Document oeYK1NLKMvj0z6JBRRrna3EzR

EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. AR 286 - R7TR3 Report Title PATHOLOGY PEER REVIEW AND PATHOLOOGFYMWAOMRMKAIRNYGGGLRAONUDPS REVIEW FROM AICN HRRAOTNSIWCIFTHEEPDFIONAG STUDY" PWG REPORT . Data Requirement NA . sey F. HAaurtdhiotry, O.M. JuneD1a7t,e2008 Pertorming Laboratory Experimental Pathology Laboratories, Inc. P.O. Box 12766 Research Triangle Park, NC 27709 Sponsor HeaDluthPoanntdHEansvkierllonLmaebnotraaltoSrcyiefnorces . 109P0.0E.lkBtooxn 50Road Newark, DE 19714 EPL ProPjreocjtecNto.ID120-060 VOLUME 1 OF 1 PAGE 10F 74 1 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. T PATPHAOTLHOOGLYOWGOYRPKEIENRGRGERVOIUEPW ARNEDVIEW FROM OAFCMHAROMNMIACRYFEGELDAINNDGSSTUDY INRATS WITH PFOA CERTIFICATION OF GOOD LABORATORY PRACTICES TLhaibsorPaattohroylPorgayctWiocrekSitnagnGdarrodusp (R4e0vCiFeRw,(PPaWrGt)16d0o)esdonontotcoanpsptliytuttoe tahissturdeyp.ort.TheHroewfeorvee,r,Goalold appropriate documentation of the review process has been maintained. * Signature: AuthJeorkyr F. Hardisty ate: 200% 2 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. . PWG PARTICIPANTS: : ES F. frosty. D.V.M! Diplomate ACVP (Chairperson) . GF(RAReBCvR.ieIwEPiaLntLghEPaA.thWolIoLgLiSstON, B.V.M.S, MRCVS \ . ": W. RAY son D.V.M., Ph.D. Diplomate ACVP (Consulting Pathologist) Cds me fo (DECiRopNnlsoEumSiatTtienEgA.CPMaVtCPhCo,OloANgBNisTEtL) L, D.V.M., M.S. , 3 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. PATPHAOTLHOOGLYOWGOYRPKEIENRGRGERVOIUEPW ARNEVDIEW FROM OAFCMHARMONMIACRYFEGEDLIANNGD,SSTUDY IN RATS WITH PFOA TABLE OF CONTENTS TITLE PAGE CERTIFICATION OF GOOD LABORATORY PRACTICES PWG PARTICIPANTS' PAGE TABLE OF CONTENTS NARRATIVE APPENDIX A PWG Consensus Each Group Diagnoses for Individual Animals Reviewed in APPENDIX B Statistical Analyses of Mammary Tumors in Rats Fed PFOA APPENDIX C Curriculum Vitae T Page Co 2 3 4 5 1" 19 . 2 4 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. . PATPHAOTLHOOGLYOWGOYRPKEIENRGRGERVOIUEPW ARNEVDIEW FROMOAFCMHARMOMNAICRYFEGELDAINNDGSSTUDY IN RATS WITH PFOA EPL PROJECT NO. 126-060 NARRATIVE SUMMARY INTRODUCTION Hematoxylin and eosin stained and trichrome stained microscopic sides of . mammary received f gland rom Du from Pont female r Haskell ats used in Laboratory ac for hronic feeding study in rats Health and Environmental with PFOA were Sciences, Newark , rt. . Delaware by Experimental North Carolina. The study Pathology Laboratories, Inc. (EPL), Research was conducted by the 3M Corporation and the Triangle Park, issues from the study had previously been examined and the results reported by Dr. Robert Geil the Study Pathologist (SP) for the 3M Corporation. A summary of the group design according to the protocol orthe study is summarized in Table 1 below: . Table 1. iEnxFpeermiamleentSaplraDegsuieg-nDafworleayCRhartosniwcitFheePdFiOngAStudy Two T+] Group No. _ TDesitetMaartyerLiealve(lpopfm) Number of Female Rats . Saicnrteirfiimce TSeacrrmiifniacle cow | 5 | eo | Or. Gabrielle Willson, the Reviewing Pathologist, reexamined all sections of mammary gland from all female rats in all groups, al previously reported mammary neoplasms and all previously reported subcutaneous neoplasms. Prior to the reexamination of the sides, the necropsy records were compared to the reported microscopic findings to ensure that all grossly described mammary and subcutaneous masses were sectioned and 5 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. T , `examined microscopically. The purposeof the peer review was to validate the accuracy and consistency of the initial histopathologic examination and to identify the issues that needed 0 be addressed during the review. The preliminary review of the data indicated that al masses were sectioned and examined microscopically Following the reexamination of the histopathology findings of all sections of the mammary gland by the Reviewing Pathologist, a Pathology Working Group (PWG) was' convened for the purpose of providing a consensus diagnosis for all neoplastic lesions involving the mammary gland which were diagnosed either by the Study Pathologist or the Reviewing Pathologist. The PWG members consisted of the Reviewing Pathologist, Dr. Wilson, and the two consultant board-certified veterinary pathologists with extensive experience in the microscopic evaluation and interpretation of lesions observed in chronic toxicity and oncogenicty bioassay studies conducted in rodents. The original Study Pathologist was not available for the PWG meeting. The PWG's task was to provide a consensus diagnosis for eachof the mammary gland neoplasms reported by either the Study or Reviewing Pathologist and to determine the toxicologic significanceof the. incidence of mammary gland neoplasms present in the female rats treated with PFOA in the diet. Conduct of the Reviewing Pathologists Examination : The mammary gland and all subcutaneous masses were evaluated fof histopathologic changes during the Reviewing Pathologists examination conducted by Dr. Willson. Although ail microscopic findings in the mammary gland were reviewed, particular emphasis was given to neoplastic lesions. All sides containing sections of mammary tissue witha primary neoplasm of the mammary gland diagnosed by either the Study or Reviewing Pathologist were organized for the PWG review. 6 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. . Conduct ofthe Pathology Working Group Review The Pathology Working Group was chaired by Dr. Jerry F. Hardisty, Experimental Pathology Laboratories, Inc. (EPL), who organized and presented the material to the panel of three pathologists. Curricula vitae for the PWG Chairperson and each of the PWG participants are present in Appendix C. The PWG review was performed on May 19, 2005, at Experimental Pathology Laboratories in the Research Triangle Park, North Carolina. Individuals attending or participating in the PWG review are listed below: Or. Jerry F. Hardisty, Diplomate, A.C.V.P. (PWG Chairman) DFr.RCGabPraitehlle Willson, (Reviewing Pathologist) Loe DrD.ipWl.omaRtaey, BArCoVw.nP. (PWG Participant) ' : . ODr.ipElEo.matMec,CAoCn.nVe.lPl. (PWG Participant) Or. Steven R. Frame Diplomate, ACVP Mr. Gerald Kennedy (Observer) (Observer) The PWG examined coded slides without knowledgeoftreatment group. Each participant recorded his/her diagnoses and comments on worksheets which were prepared by the PWG Chairperson. The PWG examined the mammary gland only for neoplastic lesions and did not consider other lesions which may have also been present. Each lesion was discussed by the group, reexamined if necessary, and the final opinions were recorded on the Chairperson's worksheets. The consensus diagnoses of the PWG were reached when at least two of the three + PWG participants were in agreement During the PWG review, the nomenclature and diagnostic criteria recommended by the Society of Toxicological Pathologists was used by the PWG to classify the proliferative lesions (Mann, et. al, 1996). A summary of the diagnostic criteria and nomenclature used by the PWG participants for proliferative lesions of the mammary gland of rats is presented below: 7 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. : T Nomenclature and Diagnostic Criteria for Proliferative Lesions of the Mammary Gland in Rats LOBULAR HYPERPLASIA : * Dilatationofducts or ductules usually present Evidence of epithelial or glandular prolferation. . * May contain mild cellular pleomorphism and mitotic activity. FIBROADENOMA Lt Composed of glandular epithelium and fibrous connective issue, . Epithelium is generally single layered and uniform and may contain lipid vacuoles. * Comective tissue distributed within and between lobules ranges from welldifferentiated to dense hyalinized collagen with few interspersed fibrocytes Epithelium often forms ductules, alveoli or small cysts. Focal areas of atypia andlor cellular pleomorphism may be present, Mast cells may be frequent ADENOMA Discrete nonencapsulated mass consists of proliferating alveolar structures in clusters separated by scanty connective tissue septa. . Aslivnegollei nhuacvleeoalussi;ngelpeitlhaeyleiruomfolfotwencuvbaociudolaaltteod.columnar e.pithelium with small nuclei and a Alveolar lumina may be empty or filed with minimal secretion (tubular pattern) or may be widely distended by proteinaceous secretion (secretory pattern). * Luminal surface of epithelium generally round, may be smooth or serrated. Focal areas of atypia and/or pleomorphism may be present Papillary projections of epithelium may occur, either protruding into dilated ductal lumina (papillary pattern) or into cystic spaces which may be simple or multioculated (cystic papillary pattern) ADENOCARCINOMA * May be noninvasive or invasive. 8 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. May have distant metastases. ' ' Neoplastic epithelial cells from 1-4 or more layers thick. Uniform epithelial cells basophilic to eosinophilic with round to oval centrally Chromatin clumped, single small nucleolus. Numerous mitotic figures. located nuclei CMluoltsiepllye pbarcaknecdh,inggenpearpaillllyaecmpolvye,retdubbuylacrubstoriudcatlutroescwohliucmhnamraeypibteherloiuunmd(poarpiellloanrygaptaettdern). (tubular patter) * Neoplastic epithelial prolferation in a sold sheet with the formation of secondary lumina (cribriform pattern). tDuimsoterncdeeldlsd(ucctoumleedsolipnatetderbny),a multiayered epithelium surrounding a central core of necrotic + ! : . ADENOCARCINOMA ARISING IN FIBROADENOMA * Adenocarcinomatous change within a fibroadenoma. Histologic pattern of fibroadenoma component variable. Typical histologic appearance of adenocarcinoma present After the PWG completed the siide review and the diagnoses were recorded by the PWG Chairperson, the sides were decoded by treatment group. PWG consensus diagnoses for individual animals reviewed in each group are presented in Appendix A. A summary Table 2. of the incidence of neoplasms in the mammary gland of female rats is tabulated in ` 9 EPL EXPERIMENTAL PATHOLOGY LAB! RATORIES, INC. " . Table 2. ChrIonnciicdeFneceedoifngMaSmtumdayriyn FGleamnadleNeSoppralgausem-sDianwFleeymaRlaetsRawtitsh PFOA: [T Teeleerw|alecT oemem|] cuepes]] LsMAMMARY GLAND - Number |& | : Fibroadenoma (%) 8 13 16 19 [E oesR a TaTanl ialo a8A]e LEE ew AL a er BR ERNe (Re TD | Ee No.of Animals with Both Benignand | 2 |] 7 [=]0] Sy LR we MEIC FR REEE No.of Animals with Mammary Tumors HEE =Re 29 | =;[=| 2 ** Two Group 5 female rats had fibroadenoma present in the interim sacrifice group. DISCUSSION AND CONCLUSION The results of the PWG Review generally supported the Reviewing Pathologist's findings. The primary difference between the original reported findings and the PWG results involved changes in the mammary gland that were initially reported as lobular hyperplasia 0 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. ras mst. . and malignant neoplasms, the majorityof the other neoplasms reported by the Study Pathologist were confirmed during the PWG review of mammary gland neoplasms in female Although the incidence of neoplasms varied among the control and treatedgroups, there were no statistically-significant differences when evaluated using the Fisher's Exact Test for pairwise comparison for fibroadenoma, adenocarcinoma, total benign neoplasms or total malignant neoplasms. The PWG noted that although it is not recommended that benign and malignant neoplasms be combined since there was no histologic evidence of tumor progression from benign to malignant (McConnell, 1986). However, even if combined inthis study, there was no only statistically significant significant difference difference between control (<0.01) involved a negative and treated groups. The pairwise comparison in the . incidence Statistical of an adenocar alyses of cinoma mamma in ry Group 6 (30 PPM) compared to Group tumors in rat fed PFOA conducted by 5 (300 ppm). Dr. David W. Gaylor are presented in Appendix B. There was no increase in tumor multiplicity or incidence with dose between control and treated groups. The morphologic appearance of the neoplasms present in treated groups was similar to those observed in the control groups indicating that treatment did not affect the phenotoyfpthee neoplasms in the study. The incidence of mammary gland neoplasms observed in this study is similar to historical control data for mammary gland neoplasms in untreated Crl:CD female Sprague-Dawley Rats in 104 week studies in the open literature (Inveresk Research, 2002; Giknis and Clifford, 2001; Giknis and Clifford, 2004; Chandra, et al., 1992; McMartin, et al., 1992; Stevens, et al, + 1994; and Sykes G, 1987) presented in Table 3. Table'3. Historical Control Data In Untreated Crl:CDFemale Sprague-Dawley Rats In 104 Week Studies Lo : ` Avsereagee i(Rnange) | mogssn |sein mess oom " EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. " ADENOMA FIBROADENOMA [ADENOCARCINOMA REFERENCE T 354% (uA 18.96% (NAN sso- ) Cthoamndra, etal. 85% 20-11.4%) | 31.3% 200-43.3%) | 166% (67-300%) | M15a0 i ON, eral, 154.07 33% (36.48) 17% 19) 1S9t9e4v,enAst,raIzTi.neeral; S1t99e4v.enPs,roJpTa.zionteal. S16t9e4v,enSsi,mJaTs,itneal 4% (031 20% (11:57) 6% (318 S1t9e4v,enTse.rJuTi.yeltaasline A=19No%t-aOva1i%ab)le | 374% (242.540%) | 14.1% (65265%) | RSEeynckhoersAdG2,d2169-8e179.1r7US CONCLUSION The PWG concluded that the incidence of mammary gland neoplasms in this study was not affected by chronic dietary administration of PFOA. The morphologic appearance, overall incidence were similar and distribution of the neoplasms observed in treated and .control . groups a FVARDISTY, Sa . CDhiapilormpaetres,onACVP TF eos Date 12 EPL : EXPERIMENTAL PATHOLOGY LABORATORIES, INC. . REFERENCES : DCahwalnedyraraMt,s.RAirlceyh MToGxIicoaln,d6J6:oh4n9s6o-5n02D.E (1992) Spontaneous neoplasms in aged Sprague sGuirkvniivsalMiLnACrain:dCDCii(fSoDr)d CBRB r(a2t0s01f)roCmomcpointlraotliognrooufpss.poCnhtaarnleeosuRsivneeropLlaabsotriactloersiieosns and sGuirkvniivsalMiLnACta:nCdDCli(ffSoDr)d CraBts(f2r0o0m4)coCnotmrpolilgartoiuopns.ofCshpaornletsanReiovuesr Lnaebooprlaatsotriicesl.esions and Inveresk Research (2002) Background Tumour Incidences CD Sprague-Dawley rats. lMSeTasRniIonAnsRPoPCfI,AtBFhoIePom,ramWmaamnsahGirAny,gtgLolonal,inndiD.iLnC.Or,asM,cM15a-r2t.iInnDGNuiadneds fGooroTodxmiaconloDgGic(P1a9t9h6o)loPgryo.liferative . v "combMicCnoinnnelgl nEeEo,pSloalslmesveflodrHeAv,aluSawteinonbeorfgroJdAenatncdarBcoionromgaennesGiAs 283-289. s(t1u9d8i6e)s.GuJiNdCeLl;inVeosl.fo7r6, No. 2, MrHiecslMtaaotrreitdciapnlrodDlaiNtf,earSaatanihdvoetdliaeasgPinSoo,nsstGiiuncnccsooonntnsriodDleErS,aptHriosangusu.He-HTDoaxaiwncldoelSyopgriaacltsPaRftrHhoom(l1oc9ga9yr2c,)iVnoNolge.eon2pi0lc,iatsNymussmtbuadenireds.2, 212225, JfSoutrrenmvaealnmosmfJaTTro,xyiBcrtoeulcmokogerynirgaiennddegseEinCsvBii,nroWSnepmtrezanegtlualeL-TH,DeaaGwliltlhle,sy 4JR3Ha:ta1s3n9ed-xL1pu5oe3smepdertotcIellrtLaGin (t1r9i9a4zi)neHyhperobtihceisdiess. USySkeEsPAGA(d1m9i8n7i)stTrwaot-ivyeeaRrecTooxridci2t2y6/-C1a9r1c7i.nog1e-n6,icity Sudy of Fluorochemical FC-143 in Rats. ` 13 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. . APPENDIX A PWG ConsenRseuvsieDwieadgnionsEeascfhorGIrnoduivpidual Animals 14 T : 55, | [| J| i2 BE [012 el ole| lo L{lIE Eool Elelol 2 olez [el:e $8 Hizgezesizazabanliaet g| E| Emmmleninlannin: SEI inn En 2/82/2128 2(5/5'5|2(8| 5/25/98 58| &|2 ENE hn ee soles gg B(5|8 2 EE HR Ha EE i2 | i4 , 3 < sEEa52 i[[85e,8 | } d AT; I:g: 5 5E8:E8 8S5895E|E, 38 2 51555 EglEel||E | 2zLali|sdilal z[es[55EsEl[aslz allaflse || 1|B god 5/555 = CE82C|E F | S FoE EiE olE Bs5R1r5R /eC5/e5c/s5e 1aia5/eE5Bg/R 5RE(E5nR5E/it 5e eE2/s5/l 5sd e 51e5]gnEd e |s5e[5s(2 3gE z a3H | BSl| E 5[8Do 2 88 (|al5|. |(a8la8f [[a53. || Eilelas ol || BeEe a3 52| [2 42|[8|5\2H8B8EeE/EeEAES| ||oloBSEEdeelEelE2nsglosl:E HIBEEEEET; BEnEs enn D[a5d2s eHle[3s ERenecie EEREEE ReEESRlER EEe RE FfeRedRgeosaeys 518, EEBl|E08I/5E5|ge8E8dE8) 78al2Be BECEeeReERzkCEEnEEuCYsn B8oY5y h8s3hi/E3de8 mf2/ae2ld8 ER nn 528g 2525 |||| |5g | 2lsEols | Ele | Le 2if1 E10EedRE ol aERlEeeERPEEECRBEER [&8| [380(28128182193/89lz213 2125/868/555/558/ 958 T |51a 9) 5/5| 8855/5188555 8[85(8/5 2 Reel dee fans sg Ee i2 . HH 3 g2e Is '> |El Eds 5 sd EE e < Llzell lg BB= FS EBTY g2s2 1(8 E|SBg5oz8leog2zgsieLslzlireg8gel|mgseesllesleeofc2B5ae2nsFlsale5ta8 lF5 n818aal5i5e|q5t5ss 8 15 5i55(5 5ielsls eles 5 515 H Se 5%is | B 3E /81R 815/5E 5R 8 8/e 3/5R 15e (5/d8E E5a8E E/5ss E|8 22siese Eg5et/d 3a8eE (t65ase 51|3E a52/E58se /]sE58es2) F & 1 Eg = 5598 : 5 12282 25(elel, e 7< lol HlERE el SEEEE [1H8H | 5 |RleE aE EEEgecE EeEE E E zE zz: [H BE gee egRE SE83855F (BEEEE] [558 | E EEsEErE EasRsess SER anye BEYEE Bo BREEZE Hl EERE [25] FREESE4 EEE RENEE SEPHIYNE [gE 2eE . 5 | | i28 o| i =. 