Document oZyZenK0OvzKkn2NgDKYjO73

r-'f { i* / Lx Ho 7 '*% ^# &aildlng Ho -3 A'frtAWMUV Aniline. M A C - 5.? p n V. 7a* Structural Formula: *nh. v C Carbon disulfide -- MAC 20 ppa -- V* Ta Thio earbanilide Structural fannulat O-CfH" t7 -^5 .Hew ground & peaked? Dusty? Can cans oymnosis Toxic or irritant -- A M A-Archives, April, 1952*. A - 22 What is it? Acetaldehyde -- M A C 200 ppm - W. 7a* Irritant to sueora membranes and a general narcotic on the central nervous system* Causes chronic intoxication similar to chronic alcoholism. Higher concentrations cause headache, stupe faction, bronchitis, pulmonary edema, diarrhea, albuminuria, fatty degenera tion of the liver and cardiao muscles, and death* -- Elkins H ->P M 0 - toluidine Structural Formulas cH3 Similar to aniline In toxicity. Injury to urinary system and more Produces less hematuria* -- cyanosis but causes A Hamilton 0u mare T -- A. M A C - 5 ppa - V. Ya.- ^ Ammonia -- M A C - 100 ppm -- W* 7a H Tenia or irritant -A M A Archives, April, 1952* Vill decoapoae an heating or grinding to acstaldebyde & amonia# Building 3. 15 Kft CH X A C - 5 B g / Mj 8 fl GK. H 0 H - K A C 10 ppa -- -- V. 7a* Chlorine - M A C 1 ppa - V* 7a* Ha 80^ -- H X 0 -- 1 /I^ _ y. T. Ha OH Triohloethylene - M A C -- 100 pja - V* 7a Struotural Ponmlai Diphenylguanidine (or DiaryIguanidine) Struotural Foxsnlai Taxio or irritant L* 708811)17 oheok here for aniline[ h C K, trioblorethyleas, bagging rather dusty. Building 8 ^A H Diethylone glycol H O -- C*" C. -- O - C*-- f;" M Toxic^ Eas eartsed 1 co per kg* fatal bladder to nan* ^M cancer. Check MH tEoassieleyiafbsiotrbiaedathsrooluvgehntthfeoraakainntetsosrcsaeuse deatl Sentomsraee -- cause aneesing* Gliding 16 fr 17 Plastic Sulfur Grinding Building Sopancx Structural Tamil* i Ad n tl n u ft/-- .-- P -- O\cHj Ssatotthit* (m (A-trtlary-batyX - a - areaoil rulfld*) Moderately toads - liver & kidney damage* 1 M A.Archives, April, .1952* Thiotox Structural Focrtailas Santocure - Similar eheaioally to thiopentex* and iaoeyclex1*, which are tcodc. Formulas H - cycle hexyl - 2 beiuiothiaxy aulienanide. S A 326 Structural Formulas v- c - ^H 1?** ***j2.~ Areakap Structural Formulas Areaket Structural Formulas Sastcnrar A Structural Formulat OH A. Miet* -1f s H H 1 H PH - C - C* H' HC* OH h S| u -c-- 1 rtcH LH H A. C-- o rt rt H S V 1 7 5 Ho defluite structure Building 21 E J>- 60 Nan-tcndc (A. K A* Archive Aprili 1952) Hsrcaptobensothlasol ?orta* t,ft4 &c(SH): O v v it i - Formaldehyde - . M A C 5 ppa - V Ta* Hez % Urea Structural Poraniat n ~~& Apparently banales. Building 21 Hlran (Parathion) Structural Pannala: Ho M A Cf but known to be very toado*. V Vapor pressore at 24 C approx* 1/3 that of mercury Feasibly oheoh here for perathion when filter press is cleaned once in 24 hours P S CL. -- torio b\ow ? Sodium ethylate Structural Fanailat 0 C^Hf'2 Cl H H Very toxio* Deoccpoaea into alcohol + Sa GB *p. - dtropbenol Structural TcraaOLiz Vary toxic. Cause* skin Irritation end cyanosis. Brwm urine* P OI3. M A C - 0.5 ppt. V..Ts. 20 cases of acnte St subacute poisoning which affected workers eaployed in the production of ? Cl^ during the period April 1951 - Hoy 25 1952 era described* `The Cone. of ? CI3 In ths workroom was 10 - 20 rsg/Hj under normal conditions and 80 - 150 &g/^3 at tinea when the plant was out of order In sente poisoning, the'disturbance* vhieh set la after 2 to 6 hours exposure ' *consist of a burning sensation la the eyes and throat, photophobia, feeling of chest .oppression, dry cough with irritation of ths conjunctival isaccm membrane of the pharynx, and slight bronchitis In subacute chronic poisoning, the symptces occur after 1 - 8 weeks work and 0oasist of slight degree of.Irritation of the pharynx, coughing, catarrh, effort and nocturnal dyspnea, with