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PO LYM ER PRODUCTS DEPARTM ENT E X P E R IM E N T A L - S lA T lO N
PERSONAL AND COXK1DLNTIAL
3 . W. Kar rii L . J . Pa pa Pral File
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October 6, 1981
TO: DR. Y. L. POWER - FPL), Parkersburg FROM: S. S. STAFFORD
ANALYSIS OF BLOOD SAMPLES FOR PERFLU0R00CTAN0ATE (Job Wo. 810-578; PRAL Nos. 81-4178-4214; Notebook Nos. E22514.E26238)
As requested in your letter of 9/8/81 to L. J. Papa, the 37 blood samples submitted then have been analyzed for perfluorooctanoate (C,,) bv the
o usual gas chromatographic method ES-567. Results and sample identification are given in the attached table.
Attachment jah
Key Words: Perfluorooctanoate GC Blood Analysis
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TABLE 1 CONCENTRATION' OF PERFLUOROOCTAN0ATE IN BLOOD (a)
Sample PRAL No. Date Sampled
81-4178
8/25/81
81-4179
8/25/81
81-4180
8/25/81
81-4181
8/25/61
81-4182
8/25/81
81-4183
8/26/81
81-4184
8/26/81
81-4185
8/26/81
81-4186
8/27/81
31-4187
8/27/81
81-4188
8/27/31
81-4189
8/27/81
81-4190
8/28/81
31-4191
8/28/81
81-4292
8/28/81
81-4193
8/28/81
81-4194
8/28/81
81-4195
8/28/81
81-4196
8/28/81
81-4197
8/31/81
81-4198
8/31/81
81-4199
8/31/81
81-4200
8/31/81
81-4201
9/1/81
81-4202
9/1/81
81-4203
9/1/81
81-4204
9/1/81
81-42Q5
9/2/81
81-4206
9/2/81
31-4207
9/2/81
81-4208
9/2/81
P.R.No.
Name
GC Analysis_________________ _(b) Date Analyzed [Cr ], Ug F/k blood
9/28/81
0.58
9/28/81
0.63
9/25/81
0.24
9/28/81
0.12
9/28/81
0.4]
9/21/81
4.0
9/28/81
0.51
10/2/81
1.1
9/25/81
0.065
9/29/81
0.81
9/25/81
0.34
9/25/81
0.036
10/2/81
0.027
9/25/81
0.30
9/29/81
0.41
9/28/81
0.57
9/29/81
0.04t,
9/28/81
0.65
'28 5. 9/30/81
0.24
9/21/81
1.7
9/29/81
0.10
9/29/81
0.059
9/29/81
0.32
9/2L/81
4.4
9/29/81
0.21
9/30/81
0.17
9/30/61
0.21
9/30/81
0.33
9/30/SI
0.17
9/21/81
1.4
9/30/81
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TABLE I CONCENTRATION OF PERFLUOROOCIANOA_TE_ IN BLOOD la)
SanpIe PRAL No. Date Sampled ~ ~ T . R . ~ N o~.~
81-4209 81-4210 81-4211 81-4212 31-4213 81-4214
9/3/81 9/3/81 9/4/81 9/4/81 9/4/31 9/4/81
4409 3613 4479 757 4191 4275
CC Analysis Dat_e_ Analyzed
9/30/81 10/1 & 10/2/81 10/1 & 10/2/81
9/30/21 9/30/81 9/30/81
(b [Cr ], eg F/g blood
0.12 4.8 4.2 0.54 0.43 1.0
(a) Analysis as described in Lab Method ES-567 ("Determination of Perfluorooctanoic Acid in Blood, Gas Chromatographic Method", S. Stafford, 4/3/81), using the packed column GC analysis with perfluoro-n-octanoic acid as calibration standard.
(b) Although the analysis is specifically for perfluorooctanoate (acid or salts),
concentrations are given in ppm fluorine for comparison with the results of
total organic fluorine analyses. (ppm F = 0.688 x ppm perfluorooctanoic acid)
Estimated uncertainty is + 10% relative standard deviation. The lower limit
for quantitation is 0.007 ygF/g. The detection limit is ^ 0.004 vgF/g, but
concentrations in that range cannot be well quantitated and are reported as
[cg]< 0.007. None detected (n.d.) is reported for samples with
< 0.004 ppm.
which cannot be distinguished from reagent background.
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