Document oMoRNQjmBEkqgywZo2v6E4em3
AR226-3186
TRADE SECRET
Study Title H-24616: Subchronic T oxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations
Volume 3 o f 5
Laboratory Project ID: DuPont-4739
DuPont-4739
Test Guidelines: U .S. EPA Health Effects Test Guidelines OPPTS 870.3100 (1998)
Author: Don A. Delker, Ph.D.
Study Completed on: October 23,2001
Performing Laboratory: E.I. du Pont de Nemours and Company Haskell Laboratory for Health and Environmental Sciences Elkton Road, P.O. B ox 50 Newark, Delaware 19714-0050
( p iiWork Request Nume Service Code Number: Sponsor Study Number:
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H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
APPENDIX F INDIVIDUAL FORELIM B AND HINDLIM B GRIP STRENGTH ASSESSM ENTS
608
Company Sanitized. Does not contain TSCA CBl
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSM ENTS FOR MALE RATS
BASELINE
FORELIMB GRIP STRENGTH (kg)
ANIMAL
MEAN OF
NUMBER TRIAL I TRIAL 2 TRIAL 3 TRIALS
HINDLIMB GRIP STRENGTH dcgl
MEAN OF TRIAL 1 TRIAL 2 TRIAL 3 TRIALS
GROUP 1:0 mg/kg/day
641083 0.71 0.75 0.75 0.73667 641084 0.55 0.68 0.74 0.65667 641085 0.86 0.93 0.77 0.85333 641101 0.94 0.75 1.01 0.90000 641105 0.62 0.84 0.61 0.69000 641123 0.86 0.84 0.86 0.85333 641154 0.46 0.68 0.74 0.62667 641159 0.70 0.85 0.86 0.80333 641165 0.46 0.54 0.40 0.46667 641215 0.66 0.63 0.37 0.55333
GROUP IE: 50 mg/kg/day
0.20 0.23 0.41 0.28000 0.22 0.27 0.44 0.31000 0.52 0.22 0.45 0.39667 0.44 0.45 0.44 0.44333 0.29 0.30 0.32 0.30333 0.31 0.28 0.34 0.31000 0.30 0.31 0.37 0.32667 0.20 0.19 0.17 0.18667 0.24 0.25 0.34 0.27667 0.37 0.41 0.33 0.37000
641055 0.45 0.89 0.55 0.63000 641056 0.51 0.72 0.47 0.56667 641073 0.66 0.79 0.62 0.69000 641081 0.82 0.84 0.60 0.75333 641144 0.56 0.57 0.67 0.60000 641146 0.52 0.91 0.58 0.67000 641178 0.64 0.71 0.40 0.58333 641198 0.63 0.77 0.56 0.65333 641218 0.61 0.76 0.78 0.71667 641224 0.61 0.57 0.79 0.65667
GROUP V: 250 mg/kg/day
641061 0.76 0.95 0.94 0.88333 641089 0.59 0.63 0.70 0.64000 641102 0.93 0.88 0.85 0.88667 641134 0.66 0.53 0.69 0.62667 641137 0.61 0.75 0.56 0.64000 641162 0.56 0.80 0.93 0.76333 641190 0.50 0.65 0.63 0.59333 641197 0.39 0.87 0.85 0.70333 641200 0.66 0.80 0.73 0.73000 641202 0.81 0.80 0.74 0.78333
0.30 0.35 0.46 0.37000 0.29 0.24 0.30 0.27667 0.34 0.24 0.26 0.28000 0.22 0.20 0.36 0.26000 0.19 0.13 0.17 0.16333 0.41 0.27 0.17 0.28333 0.27 0.20 0.27 0.24667 0.28 0.25 0.37 0.30000 0.26 0.24 0.36 0.28667 0.33 0.41 0.31 0.35000
0.33 0.40 0.37 0.36667 0.42 0.27 0.29 0.32667 0.31 0.31 0.30 0.30667 0.24 0.26 0.48 0.32667 0.34 0.27 0.22 0.27667 0.36 0.45 0.43 0.41333 0.31 0.34 0.30 0.31667 0.45 0.25 0.38 0.36000 0.31 0.44 0.53 0.42667 0.52 0.40 0.37 0.43000
I
%
609
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL FORELIMB AND H3NDLIMB GRIP STRENGTH ASSESSM ENTS FOR MALE RATS
BASELINE
FORELIMB GRIP STRENGTH (ket
HINDLIMB GRIP STRENGTH (kg')
ANIMAL
MEAN OF
NUMBER TRIAL 1 TRIAL 2 TRIAL 3 TRIALS
MEAN OF TRIAL 1 TRIAL 2 TRIAL 3 TRIALS
GROUP VII: 1000 mg/kg/day
641064 0.78 0.63 0.59 0.66667 641092 0.89 0.53 0.77 0.73000 641143 0.71 0.74 0.61 0.68667 641153 0.37 0.55 0.58 0.50000 641167 0.71 0.79 0.75 0.75000 641185 0.92 0.87 0.80 0.86333 641189 0.59 0.32 0.65 0.52000 641203 0.36 0.76 0.51 0.54333 641213 0.89 0.79 0.58 0.75333 641216 0.52 0.74 0.66 0.64000
0.22 0.22 0.20 0.21333 0.39 0.25 0.38 0.34000 0.27 0.17 0.19 0.21000 0.16 0.32 0.32 0.26667 0.33 0.33 0.42 0.36000 0.27 0.45 0.37 0.36333 0.30 0.31 0.33 0.31333 0.31 0.35 0.40 0.35333 0.35 0.38 0.43 0.38667 0.36 0.35 0.46 0.39000
610
Company Sanitized. Does not contain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL FORELIMB AND HENDLIMB GRIP STRENGTH ASSESSM ENTS FOR MALE RATS
_________________ ________________________ WEEK 12_____________________ ___ ________
FORELIMB GRIP STRENGTH Ckel
HINDLIMB GRIP STRENGTH ikg)
a n im a l
MEAN OF
NUMBER TRIAL 1 TRIAL 2 TRIAL 3 TRIALS
MEAN OF TRIAL 1 TRIAL 2 TRIAL 3 TRIALS
GROUP I: 0 mg/kg/day
641083 1.28 1.09 1.11 1.16000
641084 1.02
1.57 0.96
1.18333
641085 1.29 1.06 1.20 1.18333
641101 1.66 2.07 2.37 2.03333
641105 1.54 1.22 1.49 1.41667
641123 1.66 1.87 1.71 1.74667
641154 2.01 1.53 1.95 1.83000
641159 1.27 1.10 1.24 1.20333
641165 1.29 1.22 1.53 1.34667
641215 1.19 1.00 1.08 1.09000
GROUP III: 50 mg/kg/day
0.29 0.37 0.56 0.40667 0.50 0.47 0.66 0.54333 0.85 0.69 0.75 0.76333 0.66 0.40 0.36 0.47333 0.76 0.77 0.77 0.76667 0.56 0.62 0.67 0.61667 0.57 0.80 0.64 0.67000 0.55 0.44 0.30 0.43000 0.27 0.37 0.57 0.40333 0.69 0.62 0.70 0.67000
641055 1.30 0.98 0.84 1.04000
0.86 0.47 0.38 0.57000
641056 1.56 1.44 1.34 1.44667 0.48 0.48 0.56 0.50667
641073 0.76
1.07 0.86 0.89667
0.73 0.42 0.54 0.56333
641081 2.16 1.98 1.48 1.87333
0.25 0.27 0.47 0.33000
641144 1.69
1.18 2.06
1.64333
0.58 0.66 0.53 0.59000
641146 1.40
1.02 0.67
1.03000
0.51 0.59 0.64 0.58000
641178 1.49 1.35 1.37 1.40333
0.42 0.43 0.42 0.42333
641198 1.05 1.71 1.18 1.31333
0.52 0.45 0.39 0.45333
641218 1.78 1.95 1.47 1.73333
0.83 0.80 0.82 0.81667
641224 0.70 1.01 0.82 0.84333
0.66 0.45 0.51 0.54000
GROUP V: 250 mg/kg/day
641061 1.30 0.63 0.66 0.86333
641089 1.22 0.77 0.67 0.88667
641102 1.41 1.28 1.10 1.26333
641134 1.51
1.03 0.56
1.03333
641137 0.98 0.89 1.02 0.96333
641162 2.12
1.82 2.23 2.05667
641190 1.45 1.32 1.41 1.39333
641197 0.94 0.76 0.70 0.80000
641200 1.82 1.47 1.05 1.44667
641202 1.83 1.41 1.23 1.49000
0.65 1.00 0.87 0.84000 0.82 0.75 0.90 0.82333 0.75 0.52 0.41 0.56000 0.46 0.60 0.70 0.58667 0.83 0.59 0.66 0.69333 0.64 0.79 0.44 0.62333 0.94 0.76 1.13 0.94333 0.64 0.50 0.61 0.58333 0.58 0.38 0.40 0.45333 0.59 0.90 0.95 0.81333
611
Company San*teed. Does not contain TSCA C8(
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSM ENTS FOR MALE RATS
________ ______________________________ WEEK 12________________________________
FORELIMB GRIP STRENGTH tkel
HINDLIMB GRIP STRENGTH
a n im a l
MEAN OF
NUMBER TRIAL 1 TRIAL 2 TRIAL 3 TRIALS
MEAN OF TRIAL 1 TRIAL 2 TRIAL 3 TRIALS
GROUP VII: 1000 mg/kg/day
641064 1.28 1.00 1.64 1.30667
641092 0.82 0.92 0.84 0.86000
641143 1.56
1.17 0.81
1.18000
641153 0.87 0.47 0.26 0.53333
641167 1.47 1.54 1.86 1.62333
641185 1.54 1.75 0.90 1.39667
641189 0.80 1.05 1.72 1.19000
641203 1.52 1.17 1.03 1.24000
641213 1.14 1.26 1.98 1.46000
641216 1.62 1.45 1.78 1.61667
0.46 0.51 0.41 0.46000 0.68 0.64 0.78 0.70000 0.31 0.41 0.60 0.44000 0.41 0.61 0.40 0.47333 0.54 0.64 0.70 0.62667 0.53 0.88 0.81 0.74000 0.75 0.61 0.41 0.59000 0.52 0.57 0.64 0.57667 0.59 0.79 0.50 0.62667 0.76 0.95 0.72 0.81000
612
Company Sanitized. Does not contain TSCA CBS
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSM ENTS FOR MALE RATS
________
RECOVERY
FORELIMB GRIP STRENGTH (kg)
HINDLIMB GRIP STRENGTH (kg)
ANIMAL
MEAN OF
NUMBER TRIAL 1 TRIAL 2 TRIAL 3 TRIALS
MEAN OF TRIAL 1 TRIAL 2 TRIAL 3 TRIALS
GROUP 1:0 mg/kg/day
