Document oe5bq83vMVV23oq3bpa0YrmRo

DOCUMENT INFO Name: Location: Size: Modified: Comments: Shell Meeting - April 9, 2001.ppt Z:\Shanghai\Shell's position\ 87KB (88,064 bytes) Monday, April 9, 2001 3:29 PM PowerPoint could not open the file. (ErrCode=2147467259, Line=80, ProcName=Microsoft Office PowerPoint 2007) DOCUMENT INFO SH ELL-MCCLU RG-068083 Shanghai Health Study - Shell Discussion of Options Background: There has been a request for additional funding for the Shanghai Health Study. The current approved and funded budget is $26.4MM; the request for additional funding is approximately $10.1 MM. Shell's share would be $2MM. The 10.1 can be broken down into 3 components: Irons (U of Colorado) 7.4 Lab Transition 1.2 Other contracts 1.5 Options range from no additional funding to fully funding request. An analysis of benefitsiregrets: Options No additional $ Finish Study Fund lab transition Description When current funding Fund CC to x cases of Option runs out, analyze data and ME directed @ collected and publish lymphocytic effects Agree a max Increase Agree a max increase with a firm end date Fund request with goal to finish protocols Fund lab for continued diagnostics while new funds are identified Benefits Large case control cohort for AMLINHL, but short of protocols (500) Larger cohort for AMLINHL. Larger cohort for AMLIN HL. Larger cohort for AMLINHL. Benzene-induced MDS identified at high exposures ME most beneficial data ME most ME most beneficia beneficial data I data Nutritional anemias incorrectly diagnosed asAML Advanced the science in h 500 AMLINHL cohort for evaluating effects of benzene exposure Get relative risk for AMLINHL ME: Potential for better understanding of biomarkers of sure & effects SH ELL-MCCLU RG-068084 Options No additional $ Finish Study Fund lab transition Regrets Large investment for small return NHL ? not answered Do not finish Larger investment for a little more data May answer NHL question No dose response curve or threshold ctations stion May not get dose response curve or threshold Other Considerations: 1. Contract between Shell and API o Leave prior to completion - liable for share of full cost o Could change the scope, per Article 7, appendix A o Consortium can terminate work, per Article 6 o Put an absolute $ cap o Shell could agree to a "buy-out" of its share; i.e. Shell agrees to pay an additional amount and consortium agrees 2. Reputation Proposed changes that could be made: 1. Project management 2. QAlQC function increased 3. Grant with University of Colorado changed to a contract 4. Sponsors Executive Briefing by investigator Shell Next Steps: 1. Understand potential reputation impact 2. Brief key people in Chemicals 3. Develop Shell starting position with boundaries for upcoming consortium meeting 4. Engage with Shell outside Chemicals SH ELL-MCCLU RG-068085