Document oa9LoG0E4LJQNaxrYOEgwkoo

3M MMDICAL DEPARTTYIENT TOXICOLOGY SERVICES cc:John Butenhoff From: Marv Case Subject: Covance Study6329-222 Date: 27 July1998 On 22 July1998 when I was atCovance Madison, I reviewedthemicroscopiclivertissue sectionsof themonkeys on the4-week oralrangefmderstudyofPFOS (Covance study 6329-222).There was no evidenceof compound-relatedeffectisntheliveerven inthe highdose animals.Our toxicologyconsultanthsad askedthequestionwhetherthehigh dose monkeys had any evidenceoflivernecrosisor any othermicroscopicevidence adverselivereffects.The answer isnegative.