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\\ *9 t d u c iti on DEPARTMENT WORKED BY AGE AND BY EDUCATION ax T - *.o.(n) 45.41 I 1.47(44) i 1236/237 T* o.e.(n) 43.20 - 1.60(56) < High School High School in d u ite Son College Collogo Cnduite 7 15.91 2 7 ' 61.36 10 22.73 -0 8 14.29 23 41.07 17 30.36 8 14.29 p -n lu e 0.3219 0.01 d p * 0.05 { PLAINTIFF'S i exhibit fo p V/fe/S. C2S621 \. I TABLE DEPARTMENT WORKED V OTHER DEPARTMENTS WORKED Worked in #262 Worked in #268 #236 (n*44) #% 12 27 .2 7 8 18.18 #236/237 (n*56) #% 7 12.50 2 3.57 p -v a lu e 0.0754 0.0203 I C2362U TABLE ____ DEPARTMENT WORKED v PREVIOUS EMPLOYMENT EXPOSURES P rev io u s Employment Exposures #236 (n-44) # % Yes #236/237 (n*56) # t Yes Q- v a l u e M echanical Work Fam ing Dust Solvents C utting 011s W e ld ln g /S o ld e rin g Fumes F ertilizer Weed K i l l e r A sbestos Animal Feed R adiation Rubber A d d itiv es 15 34.09 2 4.55 20 45.45 ~ 15 3 4 .09 10 22.73 13 29.55 5 11.36 ' 5 11.36 1 2.27 2 4.55 1 2.27 1 2.27 17 30.36 0 0.00 24 42.86 24 42.86 18 32.14 15 26.79 7 12.50 6 10.71 2 3.57 1 1.79 1 1.79 0 0.00 0.6911 0 .1 0 7 0 0.7951 0 .3 7 2 3 0.2979 0.7603 0.8622 0.9179 0.7055 0.4219 0.8629 0.2569 TABLE ____ DEPARTMENT WORKED v TOBACCO AND ALCOHOL USE Smoking S ta tu s Never F orm er P resen t (Unknown) . Alcohol S ta tu s ' Never Fortner P resen t Pack -Years* Former Smokers Pack Years P re s e n t Smokers Pack Years 1236 (n*44) # % Yes 14 32.56 11 25*58 18 41.86 O) 4 9.09 4 9.09 36 81*82 j t i i.e.(n ) 15.60 3.52(39) 13.56 - 3.66(9) 30.41 - 6 .5 5 (1 6 ) #236/237 (n*56) # % Yes p -v al ue 8 13 34 0) 14.55 23.64 61.82 0.0694 3 5.36 7 12.50 46 82.14 X s.e .(n ) 21.81 t 3.29(51) 17.31 - 5.00(13) 29.56 i 4.53(30) ' 0.6868 0.2045 0.5894 0.9167 C2 3 6 3 i ftartlv H istory Asthma H iy ftv tr Acne Eczema H ives TABLE DEPARTMENT WORKED v FAMILY HISTORY OF ILLNESS 236 (n*44) Yt 236/237 (n*56) S Th p-v ii ut 9 20.45 B 18.18 17 38.64 3 6.82 5 11.36 17 3 0 .3 6 16 2 8 .5 7 24 4 2 .8 6 3 5.36 3 5.36 0 .2 6 2 4 0 .2 2 7 2 0 .6 7 0 1 0.7601 0 .2 7 1 8 C 2 620 TABLE ____ DEPARTMENT WORKED v PERSONAL MEDICAL HISTORY #236 (n*44) Yes P ersonal M edical H isto ry Headaches High Blood P re s s u re B ronchitis Pnew onia P leurisy C hest Pain Kidney T rouble B ladder Trouble D iabetes T hyroid Problem s Stomach U lcer c o im s L iv e r Problem s A rth ritis Teenage Acne Skin B oils 26 59.09 11 2 5 .0 0 7 15.91 - 6 13.64 4 9.09 10 22.73 3 6.82 7 15.91 1 2.27 1 2.27 6 13.64 4 9.09 2 4.55 10 22.73 21 4 7 .7 3 17 38.64 #236/237 (n56) # % Yes P -value 29 51.79 12 2 1 .4 3 16 28.57 14 25.0CT 7 12.50 18 32.14 3 5.36 5 8.93 3 5.36 4 7.14 12 2 1 .4 3 2 3.57 3 5.36 18 32.14 17 30.36 IB 32.14 0.4661 0.6736 0 .1 3 5 3 0.1585 0.5886 0.2979 0.7601 0 .2 6 6 3 0.4346 0.2673 0.3140 0.2486 0 .6 5 3 3 0.2979 0 .0 7 5 7 0 .4 9 9 2 \` C23621 TABLE ____ DEPARTMENT WORKED v PERSONAL MEDICAL HISTORY 1236 1 % Yes #236/237 # % Yes p -v a lu e Poison Ivy/Oak H im O ther Rash Skin Cancer P ro state Canter 17 38.64 6 13.64 19 4 3 .1 8 2 4.55 1 2.27 17 30.36 8 14.29 25 44.64 0 0.00 0. 0.00 0.3856 0.9260 0.883B 0 .1 0 7 0 0.2569 C23627 v ita l Signs TABLE ____ DEPARTMENT WORKED v VITAL SIGNS #236 7 - s .t.(n ) #236/237 X - s .t.(n ) p -v a lu e Q uetelet Index (He1ght/W e1ght x 100) S y s t o l i c BP D i a s t o l i c BP P u lse R espiration H eight W eight Tem perature 36.26 - 0.63(44) 123.70 * 2.71(44) 75.66 t 1.63(44) 77.75 1.61(44) 19.86 i 0.60(43) 70.41 > 0 .4 7 (4 4 ) 198.60 4.97(44) 97.76 - 0.09(42) 36.60 - 0 .88(56) 0.0423 120.7 - 1.99(56) 72.50 - 1.36(56) 73.75 t 1.58(56) 18.85 - 0 .45(54) 69.34 - 0.31(56) 184.73 - 5 .08(56) 97.90 - 0.09(53) 0.3647 0.1398 - 0.0835 0.2523 0.0512 0.0547 0.2921 TABLE DEPARTMENT WORKED V DERMATOLOGIC FINDINGS teratologie Finding* CMoracne 236 1236/237 (n-44) (n-56) 1 U sl L L itt ' 30 45.45 22 39.29 p-m luo 0.5350 Twe Coatdonai C ystic P u stu lar S everity M ild M oderate L ocations T em poral Forehead M alar Cheeks O ccipital Neck Trunk S h o u ld e rs G enitalia 20 22 95 10 14 15 67 11 11 43 n 15 54 00 11 30 21 10 History only, Chloracne 10 13 -C23629 TABLE DEPARTMENTS WORKED DERMATOLOGICAL FINDINGS D erm atological F indings' #236 (n*44) TYes #236/237 (n*56) % Yes o -v a lu e A ctinic E lasto sls 5 11.36. S everity M ild M oderate Severe 3 2 0 Where Face Neck 5 2 Both Chloracne t A ctinic E lasto sls 3 6.82 M alar H irsutism 4 9.09 H isto ry Acne V u lg a ris 20 45.45 Acne V u lg aris 8 18.18 S everity M ild M oderate 7 1 F o llicu litis 4 9.09 A ctin ic K eratoses 1 2.27 Basal Cell E pitheliom a 0 0.00 Squamous C e ll E p ith e lio m a 0 D.DO S eborrheic D erm atitis 2 4.55 D erm atophytosls Hands Feet N alls O ther 1 12 3 5 P soriasis 0 0.00 A topic D erm atitis 0 0.00 7 12.50 0.8622 3 2 2 5 3 1 1.79 1 1.79 22 39.29 12 2 1 .4 3 0 .2 0 2 4 0.0961 0 .5 3 5 0 11 1 6 10.71 0.7B82 2 3.57 0 .7 0 5 5 0 0.00 0 0.00 -- 7 12.50 0.1677 0 18 3 7 0 0.00 1 1.79 0.3730 C2363U TABLE ____ DEPARTMENTS WORKED v DERMATOLOGICAL FINDINGS D eroatoloolcal Findings Poikiloderm a Face Neck Chest O ther #2 36 (n*44) L lL #236/237 (n*56) # Yes 00 01 00 01 C236 TABLE ____ DEPARTMENTS WORKED v DERMATOLOGICAL FINDINGS D erm atoloqlcal Findings D erm atofibrom a Lipoma P igm ented Nev1 R osacea/R h 1nophyma Lichen Simplex C hronicus A lopecia O ther Than P attern Baldness N eu rofibrom a Leukoderma P etech iae Ecchymoses Dupuytren*s C o n tractu re J u n c ti o n a l Nev1 L ym phadenopathy Livedo R e tic u la ris X erosis P ilonidal Cyst O titis Externa H iId C hronic D erm atitis X anthelasm a S eborrheic K eratoses #236 (n-44) X Yes 0 0.00 1 2.27 2 4.55 2 4.55 1 2.27 0 0.00 0 0.00 0 0.00 0 0.00 0 0.00 0 0.00 1 2.27 1 2.27 2 4.55 0 0.00 1 2.27 1 2.27 0 0.00 1 2.27 #236/237 (n*56) X Yes p -v a lu e 1 1.79 3 5.36 5 8.93 3 5.36 2 3.57 0 0.00 0.3730 0.4346 0.3938 0.8533 0.7055 0 0.00 0 0.00 1 1.79 1 1.79 1 1.79 1 1.79 1 1.79 2 3.57 0 0.00 1 1.79 0 0.00 1 1.79 7 12.50 -- 0 .3 7 3 0 0 .3 7 3 0 0.3730 0.8629 0.8629 0.8051 0.8629 0.2569 0 .3 7 3 0 0.0613 C2S632 TABLE ____ DEPARTMENTS WORKED v CLINICAL LABORATORY FINDINGS #236 lit.e .( n ) #236/237 y i s.e .(n ) p -v a lu e S o d lin K ag n eslu n P o ta ssiu m C hloride C alciu m Phosphorous Iron BUN C reatinine B U N /C reatin in e U ric Acid G lucose Total P rotein 139.16 0.42(44) 2.02 0.04(44) 4.45 0.06(44) 103.42 - 0.60(43) 9.72 0.06(44) 2.82 - 0.06(44) 107.68 - 4.19(44) 14.43 - 0.51(44) 1.33 - 0.03(44) 11.26 - 0.52(44) 6.14 - 0.20(44) 99.91 - 4.17(44) 7.79 i 0.07(44) 139.04 t 0 .3 1 (5 6 ) 2.01 0.02(56) 4.54 - 0.05(56) 103.68 - 0.41(56) 9.79 - 0.05(56) 2.85 - 0.05(56) 112.29 i 5 .4 1 (5 6 ) 15.43 - 0 .58(56) 1.29 - 0.03(56) 12.27 - 0.51(56) 6.26 - 0.21(56) 95.38 i 1.69(56) 7.59 - 0.07(56) 0.8102 0.7828 0.2298 0.7122 0 .3 3 4 0 0.6701 0.5207 0.2144 0.3721 0.1744 0.6959 0.2780 0.0504 C26633 TABLE ____ DEPARTMENTS WORKED v CLINICAL LABORATORY FINDINGS 236 X - s. .(n ) #236/237 X - s.e .(n ) A lburin G lobulin A lbw ln/G lobulln Total B iliru b in D irect B iliru b in SGOT SGPT GGTP A lkaline P h o sp h a ta se LDH 4.47 t 0.06(44) : 3.32 - 0.08(44) 1.39 i 0.04(44) 0.71 - 0.05(44) 0.21 - 0.02(44) 33.43 - 2.21(44) 42.14 i 2.41(44) 23.33 - 2.60(43) 30.00 - 1.21(44) 186.36 - 5.38(44) 4.44 t 0.04(56) 3.15 i 0.06(56) 1.43 - 0.03(56) 0.68 - 0.04(56) 0.18 - 0.01(56) 31.77 - 3.31(56) 44.41 5 .2 2 (5 6 ) 20.18 - 2.25(56) 32.02 J 1 .05(56) 175.55 i 3.55(56) !>v a lu e 0{6762 0.0814 0.3716 0.6770 0.2831 0.6940 0.7178 0.3619 0.2096 0.0858 WBC RBC HGB HCT HCV HCH MCHC TABLE _____ DEPARTMENTS WORKED CLINICAL LABORATORY FINDINGS #236 s.e .(n ) 6.70 i 0.27(42) 5.22 - 0.09(42) 15.94 0 .1 9 (4 2 ) 48.32 i 0.63(42) 92.83 i 0.71(42) 30.65 - 0.29(42) 33.01 - 0 .1 3 (4 2 ) #236/237 s.e .(n ) 7.25 - 0 .2 5 (5 6 ) 5.08 - 0 .0 4 (5 6 ) 15.61 - 0 .1 5 ( 5 6 ) 47.39 - 0 .4 2 ( 5 6 ) 93.36 - 0 .6 3 ( 5 6 ) 30.75 - 0 .2 3 ( 5 6 ) 32.93 - n . 1 1 (5 6 ) p-value 0.1430 0.1193 0.1727 0.2087 0.5732 0.7919 0.6454 TABLE ____ DEPARTMENTS WORKED v CLINICAL LABORATORY FINDINGS Polys (* ) Lym phocytes (X) M onocytes (X) E o s in o p h ils (X) B a s o p h ils (X) #236 X - s.e.(n ) 59.83 t 1.17(42) 30.02 - 1.07(42) 7.13 - 0.33(42) 2 .3 3 - 0.21(42} 0.70 > 0.09(42) #236/237 X - s.e.(n) 58.50 - 1.08(56) 31.21 - 1.03(56) 7 .2 8 - 0.29(56} 2.27 - 0.16(56) 0.74 - 0.05(56) p-v a lu e 0.4114 0.4310 0.7356* 0.8281 0.6106 c2663 3 TABLE DEPARTMENTS WORKED v CLINICAL LABORATORY FINDINGS Poly (Abs) Lymph (A bs) Mono (A bs) Eos (Abs) Easo (Abs) #236 J - s.e .(n ) #236/237 l i S.l!.(n ) p -v a lu e 7 6 .6 4 - 228.34(42) 1966.45 - 60.71(42) 462.93 - 22.49(42) 151.45 t 14.30(42) 45.10 i 5.81(42) 4313.23 - 202.36(56) 2195.43 t 77.70(56) 523.64 - 24.97(56) 163.43 - 12.49(56) 52.59 - 3.51(56) 0.4415 0.0469 0.0843 0.5301 0.2489 C2363 TABLE ____ DEPARTMENTS WORKED v CLINICAL LABORATORY FINDINGS BLOOD REFERENCE RANGE UNITS 236 T f i s . e . (n) #236/237 X i s.e .(n ) p -v a lu e T o tal L ip id s (gin/dL) C h o lestero l (g/dL) T rig ly c e rid e (mg/dL) T otal C holesterol (n g /d L ) C-HDL (itg /d L ) C-LOL ( r g /d L ) C-VLDL ( n g / d l ) 0.70 - 0.03(43) 245.80 - 8.09(44) 185.73 i 14.11(44) 242.19 i 7.96(43) 47.72 t 2.68(43) 157.49 - 6.85(43) 37.73 - 5.72(43) 0.65 - 0.02(56) 234.93 - 6.34(56) 179.98 - 12.20(56) 231.43 - 5.69(56) 45.93 - 2.48(56) 155.18 - 5.78(56) 30.93 - 2.29(56) 0.1853 0 .2 8 5 6 0.7177 0.2617 0.6269 0.7962 0.2273 C266 pH . S pecific G rivlty TABLEDEPARTMENTS WORKED v_ CLINICAL LABORATORY FINDINGS 236 T - .* .(n) 236/237 T - s.ft.