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Birthplace: Birthdate: Married: Children: Education: Employment: CURRICULUM VITAE Perry James Gehring Yankton, South Dakota March IS, 1936 1959, Barbara Tennis Daniel, 1961; Matthew, 1964; Elizabeth, 1966; Heidi, 1971. Elementary and Secondary Schools Yankton, S. Dakota Graduated University of Minnesota in 1960 with B.S. and D.V.M. degrees. Attended Iowa State University 1960-1961; Graduate work in physiology at Baylor Univ. Summer, 1961, no degree. Graduated University of Minnesota, Ph.D. in 1965. Major in Pharmacology and Minor in Physical Chemistry. Thesis: The Interrelationship Between Thallium and Potassium in Animals. 1960-1961, Iowa State University; Research Associate in Dept, of Veterinary Physiology and Pharmacology. Financed by Atomic Energy Commission. 1961-1965, University of Minnesota, Research Fellow in Dept, of Veterinary Physiology and Pharmacology. Financed by National Institute of Health. September 1, 1965, The Dow Chemical Company, Research Pharmacologist. June, 1968, Group Leader - Biochemical Research Laboratory, Toxicology Research. November 15, 1968, Associate Professor, Pharmacology Dept. Michigan State Univ. September 1, 1970, Assistant Director, Toxicology Research Laboratory, The Dow Chemical Company, Midland, Michigan December 11, 1973, Director, Toxicology Res arch Laboratory, The Dow Chemical Company Midland, Michigan R&S162139 e Professional Organization Memberships: Other Professional Activities: HonorsRecognitions: -2 Society of Toxicology American Society of Pharmacology and Experimental Thereapeutics. New York Academy of .Sciences Minnesota Veterinary Medical Association Board of Editors of the Journal Toxicology and Applied Pharmacology. Visiting Professor, Dept, of Pharmacology, Michigan State Univ, E. Lansing, Michigan Undergraduate Graduated with honors Scholastic All-Big Ten Conference Football Team Scholastic All American Football Team, Honorable mention on others. Big Ten Conference Medal, 1958 for most out standing combination of athletic and scholastic performance. Associated Press and United Press Lineman of the Week, twice 1956 & 1957 North-South All Star Football Game, 1958 Graduate U. S. Public Health service - Postdoctoral Research Grant. Professional The Deans Advisory Council, Michigan State Univ. 1968-1970, Elected Chairman 1969. Curriculum Committee, College of Veterinary Medicine, Michigan State Univ. 1969. Program Committee for Annual Meeting, Society of Toxicology, 1973. Recipient of U. S. Public Health Service Research Grant, 1968. Member of Scientific Committee of the Animal Drug Section, Animal Health Institute. Listed in: American Men of Science Who's Who in the Midwest Who's Who in America Who's who in the World R&S162140 Revised 1/23/74 PUBLICATIONS P. J. Gehring, D.V.M., Ph.D. 1) Gehring, P. J. ard Hannond, P. B.: The uptake of thallium by rabbit erythrocytes. J. Pharmacol. Exp. Therap. 145:215-221, 1964. 2) Gehring, P. J. and Hammond, P. B.: The interrelationship between thallium and potassium in animals. J. Pharmacol. Exp. Therap. 