2| 2 2 ne eel |e] 2] $C | 2p[3dB2Ee3Ed2Ce2Es8Ee8EE e2EEE8dL3 E2M/R2E8s2R|Cn5i/na E 5Rn|a55(E /s58]c8s||5E|55sE ]5|s|f55E|o5|ss5 <3 l2e 5=LE85P23 o2ER%s oof 2 a-3 || zBL] le] | [ee gE2322 SEBSel loin If[ Fg IE E3gEg E gEee E zanng deEseEie nssEaog ignaoeh nneclnaiae nsla sBHll eaEsiEssea goelses = f| EERE gEEtR ieese nes s 3R EenE gS : HT I| ] || hk LE i Ee 2 |5 " | ELH 23 la jefe Ee 2eal || IE) s8a|g i |[g|E rliEeCfE lEdoiE snsgs (Be FRERSEsfssencse aEResE sEeng eBBT ofEeRTEieEReEERR]EE B[sBgoeBdneE 5seTidId$dTie dB2RdzR2cE2id8le8dE2id8iecegEedeeds0hdisd8isdesd:nsdy 4) 38 EH =$335 0/8lalal2 2 Egg | [H5HsEElESesEEsEE/sE5sEE5(E552 82 184 5 nl : 8 EE of |, gf = 8222 [8/s5l/E3/s3z3e/s58g2s2t/et 8 1 gle ] f } 2 EsE8 || Is5 SLE EH IfeBsEeTiezsedes51s 2J 8 BEBE -- EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. APPENDIX B Statistical Analyses of Mammary Tumors in Rts Fed PFOA ! : 19 6/12/05 : . : Statistical Analyses of Mammary Tumors in Rats Fed PFOA David W. Gaylor, Ph.D. Gaylor and Associates, LLC Introduction Female Sprague-Dawley rats were fed PFOA in a chronic bioassay. The incidence of animals with mammary tumors reportedbythe Pathology Working Group are listed in sTuarbvlieva1.l) TashecadlecunloamtiendatboyrtshearNeatthieoneaflfeTcotxivieconluomgbyePrroofgarnaimmaPloslya-t3rpisrkoc(eaddjuursete(dPofrotrier and Bailer, 1989). . Table 1. Incidence ofmammary tumors in female rats fed PFOA. oe . Tumor type ppm 30ppm 300 ppm Adenocarcinoma 9/404 16/434 S414 Fibroadenoma 18/414 22/4117 23/443 Adenoma 1/384 0/385 0/414 Fibroadenom/Adenoma 19/417 22/411 23/443 Adenocarcinoma/ ! Fibroadenoma/Adenoma ~~ 24/429 31/447 25/453 Results Noneofthe statistically stiugnmiofrictaynptessuorrvicvoamlbaidnjautsitoendsodofset-urmeosrpotnyspeestrleinsdtse.d in Table | exhibited No statistically significant survival adjusted pair-wise increases noted. All P-values exceeded 0.10. in tumor incidence compared to controls were References sPuorrtviievra,l-CaJdjaunsdteBdaiqluearn,taAll.reTsepsotnisnegtfeostr.inFcurnedaasemdenctaracliAnpopgle.nicToixtiycouls.in1g2:a 731-737 (1989). 20 EPL : EXPERIMENTAL PATHOLOGY LABORATORIES, INC. APPENDIX C Curricula Vitae , : 21 PA] et e i rr t vr res. : JERRY F. HARDISTY PRESIDENTIVETERINARY PATHOLOGIST EDUCATION: Iowa State University, Pre-Veterinary, 1965-1967 Iowa State University, D.V.M. 1971 Certified by the American Collegeof Veterinary Pathologists, 1976 Adjunct NC SAtsastoeciUnaitveerPsriotfy,es1s9or83at the School of Veterinary Medicine, . PRESENT POSITION AND EXPERIENCE: | . 1998 - Pr:esent. ~ IPnrc.e,siRdeensteaarncdhPTartihaonlgolgeisPta,rkE,xpNeorritmhenCtaarlolPiantahology Laboratories, lRaebsoproantsoiribelseifnorViorvgeirnailalamnadnNaogretmheCnatroalinnda.dirTehceticonomofpaconnytrsaecrtvreessbeoatrhchgopvatehronlmoegnyt and university research and the safety assessment programsofthe pharmaceutical, chemical, and cosmetic industries. . 1994-1998. Vice President, Operations and Pathologist, Experimental Laboratories, Inc., Research Triangle Park, North Carolina Responsible for overall management and direction of pathology research laboratories in North Carolina and Virginia. . 1978-1994. Director and Pathologist, Experimental Pathology Laboratories, Inc., Research Triangle Park, North Carolina RNoerstphonCsairbolleinfaorbtrhaencphroojfecEtPLm.anaRgesepmoennsti,bldeirfeocrtitohneamnidcrtoescchonpiiccalevsaulpueartviiosnioonfof the toxicological studies. Responsible for the National Toxicology Program's Pathology Quality Assessment Program and Operations of the NTP Archives. 1976-1978. Pathologist/Project Manager, Experimental Pathology Laboratories, Inc., Hemdon, Virginia RPreosjpeocntsMiablneagfoerrtohfe amapnroaggreammetnotporfovEiPdLe'sTrCaacrocriJniotgceonweistihsQSuaulpiptoyrtAsLsaubroraantcoeryi.n t10heprNoCvIidCeapractihnoolgoegnyessiusppToersttisnegrvPircoegsrtaom.theTeCcahrnciicnaolgesnupeesrivsisPiroongorfama opfrtohgeram tNiastsiuoensalfrCoamnceexrpeIrnismtietnuttae.l aRneismpaolnssiubsleedfionrathvearmiiectryoosfcotopxiiccoelvoagliucaatlisotnudoifes. 22  Experimental Pathology Laboratories, nc . JERRY F. HARDISTY, D.V.M. Continued : 1P9R7E2S-1E9N7T6 POSITIROeNseAaNrcDhEPXatPhEolRoIgiEsNt,CVEet--eCroinnatriynPuaetdhology Branch, Biomedical Laboratory, Edgewood Arsenal, Maryland PDra.thHoalrodgiys.tyDwuarsinga tprhescteipmteeeheinptehrefoU.rSm.edArgrmoysspraencdepmtiocrrsohsicpoppriocgdriaamginnosVeesteorfinary slapboonrtaatnoreyouasnimdailsse.aseHeanpdrecphaarnegdersepporrotdsudceesdcrbiybienxgpearnidmeinnttaerlprpertoicnegdtuhreesse in experimental resuls. tDeurraitnoggetnhiisctsitmuedihees wpaersfoprrimnecdipaatl ithnevelsatbiograattoorryf.or tThheisrewporrokduccotnisvei,stmeudtoafgerneviics,ing : pLrieivzieoduastetxhpeerliambeonrtataolryp.rotTohceolesxpaenrdimdeenstiaglnidnegsingenweemxppleoryimeedntraelqupirroetdoctohlesg1r0osbse. : , : etexraamtiongaetniesoins.of pHreeginraainntedfebmiaolloegircaatls taencdhnfiectiuasnesstfoorpeervfiodremncteimoefdfemtaaltitnoxgisciity raantsd, . efoxrapmrienneatsaelriaablnloyrsmaelcittiioense.d fetuses for malformations, and to examine fetal skeletons 1671-1872 WAtatletnedriRngeeVedteArrimnayriIanns,itDuitveisoifoRneosfeBairocShensor Research, Dmru.scHualrodsiksetlyesttauldideidsetahseersadofiotghreapGheircmaannd SmhoerpphhoelrodgiDcogl.esiIonnassosfocsieavteiroanlwith Dr. cWaanyinneehRiipsedry,sphleasiinav,esetoisgiantoepdhitlhiec ppaantohsotgeeinteissiasndanudnupnoistseidblaengceonneetailc prerloacteisonssehsipinofan attempt to reduce their incidence through a selective breeding program PRODFipElSoSmaItOe,NAALmeMriEcMaBnECRoSlHleIgPeSo:f Veterinary Pathologists 3 `AACmVerPicSaunbsCpoelclieaglelyofiTnoTxoixciocloolgoygic Pathology SSoocciieettyy ooff TToorxiiccoollooggiyc Pathologists BInrtieirsnhatSioocniaeltAycoafdTeoxmiycoolfoTgoixciPcaotlhoogliocgPisattshology ANmoretrhicCaanroVleitneariSnoacriyetMyeodficTaolxiAcsosloocgiyation CThhaerlSeosciLeoluyiosfDPahviisZ,etDa.V.M. Foundation TThhee SFroactieertnyioyfoGfaAmlpmhaa ZSeitgama Delta ATmheerFircaatnerAnistsyocoifaOtimoengfaor TthaeuASdivgamnacement of Science 23 PA -- JERRY F. HARDISTY, D.V.M. - Continued PROFE`SSStaInOdNarAdLizAedCTSIyVsItTeImESo:f Nomenclature and Diagriostic Criteria (SSNDC), The `Society of Toxicologic Pathologists, 1967-1985. EExxeeccuuttiivvee CCoommmmiitttteeee,CThhaeirSmoacni,etTyhoef TSooxciiceotlyoogficToPxaitchoollooggiicstPsa,th1o9l9o4g-is1ts9,98. 1997-1998. Joint Committee for STPS/ILSI on Intemational Standardization of : Nomenciature Co-Chairman and Diagnostic 1995-Present. Criteria for Toxicologic Pathology, 1994-i 1995, PPrreessiiddeenntt-,ETlehcet,SoTchieetSyocoifeTtoyxiocfoTlooxgiiccolPoagtihoclPoagtihsotlso,g2is0t0s0,-21099091-2000., Lo . PLaosntg PRraesnigdeenPtl,aTnhniengSoCcoimemtyitotfeTeo,xiAcmoelrogiiccanPaCtohlolloeggiestosf,To2x0i0c1o-l2o0g0y2,,2002. * North American Director, International Academy of Toxicologic Pathology, FDA20C0li2n.ical Pharmacology Subcommittee of the Advisory Committee for Pharmaceutical Sciences, FDA Center for Drug Evaluation and Research, 2003. EDITORIAL REVIEW BOARD: International Agency for Research on Cancer (WHO), Classification of Rodent Tumors, Part ll, The Mouse, 1995-2001 EditToroixailcRoleovgiyewBoBaoradrdoffoPrubFluincadtaimoensn,ta1l99a6n-d19A8p8p.lied Toxicology, Soci. ety of EditoorfiPalubRleicvaiteiwonBs,oa1r9d98f-o2r0T0o4x.icological Sciences, So.ciety of Toxicology Board Editorial Review Board for Experimental and Toxicologic Pathology, 2000. PFaUcBtLorIsCpArTeIdiOsNpSosiAnNgDtoPuAroPiEitRhSia:sis in feedlot cattle. Hardisty JF and Dilman RC. The Iowa State University Veterinarian, lowa State University, Ames, lowa, 33(2), 77-81, 1971. RCaesdtulcetbieornryofMfWr.eqIunenPcryocoefehdiipngdsy,spClaansiianeinHmiipltDayrsypldaosgis.a Riser WH, Symposium Hardisty JF and and Workshop, OFA, Columbia, MO. 1972. SGceanleetriac SiEn.f,luCeanscetioefbetrhreymMalWe oanndthReisienrciWdHe.nceInoPfrcoacneiendeinhgisp,dyCsapnliasniea.HiHparDdyissptlyasJiFa, `Symposium and Workshop, OFA, Columbia, MO. 1872. 24  . JERRY F. HARDISTY, D.V.M. - Continued : PUBLICATIONS AND PAPERS = Continued Evaluation of the effects of chemical compounds on the reproductive system of rats. Hardisty JF. Presented at the Biomedical Laboratory Review and Analysis, April 1975. Reproductive studies with quint essence compounds. Hardisty JF, Presented at the Biomedical Laboratory Review and Analysis of Quint Essence, January 1676. Effects of KZ/IP mixture on the reproductive system. Hardisty JF.and Pellerin Ro. Edgewood Arsenal Technical Report, 1976. : Reproductive studies with diisoproplymethylphosphate in rats. Hardisty JF, Pellerin RJ, Biskup RF and Manthei JH. Edgewood Arsenal Technical Report ARCSL TR 77037, | : May 1977. : : QPuaatlhiotlyogayssWuorraknscheoipn,paBtehtohleosgyd.a,HMaDrd.isJtuynJeF,19W7a8.rd JM and Griesemer RA. N.CI-NCTR WMoornkosnhuocpl,eaBretcehlelsldeau,keMmDi,aJiun nFeis1c9h7e8r. 344 rats. Hardisty JF. NCI-NCTR Pathology Quality assurance for pathology in rodent carcinogenesis tests. Ward JM, Goodman EDnGv,irGornimeesnetmaelrPRaAt,hoHlaorgdyisatnydJFT,oxSicchouloeglye,r 2R,L,37S1q-u3i7r8e,RNAov.a-nDdecS.tr1a9n7d8b.erg JD. Journal of Neoplasms and pigmentation of the thyroid gland in F-344 rats exposed to 2,4diaminoanisole sulfate, a hair dye component. Ward JM, Stinson, SF, Hardisty JF, ACporciklre1l9l79B.Y and Hayden DW. Journal of the National Cancer Institute, Vol. 62, No. 4, dRiebnraolmocparrocpiynlo)gepnhiocsapnhadtnee]phinroFt-o3x4i4c reaftfsecatnsdofBtEhCe3fFl1ammeicree.taRrdeaznntikTRGI,S(W(a2,r3d- JM, : Hardisty JF and Russfield A. Journal of the National Cancer Institute, Vol. 63, No. 1, July 1979. : mCoircrreolsactoipoincablelytwienecnargcrionsosgeonbesseirsvabtiiooansssoafystuimnorratss.anKdulnweiocphlBaAs,msHadridaigstnyosJeFd, Gilmore GE and Ward JM. Journal of Environmental Pathology and Toxicology, 3, 281-287, December 1979. cEavracliunatoigoenneosfisprtoecsetdinugrepsrosgurgagm.estHeadrdfiosrtyreJdFu,cWinagrtdheJMp,atDhooulgolgayswJorFkalnoaddFienaras TR. Journal of Environmental Pathology and Toxicology, 3, 167-176, December 1975. 25 BEPL' corns ronson --_ JERRY F. HARDISTY, D.V.M. - Continued CPaUnBcLeIrCiAnTduIcOtiNoSn AND PAPERS ~ Continued following single and multiple exposures'to a constant amount of vinyl achnidorHiadredimsotnyomJFe.r.PreHseheinrteRdMf,orMtchNeacmoanrfeareBnPc,eMtcoLraeu-gehviailnuaJt,eWtihleliTgoaxniDcAol,ogByioefrbVoiwneyrl G Chloride Monomer, Polyvinyl Chioride and Structural atthe National Institute of Health, Bethesda, MD. Analogues on March 20-21, 1980,: * Cancer induction following single and multiple exposures to a constant amount of vinyl chloride monomer. Hehir RM, McNamara BP, McLaughin J. Willigan DA, Bierbower G and Hardisty JF. Environmental Health Perspectives, 41, 63-72, October 1981. , CKoarrncrieniocghenMe.siTshebiTooaxsiscoalyogoifs2t,,6V-Xoylli3,diNnoe. in1,raMtas.rcHhard1i3s8t3y. JF, Montgomery CA and Chronic toxicity and oncogenicity bioassay of inhaled toluene in Fischer 344 rats. Gibson JE and Hardisty JF. Fundamental and Applied Toxicology, 3: 315-319, 1983. Quality assurance in pathology for rodent carcinogenicity tests, by GA Boorman, CA Montgomery, JF Hardisty, SL Eustis, MJ Wolfe and EE McConnell In: Handbook of CNaoryceisnoPguebnlTiecstaitnig,o1n(9sH85,M.ilman and E Weisberger, eds), pp. 345-357. New Jersey: `ESCysatnemdicSeelfgfercatdsefMoJl.lowPirnegsiennhtaeldataitonthoef fog oil North obscurant. Hardisty Carolina Chapter of JF, the Stead AG, Society of Grose Toxicology Meeting on February 2, 1985. TFoaxcitcoorlsogiinfcluPeantchionlgolgaybo, r1a3t,or9y1-a1n0i4m,al19s8p5o.ntaneous tumor profiles. Hardisty JF. PStuelvmeonnsarMyA,anldinhgepJatWi,cJhaesaklotth eRfHf,ecHtasrodfisitnyhaJlFataionndoSftpeeatdroA.leTumhesmTooxkiec.olGogriosste, VEoCl,6, No. 1, March 1986. National Toxicology Program Pathology Quality Assurance Procedures, byJ.F.Hardisty aHnoadveGrA, JBoKorBmaalndw.inIn:aMndanAaFgiUnelgnCero.ndNuIcEtHaSn/dNDTaPta--QCuaEliWthiytmoifrTeo,xCicLolDoagvyiSetsudaineds,D(WBK Bristol, eds), pp 263-269. New Jersey: Princeton Scientific Publishing Co. Inc., 1986. PGurlomsoenEaCr,y lelfifnegctJsWd,uSetteoadshAorGt,tMeirlmleerxFpJo,sGurraehtaomoilJAfo,g.StSeevlegnrsadMeAMJaKn,d HHaartdcihstGyEJ,F. J Toxicol. & Environ. Health 21: 173-185, 1987. AMrosoirnem:anT,oxiJcFitHyarddaitsatyf,roSmLaEcuustteisa.nRdEsuMbocrhrrisosneiyc,iHnhRalaStainodneerxspoasnudreBs.A FMoPwleMro.orTmhaen, CR Toxicologist, Vol7, No. 1, February 1987. 26  . JERRY F. HARDISTY, D.V.M. - Continued . PUBLICATIONS AND PAPERS = Continued CHahrrdoinsitcy,toExiBciWthy oarntdoonnJcr.ogaenndicGtLy TseturdHyaoafr.2,T6hdeieTtohxyilacnoilloignies.t,TVGolPu8l,liNno,. RW Naismith, 1, February JF 1988. PMeorrigpahenraalndneJrAveSswhenebaetrhgt.umIonr:sI,LrSat,MobnyoDa.rM.apWhaslkoenr,PaVt.hEo.loWgaylklearb,orJaFt.orHyaarndiimsatlys,,KT Vneerrivaogu,s1s9y88s.tem, Vol 6, (TC Jones, U Mohr and RD Hunt., eds), New York, Springer HPautlcmho,naErCyGerfofsecet,sAduGeSttoeasdu,bcFhJroMnililcere,xJpAosGurraehtaomi,lMfoAg.StMeKveSneslgarnaddeJ,F GHaErdisty. Toxicology and Industrial Health, Vol6, No. 1, 1950. : Lo . . TBhoyorromiadng,landE,usbtyisJ,FCHaMrodnitsgtoymaenrdy,GAM BEowoelrlmaann.dIWn: PMaatchKoelnozgiyeo,fetdhse),F3S4a4n RDaite,go(,G : Academic Press, 1990. Oral cavity (pharynx, tongue, gingival teeth), esophagus and stomach, by HR Brown, JF HMaorndtigsotmyearnyd, SML EEluwsetlils.anInd: WPatMhaoclKoegnyzoifet,heedFs)3,44SaRnat,Die(gGoB,oAocramdaenm,icS Eustis, Press, C 1690. TEousxtiicso.loIgn:icParlopgartehsosloigny:Toxaicrciotliocaayl,s(tDagCelainyssotnu,dy| iMnutnerrpor,etPatSiohnu,bbiyk JanFdHaJrdSiwsetnybearngd,SeLds), Amsterdam, Elsevier, 1990. Tumorsof the skin in the HRA/Skh mouse afte treatment with 8-methoxypsoralen and VUoVlA16r,ad9ia2t-i1o0n.2,J1K99D1u.nnick, PD Forbes, SL Eustis and JF Hardisty. Fund. & Appl. Tox., } MProWlifAenrdaetrivseonl,esGioDnsSotfontehre,mBouWsGeaululn,g:JFPrHoagrrdeisstsyioannsdtuRdRieMsairnonStproati.n AExmpiecrei.meJnFtaFlolLeuy,ng Research, Vol 17, 157-168, 1991 : fLoersiHoenpsaotfoctahrecirnoodgenetnelsiviesr. inHaMredidsatkyaJFE. xpProesseednttoedWaatt etrhbeoDronseeN-RNeisrposoondsieetRyellaamtiinoen.ships Workshop on December 15, 1993 PSorcoiceetdyurofesTofxoircpoeloegrircePvaitehwolinogtiosxtic1ol3ogIinctpeartnhaotlioongayl. SHyamrpdoissiJtuFmy.oPnrJeusennet5e-d9,at19T9h4e. TNoexcircooplsogyicanPdathhiosltooglyo,gyUinnivteorxsiictoyloogficllpiantoihsolaotgyU.rbHaanrad-iCsthyamJpF.aiPgrne,seJnutleyd27a,t I1n9d9u4s.tral 27 Pp JERRY F. HARDISTY, D.V.M. - Continued PUBLICATIONS AND PAPERS -- Continued A comparison of iver tumor diagnoses from seven PCB 4tudies in rats. Moore John A, Hardisty Jerry F, Banas Deborah A and Smith, Mary Alice. Regulatory Toxicology and Pharmacology, Vol 20, 362-370, 1994. Neoplastic lesions of questionable significance. Toxicology Roundtable on October 3, 1994. Hardisty JF. Presented at the 1994 * TUosxeicooflnoagsyalRoduinadgtraabmlsetoonreOccolrodbenras4a,l1l9e9si4ons. Hardisty JF. Presented at the .1994 Morphologic assessment of pathologic changes in the rat larynx. Hardisty JF. Presented at the 1994 Toxicology Roundtable on October 4, 1994. Pathology peer review and PWG. Hardisty JF. Presented at the 1995 Toxicology Roundtable in Nashville, TN on October 23, 1995. Peer review in toxicology pathology. Ward JM, Hardisty JF, Hailey JR and Street CS. Toxicologic Pathology ISSN:0192-6233, Vol. 23, No. 2, 1995 Computerized pathology data ~ summary vs. individual. Hardisty JF. Presented at the 1995 Toxicology Roundtable in Nashville, TN on October 24, 1995. Aminceevaafltueartiionnhaolfatcihonanegxepsosiunrtehetoolmfeatchtyolreytehpyiltkheetloixuimmea.ndNeliwvteronpePrEo,xiBsoolmtee HpFro,liLfaekraetion in BMGa,rcDher1e89l6a.nko M, Rinehart WE and Hardisty JF. The Toxicologist, Vol 30, No. 1, Part 2, Peer review of histopathology data. Hardisty JF. Presented at the American College of Toxicology 17" Annual Meeting in King of Prussia, PA on November 11, 1996. Pathology peer review in the American College of assessing Veterinary Pcaatrhcoilnooggiesntisc'itTyhisrttuyd-ieFsi.rstHAarndniusatly JMFe.etPirnegseinntSeedattatle, `Washington on December 5, 1996. Value of the mouse carcinogenicity bioassay (Summary). Hardisty JF. Toxicologic Pathology ISSN:0192-6233, Vol. 24, No. 6, 1996, pp. 720-721 IBnltaecrka,ctAiMonDoafhcloenmsu,ltJaFntHsa,rdciosnttyr,acTtGlaTberorrealtloriPersesaenndtienddualsiIrnyd-usPtarnieall DTiosxcicuoslsoigoincwith HE Pathology, University of Illinois at Urbana-Champaign, May 19, 1997. TCoonxtircoovleorgsiicaPlaitshsouleosgyi,n Uanniavteormsiitcypoafthlollinoogiys.atJFUrHbaradnias-tyC.haPmrpeasiegnnt,edMaatyIn2d0u,st1r8i9a7l. 28 EPL coms . JERRY F. HARDISTY, D.V.M. - Continued ' PUBLICATIONS AND PAPERS - Continued Palhleenleclipnhhtehtaelreoiznyignoduusceps53t-hdeyfmiiccielnytm(p+h)ommiaces. aDcucnonmipcakniJKe,dHbayrdliosstsyoJfFt,heHepr5b3erwtilRdA,type. Seely JC, Furedi-Machacek EM. Foley JF. Lacks GD, Stasiewicz S and French JE. Toxicologic Pathology, Vol. 25, No. 6., 533-540, 1997. ADniangunaolstCiLc dDiavliesmmDaVsMinFtoouxnidcoaltoigoinc pCaotnhtoilnougiyn.g HEadrudciasttiyoJnerSryy.mpPoressieunmteadt NatorTthheCa2r2olina State University, College of Veterinary Medicine in Raleigh, North Carolina on June 14-18, 1998. MThoyursoei,d (aRnRd pMaarraotnhpyorto,idGgAlaBndoso,rbmyanJFanHdardBiWstyGaaunld, eGdAs),BoVoiremnanna., IILn,: CPaacthhoeloRgiyvoerfPtrheess, * Lo . 