(n ) p-v*1ue 5.28 - 0.08(43) 1.0224 - 0.0009(43) 5.29 * 0.07(55) 1.0235 * 0.0008(55) 0.9112 0.3746 C2 3 6 3 9 TABLE ____ DEPARTMENTS WORKED v_ CLINICAL LABORATORY FINDINGS BLOOD REFERENCE RANGE UNITS S odlun (wno 1 /L ) 134.00 - 146.00 Haoneslum (meg/L) < 1 .6 0 1.60 - 2.20 > 2.20 P o tassiu m (wno l / l ) 3.50 - 5.50 > 5 .5 0 C h lo rid e fumo 1 /L ) c 96.00 96.00 - 110.00 > 1 1 0 .0 0 Iron (ug/dL) < 45 .0 0 45.00 - 200.00 > 200.00 Calcium (m g/dl) < 8.80 8.80 - 10.80 Phosphorus (rog/dL) 2.00 - 4.70 BUN (m q /d l) < 6.00 6.00 - 25.00 > 2 5 .0 0 C re a tin in e (mg/dL) 0.50 - 1.70 235 I X Yes #235/237 i X Yes D * v alu e 44 100.00 0 0.00 37 84.09 7 15.91 43 97.73 1 2.27 0 0.00 42 97.67 1 2.33 56 100.00 T ------------ 2 3.57 48 85.71 6 10.71 0.3516 55 100.00 0 0.00 0.2569 2 3.57 54 96.43 0 0.00 0.2415 0 0.00 44 100.00 0 0.00 1 2.27 43 97.73 44 100.00 1 2.27 43 97.73 0 0.00 44 100.00 1 1.79 53 94.64 2 3.57 0.2967 0 0.00 56 100.00 0.2569 56 100.00 -- ------- 0 0.00 53 94.64 3 5.36 0.1609 55 100.00 -- C2364-0 TABLE ____ DEPARTMENTS WORKED v. CLINICAL LABORATORY FINDINGS BLOOD REFERENCE RANGE UNITS BUN/Creat1n1ne R atio 3,57 - 2 5 . U ric A d d (mg/dLj 2.50 - 8.50 > -8 .5 0 G lucose (mg/dL) 6 5 .00 - 130. oo >-130.00 T otal P ro te in (gm/dL) 6.60 - 8.90 #236 # % Yes #236/237 # % Yes p -v a lu e 44 100.00 42 95.45 2 4.55 42 95.45 2 4.55 44 100.00 56 100.00 50 89.29 6 10.71 0 .2 5 9 0 55 98.21 1 1.79 0.4219 56 100.00 ---- C28641 table'___ DEPARTMENTS WORKED v CLINICAL LABORATORY FINDINGS BLOOD REFERENCE RANGE UNITS #236 # % Yes Albumin (gm/dL) * 3 .6 0 3.60 - 5.20 > 5 .2 0 1 2.27 42 95.45 1 2.27 G lo b u lin (gm/dL) 1.90 - 3.70 > 3 .7 0 36 81.82 8 18.18 A lbunrtn/GlobuHn R atio 0.46 - 2.63 44 100.00 T o ta l B ilir u b in (mg/dL) 0 .1 0 - 1.70 > 1 .7 0 43 97.73 1 2.27 D ire c t B ilir u b in (mg/dL) 0.0 0 - 0.30 > 0 .3 0 41 9 3 .1 8 3 6.82 T ra n s a m in a s e , SGO (IU /L ) 1.00 - 50.00 > 5 0 .0 0 40 90.91 4 9.09 T ra n s a m in a s e , SGP (IU /L ) 1 .0 0 - 70.00 > 7 0 .0 0 40 90.91 4 9.09 G -glutam yl T ra n sp e p tid a se (U/L) 1 .0 0 - 70.00 > 7 0 .0 0 42 97.67 1 2.33 A lk alin e Phosphatase (IU /L) 10.00 - 50.00 > 50.00 43 97.73 1 2.27 LDH (IU /L ) 9 0 .0 0 - 2 5 0 .0 > 250.00 42 9 5 .4 5 2 4.55 #236/237 # X Yes p -v a lu e 0 0.00 56 100.00 0 0.00 0.2729 50 89.29 6 10.71 0 .2 8 5 4 56 100.00 55 98.21 1 1.79 0.6629 52 92.86 4 7.14 0.9496 52 92.86 4 7.14 0.7215 52 92.86 4 7.14 0.7215 55 98.21 1 1.79 0.8499 55 98.21 1 1.79 56 100.00 0 0.00 0.1070 C26642 TABLE ____ DEPARTMENTS WORKED v CLINICAL LABORATORY FINDINGS BLOOD REFERENCE RANGE UNITS RBC (m lV H o n s/c u .g ffi.) ^ 4.6 4.6 - 6.2 y 6,2 H em oglobin (^gm/dL.) -= 1 4 .0 14.0 - 18.00 > 18.00 H em atocrit (p ercen t) * 4 2 .0 0 42.00 - 54.00 * 5 4 .0 0 HCV ( c u . j ) * 8 0 .0 0 80.00 - 100.00 > 1 0 0 .0 0 HCH * 26.00 26.00 - 33.00 > 33.00 MCHC ( p e r c e n t ) * 31.00 31.00 - 36.00 #236 # Yes #236/237 # % Yes D -value 2 4.76 39 9 2 .8 6 1 2.38 0 0.00 39 92.86 3 7.14 3 5.36 53 94.64 0 0.00 0.5071 3 5.36 53 94.64 0 0.00 0 .0 4 3 8 0 0.00 41 9 7 .6 2 1 2.38 3 5.36 52 92.86 1 1.79 0 .3 0 9 0 0 0.00 41 9 7 .6 2 1 2.38 1 1.79 51 9 1 .0 7 4 7.14 0.3817 1 2.38 36 85.71 5 11.90 1 1.79 52 92.86 3 5.36 0.487} 1 2.38 41 9 7 .6 2 1 1.79 55 98.21 0.8366 C2364 TABLE ____ DEPARTMENTS WORKED v CLINICAL LABORATORY FINDINGS BLOOD REFERENCE RANGE UNITS #236 # % Yes CSC WBC (th o u s a n d /c u .m n .) 4 .0 0 - 11.60 > 11.60 41 9 7 .6 2 1 2.38 D iffe re n tia l Polys (p ercen t) * 4 2 .0 42.0 - 81.0 7 81.0 0 0.00 42 100.00 0 0.00 Lymphocytes (p e rc e n t) 10.0 - 47.0 > 4 7 .0 42 100.00 0 0.00 Monocytes (p e rc e n t) 0 .0 - 10.0 7 -1 0 .0 38 90.48 4 9.52 E osinophils (percen t) 0 .0 - 8.0 42 100.00 B asophils (p ercen t) 0.0 - 2 .0 > 2 .0 41 9 7 .6 2 1 2.38 #236/237 # % Yes D -vil ue 84 96.43 2 3.57 0.7349 2 3.57 84 96.43 0 0.00 0.2159 54 96.43 2 3.57 0.2159 51 9 1 .0 7 5 8.93 0.9196 56 100.00 -- 56 100.00 0 0.00 0 .2 4 5 8 C2 0 6 3 4 TABLE ____ DEPARTMENTS WORKED v CLINICAL LABORATORY FINDINGS BLOOD REFERENCE RANGE UNITS . #236 # % Yes CBC D ifferential A bsolute Values ( c e lls /c u .n n .j N eutrophils 1650 - 6330 >8330 L ym phocytes *1049 1049 - 3581 >3581 M onocytes 61 - 929 >929 E osinophils *40 40 - 423 B asophils *10 10 - 148 >148 41 97*62 1 2.38 1 2.38 41 9 7 .6 2 0 0.00 42 100.00 0 0.00 3 7.14 39 92 .6 6 2 4.76 39 92.86 1 2.38 #236/237 # % Yes p -v a lu e 55 98.21 1 1.79 0.8366 0 0.00 54 96.43 2 3.57 0.2421 55 98.21 1 1.79 0.3840 2 3.57 54 96.43 0.4265 1 1.79 55 98.21 0 0.00 0.3500 C2-36I5 table DEPARTMENTS WORKED v CLINICAL LABORATORY FINDINGS BLOOD REFERENCE RANGE UNITS #235 # % Yes #236/237 # % Yes o -v a lu e T o ta l L ip id s (om/dL) 0.30 - 1.00 >1*00 C h o le ste ro l (mg/dL) -=125 125 - 300 7*300 T rig ly c e rid e ng/dL) 50 - 200 >200 T o ta l C h o le ste ro l (pig/dL) ^ 125 125 - 300 >300 C-HDL (m g/dL) ^30 3 0 -7 5 >75 C-LDL (oe g/dL) -=60 60 - 185 >185 C-VLDL (mq/dL) 0 .0 - 40.0 > 4 0 .0 41 9 5 .3 5 2 4.65 1 2.27 36 81.62 7 15.91 30 6 8 . IB 14 31.82 1 2.33 36 83.72 6 13.95 7 16.28 34 79.07 2 4.65 1 2.33 30 6 9 .7 7 12 27 .9 1 31 7 2 .0 9 12 2 7 .9 1 55 98.21 1 1.79 0.4097 0 0.00 46 82.14 10 17.86 0 .5 1 4 8 39 69.64 17 30.36 0.8754 0 0.00 52 92.86 4 7.14 0.2661 n 19.64 42 75.00 3 5.36 0.8923 0 0.00 44 78.57 12 2 1 .4 3 0 .3 7 2 4 46 82.14 10 17.86 0.2332 C266-40 TABLE DEPARTMENTS WORKED v CLINICAL LABORATORY FINDINGS U rinalysis A ppearance C lear S p ecific 6rav1t 1.008 - 1.036 A ceto n e N egative 1+ Albumin N egative C lu co se N egative 2+ Blood N egative WBC N egative 0 -2 2 -5 5-10 ' RBC N egative 0 -2 C asts N egative B acteria None S lig h t M oderate #236 I X Yes 3 6 /2 3 7 % Yes p -v a lu e 43 100.00 55 100.00 -- -- 43 100.00 55 100.00 -- 43 100.00 0 0.00 54 98.18 1 1.82 0.3741 43 100.00 55 100.00 42 97.67 1 2.33 43 100.00 53 . 96.36 2 3.64 0 .7 0 8 55 100.00 34 79.07 5 11.63 2 4.65 2 4.65 42 97.67 1 2.33 40 72.73 6 10.91 9 16.36 0 0.00 55 100.00 0 0.00 0.2556 4 3 1 0 0 .0 0 55 100.00 39 90.70 3 6.98 1 2.33 48 87.27 7 12.73 0 0.00 0.3512 G 2664 7 ~} TABLE DEPARTMENTS WORKED v CLINICAL LABORATORY FINDINGS #236 ii 1236/237 ii try sa il Moot U ric A cid C alrfiai O xalate 42 #7.67 0 0.00 1 2.33 64 98.18 0 0.00 1 1.82 0.8601 Y east N egative H .5 6 7 43 100.00 $5 100.00 - 32 74.42 10 23.26 1 2.33 41 74.55 12 21.82 2 3.64 0 .9 2 4 2 5t. > ;% ramBM W immifcwiiiujui C2*364 8 ( Age TABLE _____ 2 6 2 /2 6 8 EXPOSURE v DEMOGRAPHIC INFORMATION EVER IN DEPARTMENT 262 OR 268? wo x 1 . .(") 43.09 * 1.36(76) TCS X 1 t.t.(n ) 47.68 1 1.46(24) P -V llut 0.0276 Education < High School High School G raduate Sone C ollege College Graduate* X 11 14.47 35 46.05 22 28.95 B 10.53 t 4 16.67 15 62.50 5 20.83 0 0.00 0.25 p< TABLE____ 262/268 EXPOSURE v OTHER DEPARTMENT WORKED EVER IN DEPARTMENT 262 OR 268? Ever in 237? NO n=76 #% 47 61.84 YES n=24 #% p-value 9 37.50 0.0579 C2S702 TABLE ____ 262/268 EXPOSURE v PREVIOUS EMPLOYMENT EXPOSURES EVER IN DEPARTMENT 262 OR 268? PREVIOUS EMPLOYMENT EXPOSURES 4 No (n-76) 1* M echanical Work 27 35.53 Fanning 2 2.63 D ust 30 39.47 S o lv e n ts 33 43.42 C utting O ils W elding/Soldering Fines F ertilizer 26 34.21 22 28.95 10 13.16 Weed K i l l e r 11 1 4 .4 7 A sbestos Animal Feed 2 2.63 2 2.63 R adiation Rubber A dditives 1 1.32 1 1.32 Yes (n24) 1! 5 20.83 0 0.00 14 58.33 6 25.00 2 8.33 6 25.00 2 8.33 0 0.00 1 4.17 1 4.17 1 4.17 0 0.00 p-value* 0.2163 1.0000 0 .1 5 6 3 0.1500 0.0175 0 .7 9 8 7 0 .7 2 5 5 0 .0 6 1 5 0.5652 0.5652 0 .4 2 4 2 1.0000 C2G70 TABLE ____ 262/268 EXPOSURE v TOBACCO AND ALCOHOL USE EVER IN DEPARTMENT 262 OR 2687 Alcohol S ta tu s Never Former P resen t Smoking S ta tu s Never Former P re se n t (Unknown) P ick Years No t Yes Yes % Yes p -v a lu e 5 6.58 B 10.53 63 82.89 2 8.33 3 12.50 19 7 9 .1 7 0.9159 18 24.00 17 22.67 40 53.33 1 X i s.e .(n ) 17.74 i 2.69(69) 4 17.39 7 30.43 12 5 2 .17 1 T i s.e .(n ) 23.67 5.37(21) 0.6768 0.3021 02570 TABLE ____ 262/268 EXPOSURE v FAMILY HISTORY OF ILLNESS EVER IN DEPARTiENT 262 OR 268? Fam ily H isto ry Asthma H ayfever Acne . Eczema H ives No (n76) # X Yes 18 23.68 20 26.32 31 40.79 3 3.95 6 7.89 Yes (n*24) - # % Yes B 33.33 4 16.67 10 41.67 3 12.50 2 B.33 * by F is h e r 's Exact t e s t rv a lu e 0.4245 0.4190 1.0000 0.1476 1.0000 C2670 TABLE ____ 262/268 EXPOSURE 1 PERSONAL K O I CAL HISTORY EVER IN DEPARTMENT 262 OR 2687 P ersonal M edical H isto ry * No (n-76) * Yes Yes (n-24) * Yes p-val ue tteadaches High Blood P re ssu re B ronchitis Pneumonia P leurisy Chest Pain Kidney T rouble Bladder Trouble D iabetes T hyroid Problem s Stomach U lcer C o litis L iver Problem s A rth ritis Teenage Acne Skin B o lls Poison Ivy/Oak H iv es O th e r R ash , Nos Skin Cancer P rostate Cancer ` Includes unconfirm ed 42 55.26 13 54.17 1.000 14 1 8 .4 2 9 3 7 .5 0 0.0920 16 21.05 7 29.17 0.4155 16 21.05 4 16.67 0.7747 8 10.53 3 12.50 0.7224 21 27.63 7 29.17 1.0000 3 3.95 3 12.50 0.1476 9 1 1 . B4 3 1 2 .5 0 1.0000 1 1.32 3 12.50 0.0419 3 3.95 2 8.33 0.5910 15 19.74 3 12.50 0.5502 4 5.26 2 B.33 0 .6 2 8 0 2 2.63 3 12.50 0.0679 18 23.68 10 41.67 0.1175 30 39.47 8 33.33 0.6375 27 35.53 8 33.33 1.0000 28 36.84 6 25.00 0.3320 11 14.47 3 1 2 .5 0 . 1.0000 31 40.79 13 54.17 0.3457 1 1.32 1 4.17 0.4242 1 1.32 0 0.00 1.0000 TABLE ____ 262/268 EXPOSURE v_ VITAL SIGNS EVER IN DEPARTMENT 262 OR 268? V ital Signs Q uetelet Index (H eight/W eight x 100) S y s t o l i c BP D i a s t o l i c BP P u lse R espiration H eight H eight Tem perature No X t s.e .(n ) 37.99 t 0.72(76) 122.00 t 1.86(76) 73.58 t 1.29(76) 75.17 1 1.34(76) 19.40 t 0.54(73) 69.79 * 0.31(76) 189.28 t 4.17(76) 97.87 t 0.07(74) Yes x t s.e .