641083 2.42 2.40 2.19 2.33667 641084 1.37 1.45 1.17 1.33000 641085 1.00 1.16 1.24 1.13333 641101 2.12 1.53 2.37 2.00667 641105 1.88 1.17 1.60 1.55000 641123 1.57 1.38 1.30 1.41667 641154 1.19 0.95 1.05 1.06333 641159 1.58 0:91 1.55 1.34667 641165 1.40 1.83 1.85 1.69333 641215 1.26 0.66 1.05 0.99000
GROUP VII: 1000 mg/kg/day
641064 1.56 1.76 0.91 1.41000
641092 1.72 1.60 1.36 1.56000
641143 1.45 1.19 1.77 1.47000
641153 1.76
1.29 0.70
1.25000
641167 1.12
1.10 0.97
1.06333
641185 0.99 1.67 1.53 1.39667
641189 0.71 1.62 1.22 1.18333
641203 1.48 1.14 1.54 1.38667
641213 1.82 2.08 2.18 2.02667
641216 1.54 1.71 1.11 1.45333
0.99 0.72 0.73 0.81333 1.00 0.74 0.61 0.78333 0.94 0.81 0.97 0.90667 1.05 0.77 0.70 0.84000 0.96 0.99 0.99 0.98000 0.65 0.77 0.51 0.64333 1.06 0.94 0.86 0.95333 0.75 0.69 0.73 0.72333 0.70 0.47 0.38 0.51667 0.61 0.70 0.60 0.63667
0.64 0.59 0.48 0.57000 0.84 0.82 0.64 0.76667 0.38 0.70 0.84 0.64000 0.63 0.51 0.67 0.60333 0.55 0.77 0.69 0.67000 0.77 0.45 0.61 0.61000 0.72 0.90 0.69 0.77000 0.86 0.51 0.62 0.66333 0.66 0.75 0.69 0.70000 0.56 0.55 0.64 0.58333
613
Company Sanitized. Does not contain TSCA CBi
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSM ENTS FOR FEMALE RATS
__________________________
BASELINE
FORELIMB GRIP STRENGTH (kg)
HINDLIMB GRIP STRENGTH
ANIMAL
MEAN OF
NUMBER TRIAL 1 TRIAL 2 TRIAL 3 TRIALS
MEAN OF TRIAL 1 TRIAL 2 TRIAL 3 TRIALS
GROUP m 0 mg/kg/day
641253 641281 641266 641294 641325 641331 641359 641364 641383 641400
0.75 0.78 0.87 0.54 0.76 0.45 0.67 0.72 0.44 0.60
0.83 0.53 0.52 0.69 0.73 0.44 0.93 0.50 0.71 0.47
GROUP IV: 50 mg/kg/day
0.54 0.70667 0.88 0.73000 0.85 0.74667 0.56 0.59667 0.61 0.70000 0.79 0.56000 0.76 0.78667 0.61 0.61000 0.76 0.63667 0.58 0.55000
0.38 0.50 0.37 0.41667 0.40 0.31 0.29 0.33333 0.31 0.40 0.33 0.34667 0.23 0.31 0.41 0.31667 0.30 0.30 0.25 0.28333 0.28 0.26 0.19 0.24333 0.27 0.33 0.40 0.33333 0.29 0.21 0.27 0.25667 0.21 0.22 0.15 0.19333 0.36 0.27 0.37 0.33333
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
0.30 0.89 0.99 0.60 0.73 0.47 0.87 0.53 0.47 0.49
0.57 0.47 0.76 0.39 0.69 0.77 0.75 0.85 0.54 0.36
GROUP VI: 250 mg/kg/day
0.80 0.55667 0.69 0.68333 0.50 0.75000 0.51 0.50000 0.52 0.64667 0.78 0.67333 0.62 0.74667 0.78 0.72000 0.74 0.58333 0.48 0.44333
0.29 0.34 0.21 0.28000 0.26 0.27 0.35 0.29333 0.20 0.26 0.23 0.23000 0.28 0.21 0.33 0.27333 0.31 0.35 0.29 0.31667 0.32 0.45 0.43 0.40000 0.31 0.33 0.23 0.29000 0.29 0.26 0.40 0.31667 0.28 0.32 0.22 0.27333 0.21 0.34 0.48 0.34333
641244 0.59 0.47 0.48 0.51333
0.24 0.31 0.25 0.26667
641251 0.88 0.80 0.65 0.77667
0.33 0.54 0.37 0.41333
641269 0.57 0.80 0.65 0.67333
0.35 0.36 0.33 0.34667
641292 0.81 0.84 0.73 0.79333
0.31 0.52 0.46 0.43000
641302 0.66 0.58 0.75 0.66333
0.63 0.25 0.26 0.38000
641362 0.53 0.67 0.70 0.63333
0.39 0.43 0.27 0.36333
641363 0.44 0.81 0.67 0.64000
0.27 0.20 0.35 0.27333
641375 0.58 0.68 0.85 0.70333 . 0.25 0.24 0.30 0.26333
641379 1.02 1.19 1.04 1.08333
0.39 0.37 0.27 0.34333
641398 0.36 0.47 0.80 0.54333
0.51 0.38 0.42 0.43667
614
Company Sanitized. Does not contain TSC CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSM ENTS FOR FEMALE RATS
___________________________________________ BASELINE _______________________________
FORELIMB GRIP STRENGTH fkei
HINDLIMB GRIP STRENGTH fkgl
ANIMAL
MEAN OF
NUMBER TRIAL 1 TRIAL2 TRIAL 3 TRIALS
MEAN OF TRIAL 1 TRIAL 2 TRIAL 3 TRIALS
GROUP VIII: 1000 mg/kg/day
641234 0.45 0.64 0.61 0.56667 641256 0.85 1.05 1.01 0.97000 641282 0.63 0.84 0.65 0.70667 641352 0.58 0.56 0.76 0.63333 641356 0.95 0.83 0.77 0.85000 641366 0.71 0.67 0.73 0.70333 641377 0.45 0.58 0.71 0.58000 641385 0.44 0.43 0.83 0.56667 641387 0.46 0.80 0.61 0.62333 641399 0.51 0.67 0.65 0.61000
0.36 0.21 0.21 0.26000 0.32 0.39 0.50 0.40333 0.47 0.37 0.37 0.40333 0.21 0.20 0.24 0.21667 0.30 0.27 0.44 0.33667 0.21 0.32 0.30 0.27667 0.29 0.48 0.32 0.36333 0.49 0.32 0.24 0.35000 0.39 0.25 0.30 0.31333 0.31 0.33 0.40 0.34667
615
Company Sanitized. Does not contain TSCA CBi
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSM ENTS FOR FEMALE RATS
__________ _________________________________ WEEK 12________________________
FORELIMB GRIP STRENGTH ( k e )
HINDLIMB GRIP STRENGTH Heel
a n im a l
m ean of
NUMBER TRIAL 1 TRIAL 2 TRIAL 3 TRIALS
m ean of
TRIAL 1 TRIAL 2 TRIAL 3 TRIALS
GROUP H: Omg/kg/day
641253 1.24 1.36 0.81 1.13667 641266 1.00 1.33 0.64 0.99000 641281 1.59 1.29 1.17 1.35000 641294 1.17 1.42 1.72 1.43667 641325 0.89 1.20 1.19 1.09333 641331 0.53 0.73 0.54 0.60000 641359 1.66 1.14 0.81 1.20333 641364 1.15 0.85 0.94 0.98000 641383 0.58 0.88 0.87 0.77667 641400 1.22 1.49 1.16 1.29000
GROUP IV: 50 mg/kg/day
0.59 0.51 0.59 0.56333 0.59 0.53 0.58 0.56667 0.53 0.51 0.57 0.53667 0.35 0.54 0.61 0.50000 0.56 0.62 0.53 0.57000 0.58 0.38 0.47 0.47667 0.38 0.47 0.38 0.41000 0.50 0.51 0.67 0.56000 0.33 0.46 0.33 0.37333 0.73 0.49 0.42 0.54667
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
0.91 0.70 0.95 0.60 1.34 0.86 1.27 1.43 0.60 1.35
0.56 0.66 1.42 0.71 0.65 1.02 0.69 0.89 1.14 1.11
GROUP VI: 250 mg/kg/day
0.86 0.77667 0.56 0.64000 1.59 1.32000 0.74 0.68333 0.86 0.95000 0.83 0.90333 0.35 0.77000 1.18 1.16667 0.96 0.90000 1.26 1.24000
0.63 0.30 0.56 0.49667 0.66 0.71 0.42 0.59667 0.49 0.29 0.26 0.34667 0.51 0.51 0.51 0.51000 0.60 0.51 0.50 0.53667 0.23 0.70 0.50 0.47667 0.32 0.41 0.48 0.40333 0.37 0.46 0.57 0.46667 0.34 0.31 0.28 0.31000 0.42 0.26 0.70 0.46000
641244 0.99 1.14 1.32 1.15000
0.45 0.84 0.74 0.67667
641251 0.35 0.40 0.35 0.36667
0.56 0.48 0.63 0.55667
641269 0.56 0.32 0.62 0.50000
0.39 0.43 0.51 0.44333
641292 0.97 0.95 0.85 0.92333
0.53 . 0.61
0.41 0.51667
641302 1.23 0.66 0.66 0.85000
0.43 0.52 0.68 0.54333
641362 1.08 1.56 1.59 1.41000
0.58 0.54 0.45 0.52333
641363 0.99 0.85 0.71 0.85000
0.33 0.64 0.58 0.51667
641375 1.64 1.52 1.60 1.58667 , 0.66 0.73 0.58 0.65667
641379 1.52 0.76 0.52 0.93333
0.34 0.56 0.36 0.42000
641398 1.03 1.73 1.82 1.52667
0.20 0.35 0.41 0.32000
616 Ofnpany Sanitized. Does not contain TSCA CBS
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSM ENTS FOR FEMALE RATS
___________________________________________ WEEK 12__________________________________
FORELIMB GRIP STRENGTH (kg)
ANIMAL
MEAN OF
NUMBER TRIAL 1 TRIAL 2 TRIAL 3 TRIALS
HINDLIMB GRIP STRENGTH tkgl
MEAN OF TRIAL 1 TRIAL 2 TRIAL 3 TRIALS
GROUP VIII: 1000 mg/kg/day
641234 0.74 0.46 0.32 0.50667
641256 1.10 1.32 0.40 0.94000
641282 0.76 1.83 1.29 1.29333
641352 1.21 1.29 1.42 1.30667
641356 0.96 0.54 0.75 0.75000
641366 1.32 1.60 1.43 1.45000
641377 0.95 1.56 0.48 0.99667
641385 0.75 0.90 0.79 0.81333
641387 1.30 1.46 1.51 1.42333
641399 1.24
0.86
1.40 1.16667
0.43 0.51 0.34 0.42667 0.50 0.54 0.40 0.48000 0.65 0.62 0.51 0.59333 0.57 0.40 0.40 0.45667 0.56 0.49 0.61 0.55333 0.35 0.36 0.32 0.34333 0.45 0.53 0.47 0.48333 0.36 0.56 0.65 0.52333 0.27 0.26 0.38 0.30333 0.61 0.58 0.50 0.56333
617
Company Sanitized. Does not contain TSCA CBS
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSM ENTS FOR FEMALE RATS
__________
RECOVERY
FORELIMB GRIP STRENGTH (kg)
HINDLIMB GRIP STRENGTH (kg!