1999. aRnoddernetlelveaydnicge cteollhtuummaonrso.geJnoesniCs:Coaorke,viGeawryofRthKeiipnheyfeslitoelro,gJye,rrpyatFhoHlaorgdyi,stmye,cRhiacnhiasrmdsM, Sharpe and Paul MD Foster, Critical Reviews in Toxicology, 29(2): 169-261, 1999. `The nomenclature of cell death: recommendations of an ad hoc committee of Society of TEoKx,icMoalroognipcoPtatRhoRloaginsdtsT.ruLmevpinBFS., TBouxcicciolTJP,atChoolh.en19S9M9,JuFilx-AAuSg,;2H7a(r4d)i:s4t8y4-J4F,90L.egrand Controversial issues in anatomic pathology. Hardisty Jerry. Presented as a course tenhteitRlaedmIandduastIrninalinToBxeitchoelsodgay,aMnDd PoanthSoelpotgeymfboerrth2e8,Am1e9r9i9.can Registry of Pathology at Hciosntdoupcattehdolwoigtyh ovfolnataislaelcohlefmaicctaolrsy.muHacrodsiastfyrJoFm, selected Garman inhalation toxicity RH, Harkema JR, studies Lomax LG . and Morgan KT. Toxicologic Pathology. Vol.27, No. 6, pp. 618-627, 1999. MPaetehtoilnoggoyfWtohrekSioncgieGtryooufpsQ:uaCluitryreAnstsCuornacnecpetsin. MHoanrtdriesatly,JFC.anPardeaseonnteOdctaotbtehre81-61"3,An2n0u0a0.l Blind Pathology ~When and When Not. Hardisty JF. Presented at the 51" Annual Toxicology Roundtable Program in Asheville, NC on October 15-18, 2000, aShnodrJt-RTeHaryme,s.SubInchPrroinnicci,plaensdaCnhdroMneitchoTodxsicofolToogxyicSotluodaiye,s,4byEdNitHioWni,l(sWoan,llJaFceHaHradyiesst,y ed), ISBN 1-56032-814-2, 2000. Methods to identify and characterize developmental neurotoxicity for human health risk aasnsdesFsemreenntc. S.I: neuropathology. Garman RH, Fix AS, Jortner BS, Hardisty JF, Claudio Environmental Health Perspectives, Vol. 109, pp. 93-100, March 2001 L 29  ee rrr-- A-------- JERRY F. HARDISTY, D.V.M. ~ Continued PUBLICATIONS AND PAPERS - Continued ANecwhtroonniPcEi,nhWaolaotdiionngtoWxLic,itByollotnecoHgFe,niDcetryesltaundkyo oMfJm,etHhayrdliestthyylJkFetaonxdimReinienhraartts WaEnd.mice. Inhalation Toxicology, 1311083-1116, 2001. Carcinogenic JA, Clare LJ, BaasrsneesttsmDe,nHtilofdepbrreamnadftioP,xaHcairndiisntryatJsFaannddmLicuec.asWhMiJ.te PKrAe,seDnatneiedlaEsMa, Botta poster for Societies the Society of of Toxicologic PTaotxhiocloolgoigsitcsPiantOhrollaongdyo,anFdlotrhiedaInotnerJnuatnieon2a4l-2F8e,de2r0a0t1.ion of sQtuuadliietsy: rTehveieNwaptirooncaelduTroexsicnoelcoegsysParroygfroarmroEdxepnetripeantcheo.loBgyoodramtaanbaGsAe,s aHnadsteomxaincoJgKe,namic, Waters WD, Hardisty JF and Sills RC. Toxicol. Pathol. 30, 88-92, 2002. Inhalation toxicology of octamethyicyclotetrasiloxane (D,) following a 3-month nose-only eMxRp,osHuarrdeisintyFiJsFchaenrd3T4h4ervaetsn.azBuPr.nsIn-tNearanastiLoAn,alMJeoeukrsnalRGo,f TKooxliecsoalrogGyB,,IMSaSsNt1R0W91,-5Ei8w1e8l,l Vol. 21, No. 1, pp 38-53, 2002 Diagnostic dilemmas in toxicologic pathology. Presentedatthe 5" Industrial Toxicology and Pathology Course and symposium in Chicago, IL on July 9, 2002. Histologic artifacts & diagnostic dilemmas. Presented at the RTP Rodent Pathology Course, Research Triangle Park, NC on September 8-10, 2002. . Comparative prevalence, multiplicity, and progression of spontaneous and vinyl FcoalrebyamJaFtea-nidndMuacreodnploivterRlRe.siToonxsiicnolfoivgeicstPraatihnsoloofgym.alVeolmi3c0e,. NToa.k5a,hapsph5i99K,-6D0i5n,s2e0G02E., Propylene glycol Fischer 344 rats monomethy and B6C3F1 emitchee.r (TPoxGiMcEo)l:ogiicnhPalaatthioolnogtoyx,icViotly a30n,d Ncoa.rc5i,nipgpen5ic7i0t-y57in9, 2002. A`enxpeovsaulrueattioomneotfhyclheatnhgyelkseatonxdimree.coNveewrytoinn tPhEe,oBlfoalctteorHyF,epDietrheelliaunmkoinMmJi,ceHaarfdtiesrtiynhJaFlaatnidon Rinehart WE. Inhalation Toxicology, 14: 124-1260, 2002. The pathologist and February 29, 2002. pathology data. Hardisty JF. Presented at NIEHS, RTP, NC on TNahsehvpialtlheo,lTogNisotnaMnadrpcahth2o0l0o2.gy data. Hardisty JF. Presented at the SOT Meeting in The pathologist 2001 and pathology data. Hardisty JF. Presented at FDA CEDR on May 31, 30  . JERRY F. HARDISTY, D.V.M. - Continued : PUBLICATIONS AND PAPERS = Continued Histologic artifacts and diagnostic dilemmas. Hardisty JF. Presented at NCTR in Jefferson, AR on October 31, 2002. `The pathologist and pathology data. Hardisty JF. Presented at NCTR in Jefferson, AR on Oclober 31, 2002. . `The pathologist and pathology data. Hardisty JF. Presented at Health Canada in Ottawa, Canada on December 2, 2002. Necropsy and histology techniques. Hardisty JF. Presented at FDA on January 9, 2003. CCuorlruemnbtusa,ppOroHacohneJsutnoeP5e,er200R3e.view and PWG. Hardisty JF. Presented at Battelle in ! a . CChlaaryatcotnerNi,zaHtaridoinsotfy iJn,traantdhoPraecaircsmeeGs.otPhreelsieonmtaedinaFsisacphoesrt3er44f/orNtrhaets.SocWiieltlysoonf G, Toxicologic Pathology, 22 Annual Mesting In Savannah, Georgia on June 15-19, 2003. Transplacental carcinogenicity of azidothymidine in BEC3F1 mice and F344 rats. Walker 2D0M0,4HIatridniesrtayryJPFl,anRnueerc.keBraltFiAm,orFeu,nkMDK:A,SoWcoileftey oMfJToaxnidcoWlaolgyk.er VE. Abstract No. 548. sCeocmtpiaornsision nanofNaTuPtoSmuabtcehdrosnoifctwBairoeaswsiatyh.coWnivlelnstoinoGnaAl,hJiosrtoonpaTtAh,olLoegsynoifakivDe,r sPteeaprse G a20n0d4.Hardisty JF. Presented a poster at the STP Meeting in Salt Lake City, UT, June, TAouxtiocmoaltoegdy RPoautnhdotlaobglyeS,yAsutgeumssta~, HMIu.mSaenpt.Ve2r0s0u4s. Machine Vision. Hardisty JF. ' HCaormdpiasrtaytJiFveanhdepBartiixcAtEox.iciTtoy:xicporleocghirconPiactlhcohlroognyi,c 3li3v:e3r5t-o4x0ic,it2y00i5n.rodents. ACTISTP Pathology Course for Non-Pathologists. Hardisty JF. Speaker at ACTISTP Meeting, Lincolnshire, IL, May 10-13, 2005. a HARDISTY. 4 Wy Velerinary Pathologist DA ous 31 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, ING. . GABRIELLE A. WILLSON VETERINARY PATHOLOGIST EDUCATION: Glasgow University Veterinary MRC Path (Membership of the School B.V.M.S,, Royal Collage of 1873-1977 Pathologists), 1985 FRC Path (Fellowship of the Royal College of Pathalogists), 1995 PRESENT POSITION AND EXPERIENCE: Ll 01/04 -- Present. VReetseerairnacrhyTPraitahnoglloegiPsatr,k,ExNpCerimental Pathology Laboratories, inc., aPrpoavritdteismpeabtahsoisl.ogyThsiusppionrvtoltvoeCsHiInTt,eCraecnttieonrswiftohr Health staff at Research al levels ainndRepasretaicricphatTiroinainnglmeaPnayrk, on 1d0ivsetrusdeyadreesaisgnr,anpghiontgogfrraopmhyt,heptoescthenricparlepaasrpaeticotns,ofimtaisgseueanparloysciess,sicnognfaoncdalnmeiccrroopsscyoptye,chenlieqcuterosn microscopy pathological and immunohistochemistry lesions. in addition to the routine n:ecropsy and interpretation of 09/00 - Present VReetseerairncarhyTPraitahnoglloegiPsatr,k,ExNpCerimental Pathology Laboratorieis, Inc., tDiustsiueessafsraomstvaafrfipoautshloalboogirsattoirnyparneismeanltspaosnidtiaoundiattsEoPfLpaitnhcoluldoegyhidsattoapaatnhdolsopgiecciimnteenrspreutsaetdiofnorof toxicity and carcinogenicity studies. 03/00 - 07/00 ASancartaommeinctPoa,thColAogist, IDEXX Veterinary Services, West iRnesdpeopnesnidbeinlttibeisotiencchlundoeldogpyercfoomrpmainnigesh,ispthoapartmhaocleougtyicoanl rceosmepaarcnhiesstuadnieds usnuivbemristitteyddbeypartments. Also, in par, provision of diagnostic histopathology service for veterinary clinicians. 12/96- 12/98 AVretaebriEnmairryaStuesrgeon, The Animal Care Centre in Sharjah, United Functioned in a clinical capacity as a veterinary surgeon. 10/91 - 12/96 Independent Cheshire UK Toxicological Pathologist, Histo-Logic, Stalybridge, 32 EPL EXPERINENTAL PATHOLOGY LABORATORIES, ING. * GABRIELLE A. WILLSON, B.V.M.S, MRC Path, FRC Path- Continued PRESENT POSITION AND EXPERIENCE - Continued iSinndceepeAnudgeunsttp1a9t9h1o,lofguyncctoinosnueldtaanscya.coPnesruflotramnetdpaptahtohloolgiosgtyeosntaablniushmibnegrHiofstsot-uLdoigeisc,anadn aiso ppeerrffoorrmmeedd ipneehrourseevi(eWwasroef)sotrudaitecsofnotrraGcltaxfoacWieelscoanmdeo(fWnaercee)s.siTthyeisnevosltvueddiecslowseerleiaeiistohnerwith the other scientists involved. aRbeoardataorviaersieitny booftshttudhieeUsniinteadtsK,imnigcde,omdoagnsd aenldsemwihneirpeigisn fEourrcoopnet.racHtisatnod-Lootghieorwpahsaramcaocseputteidcal into the United Kingdom Department of Healths GLP Compliance programme. . 10777 - 06/1 Serio Pathologist, Unilever Research, Shambrook, Bediord UK " tReersmpotnessitsbiilntreosdeinntcsl.uded postmortem and histological assessment of short, medium and long- AacntdeadtacsonSttruacdty lDaibroercattoorrifeosr.all teratogenicity studies for several years conduced both in house Management of the Teratology Department with direct responsibilty for a staf of four. Achievements During This Period: iCnosmtpillaettioino,nionfraaplleaurrgaelnaunmdbeinrtroafpteersittsoneenalcoimnjpeactsisoin,nginftereadvianggi,nailnhiansltaitliaotni,oninatnradtrtaocphiecaall aapsplpiacrattioofn.theUletvraalsutartuictounraplroecxeassm.ination and histochemical assessment were frequently required : iSnovleestriegsaptoinnsgibtihletlyffeotritmheeefhfiescttosloogfifciablraosussemsisnemreanlts.of a vast and complex intrapleur.al study Production of reports, most of which were submitted to Regulatory Authorities. UOnvievresresietiyngMeadiscuaclceSscshioulolcoilnltahbeoraarteivaeofprionj-evcittrwoittehcthhneiqAuneastfoomrythDeeapsarstemsesnmtenotf Lofeiscmesbtreyro wCuhleturree.it wThaissutseecdhniinqtuheewaassseastesrmetnrtanosfieprorteednttioalthteerEantvoigernosn.mental Safety Laboratory af Unilever Formal presentations of results of studies both within Unilever and to the operating companies. Cgaurirnyeiangpiogus,t rbaabcbkitgsroaunnddirnevessetairgcahtitoonmoafisnpteaciinfitcheprhoeballetmhs.of the breeding colonies of rats, mice, 33 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, ING. . GABRIELLE A. WILLSON, B.V.M.S., MRC Path, FRC Path - Continued PRESENT POSITION AND EXPERIENCE - Continued , 07/77 - 1077 SLuorcbiutmonw,orsku,rrHeeynUdKerson & Keywood Veterinary Surgeons . pLrooccuedmurweosr,k eint.a busy small animal practice. Duties included consultations, surgical PROFESSIONAL MEMBERSHIPS: . Fellow of the Royal College of Pathologists British Society of Toxicological Pathology CSohcairelteysoLfoTuoixsicDoavliosg,icDP.aVt.hM.olFooguyndation PRESENTATIONS AND POSTERS: IDinsdcuucsesdioMnesGortohuepl,i2om2andinMteheetiWnigs,taLriaRnadt.udnWoil,lsNoonr,thG,Waplreess,enSteepdtaetmtbheerI1n9du9s2t.rial Histology `pSrpeosnetnatneedoautstahnedBISnTdPucMeodduPlaatrhoEldougcyaotfiotnhePSraoligvraarmymGelainn dTsoxaicnodloOgeiscoaplhPaagtuhsol.ogWyi,llCsaomnbrGi,dge, England, July 20, 1993. : MCaordduiloavrasEcduulcaartiSoynstPermo:grSapmomnetainneToouxsicRoloodgeinctalPPaatthhoollooggyy., WCialmlbsorni,dgGe.,,pErnegsleanntde,dJautlyth9e-1B2S,TP. 2001. : THoerpiatMo,bSlialslstoRmCa,sWiinllMsiocneGiAn,thHeerUbSerNtatRiAo,naHlaiTloexyicJoRl,ogHyasPeromgarnaJmK(NaTnPd)BSotoudrimesa.n GTAu,rupsroevseVnSt,ed atthe STP Meeting in Denver, CO, June 2-6, 2002. HChaarrdaicstteyrJizaantdioPneoafrIsnetrGa.thPorreacsiecnMteedsoatshealpioosmtaerinfoFritshceheSroc3i4e4t/yNoRfaTtosx.icWoillogsiocnPGa,thCollaoygtyo,n2N,2 Annual Meeting in Savannah, Georgia on June 15-19, 2003. TPorxeisceonltoegdictoPatthheoHleoaglytohfPtrhoeduIcnttsegaunmdenFtoaoryd SBryasntcehm, aOnffdicteheofMCaomnmtianruyinGglEadnudc.atWiiolnl,soOnntGa.rio, Canada on January 20, 2004. NThTePUSsteudoifesA.utPoemaartseedG,PaJtohroolnogTyA,SoLfetswnairaektDo,CWoinlflisromn tGheA RaensdulHtasrdoifsPtaythJoFl,opgriceaslenEtveadluaatpioosnteorf atthe STP Meeting in Salt Lake City, UT, June, 2004. 34 EPL EXPERIMENTAL PATHOLOGY.LABORATORIES, INC. ! GABRIELLE A. WILLSON, B.V.M.S., MRC Path, FRC Path - Continued PUBLICATIONS AND PAPERS: HSCaeorcmdtpiiasortnyissJioFnn,apnofrNeAsTuetPnotSmeuadbtacehdprooPsnatitechroBaltiootgahysesSaSoyfT.tPwWaMireleeltswioitnnhgGCAion,nSvJaelontrtoLinaoknTeaAl,CiHLtieys,stnUoiTpa,aktJhDuo,nlePo,egya2r0osf0e4L.iGvearnSdtep EtMhnoegdlupalrneodg,1r3Ja:umlmMyues5)-c,9u,lBo2Ss0Tk0eP4l.eMtoadluSlyasrtEedmu,caStkiino,n SPurboegurtasmamnedinMaTomxmiacrolyo.giGclaalndP.atWhiollsogoyn,GCa(mobrrgiadngieze,d PGaotmheola.l1L9i8p0oiJduols;i1s7(i4n)a:4D9o0-g3.with Bilateral Thyroid Carcinoma. Harrington GA and Kelly OF. Vet .: A Lymphomatoid Granulomatosis of the Lungs in Young Dogs, Lucke VM, Kelly DF, Harrington . GA, GibbsC and Gaskell CJ. Vet Pathol. 1979 Jul:16(4):405-12. . THoerpiiatMo,bSliallsstoRmCa,sWiinllMsiocneGiAn,thHeerUbSerNtatRiAo,naHlaiTloexyicJoRl,oHgyasPeromgarnaJmK(NaTnPd)BSotourdimeasn. GTAu.rusov VS, `Toxicologic Pathology, Vol. 30, No. 5, pp 560-591. GMARBCR.IVE.LSL.E,AF.RWCI.LPLaStOhN, BV.MS., Date rerdoe/ 87 35 CURRICULUM VITAE - 2004 : NAME W. Ray Brown, D.V.M., Ph.D. Diplomate, American College of Veterinary Pathologists PRESENT POSITION Consultant President, in Toxicologic, Pharmacologic Research Pathology Services, & Inc. Experimental Pathology + 438 East Buller Avenue, New Britain, PA 18901 Telephone: 215-345-7070 Fax: 215-345-4326 e-mail: WRBRPS@concentric.net EDUCATION Degree Year . Pennsylvania State University University Park, Pennsylvania New York State CollegeofVeterinary Medicine `Comell University Ithaca, New York NewYork State College of Veterinary Medicine Comell University-Veterinary Pathology Ithaca, New York BS. 1961 DVM. 1964 PhD. 1967 PREVIOUS POSITIONS Independent Consultant in Toxicologic, Pharmacologic and Experimental Pathology Director of Toxicology and Pathology Merck Institute for Therapeutic Research West Point, Pennsylvania : . . 1973 - present 1972-1973 Director of Pathology Merck Institute for Therapeutic Research West Point, Pennsylvania 1970-1972 Senior Research Fellow of Pathology Merck Institute for Therapeutic Research West Point, Pennsylvania 1969-1970 Research Fellow of Pathology Merck Institute for Therapeutic Research West Point, Pennsylvania 1967 - 1969 36 CWu.nRiacyulBruomwnV,itDaeVM- .20,04Ph.D. ' PREVIOUS POSITIONS (Continued LaboratNoreywInYsotrrukctSotra,teVeCtoelrliengaeroyfPaVtetheorliongayry Medicine Comell University Ithaca, New York 1984 - 1967 NIH Trainee New Yion rVketSetraitnearCyolPlaetgheoloofgVyeterinary Medicine Comel University Ithaca, New York : * 1964-1967 ACADEMIC AFFILIATION . JAsesfifsetrasnotn PMreodfiecsaslorC,olDleepgaertment of Pathology ! . Thomas Jefferson University Philadelphia, Pennsylvania : PROFESSIONAL SOCIETIES `AAmmeerriiccaann VCeotlelreignearoyf VMeetdeircianlarAyssPoactihaotlioognists : PInetnenmsaytlivoannailaAVceatdereimnyaroyfMPeadtihcoalloAgsysociation ASomceireitcyaonfSToocxiiectoyloogfyVeterinary Ciiical Pathologists SIontceirentaytioofnaTloxUincioolnogoifcPPhatahromlaocgoisltosgy (Section of Toxicology) SChiagrmlaesXiLouis Davis, DVM Foundation . OPhmieZgeataTNaautiSoingalmaVePtreorfiensasriyonHaolnoVretaerryinSaorcyieStoyciety OTHER SPECIALTY DirectorD,eEplaercttmroenntMiocfrSoasfceotpyyALsasbeosrsamtoernyt WMeersctkPoIinnstti,tuPteenfnosryTlhvearnaipaeutic Research 37 CW.urRraiycuBlruomwnV,itDaeVM- 2,00P4h.D. . CONTINUING EDUCATION/PROFESSIONAL MEETINGS AAnmneurailcaMneeCtoilnlgege of Veterinary Pathologists | Baltimore, MD - October 31-November 3 MNaotuisonealPuTloxmiocnoalroygyCaPrrcoignroagmen-esNiIsESHySmposium Research Triangle Park, NC - March 27-28 Society of Toxicology Annual Meeting Miami Beach, FL - February 12-15 `AAnmneurailcaMneeCtoilnlgege of Veterinary Pathologists Phoenix,AZ - December 10-13 Society of Toxicology Annual Meeting Dallas, TX - February 25-28 : Drug Information Association Recent Considerations Evaluation of Rodent on the Design, Carcinogenicity Interpretation Studies and Rockville, MD - September 30-October 1 American College of Veterinary Pathologists Annual Meeting Orlando, FL - December 9-13 : ASnocniueatly MoefeTtoixnigcology Seattle, WA - February 24-27 SXiocIinetteyrnoaftiToonxailcoSlyomgpicosPaituhmologists ToxicoloPghiocenPiaxt,hoAlZog-yMoafyth3e1-HJeumanteo4poietic System National Research Council Role ofWTaosxhiiconlgotgoinc,PDatCho-lFoegbyriunarSyaf8e.t9y Assessment . . 1989 0 1990 :. 1990 1990 1991 : 19.91 | 1991 1992 1992 1993 38 CW.uRaryrBriowVcni,tuaDe.l-VM2u.0,m04Ph.D. : CONTINUING EDUCATION/PROFESSIONAL MEETINGS (Continued) Society of Toxicology Annual Meeting New Orleans, LA- March 15-19 1993 Society of Toxicologic Pathologists Xil International Symposium Regulations Governing Toxicologic Pathology Washington, DC - June 27-July 1 ' 1993 GRirsokwAthssFeascstmoresntan(d7TIunmtoermaPtrioomnoatliCono:nfeIrmepnlicceatoinons for Carcinogenesis and Risk Assessment) Austin, TX - December 14 co . 