(n ) 36.69 t 1.25(24) p -v a lu e 0.3733 122.13 1 3 .43(24) 74.88 1 1.71(24) 76.58 t 2.21(24) 19.00 t 0.67(24) 69.88 t 0.60(24) 196.13 t 7 .5 1 (2 4 ) 97.70 1 0.15(21) 0.9740 0.6040 'G .6 0 1 6 0.6962 0.8943 0.4244 0 .2 6 6 3 C2670V TABLE ____ 262/268 EXPOSURE v CHLORACHE EVER IK DEPARTMENT 262 OR 268? C h lo ra cn e Comedna l C ystic P ustular S e v e rity M ild M oderate S ite Temporal Forehead M alar Cheeks O ccipital Neck Trunk S h o u ld e rs G enitalia D erm atologist H istory o f Chloracne * by Fisher's Exact Test No (n-76) % 33 43.42 33 10 1 Yes (n*24) #% 9 37.50 9 4 0 * p -v a lu e 0.6436 23 6 10 3 16 6 70 22 4 72 00 20 21 12 i0 49 64.47 16 66.67 1.0000 C2S708 TABLE ____ 262/268 EXPOSURE v DERMATOLOGIC FINDINGS EVER IN DEPARTMENT 262 OR 268? Dermatologic F indings No (n --7 6 ) A ctinic E la sto sis S everity M ild M oderate Severe Where Face Neck Both C hioracne and A ctinic E la sto sis 9 11.84 4 3 2 7 5 3 3.95 M alar H irsu tism H is to ry Acne V u lg a ris Acne V u lg a ris S e v e rity M ild M oderate F o llicu litis A ctinic K eratoses Basal C ell E pitheliom a Squamous C e ll E p ith e lio m a Seborrheic D erm atitis D erm atophytosis Hands Feet N ails O ther P s o r i a s i s A topic D erm atitis Poikiloderm a 2 2.63 34 44.74 18 23.68 16 2 9 11.84 2 2.63 0 0.00 0 0.00 6 7.89 1 1.32 23 30.26 3 3.95 9 11.64 0 0.00 1 1.32 Face Neck Chest O ther D erm atofibrom a Lipoma Pigmented Nevi R osacea/R hlnophym a 0 0.00 0 0.00 0 0.00 1 1.32 0 0.00 4 5.26 3 3.95 3 3.95 Yes (n*24) 3 12.50 2 1 0 3 0 1 4.17 3 12.50 8 33.33 2 8.33 2 0 1 4.17 1 4.17 0 0.00 0 0.00 3 12.50 0 0.00 7 29.17 3 12.50 3 12.50 0 0.00 0 0.00 * 1 4.17 0 0.00 0 0.00 0 0.00 1 4.17 0 0.00 4 16.67 2 8.33 p -v a lu e 1.0000 1.00DJ) O.OB79 0.3537 0.1445 0.4437 0.5652 0.4449 1 .0 0 0 0 1 .0 0 0 0 0.1476 1.0000 1 .0 0 0 0 0.2400 1.0000 0.2400 0.5697 0.0549 0.5910 f 30 0 TABLE ____ 262/268 EXPOSURE v DERMATOLOGIC FINDINGS Dermatoloqic Findings EVER IN DEPARTMENT 262 OR 268? No Yes # r"Yes # T T e s Lichen Simplex Chronicus Alopecia Other than Pattern Baldness Neurofibroma Leukoderma Petechiae Ecchymoses Dupuytren's Contracture Junctional Nevi Lymphadenopathy Livedo Reticularis Xerosis Pilonidal Cyst Otitis Externa Mild Chronic Dermatitis Xanthelasma Sebor-rheic Keratoses 2 2.63 0 0.00 0 0.00 0 0.00 0 0.00 1 1.32 1 1.32 2 2.63 2 2.63 4 5.26 0 0.00 1 1.32 1 1.32 1 1.32 5 6.58 1 4.17 0 0.00 0 0.00 0 0.00 0 0.00 0 0.00 0 0.00 0 0.00 0 0.00 0 0.00 0 0.00 1 4.17 0 0.00 0 0.00 3 12.50 p-value 0.5652 -- 0.2400 1.0000 1.0000 1.0000 1.0000 0.5697 0.4242 1.0000 1.0000 0.3938 C2710 TABLE ____ 262/268 EXPOSURE 1 CLINICAL LABORATORY FINDINGS EYER IK DEPARTiCNT 262 OR 268? S{aogdeiiaaadjusted) rtagneslt* (age adjusted) Potassium (age adjusted) Chloride (age adjusted) Calcium (age adjusted) Phosphorous (age adjusted) Iron (age adjusted) fage adjusted) Creatinine (age adjusted) BUN/Creatlnine (age adjusted) Uric Acid (age adjusted) Glucose (age adjusted) Total Protein (age adjusted) Albumin (age adjusted) Globulin (age adjusted) Albumln/GTobulln (age adjusted) Total Bilirubin (age adjusted) Direct Bilirubin (age adjusted) Wo i i a.e.(n) 139.11 t 0.30(76) 139.13 Z 0.29 2.02 t 0.02(76) 2.02 * 0.02 4.49 % (U>5(76) 4.50 i 0.05 103.95 t 0.38(76) 103.95 Z 0.39 9.76 t 0.04(76) 9.76 Z 0.04 2.84 1 0.04(76) 2.84 t 0.04 111.51 t 4.31(76) 110.54 Z 3.94 14.78 % 0.45(76) 14.81 Z 0.46 1.31 t 0.03(76) 1.31 * 0.02 11.60 t 0.41(76) 11.62 * 0.43 6.19 1 0.16(76) 6.20 Z 0.17 95.33 t 1.37(76) 95.80 Z 2.30 7.69 t 0.06(76) 7.69 : 0.06 4.46 t 0.04(76) 4.45 Z 0.04 3.24 t 0.06(76) 5.24 r 0.06 1.42 t 0.03(76) 1.41 I 0.03 0.70 t 0.04(76) 0.70 : 0.04 0.19 t 0.01(76) 0.19 Z 0.01 Yes X + s.e.(n) 139.04 1 0.49(24) 138.98 I 0.53 -1.99 * 0.04(24) 1.98 Z 0.04 4.52 * 0.09(24) 4.51 Z 0.08 102.30 * 0.77(23) 102.28 * 0.72 9.75 0.07(24) 9.75 Z 0.08 2.81 0.06(24) 2.82 Z 0.08 106.29 J 5.65(24) 109.37 Z 7.07 15.67 1 0.84(24) 15.57 Z 0.82 1.28 Z 0.03(24) 1.27 t 0.04 12.53 1 0.80(24) 12.47 Z 0.76 6.27 t 0.31(24) ' 6.22 Z 0.30 103.83 * 7.41(24) 102.35 Z 4.13 7.63 0.10(24) 7.64 I 0.11 4.43 * 0.04(24) . . 4.46 I 0.07 3.20 1 0.08(24) 3.19 Z 0.10 1.41 * 0.03(24) 1.42 I 0.05 0.67 * 0.04(24) 0.67 Z 0.06 0.19 t 0.01(24) 0.19 Z 0.02 value 0.9152 0.8040 0.6469 0.3651 0.7865 0.9331 0.0448 0.0459 0.8360 0.9173 0.6749 0.8045 0.5309 0.8854 0.3408 0.4195 0.4348 0.3860 0.2875 0.3402 0.8168 0.9520 0.0785 0.1710 0.5842 0.7057 0.7601 0.9238 0.7324 0.6543 0.8824 0.9404 0.6088 0.6783 0.7191 0.8097 TABLE ____ EVER IN DEPARTMENT 262 o r 268? SGQT (age adjusted) S6PT (age adjusted) SGTP (age ad justed) No X 1 s.e .(n ) 33.12 i 2.68(76) 33.48 i 2.38 45.13 t 3.96(76) 45.58 i 3.55 22.27 t 2.05(75) 22.53 i 1.95 A U alin e Phosphatase (age adjusted) LDH (age adjusted) 31.74 1 0.92(76) 31.82 t 0.91 180.83 t 6.20(76) 180.72 t 3.63 Yes X 1 s.e .(n ) 30.54 t 1.84(24) 29.39 i 4.28 37.96 t 2.91(24) 36.54 ! 6.37 19.29 1 2.90(24) 18.48 i 3.48 29.21 t 1.52(24) 28.94 1 1.63 178.67 i 4 .4 9 (2 4 ) 179.02 t 6.51 p -v a lu e 0.6000 0.4082 0.3256 0.2209 0.4565 0.3159 n.1758 0.1298 0.7692. 0.8207! TABLE ____ 262/268 EXPOSURE v CLINICAL LABORATORY FINDINGS EVER IN DEPARTMENT 262 OR 268? WBC (age adjusted) RBC (age adjusted) HGB (age ad ju sted ) HCT (g adjusted) HCV (age adjusted) MCH (age adjusted) MCHC (age adjusted) NO T - s.e.(n) 6.96 0.21(74) 7.00 * 0,21 5.13 t 0.06(74) 5.14 * 0.05 15.71 t 0.14(74) 15.72 t 0.14 47.72 t 0.44(74) 47.77 + 0.42 93.12 t 0.56(74) 93.18 0.54 30.68 t 0.22(74) 30.69 t 0.21 32.94 t 0 .10(74) 32.92 + 0.10 Yes li.e.(n) 7.20 1 0.37(24) 7.05 0.37 5.16 1 0.06(24) 5.15 0.09 15.88 t 0.21(24) 15.84 i 0.25 48.02 t 0.58(24) 47.B5 1 0.7 4 93.17 0.85(24) 93.00 Z 0.96 30.79 0 .29(24) 30.76 0.37 33.05 % 0.15(24) 33.09 0.17 p-value 0.5633 0.9050 0.8193 0.9328 0.5528 0.6712 0.7199 0.9222 -.0 .9 5 9 2 0.8730 0 .7 9 k ) 0.8581 0.5663 0.4174 . TABLE ____ 262/268 EXPOSURE v_ CLINICAL LABORATORY FINDINGS EVER IN DEPARTMENT 262 OR 268? Poly (*) (age ad ju sted ) Lym phocytes (3) (age adjusted) M onocytes (X) (age adjusted) E o s in o p h ils (X) (age adjusted) B a so p h ils (X) (age adjusted) Ho X - s,e.(n) 58.51 Z 0.94(74) 58.64 Z 0.91 31.31 Z 0.69(74) 31.18 Z 0.85 7.30 Z 0.25(74) 7.31 Z 0.25 2.14 t 0.14(74) 2.13 Z 0.15 0.74 Z 0.06(74) 0.74 Z 0.05 Yes X * s.e.(n) 60.80 * 1.42(24) 60.40 I 1.61 28.BOZ 1.27(24) 29.20 Z 1.50 6.95 Z 0.46(24) 6.92 I 0.44 2.78 % 0.27(24) 2.81 Z 0.26 0.67 1 0.07(24) 0.67 I/ 0.09 p-valuc 0.2168 0.3486 0.1471 0.2S65 0.4828 0.4460 J 0.0310 , 0.0247.:'; 0.4922 : 0.5203 C2S714 . TABLE ____ 262/268 EXPOSURE v CLINICAL LABORATORY FINDINGS EVER IN DEPARTMENT 262 OR 268? Poly (Abs) (ge adjusted) Lymph (Abs) (age Adjusted) Hono (Abs) (age adjusted) Eos (Abs) (age adjusted) Baso (Abs) (age adjusted) ho X1 s.e.(n) 4137.05 1 176.90(74) 4175.88 Z 170.50 2119.23 t 67.00(74) 2125.28 Z 66.27 501.54 Z 21.03(74) 504.88 I 19.97 145.89 t 10.37(74) 145.90 Z 10.64 50.07 Z 3.81(74) 50.28 I 3.73 Yes Xi s.e.(n) 4442.42 Z 290.32(24) 4322.71 Z 302.03 2029.67 Z 109.98(24) 2011.00 Z 117.40 485.54 * 29.66(24) 475.25 Z 35.37 196.54 * 19.42(24) 196.52 Z 18.85 47.25 Z , 5.84(24) 46.59 Z 6.61 P-value 0.3878 0.6749 0.5034 0.4017 0.6948 0.4703 0.0194 0.0223 0.7073 0.6296 C237iO . TABLE ____ 262/268 EXPOSURE v CLINICAL LABORATORY FINDINGS EVER IN DEPARTMENT 262 OR 268? T o ta l L ip id s (gm/dL) (age adjusted) C h o le stero l (wg/dL) (age adjusted) T rig ly c e rid e (mg/dL) (age adjusted) T o ta l C h o le ste ro l (mg/dL) (age adjusted) C-HDL (mg/dL) (age adjusted) C-LDL (mg/dL) (age adjusted) C-VLDL (m g/dL) (age adjusted) No X 1 s.e .(n ) 0.67 1 0.02(75) 0.67 t 0.02 239.09 t 6 .2 0 (7 6 ) 2 4 0 .1 8 * 5 . 71 186.28 t 10.79(76) 187.52 Z 10.57 235.11 1 5 .98(75) 236.09 1 5.40 47.08 t 2.10(75) 46.86 1 2.10 154.29 t 5.41(75) 155.18 1 5.02 34.33 - 3.60(75) 34.82 i 3.22 Yes X 1 s.e .(n ) 0.67 t 0.03(24) 0.66 5 0.04 241.67 ; 7 .50(24) 238.23 I 10.24 172.42 1 17.51(24) 168.49.1 18.96 239.21 t 5 .77(24) 236.14 1 9.63 45.54 t 3.66(24} 46.23 t 3.74 162.08 1 6.63(24) .159.31 1 8.95 32.58 1 2.87(24) 31.05 1 5.75 p -v a tu e 0.9766 0.7281 0.8282 0.8692 0.5224 0.3857 0.7122 0.9963 0. 8 4 0 .8 8 4 5 0 .4 5 0 9 0 .6 9 0 2 0.7908 0.5702 . P O C H ' ' i'T 0 ^ *V> t . TABLE ____ 262/268 EXPOSURE v CLINICAL LABORATORY FINDINGS EVER IN DEPARTMENT 262 OR 268? pH (ye adjusted) Specific Cravtty (age adjusted) No X t s.e.(n) 5.52 2 0.06(74) 5.32 i 0.06 1.0235 2 0.0007(74) 1.0234 2 0.0007 Yes Xt s.t.(n) 5.17 * 0.08(24) 5.19 1 0.11 1.0214 2 0.0013(24) 1.0216 - 0.0013 P-vilue 0.1964 0.3103 0.1374 0.2139 t < i X it; Blood *#fertnct Bsnw Units TABLE 262/268 EXPOSURE V. CLINICAL LABORATORY FINDINGS EVER IN DEPARTMENT 262 OR 268? Bo # lil t -Vllt* * Sodlum(wnoVL) 4.00 - 146.00 Uijnes1un{eg/!J 1.60 1.60 - 2.20 > 2.20 76 100.00 24 100.00 2 2.63 0 0.00 64 64.21 21 87.50 10 13.16 3 12.50 -- 0.7186 Bot*ss1u(TOVL) 3.60 - 5.50 > 5.50 CMorlde(wnoVL) < 16.00 *6.00 - 110.00 > 110.00 Cilduwfwg/dl) <1.80 $.80 - 10.80 fhosphorus(wg/dL) 2.00 - 4.70 75 98.68 24 100M 1 1.32 0 0.00 1.0000 2 2.63 0 0.00 73 96.05 23 100.00 1 1.32 0 *0.00 1 1.32 0 0.00 75 98.68 24 100.00 0.6262 1.0000 76 100.00 24 100.00 -- Iron (ug/dL) < 45.00 45.00 - 200.00 200.00 1 1.32 0 0.00 73 96.05 24 100.00 2 2.63 0 0.00 0.6136 $UN(*g/dL) <6.00 6.00 - 25.00 >25.00 1 1.32 0 0.00 73 96.05 23 95.83 2 2.63 1 4.17 0.7949 Crtitlnlnefap/dL) 0.50 - 1.70 76 100.00 24 100.00 ...... BW/Creatlnlne Rt1o 1.57 - 25.45 OHc Aeid(*g/dL) 2.50 - 8.50 > 8.50 76 100.00 24 100.00 70 6 92.11 7.69 22 2 91.67 6.33 1.0000 ~4T a ct fnr 2x2 tables; by chi-square test for 3x2 tables.  TABLE ____ 2 6 2 /2 6 8 EXPOSURE v CLINICAL LABORATORY FINDINGS Hood Reference Ranqe U n its EVER IN DEPARTMENT 262 OR 268? No Yes till P~v*1u* * 61ucose(m g/dL ) 65.00 - 130.00 > 130.00 i Total Prote1n(qm /dl) 6.60 - 8.90 A1bum1n(pm/dL) < 3.60 3.60 - 5.20 > 5.20 6lobuT 1n{gm /dL ) 1.90 - 3.70 > 3.70 Albumln/GlobuHn R atio 0.46 2.63 75 98.68 22 91.67 1 1.32 2 8.33 76 100.00 24 100.00 1 1.32 0 0.00 74 97.37 24 100.00 1 1.32 0 , 0.00 0.1422 0 .7 2 4 5 64 8 4 .2 1 22 9 1 .6 7 12 1 5 .7 9 2 8 .3 3 0.5081 76 100.00 24 I M .W T " ' T otal B iH rub1n(m g/dl) 0.10 - 1.70 > 1.70 D irect 8iI1rubIn(m q/dL) 74 97.37 24 100.00 2 2.63 0 0.00 0.00 - 0.30 > 0.30 70 92.11 23 95.83 6 7.69 1 4.17 T ransam inase, SG0(IU/L) 1.00 - 50.00 >50.00 ' 70 92.11 22 91.67 6 7.89 2 8.33 Transam inase, S 6P (ID /l) 1.00 - 70.00 > 7 0 .0 0 tilu ta n iy l Transpept1dasefU /L J 1.00 - 70.00 > 70.00 69 7 74 1 AHlit ne Phosphatasefl/Ll 10.00 - 50.00 > 50.00 74 2 U ttU U /L) 0.00 - 250.00 > ocn on 74 2 90.79 9.21 98.67 1 .3 3 97.37 2 .6 3 97.37 2.63 23 95.83 1 4.17 23 95.83 1 4.17 24 100.00 0 0.00 24 100.00 0 0.0 1.0000 1 .0 0 0 0 1 .0 0 0 0 0 .6 7 5 8 0 .4 7 8 0 1.0000 1.0000 C 26719  TABLE ____ 262/268 EXPOSURE v CLINICAL LABORATORY FINDINGS EVER IN DEPARTMENT 262 OR 268? Hood R eference Rinpe U n its RBC(11H onx/cu.w n.) <4.6 4.6 - 6.2 >6.2 H em oglob1n(pm /dL ) < 14.0 14.0 - 18.00 > 1 8 .0 0 H em atocrit(p e rc e n t) < 42.00 42.00 54.00 > 54.00 M C V (cu.u) < 80.00 80.00 - 100.00 > 100.00 CHfyyal < 26.00 26.00 - 33.00 > 33.00 M C H C (percent) < 31.00 31.00 - 36.00 Ho 4% Yes #* p-value * 4 5.41 1 4.17 69 93.24 23 95.83 1 1.35 0 0.00 0 .8 2 2 1 2 2.70 1 4.17 69 93.24 23 95.83 3 4.05 0 0.00 0.5733 2 2.70 1 4.17 70 94.59 23 95.63 2 2.70 0 0.0 0 1 1.35 0 0.0 0 68 9 1 .8 9 24 10 0 .0 0 5 6.76 0 0.00 0.6776 .. 