155:187-201, 1967. 3) Gehring, P. J., Torkelson, T. R. and Oyen, F.: A comparison of the lethality of chlorinated pyridines and a study of the acute toxicity of chloropyridine. Toxicol. Appl. Phraroacol. 11:361-371, 1967. 4) Gehring, P. J.: Hepatotoxic potency of various chlorinated hydrocarbon vapors relative to their narcotic and lethal potencies in mice. Toxicol. Appl. Pharmacol. 13:287, 1968. 5) Gehring, P. J.: Thallium Toxicity, Current Veterinary Therapy 111, 3rd.Ed. Biited by R. W. Kirk, W. B. Saunders Co., Philadelphia, 1968. 6) Gehring, P. J. and Buerge, J.: The cataractogenic activity of 2,4-dinitrophenol in ducks and rabbits. Toxicol, and Appl. Pharmacol. . 14:475, 1969. 7) Gehring, P. J. and Buerge, J.: The distribution of 2,4-dinitrophenol relative to its cataractogenic activity in ducks and rabbits. Toxicol, and Appl. Pharmacol. 15:574-592, 1969. Rao, K. S. and Gehring, P. J.: Acute toxicity of Aflatoxin Bi in monkeys. Toxicol, and Appl. Pharmacol. 19:169-175, 1971. 9) Eisenan, J. L., Gehring, P. j., and Gibson, J. E.: The In VitAJO metabolism of 2,4,-dinitrophenol by rat liver homogenates. and Appl. Pharmacol. 21:275-285, 1972. Toxicol, 10) Schwetz, B. A. Sparschu, G. L., and Gehring, P. J.: The effect of 2,4-dichlorophenoxyacetic acid (2,4-D) and esters of 2,4-D on rat fetal and neonatal growth and development. Food and Cbsnetic Tox. jh 801-817, 1971. 11) Gehring, P.J.: Toxicity of pyridine, piperidine, quinoline ard their derivatives. Encyclopaedia of Occupational Health and Safety. Biited by L. Parmeggiam. and Published by the International labour Office. Geneva. I/K-Z. 1971 12) Gehring, P. j. and Rowe, V. K.: Carbon Tetrachloride. Encyclopaedia of Occupational Health and Safety. Biited by L. Parmeggiani and Published by the International labour Office. Geneva, I/A-K:256-257, R&S162141 C -2- 13) le Beau, J. E. and Gehring, P. J.: Studies on the mechanism of the cataractogenic activity of 2,4-Dinitrorihenol. Toxiaol. and Appl. Pharmacol. 19:403, 1971 14) Gehring) P. J. and MacDougall, D.: Review of the toxicity of hexachlarobenzene and hexachlorobutadiene. A Special release of The Dow Chemical Company, August 1971. 15) Gehring,P.J.: Cataractogenic activity of chanicals. Critical Reviews in Toxicology, 1:93-118, 1971. 16) Kociba, R. J., Gehring, P. J., Humistan, C. G., and Sparschn, G. L.: Toxicological study of female rats administered hexachlorobutadiene or hexachlorobenzene for thirty days. A special release of Die Dew Chemical Company, August 1971. 17) Rowe, V. K., Norris, J. M., Schwetz, B. A., Sparschu, G. L. Gehring, P. J., Bnerson, J. L. and Gerbig, C. G.: Toxicology of chlorinated dibsnzo--p-- dioxins. Adv. in Chemistry Series 120, "Chlorodioxins- Origin and Fate", ed by E. H. Blair, Am. Chem Soc., Washington, D. C., p 30-69, 1973. 18) Piper, W. N., Rose, J. Q., and Gehring, P. J.: Excretion and tissue distribution of 2,3,7,8-tetrachlorodibenzo-p-dicxin in the rat. -Mv. in Chem. Series 120, "Qilorodioxins--Origin and Fate", ed by E. H. Blair, Am. Chem. Soc. Washington, D.C., 1973, p 85-91. 