ANIMAL
MEAN OF
NUMBER TRIAL 1 TRIAL 2 TRIAL 3 TRIALS
MEAN OF TRIAL 1 TRIAL 2 TRIAL 3 TRIALS
GROUP II: 0 mg/kg/day
641253 1.44 1.33 1.41 1.39333
641266 0.97 1.00 0.85 0.94000
641281 0.84 0.69 0.63 0.72000
641294 1.12 1.43 1.04 1.19667
641325 1.64 1.62 1.35 1.53667
641331 0.46 0.49 0.44 0.46333
641359 1.48 1.18 1.25 1.30333
641364 0.87 0.71 0.88 0.82000
641383 0.91
0.83
0.8
0.84667
641400 1.10 0.93 0.46 0.83000
0.58 0.44 0.54 0.52000 0.48 0.37 0.43 0.42667 0.80 0.53 0.51 0.61333 0.65 0.80 1.07 0.84000 0.66 0.86 0.58 0.70000 0.52 0.52 0.65 0.56333 0.43 0.48 0.42 0.44333 0.68 0.52 0.56 0.58667 0.44 0.63 0.66 0.57667 0.46 0.49 0.59 0.51333
GROUP VIII: 1000 mg/kg/day
641234 0.62
0.47
0.4
0.49667
641256 1.42 0.72 0.89 1.01000
641282 1.39 1.11 1.22 1.24000
641352 1.19
a 0.60 0.89500
641356
a
-
-
-
641366 1.04 1.17 0.61 0.94000 641377 0.82 0.68 0.90 0.80000 641385 0.97 0.61 0.64 0.74000 641387 0.91 0.50 1.49 0.96667 641399 1.34 1.08 1.42 1.28000
0.55 0.41 0.47 0.47667 0.75 0.61 0.68 0.68000 0.45 0.77 0.68 0.63333 0.46 0.61 0.56 0.54333
--- -
0.95 0.95 0.76 0.88667 0.45 0.39 0.51 0.45000 0.56 0.67 0.60 0.61000 0.47 0.34 0.53 0.44667 0.58 0.81 0.72 0.70333
618
Company Sanitized. Does not contain TSCA CBi
H-24616: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
APPENDIX G INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSM ENTS
619 ompaiq? S a u te e d . Doe
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR MALE RATS
Group I: Omg/kg/day
Manipulation__________________ In Motor Activity
Animal Number Time Point
Approach Auditory
Pupillary
and Touch Stimulus Tail Pinch Response Defecation Urination
641083 Baseline 0 0 0 0 1 1
Week 12 0 0 0 0 0 1
Recovery
0
0
0
0
11
641084 Baseline 0 0 0 0
Week 12 0 0 0 0
Recovery
0
0
0
0
11 11 11
641085 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1 Recovery 0 0 0 1 1
641101 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1 Recovery 0 0 0 0 1 1
641105 Baseline 0 0 0 0 0 1 Week 12 0 0 -1 0 0 0 Recovery 0 0 0 0 0 1
641123 Baseline 0 0 0 0 1 1
Week 12 0 0 -1 0 1 1
Recovery
0
0
0
0
1
1
641154 Baseline 0 0 0 0 0 1
Week 12 0 0 0 0 1 1
Recovery
0
0
10
1
1
641159 Baseline 0 0 0 0 1 1
Week 12 0 0 0 0 1 1
Recovery
0
0
0
0
1
1
641165 Baseline 0 0 0 0 0 1
Week 12 0 0 0 0 0 1
Recovery
0
0
0
0
1
1
641215 Baseline 0 0 0 0 0 1
Week 12 0 0 0 0
11
Recovery
0
00
0
0
1
620
Sompanji Sanitized. Does not contain TSCA CE
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR MALE RATS
Group III: 50 mg/kg/day
Animal Number Time Point
Manipulation
In Motor Activity
Approach Auditory
Pupillary
and Touch Stimulus Tail Pinch Response Defecation Urination
641055 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1
641056 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1
641073 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 1 1
641081 Baseline 0 0 0 0 1 1 Week 12 0 -1 0 0 0 1
641144 Baseline 0 0 0 0 1 1
Week 12 0 0 0 0 0
1
641146 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 0 0
641178 Baseline 0 0 0 0 1 1
Week 12 0 0 0 0 0
1
641198 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1
641218 Baseline 0 0 0 0 Week 12 0 -1 -1 0
0 0
1 1
641224 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1
621
SanilhMft. 0esnoiconlaSnTOSA C1
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ll
DuPont-4739
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR MALE RATS
Group V: 250mg/kg/day
Manipulation__________________ In Motor Activity
Animal Number Time Point
Approach Auditory
Pupillary
and Touch Stimulus Tail Pinch Response Defecation Urination
641061 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1
641089 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1
641102 Baseline 0 0 0 0 1 1 Week 12 0 -1 -1 0 1 1
641134 Baseline 1 0 0 0 0
Week 12
0
0
0
0
0
1 1
641137 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1
641162 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 1 1
641190 Baseline 0 0 0 0 1 1 Week 12 0 0 -1 0 1 1
641197 Baseline 0 0 Week 12 0 0
00 00
0 1
1 1
641200 Baseline 0 0 0 0 1 1
Week 12 0 0 0 0 0
1
641202 Baseline 0 0 0 0 1 0
Week 12
0
0
0
0
0
1
1
622
I Does not contain TSCA CB
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR MALE RATS
Group VII: 1000 mg/kg/day______________________ ______________________________________
Manipulation _____________ In Motor Activity
Animal Number Time Point
Approach Auditory
Pupillary
and Touch Stimulus Tail Pinch Response Defecation Urination
641064 Baseline 0 0 0 0 1 1 Week 12 0 0 -1 0 1 1 Recovery 0 0 0 0 1 1
641092 Baseline 0 0 0 0 1 1
Week 12 0 0 0 0 0 1
Recovery
0
0
0
0
1
1
641143 Baseline 1 1 1 0 1 1 Week 12 0 0 0 0 1 1 Recovery 0 0 0 0 1 1
641153 Baseline 0 0 0 0 1 1
Week 12 0 0 0 0 0 1
Recovery
0
0
0
0
0
1
641167 Baseline Week 12 Recovery
0 0 0
000
1
0 -1 0
1
0 0 0a 0
1 1 1
641185 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1 Recovery 0 0 0 0 1 1
641189 Baseline 0 0 0 0 1 1
Week 12 0 0 0 0 0 0
Recovery
0
0
0
0
1
1
641203 Baseline 0 0 0 0 1 1
Week 12 0 0 0 0 0 1
Recovery
0
0
0
0
1
1
641213 Baseline 0 0 0 0 1 1
Week 12 0 0 0 0 1 1
Recovery
0
0
0
0
1
1
641216 Baseline 0 0 0 0 0 1
Week 12 0 0 0 0 1 1
Recovery
0
0
0
0
10
< ^ -0
623 Does M
T sr, ^
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR FEMALE RATS
Group II: Omg/kg/day
Manipulation _____________ In Motor Activity
Animal Number Time Point
Approach Auditory
Pupillary
and Touch Stimulus Tail Pinch Response Defecation Urination
641253 Baseline 0 0 0 0 1 1
Week 12
0
000
0
1
Recovery
0
0
0
0
0
1
641266 Baseline
0
000
0
1
Week 12
0
0
0
0
1
1
Recovery
0
000
0
1
641281 Baseline 0 0 0 0 1 1
Week 12
0
0
0
0
1
1
Recovery
0
0
0
0
0
1
641294 Baseline 0 0 0 0 0 1
Week 12
0
0
0
0
1
1
Recovery
0
0
0
0
1
1
641325 Baseline
0
000
0
1
Week 12
0
0
0
0
1
1
Recovery
0
0
0
0
1
1
641331 Baseline 0 0 -1 0 0 1
Week 12
0
0
0
0
1
1
Recovery
0
0
0
0
0
1
641359 Baseline
0
000
0
1
Week 12
0
0
0
0
1
1
Recovery
0
0
0
0
0
1
641364 Baseline 0 0 0 0 0 1
Week 12 0 0 0 0 1 1
Recovery
0
0
0
0
0
1
641383 Baseline 0 0 0 0 1 1
Week 12 0 0 -1 0
11
Recovery
0
0
0
0
1
1
641400 Baseline 0 0 0 0 0 1
Week 12
0
0
0
0
1
1
Recovery
0
0
0
0
1
1
624
Sfflltfeed Does
not con tain TSCACB
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR FEMALE RATS
Group IV: 50mg/kg/day_________________________________________________________________ Manipulation__________________ In Motor Activity
Animal Number Time Point
Approach Auditory
Pupillary
and Touch Stimulus Tail Pinch Response Defecation Urination
641260 Baseline 0 0 0 0 1 1
Week 12
0
0
0
0
1
1
641298 Baseline 1 1 1 0 0 1 Week 12 0 0 0 0 0 1
641311 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 0 1
641312 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 0 1
641313 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 0 1
641336 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 0 1
641355 Baseline 0 0 0 0 0 1 Week 12 1 1 0 0 0 1
641361 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 0
641369 Baseline 0 0 0 0 0 1 Week 12 0 0 -1 0 0 1
641396 Baseline 0 1 0 0 1 1 Week 12 0 0 0 0 0 1
625
Gompany Sanitized. Does not contain TSCA CBl
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR FEMALE RATS
Group VI: 250 mg/kg/day________________________ _______________________________________
Manipulation__________________ In Motor Activity
Animal Number Time Point
Approach Auditory
Pupillary
and Touch Stimulus Tail Pinch Response Defecation Urination
641244 Baseline 0 0 0 0 1 1
Week 12
0
0
0
0
0
1
641251 Baseline 0 0 0 0 0 Week 12 0 0 0 0 0
1 1
641269 Baseline
0
0
0
0
0
1
Week 12
0
0
-1
0
1
1
641292 Baseline
0
0
00
0
1
Week 12 0 0 0 0 0 0
641302 Baseline 0 0 0 0 1 1
Week 12
0
0
0
0
1
1
641362 Baseline 0 0 0 0 1 1
Week 12 0 0
00
0
1
641363 Baseline
0
0
00
0
1
Week 12
0
0
0
0
1
1
641375 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1
641379 Baseline 0 0 -1 0 0 1
Week 12
0
0
0
0
0
1
641398 Baseline 0 0 0 0 1 1
Week 12
0
0
0
0
0
1
626
e wpamr Sanfffeed Does no! contain TSCA CSI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR FEMALE RATS
Group VIII: 1000 mg/kg/day_____________________________________________
_____________________________ Manipulation__________________In Motor Activity_______
Animal
Approach Auditory
Pupillary
Number Time Point____and Touch Stimulus Tail Pinch Response Defecation Urination
641234 Baseline 0 0 0 0 1 1
Week 12
0
0
0
0
0
1
Recovery
0
0
0
0
0
1
641256 Baseline 0 0 0 0 1 1
Week 12 0 0 0 0 0 1
Recovery
0
0
0
0
1
1
641282 Baseline 0 0 0 0 1 1
Week 12
0
0
0
0
0
1
Recovery
0
0
0
0
1
1
641352 Baseline 0 0 0 0 1 1
Week 12 0 0 0 0 1 1
Recovery
0
0
0
0
0
1
641356 Baseline 0 0 0 0 1 1
Week 12 0 0 0 0 0 0
Recovery a
-
-
-
_
641366 Baseline 0 0 0 0 0 1
Week 12
0
0
00
0
1
Recovery
0
0
0
0
0
1
641377 Baseline 0 0 0 0 0 1
Week 12 0 0 0 0 0 1
Recovery
0
0
0
0
0
1
641385 Baseline
0
100
1
0
Week 12 0 0 0 0 1 1
Recovery
0
0
0
0
1
1
641387 Baseline 0 0 0 0
11
Week 12 0 0 0 0 1 1
Recovery
0
0
0
0
0
1
641399 Baseline 0 0 0 0 0 1
Week 12 0 0 0 0 0 1
Recovery
0
0
0
0
1
1
627
SanfHzetf. D oss not eajjfaij]
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
APPENDIX H INDIVIDUAL M OTOR ACTIVITY ASSESSM ENT: DURATION OF M OVEM ENT
628 Company Sanitized. Does
R! contain t s c a c b i
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS
ANIMAL
num ber
I
BASELINE
SUCCESSIVE 10-MINUTE INTERVALS 2345 6
TOTAL
GROUP!: Omg/kg/day
641083
332
274
264
76
6
641084
497
494
426
387
296
641085
395
304 241
127
0
641101
354
353
254
64
8
641105
458
456
303
162
4
641123
362
233
104
245
1
641154
372
277
196
195
95
641159
413
318
370
317
158
641165
345
340
165
31
0
641215
441
444
293
121
6
GROUP III: 50 mg/kg/day
2 954 90 2190 0 1067 14 1047 13 1396 2 947 96 1231 12 1588 0 881 0 1305
641055
477
433
150
0
0
641056
381
348
83
2
0
641073
401
375 255 202
57
641081
388
330
267
76
5
641144
380
362
148
7
12
641146
404
350
303
182
0
641178
433
272
140
2
2
641198
419
276
44
27 249
641218
368
328
281
271
74
641224
430
245
27
2
33
GROUP V: 250 mg/kg/day
2 1062 38 852 8 1298 0 1066 0 909 0 1239 0 849 24 1039 0 1322 0 737
641061
429
337
300
158
125
9 1358
641089
361
215
0
18 2
0 596
641102
403
310
292
85
94
0 1184
641134
359
246
129
257
188
19 1198
641137
410
336
409
336
287
306 2084
641162
388
337
20
5
3 54 807
641190
349
343
166
4Q
6
5 909
641197
335
236
214
92
22
2 901
641200
360
256
34
21
2
0 673
641202
335
251
93
1
11
9 700
629
e mpany Sanf*feed. Doe* noi confafn JSCA CB|
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS
ANIMAL NUMBER
I
BASELINE
SUCCESSIVE 10-MINUTE INTERVALS 23456
TOTAL
GROUP VII: 1000 mg/kg/day
641064
452
258
240
8
2
4 964
641092
392
289
269
29
7
7 993
641143
445
383
339
312
300
147 1926
641153
394
281
213
5
13
3 909
641167
387
365
199
6
1 2 960
641185
348
138 306
111
0
0 903
641189
368
271
121
40
16
0
816
641203
344
341
285
17
11
0 998
641213
399
273
126
54
0
0 852
641216
250
329
173
66
0
0 818
630 Ratcontain TSCA CBf
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS
ANIMAL
num ber
I
WEEK 12
SUCCESSIVE 10-MINUTE INTERVALS 2 3456
TOTAL
GROUP I: 0 mg/kg/day
641083
364
312
194
47
0
25 942
641084
455
337
347
111
1
139 1390
641085
428
192
187
179
199
150 1335
641101
369
311
264
254
18
142 1358
641105
473
438
402
288
282
200 2083
641123
331
384
251
258
224
130 1578
641154
368
320
294
228
193
168 1571
641159
442
383
315
290
213
2 1645
641165
407
339 214
184
44
4 1192
641215
514
424
409
357
350
242 2296
GROUP III: 50 mg/kg/day
641055
367
256
150
176
128
197 1274
641056
477
402
301
185 223
194 1782
641073
394
418
314
220
7
163 1516
641081
402
424
369
406
236
11 1848
641144
417
329
312
74
21
87 1240
641146
405
247
209
111
11
14 997
641178
397
295
334
260
224
131 1641
641198
414
314
23
23
5
43 822
641218
353
334
348
300
325
46 1706
641224
460
409
290
329
151
5
1644
GROUP V: 250 mg/kg/day
641061
404
343
287
641089
353
207
183
641102
465
384
273
641134
341
166 250
641137
443
363
318
641162
305
190
206
641190
400
356
256
641197
404
289
92
641200
447
329
409
641202
341
300
151
203 22 6 255 159 4 265 , 6 185 153
75 2 3 39 225 19 255 10 126 50
42 1354 5 772 5 1136 10 1061 183 1691 160 884 241 1773 114 915 0 1496 83 1078
, 631 0snPa ^ S a n ftk e d . Doe ^
A cer
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS
ANIMAL NUMBER
i
WEEK 12
SUCCESSIVE 10-MINUTE INTERVALS 22 4 56
TOTAL
GROUP VII: 1000 mg/kg/day
641064
491
309
89 220
4
10 1123
641092
488
329
44
9
14 4 888
641143
452
405
389
330
289
245 2110
641153
449
354 257
71
10
15 1156
641167
337
117
32
15 112 46 659
641185
349
291
152 363 370 264 1789
641189
386
179
1
12
0
3 581
641203
411
154
11
11
40
14 641
641213
455
311
328
131
2
2 1229
641216
353
264
212
186
219
21 1255
632 C om pany SanfiSzed. D oes not contain t s c a
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS
ANIMAL
num ber
i
RECOVERY
SUCCESSIVE 10-MINUTE INTERVALS 21 4 5 6
TOTAL
GROUP I: Omg/kg/day
641083
346
186
64
239
11
41 887
641084
360
258
223
121
41
0 1003
641085
407
219
229
125
20
118 1118
641101
297
263
152
99
146
74 1031
641105
332
289
182 196
60
8 1067
641123
383
304
213
89
51
7 1047
641154
492
323
307
105
413
359 1999
641159
489
389
378
312
283
151 2002
641165
493
386
243
148 252
76 1598
641215
328
216
162
74
9
142 931
GROUP VII: 1000 mg/kg/day
641064
401
222
123
139
31
144 1060
641092 1 403 319 211 143 246
56 1378
641143
373
297
248 205
188
120 1431
641153
360
244
166
68
168 50 1056
641167
362
304
99
110
76
14 965
641185
236
104 123 113
50
63 689
641189
349
256
146
147
179
196 1273
641203
371
232
125
129
114
75
1046
641213
324
85
260 147
18
52 886
641216
329
262
105
106
72
116 990
633
CwBPany Sanitized. Does notcontain TSCA ce?