1993 . International Life Sciences Institute ' 5" WorkAsrlhionpgtoonn,MVoAus- eNoLviveemrbTeurmo7-r9s : 1994 Society of Toxicology Annual Meeting Baltimore, MD- March 5-9 . 1995 Society of Toxicologic Pathologists 14% International Symposium San Diego, CA - June 11-15 1995 Staging of Rat Testes Two-day short course by Dr. L. Russell Rohm and Haas Company Spring House, PA - February 26-27 . 1996 MSipdr-iAntglaSnctieinctiCfhiacptMeers,tiSnogciety of Toxicology Kenilworth, NJ - April 25. : 1996 S4o5c"iIenttyeronfaTtoixoincalolSogyimcpoPastihoulmogists. ToxicoloSgticLoPuaitsh,olMogOy-aJnudneRi8s-k1A3ssessment 1996 AAnmneurailcaMneeCtoilnlgege of Toxicology Valley Forge, PA- November 11-13 1996 39 "CurW.riRcauylBuromwnV,itDseV.-M2.0,04Ph.D. . . . CONTINUING EDUCATION/PROFESSIONAL MEETINGS (Continued ASnocniueatly MoefeTtoixnigcology ' Cincinnati, OH - March 9-13 1997 Society of Toxicologic Pathologists 16" International Symposium . Toxicologic Pathology Beaver Creek, of the CO Kidney and June 22-26 Urinary Bladder 1997 American College of Veterinary Pathologists `Annual Meeting Albuquerque, NM -- November 16-21 ., 1997 " ASoncniueatlyMoefeTtoixnigcology New Orleans, LA - March 14-18 1999 ASnocniueatly MoefeTtoixnigcology Philadelphia, PA - March 19-23 2000 ASnocniueatly MoefeTtoixnigcology Nashville, TN - March 17-21 ) . 2002 AClhtaerrlneastiLvoeusitsoDtahveisR,odDeVnMt BFioousnadsastaiyonin Assessing Carcinogenicity| New Brunswick, NJ-April 5 . 2002 `AAmnenruialcaMneeCtoilnlgege of Veterinary Pathologists New Orleans, LA- December 7-11 2002 Charles Louis Davis, DVM Foundation DermatoNpeatwhOorlloegaynsS,yLmApo-sDieucmembe7r 2002 American College Annual Meeting of Veterinary Clinical Pathologists New Orleans, LA - December 7-11 2002 40 WC.urRraiycuBlruomwnV,itDaeV-M20, Ph.D. : CONTINUING EDUCATION/PROFESSIONAL MEETINGS (Continued) Charles Louis Davis, DVM Foundation Gastrointestinal Toxicologic Pathology New Brunswick, NJ - April 25 2003 PATHOLOGY WORKING GROUP (PWG) PARTICIPANT . National Toxicology Program -Dioxin- Re-evaluation study (1990) of hepatic tumors from the 1978 Kociba rat -Dioxin- oPanrttihceipraenstulattstohfethBeanrbeu-ervyalCuoantfieonreonfctehse(rCaotlldivSerprtiunmgorHsar(b1o3r9)0) ` -PCBs-Re-evaluation of the rodent liver tumors from the Aroclor * 1254 and 1260 and Clophen A30 and ABO chroniconco- . : , ~Severalindustgreinailc-istpyornastorsetdudPieWsG(s19o9n1)chemicals, agrochemicals and phamaceuticals : HISTOPATHOLOGY PEER REVIEW for sePveerealrrdeovmieeswtoicfhainsdtopianttehronlaotgiyonaslidpehsaramnadceduattiacahlavaenbdeecnheamnidcaalrecobmepianngiepse,rfotrrmaedde groups, and consortiums on toxicity and carcinogenicity studies. EXPERIENCE IN TOXICOLOGY AND PATHOLOGY the desAicgtni,vistiuepseravsisaiocno,nseuvlatlaunattiionn,toaxincdolorgeipcoratnindgpohfartmoxaiccoiltyogaincdpactahroclinooggyenhiacvietyinsctluuddieeds ainnviomlavlisngusvaerdioiunsthcehseemisctauldieasndinpcoltuednetiraoldetnhtesra(preautts,icmiocre,bihoalomgsitcerssu,bsgtuainnceeas.pigsL,abroarbbaittosr)y, cats, dogs, marmosets), nvoanr-iohuusmaanviapnrismpaetceises(R(hcehsiuckse,nsc,yndoucmkosl,gutsurkaenyds, African quall, agnrdeemninmiaotnukreeysswianen.d The types inhalation of experiments in exposure studies, the areas parenteral osftiundiveoslv(eimnetnrtavehnaovues,beientnraomruaslcutolxairc,itydeerxmpaelr,imoecnutlsa,r astnuddiessu,bcauntdahniesotoulsogiirciteavtailounatsitoundifeosr),sacfaertcyitneosgtesniocfitvyarieoxupserviamcecnitnse, prreepparroadtuicotniso.nfteratology Responsibilities in these terpretation and detailed reporting various experiments of antemortem data have (clinical included signs of evaluation, toxicologic inand ppohsartmmaocrotleomgicdaeftfaects()o.reglaenc_trwoeciagrhdtiso)l,ogy,grhoesmsatoalongdy, serum biochemistry, microscopic tissue urinalysis, and examinations, histochemistry and electron microscopy. 0 WC.urRraiycuBlruomwVni,taDeV-M2.004PhD. . . . methodsReaponrdtirnesgulotfs, tchoencalbuosvioensd,ataandhassafeitnyclausdseedssprmeepnatraotfiotnheovfasriuomumsaraigzeanttisonbsasoefd tohne the and results. These reports are written domestic regulatory agencies, e.g., insuaiptparbolperifoartesufbomrimsastisonforfosruIbnmviesstsiigoantitoonailntNerenwatiDornuagl D(IeNpDa)rtamnedntNoefwAgrDircuulgturAep,plNiactaitoinoanl (CNaDnAc)erwIintshtittuhtee aFnododEnvainrdonDmreungtalAdPmriontiescttriaotnioAng,enUc.y.S. has In addition to primary included selection as the pSroocjieecttypaorftiTcoixpiactioolnogayndTamsokniFtoorrcineg,paptheoelrogriesvtietwo experience perform an independent pathology review of the urinary bladder and hepatic neoplasms in the FDAINCTR committees ED, mouse carcinogenicity study and for review and interpretative opinions participation in several select on pathology sides and data panels and for various sponsors, as well as international and domestic regulatory agencies. Many of these reviews and representations have involved findings and interpretation of hepatic and endocrine toxicity and potential oncogenicity. 42 CW.urRraiycuBlruomwnV,itDaeM- .2004Ph.D. ' PUBLICATIONS: 1. Christian, Studies in M.S. CRL aSnpdraBgruoew-nD,awWl.eRy.,("CGoonltdroSltaPnrdiamrodr"d)iaRlatFsol,iTcolxeicCooluognitcs, iSnciMeunlcteisge,n6er-a1t-i5o,n 233 (2002) 2. YReoprrkoduRctGi.on SBtruodwynof AWmRm.oniGuirmarPde,rchMloFr.ateainn dDriDnoklilnagrhWiadte,erJiSn.presTs)w.oGeneration 3. CHraurzdya,n, G.C, J,CushCmoaonm,bsJ,R. `AnDdWr.ews,MuLlSi.n,s,GranPviAlle, aGi.Cd., JBorhonwsno,n, WKAR,.BevCahnr,onCi.c, TWoexeikcsi.lylJO.ncAopgpelniiecditTyoxSitcuodlyogyof21S:i1y8r5e-n1e9i8n (C2D00-11).Mice by Inhalation Exposure for 104 4. CCrouozmabns,,G.B,WC.ushMmulalnin,s,JR., PA.An.darnedwBsr,owLnS,.W.GRr.a,nvCilhlreo,niGc.CT.o,xiJcoihtnysloOnn,coKgeAn.iciHtayrSdtuyd,yC.oJf, . = *+ Styrene (1998) in CD Rats by Inhalation Exposure for 104. Weeks. Toxicol. Sci. 46:266-281 : ! 5. FCoPrb.es,BrPo.wD.n,, TaWkRiz,awaa,nTd., PHaarskheirm,otRo,MK.., Y7a8m-aWsehietka,PSh,otHoocbaercrimnaong,enAeMs.i,s SSatmubduycoo,f TGorxeipcaoflioogxiaccailnSciaenndcesC,o4m2p:a1r-a5,to5r0-5A1r,ti1cl9es. Administered Orally to Hairless Mice 6. SWaRm,bucoS,taCl.eP,, PPoLw.ers,SWtr.eetJe.r,,DemApJs.tera,ndM., PHaorbkeerr,manR,MA.M.1F3o-rWbeees,k P.SDu.,bcBhrroownni,c HPahiortioetsosxiMciocleo.gyToxSitcuodlyogiocfalleSvocfileonxcaecsin,,42A:1Q-uSi,n5o1l,on1e99A8n.tibiotic, Administered Orally to 7. WPaRrk,er,`SRteMll,ar,PoSwMe.rs", WSt.rJe.c,teDre,mpAsJt.er,aAndM.FoHrobbese,rmaPn.,D.,AM.1,20SMaomnbtuhcoO,raCl.P.(,GaBvraogwen), 4P2ho1t-o5c,ar5c1i,no1g9e9n8i.city Study of Levofloxacin in Hairless Mice. Toxicological Sciences, . 8. MinanFliesyc,heAr.,3B4r4owRna,ts:W.LRa.ckanodf MEefnfencetaro,f CJ.hroDincihcioArdvmoisniasntdraMtioonnonounclPeraorgrCeeslsliLoenukofemtihae Disease. International Journal of Toxicology, 16:1-7, 1997. : 9. BStruodwine,s Wwi.thRL:-tryCpotmoppahraantainvde CHoinssttoiptuaetnhtosl.ogiJcouErvnaalluaotfiRohneoufmaAtnoilmoaglyS(t2u3d,ieSsu:pplMeumreinnte 46), 99-110 (1996). 10. Patterson, Prolferative Dl.eRsi.onsHaomfltihne, adMrHe.n,al gHloatntdesndionr,rats.G.H.In, GuGioduegsh,forAT.oxaicnadlogBircowPna,inoWloRg.y,. STRIARPIAFIP (1995). 11. oBnrotwhne,RWa.t PRi,ttFeyt.ter,ToAx.iDc.o,logViacnPaRtyhzionl,ogRy.J2.1(1a)n:d8L1a-n8g6lo(s1s9,63)J..M.: Effects of Calcitonin 43 WC.urRraiycuBlruomwnV,itDaeV-M2,004Ph.D. . . . PUBLICATIONS (Continued) 12. tMhceGTeoex,icJ.olHo.g,yBanud CtaWrcHli.noeWgielnriegsai,ns,StD.udAie,sBorfowlno,diWn.atRed.,GlayncderSoolfiian, FR3.4D4./:NCrRiaitqsueanodf BEC3F1 Mice. Regulatory Toxicology and Pharmacology 18, 166-180 (1993). 13. Newberne, P. M., Proliferative Liver Carlton, Lesions W. W., in Rats and Fed Brown, W. R.: trans-Anethole Histopathological Evaluation' of in Chronic Studies. Food and Chemical Toxicology 27(1): 21-26 (1989). k 14. WHaegeakn,WJh. oVl.e,F-iBsohdeyr,aJn.dR.N,oBsreo-wOnn,lyW.InRh.alaantidonBaTlodxwiicni,tyR.oCf.MCanocmozpeabriniosRfatqtsh.ne Two- The Toxicologist (1): 196 (1987). . 15. DMiazyenFse,eMd.i,ngBrSowtnu,dyW.anRd.,OLnaeve-gGieinae,rJa.t, iKoinleeRne,prJ.odCu.ctainodnIgSntautdosykii,n J.RaAt:s CwoimthbiEntehdyl305-- 4Cy1a7no(-139,844)-.Diphenyl-6-OXO-1(6H|-Pyridazine-acetate (DS-29308). The Toxicologist 16. AFordA, W.30H-.D,ayAulTeotxtiac,itCy. SSt.,uBdryoiwnnD,ogWs. wRi.t,hLaEvtehgyllia5,-CJ,y.anKoil-l3e,e4n-,DJi.phC.enyaln-d6-IgOnXaOt-o1sk[i6,H}J.. Pyridazine-acetate (DS-20399). The Toxicologist 4:18 (1984). 17. FGeoendgiwnegr,StLu. dEy., oAfulAe-t1t3a2,-1C.32S0.,iRniTnherhearetS,tWra.inEs.,ofanFdemBalreowRantWs,., R.: Mannitol Report of ICI Il Lifetime Americas, (In4c.v,olWuimlemsi)n,gtDoonc,kDetEs aMnadnaBigoe/mdeynnatmiBcrsa,ncIhn,c.,FDEAa,stRoMciklvlisltloen,e,MNDJ. Docket (1978), No. 74-2185 . 18. AEdmeenroyv,irJ.usB.T,ypHeous2e,byJ.CaAn.,inaendAdBernoowvni,rusW.TyRp.:e C1roVsasc-cPirnoatteicont.ive AImmemruinciatny JtoourCnaanlinoef Veterinary Research 33(11): 1778-1783 (1978). 18. Goldlust, Differing M. B., Rich, L. Schedules for GI.n,iraan-adrtBicruolwanr,CWh.allR.e:ngIemmwuitnhe Synovitis Antigen. in Rabbits. American Effects Journal of of Pathology 91(2): 329-343 (178). 20. Apostolou, on Water AC,onsSauimdptt,iLo.n,,anBdodBryowWne,igWh.t,R.:BlEofofdectSaofmpOlvienrgn,ighatndFasBtlionogdofCoYmopuonsigtiRoant.s Laboratory Animal Science 26(6): [Part 1], 959-960 (1976). 21. LZweivcokdeoyp,a.R.ToEx.i,coBlroogwyn,anWd.ApRp.lieetdaPl:haPrrmeaclcionlicoaglyT2o8x:ic1o8l1o-g1y95St(u1d9i74e)s. of Carbidopa and 22. DBroogwnI,ndWu.ceRd.,byRuabiSna,lcLy.l,aHniiltdee.M,.TaonxdicZowliocgykeayn,dR.ApEp.:lieEdxpPehrairmmenatcaolloPgaypi21l(e4)d:em5a32in-5t4h1e (1972). 23. Brown, W. Laboratory RA.:niSmiaglnsifuiscaendceinofPhSapromnatcaonleooguys Diseases Research. of the The CLeanbtorraaltoNreyrvAonuismaSlysinteDmruign GTeesrtimnagn.y, F1i9f7t2h.International Committee on Laboratory Animals Symposium, Hanover 44 Curriculum Vitae - 2004 W. RayBrown. DV.M., Ph.D. ! PUBLICATIONS (Continued 24. Watson, L. S,,Riley,R. L., Connelly, The Electrolyte Excretion Pattem M. T., Russo, H. of Amioride F, BrownW,. R. and Following Ureteral BaerJ,. E. Retrograde Inttaluminal Injection. Federation Proceedings 30: 337 (1971). 24. VLoacnalArScmhawnaC,r.tGz.m,aCnarRlesacotni,onR.. P.P,roBcreoewdni,ngWs.ofR.thaenSdocIitektiynAf,.o:r EIxnpdeormiemtehnatcailnBIinohliobigtysatnhde Medicine, 134(1): 163-168 (1870) 25. Whitlock, R. Veterinarian LHI.X(a4n):d B5r1o5w-n5,24W.(19R6.:9)C.hronic Cholangiohepatits in the Dairy Cow. Comell 26. Brown, disease. W.DerR.,TiKerrozoku,chLt.2e0ar:nd54P6o-n6d4,7 W. G.: (1968). Atrophic Rhinitis in Swine. A nutritional vo . 27. Scott, M. L., Myocardium Olson, G., Krook, L.Brown, and of Smooth Muscle in the W. R.: Young PoSuellt.enJiouumr-nraelspoofnNsuitvietiMoyno9p1a(t4h)i:es73o-f . 583 (1967). 28. aBnrodwPnr,opWh.ylaR.x, isK.roCookmLe.l, lPoVnetde,riWn.arG.i:anALtVrIo,phSiucppRhlienmiteinstinNoS.wi1n,e.1-E1t2i8ol(o1g9y6,6)P.athogenesis. 29. Brown, W. Veterinary PRr,a,ctKircoeo4k7,(9L.):a3n9d-4P5,onAdu,guWs.t G., A 1966. New Look at trophic Rhinitis. Modern 30. Krook, L., Pond, Alrophic Rhinitis. W. G. and I. Nutrition. Brown, W. Proceedings R.: of Dietary Calcium and Phosphorus and the 57 Annual Meeting of the American Societyfor Animal Science. J. Animal Science 24: 892 (1865) 31. APtornodp.hiWc.RhGin.i,tisK.rookP,rocL.eeadnindgsBrfoowrn,theW.19R6.5: Dietary Comell Calcium and Phosphorus and Nutrition Conference for Feed Manufacturers. Buffalo, New York (1965). BookChapter . 1. BChrroownni,cWR.atR.B,ioIampslsiacyatiinon"sBiooflotghiecaRleBeaxsaimsinfoartiRoinskofAstsheesLsimveerntSeocftiDoinosxifnrsomantdheReTlCatDeDd CC.omA.po(uenddss),",CoBladnSbpurriyngReHpaorrbtor35L,aGbaolrlaot,orMy. A., Scheuplein, Press, 1981, pp. R. J., 13-25. and van der Heijden, WR 8 W.Ray sof DUM, PhD Veterinary Pathologist Mea 11 200 Date 45 1 June 2003 . CURRICULUM VITAE Name: E3m0e2s8t EE.thMacCnoLnanneell, DVM, MS (Path) : Raleigh, NC 27613 DPatel & aocfBie rth:OrNrovivlelem,beOhri1o4,1937 A Citizenship: United States Education: cl . 11995557 -- 11996517 -- DPr.eVv.eMt,erTihnearOyhMieodiSctiantee,UnTihveerOshiitoy State University 11996654 -- 11996676 -- RM.eSs.i,deDnetp,aVrettmeernitnoafrPyaPtahtohloolgoyg,y DMiivcihsiigona,nASrtamteedUniFvoerrcseistyInstitute of Pathology, Washington, DC Board Certification: DDiipplloommaattee,, AAmmeerriiccaann CBoolalredgeooffTVoextiecroliongayr,y1P9at8h0ologists, 1968 `CBriehf ronooflEmpolovgmenyt: Jun 1961 - Aug 1961 Small Animal Practitioner, Becker Small Animal Hospital, Columbus, OH Aug 1961 - Aug 1961 First Lieutenant, US. Air Force, Gunter AFB, MontgomeryA,l Oct 1961-Sep 1964 Base Veterinarian, Hill Air Force Base, Ogden, UT LanSsienpg,19M6I4 - Sep 1965 Graduate Student, Department of Pathology, Michigan State University, East Sep 1965 - Oct 1967 R`eWsaisdheinntg,tVoent,eDriCnary Pathology Division, Armed Forces Institute of Pathology, PathOocltog1y9,67 - May 1969 Veterinary Pathologist, Aerospace Pathology Branch, Armed Forces Institute of Washington, DC May 1969 Research - Aug 1972 VPeattehroilnoagryy, PWaatshholionggitsotn,,GDeoCgrwaipthhidcutPyatihnoltohgeyPDaitvhioslioogny, ADerpmaerdtmFeonrtc,esVeItnesrtiintaurtye.of Institute, Onderstepoort, Republic of South Africa 46 Lab.Aug 1972 - Aug 1974 Chicf, Pathology Branch, Toxic Hazard.s Div., 6570 Aerospace Medical Rescarch . `Wright-Patterson AFB, OH PuthAoulgogi1s9t74an- dNov 1978 Veterinary Pathologist (Grade 03), U.S. Public Health Service, Research Head, Comparative Pathology Section, National Institute of Environmental Health . Sciences (NIEHS), Research Triangle Park, NC. Nov 1978 - Jan 1984 VeterinaryDirector (Grade 0G), NIEHS, Chicf, ChemicalPathology Branch, Toxicology . Research and Testing Program, Research Triangle Park, NC Sep 1983 - Jan 1985 VeTteesrtiinnagrPyrDoigrreacmt,orRe(sGreaadrech06T)r.iaNnIgEleHSP,arAkc,tiNnCg Director, Toxicology Research and Jan 1985 - Oct 1988 Veterinary Director (Grade 0G). NIEHS, Director, Divisionof Toxicology Research " and . . Testing Program, Research Triangle Park, NC ` Oct 1988 - present President, ToxPath, Inc., 3028 Ethan Lang, Raleigh, NC MilitaryService: ! AAuugg 11906714-- AOcutg1190878:4: UU .S. APSuibrlFioc.rHceealth Service CurrentSociety Memberships: A``AmAmemeerrriiicccaaannn VACeostlselorecigineaatorifyonVMeeftdoerirciranhlaerAAysdsPvaoardnhaoctleiomogeinsntts of Science American Board of Toxicology American Registry of Pathology, AFIP NCoormtmhisCsarioolnienda COhffaipcteerrs oAfsstohceiaStoicoine,ty1o1.f5.TPouxbilcioclHoegaylth Service . SSoocciieettyy ooff TTooxxiiccoollooggiyc Pathologists Charter Member, Alumni Society, Armed Forces Inst. of Pathology Honors & Special Scientific Recognition: Distinguished Citizens Award, Hill AFB, Utah, 1964 National Defense Service Medal, 1967 presUAeSdn.jtuAnicrtFAosrscoeciMaetreitPorroifoeusssoSre,rvSiccheooMledoafl,VeWtreirgihnta-rPyatMteedricsionneA,FNBo,rOthhioC,ar1o9li7n4a State University, U.S. Public Health Service Commendation Medal, NIH, Washington, DC, 1978 Study Section-Agent Orange, Veterans Administration, June 1982 ResCcharacihrman, Natural Exposure Study of Animals in Environmental Health Rescarch Workshop, Council, National Academy of Sciences, April 1985 1978 to National 47 NewPUaaSrn.kc,lPiuNsbtel-wiScpeHaekaelrt,hCOountfsetraenndciengonSetrhveicIempMleidcaalt,ioNnIsH,ofWatshehiBnhgotpoanl,TDrCa,ge1d9y,85The Workers Policy Project, ' PTaansJceklrsFMeoeyr,mcbeMeaLrre,cadhIeAr1R,9C8S5tWuodrykiofngChGermnoiucpalonTrtahcekiEnvaglAugateinotn(oNfPPtDh)e CuasrecdinboygetnhiecSRoivsiketofKGCBh,emMiocsacloswt,o1985 HumaSnosm=e Chemicals Used in Plastics and Elastomers, Lyon, France, June 1985 BSotaurddy MDiermebcetorr,fAomretrhiecNanTPBoMaertdhyolfITsooxciycaonlaotgey,St1u9d8y5,-11998850 . PPaanncell MMeemmbbeerr,, RIeAfRrCacWtoorrkyiCnegraGmriocupFiobnertAhneiEmvaalluSattuidoineso,fTtIhMeAC,ar1c9i8n6ogenie RiskofChemica- ls to Humanansd- SSiolmicea Silicates, Lyon, France, June 1956 CanPcaenrelRiMsekmsber, DHHS Comittee to Coordinate Environmental and Related Progr; ams "Report on PreAssidseoncti,atAemdewriitchanthBeoIanrgdeosftiToonxoifcoAlsobgeys,to1s9"8,7-1198978.8 - . LonPdaonne,lEMnegmlabreird,, Health Consequences of Occupational Exposure to Man-Made Mineral Fibers, TIA, PanJealnuMaermybe1r9,87JARC Working Grou (0 update IARC Monographs: Chemicals and Industrial Processes Associ`aCtanecderwiitnhHumans, Lyon, France, March 1987 P`VainceelCMheamibremran/,RaJpApRoCraWtoeruksi,ngIPGCrSo/uMpAoRnCMTaans-kMGardoeuMpiMneeerta]inFgiboenrsMaannd-MRaaddeonM,inLeyroanl, FFirbaenrcse,,LJounndeo,n1,987 EnglanSde,ptember 1987 PDainsetlinMgeumisbheerd,ANlautminonuasl,RCeoslclaergcehoCfoVuentceirli,nBaoryarMdedoinciEnnev,iTrohnemOehnitoalStSattuediUenisvaernsditTyo,xiJcuonleo,gy1,988 Subco"mAmniitmtaelesoans Monitors of Environmental Hazards", 1987-1989 : CCoon-sCuhlatiarnmta,n,SARBev(iDerriwnokfinEgPAWatCearncCeormAmsistetsesemeanntd EGunivdierloinnmees,nt1a9l8H8e-a1l9t8h9Committ|ee, Environmental Protec1t9i8o8n.Agency, Member, Conunitee on Toxicology, National Research Council, B; oardon Environmental Studies on Toxico1lo9g9y.,1994. PLeacntculreMre,mBbreorok(iandgshoIcn)s,tEitPuAt-eF,I1F9R8A9Scientific Advisory Pancl, 1989 DecPeamnbeelrM,e1m9b9e1r/Rapporateus, IPCS/MARK Task Group Meeting on Benzene, Hannover, Germany, FPaDnAclGMreomubpeRre,coEgPnAi-tFiIoFnRAAwSacride,miNfiitcroAfduvriasnorHyeaParnienlg,T1e0a9m2,-21090902. 