tha objective finding of' serious aathnatio bronchitis* After one to tvoyeer* employment there 'is the aj>- peorance of palaormry emphysema* In both eeixta end subacute chronic poisoning, slight rises in temperature acooepanled by noderate leuooaytoses with neutrophilia are of frequent occurence, Scentgaodoglcslly speaking* the cheat presents a normal appearance or ahou* slight signs of exaggeration of the pulmonary Barkings The soots fern clears up la 3 - 6 days The subacute form lasts 10 - 15 days and shovs a perked tendency to recur end to evolve Into chronic bronchitis of cathartic type with P CI3 Is an Irritant substance which exerts its aoticn at the level of the skin end coccus membrane, where It decomposes to E Cl and phosphorIs old, depriving the tissues of water with production of Intense heat. Workers suffering frtai poisoning should be removed from exposure and treated with frequent bathing of the eyes end with aludlne aerosols, penicillin and balsamic remedies -- Med. Lavcaro 43*293 (August - September) 1952  ' 11 Irritating, Hydrolysae to H C 1* Glycerine - non trrrio. Polyglyoerol -- nothing on it* Building 30 Sodius. -- Buff said Ethyl Alcohol -- nekea you drunk. Sodium ethylate See Building 21 above* Building 3L Toluene Sulfonic acid Structural Formula* Probably noutazlQ -- 1*.Hamilton. .Acetone -- H A G * 500 pjm - V. Va* Structural Formulas p - anino - biphenyl Structural Formulas Proa "Observations os the Effects of Diphenyl & Derivatives Upon Experimental Animala". Deichmann at al. J. I. E. k Tcac. Voi. 29, January, 1947. 1. When administered orally In olire oil to rabbits In one doee P - A - D lnduoed Increase is respiratory rate, lapbriaation, lade of appetite and loss of body weight, muscular weakness, unsteadiness, respiratory difficulties end death is coma after intervals froa 10 hours to 12 days. L D 50 a 0.69 g/ kg* 2. Order of toxicity of several oabounds is order of Increasing tcadoityj diphenyl, 0 - nitro diphenyl, p - nitro diphenyl, 0 - maino diphenyl, p - asina- diphenyl, and dlhydroocy ootaehloro diphenyl (rabbits) *" : 3. P - a -- d os aids of rabbits did not show signs of locai ixriteticai, but . isolated fatalities occurred, and all animals showed subnormal gain of body weights > - It must be concluded-that absorption took plaoe to a degree sufficient to induce systemia poisoning. 4. Repeated oral administration of p - a - d is total quantities 3 to 27 times / lethal doee induced anemia, a decrease is the number of lymphocytes, and an Increase in the number of polyaorpho - nuclear or band cella Is the peripheral circulation,; , 1 together with hematuria and hemoglobinuria. " . \ 5. p - a - d is partially conjugated is the tissues of rabbits and excreted . with hexnronio acid and organic sulfates. Output of these afforded an indirect means for estimating the extent of the absorption of p - a - d. Frcmi Brit. J. of Ind. Medicine, October, 19521 P - a - d* Animal experlmenta performed and.results show that p - a - d produces intestinal tumors Is rats. $y analogy with bearidine (which also produoea intestinal tumors is rats and bladder tumors in man, it is suggested that . p - a - d also produces bladder tumors is man. Review of history of dye workers throws suspicion on p - a - d as the prime carcinogen 'Possibly cheek mine sulfate ratio Cheek for P-A-B in grinding & drnralng out Xjone C* Since this contains up to 0*5i p a - d, take samples here This grinding A bagging operation la tasty* Ajone F -- * H - Hf diphenyl p ->pfaenyleue diamine* Similar.sherdcally to "igerite White15 'which is considered aoderately toxic* *igerite White* la N N* dibeta - naphtyl -- "p.