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS
ANIMAL NUMBER
I
BASELINE
SUCCESSIVE 10-MINUTE INTERVALS 23456
TOTAL
GROUP II: Omg/kg/day
641253
438
271
237
122
2
197 1267
641266
385
355
199
144
166
81
1330
641281
369
292
310
132
135
0
1238
641294
344
294
40
3
109 3 793
641325
395
289
65
164 137
0
1050
641331
494
346
78
35 24
2 979
641359
310
239
137
255
174
167 1282
641364
282
192
128
4
12
2 620
641383
423
327
106
2
1 6 865
641400
350
235
158
45
11
5 804
GROUP IV: 50 mg/kg/day
641260
395
308
236
263
81
21 1304
641298
431
361
281
33
225 209 1540
641311
411
379
150
1
32
0 973
641312
561
519
499
485
471
403 2938
641313
306
300 219
198 208
97
1328
641336
353
262 282 229 225
40
1391
641355
353
280
260
240
215
131 1479
641361
437
375
387
137
0
0 1336
641369
255
162 145
81
0
2 645
641396
333
283
284
266
244
291
1701
GROUP VI: 250 mg/kg/day
641244
343
22
74
0
3
0 442
641251
401
313
294
187
219
104 1518
641269
343
377
267
211
384
365 1947
641292
361
237 256 292
43
11 1200
641302
482
376
331
300
275
130 1894
641362
353
271
82
4
84
4 798
641363
341
71
2
0, 6
0 420
641375
439
336
90
251
160 109 1385
641379
414
323
229
344
149
15 1474
641398
436
250
46
326
90
7 1155
634
Companysanftfzed. Does no! contain t sc a ceU
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS
ANIMAL NUMBER
I
BASELINE
SUCCESSIVE 10-MINUTE INTERVALS 23456
TOTAL
GROUP VIE: 1000 mg/kg/day
641234
372
244
258
203
371
204 1652
641256
341
217
185
120
192
169 1224
641282
308
202
163
79
0
0 752
641352
308
208
137
15
2
1 671
641356
357
197
6
90 132 104 886
641366
393
326
210
46
17
2
994
641377
468
259
2
3
9 10 751
641385
383
272
230
255
201
34 1375
641387
408
353
365
185
19
0 1330
641399
396
289
284
53
2
1 1025
635
ComPany Sanitized Does not contain TSCA CBS
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______
DuPont-4739
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS
ANIMAL
num ber
i
WEEK 12
SUCCESSIVE 10-MINUTE INTERVALS 2 34 5 6
TOTAL
GROUP II: 0 mg/kg/day
641253
362
299
143
41
2
25 872
641266
467
414
207
8
1 145 1242
641281
414
304
153
168 179
25
1243
641294
352
370
326
223
136
7
1414
641325
391
271
132
212
235
213 1454
641331
414
353
230
82
124
93 1296
641359
358
183
183
132
154
164 1174
641364
343
276
205
29
16 136 1005
641383
449
374
327
280
144
8
1582
641400
367
280
164 207
327
169 1514
GROUP IV: 50 mg/kg/day
641260
410
317
203
220
128
16 1294
641298
426'
363
393
333
171
0 1686
641311
384
307
252
154
2
3 1102
641312
425
362
123
303
173
4
1390
641313
366
303
205
79
7 208 1168
641336
368
284
244
149
233
179 1457
641355
373
333
289
242
210
67
1514
641361
486
455
272
13
17
0 1243
641369
349
211
36
153
54
0 803
641396
326
289
238
195
53
152 1253
GROUP VI: 250 mg/kg/day
641244
308
199
79
1
13
641251
298
174
118
187
78
641269
381
334
246
253
263
641292
321
317 217
51
5
641302
523
401
277 352
96
641362
328
225
158
120
40
641363
369
238
72
55 242
641375
423
304
234
227
144
641379
473
237
53
360 207
641398
373
315
126
150
55
0 600 86 941 147 1624 13 924 60 1709 11 882 34 1010 17 1349 25 1355 40 1059
636
CosssPwySa!ilffeed. Doss nof confafn TSCA Cl?
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS
ANIMAL NUMBER
I
WEEK 12
SUCCESSIVE 10-MINUTE INTERVALS 2 34 5 6
TOTAL
GROUP VET. 1000 mg/kg/day
641234
422
275
267
129
237
85 1415
641256
346
84
80 289 86
57 942
641282
279
201
119
37
60
2 698
641352
376
317
311
267
187
227 1685
641356
357
162
25
17 204 25 790
641366
405
383
174
15
5
197 1179
641377
400
264
107
20
11
2 804
641385
404
314
65
113
9
14 919
641387
415
304
8
177 172
18 1094
641399
374
352
173
55
174 228 1356
637
Sonvany Sanitized. Does not contain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS
ANIMAL NUMBER
I
RECOVERY
SUCCESSIVE 10-MINUTE INTERVALS 2 34 56
TOTAL
GROUP II: Omg/kg/day
641253
328
141
182
86
27
144 908
641266
390
308
202
217
283
99
1499
641281
363
193
114 114 112
87
983
641294
389
194 129 269
98
229 1308
641325
387
177
145 249
83
77 1118
641331
373
294
129
87
50
122 1055
641359
359
218
107
202
113
118 1117
641364
271
164
49
138 48
22 692
641383
378
167
182 120 100
85
1032
641400
270
172
117 238
130
91
1018
GROUP VIII: 1000 mg/kg/day
641234
327
233
88
118 92
103 961
641256 . 236 129 98 65 101 66 695
641282
346
127
56
115
2
14 660
641352 641356
364 a
237 -
126 -
200 -
210 -
122 1259
--
641366
429
164
167
105
134
177 1176
641377
414
126
74
37
48 244 943
641385
328
178
192 144
38
1 881
641387
411
144
169
40
94 228 1086
641399
398
210
185
127
118
71 1109
638
Does not
T8CA CBS
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
APPENDIX I INDIVIDUAL M OTOR ACTIVITY ASSESSM ENT: NUM BER OF M OVEM ENTS
639
i$0HipeMSenittsed. Does not contain TSCACBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS
ANIMAL NUMBER
I
BASELINE
SUCCESSIVE 10-MINUTE INTERVALS 23456
TOTAL
GROUP I: 0 mg/kg/day
641083
133
125 155
36
6
641084
76
67
66
73
65
641085
122
116 125
95
0
641101
123
128 145
47
8
641105
114
126 129
92
4
641123
128
122
82
111
3
641154
118
123
127
129
76
641159
133
136
124
138
98
641165
147
125 116
38
4
641215
100
102 122
87
6
5 460 33 380 1 459 12 463 11 476 6 452 81 654 14 643 3 433 2 419
GROUP III: 50 mg/kg/day
641055
80
87
75
0
0
1 243
641056
143
140
71
7 '3
25 389
641073
125
116 132
96
36
8 513
641081
111
137 109
55
8
3 423
641144
130
131
100
10
25
1 397
641146
138
131
164
117
2
0 552
641178
109
142
90
5
2
3 351
641198
123
129
55
14 126 33 480
641218
144
148 136 165
86
2
681
641224
112
91
21
5
12
2 243
GROUP V: 250 mg/kg/day
641061
122
140 117
117
77
9
582
641089
141
127
0
12
3
1 284
641102
137
139
127
81
82
3
569
641134
125
138
97
135 94
26 615
641137
103
128
158
162
160
155
866
641162
127
132
15
3
7 34 318
641190
118
125 100
28,
5
13 389
641197
133
137 156
108
30
6
570
641200
135
129
31
17
2
2 316
641202
136
160
90
8
10 15 419
640
fCoupeny Sanitized. Does <*H|c'wtain TSCA CB
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS
ANIMAL NUMBER
12
BASELINE
SUCCESSIVE 10-MINUTE INTERVALS
34
56
TOTAL
GROUP VII: 1000 mg/kg/day
641064
114
107
81
17
5
6 330
641092
126
123
128
43
6
10 436
641143
119
142
136
132
173
132
834
641153
121
137
130
8
18
8 422
641167
144
139
125
11
3
2 424
641185
143
95
138
57
0
3 436
641189
155
136
93
27
20
0 431
641203
146
134
125
20
21
2 448
641213
137
160 117
52
0
0 466
641216
128
148
130
50
0
0 456
641
ompenjf SanUzscL Does not contain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS
ANIMAL NUMBER
I
WEEK 12
SUCCESSIVE 10-MINUTE INTERVALS 2 345
6
TOTAL
GROUP I: Omg/kg/day
641083
162
145
122
40
3
28 500
641084
121
135
138
62
4
90 550
641085
125
88
91
120 89
97 610
641101
139
150
136
148
17
59 649
641105
111
115
125
129
131
100 711
641123
121
123
118 113 128
95
698
641154
140
130
117
129
114
104 734
641159
143
151
140
126
115
2
677
641165
138
133
149
112
26
7 565
641215
96
109 110 121 154
97
687
GROUP III: 50 mg/kg/day
641055
132
129
80
99
73
106 619
641056
113
134
134
120
99
114 714
641073
128
103
144
98
8
88 569
641081
120
105
113
122
109
8
577
641144
118
139
162
34
15
66 534
641146
122
139
100
94
10
20 485
641178
137
129
152 126 116
94
754
641198
130
140
13
17
7
31 338
641218
135
138
153
130
161
53
770
641224
109
138
136
99
58
5 545
GROUP V: 250 mg/kg/day
641061
139
147
149 142
81
54 712
641089
151
139
82
18
4
7 401
641102
121
152
144
6
7
13 443
641134
147
87
121 119 35
9 518
641137
129
148
144
87
116 108 732
641162
133
101
100
8
26
85 453
641190
106
130
111
124 161
90
722
641197
152
167
62
6
17 110 514
641200
108
134
150
118
97
0 607
641202
140
150
114 111
48
71 634
642
Sanpoqf Sanitized. Does not contain TSCA r e t
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS
ANIMAL NUMBER
1
WEEK 12
SUCCESSIVE 10-MINUTE INTERVALS 234 5 6
TOTAL
GROUP VII: 1000 mg/kg/day
641064
96
106 50
82
8
13 355
641092
117
116
12
12
14
10 281
641143
115
116
137
150
138
122
778
641153
122
127
136
44
9
12 450
641167
160
97
31
16
98
43 445
641185
125
132
61
144 142 125 729
641189
162
141
8
23
2
8 344
641203
151
65
15
10
33
17 291
641213
118
141
160
76
2
6 503
641216
136
138
98
114 136
20
642
643
wnpasif Sanftbeed. Does notcontain TSC CBf
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
1 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS
ANIMAL
num ber
i
RECOVERY
SUCCESSIVE 10-MINUTE INTERVALS 23456
TOTAL
GROUPE Omg/kg/day
641083
141
122
39
114
16
39
471
641084
130
142 147
57
33
2 511
641085
120
121
120
76
25
55
517
641101
111
132
89
75
78
65 550
641105
148
150
86
125
36
12 557
641123
144
138 121
59
28
9 499
641154
62
62 44
16
53
57 294
641159
119
135 130 155 145
90
774
641165
113
115
96
61
115 45 545
641215
129
147 121
59
12 119 587
GROUP VII: 1000 mg/kg/day
641064
133
86
47
78
24
79 447
641092
117
115 122
80
96
30 560
641143
125
124 113 116 114
94
686
641153
157
167
125
70
125
58
702
641167
127
149
52
80
49
20 477
641185
129
87 110 40
50
74 490
641189
144
149 132
89
89 148 751
641203
158
134
93
84
97
86 652
641213
127
67
126
94
16
49 479
641216
141
141
79
75
62
71 569
644
eompaajr Saniti**). Does notconteln TSCfl CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS
________ _________________________________ BASELINE
ANIMAL NUMBER