19) Gehring, P. J., Kramer, C. G., Schwetz, B. A., Rose, J. Q. and Rowe, V.K. Tie fate of 2,4,5-trichlaropheno^acetic acid (2,4,5-T) following oral administration to man. Toxicol. and Appl. Phamacol. 26, 352-361, 1973. -- 20) Piper, W. N., Rose, J. Q., long, M. L. and Gehring, P. J.: Tie fate of 2,4,5-trichlorophenoxyaoetic acid (2,4,5-T) following oral administra tion to rats and dogs. Toxicol. Appl. Pharmacol. 26, 339-351, 1973. 21) Kociba, R. J., Sparschu, G. L., Lecng, B.K.J. and Gehring, P. J.: Tissue response to ceramic foam dust following intratracheal and intxaperitoneal administration. Toxicol. Appl. Pharmacol. 25, 145-151, 1973 22) Schwetz, B. A., Norris, J. M., Sparschu, G. L., Rowe, V. K., Gehring, P. J. Emerson, J. L. and Gerbig., C. G. Toxicology of chlorinated dibenzo-pdioxins. Ehviron. Hlth. Perspectives. Exp. Issue 5:87-89, 1973 23) Johnson, R. L., Gehring, P. J., Kociba, R. J. and Schwetz, B. A. Chlorinated dibenzo-p-dioxins and pentachlorophenol. Ehviron. Hlth. Eterspectives. Exp. Issue 5:171-175, 1973. R&S162142 L -3- 24) Piper, W. N., Rose, J. Q. and Gehring, P. J. Excretion and tissue distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. Environ. Hit. Perspectives. Ejp. Issue 5:241-244, 1973 25) Schwatz, B. A., Keeler, P. A. and Gehring, P. J. Effect of purified and commercial grade tetrachlorophenol on rat enbryonal and fetal development. TOxicol. Appl. Pharmacol. In Press. 26) Schwetz, B. A., Spencer, H. C. and Gehring, P. J. A study of the prenatal and postnatal toxicity of a sulfhydryl resin in rats. Tbxicol. Appl. Pharmacol. In Press. 27) Eiseman, J. L., Gehring, P. J. and Gibson, J. E. Kinetics of Jin vJL&io reduction of 2,4-dinitrophenol by rat liver hcmogenates. Tbxicol. Appl. Pharmacol. In Press. 28) Schwetz, B. A., Ieong, B.K.J. and Gehring, P. J. Etbryo and fetotoxicity of inhaled chloroform in rats. Tbxicol. Appl. Pharmacol. In Press. 29) Schwetz, B. A., Leong, B.K.J. and Gehring, P. J. Errbryo- and fetotoxicity of inhaled carbon tetrachloride, 1,1-dichloroethane and methylethyl ketone in rats. Tbxicol. Appl. Pharmacol. In Press. 30) J. B. Hook, Bailie, M. D., Johnson, J. T. and Gehring, P. J. Th I>Z&io analysis of transport of 2,4,5-txichlorophenoxyacetic acid (2,4,5-T) by rat and dog kidney* Pood and Cosmetics Tbxicol. In Press. 31) Gehring, P. J.: Tbxic minerals in Veterinary Pharmacology and Therapeutics 4th Ed. Edited by p. B. Hammond and C. M. Stowe, Iowa State Univ. Press. In Press. 32) Gehring, P. J.: Miscellaneous toxic agents. Veterinary 'Pharmacology and' Therapeutics 4th Ed. Edited by P. B. Eamnond arid C. v. Stowe, Iowa State Univ. Press. In Press. 33) Gehring, P. J., Rcwe, V. K., and McCbllister, S. B.: Tbodcology: Cost/Time. Food and Cosmetics Tbxicol. in Press. 34) Braun, W. H., Ramsey, J. C. and Gehring, P. J. The lack significant absorption of methylcellulose, viscosity 3300 cps from the gastrointestinal tract following single and multiple oral doses to the rat. Food and Cosmetics Tbxicol. In Press. 35) Ramsey, J. C., Rase, J. Q., Braun, W. H., and Gehring, P. J. Fate of 6-chloro-picolinic acid following oral administration in rats. J. Agri. Food Chera. In Press. 