPA has recognized based on these submissions, perfluorooctanesulfonate (PFOS) is the "ultimate degradation product" under certain conditions for manyofthe POSF-derived CSeEeO.SE)PA(1O1P5PT45DomackleteNDooseSIEHmQeAIs.7r4aAbmorpeiotn snyd Boo3Ts0oin1noofebtohyIlsFOSE FrEi nroEnELTaveon ohaDSTSaPL ORy 15% Rrre aPet Comet a Hom ls OSv}erTeno oAa nRSop m0S The Ses rp Pt ompey erso0g 115323 WL % Suma censor) a csuhbesmtiacnacless."wilIln addedgirtaidoen,toa nPuFmObSeruonfdeprucbelritsahiendcosnoduirtcieosnsa.lso report that POSF and its derivative "The two enclosed studies add to thisbodyofknowledge and are briefly described below: + dwdaispaatdemi(nTi-s7t2e1r1e)d MveiataobroalligtaevIadgeenttiofitcwaotiomnaline Raantds.twIon tfheimsaslteudSyp,raagsuiengDleawfliveeymrgat/s.kgTdhoese pfeorlfllouwoirnogofcltuaonreoscuhlefmoincaamlisdwee(rFeOSquAa)n,tipfeirefdliunortohoecltiavneresaunldfosnearmuimd:o aPcFeOtaSt,e (FOSAA or pMeSr5f6l)u,orNo-omcettahnyesluplefrofnlaumoirdoooectthaanneoslul(fNo-nMaemFiOdoSEa)ce.tatTeh(eMs5e7q0u)a,niainfdicaNt-imoenthdaytla-indicate that csucmruulmateixvceeeadmeodunthtescoufmPulFaOtSi,veFaOmSoAu,ntMs55o6f,thMes5e7m0onanodmeNr-sMperFesOeSntEiinntthheedroastel.ivTerheasned draattatosuNp-pMoretFtOhSeEcoinncltuhesiloinvetrhaatndthtehaatdmfiunritshetrermeedtaabdioplaitsempooclcyumrerredwatosMm7et0a,boMliSzSe6d,by the FsiOnSglAe,oraanlddPosFeO,Sb.utTahedsefeidniattiavesucgognecsltustihaotntihnetahdiispraetgearpdolcyamnenortwbaesdmreatwabnoblaiszeedd oafnletrhease data alone. + pCeormlpuaorraotoicvteanMeosluelcfuolnaarmBiidooleotghyoanfoPle(rNf-lEuotrFoOoScEt,anTe-s6u3l16f)o,natNe-E(tPhFyOlS, T-6295), N-ethy p(eFrOfSlAuAo,rogT-c7t07a1n).esulafnodnlaomridPeer(fNl-uEotrFoOoScAt,aneTs-6u8l6f8o).namPiedrefl(uFoSrAo,octTa-n7e1s3u2)lfoinnaRmaitdsoaancedtate GpoutiennteiaalPifgosr pfeorllooxwiisnogmOerparlolDiofseirnagt.ionTihneatpsurapnodseogufitnheiaspsigtsudayftwearsdotsoienvgalwuiatthePtFhOeS, NEgutiFnOeSaEp,igFsOrSeAcAiv,eadnodraFlOgSaAv.ageAdduolstesmaolfevaehnidclfeemcaonlteroSlpr(a2g%ueTwDeaewnl,ey80r)a,ts40anmdg/Hkagrl/edn( sPaFcOriSf,iceetohnerth4e0foifrth60damy.g/kMga/ldeNS-pErtaFgOuSeE-D,aowrl4e0y rmagt/skrge/cdeiNv-edE(orFaOlSgAavfaogrefdouorsedsayosfwviethihcle * PReegr,lu1o1r0o0a7l,ky1l0S1ul0o(nMaatrs.; 1S1i,gn2i0f0i2c)antPeNreflwuoUrsoeoReutlyleS;ulFifnoanlaeRsu;lePraonpdosPerdopSoisgneidfiScuapnptlNemeewntUasleRuRluee,,6675.Fed. Fed Reg. 62319, 62325 (Oct. 1, 2000), * EPrao,duScetirounmEPmeprfllouoyreoeocs4i1,a:n9te SJuOlEfoMn(aSeepatn.d1H9e9p9a)tiEcpainddemLiiopliodgCilcinAiscsaelsCshmeemnitsotfryWoTersktesrinSelruuomrochemical PExearmfiunoartioooncsa,ne1s0u.f1o0n9a7e/0(1P.RJOOSM)00a0n0d5P2e9r5f3uo$r9o2o7c1t.a1n0o;teH(uPmFaOnA)DCooonrcenLtirvaetriaonnds SanedrMnedCiocnaclenStruarticoinls aofe TPeecshfnuoolooogcyt;anPreesnuaftoalnaWtienadnodwOotfheSrusPcerefpliuboriolcyhoemfiPceaflis,voVroo.ocxt,anNeoSuxlxfoEnnavtier-oInnmduecnetdalNeSocniaetnacle aMnodrtality ainPtehreflSuporraogoutea-nDcaswullfepyhRonty,lBFilrutohrDiedfeeMcatnsuRfeascetaurrcihng(PFaarctilBi)tyGSO:c4c6u5p-.47E1nv(i2r00o3n)M;eMdort2a0l03i.ty o6f0E:m7p2l2-o2y5e;es of PDoenrofrlso,ro1o11c:ta1n6csEunfvoiartonemaenndtaOlthHeeralFhluPoerroscpheecmtiicvaelss(Dnech.e2S00e3r)u;moSefrAommeCroinccaenntRreatdiCornossosfAdult Blood PCehcefmlousopthooecrtean5e4su2l0f0n4a)te1a5n9d9-O1t6h1e1r;FBliuootraoncshfeomrimcaatlioinnoafnNE-dEehrylly.NP.op(u2l-ation from Seat, Washingion, yRadtioanndyeHtuhmyapneCoyrtooocchtvaomneesalPfA5o0n.amCihdeembRyesRTaoxLiicvoelr 1M7i:c7r6o7s-o7m5es(,JuCsy,to2s0o0l0,.and Sicandby Expressed 2002 em ncon control (propylene glycol), 160 mg/kg/d FOSAA, or 40 mg/kg/d FOSA for four days with sacrifice on the fifth day. PFOS, N-EtFOSE, FOSA and FOSAA all caused indications of peroxisome proliferation in rats, but not in guinea pigs*. Because the observed peroxisome proliferation could be due to parent compound, metabolites, or|both, the study also treated animals, including those instances in which group controls had no measurable background PFOS or FOSA. Because FOSA wouldnotbeexpected to form as a `metabolite of PFOS based on the known chemistryof PFOS and the fact that there were several instancesofhigh background levels of FOSA in controls, the potential for confirm that FOSA is or is not a metaboliteof PFOS. Regardlessoforigin, FOSA was further metabolized to by formation ofthe glucuronide conjugate (FOSA N-glucuronide). `minor metabolites, including N-2-hydroxyethyl-perfluorooctanesulfonamide, N-EtFOSAA, ato re Please contact Andrew Seacat (651-575-3161) if you have any technical questions or if we can provide additional information. For any other assistance, please do not hesitate to contact the Sincerely, PSKtouIirnaet, Efvairdon.men1t%)Hostad Sty Operations TA p doneMBeeiEOTpoollme p si "0003