~ SUCCESSIVE 10-MINUTE INTERVALS
I 2345
6
TOTAL
GROUP II: 0 mg/kg/day
641253
117
147 135
98
5 135 637
641266
153
148
138
100
99
75 713
641281
119
151
78
73
99
0 520
641294
141
154
30
4
89
4 422
641325
132
127
72
110 79
5
525
641331
99
132 75
28
25
5 364
641359
142
125
111
137
122
110 747
641364
141
127
105
13
18
4
408
641383
109
113
47
2
4
11 286
641400
144
137
121
56
21
6 485
GROUP IV: 50 mg/kg/day
641260
119
130 144
120
66
23
602
641298
115
134
124
37
114 117 641
641311
134
133
95
2
16
1 381
641312
56
65
61
56
51
64 353
641313
135
131
132
116
129
90
733
641336
115
131
126
108
123
38
641
641355
138
151
140
155
156
123
863
641361
117
111
109
83
0
3 423
641369
139
137
114
94
3
5 492
641396
130
116
138
148
137
148
817
GROUP VI: 250 mg/kg/day
641244
133
22
46
0
5
0 206
641251
130
132
123
140
124
102
751
641269
104
108
107
99
133 125 676
641292
148
137
126
140
44
12 607
641302
119
112
137
144
154
93
759
641362
163
178
89
9
74 11 524
641363
157
72
3
6 , 12 0 250
641375
120
119
60
101 125
82
607
641379
101
110 127
131
52
13 534
641398
113
99
31 120 53
10 426
645
Company Sanitized. Does not contain TSCA CBS
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS
ANIMAL
num ber
I
BASELINE
SUCCESSIVE 10-MINUTE INTERVALS 23456
TOTAL
GROUP VIH: 1000 mg/kg/day
641234
115
135
144
136
138
162
830
641256
134
128
120
95
156 141 774
641282
166
138
94
73
2
4 477
641352
141
126
103
24
5
3 402
641356
148
105
5
49 75
91 473
641366
137
144 113
38
19
5 456
641377
117
122
5
2
10 7 263
641385
129
115
132
139
159
59
733
641387
126
135
142
147
20
3 573
641399
105
144
146
54
6
2 457
646
SanHteecf. Does not contain TSCA CB)
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS
ANIMAL NUMBER
I
WEEK 12
SUCCESSIVE 10-MINUTE INTERVALS 234 56
TOTAL
GROUP H: 0 mg/kg/day
641253
144
113
125
46
6
24 458
641266
107
137
115
15
9
75 458
641281
150
142
83
106 105
35
621
641294
134
154
141
184
129
9
751
641325
152
129
88
139 128 146 782
641331
131
139
120
82
97
79 648
641359
142
147
164
129
122
118
822
641364
127
166 133
38
23
95 582
641383
120
132
128
120
114
5
619
641400
135
139
92
98
161 127 752
GROUP IV: 50 mg/kg/day
641260
111
133
136
130
109
12
631
641298
140
138
124 128
75
1 606
641311
158
140
135
121
6
3 563
641312
114
153
93
139 103
9
611
641313
127
157
142
57
12 146 641
641336
133
112
116
99
159 118 737
641355
144
127
145
154 130
56
756
641361
115
115
133
14
13
2 392
641369
151
159
35
123
70
4 542
641396
138
136
131
112
49
131 697
GROUP VI: 250 mg/kg/day
641244
130
102
53
4
17
0 306
641251
133
127
84
114
94
83 635
641269
129
120
110
93
107 81
640
641292
147
138
145
62
8
10 510
641302
104
128
122
149
64
43 610
641362
167
154 167
129
42
13 672
641363
157
124
70
52
155
39
597
641375
126
136
123
135
108
23
651
641379
116
118
41
133 123
32
563
641398
131
144
90
132
68
40 605
647
Company SwKfeed. Does not contain TSCA CB
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS
_________ __________________________ WEEK 12
ANIMAL
num ber
~~ SUCCESSIVE 10-MINUTE INTERVALS
I 2345
6
TOTAL
G R O U P Vni: 1000 mg/kg/day
641234
127
132 128
102
154
74
717
641256
152
81
63
135 66
45 542
641282
152
145
88
27
54
3 469
641352
131
163
148
151
137
122 852
641356
152
136
29
28
132 31 508
641366
147
152
123
15
7
95 539
641377
142
111
86
18
21
6 384
641385
149
131
70
104
19
25 498
641387
130
107
12
85
86
27 447
641399
123
159
135
62
112 143 734
648
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS
ANIMAL
num ber
I
RECOVERY
SUCCESSIVE 10-MINUTE INTERVALS 23456
TOTAL
GROUP II: 0 mg/kg/day
641253
166
126
97
61
28 121 599
641266
137
126 134 134 133
77
741
641281
158
116
95
97
120 102 688
641294
131
131
106
141
92
130 731
641325
138
148
96
158 63
84 687
641331
136
122
90
78
62
82 570
641359
130
129
83
132 113
67
654
641364
141
124
51
100 62
24 502
641383
128
104
95
94
77
63 561
641400
168
132
86
121 92
88
687
GROUP VIII: 1000 mg/kg/day
641234
146
137
63
91
85
78 600
641256
154
106
80
75
83
85 583
641282
134
108
44
69
2
18 375
641352 641356
165 a
147
-
99
-
123 147
-_
94 .
775
641366
126
105
89
67
90 101 578
641377
127
96
68
44
43 156 534
641385
161
116
120
124
53
3 577
641387
140
118
119
37
81
124 619
641399
144
153
133
106
107
78
721
649
SanHbed. Does not contain TSCA C
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
APPENDIX J INDIVIDUAL ANIM AL CLINICAL PATHOLOGY DATA
650
Company Sanitized, Does not contain TSCA CB
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA
EXPLANATORY NOTES
ABBREVIATIONS :
General:
ADEQ - adequate
CLOT " sample clotted
DECR - decreased
NSR - no sample received for testing
NT - not taken or not performed
NT-HEMOL
not taken due to hemolysis greater than or
OK _ sample condition OK for testing
QNS - quantity not sufficient
RNV result not valid
> - greater than
< - less than
to moderate
Individual Hematology Values : COND - sample condition RBC - red blood cell count HGB - hemoglobin HCT - hematocrit MCV - mean corpuscular volume MCH - mean corpuscular hemoglobin MCHC - mean corpuscular hemoglobin concentration RDW - red cell distribution width ARET - absolute reticulocyte count WBC white blood cell count ANEU - absolute neutrophil (all forms) ANPR - absolute neutrophil precursor ALYM - absolute lymphocyte AMON _ absolute monocyte AEOS " absolute eosinophil ABAS - absolute basophil ALUC - absolute large unstained cell ABLT - absolute blast leukocyte AMSC - absolute miscellaneous leukocyte PLT - platelet count SPEC - special observations
Individual Red Blood Cell Morphology Values: NORM - normal
ANIS - anisocytosis
MIC - microcytes MAC - macrocytes
POLY - polychromasia
HYPO - hypochromasia ECHI - echinocytes
ACAN - acanthocytes TARG - target cells
RX - rouleaux
,
HJB - Howell-Jolly body
SPEC - special observations
-- - not observed or not examined; see whole blood sample condition
651
TM P atgr8anHfeed, Doe
contain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA
EXPLANATORY NOTES
ABBREVIATIONS :
Individual White Blood Cell / Platelet Morphology Values: NORM - normal SM - smudge white blood cells DB " Dohle bodies PC - platelet clumps (graded as 1 if present at any level) GP - giant platelets BP " bizarre platelets TOX _ toxic neutrophils VC - vacuolated cytoplasm SPEC - special observations
-- not observed or not examined; see whole blood sample condition
Individual PHEM PLIP PICT PT APTT
Coagulation Values: - plasma hemolysis - plasma lipemia - plasma icterus - prothrombin time - activated partial
thromboplastin
time
Individual Serum and Plasma Chemistry Values:
SHEM - serum hemolysis
SLIP
serum lipemia
SICT - serum icterus
AST - aspartate aminotransferase
ALT - alanine aminotransferase
SDH - sorbitol dehydrogenase
ALKP - alkaline phosphatase BILI - total bilirubin
BUN - urea nitrogen
CREA - creatinine
CHOL - cholesterol
TRIG - triglycerides
GLUC - glucose
TP - total protein
ALB - albumin
GLOB - globulin
CALC - calcium
IPHS - inorganic phosphorous
NA - sodium
K - potassium
CL - chloride
PHEM - plasma hemolysis from blood sample for fluoride determination
PLIP - plasma lipemia from blood sample for fluoride determination
PICT
plasma icterus from blood sample for fluoride determination
PFLU - plasma fluoride
652
S@mpm%Sanitized. Does not contain tsca crt
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA
EXPLANATORY NOTES
ABBREVIATIONS :
Individual Urinalysis Values:
QUAL - quality (modifies color)
COL - color
CLAR - clarity
VOL - volume
UOSM - urine osmolality
SG - specific gravity
pH - the logarithm of the reciprocal of the hydrogen ion concentration
UGLU
urine glucose
KET _ ketone
UBIL - urine bilirubin
BLD - blood
URO - urobilinogen
UFLU - urine fluoride
UMTP - urine protein
SPEC - special observations
Individual Urine Microscopic Examination Values: EPIT " epithelial cells UWBC " urine white blood cells URBC ~ urine red blood cells NCRY - normal crystals MICR - microorganisms SPER - sperm SPEC - special observations
KEY:
Red Blood Cell Morphology Values, White Blood Cell / Platelet Morphology Values the exception of Platelet Clumps), and Special Observations:
1 - trace 2 few 3 - moderate 4 - many
(with
Urine Microscopic Values :
EPIT/CASTS few - 1-10
moderate - 11-50 many - >50
NCRY/MICR few - 1-25%/field moderate - 26-50%/field many - >50%/field
SPERM/MUCUS
1 - 1-5 2 - 6-20 .3 - >20
653
w npf SanSfeed
CEI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA
NOTES:
EXPLANATORY NOTES
When individual animal data are not reported, it m a y be due to one of the following reasons or other reasons, all of which are explained in the study records:
the sample was clotted (for hematology or coagulation data) (CLOT) there was insufficient sample for analysis (QNS) a valid result could not be obtained (RNV) the sample was not suitable for evaluation the animal died prior to sample collection no sample was available for analysis (NSR)
When an individual observation was recorded as being less than a certain value, calculations were performed on half the recorded value. For example, if bilirubin was reported as <0.1, 0.05 was used for any calculations performed with that bilirubin data.