36) Kociba, R. J., McCbllister, S. B., Park, C. ,Torkelsan, T. R- and Gehring, P. J. 1,4-dioxane: I Results of two-year ingestion studies in rats. Tbxicol. Appl. Pharmacol. Th Press. R&S162143 L 37) Schwetz, B. A. and Gehring, P. J. Placental transfer of 2,4-D and 2,4,5-T in pregnant rats. toxicol. Appl. Pharmacol. In Press. 38) WcCollister, S. B., Kociba, R. J. and Gehring, P. J. Studies on the acute and chronic oral toxicity of 0,0-diethyl-0- C3,5,6-trichloro~2pyridyl) phosphorothioate. Food and Cosiretics Toxicol. In Press. 39) Morris, J. M., Ehrmantraut, J. W., Gibbons, C. L., Kbciba, R. J., Schwetz, B. A., Rose, J. Q., Humiston, C. G., Jewett, G. L., Crunnatt, W. B., Gehring, P. J., Tirsell, J. B. and Brosier, J. S. toxicological and environmental factors involved in the selection of decabramodiphenyl oxide as a fire retardant chemical. Applied Polymer Symposium, J. Wiley & Sons, Inc. No. 22:195-219, 1973 40) Norris, J. M., Ehrmantraut, J. W., Gibbons, C. L., Kbciba, R. J. Schwetz, B. A., Rose, J. Q., Humiston, C. G., Jewett, G. L. Crummett, W. B., Gehring, P. J., Tirsell, J. B., and Brosier, J. S. toxicological and environmental factors involved in the selection of decabrcmodiphenyl oxide as a fire retardant chemical. J. Fire and Flanmability. In Press. 41) McCollister, S. B., Kbciba, R. J. and Gehring, P. J. Ninety-day repeated oral toxicity of 2,4,5-trichlorophenoxyacetic acid in rats. Food and Cosmetics toxicol. In Press. . R&S162144 Itevised 1/23/74 ABSTRACTS AND/OR PAPERS PRESENTED P. J. Gehring, D.V.M., Ph.D. 1) Gehring, P. J. and Hamnond, P. B. The uptake of thallium by rabbit erythrocytes. Fall Meeting. Am. Soc. Pharnacol. E^d. Iherap., 1964. 2) Gehring, P. J. and Haimond, P. B. Mechanism for the increase in thallium excretion during the administration of potassium. Fall Meeting. Am. Soc. Pharmacol. Exp. 'Iherap., 1966. 3) Gehring, P. J. and Hammond, P. B. Effect of dietary potassium on the rate of thallium excretion fran rats and dogs. Spring Meeting. Society of dbxicology, 1966. 4) Gehring, P. J. Acute toxicity of chlorinated pyridines. Spring Meeting Society of lexicology, 1967. 5) Gehring, P. J. Ihe distribution of 2,4-dinitrophenol (DNP) relative to its cataractogenic activity in ducklings and rabbits. Fall Meeting. Am. Soc. Pharmacol. Exp. Iherap., 1969. 7) leBeau, J. E. and Gehring, P. J. Studies on the mechanism of the cataractogenic activity of 2,4-dinitrophenol. Society of Toxicology 1971. 8) Eiseman, J. L., Gehring, P. J., and Gibson, J. E. Ihe Zn v-Lt/io metabolism of 2,4-dinitrophenol by rat liver. Fed. Am. Soc. Exp. Biology 1971. (Federation Proc. 30:186, 1971) 9) Rowe, V. K., Norris, J. M. Schwetz, B. A. Sparschu, G. L., Gehring, P. J., Ererson, J. L., and Gerbig, C. G. Am. Chem. Soc. Synposium an Pesticides, Washington, DC Sept. 1971. 10) Piper, W. N. ,Rose, J. Q., Gehring, P. J. Excretion and tissue distribution of 2,3-7,8-tetrachlorodibenzo-p-dioxin in the rat. Am. Qiem. Soc. Symposium an Pesticides, Washington, DC Sept. 1971. 