199P2a.nel Member, IPCS Task Group Meeting on Synthetic Organic Fibers, London, England, September, thePancl Member, WHO European Programme for Occupational Health, "Validity of Methods for Assessing ChaCiarrcmianno,geEnPiAc-iFtIyFoRfAMSacine-nMtiafdiec AFdivbeirsso"r,yCPopaenn,ha1ge9n9,3Denmark, 1992 Member, EPA Science Advisory Board Executive Committee, 1993-1999 48 PPaanneell MMeemmbbeerr/,REapPpAorScaiteenucse,AIdvPiCsSo/rMyABRoKarTdu,sDkioGxrionuRpeMveieetwinCgomomnitPhtoeseg(eHneea,lLtohnPdanoenl,),En1g0l9a5nd, March, 199P6a.nel Member, [PCS/. MARK Task Group Meeting on Chloroethers, London, England, March, 1996. "ToxPiacnocllogMiecmablearn,dNational Research Council, Commission on Life Sciences, Subcommittee on PanPcelrfMoermmbaenrc,eEAPsApeScctisenotiffiOcsyAgdveinsaotreydBMooatrodr, CVeohmimcilettFeuelo"n,En1v9i9r6onmental Health, Ad Hoc member for PonNeelurMteomxbiecro,loEgPyAGuFiodoeldinQeusa;liCthyaPirro-teTchtyiroonidAcCtarAcdivniosgoernyesBiosarGdu,id1e9l9in6es, 1996 PMaenmebleMre,mIbLeSIr,RiEsPkAScSiceinecneceInAsdtviitustoeryWoBrokairdn,gEGPrAouPproopnosDeodseGuSiedleelctiinoens,f1or09C6arcinogenic Risk AssPeasnsemleMnte,mb1e9r9,7 IPCS Workshop on Issues in Cancer Risk Assessment. Hannover, Germany, January 1008 and January, 1999. 1999`.CoChair, EPA SAB/SAP Joint Meeting "Testing of Pesticides in HumanSubjects',|Dec 1998 and Nov CoCr, EPA SAB/SAP Joint Meeting `Endocrine Disruptor', March 1999. ' `. thePUaSncl Member, National Research Council, Commission on Life Sciences, Subcommittee on "Review of. . InvNiatveyd'EsxEpxerptosTuersetiLmiomintysofnorTMriacnhulfoarcotetuhryeldenVei,trAeuosutsraFliibaenrsS"o,li1c9i9to9r-2Ge0n0e0r.al, Mlbourne, Australia, Nov. 199P9a.nel Member, International Conference of the World Health Organization. "Advancing Knowledge on ModReergautloart,in2g0T0o0baSocceioetPyroodfuTcotxsi"c,oOlsolgoy, N"Iosrswuae"y,SeFsesbirouna,ry",Th2e00V0a.lue and Erbics of Using Human Data for the Registration of Pesticides", Philadelphia, PA, March 2000. April Cha2i0r0,1R.eview of the Toxicology Program, Lovelace Respiratory Research Institute, Albequerque, NM, PRSoespspiaotnoCwh,aiLr,SRiAsgkriAcsulsteusrsamleCnhteMweitchaodSso,fe"2y0A0s1sAessbmeesntto,s HWeoarlktghzEofufpec#t1s,CAopnfee,re2n0c0e1", Oakland, CA, MayMe2m0b01e.r, Lovelace Respiratory Research Institute's "Research Programs Oversight Committee', 2002- FibeMremLebnegrt,h.ATSDR Expert Panel on Health Effects of Asbestos and Synthetic Fibers (SVE: The Influence o:f TesNteiwmoYnoyrkb,efNoYr.e2N9R-3C0/NOcAtSobCeormm2i00t2t.ee on the UseofThird Party Toxicity Research with Human Resear`WcahsPhairntgitcoinp,anDtCs.. 19 March 2003. witMheTmabceorni,teInatenrdnatthieonal Symposium on the Health Hazard Evaluation of Fibrous Particles Associated MemAdbjearc,eEnPtADAuslbuethstCoosmpMleecxh.anisms of Toxicity Workshop, Chicago, IL. 12-13 June 2003. ChaiCro,ntSaumbicnoemnmtis.tteNaetioonnaElmeArcgaednecmyyaonfdSCcioenntciens.uo2u0s0E3x-p2o0s0u5.re Guidance Levels for Selected Submarine Member, ILST HES] Technical Committee on Agricultural Cemical Safety Assessment. 2003-2004. Editorial Boards: 49 MEeadviicraolmmReenstcaalrcHheaClotuhncPielrsopefcCtainveasd,a,1918938-21-0190084 DFurnudgaamnedntCahlemaincdalApTpolxiiecdolToogxyi,co1l9o8g6y-,11999849-1995 Inhalation Toxicology, 1995- - Reviewer: i Science ATonxniaclosloogficOaclcuSpcaiteinocensal Hygiene . Bupers Published: 1. McConnell, EE: Case for diagnosis. Yaba monkey virus.MilitaryMedicine 1324838, 869, 1967. 21.968M.cConnell, EE: Garner, FM. and Kirk, JH: Hartmanellosisn a bull. PathologiaVeterinaria 5:1-6, I3.AVMcMCAon1n5e6l:l1,97E-E2,03C,as1h9e7l0,. LG. and Garner, EAL: Visceral leishmaniasis with ocular involvement in a dog. m4.ucMocsCaononfelals,hEeEe,poVfapnosRseinbslbeurign,feLctBi.ouasnodriVgainn.LWASyk.,fL.A:rAViecta.sec Moefd,a aAdsesnnoocc.ar4c1i:n9-o1m2a,o1f9t7h0e. olfactory A5.ssVoca,n4R1e:n7s6b,u1r9g7,01.8. Roos, C.J. and McConnell, EE: Diverticulosisin a cow.LAS.friVocr,aMend, VG.etB.osMmeda,nA,ssP.oPc.,. M4c1C1o3n4n,el1l9,70E.E. and Schutte, A.P.: Bovine abortion caused by Aspergillus sp..LS.African 7. McConnell, EE. and Tustin, R.C.: Pancreatic calcult in @ cow. LAS. frVi er,Mced,aAssnoc. 41352, 1970, C8.haMccmCoanbnealblo,oEnEP,apDieovuorss,inAu.sJ,(BKearsrs,on1,97P2.)A..1andPrdoteoVzooso,l,V.:18I:s28o-p3o2r,a 1p9a71p.ionins. sp. (Emeriidac) of the p9.oiMsconCionngn.ell,LS. EAEf.fiVcaannVReet.nsMboudr,g,As1sBoc..a4n2d:8M1i-n8n4e,,1J9A71:. A rapid fest for the diagnosis of strychnine D1i0.geMsctC2on:n2e0l.l3,4,EE1:971Foot and mouth discase in South Africa - Reportof the 1969 outbreak.AFMed.Serv. A41s.soMc.cC4o2n:n1e8l9l19E1E,. 1S9mi7t1, 1.D. and Venter, K.J.: Melanoma in the larynxof a dog. LAS.friVcet,aMend, r1e2p.oSrtc.huLtASte.,fAP.,rMcVCieotn.nceMleld,.aEAEs.snoacn.d4B2o(3s)m:a2n2,3-P2.2P6:, V1i9b7r1i.onic abortion in wes in South Africa: Preliminary Y1e3t., MRceCso.n3n8e2l1l1E1L7E,12B6a,sso19n7P1.A. and Pinaar, .G.: Prewmocystosis ian domestic goat. Onderstepoor1t. 50 (1A4c.aCroifnfae:eH,aGloMr.acVhnaindaAcs)weagnedn,a nPeLMw.r,ecMocrCdonfnreolml,thEeE.ChanadcmBaasbsaobno,oPn..A.:ZDeesciriptFtuiorsofnAncagnewehawnndratseailZomoifltoegtic: *SBRN185190,1971. K1e5r.r,Mc1C9o7n2n).ellO,nEdE,eBrasssotne,|Pp-VAoe.to.anRrdetsd.e1V8o:s2,0V7;-21N4a,sa1l97a1ca.riasis in the Chaczna baboon (Papio ursinus, f16r.omCotfhfeeel,arGyMn.geaalndveMntcrCiocnlneeslolf, tEhEe:ChPancoaruamobnaybsosouns(vPoacpailoisurns. isnpu.s,(AKcearrri)n.a:ZHealairatchsnFiudcracah)ngarenwieawnfdmtittee Zoologge 58:265-270, 1971. u1r7s.iBnaurst,scKhe,rrR,C1.9,7W2e)s.sLeAalblnsi, mB.aC.lasnd6:M4c1C-o1n7n,e1ll0,72LE: Myocardial tuberculoma in a Chacma baboon (Papio 6178.8-M6c8C2o,nn19e7l2,.EE, Basson, PA. and deVos, V.: Laryngeal dcarasis in the Chiacma baboon. JAVMA 161: K19r.ugMecrCoNnanteiloln,alEPEa.rkT.usLtSi.n,AfRr.iCc.aann.Vdedre.VMose,d.VA.:ssAonct.h4r3a:x18i1n-a1n87A,fr1i9c7a2n.buffalo (Syncerus caffer)in the. `: * 2m0u.scMlceCsononfelclh,acEmEa.bBaabsosoonns,.P.AO..nTdhoemrass,iS.cE1.paVnoedro,dRreeVtso.s,39V:.:11Q3-o1c1y6s,ts1o9f72I.sospora Papionis in the skeletal "2f1r.eeMcrCaonngnienlgl",CEhEa.cmBaasbsaonb,ooPnAs.(PWaoplisotuernshionlumse),fBr., omdetVhoes,KrVu.gearndNaMtailohnearlbeP,arHk..: Trtaonxso.pRl.aSsomco.Tsriosnp, Med, Hig. 67:551-855, 1973. t22h.e dCehVaocsm,aV.b,avbaonoKnic(kPearpti,oCuArWs.iJu.s)afnrdomMctChoennKerlulg,erEEN:atiAonsaulrPvaeryk.of.Ksoeeledcoteed16b:a1c-t1er0i,o1l9o7g3i.cal infections of 2C3o.nfMecrCeonncneeloln, EEnEv:irLoensmieonntsalfoTuonxidcionloagnyi.ma(lAsMReLxIpToRs-e7d3:t1o2c5o)a:l1t8a9r-a1c9r8o,so1l9s7.3.Proceedings of 4th Annual f24r.eeM-crCaonnginnegllb,abEoEo.nsBa(sPsaopni,o PurAs,inducsV)ofs,roVm.,tMhyeeKrrsu,gBeJr. NaantdioKnuanlizPa,rkR.E:OnA dsuervreysotf adIi,psVeeoars.oeRsreastm.o4n1:g971-01068, 1974. e25x.poMsaucrEewsetno,hJy.dDr.aMzciCnoenonenlaln,imEaEl.s.anPdroBcaecekd,iKn.gC.s: 5ThheAnenfufaecltsCoonff6e-rmeonnctehonchErnovniicrolnomwenltevaellTionxhiacloaltoigoyn. AMRLTR-74:123:225-235. 1974. 2o6c.cuHlatrrdiiss,eaAsMe.inHaorrteosne,arMc.hLc,aLneitnsechceorl,onRyM..,LMacb.CoLninb,elAln,imE.ES.cia.nd24N7e6w9,7A9E9., 1E9n7z4o.otic Brucella canis - an 2S7t.reSpttuoacrto,cdD.DL.abB.uAckn,imG..ES.cia.nd25M:c2C0o6n-n3e0l2l,,1E97E5:, Necrotic dermatitis of mice caused by Lancefield Group G. i2n8h.aMlcatNiuotnt,exNpS.o,suArmestioer, RI. McConnel, EE. and Morris, F.. Hepatic pathology in mice after continuous 1.1.1 trichloroethylene. Lab, Invest. 32:642-654, AMRLTR74-60, 1975. 51 29. Thigpen, ).E., Faith, RE. McConnell, EE. and Moore, JA: Increased susceptibility to bacterial infection as a sequela of exposure to2,3,7 8-tetrachlorodibenzo-p-dioxin. Infect.Immun. 12:1319-1324, 1975. a30n.imMaclCso.nVneerl,lP,aEtEh.. a1n4d:4T3a5l-l4e4y,0,FA16:77.Intracytoplasmic hyaline globules in the adrenal medullaof laboratory 31. McConnell, EE: Parasitic discascs observed in free-ranging and captive baboons. Comp.Path,Bull. 0(3):3, 1977. 1978. . 32. McConnell, EE., Moore, J.A. and Dalgard, D.W.: Toxicityof2,3,7 8-tetrachlorodibenzo-p-dioxin (TCDD) in rhesus monkeys (Macaca mulatta) following a single oral dose. ToxApiplc .Phoarmlaco.l. 43:175-187, `33p.relHiamsisn,arJyR.r,epMocrCto.nLnellAg,r.EEF.ooadndChHeamr.va2n6,:D0.4J:.0:0,Ch1e7m6ic.al and toxicologic evaluation .of Fircmaster BP-G: a 34. McConnell, EE., Moore, ].A., Haseman, J.K. and Harris, MW. The comparative toxicity of chlorinated dibenzo-p-dioxins in mice and guinea pigs. ToApx pl.i Pharc mac. ol. 44:335-356, 1978. "35. McConnell EE, Hass JR.. Altman, NH. and Moore, JA: A spontancous outbreak of polychlorinated b2i6p(h5e6n6y6l-(6P7C3B,) t1o9x7i9c.ity in thesus monkeys (Macaca mulatta): toxicopathology.Lab,Anim. Sci. 20051661665, 1979. ' 36. Alrman, N-H., New, A.E., McConnell, EE. and Ferrell, T.L: A spontaneous outbreak ofpolychlorinated biphenyl (PCB) toxicity in rhesus monkeys (Macaca mulatta): clinical observations.Lab.Anim.Sci. 37. McConnell, E.E., Wilson, R. and Moore, J.A.: Dose response of 1,2-dimethylhydrazine and methylazoxymethanol acetate in the F344 rat.CancerLetters 8:271-278, 1980. 38. Van Logten, M.J., Gupta, B.N., McConnell, EE. and Moore, JA: Role of endocrine systemin the action of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the thymus. Toxicology 15:135-144, 1080. 39. Fowler, B.A., Kimmel, C.A., Woods, 1.5., McConnell, EE. and Grant, LD.: Chronic low-level lead toxicity in the rat. II. An integrated approach to the assessment of long-term lead toxicity. Toxicol.Appl. Pharmacol. 56:59-77. 1980. . 40. McConnell, EE., Moore, J.A., Gupta, BN,, Rakes, A.J., Luster, M.I, Goldstein, J.A., Haseman, JX. and PCalrikneirc,opCat.hEo:loTghy.e cThroonicxtAoxpiipclic.tyPhoofrmtlaeccho.nli.ca5l2a:n4d68a-n4a9l0y,ti1ca9l80p.entachlorophenionl cattle. L 41. Parker, C.E., Jones, W.A., Matthews, H.B., McConnell, E.E. and Hass, J.R. The chronic toxicity of technical and analytical pentachlorophenol in cattle. 1. ToxAi pplc .Pho armlaco.l. 55:359-369, 1980. 4ra2b.biMtes.ReLc,MDi1c,roFwaiatvhe, RP.owaenrd M15c(C1o)n4n5e-l5l2,,E1E9:80.Effectsof long-term 2450 MH2 microwave radiation on 1980, 43. McConnell, E.E., Harris, M.W. and Moore, J.A.: The lack of effectiveness of activated charcoal and cholestyramine in reducing the body burden of polybrominated biphenyls. DrugChom.Tox. 3(3):277-292, 52 4142.-dSichmieltlehry,lCh.yM.d,raCzuirnlee.yC,aWn.cH.eraLnedttNeerCson1n1e:l7l5,:7E9E,.198I0n.duction of| colontumors by a single oral dose of 4253.,B7i8rtncbtaruamc,hlLoDr.odDiebceandz,ofGuMra,n Minattthheewwosn,kHeBy.. aTnd oMcCxonAnipeplllc.,PEhoaEr:mlaFcao.tle.o5f7:189-196, 1981. 4a6n.dGmuoputsae,.BNT., oMcCxonAnpieplll.c, PEohEa.rlmHaacr.orlis.,5M7W:9.9-a11n8d,M1o9o8r1.e, JA: Polybrominated biphenyl toxicosis in the rat 4p7h.enLoaxmyb,acJ.iCd.s, iMnarckosm,biTnAa.tiMocnCwointnhe2l,l3,EE7,,5A-bTeCyDwDiicnkCr5am7aB,L/K6.maanldeMmoiocree.,1E.JTAno:sv,Toixircitoy onHftc.hh.lo8r:i8n1a5t-e8d24, i981. 4to8s.icViatny oLfo2g,i3e,n7,8M-.iJ.c,irGaucphtlao,rBoNd.i,beMnczCoo-npnedlilo,kiEnE.(TaCnDdD)Moionrrea,tsJ.AT:oxTihceoliongfylu2e1n:c7e7:o6f8m,a1l9n8u1t.rition on the 49. Dunnick, J.,Prejean, .D., Haseman, JX., Thompson, R.5., Giles, HD. and McConnell, EE: Carcinogenesisbioassay of allyl isothiocyanate. Fund. App.Texicol. 2:114-120, 1981. ' [A 5o0l.dMecnCohnanmesltle,rsE.E:NTNPTTPecThencihcnailcaRlerpeoprotrtNoo.n2t4h9e, cNaIrHciPnuogbelniosciastbiNioona.ss8a4y-2o0f50a,mo1s9i8t3e.asbestos in syrian. t$e1s.tKinlguwoef,pWhtMha,laMtceCoesntneerlsl,anEd.Er,elHautfefd, JcEo.mpHoausncdnsanb,yJtXh.e, NDToPu.glEansv,iJrFo.n,aHnedaMlotohrPeer,sJp.A:45C:a1r2c9i-n1o3g2e,ni1c9i8t2y. h52a.msFteelrdsma(nM,esDo.Bc.r,icMecrCuosnnaculrlat,uEsE).feadndvaKrnyaipnkgal,evJeJl.s oGfrporwottehink.iLdanbey.dAinsicmaasleSacnid. 3l2o(ng0e1v6i1t3y-oGf18s,yr1i9a8n2g.olden `a5A3n.dpD,erxPephwoa,snunRreTec,odlBu.roao6tr8i:mo1an2n0,o-n1G3.cA0a.,n;c1He9ar8s3i,enmdaunct,i|oXn.,byMcaCkonnnoewlnl,caErEc,inBougseenyi,nWr.atasn,dmiMcoeoraen,dJ.hAa:msTtehres.effTeocsticoofla.ge b5i4.phGeunpytla,miB.xN.t,uMricneCothnenrla,t aEnEd.mGooulsdes.iciIn,SiJvAa,noHnatrhries,xpMoWsu.rea.ndTMooorex,AJpApil:. EcPfhfaerocmtascloolfa. 6p8o:l1y-b1r8o,m1i9n8a3t.ed 5m5i.xtGuurpetai,n BtNh.e,raMtcCaonndnemlolu,seE.E,11MoLoirfee,tiJmAe. staunddy.HaTsemoan,xAJpXi.p:lc.EPfhfoaerctmlsaocfa.la.p6o5l:y1b8r-o3m5,in1a9t8e3d.biphenyl . p5r6.ocMecdCuornense.llT,oxEiEco:l,PPaatthhoollo.gyTLr(e1q7u60i-r6e4m,en1t9s83i.n rodent carcinogenasis studies. I. A review of current T5o7x.icMocl.ConPnaetlholl,.E1E1:01P1a6t5h7o6l,og1y98r3equirements in rodent caxcinogenes: is studies. I. Alternative approach. g58o.ldMecnCohnanmesltler,sE.E:NTNPTTPeTcehcnhinciaclaRlerpeoprotrt24o9n, t1h9e83c.arcinogenesis bioassay of chrysotile asbestos in syrian a59m.osMietCeonapseblels,toEsE.anRduttterr, He.Am.,inoUFl3aln4d4i,raBetMs..EannvdriMono,orHee,althJ.A.:PeCrhsrpo.ni5c32e7ff-e4c4t,s o1f98d3i.ctary exposure fo 6a0m.osMictCeonannedllc,hrEyEso.tiSlheefansebre,stAoMs.inRsuysrti,on1Hg.oladnednMhoaomres,ieJrAs:. ECnvhirroonn.icHeefafetchtsPoefrsdpi.e,ta5r3y:1e1x-p2o5s,ur19e83f.o 53 G1. Solleveld, H.A., Haseman, J K. and McConnell, EE.: The natural history ofbodyweight gain, survival and neoplasia in the Fischer 344/N rat. LNatl,CancerInst., 72(4):029-940, 1984. En6svt2r.iurMcoctunKri,enH-neteaoxyli,tchiJP.tDey.r,rseCplh.aate1i,o0n8Ks.4h,iMpcsCfoonrneplolly,chLEl.orainnadteBdirbnibpahuemn,ylLsSa.ndStrreulcattuedrea-rionmdautciticohnyvderroscuasrbons. 6e3x.peSroillmeevnetladl, oH.nAc.ogaennedsMicsC.oTnonxeilclo,l EPEa:thoTlh.e7s2i:g9n2i9fi-c0a4n0c,eo1f9i8n4.terim sacrifice and lifespan data in G4. McConnell, EE, Lucier, G.W., Rumbaugh, R.C., Albro, P.W., Harvan, D.J., Hass, J.R. and Harris, M.W.: Dioxin in soil: Bioavailability after ingestion by rats and guinea pigs. Science 223:1077-1079, 1984. 65. Dunnick, J.X., Davis, W.E., Jorgenson, TA, Rosen, V.J. and McConnell, EE: Subchrohic toxiicnirattsy. administered oral 8-methoxypsoralen. NC atl.anIc nst,e Monor gr. 66:91-95, 1984. * TGGw.o-HyaesaermCaanr,ciJn.Ko.g,eCnriacwitfyorSdt,udDi.eDs.,CHounfdfu,cJtEe,dBaototrhmeaNna,tiGo.An.a,l aTnodxiMccoCloongnyePlrlo,gErEa.m:.1R,esTuolxt,sEfqvriormon8.6Health 14:621-639, 1984. H63i77.s:t1Ho5up4fa-t1fh7,o3l,].oE.,g16yB8a5tR.ees-,cxR.a,mEiunsattiis,onSo..ftHahseemNaant,ioJn.aDl.,CaanncdeMrcICnosntnietultle,'sECEa:rcMianloagtehnieosnisaSntdudMiaelsa.oExnovni:ron,Res. EGn8v.irMocnC.onHneealllt,hEPEe.r:s,Com6p0a:r20a-t3i3v,e 1T9o8xi5city ofPCB's and Related CompoundsinVarious Species of Animals. R6e9.suHlutfsf,inJ.CDa.r,cMicnCoogennnieclilt,y ESFt.u,daineds iHnaAsneimmaanls,.J.KE.a:viLretotnemretnotatlhMeuEtdaigteorneosnitshe7:P4r2o7p-o4r2t8i,o1n9o8f5.Positive 70. Solleveld, H.A., and McConnell, EE.: The Value and Significance of Life Span and Scheduled Termination Data in Long-term Toxicity and Carcinogenesis Studies. Tox.Path. 13;128-134, 1985. CO7a1b.nsceHerarvsIenedsmtiaintnUu,JnteiKr.7i,5aH(t5ue)fd9fa7,5n-d.E9,C8oR4ar,on,19OG8i.5lN..G,avAamgoeldC,onJt.rE.o,lBGoroorumpasn,ofG.AF.3, .a4n4/dN MRcaCtosnannedllB,GECE3:F1NMeiocpel,LasmNsa S7t2.udiMecsC).onnNeTlPl,TEecEh:niTcoaxliRceoploorgty aNon.d 2C0a5r,ci1n9o8g5e.nesis Studiesof Chrysotile Asbestos in F344/N Rats (Feed 7621283389, 1986. 73. McConnell, EE., Solleveld, H.A. and Boorman, G.A.: Guidelines for Combining Neoplasms as Evidence of Carcinogenicity in Long-term Toxicity and Carcinogenesis Studies. 1Natl,CancerInstitute 7N4o.meMnacrloantpuorte, Rf.oRr.,HeMpoanttopgroomleirfeyraJrr.i,vCe.AL.i,siBoonosrmofanR,atsG..A.T,oxM,cCPoatnhn. ell1,4:E2E63:-2N7a3t,io1n9a8l6.Toxicology Program Toxicol.Phunmacol 6155-170, 1086. 75. Haseman,J K., Harrington, EC., Huff, JE, McConnell, EE: Comparison of Site-Specific and Overall Tumor Incidence Analyses for 81 Recent National Toxicology Program Carcinogenicity Studies. Regulatory 54 G76A..McRCiocnhnteerl,l,C.:E_ ET,heBuTcohxeirc,itJyR.o,fSMcehtihwyet]z,IsBo.rAy.anGautpet.aE,nvBiXr.,onS.hSeelibye,ncMeTDe.chLnuostle.r,31M:,18B8r-o1d9y3,,A1R9.8,6.Boorman, F77i.schMecrCo3n.4n1e4l/lN,raEtEs:anNdTBP6TCe3cFh1nimcialcere(pvoratgoenstthuedyc)a.rcNiTnPogTeenceshinsicbailoRaespsoarytofNod.ig2l5y7c,id1yl98r6e.sorcinol etherin T78o.xiBcuicthyeorf,MJeRt.h,ySlchIwseorczya,nBatAe.CSohneflebrye,nMc.eD..EnvMciCroonnn.eHlela,lEthE:PorIsnpt.ro7d2u:c3t,i1o9n8t7o. the Proceedings of the E79n.viMrcoCnomnennetlall, aEnEd,Roeflaalt.e(dPrPerpoagrreadmsb,y SauWbocrokmimnigttGereouopn fRoirskthAessDeHsHsmSenCto)m:miRtetpeoerttoonCoCoarndcienratReisks Associated with the Ingestion of Asbestos.Environ,HealthPersp. 