654
J
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________________________________________________________ DuPont-4739
INDIVIDUAL HEMATOLOGY VALUES FOR MALE RATS
Animal
COND
RBC
HGB
HCT
MCV
MCH MCHC
RDW ARET
WBC ANEU
Number
xlO"6//iL
g/dL
% fL pg g/dL
% xlOn3/h xlOn3/L x I O ^ / m L
Male, Group: I - 0 mg/kg - Day 44
641069
CLOT
NT
NT
NT
NT
NT
NT. NT
NT
NT
NT
641070
OK
8.39
15.6
50.8
60.5
18.6
30.7
11.2
216.
16.86
1.52
641094
OK
8.43
14.7
48.9
58.0
17.4
30.0
11.9
261.
12.56
1.46
641147
OK
8.09
15.3
48.4
59.8
18.9
31.5
11.2
202.
10.49
1.07
641149
OK
7.69
14.8
47.6
61.8
19.3
31.2
11.3
182.
16.69
1.72
I 641155 641172 641206 641214
OK
7.86
14.5
47.3
60.2
18.4
30.6
11.5
192.
13.16
1.63
OK
8.16
14.9
48.3
59.2
18.3
30.9
10.6
199.
13.18
1.98
OK
8.50
15.9
51.9
61.0
18.7
30.6
11.4
278.
12.40
2.76
OK
8.28
14.5
48.2
58.2
17.5
30.1
11.9
241.
12.15
2.28
641222
OK
8.21
15.1
48.9
59.5
18.4
30.9
12.5
237.
19.19
1.11
Male, Group: III - 50 mg/kg - Day 44
641055 641056 641073 641081 641144 641146 641178 641198 641218 641224
OK
8.07
15.6
49.9
61.8
19.4
31.3
11.2
198.
16.20
1.92
OK
7.71
14.6
46.5
60.3
18.9
31.4
12.1
244.
17.69
1.91
OK
8.00
14.9
47.5
59.4
18.7
31.4
11.3
195.
19.63
1.66
OK
8.21
14.9
48.7
59.3
18.1
30.6
11.6
231.
17.63
2.10
OK
7.79
15.5
47.3
60.8
19.9
32.8
10.8
203.
19.57
2.02
OK
8.43
15.1
50.3
59.6
18.0
30.1
11.6
209.
21.05
1.86
OK
8.10
14.5
47.6
58.7
18.0
30.6
10.9
176.
13.51
2.95
OK
8.58
14.6
48.8
56.9
17.0
29.9
11.9
212.
14.80
1.93
OK
7.55
14.6
45.1
59.8
19.3
32.4
12.4
268.
13.00
1.73
OK
8.28
14.6
48.7
58.9
17.6
30.0
11.1
225.
15.29
2.15
Doe*notconfarti ?c cb
655
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________
DuPont-4739
INDIVIDUAL HEMATOLOGY VALUES FOR MALE RATS
Animal
COND
RBC
HGB
HOT
MCV MCH MCHC
Number
xlOA6//tL
g/dL
%
fL pg
g/dL
RDW ARET
WBC ANEU
% xl0^3/fiL x ! 0 a3 / mL x 1 0 a3 / mL
Male, Group: V - 250 mg/kg - Day 44
641061 641089 641102 641134 641137 641162 641190 641197 641200 641202
OK OK OK OK OK OK OK OK OK OK
7.93 7.46 7.64 7.75 7.89 7.32 8.37 8.28 7.94 7.75
15.1 14.1 14.5 14.1 14.1 14.0 14.8 15.3 14.9 15.6
49.9 45.1 45.6 45.8 45.4 44.2 48.9 51.4 47.5 50.0
62.9 60.4 59.7 59.1 57.5 60.4 58.4 62.1 59.9 64.4
19.0 18.9 19.0 18.2 17.8 19.2 17.7 18.5 18.7 20.1
30.2 31.3 31.8 30.8 31.0 31.8 30.3 29.8 31.3 31.2
11.6 11.1 11.3 11.3 11.6 12.3 11.1 12.1 11.2 10.9
254. 180. 214. 176. 189. 250. 163. 201. 205. 250.
17.87 14.94 17.16 14.38 11.36 16.47 19.22 17.25 14.88 20.81
1.25 1.00 2.24 0.89 1.88 1.92 2.63 1.87 2.03 2.82
Male, Group: VII - 1000 mg/kg - Day 44
641067 641077 641086
f 641095 641097
I 641132
641157 641166 641201 641223
OK OK OK OK OK OK OK OK OK .OK
7.87 7.71 8.05 8.17 7.28 7.52 7.91 8.27 8.10 7.71
14.4 14.3 15.0 14.5 14.2 13.5 14.7 14.9 14.3 13.9
46.5 45.5 47.4 47.7 45.8 45.5 47.3 47.5 47.3 44.5
59.1 59.0 58.9 58.4 62.8 60.6 59.8 57.4 58.4 57.7
18.3 18.6 18.6 17.8 19.5 17.9 18.6 18.0 17.6 18.0
30.9 31.5 31.6 30.5 31.0 29.6 31.2 31.3 30.2 31.2
11.8 12.2 10.9 13.0 11.6 13.5 11.2 11.7 12.5 12.5
267. 228. 180. 237. 179. 333. 187. 191. 196. 187.
24.31 24.15 24.51 19.04 14.94 17.31
7.22 14.23 20.40 20.61
3.18 3.42 2.59 1.34 1.71 1.82 1.68 1.34 1.91 1.39
eonfaFrsTSCA CB!
656
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL HEMATOLOGY VALUES FOR MALE RATS
Animal Number
ANPR xlO-'3/m L
ALYM x 10a 3/m L
AMON xlO a3/m L
AEOS x 10a 3/m L
ABAS XlO A3/h
ALUC x 10a 3/m L
ABLT xlOA3//xL
AMSC
PLT
xl0A3/xL x !0a3/m L
Male, Group: I - 0 mg/kg - Day 44
641069 NT NT NT NT NT NT NT NT NT
641070
NT 14.59
0.29
0.12
0.13
0.23
NT
NT 1133
641094
NT 10.42
0.21
0.08
0.14
0.25
NT
NT RNV
641147 NT 8.97 0.21 0.04 0.05 0.15 NT NT RNV
641149
NT 14.25
0.25
0.16
0.14
0.16
NT
NT 1177
641155
NT 10.97
0.25
0.09
0.09
0.12
NT
NT 1063
641172
NT 10.43
0.14
0.33
0.08
0.23
NT
NT RNV
641206 NT 8.59 0.25 0.18 0.13 0.49 NT NT 1271
641214 NT 8.72 0.44 0.53 0.09 0.09 NT NT RNV
641222
NT 16.97
0.34
0.12
0.20
0.45
NT
NT 1147
Male, Group: III - 50 mg/kg - Day 44
641055
NT 13.62
0.30
0.11
0.14
0.11
NT
NT 1080
641056
NT 14.91
0.45
0.17
0.09
0.16
NT
NT RNV
641073
NT 17.19
0.29
0.11
0.11
0.26
NT
NT RNV
641081
NT 14.76
0.31
0.12
0.12
0.21
NT
NT 1331
641144
NT 16.33
0.52
0.17
0.21
0.33
NT
NT RNV
641146
NT 18.20
0.35
0.21
0.14
0.30
NT
NT 1244
641178 NT 9.81 0.34 0.15 0.06 0.20 NT NT 1133
641198
NT 12.05
0.42
0.15
0.06
0.20
NT
NT 1095
641218
NT 10.59
0.25
0.07
0.07
0.30
NT
NT 1232
641224
NT 12.01
0.57
0.22
0.04
0.30
NT
NT RNV
SPEC
- t - 's
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL HEMATOLOGY VALUES FOR MALE RATS
Animal Number
ANPR
ALYM
AMON
AEOS
ABAS
ALUC
ABLT
AMSC
x ! 0 A3 / mL xI O ^ / mL x1 0 a3 / mL x1 0 a3 / mL x1 0 - '3 / mL x 1 0 " 3 / mL xI O ^ / mL xlO^/L
PLT x 1 0 " 3 / mL
Male, Group: V - 250 mg/kg - Day 44
641061 641089 641102 641134 641137 641162 641190 641197 641200 641202
NT 15.67 NT 13.19 NT 14.27 NT 12.89 NT 8.91 NT 13.81 NT 15.59 NT 14.57 NT 12.23 NT 17.24
0.35 0.31 0.34 0.23 0.26 0.37 0.50 0.35 0.28 0.25
Male, Group: VII - 1000 mg/kg ~ Day 44
641067 641077 641086 641095 641097 641132 641157 641166 641201 641223
NT. 19.85 NT 19.17 NT 20.18 NT 16.97 NT 12.57 NT 14.75 NT 4.79 NT 12.19 NT 17.79 NT 18.52
0.53 0.33 0.76 0.25 0.33 0,26 0.16 0.37 0.27 0.29
0.12 0.09 0.10 0.08 0.08 0.05 0.16 0.07 0.08 0.16
0.12 0.12 0.15 0.10 0.08 0.09 0.50 0.07 0.13 0.09
0.15 0.13 0.09 0.14 0.08 0.11 0.11 0.18 0.07 0.15
0.29 0.16 0.23 0.14 0.10 0.16 0.04 0.08 0.15 0.12
0.33 0.22 0.11 0.15 0.14 0.21 0.23 0.22 0.19 0.18
0.35 0.95 0.60 0.23 0.14 0.22 0.05 0.19 0.16 0.20
NT NT 1173 NT- NT RNV NT NT RNV NT NT 1082 NT NT 1214 NT NT 1025 NT NT 900 NT NT 894 NT NT 822 NT NT 904
NT NT 1051 NT NT 1150 NT NT 898 NT NT 1220 NT NT 1094 NT NT 1234 NT NT RNV NT NT 980 NT NT 995 NT NT 987
SPEC
-D oes nof contain TSCACBI
658
J
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL HEMATOLOGY VALUES FOR MALE RATS
Animal Number
COND
RBC
x IO^/mL
HGB 9 /dL
Male, Group: I - 0 mg/kg - Day 91
641069 641070 641094 641147 641149 641155 641172 641206 641214 641222
OK 8.56 15.1 OK 8.75 16.1 OK 8.99 15.7 OK 8.60 16.4 OK 8.63 16.2 OK 8.36 15.2 OK 8.79 15.7 OK 9.02 16.5 OK 9.05 15.4 OK 8.63 15.4
Male, Group: III - 50 mg/kg - Day 91
641055 641056 641073 641081 641144 641146 641178 641198 641218 641224
OKT 8.96 OK 8.25 OK 8.93 OK 10.05 OK 8.67 OK 8.82 OK 9.33 OK 8.76 OK 7.96 OK 8.66
16.8 14.8 16.0 17.5 15.9 15.7 16.3 14.7 15.2 15.2
HCT %
48.0 50.0 49.6 49.8 50.4 47.5 49.7 52.1 49.3 48.9
52.1 47.1 49.9 55.5 50.1 48.3 51.9 47.3 45.0 47.8
MCV fL
56.1 57.1 55.1 57.9 58.4 56.8 56.6 57.8 54.5 56.7
58.2 57.1 55.9 55.2 57.8 54.7 55.6 54.0 56.5 55.3
MCH pg
17.7 18.4 17.5 19.1 18.7 18.2 17.8 18.3 17.0 17.9
18.7 17.9 18.0 17.4 18.3 17.7 17.4 16.7 19.1 17.6
MCHC g/dL
31.5 32.2 31.7 32.9 32.0 32.0 31.5 31.7 31.2 31.5
32.1 31.4 32.1 31.6 31.7 32.4 31.3 31.0 33.7 31.8
RDW ARET
WBC ANEU
% xIO^/mL xIO^/mL xIO^/mL
12.6 12.0 13.1 11.7 12.3 12.3 11.1 11.9 13.2 12.9
12.1 12.5 12.2 12.3 11.9 12.3 11.9 13.9 12.2 11.9
204. 147. 235. 153. 148. 178. 185. 233. 235. 205.