0.3547 2 2.70 0 0.00 66 89.19 22 91.67 6 8.11 2 8.33 0.7181 2 2.70 0 0.00 72 97.30 24 1 0 0 .0 0 1.0000 * by F is h e r 's E x act T e st f o r 2x2 ta b le s ; by ch 1 -sq u are t e s t f o r 3x2 ta b le s . ( 0  TABLE ____ 262/268 EXPOSURE v CLINICAL LABORATORY FINDINGS EVER IN DEPARTMENT 262 OR 268? Blood R eference Ranqe U n its CBC V B C (thousand/cu.nn. ) 4.00 - 11.60 . > 11.60 D ifferen tial P o ly s(p e rc e n t) < 42.0 42.0 - 61.0 Lym phocytes(percent) 10.0 - 47.0 > 47.0 M onocytes(p e rc e n t) 0 .0 - 10.0 > 10.0 E osinophils(percent) 0.0 - 8.0 B asophils(percent) 0 .0 - 2.0 > 2.0 * by F is h e r's Exact T est. No #% Yes #* p -v a lu e 72 97.30 23 95. B3 2 2.70 1 4.17 1.0000 2 2.70 0 0.00 72 97.30 24 100.00 1.0000 72 97.30 24 100.00 2 2.70 0 / 0.00 69 93.24 20 83.33 5 6.76 4 16.67 74 1 0 0.00 24 100 .0 0 73 98.65 24 100.00 1 1.35 0 0.00 1.0000 0.2163 IfOOOO C3S721 . TABLE ____ 262/268 EXPOSURE v_ CLINICAL LABORATORY FINDINGS EVER IN DEPARTMENT 262 OR 268? Blood R eference Range U n its No % CBC Differential A bsolute V alu es(cells/cu .efn .) Weutrophlls 1650 - 6330 6330 i* L ym phocytes <1049 1049 - 3581 > 3581 72 2 1 71 2 97.30 2 .7 0 1.35 95.95 2 .7 0 M onocytes 61 - 929 > 929 73 98.65 1 1.35 E osinophils < 40 40 - 423 5 6.76 69 93.24 B asophils < 10 10 - 148 > 148 3 4.05 70 94.59 1 1.35 Yes t 24 100.00 0 0.00 0 0.00 24 100.00 0 0.00 24 1 0 0 .0 0 0 0.00 0 0.00 24^ 100.00 0 0.00 24 100.00 0 0.00 p-value 1 .0 0 0 0 0.6054 1.0000 0.3299 0.5085 * by F i s h e r 's E x ac t T e s t f o r 2x2 t a b l e s ; by c h i - s q u a r e t e s t f o r 3x2 t a b l e s C * TABLE ____ 262/268 EXPOSURE v. CLINICAL LABORATORY FINDINGS EVER IN DEPARTMENT 262 OR 268? Blood Reference Range Units T otal L1pids(gm /dL) 0.30 - 1.00 >1.00 C h o le ste ro l (mg/dL ) < 125 125 - 300 > 300 THglyceride(gg/dL) 50 - 200 > 200 T otal C holesterol(rog/dL ) < 125 125 - 300 > 300 C-HDL(mg/dL) < 30 30 - 75 > 75 C -L D K w g /d l.) < 60 60 - 185 9 185 C-VLDUimj/dl) 0.0 - 40.0 9 40 #% res 4t P-Vtlut * 72 96.00 24 100.00 3 4.00 0 0.00 1.0000 1 1.32 0 0.00 61 80.26 21 87.50 14 18.42 3 12.50 0.6675 51 67.11 18 75.00 25 32.89 6 25.00 0.6142 1 1.33 0 0.00 66 88.00 22 '9 1 .6 7 8 10.67 2 8.33 0.8003 13 17.33 5 20.83 58 77.33 18 . 75.00 4 5.33 1 4.17 0 .9 1 1 9 1 1.33 0 0.00 . 0.5010 54 72.00 20 83.33 20 26.67 4 16.67 60 80.00 17 70.83 15 20.00 7 29.17 0.4006 * by Fisher's Exact Test for 2x2 tab! ; by chi-square test for 3x2 tables. C2G723  TABLE ____ 262/268 EXPOSURE v CLINICAL LABORATORY FINDINGS EVER IN DEPARTMENT 262 OR 268? U rinalysis Act* arance C lear S pecific G ravity 1.008 - 1.036 A cetone N egative 1+ Albumin N egative G lucose N egative 2+ Blood N egative "WBC N egative 0 -2 2 -5 5 -1 0 NBC N egative 0 -2 C asts N egative B acteria None S light M oderate No #* Tes #% p-value * 74 1 0 0 .0 0 24 100.00 . 74 100.00 24 100.00 74 100.00 23 95.83 0 0.00 1 4.17 0.2449 74 100.00 24 100.00 -- 72 97.30 23 ' 95.83 2 2.70 1 . 4.17 1.0000 74 100.00 24 100.00 --------- 53 7 1 .6 2 21 8 7 .5 0 9 12.16 2 8.33 10 13.51 1 4.17 2 2.70 0 0.00 0 .1 0 # PS 0 .2 5 74 100.00 23 95.83 0 0.00 1 4.17 0.2449 74 1 0 0 .0 0 24 1 0 0 .0 0 66 8 9 .1 9 21 8 7 .5 0 7 9.46 3 12.50 1 1.35 0 0.00 0.7810 rU <O>As T  TABLE 262/268 EXPOSURE v CLINICAL LABORATORY FINDINGS EVER IN DEPARTMENT 262. OR 268? flood Reference Ranoe Units C in teli Hone Uric Acid Calclun Oxalate Yeast egat1ve PH 5 6 7 No % 72 97.30 0 0.00 2 2.70 . . 74 100.00 Yes % i 24 100.00 0 0.00 0 0.00 24 100.00 -value 1.0000 -- 53 71.62 20 63.33 16 24.32 4 - 16.67 3 4.05 0 0.00 0.4106 * by chi-square te s t. TABLE ____ AGE AND EDUCATION Afle E d u c a tio n High School High School G raduate Some C o lle g e C ollege G raduate + T* s.e.(n) 44.17 - 1.10(100) lI 15 15.00 50 50.00 27 27.00 8 8.00 6 ^ .5 7 3 Worked 1n #236 Worked in #237 Worked in #262 Worked in #268 TABLE DEPARTMENTS WORKED #% 100 100.00 56 56.00 19 19.00 10 1 0 .0 0 TABLE ____ PREVIOUS EfffLOYMENT EXPOSURES P rev io u s Employment Exposures M ech an ical Work Fanning D ust S o lv e n ts C utting O ils W e ld ln g /S o ld e rin g Fumes F ertiliz er Weed K i l l e r A sbestos Animal Feed R adiation Rubber A d d itiv es % 32 32.00 2 2.00 44 44.00 39 39.00 28 26.00 28 28.00 12 12.00 11 1 1 .0 0 3 3.00 3 3.00 2 2.00 1 1.00 TABLE ____ TOBACCO AND ALCOHOL USE Smoking S ta tu s Never ! Former P resen t (Unknown) Alcohol S ta tu s Never Former P resen t Pack Y ears* Former Smokers Pack Years P re s e n t Smokers Pack Years % Yes 22 22.45 24 24.49 52 53.06 2 7 7.00 n n.oo 82 82.00 19.12 15.77 2.42(90) 3.31(22) 29.87 3.69(46) ."\ r - .*> C TABLE ____ FAMILY HISTORY OF ILLNESS Family History Asthma H ayfever Acne Eczema H ives # % Yes 26 26.00 24 24.00 41 4 1 .0 0 6 6.00 8 8.00 TABLE ____ PERSONAL MEDICAL HISTORY P ersonal M edical H isto ry Headaches High Blood P re s su re (confirm ed) B ronchitis Pne Limoni a (confirm ed) P leurisy (confirm ed) Chest Pain (confirm ed) Kidney T rouble (confirm ed) B ladder Trouble (confirm ed) D 1 ab etes (confirm ed) Thyroid Problem s (confirm ed) Stomach U lc e r (confirm ed) C o litis (confirm ed) L iv er Problem s (confirm ed) A rthri tis Teenage Acne (HD t r e a t e d ) Skin B o lls (confirm ed) % Yes 55 55.00 23 23.00 20 23 23.00 20 20.00 11 11 1 1 .0 0 6 26 28.00 23 6 6.00 3 12 12.00 8 4 4.00 3 5 5.00 2 18 18.00 17 6 6.00 5 5 5.00 5 28 28.00 38 38.00 4 35 35.00 9 C2 6 5 9 8 Poison Ivy/O ak H ives O ther Rash (confirm ed) Skin Cancer (confirm ed) P ro state Cancer (confirm ed) TABLE % Yes 34 3 4 .0 0 14 1 4 .0 0 44 44.00 35 2 2.00 1 1 1.00 1 C2S539 TABLE _ VITAL SIGNS V ital Signs Q u etelet Index (He1ght/W e1ght x 100) S y s t o l i c BP D i a s t o l i c BP P u lse R espiration H eight W eight Tem perature X i s.e .(n ) 37.68 - 0.62(100) 122.03 - 1.63(100) 73.89 i 1.06(100) 75.SI - 1.15(100) 19.30 i 0.44(97) 69.81 - 0.27(100) 190.92 - 3.64(100) 97.84 t 0.06(95) C26600 C hloracne Comedonal C ystic P ustular Se v e r ity M ild M oderate T em poral Forehead H alar Cheeks O ccipital Neck Trunk S h o u ld e rs G enitalia TABLE ____ CHOLORACNE FINDINGS l 42 42 14 1 29 13 22 1 26 9 0 2 3 3 1 C2SC01 TABLE ____ DERMATOLOGICAL FINDINGS D erm atoloqlcal Findings A ctinic E lasto sls S everity # MTTd M oderate Severe Where Face Neck Both C hloracne & A ctinic E lasto sls D erm atologist H istory C h lo ra cn e M alar H irsutism H is to ry Acne V u lg aris Acne V u lg aris S everity M ild M oderate F o llicu litis A ctin ic K eratoses Basal C ell E pitheliom a Squamous C ell E p ith elio m a S eborrheic D erm atitis Derma top h y to s I s Hands Feet N alls O ther # % Yes 12 12.00 6 4 2 10 5 4 4.00 65 65.00 5 5.00 42 42.00 20 20.00 18 2 10 10.00 3 3.00 0-- 0 9 9.00 1 1.00 30 30.00 6 6.00 12 1 2 .0 0 C26&02 D erm atological Findings P soriasis A topic D erm atitis Poikiloderm a Face * Neck Chest O ther TABLE 0 1 1.00 1 1.00 1 1,00 0 0 1 1.00 Dermatologie Findings Derm atofibrom a Lipoma Pigm ented Nevi R osace a / RM nophyma Lichen Sim plex C hronicus A lopecia O ther Neurofibrom a Leukoderma P etech iae Ecchymoses D upuytren's C o n tractu re Ju n c tio n a l Nevi L ym phadenopathy Livedo R e tic u la ris X erosis P ilonidal Cyst O titis Externa M ild C hronic D e rm a titis X anthelasm a S eborrheic K eratoses TABLE # 1 4 7 5 3 0 0 0 1 1 1 2 2 4 0 2 1 1 8 I Tes 1.00 4 .0 0 7.00 5 .0 0 3.00 1.00 1.00 1.00 2.00 2.00 4.00 2.00 1.00 1.00 8.00 TABLE ____ CLINICAL LABORATORY FINDINGS Sodium Magnesium Potassium C hloride C alciu m Phosphorous Iron BUN C reatinine B U N /C reatin in e U ric Acid G lucose Total P ro tein Albumin X - s.e .(n ) 139.09 - 0.25(100) 2.01 - 0.02(100) 4.50 - 0.04(100) 103.57 i 0.35(99) 9.76 - 0.04(100) 2.84 - 0.04(100) 110.26 i 3.54(100) 14.99 - 0.40(100) 1.30 - 0.02(100) 11.83 t 0.37(100) 6.21 - 0.14(100) 97.37 t 2.07(100) 7.68 - 0.05(100) 4.45 - 0.03(100) C33605 Gl obul in Album1n/Globul1n Total B iliru b in D irect B iliru b in SGOT SGPT GGTP A lkaline Phosphatase LDH TABLE ____ X i i.e .(n ) 3.23 i 0.05(100) 1.41 0.03(100) 0.69 i 0.03(100) 0.19 i 0.01(100) 32.50 t 2.08(100) 43.41 3.10(100) 21.55 i 1.70(99) 31.13 i 0.80(100) 180.31 t 3.12(100) UBC RBC HGB HOT MCV MCH KCHC TABLE 3fi s.e.(n) 7.02 - 0.18(98) 5.14 - 0.44(98) 15.75 - 0.12(98) 47.79 - 0.36(98) 93.13 - 0.47(98) 30.71 - 0.18(98) 32.95 - 0.08(98) C2360 P olys (X) Lym phocytes (X) M onocytes (X) E o s in o p h ils (X) B a so p h ils (X) TABLE ____ J i s.e.(n) 59.07 > 0.80(98) 30.70 - 0.74(98) 7.21 - 0 .2 2 (9 8 ) 2.30 - 0.13(98) 0.72 i 0.05(98) C26608 Poly (Abs) Lynph (Abs) Mono (A bs) Eos (Abs) Baso (Abs) TABLE 3T - s . e . ( n ) 4211.84 1 5 1 .1 6 (9 8 ) 2097.30 - 57.17(98) 497.62 - 17.40(98) 158.30 - 9.38(98) 49.38 3.20(98) 2660 Blood R eference Ranqe U nits T o tal L1p1ds (gm/dL) C h o le ste ro l (mg/dL) T rig ly c e rid e (mg/dL) T o ta l C h o le ste ro l (mg/dL) C-HDL (mg/dL) C-LDL (m g/dL) C-VLDL (mg/dL) TABLE X - s.e .(n ) 0.67 - 0.02(99) 239.71 t 5.03(100) 162.95 - 9.19(100) 236.10 - 4.73(99) 46.71 - 1.61(99) 156.18 - 4.40(99) 33.91 2 .8 1 (9 9 ) P Specific Gravity TABLE 7 - s.t.(n) 5.29 - 0.05(98) 1.02300 - 0.00062(98) C2S611 Sodium (rrmo 1 /L ) 134.00 - 146.00 TABLE ____ BLOOD REFERENCE RANGE UNITS t 100 100.00 Kaqneslum (meq/L) 6 1 .6 0 1.60 - 2.20 > 2 .2 0 2 65 13 2.00 85.00 13.00 P o ta s s iu m (tnno 1 /L ) 3.50 - 5.50 > 5 .5 0 99 99.00 1 1.00 C h lo rid e (ntno 1 /L ) <6 9 6 .0 0 96.00 - 110.00 > 110.00 2 2.02 96 96.97 1 1.01 Calcium (mq/dL) < 8 .8 0 8.80 - 10.80 1 1.00 99 9 9 .0 0 Phosphorus (mg/dL) ^ 2.00 2.00 - 4.70 0 0.00 100 100.00 Iron (uq/dL) 4 5 .0 0 45.00 - 200.00 > 200.00 1 1.00 97 97.00 2 2.00 BUN (m q/dL) < 6 .0 0 6.00 - 25.00 > 2 5 .0 0 1 1.00 96 96 .0 0 3 3.00 C re a tin in e (mg/dL) 0.50 - 1.70 100 100.00 c 2561^ BLOOD REFERENCE RANGE W ITS TABLE BU f^Creatfnlne R atio 3.57 - 25.45 U ric A cid (mq/dL) 2.50 - 6.50 > 8 .5 0 G lucose (mq/dL) 65.00 - 130.00 > 130.00 T o tal P ro te in (mg/dL) 6.60 * 8.90 100 100.00 92 9 2 . 