72:253-265, 1987. 80. McConnell, EE: Letter 10 the Editor on Cancer Phobia. Sgience 238:59-60, 1987. C81a.rcHiansogeemnainc,itJyK.S,tuHduifefs,. JEEn.viZreoing.eHr,eEa.lMtchPCeornsnpe.ll7,4:E2E2:9-2C3o5m,pa1r98a7t.ive Resultsof 327 Chemical . 8W2.., HHaurftf,, LJ.EG.,MRcalClo,nDncPl:),CEaErc.iHnoagseenemsains,StJuKd.iBeos:orRmeasnul,tGs.oA.f,3E9u8steisx,peSr.Li,meSncthsweoinz,10B.4A.c,hReamoi,caGlNs.frJoammetsheon, US. National Toxicology Program. inLCivihng ien&micaWorlld. An N.Y.n Acad,a Sci, 534:1-30, 1988. 8c3a.rcHioncolg,enDi.cGi.t,yHsatsuedimeasn:,imJ.pKl.i,cHaotgioanns, fMo.rD.r,isHkufafs,seJs.,smMecnCto.nneClalr,ciEnEo:genTehseisim9p2a0c4t5o-f20t5ox2i,ci1ty98o8n. 8344.3M/cNCroantnsel(lfe,eEdEs:tudNy)T.P NTeTcPhnTieccahlnirceaplorRtepoonrtthNeoc.ar3c3i5n,og1e9n8e8s.is bioassay of crocidolite asbestos in Fischer 815..3-MBeultnaidcikc,neRLb.y tHhueffN,aLtiEo.naHlasTeoxmiacno,lo1.gKy.,PMrcoCgornanme.llA, EnE: CnhArcoan.di.cSt. coixeicn.icteysre5s3u4l:t6s4a8n-6d6o2n,g1o9i8n8g. studics of 86. McConnell, EE: The maximum tolerated dose: The debate. 1. Am.Coll.Toxicol., 6:1115-1120, 1989. r8a7t.sM(cfCeoednnsetuldly).EE:NTNPTTPecThencihcnailcaRleproerpotrNtoo.n2t7h7e. cMaarrccihno1g9e9n0e.sis bioassay of tremolite in Fischer 344/N 8F5i.scMhuerrtFh3y4,4A/nSXin.rMatcsConndnelBlG,CSEFEY. mHuifcfe, eLxEp.osRuesdsftioclddi,glAyBci.dyalnrdesGoorocdi,noAlEe:theFro-rAesnteopmoaxcyh neoplasimns" resin. Food. Chem.Toxic. 28:723-729, 1990. g89o.ldMecnCohnanmesltle,rEsE.(feNedTPstTuedyc)h.niNcTaPl RTeepcohrnticoaln R1ehpeocratrcNion.og2e:n6e,sJiuslybi1o9a9s0s.ay of chrysotile asbestos in Syrian 3904.3M/cNCorantnsel(lfe,edEEs:tudyN)T.P NTeTcPhnTieccahlnirceaplorRteoponrttheNoc.ar2c7i9n,ogNeonveseimsbbeiroa1s9s9a0y. of amosite asbestos in Fischer 931.41MrcatCso.nnIenlhall,atiEonE. HTaolxi,cLol,an3d:3A2d3k-i3n3s7,,B1.A0.9:1Studios on the toxicity (inhalation) of wollastonite in Fischer 9129.01M.cConnell, EE: NTP Carcinogens - Intrerpretational Problems.Exviron,Mutugenesis, 248:233-237, 55 s93t.udMiccCsoonfnetlwlo, gErEa.d,eHsuolflp,JenE,taHcehjliomraonpchiekn,olM.i,nPBeGteCr3sF,IA.mCi.cea.nFduPnedr.siAnpgp,lR,.:ToTxoixcioclo.lo1g7y-5a1n9d-c5a3r2c,in1o9g9e1n.esis. : 94. Torahim, M.A, Bond, G.G., Burke, TA, Cole, P., Dost, F.N., Enterline, P.E., Gough, M. Greenberg, R.S., Heavlipdeernicne, oW.nE.t,heMchCuomnanenllc,arEciEn.ogMeunnicriot,y 1o.Cf.,2S,4w-eDn.bEenrvgi,zoJ.nA..H,eZaalhtmh,PeSrHs.p.an9d6:G2r1a3h-a2m2,2,J.:19W9e1i.ght of the s95t.udMiceCsocnonneldlu,ctEeEd: bTyhtyhreoiNdCIf/oNllTiPc.ulRaergc.elTloxciarccoiln,oPgeinensi,s: 1R6es1u7l-t1s8f8r,om1939423. two-year carcinogenicity 96. Hestexberg, T.W., McConnell, EE, Miller, W.C., Hamilton, R. and Bunn, W.B. Pulmonary toxicitofy inhaled polypropylene fibers in rats. Fund,Anpl.Toxicol, 19:358-366, 1992. 97. Hesterberg, T.W., Miller, W.C., McConnell, EE., Chevalier, J., Hadley, J., Bernstein, DM., Thevenaz, P. and Anderson, R. Chronic inhalation toxicity of size-separated glass fibers in Fischer 344rats.Fund.Appl. Toxicol, 20:464-476, 1993. . 98. McConnell, EE. and Swenberg, J.A. Styrene and styrene oxide: Results of studics on carcinogenicitiny experimental animals. In Butadiene and Styrene: Assessmentof Health Hazards,IARCScientific "Publications, Vol. 127: 323-333. 1993. P9a9t.hMolcoCgoyn,ne2l2l:,14E1E-.1a44n,d E1u9s9t4i.s, S.A. Peer review in carcinogenicity bioassays - Uses/abuses. Toxicologic 20:96-104, 1994. 100. Lucas Luijckx, N.B., Rao, GN., McConnell, EE., Wurtzen, G. and Kroes, RTheintake of chemicals related to age in long-term toxicity studies- Considerations for risk assessment.Reg.Toxicol.Pharmocol., 101. McConnell, EE. Kamstrup, O., Musselman, R., Hesterberg, T.W., Chevalier, J., Miller, W.C. and 3Th4e4v/eNnarazt,s.PI. nChharloantiiconiTnohxaliactoilo,n 6s:t5u7d1y-6o1f4,si1z9c-9s4e.parated rock and slag wool | insulation : fibers in Fischer iR1n0e2hl.aaltaHiteoisnotsnehriibpnebrraegtt,sw.Te.EeWnn.v,iTMruioningll.ebHril,otsWhp.,ePrCe.,srissMptaes,ntc,1e0R2.a,3n1Md3cbC3io1on3ln7oe,glilc1a,9l9E4aE,f.f,ecBtesrnosftemiann,-DmMa.deanvditAineoduesrsAobne,rsR.after chronic 31043,.1M0c0C4o.nnell, EE. Synthetic vitreousfibers - Inhalationstudics. Reg.Toxicol.Pharmogol, 20 (2):522- 102:207-210, 1994. 104. Mast, RW., Hesterberg, T.W., Glass, LR., McConnell, inhalation and biopersistence of refractory ceramic fiber E.E., Anderson, R. and Bernstein, D.M. Chronic in rats and hamsters.Environ.HealthPersp., P1h05a.mocMoclC,onn2e1l3l8-E4E3.,Hi1s9t9o5r.ical revicw of the rodent bioassay and future directions.Reg.Toxicol, 106. McConnell, EL. Mast, RW., Hesterberg, T.W., ChevalierJ,., Kotin, P., GSlyarsisa,n LgRo.ldaenndhaAmnsdteerrsso.nI,nhR.alCahtrioonniTcoxiinchaolla,t7i:o5n0t3o-x5i3c2i,ty1o9f95a.kaolin based Bernstein, refractory D.M., Thevenaz, P., ceramic fiber (RCF) in 56 L10R7,. MMialslte,r,RWA..C.MacnCodnnHeesltlc,rbEeEr,g,ATndWe.rsSornu.diRc.s, Cohnavtahleiecrh,roJn,iKcottionxi,cPi.t,yBienrhnasltaetiino,nD) Mof,fTouhrevteynpaezs,o2f, Glass, * refractory ceramic fiber in male Fischer 344 rats. InhalationToxicol, 7:425-467, 1995. G1l0a8s.s,MaLsRt,, RMWie,rM,cCWo.nnaenldl,AnEdEe,rsHoens,teR.rbAermgu,lTfiWp.l,eCdhoesvealicehrr,onJi.cKionthianl,aPt,ioTnhteovxeinciatyy,sPt.udBeyronfstseiizne,-sDcApLa,rated Kaolin refractory ceramic fiber (RCF) in male Fischer 344 rats.InhalationToxicol. 7:460-502, 1995. 191099.5McConnell, EE. Advantages and linvtations of in vivo screcning tests. Ann. Occup,Hyg, 30:727-735, q1u10a.rtMzc.CQocncnuepl.lE,nEvEi.roFni.bMreogde.nic52e:f6f2ec1t-6o2f4w,o1ll9a9s5t.onite compared with asi bestos dust and dusts containing o1f11v.ieMwc.CIonnhnaellalt,ioEnET.oTxihceoml.ax8i(mSuupmpltio1le1r1a-t1e2d3,do1s9e96i.n particulite inhalation studies:A pathologists point K1a12m.stMrcuCpo,nn0e.l,la,nEdEH,adHleeys,terJ.beRreys,ulTtWs ,ofClhiefvea-ltiiemre,iJn,haTlhaetvioennaszr,udPi.,csKootfing,laPs.s,,Mmaisnte,rRa,l Manudsssellamgawno,olRs, and refractory ceramic fibers in rodents. 1. Occupat.HealthSafety:Australiaand NewZealand. 12:327-332, ~+ =~ * 1996. \ : 1Ob1e3r.dHoersstteerrb,eGr.g,UTs-eW.o,fMlcuCnogntnoexlilc,itEyEa.ndMillulnegr,pWar.tCi.c,leChcelveaalriaenrc,e1,foEveesrtititm,aJt.e, Tthheevmeanxaizz,muPi.aFtleoilsesrnaetre,dHd.oasend (MTD) for a fiber glass chronic inhalation stud in the rat. Fund,Appl.Toxicol.32:31-44, 1996. C1h1a4s.eH,esGtRe.rbaenrgd,TThWe.v,enAaszt,enP,. CC,h,rMocnCiocnninehlall,atEiEo.n Osbteurddyoorfstfeirb,erGg.l,asEsvearnitdt,aJm.,osMiiltleera,sbWe.,stCohseviaalitehre,SJy,riJa.n g`moalddeenFihbarmosutsera:ndTwNeolnv-eimbornoutshpparretlicilmeisn,aLryakreesPulltasc.id,SiNx.tYh. I1n5te-r1n9atSieopntal19C9o6n.fEenrveinrcoen.oHneaNalttuhrPaelrsapn.d Man105:1223-12290, 1997. M11J5.. MToafyte,sJ,DB.,AS.inMgceCr,onAnWel.l,,BErEow,nN,eaLlF,. BJiK.,MeBnrtuonnne,rR,.8J. ,nHdamMiolotroen,,JS.B4.,CSoumlpliavraan,tTivMe,CaPerrctienrosf,esAiCci,tyRyiann, ToSxpircaoglu.e-SDcaiw.l41e:y6R2a-7t6s,of19t9h5e. Polschiorinatcd Biphenyl Mixtures Aroclors 1016, 1242, 1254 and 1260, . O1b16e.rdHresstteerrb,erGg.,UTsWe.o,fMlcuCnogntnoexlilc,itEyEa,ndMillulnerg,paWr.tCi.c,leChcelveaalriaern,ceJ,foEveesrtititm,atJ.e, Tthheevmeanavzi,nPu.,nFlteoilsesrnaetre,dHd.oasned (MTD) fora fiber glass chronic inhalation study in the rar. Fund. Appl. Toxicol. 3231-44. 1996. P1.17a.ndHeOsbteerrdboerrsyi,eTr:,W.G., ASxttuedni,esC,onMctChoenninehlall,atEiEo.n Htaorxti,coGl.oAg.y, Moiflwleor,bWe.,rgClhaesvasleisera,nJd. aEmvoersiittt,eJa.sbTehsetvoesnaizn, thhealSyrTioxaincoglo,ld1e1n:7H4a7m-s7t8e4r,. P1a9r9t9.1. Results ofa subchronic study and dose selection for a chronic study. G11R8.. MTchCeovnenneazllaEnEd,KoAtxitne,nP,. C.,StHuedsiteesrobnertyh,eTiWn.halCahteivoanliteorx,icJ.oloMgilyloefr,tWw.,o fEivbeerirtgtl,asJs.eOsbaenrddoarmsotseri,teG., Chase, a1s99b0e.stos in the Syrian golden hamster. Part 2. Results of chronic exposure.Inhal,Toxicol, 11:785-836, 57 41109.viMrcusCoinnnSeylrli,anEEg.oladnednChaarmbsotneer,s.MI.nhAalcaotmipoanrTiosxoincoolf,p1l2e:u1r7a3l-m1e8s1o,t2h0e0l0i,omas induced by asbestos and SV- 120. McConnell, EE. Toxicol.Pharmicol, 3A2:s1c4i-e2n1c,e-2b0a0s0e.d paradigm for the classification of synthetic vitreoi us fibers. Reg. ca1as2r1sc.eisnMsoamgseetnn,itRciWotf.y.tohVfeur,MeTgC.rDPa.c,atnOahdreyricdmepolrrisactmaeitrci,ofniG.sbf,eroMricnCrofinsnokealcslhs,reoEsnEsim.ceFnaitns.dcIhUnetheralll3,a:t4MiJoT.natTAoixnrihecatalralot.sip1oe2nc:ts1it1vu4ed1ir-ces1v:1i7Ae2wn,o2f0t0h0e. TC1o2h2xr.iocnFoirlceeN5me3ua:rn3o7,t7oG-x3Bi9c,1i,tSyi2n0go0ef0r.A,rAoWcl.o,r LMoirsdtou,rRes.AA,dPmeitneirsst,eAr.eCd, iNneDali,gtB.foH,SpMrcaCognunee-lDla,wlEeEy,Raatnsd. FMuayneds.,ApBpAl.. 123. Kamstrup, O., Ellenhiuge, A, Chevalier, J, Davis, JM.G. McConnell, EEandTheveuz, P. Chronic inhalation studies of two types of stone wool fibers in rats. InhalationToxicol. 13:603-622, 2001. . v1i2t4r.eoMuasxifiinb,erLsD;.AawnodigMhctC-oofn-ntehlel-,cvEiEd.enIcnteearpsppercoiaecsh.cRoomgp.arTiosxiocnoslo,Pfhtahremtaocxoilci,ty33o1f-a2s4b,es2t0o0s1.and- synthetic 112558.1M2c0C0o1n.nell, EE. The value of human testing of pesticides. HEumcan oandlogiRisckAasselss, 7:1575- m12e6t.hoMdc. CInohnalnaetilEolnE,T.oaxnidcoJl.M..1C.4:1D0av1i-s1.10Q,ua2n0t0i2f.icationof Rbrosis in the lungs ofratsusing amorphometric PParpeerpsairnation/Submitted/AcceptedPr/eIsns GWreaiyg,htGMof,thCeoheevni,de1.nT.c,e Cevuanlhuaa,tiG.o,nHoufglhoews-,doCs.,eMrceCpornondeulclt,ivEeEa,ndRhdoervbeelro,pmLe,ntSiaplese,ffLeGc.tsaonfdBMiastpthiesnoonl, DA.. 11.95M6cC-o1n9n6a5ll(,ThEeEs:is-A1s9t6u5d)y of 76 canine hemangiosarcomas recorded at Michigan State University from 2. McConnell, EE: Yaba virus tumors. National Cancer Institute Monograph 32:239-224, 1969. 73:3D6i:a37m.on1d9,73$5. and McConacl, EE. Veterinary pathology in toxicology research. AFMed.Sve,Dig. w4.ilBdaratnsdchd,oRm.Ce.,stiMccCaonninmeallls,aEnEd. mTaine.s,VGer.,D.PaatnhdolS.ch1un4i3d1r,49L2M4., 1A0r7e7view of exertional rhabdomyolysisn T$1.9C7DM8cD.C.onMniellanlo.,EIEt.alya,ndOcMtooobreer,1J9A76:, TChhaepttoexric13o,paptph.ol1o3g7y-o1f41T.CDSDp.ectInr:umF.PCuabtltiacabteinoins(e,d.H)oPlroics.woWoodr.kNsYh,op on A6.caMdc.CoSnani.el3l2,0:E1E.58a-1n3d0,Mo19o7r91e, J.A.: Toxicapathology characteristics of the halogenated aromatics. Ann. NY 58 7. Moore,J A., McConnell, EE. Dalgard, D.W. and Harris, MW. Comparative toxicity of halogenated + dibenzofurans. Ann.Ny Acad.Sci. 320:151-163, 1079. `8muMtcaCgoennenseilsl., EInE::R.AcKuitmebraonudgchhr(oendi)cHatloxoigceitnya,tceadrBdinpohgeennyelssi,s,Terrepphreondyucltsi,oNne,phttehraalteongeesne,sDiisbaenndzodioxins andRelatedCompounds. Elsevier North Holland, pp. 109-130, 1980. F9r.eMi,cKE.inMneeryia,nJ,. Fa.nPdocMcchCioanrin,el(le,dsE)EC:hloSrtiruncattuerdaDlisopxeicnifsiacintdy aRenldattehde dCiooxmipnoreucnopdt-sorI.mpIna:ct0.onHutthzeinger, RW. Environment. Pergamon Press, New York, pp. 367-381, 1082. . d1a0.taHuofvfa,luLaEt,ioHnatseecmhanni,quJeXs. aMncdCothnenelloln,gtEEe.rmancdarMcoionroeg,enJeAsi:s bTihoeasNsaatyi.onPal rToxoicocloogeyfPterhoegdSryammi,potnsoixiugcmoolsongy SE afetvy alu ofDa rugstandiCheomicanls. Iowa State University, Ames, LA, June 1981. a11n.dMccaCrocninneolgle,niEcE.e,ffWeactgsneorf,UJI.CCC, SCkaindamdoiraen,cJhWr.ysoatnidleMBooarseb,esJtAo:s aAndcogmlpasasramtiicvreofsitburdeyOoMf t1h0e0)f.iJbr:ogenic++ * Biological Effects ofMan-madeMineralFibres. World Health Organization, 1984, pp. 234-252. . 12. McConnell, EE: Comparative toxicity of PCBs and related compoundins various species of animals. Hydrocarbons. National Institute of Ensiroumental Health Sciences and Finland. 1084. d1i3b.eMnczCoo-np-ndeilolx,inE.E:In:ThMe. cKlianmiiconpa(tehdo)loDgic ichainongteshxeinEnvivariiroonunsmessnptec.ieHseomfisapnihmearlesPcuabulsiesdhibnyg Corp., pp. 225.230, 1985. BM 1i4o.loMegciCcoac nlnelhl, EaE: nCloifniiDcioopsaxtihnomAlcotgis iocnC.onpcpep2t7s-3o7f, D1i9b8e4,nzo-p-dioxin Intoxication. In:BanburyReport18: CQ15ac.rtcoMibcneCorogne3n0ne,els3l1i,,s ETaEens:dtiNInsogsvuaeenmsdbReEavriaLsleuadtbi1oy9n84.t.heIUnnN:iaPvtreioroscnicatleydTioonfxgiCsaclooilffoo1gr5yntiPahr,CoIogrnvrifanemer,AeWdnrciHegoohctn-PEPaanntvetilerroosnnomnCeAhnietrmailFcoTarolcxeicBoalseo,gy Ohio, AFAMRLTR 84-002, pp 136-143, 1985. Q16u.alBitoyoramsasnu.raGn.cAe.,iMnopnattghoomleogryy,foCr.Ar.o,dJern,tEcuasrtciis,noSgLen.icWiotlyfes,tuMd.iJc.s.McICno:nnHell,aEEn , oafnddCaHrab crdiinsoo tgye,nJo TFe:stking* (HA. Milman and EX. Weisburger, eds.), pp. 345-357, 1985. Q17. uMcCaoonflnTeolxili,ctEolEo:ygyQSutauldiitcys.indPrtihneceNtaotnioSncailenTtiofxiiccoPlubolgiysPhrionggrCaom..InIcn:.Mpapna9g-1i2n,g1C9o8n6.ductandData R1.8:. MToexnincoclaorgJ,ic, aMnadroCnaprocti,noR.geBnoiocrEmffaenc,tsG.,ofEuIsnthiasl,ed.T,eHtruafcfh,Jl.oHraocstehmyalenn,eJi.n MRcaCtosnanneldlM,icE.e,.RaPgraonc,eeH,diMniglsleorf, Stchiee4ntche IPnutbelrinsahteirosnaBl.YC.o(nBgiroemsesdiocnalToDixviicsoiloong)y,.pIpn:2N0De1-w2e 1C0o,nv c1e98p6te.sinld opmeinnToxitcolosgy,Elsevier T19o.xiHcuoflfo,gJyED,arHaasEevmalauna.tiJ.o,n MTcecChonninqeulels,, EaEnd. LaonndgM-oToerrem,C1a.4r.cinTohgeenNeastiisonSatludTioexsi.coInl:ogSyafPertoygrEavmal,uation of Drinu dChegmicasls, L086. Llyod, W.E. cd, Hemisphere Publishing Company, Washington, D.C., 487 pages, 59 . M2c0.CoLnenrenlenl,, RE.E,.BeMcekiinnhga,rGd.rC,.,T.C,anMltloeri,tKe,, CJRh.eePart,el,J Y.,4, SCoonridlceh,-mF.u,liGrno,tCh., aD.n,dKTeolllelre,fsCo.n,,LLybaRregpeorr,tJ.on Cancer Risks Associated with the ingestion of Asbestos. Environ.HealthPersp, 72:253-265, 1987. 2C1.W.HuHfafr,tJ,EL.G.McaCnondneRlalll,, EDEP,:HaCasrecmianno,geJnXe.siBsoSotrumdaicns,RGe.sAu.,ltEsusotfis3,98SLE.xpSecrhiwmeetnzt,sBo.nA.1R0a4oC,hGeNmi.caJlasmefsroonm, tChheem1i5c.alNaWtoirolnda,)"TNo.xYi.coAclaodg.y PScrio.gr5a3m-4. P1r-o3c0,ee1d9i88n.gsoftheCollegiumRamazziniConferenceon"Livingind 22. McConnell, EE: Mouse `Species Comparisons, Alan liver tumors: the R. Liss, Inc., New Yporrokb,leNmY., 1L:n3:M, o19u9s0.eLiverCarcinogenesis:Mechanisms and 23Pr.esEsl,weNlel,tMYRo.rka,nNdY,Mc19C9o0.nnelElE,:Small and large intestine. In:PathologyoftheFische;rRat, Academic 24. Hesterberg, TW. Vu,V. McConncll,EE, Bunn, Wa, and Asderson, R. Use ofanimalmodcls to study `Brmiannk-lemya,deJ. fLiebcehrncearrcainnodgeC.neHsairsr.isI.n:BCaenlbluulrayr RaenpdorMto,le1c8u3l-a2r05A,sp1e9c90t.sofFiber Carcinogenesis, eds. B. 2C5h.roHneistceirnbharlga,tiToWn.t,oxMiacsitty, oR.,f TMecfCroancntoerlyl,ceErEa,miCchefviableiresri,nJS,yBreirannshtaeimns,teDrMs.,PBurnno, WcB.eoaefndIdnAtniedmeanrtsigoonn,aslR. `M Worke shopc on han ofFii breCs arcinm ogenes sis, Albuquerque, NM, Oct. 1990. T26o.xiAconliomgayl,sNaastiSoennatlinReelsseoafrEcnhvCioruonncmieln,tNaaltiHoenaallthAcHaazdaermdys.PrBeosasr,d1o99n1E.nvironmental Srudics and a27n.dBTeally,loRrH,,KF.Ce.igRleevyi,eCw.oE.ftGahneu1ld1eSn.,AMmEa, EHnavlpierroinnm,eWn.,taHlaHrryigsi, cE.a, AKgiemmnecly,ToC.xAi.c,oKloodgyeD,ivRiLsi,oMn.cCCoonmnmeillt,teEeE. on Toxicology, National Research Councll, National Academy Press, 1991. P28r.ovGiodveeUrnncmeerntatinAcPcrooutencttiinong.OfGfAiOc/eP.ERMeD-p0r2o-d3u,ctWivaesahndinDegvtelooDpn.mC,e.nOtcatlobTeoxri,ca1n9t9s1:. Regulatory Actions 2e9s,poMscuCroen.neInl:lS,imEiEl.arCiotimepsaraantdiDvieffreersepnocnesses iBnor carcinogjlednreensisanbioassays:as a function of age akt fiArs:st Eds. PS. Guzelian. C.J. Henry and 5.5. On, ILS] Press, 1992. 30. McConnell, EE. Ethylencrhiourea (ETU): Comparative respionnrosdeent carcinogenesis studiesas a IfmupnlcitciaotnioofnsagfeoratRifsikrstAsesxepsossmuernet.,luE:dSsi.mlPSa.riGtuizecsalinadn,DiC.fJf.eHreenncreysBanedtw5e.5e.nOClhiin,ldILrSeInParnesdsA,d1u9l9t2s.: O31c.cuVaplaitdiitoynaofl MHeeatlhtohd,sWofrorldAsHseeaslstihngOrtghaeniCzaartciionno,geCnoipcietnyhaogfeMna,nD-emnaudnaerkFi,beMras.yE1u9r9o2p.ean Programme for R3e2.laHteisotnsehribperb,etTwWe.enMlcuCnognnbeilople,rEsiEs,tcMniclelear,ndW.bCio.loHgaidclaely,efJf.eGc.,tsBeorfnsmtaenin-,maD.dMe, viMtarseto,uRs.fiabnrdesAanfdteerrscohnr,onRi.c inhalation in rodents. Lyon, France, Sepr.. 1992. R3.3.CHhersotneircbeIrnhya,lTatWi.o,nMTcoCxiocninteyllo,f EFiEb.roMuisllGelra,sWs.Ci.,n RaHtasd.lePyr,oc1.eG.e,diBnegmsstoefitnh,eDEMi.gh,tBhuInnt,erWn.aBt.ioannadl CAonndfeerrseonnc,e on Lung Diseases, Prague, Czechoslovakia, Sept. 1992. 