- phenylene diamine* ? - phenylea dlaaine is toxin* Cnraehcan produced fatal .poiaoning in.cats by rubbing a fev grama into the akin* -- A* Hamilton A principal .cause of dermatitis In-the rubber industry* Ho reference on this particular derivative F -- phenatedlne*. vf t - u Structural Fctraiia* Tfeed as a drug: (antipyretic) nothing on toxicity* Should be less tcxlc than sninophenolf which lb much less tcxlc than aniline* Possibility of checking for aniline, H Cl* Santcflex k V Nothing cm it BnsidtTM ^ * ftv Flectol H -- No data* (Polymerised 2,2^4 -- triaethyl dihydro quinoline) Building D A F* 2, A, 5,-T* Structural Formula* Dermatitis produced here -- 20 Bg^qg lethal in dogs* Will oause heart end liver damage* Cheek ventilation on bagging operation, alao cono* of dust mg/Mj Sodium Triohlarqphenate Structural Formulai A tcodo material (Deng. Chemicals) W 1*^ Honoch3oroacatlo Asid H ,, o C\`C- O - O M Structural Formalax ^ Said to produce patuleta*buri followed by extentIto desquamation* It la strongly caustic -- A* HaridIton* Bttlldim? AO 'Kerosene -not considered very todo -- Jacobs* Iso p ro p a n o l -- M A C* .4CO ppm -- S tr u c tu r a l Formulai Isopropyl Zanthate ri P * V M e fr i* S tr u c tu r a l Formulai Ho r e fe r e n c e s * ri HC - H c? -- cHHu HH V.-Va* Abatol -- What la it? Malates -- Estera of malla acid & Ocenol li Aold r0 - c - t - c!-'-oH ?2 O5 la * eolid, M.P. 5 6 3 Deooepo to H, PO^ with voter. Extreme Irritant 'Can osase dermatiti** Ho cases in Industry cf brenle or systemic poisoning (Dang' Materials)* Osenol Structural Formulai Ho refarenosa M B jH ? cH- CH.-cH- cH-fct- cH -Mc H C- co ft * * HHHH H rt H H H H H H Hydrobetyl alcohol -- this is meant to be bydroebietyl alooboi MW iQiWOUUOB Ditertiary a^l phenol Structural Formula* A phenol, bat no References* Building 11 C S- M A C 20 ppm. -- V 7a* aliift# Wn<1^Tig IK Cyolohexylasdne . Structural Fomtlas ft * Highly toxic - brain A liver damage* Severe irritant to skin* Nausea and anxiety after 1 severe exposure -- Ind. Mad. Surg, July, 1950 1D 5 0 3 0*2 g/kg In ninela - severe shock, brain liver kidney daj&age. Severe irritative effect to animals, moderate sensitising effect. Severe irritative and alight sensitising effect on nan. -- A.M.A. Archives, April, 1952. (Similar chemically to cyclohexanol, vhose structural formula 1st K A O 100 ppm -- V. 7a. Non-phenolia. May paralyse the central nervous -system and is acre toxic than bensanc. Hot dangerous due to low volatility. -- Jacobs. H w about dust? Hilts 23 - 25 0. boil* at 161 0. \ Haao tertiary butyl seta oresol Structural FormulaI *So rafarenoe* Creeola genarally are sisdlar to phanol ln their physiologica! aotioa -- Irritation, diacolormtico. and erceion of tbe nkin and ssaooua meabranea, and nephritia 8 C12 ... Dark red liquid* Gorroeive liquid, deoanpoaing on aostaot vith water, foxning H Gl & S 0^ (Dang Hat}* M* P* - 78, B* F 59 C* SkellyaolYe C* These sateriala are decanea and dodeoanae* .(JGsrosene'Fraetioa) C/eHiz. c 2,2* thio bla' (4,6 dichlorcphtnol) Bo dopet Carbon tetraohlode -- tRoff Said 2,4 diohlorcphenol Toxiolty of phanol inoreaees ae chlurin* 1* added to ring* Powerful skia irritant -- * eene enridsnoe of ouanlatire aotion -- possible he&rt and kidney dasage -- Slklne* L DjO - 0,38 g& / kg -- Rata -- oral 1.73 g& / kg -- Rata roboutanaoua K P -- 45 C,B P 1329 C oH Struotural Parsulat - Kbnoohlorobensene U CI About as Toodo ae Benaene -- - Jaooba K A C -- 75 pp* -- V. Ta. CI f V Aotaser Struotural Pozsnlai OH OM Building 6 (Small Product) Botyraldehyde 'Structural Formulas rf a '+o -- C'-- H M F -- -99 C,,B. P. 75.7 C. Irritates .upper respiratory tract and xmcoua seobrasss, and can cause narcosis la animals vhidh absorb too much Ordinarily tbs degree of danger Tea. this material la mild* Creosote Oil*. B. P* 378 - 752 F. Flash Pdnt 165 F. (Closed Cup). Can cause cancer through akin contact (Carcinogens ftCaroigenoeee", Bax 67). di sethylattine K* P. -^-96 C. B.P 7*4 C 2- ethylhexaaol 3. P 183 G. Structural Fomiti 8 AAA# ' i - r r s T * Z' Can cause opaqua ooraea, keratooonus and necroeia (experimental) (Bang.Materials). Toluene M A C 200 ppa -- V Va. Structural Formimi 83 \ p - toluene sulfanchloride No references. Structural Formula* C H3 Methanol M A C 200 ppa Structural Formulai H c- or~** n Torio - destroy opila nerve* (\ Jrichlarobensene &? 