0 8 8.00 97 97.00 3 3.00 100 100.00 tt o m i3 BLOOD REFERENCE RANGE W I T S Albumin (gm/dL) < 3 .6 0 3.60 - 5.20 > 5 .2 0 TABLE # 1 98 1 61obul1n (gm/dL) 1.90 - 3.70 > 3 .7 0 86 14 A lbum ln/G lobulln R atio 0.46 - 2.63 100 T o ta l B ilir u b in (mq/dL) 0.10 - 1.70 > 1 .7 0 98 2 D ire c t B111rub1n (mg/dL) 0.00 - 0.30 > 0 .3 0 93 7 T ra n s a m in a s e , SGQ (IU /L ) 1.00 - 50.00 > 50.00 92 8 T ra n s a m in a s e , SGP (IU /L ) 1.00 - 70.00 > 7 0 .0 0 92 8 6-glutam yl T ra n sp e p tid a se (U/L) 1.00 - 70.00 > 7 0 .0 0 97 2 A lk alin e Phosphatase (IU /L) 10.00 - 50.00 > 5 0 .0 0 98 2 LPH-CIU/L) 90.00 - 250.00 > 2 50.00 98 2 % 1.00 98.00 1.00 66.00 14.00 100.00 98.00 2.00 93.00 7.00 92.00 8.00 92.00 8.00 97.98 2.02 98.00 2.00 9 8 .0 0 2.00 H 0 /? M BLOOD REFERENCE RANGE UNITS RBC ( m llllo n s /c u .m m .} < 4 .6 4.6 - 6.2 > 6 .2 Hemoglobin (gm/dL) < 14.0 14.0 - 18.00 > 18.00 H em atocrit (p ercen t) ^ 4 2 .0 0 42.00 - 54.00 > 5 4 .0 0 MCV ( e u . u ) 8 0 .0 0 60.00 - 100.00 > 100.00 HCH (u u a ) 26.00 26.00 - 33.00 > 3 3 .0 0 HCHC {p p rrp n t^ *= 31.00 31.00 - 36.00 TABLE % 5 5.10 92 93.88 1 1.02 3 3.06 92 93.88 3 2.04 3 3.06 93 94.90 2 2.04 1 1.02 92 93.88 5 5.10 2 2.04 88 89.80 8 8.16 2 2.04 96 97.96 C23615 BLOOD REFERENCE RANGE UNITS CSC UBC ( t h o u s a n d / c u .n n .) 4 .0 0 - 11.60 > 11.60 D ifferenti al Polys (p ercen t *42.0 4 2 .0 81.0 > 8 1 .0 lym phocytes (p ercen t} 10.0 - 47.0 > 4 7 .0 Honocytes J p e r c e n t) 0 .0 - 10.0 > 1 0 .0 E osinophil1s (p ercen t) 0.0 * 8.0 B asophils (p ercen t) 0.0 - 2.0 > 2.0 TABLE #% 95 96.94 3 3.06 2 2.04 96 97.96 0 0.00 96 97.96 2 2.04 89 90.82 9 9.18 98 100.00 97 98.98 1 1.02 C23616 BLOOD REFERENCE RANGE UNITS TABLE CSC D ifferen tial A bsolute Values (c e U s/c u .m n ,) 4 W eutropM ls 1650 *8330 >8330 96 2 L ym phocytes <1049 1049 - 3581 >3581 1 95 2 K onocytes 61 - 929 >929 97 1 E osinophils <40 40 - 423 5 93 B asophils ^10 10 - 148 >148 3 94 1 % 97.96 2 .0 4 1.02 96.94 2 .0 4 98.98 1.02 5.10 94.90 3.06 95.92 1.02 C2G61 BLOOD REFERENCE RANGE WITS, TABLE T o tal H o ld s (gm/dL) 0.30 - 1.00 > 1.00 96 96.97 3 3.03 C h o le ste ro l (mg/dL) <125 125 - 300 >300 1 1.00 82 82.00 17 17.00 T rlq ly c e H d e (mg/dL) 50 - 200 >200 69 69.00 31 3 1 .0 0 T o tal C h o le ste ro l (mg/dL) <125 125 - 300 >300 1 86 10 1.01 88.89 10.10 C-HDL (mg/dL) <30 3 0 -7 5 >75 18 18.18 76 76.77 5 5.05 C-LDL (m g/dL) <60 60 - 185 >185 1 1.01 74 74.75 24 24.24 C-VLDL (axj/dL ) 0 .0 - 40.0 > 4 0 .0 77 77.78 22 22.22 C2 6618 U rinalysis A ppearance C lear S p ecific G ravity 1.008 - 1.036 A cetone N egative 1+ Albumin N egative 61ucose N egative 2+ B lo o d N egative WBC N egative 0 -2 2 -5 5-10 RBC N egative 0 -2 C asts N egative B acterj a None S lig h t M oderate TABLE #% 98 100.00 98 * 100.00 97 98.98 1 1.02 98 100.00 95 96.94 3 3.06 98 TOO.00 74 75.51 11 1 1 .2 2 11 1 1 .2 2 2 2.04 97 98.98 1 1.02 98 100.00 87 88.78 10 10.20 1 1.02 C2G619 TABLE AGE AND EDUCATION Age E d u c a tio n High School High School G raduate Some C o lle g e . C ollege G raduate + 1T s.e .(n ) 44.17 - 1.10(100) 15 15.00 SO 5 0 .0 0 27 27.00 8 8.00 C2S62 i i i 1 Table Chloracne by Age and by Education H istory Only X + s.e .(n ) R esid u a l C h lo ra cn e X +_ s . e . ( n ) Never C hloracne X + s.e .(n ) p -v a lu e Age 4 5 .9 6 + 2 .0 6 (2 3 ) #% E d u c a tio n <High School 0 0.00 High School G ra d u a te 15 6 5 .2 2 Some C o lle g e 6 26.09 C ollege G raduate + 2 8.70 44.64 + 1.47(42) #% 9 21.43 21 50.00 10 2 3 .8 1 2 4.76 42.43 + 2.25(35) 0.4646 #% 6 17.14 i, 14 4 0 .0 0 11 3 1 .4 3 ' 4 11.43 0 .1 0 < p < 0 .2 5 C23649 Length of Time in Building 236 (Months) Length of Time Since Building 236 (Months) Table Chloracne by Length of Exposure and by Length of Time Since Cessation of Exposure History . Qnjy . J + s.e.(n) Residual X + s.e.(n) Never X + s.e.(n) p-value 38.14 + 7.74(22) 43.34 + 9.03(41) 25.09 + 7.32(34) 0.2647 135.01 + 26.52(22) 114.30 + 17.01(42) 142.49 + 22.34(34)rV 0.5779 C2 6 6 5 0 Ever in #262 or #268 #262 before #236 #262 after #236 #268 before #236 #268 after #236 Table Chloracne versus Other Exposures at the Plant Exposure Factors in Relation to Chloracne Total 24 7 13 2 10 History Only (n=Z35----- #% 7 30.43 Residual i'n-42)' #% 9 21.43 1 4.35 3 7.14 5 21.74 4 9.52 1 4.35 0 0.00 3 13.04 5 11.90 Never 7n=3S) #% 8 22.86 3 8.57 4 11.43 1 2.86 2 5.71 p-value .7ti049 .8259 .3538 .4415 .5711 C2 3 6 5 1 Table Chloracne versus Other Plant Exposures Ever in #237 Yes Ever in #262 Yes Ever in #268 Yes History Only (n=23) #% Residual (n=42) #* 13 56.52 22 52.38 Never (n=35) #% p-value 21 60.00 dj*7973 6 26.09 3 13.04 7 16.67 5 11.90 6 17.14 0.75<p<0.90 2 5.71 0.5711 026652 Table Chloracne verstis Previous Employment Exposures Previous Employment Exposures Mechanical Work Farming Oust Solvents Cutting Oils Welding/Soldering Fumes Fertilizer Weed Killer Asbestos Animal Feed Radiation Rubber Additives History Only fn=23) #% 7 30.43 0 0.00 6 26.09 8 34.78 3 13.04 7 30.43 1 4.35 2 8.70 1 4.35 0 0.00 0 0.000 0.00 Residual (n=42) ' #% 17 40.48 2 4.76 18 42.86 16 38.10 15 35.71 11 26.19 5 11.90 5 11.90 1 2.38 1 2.38 1 2.38 1 2.38 Never 7n=35) p-value #% 8 22.86 0.2519 0 0.00 0.2444 20 57.14 0.0649 15 42.86 0.8166 10 28.57 0.1498 10 28.57 0.9317 6 17.14 0.3409 4 11.43 0.9202 1 . 2.86 0.9042 2 5.71 0.4376 1 2.86 0.7292 0 0.00 0.4979 C23653 Table Chloracne versus Tobacco and Alcohol Use Smoking Status Never Former Present (Unknown) Alcohol Status Never Former Present History Only # % Yes Residual # % Yes 8 34.78 5 21.74 10 43.48 0 6 15.00 7 17.50 27 67.50 2 Never # % Yes p-value 8 22.86 12 34.29 15 42.86 0 0.1141 3 13.04 1 4.35 19 82.61 1 2.38 5 11.90 36 85.71 3 8.57 5 14.29 27 77.14 -'0.3958 : X + s.e.(n) X + s.e.(n) T + s.e.(n) Pack Years* 8.93 + 2.96(21) 27.06 + 4.42(35) 17.25 + 3.70(34) 0,0122 * p=0.0037 for comparison of history only to residual Former Smokers 8.75 + 0.75(4) Pack Years Present Smokers 16.94 + 5.85(9) Pack Years 23.29 + 6.96(7) 13.55 + 4.63(11) 0.2720 35.64 + 5.71(22) 29.17 + 6.30(15) 0.1674 Table ___ Chloracne versus Family History of Illness Family History Asthma Hayfever Acne Eczema Hives History Only # % Yes 9 39.13 5 21.74 7 30.43 3 13.04 2 8.70 Residual # % Yes 11 26.19 11 26.19 18 42.86 2 4.76 4 9.52 Never # % Yes 6 17.14 8 22.86 16 45.71 1 2.86 2 5.71 p-value 0.1747 0.9048 0.4861 0.2528 0.8203 C23655 Table Chloracne versus Personal Medical History Personal Medical History History Only _# % Yes Headaches 12 52.17 High Blood Pressure 8 34.78 (confirmed) 6 Bronchitis 8 34.78 Pneumonia (confirmed) 7 30.43 1 Pleurisy (confirmed) 3 13.04 2 Chest Pain (confirmed) 7 30.43 3 Kidney Trouble (confirmed) 2 8.70 1 Bladder Trouble (confirmed) 3 13.04 2 Diabetes (confirmed) 0 0.00 0 Thyroid Problems (confirmed) 2 8.70 2 Stomach Ulcer (confirmed) 4 17.39 .4 Coli tis (confirmed) 2 8.70 1 Liver Problems (confirmed) 2 8.70 2 Arthritis 8 34.78 Teenage Acne (MD treated) 5 21.74 0 Skin Boils (confirmed) 5 21.74 1 Residual Chloracne _# % Yes 22 52.38 5 11.90 5 9 21.43 5 11.90 5 7 16.67 5 12 28.57 12 4 9.52 2 6 14.29 3 2 4.76 1 2 4.76 0 7 16.67 7 4 9.52 4 2 4.76 2 12 28.57 19 45.24 2 18 42.86 5 Never Chloracne J _ % Yes 21 60.00 10 28.57 9 6 17.14 8 22.86 5 1 2.86 1 9 25.71 8 0 0.00 0 3 8.57 3 2 5.71 2 1 2.86 0 7 20.00 6 0 0.00 0 1 2.86 1 8 22.86 14 40.00 2 12 34.29 3 p-value 0.7618 0.0694 0.2809 0.1769 ..1462 0.9207 0.1777 0.7330 0.5247 0.6051 0.9272 0.1777 0.6051 0.6093 0.1674 0.2316 n 9 . fi.i Poison Ivy/Oak Hives Other Rash (confirmed) Skin Cancer (confirmed) Prostate Cancer (confirmed) History Only _# % Yes 9 39.13 3 13.04 12 52.17 8 1 4.35 1 0 0.00 0 Residual Chloracne _# % Yes 17 40.48 4 9.52 18 42.85 17 0 0.00 0 0 0.00 0 Never Chloracne _# % Yes 8 22.86 7 20.00 14 40.00 10 1 2.86 0 1 2.86 1 p-value 0.2241 0.4142 0.6462 0.4415 t 0.3914 Vital Signs Quetelet Index (Height/Weight xlOO) Systolic BP Diastolic BP Pulse Respiration Height Weight Temperature Table Chloracne versus Vital Signs History Only X +_ s.e. (n) Residual Chloracne X + s.e.(n) Never Chloracne X + s.e.(n) p-value 38.72 + 1.24(23) 36.62 + 0.90(42) 38.27 + 1.16(35) 0.3436 i * 123.57 + 2.85(23) 75.09 + 1.60(23) 74.35 + 2.31(23) 19.91 + 1.43(23) 70.78 + 0.56(23) 187.43 + 6.79(23) 97.76 + 0.14(22) 119.79 + 2.48(42) 71.71 + 1.53(42) 77.38 + 1.58(42) 19.54 + 0.49(39) 69.24 + 0.41(42) 194.29 + 5.56(42) 97.87 + 0.10(40) 123.71 + 3.07(35) 75.71 + 2.14(35) 74.03 + 2.21(35) 18.63 + 0.54(35) 69.86 + 0.46(35) 189.17 + 6.72(35) 97.85 + 0.11(33) O:5071 012137 0.3836 0.4900 0.0909 0.7262 0.8156 C23658 Table Chloracne versus Dermatologic Findings Dermatologic Findings History * Only (n =2T T _# % Yes Chloracne Actinic Elastosis 23 100.00 4 17.39 Severity Mild Moderate Severe 3 0 1 Where . Face Neck 2 3 Malar Hirsutism 1 4.35 History Acne Vulgaris 6 26.09 Acne Vulgaris 1 4.35 Severity hTT3 Moderate 1 0 Folliculitis 4 17.39 Actinic Keratoses 2 8.70 Basal Cell Epithelioma 0 0.00 Squamous Cell Epithelioma 0 0.00 Seborrheic Dermatitis 1 4.35 Dermatophytosis Hands Feet Nails Other 0 8 1 2 Psoriasis 0 0.00 Atopic Dermatitis 0 0.00 Residual Chloracne (n=42) _# % Yes 42 100.00 4 9.52 1 3 0 4 2 4 9.52 18 42.86 4 9.52 2 2 5 11.90 1 2.38 0 0.00 0 0.00 5 11.90 0 12 3 7 0 0.00 0 0.00 Never Chloracne (n:=35) _# % Yes 0 0.00 4 11.43 2 1 1 4 0 0 0.00 18 51.43 15 42.86 15 0 1 2.86 0 0.00 0 0.00 0 0.00 3 8.57 p-value .... 0.6415 * 0.1588 0.1695 0.1571 -- -- 0.5920 1 10 2 3 0 0.00 1 2.86 -- 0.3914 C2685S) Poikiloderma Face Neck Chest Other Dermatofibroma Lipoma Pigmented Nevi Rosacea/Rhi nophyma Lichen Simplex ' Chronicus Alopecia, Other Neurofibroma Leukoderma Petechiae Ecchymoses Dupuytren1s Contracture Junctional Nevi Lymphadenopathy Livedo Reticularis Xerosis Pilonidal Cyst Otitis Externa Mild Chronic Dermatitis Xanthelasma Seborrheic Keratoses History Only # % Yes 1 0 0 1 0 0.00 0 0.00 0 0.00 2 8.70 0 0.00 0 0.00 0 0.00 0 0.00 0 0.00 1 4.35 0 0.00 1 4.35 0 0.00 1 4.35 0 0.00 1 4.35 1 4.35 0 0.00 1 4.35 Table -- Residual Chloracne _# % Yes 0 0 0 0 0 0.00 2 4.76 2 4.76 1 2.38 2 4.76 0 0.00 0 0.00 0 0.00 0 0.00 0 0.00 1 2.38 1 2.38 1 2.38 1 2.38 0 0.00 1 2.38 0 0.00 1 2.38 3 7.14 Never Chloracne _# % Yes i 0 0 0 0 1 2.86 2 5.71 5 14.29 2 5.71 1 2.86 0 0.00 0 0.00 0 0.00 1 2.86 0 0.00 0 0.00 0 0.00 1 2.86 2 5.71 0 0.00 0 0.00 0 0.00 0 0.00 4 11.43 p-va1ue 0.3914 0.5247 0.0859 0.5206i ' :0 .5594 0.3914 0.1844 0.4979 0.4985 0.7292 0.7551 0.4985 0.1844 0.4979 0.6012 C2363 Table Chloracne versus Clinical Laboratory Findings Sodium Cage adjusted) Magnesium (age adjusted) Potassium (age adjusted) Chloride (age adjusted) Calcium (age.adjusted) Phosphorous (age adjusted) Iron (age adjusted) BUN (age adjusted) Creatinine (age adjusted) BUN/Creatinine (age adjusted) Uric Acid (age adjusted) Glucose (age adjusted) History Only X + s.e.