Document odGXqN4Ze14MbBOE07v9Jg0o
Copies to:
Haskell
HASKELL
E, I. du Font die Nemours and Company
Laboratory for Toxicology and Industrial
LABORATORY REPORT HO. 129-66
Medicine
AR226-2826
Materials Submitted by:
aPdrouclet dCuhreR;-CDEmacahle orfattahe inabosvinegnleatdeorsiaeslo,, was administered as a rauspenaton in peanut oil by
Survivors were killed fourteen days later.
intragaatr
Results:
Suspension
___%
40 40 40 30 30 10 10
Dose mg/k)^
17,000 11,000
7,500 5,000 3,400 2,250
670
MprtalitY
0/1 0/1 0/1 0/1 0/1 0/1 0/1
Nonlothal Doses; initial weight
"Tas at 2250 mg/kg and above,
. llor, rapid respiration,
face-pawing, diarrhea for 4-5 days, wet perineal area, prostration at two hiphast levels on day of dosing
~ [ r Patholopic Chan^efl*
None attributable 'o 14 days after dosing
test
ma
Gcaapan^
,otc
2 -
Results (Cont'd.):
Suspension
___%
Dose ing/ke^
Mortality
0 40
40
17,000 11,000
0/1
Nonlethal Poses; pallor,
40 30
7,500
0/1 0/1
irregular respiration,,
2250 mg/kg
diarrhea
at
None attributable to test material, 14 days after dosin
30
5,000 3,400
0/1 0/1
and above, wet
perineal area at 7500 mg/kg
10 10
2,250
0/1
and above, initial weight losii
at 2250 ing/kg
670
0/1
6
daya
at
and above, for
17,000 nig/kg
k^
40
17,000
1/1
Lethal Doses;
40
11,000
1/1
Irregular
pallor, respiration,
salivation, wet peri
None attributable
14 days
to
test
ma
40
7,500
0/1
neal area, chewing motions at
after do'ing
30
11,000 mg/kg, prostration at
5,000
0/1
17,000 mg/kg, death day after
30 3,400 0/1 dosing
10
2,250
0/1
Monlethal Doses; pallor,
irregular respiration, diarrhea,
10
670
0/1
initial weight lose at all
levels -" for three days at
7,500 ing/kg
* Tanisdsudeusodeenxuamm.ined included lung, trachea, liver, kidney, spleen, tliymus, bone marrow, testis, brain,
Company Sanitized. Does not contain T
Summary; The three
I^^H^^kl Dosea (ALD's) being >
subject^HHMHfBmBhave
17,000
low
acute
oral
qBBIHjrespecfcively.
mg/kg, > 17,000 ing/leg, and 11,000 mg/kg toa|itv__ft^:_the_male rat, the A
f^lsBBBHHBHXHIlMB 'disclosea no abnormalitiePsaththoalot gcicoueldxabmeinaatttiroinbuotfedtwelve tissues or organs from rats thatna^receiv
to their administration to the animals.
HS;clni Date: Aueuat 15.
1966
Report by:
_ - ^X_ _^_ _^u ^^^----^^--^w^^w^^^------------ Henry S
Chief, Ortfl To
Approved by:
Company Sanitized. Does not co