23-4*8 C Structural Fognalai Similar to other chlorobensenes M A C 50 ppm Irritating to the respiratory system and eyes and oan damage the liver Effects can be serious (DangMaterial) ******* <1 ^f-Tetraohlorobenaene M P -158 C EP 246o C* Structural Formula* F/o>lding 5A rhiotzrea Structural Femlas * S - C - A/Hi. Toxic* Thiourea derivatives have been known to cause cancer in nice (Dang* Materials) Adults can tolerate 300 mg/kg for a considerable period -- Stokinger Calcita oymnamlde Structural Formila* C a C M i- Frodnoes severe lesions on mucous membranes of nose and throat, and upon skin, requiring 25 - 40 days to heal Very little alcohol after breathing cyanamlde produces rescootor depression -- flushing, sweating, rapid pulse, headache, ringjig in the ears, and dyspnea Symptoms disappear in frm an hour or two to hours* -- (A* Hamilton) 'fatal doee to nan la 40 - $0 g Chronic intcodoation la rare Host bo considered both an Irritant and syataaio.poiacn* Gastrointestinal symptoms predoainate. Can (' . .causa oonjunotivitiaf opthalaia, keratitis, injection sclerotic membrane, lachryna- tioa and ulceration of cornea Has oanstio reaotion on akin* (Dang. Material*). Use* -- Can oause burns of akin and xcnooua membranes. Sodium sulfchydrate Ka ES* w , * S -- Staff aaid ^gliding 60 ^ yp Plaatio Sulfur Sulfur Moupohlorida Sj Cl^ Apparently non-taria -- A. Hamilton. 2 - 9 ppm mildly Irritating Hydrolyses in voter to.form H d 6 S Irritation of upper respiratory tract, usually transitory -- EUdns. Brcsine -- H A C 1 ppm -- V Va. Building 66 Research laboratory Building 71 Dodeoyl Benzene Structural formulat c/*Ha* .Sodiua sulfate* fa.z, Isopropanol M A C * ADO pps - V* Va, Structural Fonaola .. rfs -- c -- fi-M Sodlua hypochlorite -- Sldu Irritant* . S O3 (liquid} H A C s 2 - 10 ppa* Irritating at 1 ppn for unexpoeed persona -- causes choking Sffecta aaa* as sulfuric acid, which is a vater solution of S O3 (Dang.Materials) Butylamina* M ? -- 50*5 C B* P* 77,8 C. Structural Fonaola* C<//? A^-. Said to be quite toodo -- Elkins*. 'c Has anmcnia Ilka odor*. Dangerous eye hazard. (Dang* Materials) Wflflaff 77A 0 - andno - biphenyl. See Building 34 shore. Structural Forgmlai Structural Fomolai n ` i1' S - .S 'r H,, V B. P* 101*8 C* Said to be rexy toxic# little known of its action In the body* Because of low. solubility Industrial poisoning la not likely to occur* Irritating to the eyes & upper respiratory tract* (Dang* Materials)* * K JL'G o f is o a s y l i s 100 p p * - Vi* Vs* di cyandlanlde (parsa). Structural Fononi** a r* h M JU^CiU^C - ^ Hydroquinone K. P. 170.5 C. Structural Formi]** B. P. 2S6.2 C oH More toxin than phenol. ID - 30 og / c u j u causes keratitis and discoloration of the conjunctiva. Ingestion of 1 g. hy an adult nay induce tinniti*y nausea, dlszinesa * sensation of suffoo*tlon9 increased rate of respiration, Ycaiting, pallor, muscular twitching, headache, dyspnea, cyanosis, delirila*, & collapse. (Dang* Materials). 0 - byphenyl higuanide. Ho reference*. Structural Formula* n h H ii .uH Tertiary Butyl Alcohol Structural Fornai* * H H,C - C - OH * ) crt3 H - butyl alcohol is irritating in concentrations orer 100 ppm. ft*TM*" n p Bensol - Huff Said. M Ac fptn Dodecyl Bensene Structural Formala* uA CivHif -H Au 78 ft 7? Thiefid* Structural Tenslas 'Tall oil -- Fiammabla liqaid Staarle Acid Structural Fcmnnlai- tiHss. C o o M