(n) 139.70 + 0.48(23) 139.67 + 0.53 2.05 + 0.04(23) 2.04 + 0.04 4.60 + 0.07(23) 4.59 + 0.09 104.45 + 0.42(22) 104.48 + 0.74 9.73 + 0.07(23) 9,73 + 0.08 2.91 + 0.08(23) 2.92 + 0.08 118.70 + 10.50(23) 120.35 + 7.07 14.65 + 0.61(23) 14.59 T 0.84 1.32 + 0.02(23) 1.32 T 0.04 11.16 + 0.52(23) 11.11 + 0.77 6.18 + 0.27(23) 6.16 + 0.30 91.96 + 1.35(23) 91.04 + 4.18 Residual Chloracne X +_ s.e.(n) Never Chloracne X + s.e. (n) p-value 138.81 + 0.43(42) 138.80 + 0.39 2.00 + 0.03(42) 2.00 + 0.03 4.43 + 0.07(42) 4.43 + 0.06 103.67 + 0.55(42) 103.67 + 0.53 9.74 + 0.06(42) 9.74 + 0.06 2.82 + 0.05(42) 2.82 + 0.06 103.38 + 4.58(42). 103.82 + 5.22 15.10 + 0.62(42) 15.08 + 0.62 1.27 + 0.03(42) 1.27 + 0.03 12.36 + 0.65(42) 12.35 + 0.57 6.26 + 0.21(42) 6.26 + 0.22 99.10 + 4.37(42) 98.85 + 3.08 139.03 + 0.40(35) 139.06 + 0.43 2.00 + 0.04(35) 2.01 + 0.04 4.52 + 0.07(35) 4.53 + 0.07 102.89 + 0.67(35) 102.86 + 0.59 9.81 + 0.06(35) 9.81 + 0.07 2.81 + 0.06(35) 2.80 + 0.06 112.97 + 4.85(35) 111.36 + 5.74 15.09 + 0.77(35) 15.15 + 0.68 1.34 + 0.04(35) 1.34 + 0.04 11.63 + 0.63(35) 11.67 + 0.63 6.16 + 0.27(35) 6.18 + 0.25 98.86 + 2.52(35) 99.75 + 3.39 0.3999 0.4254 0.6680 0.7307 0.2790 0.2838 *0.2418 \ 0.2299 *'0.6501 : 0.6908 0.5220 0.4597 0.2131 0.1701 0.8993 0.8614 0.3007 0.2903 0.4244 0.4213 0.9484 0.9576 0.3615 0.2274 C2S6CI Table History Only X"V s.e.(n) Total Protein (age adjusted) 7.67 + 0.10(23) 7.68 + 0.11 Albumin (age adjusted) 4.50 + 0.05(23) 4.51 7 0.07 Globulin (age adjusted) Albumin/Globulin (age adjusted) 3.17 + 0.08(23) 3.16 + 0.10 1.44 + 0.04(23) 1.44 + 0.05 Total Bilirubin (age adjusted) 0.69 + 0.03(23) 0.70 + 0.06 Direct Bilirubin (age adjusted) 0.19 + 0.01(23) 0.19 + 0.02 SGOT (age adjusted) 35.78 + 7.53(23) 35.26 + 4.35 SGPT (age adjusted) 50.61 + 11.48(23) 50.01 + 6.48 GGTP (age adjusted) 21.09 + 3.01(23) 20.67 + 3.52 Alkaline Phosphatase 31.00 + 1.41(23) (age adjusted) 30.88 + 1.67 LDH (age adjusted) 176.78 + 5.98(23) 176.97 + 6.62 Residual Chloracne X + s.e.(n) 7.67 + 0.08(42) 7.68 + 0.08 4.39 + 0.07(42) 4.39 + 0.05 3.28 + 0.09(42) 3.28 + 0.08 1.38 + 0.05(42) 1.38 + 0.04 0.72 + 0.06(42) 0.72 + 0.05 0.20 + 0.02(42) 0.20 + 0.02 32.14 + 2.03(42) 32.00 +-3.21 39.88 + 2.14(42) 39.72 + 4.78 19.20 + 2.22(41) 19.07+2.63 30.29 + 1.44(42)30.25 + 1.23 181.76 + 4.73(42) 181.81 + 4.88 Never Chloracne p-value X + s.e.(n) 7.69 + 0.09(35) 7.68 + 0.09 0.9838 0.9980 4.50 + 0.04(35) 4.48 + 0.06 0.3106 0.3243 3.19 + 0.08(35) 3.20 + 0.08 0.6057 0.6111 1.44 + 0.04(35) 1.43 + 0.04 0.5599 0.5808 0.67 + 0.04(35) ' 0.8004 0.67 + 0.05 ? 0.7718 0.18 + 0.01(35)-* 0.8071 0.18+0.02 i 0.7732 30.77 + 2.40(35) 31.28 + 3.54 0.6668 0.7638 42.91 + 3.99(35) 43.50 + 5.26 0.4122 '0.4444 24.60 + 3.54(35) 25.03 + 2.86 0.3818 0.3018 32.23 + 1.16(35) 32.34 + 1.36 0.5682 0.5194 180.89 + 5.76(35) 180.71 + 5.37 0.8234 0.8374 C236G2 Table History Only X + s. e. (n) JBC [age adjusted) 6.67 + 0.43(23) 6.59 0.37 iBC 5.11 + 0.06(23) [age adjusted) 5.10 + 0.09 (age adjusted) 15.70 + 0.22(23) 15.67 + 0.25. HCT(age adjusted) 47.84 + 0.63(23) 47.75 + 0.75 MCV (age adjusted) 93.65 + 0.83(23) 93.57 + 0.98 MCH (age adjusted) 30.71 + 0.24(23) 30.69 + 0.37 MCHC (age adjusted) 32.81 + 0.15(23) 32.82 + 0.18 Residual Chloracne J + s.e. (n) 7.28 + 0.28(40) 7.27 + 0.28 5.11 + 0.05(40) 5.11 + 0.07 15.67 + 0.19(40) 15.66 + 0.19 47.52 + 0.50(40) 47.50 + 0.57 93.04 + 0.79(40) 93.02 + 0.74 30.68 + 0.31(40) 30.68 + 0.28 32.96 + 0.12(40) 32.96 + 0.13 Never Chloracne X + s.e.(n) p-value 6.94 + 0.29(35) 7.01 + 0.30 5.19 + 0.11(35) 5.20 + 0.08 15.88 + 0.22(35) 15.90 + 0.20 48.07 + 0.74 48.15 + 0.61 92.91 + 0.80(35) 92.98 + 0.79 30.74 + 0.32(35) 30.75 + 0.30 33.07 + 0.17(35) 33.06 + 0.14 0.4206 0.3382 0.6849 0.6303 0.7195 t 0.6581 ?' 0.8032 0.7421 0.8259 ", 0.8787 0.9905 0.9850 0.5166 0.5984 C206S3 Polys (*) (age adjusted) Lymphocytes (5) (age adjusted) Monocytes (%) (age adjusted) Eosinophils ( % ) (age adjusted) Basophils () (age adjusted) Table History Only X + s. e. (n) Residual Chloracne X + s.e.(n) Never Chloracne J + s.e.(n) p-value 50.36 + 1.56(23) 60.14 + 1.63 29.02 + 1.61(23) 29.24 + 1.51 7.35 + 0.43(23) 7.34 + 0.45 2.62 + 0.31(23) 2.63 + 0.27 0.65 + 0.09(23) 0.65 + 0.10 59.70 + 1.19(40) 59.67 + 1-23 30.12 + 1.11(40) 30.15 + 1.14 7.22 + 0.38(40) 7.22 + 0.34 2.21 + 0.19(40) 2.21 + 0.20 0.76 + 0.09(40) 0.76 + 0.07 57.51 + 1.43(35) 57.69 + 1.32 0.3288 0.4249 32.46 + 1.24(35) 32.28 + 1.23 0.1792 0.2526 7.12 + 0.32(35) -0.9233 7.12 + 0.37 jO.9349 2.19 + 0.21(35) -0.3901 2.18 + 0.22 -* 0.3728 0.73 + 0.06(35) 0.73 + 0.08 0.6772 0.6900 C23634 Table History Only X + s.e.(n) Residual Chi oracne X + s.,e.(n) Never Chloracne X + s.e. (n) p-value Poly (Abs) 4077.70 + 313.90(23) (age adjusted) 4010.17 + 305.65 Lymph (Abs) 1886.83 + 125.30(23) (age adjusted) 1875.95 + 116.95 Mono (Abs) (age adjusted) 488.70 + 38.99(23) 483.55 + 35.94 Eos (Abs) (age adjusted) 171.96 + 20.51(23) 171.39 + 19.65 Baso (Abs) (age adjusted) 42.04 + 6.36(23) 41.69 + 6.65 4405.15 + 229.14(40) 4395.40 + 230.95 2148.48 + 95.06(40) 2146.90 + 88.37 516.15 + 29.29(40) 515.41 + 27.16 156.83 + 13.96(40) 156.74 + 14.84 54.05 + 5.85(40) 54.00 T 5.03 4079.06 + 264.05(35) 0.5738 4134.57 + 247.80 0.5596 2177.11 + 80.36(35)- 0.1219.. 2186.05 + 94.82 j 0.0985' 482.31 + 25,07(35), 0.6746 486.55 + 29.14 0.6956 151.00 + 16.21(35)' 0.7004 151.46 + 15.93 0.7286 48.86 + 4.25(35) 0.3520 49.15 + 5.39 0.3395 G26635 Table od `erence Range 'Units History Only X + s.e.(n) Residual Chloracne X + s..e.(n) Never Chloracne X + s. e. (n) p-value :al Lipids (gm/dL) ge adjusted) Dlesterol (mg/dL) ge adjusted) iglyceride (mg/dL) ge adjusted) tal Cholesterol (mg/dL) ge adjusted) HDL (mg/dL) ge adjusted) 0.66 + 0.03(23) 0.65 + 0.04 238.39 + 8.20(23) 236.57 + 10.41 163.96 + 14.39(23) 162.10 + 19.12 232.26 + 8.00(23) 230.49 + 9.73 48.65 + 3.24(23) 49.00 + 3.68 0.67 + 0.03(41) 0.67 + 0.03 0.68 + 0.04(35) 0.8901 0.68 + 0.03 0.7835 239.74 + 9.51(42) 240.54 + 7.13(35) 0.9876 239.26 + 7.69 242.32 + 8.45 0.9105 199.55 + 16.05(42) 175.51 + 14.96(35) 0.2778 199.06 + 14.11 177.32 + 15.52 O'.2728 233.66 + 8.28(41) 241.49 + 7.70(3): 0.7012 233.38 + 7.26 242.97 + 7.89 V' 0.5450 41.32 + 2.66(41) 51.74 + 3.29(35) 0.0344* 41.37 + 2.75 51.45 + 2.99 0.0394* p=0.0117 for comparison of residual chloracne to never chloracne p=0.0148 for comparison of residual chloracne to never chloracne LDL (mg/dL) .ge adjusted) -VLDL (mg/dL) ige adjusted) 152.13 + 7.21(23) 150.53 + 9.08 32.17 + 4.40(23) 31.37 + 5.85 158.98 + 7.98(41) 155.57 + 6.88(35) 158.72 + 6.78 156.92 + 7.37 34.61 + 2.43(41) 34.23 + 6.91(35) 34.48 + 4.37 34.91 + 4.74 0.8337 0.7649 0.9432 0.8831 C2S6G6 Table History Only X + s.e.(n) Residual Chloracne X + s.e .(n) ge adjusted) ecific Gravity ,ge adjusted) 5.17 5.19 + + 1.02352 + 1.0237 + 0.08 (23) 0.11 0.0808 (23) 0.0013 5.27 5.27 + 0.08 (41) + 0.08 1.0220 + 0.0010 (41) 1.0220 + 0.0010 Never Chloracne X +_ s.e. (n) 5.38 5.37 + + 1.0239 + 1.0237 + 0.10 (34 0.09 0.0009 (34 0.00106 C266G7 Table ___ Chloracne v Clinical Laboratory Findings Blood Reference Range Units Sodium(mmol/L) 134.00 - 146.00 Magnesium(meq/L) < 1.60 1.60 - 2.20 > 2.20 Potassium(mmol/L) 3.50 - 5.50 . > 5.50 Chloride(mmo1/L) < 96.00 96.00 - 110.00 > 110.00 Calcium(mg/dL) < 8.80 8.80 - 10.80 Phosphorus(mg/dL) 2.00 - 4.70 Iron(uq/dL) < 45.00 45.00 - 200.00 > 200.00 BUN(mg/dL) < 6.00 6.00 - 25.00 > 25.00 Creatinine(mg/dL) Bun/Creatinine Ratio 3.57 - 25.45 Uric Acid(mg/dL) 2.50 - 8.50 > 8.50 History Only #% 23 100.00 1 4.35 18 78.26 4 17.39 23 100.00 0 0.00 0 0.00 22 100.00 0 0.00 0 0.00 23 100.00 23 100.00 1 4.35 20 86.96 2 8.70 0 0.00 23 100.00 0 0.00 23 100.00 23 100.00 22 95.65 1 4.35 Residual Chloracne #* 12 100.00 1 2.38 36 85.71 5 11.90 42 100.00 0 0.00 0 0.00 42 100.00 0 0.00 1 2.38 41 97.62 42 100.00 0 0.00 42 100.00 0 0.00 1 2.38 40 95.24 1 2.38 42 100.00 42 100.00 38 90.48 4 9.52 Never Chloracne % p-value 35 100.00 0 0.00 31 88.57 4 11.43 0.7378 34 97.14 1 2.86 0.3914 2 5.71 i.* 32 91.43 1 2.86 0.2263 ; 0 0.00 35 100.00 0.4979 35 100.00 0 0.00 35 100.00 0 0.00 0.0349* 0 0.00 33 94.29 2 5.71- 0.5519 35 100.00 35 100.00 32 91.43 3 8.57 G2S668 0.7540 2.I__ c T ' h l a 1C cn o I 5O? Table Chloracne v Clinical Laboratory Findings Blood Reference Range Units History Only #% Glucose(mg/dL) 65.00 - 130.00 > 130.00 23 100.00 0 0.00 Total Protein(gm/dL) 6.60 - 8.90 23 100.00 Albumin(gm/dL) < 3.60 3.60 - 5.20 > 5.20 0 0.00 23 100.00 0 0.00 Globulin(gm/dL) 1.90 - 3.70 > 3.70 21 91.30 2 8.70 Albumin/Globulin Ratio 0.46 - 2.63 23 100.00 Total Bilirubin(mg/dL) 0.10 - 1.70 > 1.70 23 100.00 0 0.00 Direct Bilirubin(mg/dL) 0.00 - 0.30 > 0.30 23 100.00 0 0.00 Transaminase, SG0(IU/L) 1.00 - 50.00 > 50.00 22 95.65 1 4.35 Transaminase, SGP(IU/L) 1.00 - 70.00 > 70.00 21 91.30 2 8.70 G-glutamyl Transpeptidase (U/L) 1.00 - '70.00 > 70.00 23 100.00 0 0.00 Alkaline Phosphatase(IU/L) 10.00 - 50.00 > 50.00 23 100.00 0 0.00 LDHCIU/L) Residual Chloracne #% 41 97.62 1 2.38 42 100.00 1 2.38 40 95.24 1 2.38 35 83.33 7 16.67 42 100.00 40 95.24 2 4.76 40 95.24 2 4.76 39 92.86 3 7.14 40 95.24 2 4.76 41 100.00 0 0.00 40 95.24 2 4.76 1 J- Never Chloracne % p-value 3 3 94.29 2 5.71 0.4376 35 100.00 0 0-.00 35 100.00 0 0.00 0.5887 30 85.71 5 14.29 0.6744> 35 100.00 35 100.00 0 0.00 0.2444 30 85.71 5 14.29 0.0859 31 88.57 4 11.43 0.6012 31 88.57 4 11.43 0.5564 33 94.29 2 5.71 0.1547 35 100.00 0 0.00 0.2444 **A 1n~T A C 2 6 6 3 9 Table Chloracne v Clinical Laboratory Findings Blood Reference Range Units RBC(millions/cu.mm.) < 4.6 4.6 - 6.2 > 6.2 Hemoglobin(gm/dL) < 14.0 14.0 - 18.00 > 18.00 Hematocrit(percent) < 42.00 42.00 - 54.00 > 54.00 MCV(cu.u) < 80.00 80.00 - 100.00 > 100.00 HCH(uug) < 26.00 26.00 - 33.00 > 33.00 MCHC(percent) < 31.00 31.00 - 36.00 History Only #% Residual Chloracne #% Never Chloracne #% p-value 0 0.00 23 100.00 0 0.00 1 2.50 39 97.50 0 0.00 4 11.43 30 85.71 1 2.86 0.1558 0 0.00 23 100.00 0 0.00 2 5.00 37 92.50 1 2.50 1 2.86 32 91.43 2 5.71 7 \' 0.5794 0 0.00 23 100.00 0 0.00 1 2.50 38 95.00 1 2.50 2 5.71 32 91.43 1 2.86 0.6840 0 0.00 22 95.65 1 4.35 1 2.50 36 90.00 3 7.50 0 0.00 34 97.14 1 2.86 0.6656 0 0.00 23 100.00 0 0.00 1 2.50 35 87.50 4 10.00 1 2.86 30 85.71 4 11.43 0.4809 0 0.00 23 100.00 1 2.50 39 97.50 1 2.86 34 97.14 0.7269 C26670 Table Chloracne v Clinical Laboratory Findings Blood Reference Range Units CBC WBC(thousand/cu.mm.) 4.00 - 11.60 > 11.60 Differential Polys(percent) < 42.00 42.00 - 81.0 > 81.0 Lymphocytes(percent) 10.0 - 47.0 > 47.0 Monocytes(percent 0.0 - 10.0 > 10.0 Eosinophils(percent) 0.0 - 8.0 Basophi1s(percent) 0.0 - 2.0 > 2.0 History Only #% Residual Chloracne #% Never Chloracne # *A p-value 22 95.65 1 4.35 39 97.50 1 2.50 34 97.14 1 2.86 0.9159 0 0.00 23 100.00 0 0.00 0 0.00 2 5.71 40 100.00 33 94.29 0 0.00 _ 0 0.00 ; * 0.1529 23 100.00 0 0.00 40 100.00 0 0.00 33 94.29 2 5.71 0.1592 20 86.96 3 13.04 35 87.50 5 12.50 34 97.14 1 2.86 0.2701 23 100.00 40 100.00 35 100.00 23 100.00 0 0.00 39 97.50 1 2.50 35 100.00 0 0.00 0.4807 C26671 Table Chloracne v Clinical Laboratory Findings Blood Reference Range Units CBC Differential Absol uteValues(cells/cu.mm) Neutrophils 1650 - 8330 > 8330 Lymphocytes < 1049 1049 - 3581 > 3581 Monocytes 61 - 929 > 929 Eosinophils < 40 40-423 Basophils < 10 10 - 148 > 148 History Only i 1- 23 100.00 0 0.00 1 4.35 22 95.65 0 0.00 23 100.00 0 0.00 1 4.35 22 95.65 2 8.70 21 91.30 0 0.00 Residual Chloracne 39 97.50 1 2.50 Never Chloracne * 34 97.14 1 2.86 . p-value 1 i* 0.7269 0 0.00 39 97.50 1 2.50 0 0.00 34 97.14 1 2.86 0.4209 39 97.50 . 35 100.00 1 2.50 0 0.00 0.4807 1 2.50 39 97.50 3 8.57 32 91.43 0.4828 0 0.00 39 97.50 1 2.50 1 2.86 34 97.14 0 0.00 0.2741 Table Chloracne versus Clinical Laboratory Findings Blood Reference Range Units Total Lipids(gn/dL) 0.30 - 1.00 > 1.00 Cholesterol(mg/dL) < 125 125-300 > 300 Tr1glyceride(mg/dL) 50 - 200 > 200 Total Cholesterol(mg/dL) < 125 125 - 300 > 300 C-HOL(mg/dL) < 30 3 0 -7 5 > 75 C-LDL(mg/dl) < 60 60 - 185 > 185 C-VL0L(mg/dl) 0.0 - 40.0 > 40.0 History Only l% Residual Chloracne #* Never Chloracne #t p-value 22 95.65 1 4.35 40 97.56 1 2.44 34 97.14 1 2.86 0.9102 0 0.00 21 91.30 2 8.70 1 2.38 33 78.57 8 19.05 0 0.00 28 80.00 7 20.00 19 82,61 4 17.39 25 59.52 17 40.48 25 71.43 10 28.57 0 0.00 21 91.30 2 8.70 1 2.44 34 82.93 6 14.63 0 0.00 33 94.29 2 5.71 0.5708 tV 0.1458 - 0.5162 3 13.04 20 86.96 0 0.00 9 21.95 31 75.61 1 2.44 6 17.14 25 71.43 4 11.43 0.2262 0 0.00 18 78.26 5 21.74 19 82.61 4 17.39 1 2.44 29 70,73 11 26.83 - 26 63.41 15 36.59 0 0.00 27 77.14 8 22.86 32 91.43 3 8.57 0.7783 0.0112 *p*0.0112 fo r com parison o f r e s td u il ch lo racn e to n ev er c h lo ra c n e . C23673 Table Chloracne versus Clinical Laboratory Findings Urinalysis Appearance Clear Specific Gravity 1.008 - 1.036 Acetone Negative 1+ Albumin Negative Glucose Negative 2+ Blood Negative WBC Negative 0 -2 2 -5 5-10 RBC Negative 0 -2 Casts Negative Bacteria None Slight Moderate History Only #% Residual Chloracne 1% Never Chloracne #% p-value 23 100.00 41 100.00 34 100.00 23 100.00 41 100.00 34 100.00 22 95.65 1 4.35 41 100.00 0 0.00 34 100.00 0 0.00 0,1926 23 100.00 41 100.00 34 100.00 23 100.00 0 0.00 40 97.56 1 2.44 32 94.12 2 5.88 '*. 0.4292 23 100.00 41 100.00 34 100.00 15 65.22 6 26.09 2 8.70 0 0.00 32 78.05 3 7.32 5 12.20 1 2.44 27 79.41 2 5.88 4 11.76 1 2.94 .25<p_<. 50 22 95.65 1 4.35 41 100.00 0 0.00 34 100.00 0 0.00 0.1926 23 100.00 41 100.00 34 100.00 t 21 91.30 2 8.70 0 0.00 38 92.68 2 4.88 1 2.44 28 82.35 6 17.65 0 0.00 0.3226 rr/i /i Ma i T ab le Chloracne versus C lin ical Laboratory Findings U rin a ly sis Crystals None Uric Acid Calcium Oxalate Yeast Negative PH 5 6 7 History n1y #X Residual Chloracne X Never Chloracne #X p-value 23 100.00 0 0.00 0 0.00 39 95.12 0 0.00 2 4.88 34 100.00 0 0.00 0 0.00 23 100.00 41 100.00 34 100.00 0.2419 5. * 19 82.61 4 17.39 0 0.00 31 75.61 9 21.95 1 2.44 23 67.65 9 26.47 2 5.88 0.6312 ) Table ___ Severity of Chloracne versus Demographic Factors Age Education < High School High School Graduate Some College College 6raduate+ Mild J + s.e.(n) 44.69 + 1.75(29) #X 7 24.14 13 44.83 7 24.14 2 6.90 Moderate J + s.e.(n) 44.54 + 2 .80(13) p-value 0.9627 V #% 2 15.38 8 61.54 3 23.08 0 0.00 0.50 < p < 0 .7 5 ^ ^D/o Severity of Chloracne versus Length of Exposure and Length of Time since Cessation of Exposure Length of Time in Building 236 (Months) Length of Time Since Building 236 (Months) Mild X + s.e.(n) 47.68 + 12.37(28) Moderate X +_ s.e. (n) 34.00 + 10.23(13) p-value 0.48?8 118.44 + 19.84(29) 105.05 + 33.70(13) 0.7208 Table Severity of Chloracne versus Other Plant Exposures Ever in #237 Yes Ever .in #262 Yes Ever in #268 Yes Mild (n=29) i% 15 51.72 4 13.79 3 10.34 Moderate (n=13) % 7 53.85 3 23.08 2 15.38 p-value i 1.0000 0.6567 0.6370 Table Severity of Chlorance versus Previous Employment Exposures Previous Employment Mechanical Work Farming Dust Solvents Cutting Oils Welding/Soldering Fumes Fertilizer Weed Killer Asbestos Animal Feed Radiation Rubber Additives Mild <n29) #% 10 34.48 2 6.90 15 51.72 11 37.93 9 31.03 8 27.59 4 13.79 2 6.90 1 3.45 1 3.45 1 3.45 1 3.45 Moderate (n=l3> #% 7 53.85 0 0.00 3 23.08 5 38.46 6 46.15 3 23.08 1 7.69 3 23.08 0 0.00 0 0.00 0 0.00 0 0.00 p-value 0.3141 1.0000 0.103t8 1.0000 0.4880 1.0000 1.0000 0.1624 1.0000 1.0000 1.0000 1.0000 f C2367U Table Severity of Chloracne versus Alcohol and Tobacco Use Smoking Status Never Former Present (Unknown) Mild (n=29) % Yes 5 17.86 5 17.86 18 64.29 1 Moderate (n=13) % Yes 1 8.33 2 16.67 9 75.00 1 p-value 0.7198 Alcohol Status Never Former Present 0 0.00 3 10.34 26 89.66 1 7.69 2 15.38 10 76.92 0.2736 Pack Years J + S.e.(n) 23.10 + 4.72(25) J + s.e.(n) 36.95 + 9.70(10) 0.1598 C2360 Table Severity of Chloracne versus Family History of Illness Family History Asthma Hayfever Acne Eczema Hives Mild (n=29) # % Yes . 9 31.03 6 20.69 12 41.38 1 3.45 4 13.79 Moderate (n=13) % Yes 2 15.38 5 38.46 6 46.15 1 7.69 0 0.00 p-value 0.4525 0.2700 1.0000 0.528S 0.2927 0236*3 Severity of Chloracne versus Personal Medical History Personal Medical History Mild (n=29) % Yes Headaches 15 51.72 High Blood Pressure 4 13.79 Bronchitis 7 24.14 Pneumonia- 4 13.79 Pleurisy 5 17.24 Chest Pain 9 31.03 Kidney Trouble 4 13.79 Bladder Trouble 5 17.24 Diabetes 1 3.45 Thyroid Problems 2 6.90 Stomach Ulcer 5 17.24 Colitis 4 13.79 Liver Problems 2 6.90 Arthritis 8 27.59 Teenage Acne 13 44.83 Skin Boils 12 41.38 Poison Ivy/Oak 14 48.28 Hives 3 10.34 Other Rash 14 48.28 Skin Cancer 0 0.00 Prostate Cancer 0 0.00 Moderate (n*13) % Yes 7 53.85 1 7.69 2 15.38 1 7.69 2 15.38 3 23.08 0 0.00 1 7.69 1 7.69 0 0.00 2 15.38 0 0.00 0 0.00 4 30.77 6 46.15 6 46.15 3 23.08 1 7.69 4 30.77 0 0.00 0 0.00 p-value 1.0000 1.0000 0.6953 1.0000 1.0000 0.722^5 0.2927 0.6468 0.5285 1.0000 1.0000 0.2927 1.0000 1.0000 1.0000 1,0000 0.1791 1.0000 0.3334 Table Severity of Chloracne versus Vital Signs Vital Signs Quetelet Index (Height/Weight x 100) Systolic BP Diastolic BP Pulse Respiration Height Weight Temperature Wild X + s.e .(n) 37.29 + 0.98(29) Moderate X + s.!. (n) 35.13 + 1.90(13) p-value 0.2706 117.93 + 3.02(29) 70.21 + 1.96(29) 78.69 + 2.03(29) 19.41 + 0.64(27) 68.62 + 0.48(29) 187.45 + 4.99(29) 97.86 + 0.12(28) 123.92 + 4.24(13) 75.08 + 2.13(13) 74.46 + 2.22(13) 19.83 + 0.72(12) 70.62 + 0.67(13) 209.54 + 13.55(13) 97.88 + 0.15(12) 0.2683 V 0.1435 0.2194 0.6938 0.0236 0.0654 0.9018 C 2 rS RD Oo u' * Table Severity of Chloracne versus Dermatologic Findings Dermatologic Findings Mild (n=29) # % Yes Actinic Elastosis 2 6.90 Severity Mild Moderate Severe 1 1 0 Where Face Neck 2 0 Malar Hirsutism 3 10.34 History Acne Vulgaris 10 34.48 Acne Vulgaris 1 3.45 Severity RTTci Moderate 1 0 Folliculitis 2 6.90 Actinic Keratoses 0 0.00 Basal Cell Epithelioma 0 0.00 Squamous Cell Epithelioma i Seborrheic Dermatitis 0 5 0.00 17.24 Dermatophytosis Hands Feet Nails Other 0 0.00 8 27.59 3 10.34 5 17.24 Psoriasis 0 0.00 Atopic Dermatitis 0 - 0.00 Moderate (n;=13) # * Yes 2 15.38 0 2 0 2 2 1 7.69 8 61.54 3 23.08 1 2 3 23.08 1 7.69 0 0.00 0 0.00 0 0.00 0 0.00 4 30.77 0 0.00 2 15.38 0 0.00 0 0.00 p-value 0.5756 1.0000 0.1766 0.0805 0.1624 0.3095 0.3020 1.0000 0.5402 1.0000 Table Severity of Chloracne versus Dermatologic Findings Dermatologic Findings Poikiloderma Face Neck Chest Other Dermatofibroma Lipoma Pigmented Nevi Rosacea/Rhinophyma Lichen Simplex Chronicus Alopecia Other Neurofibroma Leukoderma Petechiae Ecchymoses Dupuytren's Contracture Junctional Nevi Lymphadenopathy Livedo Reticularis Xerosis Pilonidal Cyst Otitis Externa Mild Chronic Dermatitis Xanthelasma Seborrheic Keratoses Mild * (n=29 ) # % Yes 0 0.00 0 0.00 0 0.00 0 0.00 0 0.00 0 0.00 2 6.90 1 3.45 1 3.45 0 0.00 0 0.00 0 0.00 0 0.00 0 0.00 1 3.45 0 0.00 1 3.45 1 3.45 0 0.00 0 0.00 0 0.00 0 0.00 2 6.90 Moderate (n= 13J 1 % Yes p-value 0 0.00 0 0.00 0 0.00 0 0.00 0 0.00 2 15.38 0 0.00 0 0.00 1 7.69 0 0.00 0 0.00 0 0.00 0 0.00 0 0.00 0 0.00 1 7.69 0 0.00 0 0.00 0 0.00 1 7.69 0 0.00 1 7.69 1 7.69 0.0906 1.0000 1.0000 0.5285 1.0000 0.3095 1.0000 1.0000 0.3095 0.3095 1.0000 C23635 Table Severity of Chloracne versus Clinical Laboratory Findings Mild I + s-e.