13.89 10.79
9.17 9.67 11.86 9.54 13.47 9.37 10.58 14.23
177. 223. 211. 215. 182. 163. 180. 243. 216. 237.
11.62 14.02 14.37 11.25 11.38 14.69 14.54 12.40 12.30 13.96
1.48 1.21 1.51 1.18 1.77 1.67 1.34 1.60 1.75 0.97
1.99 2.58 1.43 2.40 1.62 1.32 2.71 1.54 1.72 1.99
I. Does not contain TSCA CBI
659
J
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL HEMATOLOGY VALUES FOR MALE RATS
Animal
COND
RBC
HGB
HCT
MOV
MCH MCHC
RDW ARET
WBC ANEU
Number
x !0a 6/m L
g/dL
% fL pg g/dL
% x ! 0 a3 / mL x 1 0 a3 / mL x 1 0 a3 / mL
Male, Group: V - 250 mg/kg - Day 91
ompany s ntfeed. Does not contain
641061 641089 641102 641134 641137 641162 641190 641197 641200 641202
OK 9.12 16.7 OK 8.16 14.8 OK 8.21 15.2 OK 8.73 15.9 OK 9.08 15.8 OK 8.36 15.2 OK 8.92 15.6 OK 9.01 16.1 OK 9.05 15.9 OK 8.66 16.7
Male, Group: VII - 1000 mg/kg - Day 91
54.4 46.0 46.8 49.4 49.9 48.2 48.8 50.1 50.6 52.4
59.7 56.4 57.1 56.6 55.0 57.7 54.7 55.6 55.9 60.5
18.3 18.2 18.6 18.2 17.5 18.2 17.4 17.9 17.6 19.3
30.7. 32.2 32.5 32.2 31.8 31.6 31.9 32.1 31.4 31.9
12.7 12.3 12.0 11.3 12.2 12.3 12.5 12.3 12.1 11.3
228. 151. 125. 143. 152. 160. 110. 149. 179. 189.
11.67 13.57
9.83 11.75 11.10 14.30 18.00
9.24 12.64 15.10
1.11 1.12 1.40 1.76 1.62 1.34 1.85 1.26 1.23 1.85
641067 641077 641086 641095 641097 641132 641157 641166 641201 641223
OK OK OK OK OK OK OK OK OK
, OK
8.46 8.05 9.06 8.28 7.80 8.3 8.66 9.14 8.91 8.33
15.2 14.1 15.8 14.6 15.0 14.8 16.2 15.7 15.4 15.0
47.0 44.8 50.2 45.6 45.6 47.4 50.8 50.0 49.0 47.2
55.6 55.7 55.5 55.1 58.5 57.1 58.6 54.7 54.9 56.6
18.0 17.6 17.4 17.7 19.2 17.8 18.7 17.1 17.3 18.0
32.4 31.5 31.4 32.1 32.8 31.2 31.9 31.3 31.5 31.7
11.7 13.9 11.6 13.0 13.2 12.7 11.5 12.6 12.3 13.5
76. 197. 113. 158. 168. 196. 132. 150. 102. 176.
16.73 16.87 16.56 13.84
9.26 13.68
8.26 9.20 14.67 16.35
1.33 3.40 1.42 1.98 1.27 1.34 1.19 1.09 1.80 1.36
2O
660
n p a v Sanitized. Does not contain TSCA CBf
J
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL HEMATOLOGY VALUES FOR MALE RATS
Animal Number
ANPR xl0A3//L
ALYM x 10a 3/m L
AMON x 10a 3/m L
AEOS
ABAS
xlOA3/fL x !0a 3/mL
ALUC
ABLT
xlOA3/,uL x 10a 3/m L
AMSC
PLT
xlOA3/iiL x !0a 3/m L
Male, Group: I - 0 mg/kg - Day 91
641069 641070 641094 641147 641149 641155 641172 641206 641214 641222
NT 11.54 NT 9.05 NT 7.00 NT 8.04 NT 9.57 NT . 7.36 NT 11.39 NT 7.25 NT 8.08 NT 12.53
0.43 0.29 0.29 0.25 0.35 0.25 0.25 0.19 0.42 0.36
Male, Group: III - 50 mg/kg - Day 91
641055 641056 641073 641081 641144 641146 641178 641198 641218 641224
NT 8.96 NT 10.67 NT 12.18 NT 8.17 NT 8.80 NT 12.79 NT 11.05 NT 10.18 NT 9.83 ,NT 10.96
0.21 0.41 0.29 0.43 0.51 0.22 0.41 0.34 0.40 0.52
0.27 0.10 0.14 0.06 0.09 0.17 0.15 0.17 0.11 0.14
0.17 0.21 0.17 0.08 0.23 0.17 0.13 0.19 0.15 0.23
0.07 0.05 0.11 0.05 0.04 0.03 0.13 0.08 0.10 0.10
0.13 0.06 0.13 0.06 0.07 0.10 0.11 0.06 0.05 0.15
0.10 0.09 0.11 0.09 0.05 0.06 0.22 0.08 0.13 0.14
0.15 0.08 0.17 0.12 0.15 0.10 0.14 0.08 0.14 0.09
NT. NT 1259 NT NT 1133 NT NT 1110 NT NT 1083 NT NT 1177 NT NT RNV NT NT RNV NT NT 1188 NT NT 879 NT NT 1221
NT NT 1018 NT NT 1022 NT NT 1063 NT NT RNV NT NT RNV NT NT 1032 NT NT 1162 NT NT 1006 NT NT RNV NT NT 1087
SPEC
661
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________________________________________________
DuPont-4739
INDIVIDUAL HEMATOLOGY VALUES FOR MALE RATS
Animal
ANPR
ALYM
AMON
Number x 10a 3/m L x I O ^ / m L x I O ^ / mL
AEOS
ABAS
ALUC
ABLT
x 1 0 a3 / mL x ! 0 a3 / mL x 1 0 ~ 3 / mL x 1 0 ~ 3 / mL
AMSC x 1 0 a3 / mL
PLT x ! 0 a3 / mL
Male, Group: V - 250 mg/kg - Day 91
641061 641089 641102 641134 641137 641162 641190 641197 641200 641202
NT 9.85 NT 11.78 NT 7.84 NT 9.43 NT 8.87 NT 12.43 NT 15.38 NT 7.57 NT 10.67 NT 12.51
0.21 0.30 0.30 0.37 0.28 0.27 0.39 0.22 0.37 0.29
Male, Group: VII - 1000 mg/kg - Day 91
641067 641077 641086 641095 641097 641132 641157 641166 641201 641223
NT- 14.44 NT 12.86 NT 14.35 NT 11.17 NT 7.44 NT 11.58 NT 6.69 NT 7.53 NT 12.14 NT 14.10
0.41 0.26 0.29 0.45 0.23 0.31 0.21 0.26 0.31 0.42
0.38 0.13 0.16 0.10 0.12 0.07 0.15 0.12 0.08 0.20
0.15 0.16 0.16 0.10 0.10 0.09 0.06 0.06 0.16 0.14
0.03 0.10 0.03 0.04 0.11 0.08 0.09 0.04 0.13 0.14
0.16 0.09 0.16 0.03 0.11 0.17 0.05 0.12 0.15 0.07
0.08 0.13 0.09 0.04 0.10 0.11 0.14 0.04 0.15 0.11
0.23 0.10 0.18 0.11 0.11 0.19 0.05 0.15 0.12 0.26
NT NT RNV NT- NT 1290 NT NT 845 NT NT 1052 NT NT 1217 NT NT 990 NT NT 850 NT NT 946 NT NT 717 NT NT 840
NT NT 830 NT NT 1137 NT NT 815 NT NT RNV NT NT RNV NT NT 1048 NT NT 909 NT NT 902 NT NT 792 NT NT 997
SPEC
of contain TSCA CB!
662
J
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations__________________
DuPont-4739
INDIVIDUAL HEMATOLOGY VALUES FOR MALE RATS
Animal Number
COND
RBC
xl0A6/ML
HGB g/dL
Male, Group: I - 0 mg/kg - Day 123
641083 641084 641085 641101 641105 641123 641154 641159 641165 641215
OK 8.67 15.5 OK 8.96 15.4 OK 8.24 14.9 OK 8.67 14.5 OK 8.47 14.7 OK 8.80 14.6 OK 8.93 14.6 OK 9.07 16.2 OK 8.42 14.7 OK 8.29 14.7
Male, Group: VII - 1000 mg/kg - Day 123
641064 641092 641143 641153 641167 641185 641189 641203 641213 641216
OKOK OK OK OK OK OK OK OK
.OK
8.83 8.10 8.72 8.83 8.69 8.57 7.92 7.97 8.44 8.67
15.9 14.1 14.8 14.4 15.2 15.4 13.3 14.2 14.4 14.5
HCT %
48.3 47.4 45.4 45.5 45.2 45.4 45.8 48.8 46.3 45.2
50.2 44.0 46.4 43.9 46.5 47.6 41.7 44.8 44.7 45.0
MCV L
55.7 52.9 55.1 52.5 53.4 51.5 51.3 53.8 55.0 54.5
56.9 54.4 53.1 49.7 53.5 55.5 52.6 56.1 53.0 51.9
MCH pg
17.8 17.2 18.1 16.7 17.3 16.6 16.4 17.8 17.5 17.7
18.1 17.4 17.0 16.4 17.4 17.9 16.8 17.8 17.1 16.8
MCHC g/dL
RDW ARET
WBC ANEU
% x 10a 3/m L x 10a3/m L xlOA3/fL
32.0 32.532.8 31.8 32.5 32.3 31.9 33.2 31.8 32.5
12.9 13.5 12.7 13.6 13.6 14.1 13.6 13.4 13.1 13.8
31.7 32.0 32.0 32.9 32.6 32.3 31.9 31.7 32.3 32.3
13.1 14.7 14.7 14.1 13.4 13.1 13.5 13.2 12.5 14.8
228. 179. 154. 194. 175. 182. 171. 201. 166. 184.
9.37 16.28 15.20 10.37 13.15 13.52 12.18 18.48 16.27 13.67
186. 196. 158. 158. 176. 203. 154. 151. 170. 222.