11) Hayes, F. D., Gehring, P. J., and Gibson, J. E. Studies on the acute toxicity of monochloracetic acid in rats. 11th Annual Meeting Society of Toxicology, Williamsburg, VA March 5-9, 1972 12) Piper, W. N. ,Kose, J. Q., and Gehring, P. J. Metabolism of 2,4,5-T in rats. Hth Annual Meeting, Society of Toxicology, Williamsburg, VA. March'5-9, 1972 i-3: Cchring, P. J., Rcwe, V. K., and McCollister, S. B. Toxicology: Cost/Time. Presented at American Chemical Society Synposium "Economics of Pesticides - Current and Future". 163rd ACS National Meeting, Boston, Mass., April 9-14, 1972. 14) Gehring, P. J. and Rcwe, V. K. Urethane glycols toxicology. Gordon Research Conference - "Chemistry and Physics of Cellular Materials", N. Hanpton School, New Hamton, NJ, August,1972. R&S162145 2- - 15) Gehring, P. J., Kramer, C. G. , Schwetz, B. A., Rose, J. Q. , Rowe, V. K. and Zimmer, J. A. The fate of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) following oral administration to man. 12th Ann. Meeting, Society of Toxicology, March, 1973 Toxicol. Appl. Pharmacol. 25:455, 1973 16) Schwetz, B. A. and Gehring, P. J. The effect of tetrachlorophenol and pentachlorophenol on rat embryonal and fetal development. 12th Ann. Meeting Society of Toxicology, March, 1973. Toxicol. Appl. Pharmacol. 25:455, 1973. 17) Norris, J. M., Kociba, R. J., Schwetz, B. A., Rose, J. Q., Humiston, C. G., and Gehring, P. J. Toxicological evaluation of fire retardant chemicals: decabromodiphenyl oxide and octabromobiphenyl. Fall Meeting Am. Soc. Pharmacol. Exp. Therap. The Pharmacologist 15:394, 1973. 18) McCollister, Susan B., Kociba, Richard J. and Gehring, Perry J. Studies on the acute and chronic oral toxicity of 0,0-diethvl0- (3,5,6-trichloro-2-pyridyl)phosphorothioate. Fall Meeting Am. Soc. Pharmacol. Exp. Therap. The Pharmacologist 15:396, 1973 19) LeBeau, J. E., Humiston, C. G., Rose, J. Q, and Gehring, P. J. Toxicological properties and metabolic fate of 2,2-dibromo3-nitrilopropionamide (DBNFA). Fall Meeting Am. Soc. Pharmacol. Exp. Therap. The Pharmacologist 15:395, 1973. 20) Schwetz, Gehring, P. J. and Kociba, R. J. Toxicological properties of pentachlorophenol relative to its content of chlorinated dibenzo-p-dioxins. Fall Meeting Am. Soc. Pharmacol. Exp. Therap. The Pharmacologist 15:397,1973. 21) Ramsey, John C., Rose, James Q., Braun, Werner , and Gehring, Perry. Fate of 6-chloropicolinic acid following oral administration in rats. Fall Meeting Am. Soc. Pharmacol. Exp. Therap. The Pharmacologist 15:406, 1973. 22) Schwetz, B. A., Norris, J. M., Sparschu, G. L, Rowe, V. K. , Gehring, P. J.,Emerson, J. L. and Gerbig, C. G. Toxicology Toxicology of chlorinated dibenzo-p- dioxins. Conference on "Dibenzodioxins and Dibenzofurans" sponsored by Nat. Inst. Environ. Hit. Sci. Res. Triangle Park. N. Car. April, 1973. 23) Johnson, R. L. Gehring, P. J., Kociba, R. J. and Schwetz, B. A. Chlorinated dibenzo-p- dioxins and pentachlorophenol. Conference on "Dibenzodioxins and Dibenzofurans" sponsored by Nat. Inst. Environ. Hit. Sci. Res. Triangle Park, N. Car. April, 1973. R&S162146 R vised 1/24/74