(n) Sodium Cage adjusted) Magnesium (age adjusted) Potassium (age adjusted) Chloride (age adjusted) Calcium (age adjusted) Phosphorous (age adjusted) Iron (age adjusted) BUN (age adjusted) Creatinine (age adjusted) BUN/Creatinine (age adjusted) Uric Acid (age adjusted) Glucose (age adjusted) 138.48 + 0.50(29) 138.48 + 0.52 2.01 + 0.04(29) 2.01 + 0.04 4.42 + 0.09(29) 4.42 + 0.08 103.31 + 0.67(29) 103.31 + 0.66 9.75 + 0.08(29) 9.75 + 0.08 2.79 + 0.06(29) 2.79 + 0.06 104.93 + 5.57(29) 104.98 + 5.36 15.00 + 0.84(29) 15.00 + 0.76 1.28 + 0.04(29) 1.28 + 0.04 12.26 + 0.88(29) 12.26 + 0.79 6.13 + 0.28(29) 6.13 + 0.26 101.90 + 6.19(29) 101.86 + 5.10 Moderate X + s.e. (n) 139.54 + 0.80(13) 139.54 + 0.77 1.99 + 0.05(13) 1.99 + 0.05 4.45 + 0.06(13) 4.45 + 0.12 104.46 + 0.94(13) 104.46 + 0.99 9.71 + 0.10(13) 9.71 + 0.12 2.87 + 0.11(13) 2.87 + 0.09 99.92 + 8.27(13) 99.82 + 8.00 15.31 + 0.73(13) 15.31 + 1.13 1.25 + 0.07(13) 1.25 + 0.06 12.58 + 0.77(13) 12.58 + 1.19 6.55 + 0.28(13) 6.55 + 0.38 92.85 + 2.53(13) 92.94 + 7.62 p-value 0.2584 0.2633 0.7692 0.7745 0.8793 0.8800 0.33^8 0.3424 0.7753 0.7803 0.5099 0.5124 0.6191 0.5955 0.8209 0.8180 0.6945 0.6972 0.8225 0.8200 0.3758 0.3749 0.3445 0.3365 I ! C i? 3 6 8 6 Table Severity of Chloracne versus Clinical Laboratory Findings Mild I + s. e. (n) Moderate X + i:.e.(n) Total Protein (age adjusted) 7.76 + 0.11(29) 7.76 + 0.09 Albumin (age adjusted) 4.43 + 0.09(29) 4.43 + 0.08 Globulin (age adjusted) 3.33 + 0.12(29) 3.33 + 0.10 Albumin/Globulin (age adjusted) 1.39 + 0.07(29) 1.39 + 0.06 Total Bilirubin (age adjusted) 0.78 + 0.08(29) 0.78 + 0.07 Direct Bilirubin (age adjusted) 0.22 + 0.03(29) 0.22 + 0.03 SGOT (age adjusted) 34.83 + 2.37(29) 34.82 + 2.38 SGPT (age adjusted) 43.17 + 2.58(29) 43.16 + 2.40 GGTP (age adjusted) 18.64 + 2.57(28) 18.61 + 2.66 Alkaline Phosphatase 30.24 + 1.98(29) (age adjusted) 30.24 +* 1.78 LDH (age adjusted) 179.48 + 4.31(29) 179.50 + 5.76 7.48 + 0.08(13) 7.48 + 0.14 4.29 + 0.08(13) 4*29 + 0.12 3.18 + 0.08(13) 3.19 + 0.16 1.36 + 0.05(13) 1.36 +_ 0.09 0.58 + 0.06(13) 0.58 T 0.11 0.15 + 0.01(13) 0.15 + 0.04 26.15 + 3.46(13) 26.16 + 3.56 32.54 + 3.07(13) 32.57 + 3.58 20.38 + 4.39(13) 20.46 + 3.91 30.38 + 1.65(13) 30.39 + 2.66 186.85 + 12.15(13) 186.80 + 8.60 p-value 0.0967 0.0999 ' 0.3354 0.3403 0.4487 0.454i,,0 0.7562 0.7534 0.1493 0.1523 0.1891 0.1929 0.0472 0.0500 0.0196 0.0186 0.7194 0.6972 0.9641 0.9619 0.4790 0.4848 02o687 Table Severity of Chloracne versus Clinical Laboratory Findings Mild X +_ s .e.(n) WBC (age adjusted) RBC (age adjusted) HGB (age adjusted) HCT (age adjusted) MCV (age adjusted) MCH (age adjusted) MCHC (age adjusted) 7.43 + 0.31(27) 7.44 + 0.33 5.14 + 0.06(27) 5.14 + 0.06 15.64 + 0.25(27) 15.64 + 0.22 47.47 + 0.68(27) 47.48 + 0.60 92.44 + 1.05(27) 92.45 + 0.96 30.47 + 0.43(27) 30.47 + 0.38 32.93 + 0.15(27) 32.93 + 0.15 Moderate 1 + s.e. (n) 6.98 + 0.60(13) 6.96 + 0.48 5.05 + 0.06(13) 5.05 +_ 0.08 15.72 + 0.23(13) 15.72 + 0.32 47.62 + 0.66(13) 47.59 + 0.87 94.27 + 1.01(13) 94.25 + 1.38 31.12 + 0.35(13) 31.12 + 0.55 33.03 + 0.21(13) 33.03 + 0.21 p-value 0.4569 0.4244 0.4048 0.388% 0.8385 0.8566 0.8942 0.9158 0.2823 0.2910 0.3272 0.3367 0.6970 0.6988 C2'363y Table Severity of Chloracne versus Clinical Laboratory Findings Mild x i s.e.(n) Poly (%) Cage adjusted) Lymphocytes (50 (age adjusted) Monocytes (%) age adjusted) Eosinophils (50 (age adjusted) Basophils (50 (age adjusted) 59.45 + 1.57(27) 59.45 + 1.48 30.60 + 1.42(27) 30.59 + 1.37 6.85 + 0.42(27) 6.85 + 0.45 2.25 + 0.26(27) 2.25 + 0.23 0.86 + 0.12(27) 0.86 + 0.10 Moderate x s.e.(n) 60.22 + 1.78(13) 60.20 + 2.14 29.12 + 1.77(13) 29.14 + 1.98 7.99 + 0.7503) 7.98 + 0.66 2.12 + 0.25(13) 2.12 + 0.33 0.55 + 0.0903) 0.55 + 0.15 p-value 0.7675 0.7760 0.5412 0.5519 0.1600 0.1651 \ 0.7413 0.7566 0.0997 0.1029 Poly (Abs) (age adjusted) Lymph (Abs) (age adjusted) Mono (Abs) (age adjusted) Eos (Abs) (age adjusted) Baso (Abs) (age adjusted) 4461.56 + 252.94(27) 4466.21 7 275.49 2239.11 + 122.46(27) 2239.96 + 115.05 498.07 + 28.90(27) 498.80 + 34.22 167.00 + 19.84(27) 166.90 7 17.11 62.07 + 7.73(27) 62.13 7 6.87 4288.00 + 485.21(13) 4278.32 + 397.05 1960.23 + 136.02(13) 1958.47 7 165.81 553.69 + 68.17(13) 552.18 7 49.32 135.69 + 11.04(13) 135.91 7 24.66 37.38 + 6.27(13) 37.26 7 9.90 0.7277 0.6997 0.1725 0.1714 0.3807 0.3796 0.2994 0.3086 0.0467 0.0461 C 26* 68y Table Severity of Chloracne versus Clinical Laboratory Findings Mild X + s..e -(n) Moderate X + s,.e.(n) p-value Total Lipids (gm/dl) Cage adjusted) Cholesterol (mg/dl) (age adjusted) Triglyceride (mg/dl) (age adjusted) Total Cholesterol (mg/dl) (age adjusted) C-HDL (mg/dl) (age adjusted) C-LDL (mg/dl) (age adjusted) C-VLDL (mg/dl) (age adjusted) 0.69 + 0.03(28) 0.69 + 0.03 239.79 + 12.28(29) 239.70 + 11.16 215.10 + 20.93(29) 215.05 + 19.19 232.36 + 10.95(28) 232.52 + 9.76 38.29 + 2.73(28) 38.26- + 3.15 159.07 + 10.30(28) 159.24 + 9.32 34.79 + 2.92(28) 34.81 + 2.98 0.62 + 0.03(13) 0.62 + 0.04 239.62 + 14.61(13) 239.82 + 16.67 164.85 + 20.44(13) 164.96 + 28.66 236.46 + 11.76(13) 236.12 + 14.32 47.85 + 5.74(13) 47.89 + 4.63 158.77 + 12.50(13) 158.41 + 13.68 34.23 + ` 4.55(13) 34.18 + 4.38 0.1749 0.1600 0.9932 0.9950 0.1500 0.1544 0.829 0.8366 0.0944 0.0937 0.9862 0.9601 0.9169 0.9069 C2S690 Table Severity of Chloracne versus Clinical Laboratory Findings M ild X + s.e .(n ) pH (age adjusted) S p ecific G ravity (age adjusted) 5.29 5.28 + 7 1.0226 + 1.0226 7 0.10 0.10 (28) 0.0012 (28) 0.0012 Moderate X + s.e.(n) p-value + 1+1 5.23 5.23 1.0206 + 1.0206 7 0.12 0.14 (13) 0.0018 (13) 0.0017 0.7485 0.7593 0.3498 0.3464 C26691 Table Severity of Chloracne versus Clinical Laboratory Findings Blood Reference Range Units Sodium(mmol/L) 134.00 - 146.00 Magnesium(meg/L) < 1.60 1.60 - 2.20 > 2.20 Potass ium(nniol/L) 3.50 - 5.50 > 5.50 Chloride(nmol/L) < 96.00 96.00 - 110.00 > 110.00 Calcium(mg/dL) < 8.80 8.80 - 10.80 Phosphorus(mg/dL) 2.00 - 4.70 Iron(ug/dL) < 45.00 45.00 - 200.00 > 200.00 Mild #% Moderate #% 29 100.00 13 100.00 1 3.45 25 86.21 3 10.34 0 0.00 11 84.62 2 15.38 29 100.00 0 0.00 13 100.00 0 0.00 0 0.00 29 100.00 0 0.00 0 0.00 13 100.00 0 0.00 1 3.45 28 96.55 0 0.00 13 100.00 29 100.00 13 100.00 0 0.00 29 100.00 0 0.00 0 0.00 13 100.00 0 0.00 p-value 0.7253 . 1.0000 Table Severity of Chloracne versus Clinical Laboratory Findings Blood Reference Range Units 8UN(mg/dL) < 6.00 6.00 - 25.00 > 25.00 Creatinine(mg/dL) 0.50 - 1.70 BUN/Creatinine Ratio 3.57 - 25.45 Uric Acid(mg/dL) 2.50 - 8.50 > 8.50 Mild % Moderate % 1 3.45 27 93.10 1 3.45 0 0.00 13 100.00 0 0.00 29 100.00 13 100.00 29 100.00 13 100.00 26 89.66 3 10.34 12 92.31 1 7.69 p-value t, 0.6246 1.0000 C2369J Table Severity of Chloracne versus Clinical Laboratory Findings Blood Reference Range Units Glucose(mg/dL) 65.00 - 130.00 > 130.00 Total Protein(gm/gL) 6.60 - 8.90 Albumin(gm/dL) < 3.60 3.60 - 5.20 > 5.20 Globulin(gm/dL) 1.90 - 3.70 > 3.70 Albumin/Globulin Ratio 0.46 - 2.63 Total Bilirubin(mg/dL) 0.10 - 1.70 > 1.70 Oirect Bilirubin(mg/dL) 0.00 - 0.30 > 0.30 Transaminase, SGOCIU/L) 1.00 - 50.00 > 50.00 Mild #% Moderate #% 28 96.55 1 3.45 1 3 100.00 0 0.00 29 100.00 1 3.45 27 93.10 1 3.45 13 100.00 ' 0 0.00 13 100.00 0 0.00 23 79.31 6 20.69 12 92.31 1 7.69 29 100.00 13 100.00 27 93.10 *2 6.90 13 100.00 0 0.00 27 93.10 2 6.90 13 100.00 0 0.00 27 93.10 2 6.90 12 92.13 1 7.69 p-value 1.0000 0.62*6 : 0.4049 1.0000 1.0000 1.0000 C23694 Table Severity of Chloracne versus Clinical Laboratory Findings Blood Reference Range Units Mild #% Transaminase, SGPCIU/L) 1.00 - 70.00 > 70.00 27 93.10 2 6.90 G-glutamyl Transpeptidase(U/L) 1.00 - 70.00 > 70.00 28 100.00 0 0.00 Alkaline PhosphataseCIU/L) 10.00 - 50.00 > 50.00 27 93.10 2 6.90 LDH(IU/L) 90.00 - 250.00 > 250.00 29 100.00 0 0.00 Moderate if of A 13 100.00 0 0.00 13 100.00 0 0.00 13 100.00 0 0.00 12 92.31 1 7.69 p-value 1.0000 ____4 _ 1.0000 0.3095 c 3 6*6*95 Table Severity of Chloracne versus Clinical Laboratory Findings Blood Reference Range Units CBC WBC(thousand/cu.mm. ) 4.00 - 11.60 > 11.60 Differential Polys(percent) < 42.0 42.0 - 81.0 > 81.0 Lymphocytes(percent) 10.0 - 47.0 > 47.0 Monocytes(percent) 0.0 - 10.0 > 10.0 Eosinophils(percent) 0.0 - 8.0 Basophils(percent) 0.0 - 2.0 > 2.0 Mild % Moderate % 27 100.00 0 0.00 12 92.31 1 7.69 0 0.00 27 100.00 0 0.00 0 0.00 13 100.00 0 0.00 27 100.00 0 0.00 13 100.00 0 0.00 25 92.59 2 7.41 10 76.92 3 23.08 27 100.00 13 100.00 26 96.30 1 3.70 13 100.00 0 0.00 p-value 0.3250 t ;- -- -- - 0.3065 1.0000 Table Severity of Chloracne versus Clinical Laboratory Findings Blood Reference Range Units Mild i% CBC Differential Absolute Values(cells/cu.mm.) Neutrophils 1650 - 8330 > 8330 27 100.00 0 0.00 Lymphocytes < 1049 1049 - 3581 > 3581 0 0.00 26 96.30 1 3.70 Monocytes 61 - 929 > 929 27 100.00 0 0.00 Eosinophils < 40 40 - 423 1 3.70 26 96.30 Basophils < 10 10 - 148 > 148 0 0.00 26 96.30 1 3.70 Moderate #% 12 92.31 1 7.69 0 0.00 13 100.00 0 0.00 12 92.31 1 7.69 0 0.00 13 100.00 0 0.00 13 100.00 0 0.00 p-value 0.3250 1.0000 * 0.3250 1.0000 1.0000 c.2569 V Table Severity of Chloracne versus Clinical Laboratory Findings Blood Reference Range Units' Total Lipids(gm/dL) 0,30 - 1.00 > 1.00 Cholesterol(mg/dL) < 125 125 - 300 > 300 Tri glyceride(mg/dL) 50 - 200 > 200 Total Cholesterol(mg/dL) < 125 125 - 300 > 300 C-HDL(mg/dL) < 30 30 - 75 > 75 C-LDL(mg/dL) < 60 60 - 185 > 185 C-VLDL(mg/dL) 0.0 - 40.0 > 40 Mild 1% Moderate #% 27 96.43 1 3.57 13 100.00 0 0.00 1 3.45 23 79.31 5 17.24 0 0.00 10 76.92 3 23.08 16 55.17 13 44.83 9 69.23 4 30.77 1 3.57 22 78.57 5 17.86 0 0.00 12 92.31 1 7.69 8 28.57 20 71.43 0 0.00 1 7.69 11 84.62 1 7.69 1 3.57 20 71.43 7 25.00 0 0.00 9 69.23 4 30.77 18 64.29 10 35.71 8 61.54 5 38,46 p-value 0.6829 0.7352 1 0.5Q46 0.5238 0.1274 0.7481 1.0000 C23698 Table Severity of Chloracne versus Clinical Laboratory Findings Urine Reference Range Units Appearance Clear Specific Gravity 1.008 - 1.036 Acetone Negative 1+ Albumin Negative Glucose Negative 2+ Blood Negative WBC Negati ve 0-2 2-5 5-10 RBC Negative 0 -2 Casts Negative Bacteri a None Slight Moderate Mild #% Moderate #% 28 100.00 13 100.00 28 100.00 13 100.00 28 100.00 0 0.00 13 100.00 0 0.00 28 100.00 13 100.00 27 96.43 1 3.57 13 100.00 0 0.00 28 100.00 13 100.00 22 78.57 2 7.14 3 10.71 1 3.57 10 76.92 1 7.69 2 15.38 0 0.00 28 100.00 0 0.00 13 100.00 0 0.00 28 100.00 13 100.00 27 96.43 0 0.00 1 3.57 11 84.62 2 `15.38 0 0.00 p-value ___ i_ 1.0000 0.75<p_<0.90 0.0860 02369H e t / J Table Severity of Chloracne versus Clinical Laboratory Findings Urine Reference Range Units Crystals None Uric Acid Calcium Oxalate Yeast Negative PH 5 6 7 Mild #% Moderate 1% 26 92.86 0 0.00 2 7.14 13 100.00 0 0.00 0 0.00 28 100.00 13 100.00 21 75.00 6 21.43 1 3.57 10 76.92 3 23.08 0 0.00 p-value 1.0000 --- -- 0.7868 < C22700