60 + R34A.W,McMCclCelolnanne,llR,.OE.,E.Miallnedr,RFeJi,nhHaersdt,erCbFe.rgA,pTprWo,acWhaershetiot,EvDa.lB.u,atBiunngn,thWeBT.oxiKcuintey,aAnBd.,CaLricpinpomgaennni,ciMt,y oMfast, MToaxnic`oMla,dePhaFirbmer.s:16S:u3m21m-a3r64y,of19a9W2.orkshop Held November 11-13, 1991, Durham, North Carolina. Reg. C35h.emSiecleaclteSadfSetyyn,thWeotrilcdOrHgeaanlitch FOirbgraensi.zaEtnivoinr,on1m9e9n3t.al Health Criteria #151, International Programe on e3f6f.eMcctsCoonfnechlrly,soEtEil.eCahnedvalcireocri,dHolJi,feHaessbiecsrbteorsgi,nTr:aWt.s,aHfatderleiyn,hJa.lGa.tiaonndeMxapsots,uRreW.forC2o4mpmaornitshosn,Ionf: tThoeticand CarcinogenicEffectsof Solid Particles in the Respiratory Tract, LSI Press, Washington, DC., 1994. E3f7f.ecWtasgonfeIrn,gBeMs.t,edBuFrltu,orBi.dAe,,CCaonmtmori,ttK.ePe.,oKnroTwosxkiic,olDo.g,yL,oNvya,tiSonMa.l MRceCsocnanreclhl,CoEunEc.ila,nNdatWihointaflorAdc,aGd.eM.myHealth Press, 1993. "3I8n.haHleasttieornbTeorxyi,ciMtiylloefr,MWa.nC-.m,aMdceCoVnitnreelolusEEF,ibeBres:rnsRteeliant,ioDnMsh,ipTthoeLvuennguzBuP.rdaenndaAnnddeLrusnogn,ReR.tenCthiroonn.icIn:+~~ T1o9x9i4c.andCarcinogenicEffectsofSolidParticlesintheRespiratory:Tract, ILS! Press, Washington, DC.. A HPe30a.leMtchCErofnfncmeeltlse,ofEtE,hGreraveis, nL, K-immIel,mC.pAA.r,mrKyodBeealtlt,glRe-LnD,reKasoslUltneriLfe.orMmdesd,inCsokmym,iMt.teaendonWoTlovxeinc-oGlaorgrye,t, A. National Research Council, National Academy Press, 1994. 40. McConnell, EE. Crit.Rev.Toxicol, 2a:n4:d54S9w-e5n5b3,er1g9,64J..A. Review of Styrene ond Styrene. Oxide : Long-term Animal Studies. 4e1x.peMrctCsoantnetlhle,hEeaEr.inRgesopnomnasen-tmoatdheesmeisnaenradlqfuiebsrtesi,onBsersliunbm9i/t1t0edDebcyeFmebdeerra1l9H9e3a.ltEhxcOefrfpitceinto the invited MKerthedizenVerl, Muchen, Germanliyche. Mineralfascer, (Ed. M. Fisher), pp.63-G5, Bga-Schriften 94.4, MMYV, 4F2o.wlFeirn,n,B,WF.GottHsecmhasltkr,eeC.tWI.l,,MGc.PC.o,nAnlelleln,, B.LCE..,NAonbdleer,sBo.,n,PaRrLke,r,BeJr.Cn.dra,ndW.P.or,teErp,stGe.iAn.,BFi.oHl.o,gFiocuMlakresk,erE.sCi.,n AIcraindareymyToxPriecsosl,og1y9,95B.oard on Environmental Studies and Toxicology, National Research Council, National 4O3b.erNdRoCrs.tLeri,ppG.m, aRnhno,mMb,erCgh,ia1zRz.e,e,UtLe.l,l,CoMu.l,taasn,dDWaBr.heDirti,scDo.lBl,,RKeEp,orKtaonne,thABe.ExLpeorctkepya,nc1lEo,nMcHCeoanlntehlElf,feEcEt,s. oafnAdsThoexsitcoosloagnyd,SNyanttihoenatlicRVeisteraerocuhsFCiobuenrcisl:,TNhaetIinofnlauleAncceaodfeFmiybePrreLses,ngptp.h,1B-o60a,rd20o0n0.Environmental Studies In4.flAuTeSncDeR.ofRFeipbaerrtLoefngtthhe.EAxTpSerDtR.PaDnive.l oHneaHletahltAhssEefsfsecCtosnosfulAt.sbeAsttlaonstaa,ndGAS.ynMtahretcihc1V7i,t2r0e0o3u.s Fibers: The Book Chapters, Published Symposia, Reviews: (Submtted,in press) Abstracts, Letters to Editor: 61 , c1.hlVoarnodStiefel,uoErWo.m,etMhcaCnoenn(eFl-2l2,).EEP,roPcaetee)d,in1Ag.s FainrdstHIanmtleirnn,atRioLn:alTChoengirnehsaslaotinoTnotxoixciocliotgyyo.f AthceadreefmriigcerParnets,s, New York, p. 602, 1978, . 2. Kimmel, assessment C.A., Grant, ofchronic LD. lead Fowler, toxicity. B.A. McConne Proceedings ll, EE. and First Interna Woods, JS.: tional Congr Anintegrated spproach to the ess on Toxicology. Academic Press, New York, p. 573, 1978. 3. McConnell, EE. and Moore, A: The comparative toxicity of chlorinated cibenzo-p-dioxin isomers in `mice, guinea pigs. ToxAi pplc.Phoarmlaco.l. 37:146, 1976. * d4.ibMecnCzoon-npel-ll,ioEiEn,inMomoircee,aJn.Ad.,juHairnreias,piMgWs.anadndrhHeassuesmmaonr,ikJeDy.s:.ETnhveirtoonx,icHietaylotfhcPhelrosrpi.na2t0e2d45, 1977. (5.TTChDiDg)poenn,hJoEs, rMecsCiosntnaenlcle,10EEi,nfMecotoiroeu,s1a.g4e.natsn.dEFnavitihr,oRn.EH:eaElftfhecPtesrsopf.22,03:,274,58,-1t07e7t.rachlo+rod*ibednizoox-ipn . h6.alMocgCeonnanteeldl,diEbEi.nasn,dfuMrcanKsi,nbnipehye,nylJ.D: sExaqnudisniatpehttohxailceintcysi.n TtheoguixneAaippplicg.Pfhooasrtmlrauccto.ulr.al4l3y:s2i9m8i,la1r978. c7.oMmomoerrec,iaJl.A,polLuysbtreorm,iMn..a,teGdubpitpah,enByNl.mainxtduMrceC.onTnelol,xEEA.piplTc,oPxhiocaorlmloagcio.cla.l a45n:d17i6m,mu1n9o7l8o,gical effects of a M8.ecMrciCnognnoefllth,eEIEn.tearnadgeMnocoyreC,olJl.aAb:orTaotixviecoGpraotuhpoloongyEnchvairraocntmeernisttailcsCaorfctihneogheanleosgiesn.atNeadtiaornoamlatCiacnsc.er45th Institute, May 23, 1979, Bethesda, MD. cc9.aormBcpoiaonrroagmteainnve,seiGcs.f.Af.cF,cerdMsecroCafotainnonnaeonlfilmAaLmEl,esrCaoicgckearneatlSlot,ciiBm.eeYt.io,efsDerfxeopwro,EsxRu.prTe.er,iaSmntedonnteeax,lpCoB.sJi.uo,lroHegayds,uerAmanatanih,oenJiXom.n, avinndylMocohlroer,idJeA: CA, April 13-18, The 1980. I110m9.8p0aM.cctKionfnCehyl,orJi.Dn.ataenddDMieoCxoinnnselaln,d EReEl:atSetdruCcotumrpaolusnpedcsifoicnittyheanEdnvti.hreondmioexnitn,rReocmepet,orI.talWyo, rOkctsohboepro2n2-24, (11T.CDMDc)Cotnonxeilcilt,y-ElEi.piadnadssSimhiolaaft,ioCnR.. 1.(1M9o8r1)phoSltoudgiye.sPohfrmthaecomleocghlastn,is2m31o7f62.,3,7,5-tetrachlorodibenzo-p-dioxin T12o.xiMccoCloongnyelFlo,ruEmE,: WaHsihsitnogplaothno,lDoCg.y w19o8r3k.load in carcinogenesis bioassays. How mu isnec cessh ary? The T1h3.eMTcoCxoincnoellolg,yEFEo:rumP,rolWiafsehriatnigvteolne,siDoCn,s o19f83t.he exocrine panercas in male F344 rats - the effect of con ofl. A11n. eSaolslyevcehlodi,ceH.wA.h,enHausseinmganth,Je KF.isacnhderMc4C4onnraerlla,s EaEt.estLianfiemsapla.n oAnmetrwioc-yaenarCosltluedgieeosffoVretcearricnianroygen festing: Pathologists, San Antonio, TY, 1983. g1u5.inMecaCopningeslolf,dLiEo,xinHairnrissoi,l.MWS,ocieHtayrovf,ToDxJic,olAolgbyr,o,AtPlWan.taa,nGdAH,as1s9,84.JR. Studies on the bioavailabiliityn 62 + I1n6t.eSronlalteivoenladl, SH.yAm.poansdiuMmcCoofnntehellS,ocEiEe:tyToifmTeo-xaigceolaosgsiocciPaattihoonlosgiinstesx,pAerrliimnegnttoanl, oVnAc,og1e9n8e-s4is. Third M17a.naMcgCionngneCloln,duEcEt:anQudaDliattyaaQnudaltihteyoNfatTiooxniacloTlooxgiycSotluodgiyesP,roRgarlacmi.gh NNCT,P-19I8n5d.ustry Joint Conference on S1t8u.dMiccsC.onInnetlelr,naEtEi:onaGluLiidfeeliSnceisenfcoersCIonmstbiitnutiengHiNsetooppaltahsomlsogfyorSEevmailnuaart,iHonanoofveRro,deGnetrmCaanrcyi,no1g08e5n.esis U19S.-DAudkticnhsiJrn.t.eBr.n,atMicoCnoanlneSlylm,poEsEi.umI:nhaAleartoisoonlsC,arWciilnloigaemnsebsuirsg,SVtiurdgyinoifa,Wo1l9l8a5s.tonite in Rats. Second C20a.rcMicnCoognenneilcilt,yESEt:udiOeps,tiCohnaspefolrHAilglg,rNeogratthioCnaroofliInnac,id1e9n8c6e.Dafa. Interdisciplinary Discussion Group on E21n.giMnceCerosn,nePlhlo,enEiEs:, AFriibzeornaT,oxi1c9i8t5y.: Beyond the Stanton Hypothesis. American Soc: iety of MiningA |' M22e.et.McCSooncn.eTlolx,icEoEl., HAetljatnmtaan,ciGkA,.M.19P8e9t.ers, A.C. Persing, R. Chroni. c Toxicityof Pentachlorophenol. Ann:. T2o3.xiAcdokli,nAs,liBt.aM,cCGoAm.nel19l8,9.EE. Hall, L. Carcinogenicity Studies of Wollastonite in Rats. Ann. Mect., Soc. 24. McConnell, of the National TEoEx.icHoalsoegmyaPnr,oJg.rA.amanDdatBaoBoarsmea.n,AnGn..AM.ecPtr.o.liSfoecr.atTiovxeicLoels.i.oMnsamoif,thFeLT,h1y9r9o0i.d Gland: A Review IE2L5x.SpIo/MsRcuSCIro,en.HnueinlnltS,iVmEaiEllla.eryiC,toimMepsDa,arnaNdtoivDveiefmfbReeerrse,npco1en9ss00eB.setiwneCeanrcCihniolgderneincaBnidoaAsdsualytss:asImaplFiucnacttiioonns offorARgieskatAFsisrestssment, RC2ah6t.rso.HneAiscmtneIr.nbhMearelgea,tti.ToSWnoc.T.oxMTiaocsxitit,cyoRal.n,dMDcaOlCnlocanos,ngeeTnlXi,,ciE1tE6y9,]SVtoaugldesyloT,oThfOo.eR,xeifChrceaovclatlooirgeyri,CseJt,raBmeircnsFtiebienr,sD(MRC.P)anidn FAinsdcehresro3n:,4R. 1185 (2514), 1950. . TE2o7f.xfeiMccctosClo.onfSneeChlarlly,es,oEtEWi,Ale.Hea1sn9td9e2rC,breoarclgisd,ooTTlTWiho.te,xe iAHcsabodellseotygo,siJs.iGnt.,R1aB2te:rs9n0Asft(et2ie7nr),I,nDh1Ma9.l9a2t.ainodn Mfaosrt1,0RMWo.ntAhsC.oAmmpna.rMieseotn.oSfotch.e S128t9.u92dG,ylaaoslfss,RoeLTfRhr.a,ecMTtaoosxrityc,CoRleoWrg.ai,msitHce1sF2tie:bre3rb7e(rR(y1C,4F7)T7W)i.,n,R1aA9tn9s2d.ersFionna,l RR.esaunltds.McACzo.pneMlelet,.ESEo.c.InThoaxliactoilo,n SOenactotglee,niWcAl,ty SO2e9n.actotMglaees,ntiW,cAiR,tVy1.S9t9M2uc,dCyoaonlfsnoeKTlaTlhoo,lexiEinEc,RoelGflroaagscsti,osrLtyR.C,12eH3re3as7mt7iecr(1bF4ei7rb8ge),r,T(1HR9.9C,2F.-A)ndFeirnaslonR,esRu.ltusn.dAnBne.rnsMtoeeitn,, DSoMc.. ToInxhiacloalt,ion E30f.feMctcsCoonfnCehlrly,soEtFi,leCahenvdalCircorc,idJo.lHiteestAesrbbeersgt,osTWin, RHaatdslaofyt,erJ.IGn.h,alaantdioMna.sitn, TRoWs.icoAloCgiocmpaanrdiCsaorncionfotgheenic 63 EGfefremcatsnyo,f S3oMliadrPcahrt1i9c93l.es in the Respiratory Tract. 4th International Inhalation Symposium, Hannover, March 1993. 31. Hesterberg, T.W., Miiller, W.C., McConnell, EE., Hadley, J.G., Bernstein, D.M., Thevenaz, P. and Anderson, R. Chronic Inhalation Toxicity of Fibrous Glass in Rats. in Toxicologic and Carcinogenic Effects of Solid Particles in the Respiratory Tract. Jth International Inhalation Symposium, Hannover, Germany, 3 I3n2t.rMatarsatc,heRaWl.,anGdlaBsiso,pLeRr.s,isMtceCnocnenSetluld,ieEsE.o,fHReesftrearcbteorrgy, CTe.Wr.a,miacndFiAbnedrse.rsionnT,osRi.cCohlorgoinciacnIndhCaalractiionno,genic Effects of Solid Particles in the Respiratory Tract. 41h International Inhalation Symposium, Hannover, Germany, 3 March 1993. . (63), 1993. i : 33. Mast, RW., McConnell, EE, Glass, LR. and Hesterberg, T.W. A Multiple Dose Chronic Inhalation toxicity Study of Kaolin Refractory Ceramic Fiber (RCF) in Male Fischer 344 Rats.TThhexicologist 13:43 7C3h4)r..yMsco1Ct9oi9nl3en.calnld, CErEoc.idHoelsitteerbAesrbge,sTtoWs.inHaRdaltesy,afJt.eGr.,IanhnadlaMtaisotn, -R2W4. MoAntCohmRpeasurlitsso.nTThoofextihceoElffoegcitssotf 13:43 3`2A54r.3oMc7la1oyre(sM1,i4x3B8t.)uA,r.,e1sN99eA4da.ila,inJ.iH.s,tPeerteedrsi,tAh.Ce.,DHiaemti0ltoSnp,ro$.gBu.,-MDcaCsonkneeylRla,tEsEf.oranSdiMMooonrteh,aJ..TAT.hoeChcroonlicoTgoxiicsity of 3R6e.spHoandsleesy.,TJTh.oGe.x,iMccCoolnongelils,tEE1.4:a4n2d0 J(1o6h6n5s)o,n,19N9.4F.. Fiber Inhalation Studies, Lung Burdens and Biological C31h79r.9y%sMoctCiolnenealnld,CEroEc,idHoelsitteerAbesrbgo,stTo.Ws.,inHtahdeleLyu,nJg.sG.oafnRdatMsusafstcelrmIannh,alRa.tiAonC.oTmhpearToixscoonloofgitshte E1:f4f:e4c2t1s(o1f666). 1995. 38. Mayes, B.A. Neal, BH., Peters, A.C., Hamilton, S.B., McConncll, EE. and Moore, J.A. Chronic toxicity of Aroclor mixtures administered in the diet to Sprague-Dawley rats for twelve months. TThoexicologics, 30. McConnell, EE. Letter to Editor: Cambelova and Juck,Occup,Environ.Med, 52:1995. Rodents. TThoexicologist, 30:01, 1996 40. Hesterberg, T.W., McConnell, E.E, Miiller, W.C., Chevalier, J., Everitt, J., Thevenaz, P., Fleissner, H., and Oberdorster, G. Estimating the Maximum Tolerated Dose (MTD) for a Fiber Chronic Inhalation Study in 41. McConnell, EE. Commentary on "Fibrous Glass and Lung Cancer", Am.1.Ind,Med., 1996. (scheduled for Sep. 1990 42. Hesterberg, T.W., McConnell, EE, Miiller, W.C., Chevalier, J., Everitt, J, Thevenaz, P., and Oberdorster, G. "Inhalation Toxicity of Synthetic Vitreous Fibers Compared to Amosite Asbestos in the Hamster", 43. McConnell, EE. "Commentary on "Fibrous Glass and Lung Cancer", Am.I.Ind.Med, 30:111-112, 1996. 64 104c04h.r7yM.scotCiolnenacnld,aEmEo.siMtiellaesrh,eWst.asHeisntehrabmesrtge,rsTWa.fteTrhienvhealnaatzi,onP:. IanntderAixmternes,ulCt.sA.TTchooexmipacroilsoogniosftt,he36e:f6fe(c3t3s),of Ta45on.sdicHOoelbsoetgregdriosbrtes,rtg3e,6r:T,6WG.(.35MS)cu,Cb1co9hn9rn7oe.nlilc,iEnhEa,laMtiilolners,tuW.d,y Cohfevfailbireoru,s.g,laEsvseriitntt,hJeTShyervieannagzo,ldP.e,nFhlaemissstneerr., THh.eHart, G, r46e.spMoanyseess, iBn.SA.prNaegiulc,-BDHan.lePeyterrast,s Toxicologist, 36158 (504), 1997. Af.eC.d, ArBorcohwlno,rsJ. 1F.61H6a,m1il0t4o2n,12S55.4,'aMncdCo1n2n6e0llf,orE. Et.woanydearMso.orTe,heJ.A. Tumor : 44a7n2.c:oM1gc7eCno(in8cn7e6c)lf,lf,c1c9Et9sE8,o.fMvialrliero,usW.t,ypHeesstoefrbaesrbge,stTo.sW.i,nTrhoedveenntasz,aftP.erainfderAitmeeni,nhCa.lAaticoonm.pTahoreissiocnolofogthiest, a48n.dHOebsetredrobresrtye,rT,WG.. AEsxttiemna,tiCn.g, Htahdelmery,siJs.nMucmCotnonleelrla,teEdEd,osMelloefrf,ibWe.r,gClhaesvsalfioerr,a JchrEovneircitttrhJ.a,lTathiepvnensatzu,dyP. * using Syran golden hamsters. The Toxicologist, 42:17 (877), 1998. . + 4t9o.ciAttyenf.tCw.oMtcyCpoensoneflflo,br.o.us.iHsesstearnbderas.maTs.iWe..asHbuedslteoys,a|s.bGe.s.tMosilienr,SyWr.ia.n Tohledveennahza,mPs.terasn.dTChhoeexvialcioelr,Jo.gCihrsotn,ic4i2n1hs1l7a7ion (880), 1998. a50f.teKralmosntgr-utper,mOi.,nhDaalavtiiso,n.JTTGho.exiEclollcnohgaiugset,,A4.8a(1n'd5)G,u1l9d9b9e.rg, M. Pathogenicity of man-made vitreous fibers f5i1b.eMrscCaofntnreliln,haElEa.tiUosneeoxfpotshuerer.odPernotcedeidaipnhgrsaogfmtahned7*thIonrtaecrincatwiaolnlaltoSdyemtpeorsmiinuemtornanPsaprlteiucrlaelTomxiigcroaltoigoyn.of Maastrich, The Netherlands. 13-13 October 1999. 5g2o.ldMecnCohnanmesltle,rsE.EPrAocccoamdpianrgissoofntohfe p7leuIrnatlermneastoitonhaelliSoymmapsosiinduumceodn bPyaratiscbleesTtooxsiaconldogSyV.-4M0aavsitrruischitn,STyrhiean Netherlands. 13-15 October 1999. o53f.poArxetnetni,alCpWa,thHoapdhlyesyi,oJl,ogHyes-tReersbuelrtgs, oT,f,aMccChornonnieclli,nhEaEl.atainodn sMitduldeyr..PFriobceerebdiionpgesrsoifsttheenc7eaIsntaenrniantdiiocnaatlor Symposium on Particle Toxicology. Maastricht, The Netherlmds. 13-15 October 1999. D5o4.ttT,heA.veInnafzl,uePnhc.eJoofnemse,thAoDd.olMoiglyleorn, Wr.e,poArxtteedn,lCunWg.buHredsetneragenrdg,fiTbeWr.c,oHnacdelnetyr,atJi,oMncsCfoonrneinlhla,laEtEi.onand sLattuedrineastiwointahlmSaynm-pmoasdieumfiboenrsP:aPrtairctle1T-oxAiecroolsoogly.geMnaearsattriiocnhta,nTdheexNpeotshuerrelamnedtsh.od1s3.-1P5roOcceteodbienrgs10o9f9.the 7 5256."MIcnCtoenmnaetlilo,naElE.CoAngSrceisesncoen-bOacsceudpAaptipornoaalchHetaoltthh,eSCilnagsaspiofrieca,ti2o7n-1ofSeSypnttehmebteicrV2i0t0r0e,ous Fibers. 5FP 44, W56o.rkDsehveolpo.pHiEngI,StIrnatteergniaetsiofnoarlAgIirfiecuSlctiuernaclesChIenmstiictuatle,SaWfaesthyiEnvgatlouant,iDonC;,ASeRpetpeomrbtefrr2o0m0a1n. April 22-23, 2001 Oral Presentation/ited Lecruyes: 65 11.96"5L.ymphosarcoma in Domestic Animals," Armed Forces Institute of Pathology, Washington, DC, March 2. The Clinician and Pathologist." South Africa VMA (WITS) Congress, May 1970. 13,07"0E.xperiences with Animals af the Kruger National Park, Veterinary Faculty, Onderstepoort, September 4. "The Role Pietersburg, OofctaoVbeetrer1i9n7a0r.ian in the US. Air Force." Eastern Transvaal Veterinary Medical Ass: ociation, S5.ep"tAnetmhbrearx1i9n7a1n African Buffalo from the Kruger National Park." Congress of the South African VMA, 61.97"2R.espiratory Acris in Chicana Baboons," Science Week-1972, WITS University, Jobanneo sburg, June o7.f"tPhaethVoeltoegriicnaalryObRseesrevaartcihonIsnsitnitu1t0e0, BOanbdoeornsstferpomootJrhuetlK,yru1g97e2r.National Park," Veterinary Faculty and Staff I8.ns"tLietsutieonosfiPnatFhrooleo-gRya,ngSienpgtBeambboeorns1,97"2.Pathology of the Discases of Laboratory Animals,ArmedForces T9.ox"iLceoslioognys,FWoruignhdt-iPnaAtntiemrasolns AEFxBp,osSeedptteomCboearl1T9a7r3.Aerosols," 4th Anm.ual ConferenceonEnvironmental 10. "Anthrax Antonio, TX, DinecaenmAbferric1a9n7B3u.ffalo." American College of VeterinaryPathologists Amal Meeting, San o11f. To"xTihceoCloogmypaArnanruiavle MTeoexitciintgy, oAftlCahnltoar,iGnAa,teMdaDricbhen1z9o7-6p.-dioxin Isomers in Mice an: d Guinea Pigs," Society 12. "The Toxicopathology of TCDD," Workshop on TCDD, Milan, Italy, October 1976. U13n.iv"eTrosxiitcyoloofgCiaclailfoRrensiea,arDcahviPsr,oOgcrtaombserat1t9h7e7.National Insitute of Environmental Health Sciences," O1c4.to"bTerrai1n9i7n7g.of Comparative Pathologists for a Career in Toxicology." University of California, Davis, a15n.d"NTaxpqhutishiatleenTeosx,ic"it1y7tihn AtnhneuGaulinMeeaetPiingg,toSoSctriuecttyuorfalTloyxSiicmoilloagry.HaSlaongeFrnaantceidscDoi,oxCiAn,s,MaFrurcahns1,97B8i,pbenyls S1c6.ie"ncTeosx,icNoepawthYoolrokg,yNYC,hJauranceter1i9s7t5i.cs of Halogenated Aromatics," Science Week, New York Academy of C17o.lu"mPabtuhso,loOgHy,aMnadyTo1x9i79c.ology of Chloradibenzodioxins in Laboratory Animals," Ohio State University, U18n.iv"erCshirtoyn,iCcoTlouximcbiutsy.ofOHT,ecMhaniyca1l97a9n.d Analytical Grade Pentachlorophezol in Cattle," Ohio State 66 + W1a9.sh"iCnogmtpoanr,atDiCv.eMTaoyvic1i9t7y9)of Related Halogenated Hydrocarbons," Armed Forces Institute of Pathology, G20r.ou"TphoenToExnivciorloongmyenotfaDlibCaernczionfougreanenssias,ndNaDtiiboennazlodCiaonxcienrs,I"ns4t5ittuhteM,eBeettihnegsdoaf,tMheD,InMtaeryag1e9n7c9.y Collaborative N21o.rt"hCoCmapraorliantaivSetaTtoexiUcniivteyrosfitTye,chRanlieciaglh,anNdC,AnJaulnyeti1c9al79P.entachlorophenol in Cattle," NIEHS Science Fair, D22i.se"aTsheeALsessoicoinastiIonnduMceeetdibngy,RUenliavteerdsiHtayloogfeOnkaltaehdoAmrao,mNatoircmsani,n VOaKr,ioAuusguSspetci1e9s79o.f Animals," 1979 Wildlife M2e3.et"iEnsgs,caNtIioElHsS,ofReRsoeuarricnhe TPrairahnogtloexiPcaorkl,ogNyC,EvNalouvaetmiobne,r" C1o97n9s.ensus Devlopment of Immunotosicology A2g4r.i"cTuolxtiucraolpaRtehsoelaorgicchaulnSdynDdevseolmoepImnednutceCednbteyrR,eWloaotsetdeHra,lOoFg,enAautgeudsPtol1y9c8y0cl.ic Hydrocarbons," OhiPo . . D2i5s.tr"iTchteINVaAtiAoLnAalSTSoexmiicnoalro,gyRaPlreiogghr,amN,C",CMoanrscerhva19t8i1v.e Trends in Lab\oratory Animal Science, Eighth Annua;l P2h6.th"aNlTatPeTEesstteirngCoRnefseurletnscwei,tWhaEsmhpihngatsoins,oDnC,BiJouansesa1y9s8o1f. DEHP, DEHA and Butyl Benzyl Phthalate," o27f.t"hEefSfcocctisetoyfoSfuTbocxhircoonliocgyC,hlRoersdceacrocnhcTrEixapnogsluerPearokn, tNhCe,FJeartniulaitryyo1f9F8e2.male Rats," North Carolina Chapter W28a.sh"iEnvgaltuoant,ioDnC,ofDPeactehmobleorgy1R9e82q.uirements," Third Annual Meeting of the American College of Toxicology, U29S.EP"AN,IECHiSncAisnnbaetsit,osOHF,eeNdoivnegmSbteurdy19- 8H2amsters and Rats," Summary WorkshoponIngested Asbestos, F30o.r"uHmisAtnonpuaatlhoWliongtyerWoMrekeltoinagd,inArClairngctionno,geVnAe,siFsebBriuoaarsysa1y9s83- .How much is necessary?" The Toxicology , `31T.ox"iPcroolloigfyerFaotirvuemLe1s9i8o3nsAonfnutahel EWxionctreirneMePeatnicnrge,aAsrlininMgatolne,FV3A4,4FReabtrsua- rTyhe19E8f3fect of Corn OIL" The 92. "Toxic Oi Syndrome," WHO Meeting, Madrid, Spain, March 1983 ' T3o3.xi"cAonloIgimcprPoatvheodloPgriosttosc,oClrfyosrtaBlioCaitsys,ayVAS,tuMdaieys,1"9283n.d International Symposium of the Society of P3o4t.e"ntCiharlonHiecalTtohxiEcfifteyctosf oPfCBPsolaycnhdloRreilnaatteeddCBoimphpeonuylnsdsanidn RVealraitoeuds PAenrismisatlenStpeHcaielso,g"eCnaCtEeRdPHCyodnrfoecraernbcoenso,n NIEHS, Research Triangle Park, NC, September 1987 TO35rc.acnu"spTfaootxriicmoientraysl,oHfEaPszCpaBorsod,,sFPCionlalyuacsnhedld,orSbieynpaPttoeeldmybcDehirlboe1rn9iz8noa3ft.eudraBnisphaenndylDsib(ePnCzBso)diaonxdinCsh,l"oIrnotbeernnazteinoensalinWoCrapkaschiotporosn.and 67 L36a.ns"iDnigo,xiMnL,s DinectehembEenrvir19o8n3m,ent," Human Health and Toiciry Workshop, Mickigan State University, Bast D3i7.be"nTzooxfiucraannsd,C"aFrecdienroagteinoincoRfesApmoenrsiecsaninSoEcxipcetriicsmefnotraElxApneirmimaelnstaAldmBiinoilosgtye,reStd. DLiobuiesn,zoM-op,-dAiopsrins19n64d. M3e8.et"iLnegs,ioDnusrihnaAmn,iNmCa,lsApErxipo1s9e8.d4.to EDR," North Carolina Chapterof the Society of Toxicology Spring G3A9.,SMtaurdcihes19o8n1.the Bioavailability in Guinea Pigs of Dioxin in Soi," Society of Toxicology Meeting, Atlanta, 40. "NTP Program Update," European Toxicology Forum, Geneva Switzerland, September 1984. En4v1.ir"oTnhmeeRnetsaploTnosxeiocfolNoTgPy,tDoatyhteonR,ecOhoimom,eOncdtaotbieorns19o8f4.the Ad Hoc Pancl," 15th Conference2on. M42e.etNiantgi,oWnaaslhTionxgitcoonl,ogD.yC.P,roFegbrraumarStya1t9u8s5.and New Initiatives, The Toxicology Forum 1985 Anmual Winter S4t3a.ti"sRteilcealvaPnetrsNpoenc-tSitvaet,isAtmiecarlicBiaonaSstsaatyisItsiscuaelsA,s"sSocyimaptoiosni,uWmasohnilnogntgo-nt,erDm.CA.niMmaarlchCa1r9c8i5n.ogenicity Studies: A B"4h4.op"aTlheTrSahgoerdty,anTdheLoWnogrkTeersmPHoelaiclythPraonjedctE,nvNierwoanrmke,nNtaelwIJmeprascetys,,"MaCrocnhfe1r9e8n5c.e on the Implications of the U4n5i.v"eArsdiHtyocofRCeipnocritnnoantiC,hOehmiioc,aMlaCyar1c9i8n5.ogenesis Testing and Evaluation," Environmental Health Seminar, SH46ei.sptt"oeCphmaabtlehlroeln1og9ge8ys5.SaenmdiOnpaproorntutrhieiRcesprfoorduPcatthiavleogSiyssttseimnotfhLeaNbaotriaotnoarlyTAonxiimcaollso,gyHaPnroovg:erra,mG,eIrLmSaIny, `4A7An.nail"myaTslhises,JLHueassntiioofvniescra,itniGotenhrefmoaRranrCy,o,"mISbLeiSpn]tiHenimgsbtBeoerpnai1tg9hn5o5la.ongdyMSaelmiignnaarntoTnutmhoerRse.p(roordNuocttiCvoemSbyisntienmg oTfhLeamb)oriantSotratyistical S48y:stMeemthoyfl LIasboocryaatnorayteAn-iPmraellism,inHaarnyovSetr,udGyeRremsualntys,,"SLeSpTteHmibsetrop1a0t8h5o.logy Semionnathre Reproductive C49L. "DOavveirsvSiiexwthofAtnhneuaNlatSioynmaplosToixuimc,olCohgeyshPirroeg,rEanmglianntdh,eSUenpitteemdbeSrtat1e0s85a.nd Findings in Selected Studies." C510a9.n85c".eCrarIcnisntoitguetnee:s1i9s7S6t-u1d9i8c5s."ReCsoullltsegfiroonmRtehmeazUzSi,niN,atLiiovnianlg TinoxaicCohleomgiycPalroWgorralmd,aBnodlotghneaU,st.lNya,tiOocntaolber C$1h.em"iMceatlhyWloernled,ChBloolroigdnea.,MIeetlhyy,lOcchtloobreorfo1r9m8a5nd Trichlorocthylene." Collegium Ramazzini,Livingin a R52a.mo"zLzivienri,FoLciiviFnogrmiantioCnheDmuircianlgWAofrlladt,oxBionloCganrac,inIotagley,neOscitsoibnerRat1:95A5.Quantitative Study," Collegium 68 53. "The Toxicity of Methyl Isocyanatc in Rats and Mice," New Delhi and Madras, India, February 1986. "54Ev.al"uaRteisopno.n"sSeoctioctthyeofInTtoexgircaotiloongyofARnneucaolmmMeecntdiantgi,oNneswofOrtlheeanAsd, HLaoyc 1P9a8n6e.l on Carcinogencsis Testing and &55.To"xNiTcPSuSbtrsattaenggyesforSeCmoimnbairnPirnoggrNaemo,plEaPsAi,nsWafsohriEnvgatlouna,tiDo.nCo.fACparriclin1o9g6e6n.esis Studies." Office of Pesticides M56e.et"iEnngv,iSrto.nLmoeunitsa,lMiTsosxoiurcio,lAopigrinyl t1h9e86M,id-Eightics: Interfacing vith the Toxicologist," . FASE 70th Anmal A5p7r.i"lNT1P9'8s6.Response to the Ad Hoc Panel Recommendations,"i FEMA Anaual Meeting, Palm Beach, Florida, N58o.rt"hStCuadrioelsionna StthaeteToUxniicvietrysiotfyMMoitchryolbIisoolcoygaynaSteem,intaher CSehreimeis,caRlalReeisgph,onNsoirbtlhe CfaorrotlhienaB,hAoppraill D1i9s8a5s.ter," } S59t.ud"iOepstUiLoSnIsNfFo)r,ACghgirsepgelatHiiolnl oNforItnhciCdaernocleinDga,taJ.u"neIn1t9er8d6i.sciplinary Discussion Group on Carcinogenicity + A60s.pe"nN,TCPoElvoarlaudaot,ioJnuloyf1E9x8p6e.rimental Studies," The Toxicology Forum 1986 Annual Summer Meeting, TGLh.e"TNoTxPicRoelsopgoynFsoertuomth1e98R6epAonrntuoafltShuemAmdeHroMceePtainndgl,oAnspCehne,miCcoallorCaadroc,iJnuolgyen1e9s8i6s.Testing and Evaluation," O62c.to"bIenrh,al1a9t8io6n. Study of Wollast:onitc in Rats," SAE's 4th Annual Colloquium on Brakes, Atlantic City, NJ, M6a3.nu"fCaocntsuirdeerrsa'tiAosnssociinaDtieotnerDmriunginSgaftehteyESsutbismeactteidonMamxeitmiunrgn, TNoaslhevrialtleed, DToNs,e,N"ovPehmarbmearc,eu1t98i6c.al P4r.og"rCaumr.r"en2t6tShtaAtnusnuoafltMheecItsisnuge ooff tMhaexSiomciuemtyToofleTroaxtiecdolDoogsy,e W(aMsThDi)ngwtitohni,ntDh.Ce;UsFe.brNuaatriyo,na1l0T8o5xicology oGf5,Go"FveedrernamlenPetrcToespitcioolnosgiosftBs,oaBredthCeesrdtai,fiMcaDt,ionM,a"y,Sp1r9i8n5g.Meeting and Reception for Members of Associatioh C66h,lo"rGaabveangzeeSnteudPireosduinceMrisceAsasnocdiaRattiso,n"),PaWraasdhiicnhgltoorno,bDe.nCz.e,nJeulSyym19p8o7s.ium (Sponsored by CIT and GJ7u.ly"1N9T8P7.Database, Meeting of the Ad Hoc Working Group on Carciiogenicity Testing, Washington, D.C. E16n89.8v7iR.raopnpmoernattaelurHeaarltMhouCsoemuLniivterrecanadndRaHtaKliodgneenytTeudmOorrgsanWiocrskSsuhbocpo,mmEiPtAtSecei,enWcaeshAidnvgitsoonr,y DB.oCa.rdA,ugust 69. "Toxicology Learned the Hard Way," Principles of Toxicology, Boston Univ., August, 1986. 69 7109.85".Mouse Liver Tumors: The Problem," MouseLiver Carcinogenesis Conference, Austin, TX, November, "7119S.t8u8d."iBeiso.l"oCgoywIrssseueosniBniotshteatSitsattiicsst,icIalntEevmaaltuiaotniaoln AofgeRnocdyenftorCRaersccian: orgcehniocnitCyancer, Lyon, France, Deceriber, T7o2.xi"cPoiltfoaglilcs iPnatChaorlcoignyo",geDneecseimsbTeers,tin1g9,8"5.North Carolina State University, Graduate Course VMS 643 "Rodent R73e.se"aMracxhiTmruiamngTloeleCrhaatpetderD,osSeo:ciTethyefDoerbaRitsek,"ABnarloyoskiisn,gRseIsnesatritcuhteT,riWaansghlienPgatrokn,,NDC.,C.MaMya,y,1918998.9 and CE7i4nn.vci"irTnnhoaemteiSn,etaOarHlc,hHMefaoayrl.tAhd,1e9Aq8n9un.autaelBMieoeatsisnagy oDafttah:eCSroucdieetByifoolrogEynvVierriosnumseSnttaatilstGiecos,c"heTmriacset:rSyubasdtanHecaelstihn, . W75o.rk"Asnhiompal1,BCihoiacsasgaoy,:ILU,siJunngeP,ro1t9o8c9o;lAstlaanndtaI,ntGeAr.prDeetcinegmbReesrul1ts9,8"9.Regional Risk Assessment Workshops, 76. "Target Organ Toxicity in Carcinogenesis," Annual Summer Toxicology Forum, Aspen, CO, July, 1989. A77s.se"sTosxmiecnitty2TnedstMianngaagnedmeEnvatl,uaCthiuolna-bPhraocmtiRcaelseCaorncshidIenrsattiituotnes,."BaInngtekronka,tiTohnaaillaTnrda,inDiencgeWmobrekrsh1o98p9,on Risk t7h8.e S"VoicpideattyeoofnTotxhiecSoleoagryc,h MfioarmAid,eqFLu,aFteebrBuiaorays,sa1y99D0a.ta: CrudeBiology Versus Statistics," Annual Meeting of 79. "Biological Effects of Dictary Restriction: An International Conference", Washington, D.C. March 1990. 80. Principles of Route-10-Route Extrapolation," (Rapporteur, Hilton Head, SC, March 1990. L8a1bo"rMaotloercyu,lNarY,MMeacrhcahni1s9m9s0.of Fiber Cytotoxicity and Carcinogenesis, Banbury Center, Cold Spring Harbor g82e.no"tNoTxPicCCaarrcciinnooggeenne-ssiIsn,teWroprrledtaHtieoanlatlhPOrrogbalneimzsa,t"ioInn,teBrrnuastsieolnsa,lBWealrgkisumh,opJ:unEear1l9y9I0n.dicators of Non. 8139.90".Principles of Carcinogenesis," School of Pharmacy, Campbell University, Buies Creek, NC, October, HS84iu.nnlt"aCrVoiatmlipleeasyr.aatMniDdv,eDiNRfoefvseerpmeobnnceseres,sB1ei9nr9vC0a.crecninCohgielnderseinsaBnidoaAsdsualytss:aIsmaplFiucnacttiioonns offorARgieskatAsFisresstsEmxepnots,urIeL,S"I/RS], I85m.pl"iEctahtyiloennsefTohrioRuirseka:AssAeCsassmeenStr,udIyL,S"I/SRiSnIi,laHruintticsVaalnledy,DiMfDf,erNenocveesmBbeetrwe1e09n0,Children and Adults: DL8Gee.ccte"umPrbreeosrbal,se1mp9sa9r0at.nodfC"oTnosxiidceorlaogtiiconPsatihnotlhoegyD"escoiugrnsae,ndVMInSi e6r4p3r,etCaotliloengoefoRfoVdeetnetriCnaarrcyiMneodgiecniensei,sNSCtSudUi,es", 70 8U7n.ive"rTsoixtiyc,olMoagricchS,tu1d0i9e1s.", Manmade Mincral Fibers: Status of H.ealth Risk Assessment', Johns Hopkins "88Tr.iaFnigbleerPaTrokx,iMcatyy-1B99a1c.kground and Historical Perspective', Society of Tosicologic Pathologists, Research 8PA9gh.eanr"cmAianecsi"om,laloCgrByyisowtaaoslrskCasryhyI,ospsVuA*c,AsJ/RuUensveeieo1wf99Go1f.RAR"i,skInAtsesrensatsimoennatl SaoncdieOtMyBo'fsRReegpuolrattoorny TitosxAicpolopgylaind.icnaRetguilaotonry 9V0e.te"rTinhaerDyesSicgine,ncCeoDnedputc.tPaenndnsIynltvearnpiraerSattaitoenUonfivFeirbseirtyT,oxPiAc,itSyeSpttuedmiebse"r, A1.99L1.Boptree Lecture Serics, FM9i1ob.regr"saF"is,bteIornntTmro,axmiWucVroAall,ogFSyiebipentrEeRxmepbseecrrairm1ce0nh9t1Wa.olrAknsihmoapl,s:NaRteisounlatls IonfstSittuudtieefsowriOtchcNuoptautriaolnaalndSaMfeatny-aMnaddeHeMailntehr,al FD9i2ub.rehr"usCa"o,nn,WdoNurCc,ktsNahonodvpe:ImnAbtpeeprrrpro1ea9tc9ah1t.eiosnfoofFIunahlaulaaltiinogntShteudTioexsicoiftythaendToCxaircictiynoagnedniCcairtcyionfogseannicMitaydoefFMiabper-sM,ade. : +93Fe.brMuaanry-M1a99d2e.Fibers: Review of Toxicology Data', `02 Annual Tolicology Forum., Washington, D.C. 94. Invited testimony before the German MAK Commission on NMVF's. Munich, Germany, May 1002. 9O5f.fi"ceMafnor-MEaudroepFei,brCeosp:eVnahliadgietny.of19M-e2t0hMoadys,f1or99A2s.sessment of Carci.nogenicity of Fibres", WHO Regional 9263.S"oEvpal1u9a9t2i.on of Reduced Prorocols for Carcinogenicity Testi.ng of Chemicals", EPA, Washington, DC, 22W97o.rk"sChoomppa,rSatt.iPveetePrastbhuorlgo,gFyL,of2C0hJryasno1t9il9e4.and Crocidolite Asbestos", TIVA/NAIMA Fiber Science 9P8e.te"rRsebluartgi,onFsL,hi2p0BJeatnwe1e9n93P.ulmonary Fibrosis and Cancer", TIMA/NAIMA Fiber Science Workshop, St. . T9o9.xi"cTohleogTiocxiPcaotlhogoilcoPgiatynhoSlaofgeitsytAisnse2s0s0m0enAt..D.NaNteieodnaslfAorcaInddeumstyryo,f GScoiveenrcen,mWeansthainngdtAocna.dDeCm.ia1"0, RFoelbe1o9f03. TI1o0n0xh.ilca"otAliooCgnoicmSpayanmrdpiosCsaoirnucmio,nfotHghaeennniEocfvfEeefcrft,escGtoesforCfmhSaronylysio,tdi3lPMearaatrinccdlheCs1ro9inc9i5tdhoeliRteespAisfbaetsotroysTirnacRt.ats4tahftIenrteIrnnhaatliatoinoanl', H10e1a.t"hStHyarzeanred/sstoyfreBnuctaodxiiednee+ aRnesduSlttysroenfea,nHiemlaslinckair,ciFniongleannidc,it2y1 sAtpudries1"6,0I3ntemational Symposiura on M10i2c.hi"gTahneSItmapteacUtniovferTsoixtiyc,it3yJSutnuedi1e0s9i9n. the Regulatory Process", Dept. of Tosicology Seminar Series, 7 110939.3."The Toxicopathology of Inhaled Fibers", Department of Pathology, Michigan State University, 3 June "104In.tem"aPteieornaRlevSiyemwpionsiCuarmc,inAolgeexnaincdirtiya,BiVoAa,ss2a6ysJu-nUese1s9/9A3bu.ses", Society of Toxicologic Pathologists 12th IC1n0oh5n.aglraMetcsiCosonnonSnetluOldc,ycuEopEfa,tSiiKozanema-sslteHrpeauarpla,ttheO,.d,NMiMacuens,-sFmeralamdnaceenV,,i3tR.0r,eOoHcuetssotFbeierbrbeerr1sy9i,9n3T.F.Wi.s,chCehrev3a4l4ie/rN, RJa. tasn.d24TthhevIenntaezrn,aPt.ioCnharlonic B1e0r6l.inM,cGCoenrnmealnly,,E6E-.10InDveitceedmebxeprer1t99t3e.stimony before the German Ministry of the Environment on MMVE's. C10o7n.feMrceCnocnen,eUlnli,veErEs.it"yFiobferR-oicnhdeuscteedrpPautlhmoonlaorgiyynanedxpCerritiimceanltCaalraenUinmiatl,s.20PhDyescioelmobgeyra1n9d03C.ell Biology S1o0c8.ietMycCoofnRneeglull,aEtEo.ry"TTaolxci:cCoolongsyumaenrd PUhsaersmaancodlHoegayl,thBePtehresspdeac,tiMvDes,"3P1anJealnD-i1scFuesbsa1n9t9,4I,nternation] m10a9d.eMcFiCbornens,elPlar,isE,LE.Fr"anAcdev,an3tFaegbe.s1a9n9d4.limits of in vivo screening tests", Assessment of Toxicity of Man S1y10n.thMectCiconVnietlrle,ouEsE.Fib"eIrnsh:alSactiieonntiSftiucdaiensd:PMuebtlhiocdPoolloigcyieIsssuUcsse.dCarnysdtaClurCriteyn,tVSAt,ud2i-e3s"M,aSrycmhp1o0s0i4u.m on Po1a1f1t.AhnolMiocmgCaiolsntCnsae,rlCclii,nncoEigEne.nnait"ciHi,itsyOtHoSr,tiuc2dai4lcMsR,aevrGicrehewa1to9fL9a4tk.heesBDiiosacsussasyiaonndGFruotuupreofDitrheectSioocnise"t,yDoefsTiegxnicaonldogIincterpretation B1a1l2.timMocrCeo,nnMeDl,l, EMEa.rPcahne1l99m5e.mber "Workshop on Data Needs for Cancer Risk Assei ssment of MTEE", MO11vA3e,.rl2Mo9ca-Cd3o0ninnMeatlrhlec,hREaE1t9.8L5"u.Mnga:xiRemluemvaTnoclecrfaotreHduDmoasne vReirsskuAssLsuensgsmBeunrtd.enM:IAT TPoaxtihcoloolgoigsytsSyPmopinotsioufmV,ieCwa"m,bPrairdtigcel,e 114. "Dose Selection in Inhalation Studies", U.S. EPA Workshop, Chipil Hill, NC, 9-10 May 1995. 115. "US. EPA Science Advisory Board Dioxin Reassessment Review", Herdon, VA, 15-16 May 1995. 111969.5"FIFRA SAP Review, Chairman, Aquatic Risk Assessment and Mitigation, Crystal City, VA, 17 July T1o1l7e.r"atEeUdRDOoTsOeX",-SPOraTguDeE,BAChTeEc"hDRoespeubSleitct,in2g0foAruCgar1c9i9n5geannicdiAtynaShteuidime,sCSAho1u2ldMbarecBhas1e9d96o,n the Maximum IF1ni1d7b.ursets"rRiyen,suRSloytddsenneotfys,L"i,AfuSscty-rimampleioasI,nihu3am0l-a3ot1nioOtnchtSeorbuHederia,clst1ho99fE5fG.fleacstss,oMfinFcirbarlouasnMdatSelraigaWloso(lesxcalnuddiRnegfarsabcetsotroysC)eUrsaemdicin ALs18s.es"sTmheentR,odAeunsttiBni,oaTsXs,a4y DiencPeermsbpeercti1v9e9"6,, 10h International Conference on Carcinogenesis & Risk 72 + oA1fn19nc.uhiaMylcsCoMotenielnteeilnalgn,,dECaiEmn,ocsiMinitaltleetrai,s,bWO.e,Hst,Hoes1s9ti9ne7r.hbaemrgs,teTrWs.a,ftTehreivnehnaalza,tioP.n:anIndtAerxitmenr,eCs.tAs.cSoomcpeatryisoofnToofvitcheeloefgfyects D1.2C0..3McACporninle1l9l5.7E.E. Selecting Doses for Chronic Rodent .Bioassoys. Brookings Institution. Washington, V1i2r1g.inMicaC,o2n8neAlplri,l,EE1.90R7e.gulatory Toxicologs: lecture for "Principles of Pharmacology', Medical College of JT1u2h2ny.reoM1ic9dC9l7Fa.uinnc.tiMo.n:anThdyMrcoCiodnnHieslolp,aEtEh.ol"oWgoyraknsdhoSpeornumScHroerenmionngeMAentahloydsissf"oDruEknedoUcnriivneresDitiys,ruDputrohrasmi,n NthCe, 24 A1l2e3x.aMndcrCioan,neVlAl,1E6EA.prUiplda1t9e98o.n the 10X Childrens Safety Factor. Pesticide Program Dialogue Comumitice, . HS1e2up4m.taeMmncbCeRorensnp1ei9lr9la8,t.oErEy.DCiasnecaseers.anLdovNeolna-cCeaRnecseprirRaetsorpyonRseesseatrocIhnhInaslietdi!tFuitbeerssy,mVpaolsidiiutmy,ofSaAnntiamFael, MNovd,dl2s6 for. * I1n2t5e.rnMactCioonnnaellSly.mEpEo.sAiuSmciocnncPea-rbtaisceled TPoaxriacdoiloggmy.foMratahseirCilcashs,ifTihceatNieotnhoefrlSaynndtsh,et1i3c-V1i5trOecotuosbFeirbe0r6s,9,7 EO1xc2p6te.orbMiecmreCno1tn9an9le9l.PlatEhEo.loSgiymiBlraraintcihe,s NaantdioDniaslsiImnisltairtiuttieesofofEnMveisrootnhmeelnitoamla.sHeIanldtuhcSecdiebnyceAss(bVeIsFt)o,sRapn,d NSCV.403.7 D1e27f.enMsceCoRensneealrlchEEI.nsAtitCuotme'psar2i0soAnnnofuaAlsbAessbteosstoasndMeSdiimciianneVMiereutsin4g0,ILnadsuVceegdaMs,esNoVt.h1e2liNoomvsemibneArni5ma0l0s". I1n2t8e.rMncaCtoinonne:lClo,nEgEr.esAsSocnieOnccceu-phaatsieodnAalppHreoaaltchh,tSointghaepoClraes,si3f0icAautgiounstof2S0y0n0t.hetic Vitreous Fibers. 26 422000,1 MacnCdonNanteilolnaElE.InFsotoittutuenodfMEonuvtihroDmisecnatsael: AHeRaletvhieSwciLeenscieosn,s,NINHo,r6thJuCnareo2l0i0na1.State University, Apr. | T21o340x.JiucMoncleCo2go0yn0nP1erlolgrEaE.m BAinoiamsaslayCRaenccseurltSst.udInisetsitoufteSoodfiFuomodNiTietceh:noHliosgtiosrticsalanRneuvailemweaentidnRge,cNenetwNOartlieoannasl, LA, M13e1d.icMicnCeonMneeetliln,gE,E.PhoAenniimxa,lATZe.st2iNngovaenmdbCehrry2so0t0i1l.e. Defensc Rescarch Institute's 22nd Annual Asbestos R1e3s2.eaMrecChoTnrnilalng,lEeEP.arAkn,thNrCa.x.1i4nNSoovuetmhbAefrric2a0.01N.ational Institute of Environmental Health Sciences, N13o3v.emMcbCeornn2e0l01l., EE. Anthrax in South Alfica. Colle of Veterinary Medicine, NCSU, Raleigh, NC. 17 73 P3u3b4l:icMcPCoolincnye.lNl,ewEEY.or"kThAecVaadleuemyofofHMuemdainciTnees.tNinYgC,ofNPYe.st2i7ciFdeebs.r"uaPreyst3ic0i0d5e Testing in Humans: Ethics and "13I5nt.ensMicvCeonWnoerlkls,hEoEp.. "NHourmtahnCaDraotlainianSRtiastkeAUsnsiveesrssmietny,t",ACpurrire3n0tT0o5.picsin Pesticide ToxicologAyn: 11316". NMocrCtohnAnemlelr,icE.aEn. I"SScSiXeMneceetainngd,Po2l5itOiccstoibneHru2m00a5n, Testing of Pesticides", Pesticides in`the Molecular Age. FFSii3nb7e:ecrtMLsce?Cn)ogtnAhnT.eSllDN.ReEwEEx.Ypoe"rrkHt,oPwNaYnd.eol2A0on:ni3m0HaeOlac/ltEtoxhbpEeefrrfie2cm0te0sn3ot,fDAastbaeAstuogsmeanndt SoyunrtUhnednetrspotraonsdsi(nSgVEo:fTHhuemIanfnluHeenacltehof TTooxxiicaintyeCRoensaeealrlchEEw.it"hTHheumVaalnueReofseHaurcmhanParTteisctiipanngt"s.NRWaCs/hNiAngStCono,mmbiet.t1ege Foniatht2e0U0se3"of Third Party, 1PFoaarsrtaBiobcmluaeacsCtAoesnsnCoeaclrilcaitEneEod.gew"niIitnchgePTsoattcieoonnnitStiteauldainIednstteohrfneaAAtsdibojenasactleonSstyamDnupdlousNtiohru:mCAoosmbnepfshrteoesHPearaticslesafnsExEpvearliumaetnitoanloAfnFiimbarlosus t2Lo0a0sA3e.DpeesctoonsneFlilb,erEs(AInnifmlauleSntcuedoiefsF)i.beArsbTeyspte,osSiMzeecahnadniEsxmpsosoufrTeoiwnidtheeyCWaonrckesrhoapn,dCNhoinc-acgaon,cIeLr. R1e2s-1p3onJsuene 74