12.21 14.15 14.04 12.40 14.83 15.95 14.31 12.28 12.25 11.04
1.41 2.14 2.24 0.73 1.61 2.39 1.62 2.66 1.73 1.88
2.00 1.80 2.78 1.69 1.66 1.84 1.80 4.02 1.36 2.63
no*contain TSCA CBI
663
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL HEMATOLOGY VALUES FOR MALE RATS
Animal Number
ANPR x 10a 3/m L
ALYM xlO *3/L
AMON xlO*3//*L
AEOS xlO*3//L
ABAS xl0n3/fiL
ALUC x IO^/mL
ABLT xlO*3/iiL
AMSC
PLT
xlO''3/L x 1(T3/m L
SPEC
Male, Group : I - 0 mg/kg - Day 123
CompanySanitized. Does
641083 641084
NT 7.23 NT 12.99
0.32 0.08
0.17 0.39
0.07 0.10
0.17 0.57
NT NT
NT 851 NT 1158 Sample Status : VOLUME
SIGNIFICANTLY
DIFFERENT THAN
641085 641101 641105 641123 641154 641159 641165 641215
NT 11.97 NT 8.96 NT 10.76 NT 10.38 NT 9.79 NT 14.98 NT 13.56 NT 10.99
0.38 0.29 0.38 0.22 0.35 0.47 0.29 0.39
0.19 0.10 0.12 0.13 0.07 0.09 0.17 0.11
0.06 0.14 0.06 0.21 0.17 0.17 0.22 0.21
0.37 0.15 0.21 0.18 0.18 0.11 0.31 0.09
NT NT NT NT NT NT NT NT
SPECIFIED NT 933 NT 1031 NT 1206 NT 1115 NT RNV NT RNV NT RNV NT 1123
Male, Group: VII - 1000 mg/kg - Day 123
I03
300 3
641064 641092 641143 641153 641167 641185 641189 641203 641213 641216
NT 9.43 NT 11.59 NT 10.25 NT 9.81 NT 12.21 NT 13.28 NT 11.67 NT 7.43 NT 10.31 NT 7.45
0.27 0.36 0.33 0.34 0.37 0.30 0.31 0.40 0.28 0.34
0.24 0.11 0.12 0.08 0.12 0.33 0.13 0.07 0.11 0.14
0.11 0.17 0.42 0.31 0.29 0.09 0.17 0.26 0.06 0.12
0.15 0.12 0.15 0.16 0.17 0.11 0.23 0.11 0.12 0.36
NT NT NT NT NT NT NT NT NT NT
NT RNV NT 1083 NT 989 NT 837 NT 1027 NT 1062 NT 905 NT 911 NT 664 NT 860
8
664
agf g j|
s
1
f
n Q
g
3 O O o 3 Si
S
Ai o is.
a
*83S,r
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL HEMATOLOGY VALUES FOR FEMALE RATS
Animal Number
COND
RBC
x 10/'6/m L
HGB g/dL
Female, Group: II - 0 mg/kg - Day 44
641240 641245 641249 641257 641283 641290 641293 641335 641344 641384
OK 7.92 15.3 OK 8.48 15.9 OK 7.86 14.9 OK 7.97 15.2 OK 8.46 15.6 OK 7.91 14.9 OK 8.29 15.3 OK 8.52 15.6 OK 7.49 15.1 OK 8.25 15.6
Female, Group: IV - 50 mg/kg - Day 44
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
OK. 7.97 OK 7.62 OK 7.66 OK 7.61 OK 7.69 OK 7.85 OK 7.63 OK 8.45 OK 8.07 OK 7.74
15.1 14.5 15.2 14.3 13.7 15.0 14.1 16.2 14.5 14.8
HCT %
47.9 50.4 47.1 51.0 51.3 48.5 49.1 50.5 48.5 49.5
47.0 46.9 48.1 45.0 44.6 47.8 45.6 51.6 47.9 47.9
MCV fL
60.5 59.5 59.9 64.0 60.6 61.3 59.2 59.2 64.8 60.0
58.9 61.6 62.8 59.1 58.1 60.9 59.7 61.1 59.4 61.9
MCH pg
19.3 18.7 19.0 19.0 18.4 18.8 18.4 18.3 20.1 18.9
19.0 19.0 19.9 18.7 17.9 19.1 18.5 19.2 18.0 19.1
MCHC g/dL
RDW ARET
WBC ANEU
% xl O ^ / a L x !0-'3/m L x l O^/aL
32.0 31.5. 31.7 29.7 30.4 30.7 31.1 30.9 31.1 31.4
11.2 10.7 11.0 11.1 10.6 11.5 10.9 11.5 10.8 10.6
32.2 30.8 31.6 31.7 30.8 31.3 30.9 31.3 30.2 30.8
11.2 12.2 10.9 11.6 10.7 11.1 10.8 12.4 11.1 11.6
251. 179. 175. 299. 244. 202. 171. 195. 250. 150.
17.32 10.54
9.27 16.70 10.17 14.57 14.97 14.44 17.04 13.67
263. 204. 174. 319. 192. 205. 194. 245. 202. 221.
10.90 16.10 11.64
9.69 16.45 13.05 12.76 14.13 16.36 10.93
1.40 1.34 1.03 2.54 1.33 1.49 1.80 0.77 1.17 1.04
0.54 0.63 0.93 0.93 0.87 1.64 1.44 0.96 1.28 2.08
665
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________
DuPont-4739
INDIVIDUAL HEMATOLOGY VALUES FOR FEMALE RATS
Animal Number
COND
RBC
X1CT6/ML
HGB g/dL
Female, Group: VI - 250 mg/kg - : 44
641244 641251 641269 641292 641302 641362 641363 641375 641379 641398
OK 7.52 14.6 OK 7.27 14.0 OK 8.34 14.8 OK 7.75 15.0 OK 7.63 14.7 OK 7.28 14.1 OK 7.54 13.7 OK 8.14 15.3 OK 7.31 14.2 OK 8.30 15.2
Female, Group: VIII - 1000 mg/kg Day 44
641237 641275 641279 641299 641300 641314 641326 641327 641380 641390
OK- 7.75 OK 8.00 OK 7.61 OK 7.74 OK 7.49 OK 7.89 OK 7.78 OK 7.77 OK 7.47 OK 7.50
14.7 15.2 14.9 15.5 14.2 14.8 15.0 14.8 14.3 15.1
HCT %
44.7 44.2 48.1 45.1 45.5 44.1 43.7 47.3 45.4 49.2
47.1 48.8 47.7 48.0 43.4 47.1 47.7 47.1 45.9 47.4
MCV fL
59.4 60.8 57.7 58.2 59.6 60.5 58.0 58.2 62.2 59.3
60.9 60.9 62.7 62.0 57.9 59.6 61.3 60.6 61.4 63.3
MCH pg
MCHC g/dL
RDW ARET
WBC ANEU
% x!0A3/aL xlOA3//xL x !0a 3/m L
19.4 19.2 17.8 19.4 19.3 19.3 18.1 18.8 19.4 18.3
19.0 19.0 19.6 20.1 18.9 18.7 19.2 19.1 19.2 20.1
32.6 31.730.8 33.3 32.4 31.9 31.3 32.3 31.1 30.9
10.1 12.1 11.9 10.8 11.0 12.1 11.3 10.2 11.9 10.9
31.1 31.1 31.2 32.4 32.7 31.4 31.4 31.5 31.3 31.8
11.0 11.1 10.9 11.1 11.2 11.1 11.5 11.5 12.0 11.2
184. 225. 238. 235. 232. 238. 251. 189. 274. 194.
16.53 9.77
16.02 11.91 12.28
8.91 11.34 17.44
9.71 19.27
187. 242. 242. 284. 230. 238. 223. 197. 312. 255.
9.69 10.32 14.07 17.72 14.12 21.78 11.88 13.57 11.95 11.92
1.97 1.86 1.39 1.58 1.41 1.20 1.78 1.00 1.14 1.63
1.29 1.09 1.03 2.85 0.99 2.10 1.26 1.23 2.26 1.66
t e a ta * uiejuo }ou ssoQ
666
(80 3SX u|B*i!0sim m q "gmisuBg&mmmQ
J
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL HEMATOLOGY VALUES FOR FEMALE RATS
Animal
ANPR
ALYM
AMON
AEOS
ABAS
ALUC
ABLT
AMSC
PLT
Number x 1 0 a3 / mL xlOA3/h xl0A3/fiL xl0A3//iL x 1 0 a3 / kL xl0A3//iL x 1 0 a3 / mL x 1 0 a3 / L xl0A3/aD
Female, Group: II - 0 mg/kg - Day 44
641240
NT 15.04
0.30
0.12
0.13
0.33
NT
NT 1028
641245 NT 8.65 0.22 0.10 0.08 0.15 NT NT RNV
641249 NT 7.66 0.28 0.14 0.06 0.10 NT NT 875
641257
NT 13.19
0.36
0.23
0.10
0.28
NT
NT RNV
641283 NT 8.15 0.24 0.13 0.16 0.16 NT NT 1419
641290
NT 12.19
0.32
0.15
0.12
0.31
NT
NT RNV
641293
NT 12.04
0.22
0.24
0.08
0.59
NT
NT 1190
641335
NT 12.84
0.34
0.20
0.15
0.15
NT
NT RNV
641344
NT 15.26
0.23
0.13
0.09
0.16
NT
NT 765
641384
NT 11.76
0.29
0.26
0.09
0.24
NT
NT RNV
Female, Group: IV - 50 mg/kg - Day 44
641260
NT' 9.70
0.44
0.22
0.00
0.00
NT
NT RNV
641298
NT 15.03
0.17
0.10
0.06
0.12
NT
NT 1266
641311
NT 10.17
0.17
0.06
0.13
0.17
NT
NT RNV
641312 NT 8.39 0.09 0.16 0.04 0.08 NT NT 1169
641313
NT 14.92
0.21
0.09
0.11
0.24
NT
NT 888
641336
NT 10.73
0.29
0.05
0.14
0.20
NT
NT 917
641355
NT 10.67
0.24
0.06
0.15
0.19
NT
NT 1208
641361
NT 12.15
0.40
0.19
0.14
0.29
NT
NT 977
641369
NT 14.12
0.43
0.12
0.09
0.31
NT
NT 1242
641396
,NT 8.20 0.28 0.12 0.05 0.20
NT
NT 1007
DuPont-4739
667
Sanfifeed. Does not contain TSCA CB
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL HEMATOLOGY VALUES FOR FEMALE RATS
Animal
ANPR
ALYM
AMON
AEOS
ABAS
ALUC
ABLT
AMSC
PLT
Number x I O ^ / m L x io^/aL xl0A3/fiL xlOA3/itL xl0A3/tiL x I O ^ / m L x I O ^ / m L x I O ^ / m L xlOn3/h
Female, Group: VI - 250 mg/kg - Day 44
641244
NT 13,86
0.34
0.12
0.10
0.15
NT
NT 850
641251 NT 7.33 0.20 0.39 0.00 0.00 NT NT 1110
641269
NT 13.42
0.44
0.14
0.18
0.45
NT
NT 1017
641292 NT 9.72 0.20 0.20 0.04 0.15 NT NT KNV
641302
NT 10.19
0.18
0.16
0.12
0.23
NT
NT 994
641362 NT 7.22 0.20 0.08 0.07 0.15 NT NT RNV
641363 NT 9.07 0.17 0.13 0.05 0.13 NT NT RNV
641375
NT 15.57
0.19
0.27
0.12
0.28
NT
NT RNV
641379 NT 8.01 0.21 0.15 0.10 0.11 NT NT 1128
641398
NT 16.72
0.39
0.16
0.12
0.25
NT
NT 1223
Female, Group: VIII - 1000 mg/kg - Day 44
641237
NT- 7.90
0.15
0.16
0.08
0.12
NT
NT 1324
641275 NT 8.85 0.15 0.10 0.06 0.08 NT NT 1363
641279 641299
NT 12.46 NT 14.15
0.15 0.29
0.13 0.13
0.06 0.12
0.23 0.18
NT NT
NT 922 NT 1211
641300 641314
NT 11.98 NT 18.62
0.09 0.37
0.83 0.16
0.04 0.18
0.19 0.35
NT NT
NT RNV NT 1217
641326 641327 641380 641390
NT 9.78 NT 11.69 NT 9.29 NT 9.57
0.31 0.27 0.17 0.22
0.18 0.07 0.04 0.10
0.11 0.08 0.06 0.16
0.26 0.24 0.13 0.21
NT NT NT NT
NT RNV NT RNV NT 1297 NT 791
DuPont-4739
668
j
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats witl^One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL HEMATOLOGY VALUES FOR FEMALE RATS
Animal
COND
RBC
HGB
HCT
MCV MCH MCHC
NUffliber
Xio-S/ML
g/dh
%
L pg
g/dL
RDW ARET
WBC ANEU
% xlOn3/uL X1CT3/ML xlOA3/itL
pom pany SanKfeed. De not contain TSCA
Female, Group: II - o
Day 92
641240 641245 641249 641257 641283 641290 641293 641335 641344 641384
OK 8.45 OK 8.87 OK 8.52
o k 8.35 OK 8.56 OK 8.09 OK 8.76 OK 8.56 OK 8.37 OK 8.58
Female, Group: IV - 50 mg/kg - Day
KD to
16.0 16.3 15.5 15.9 15.9 15.2 16.2 15.8 16.5 15.9
49.3 51.6 49.5 49.7 50.5 47.6 50.8 49.0 52.5 49.8
58.3 58.1 58.1 59.5 59.0 58.8 58.1 57.2 62.7 58.1
19.0 18.4 18.1 19.1 18.5 18.7 18.4 18.5 19.7 18.6
32.5 31.6 31.2 32.0 31.4 31.9 31.8 32.3 31.4 31.9
10.7 10.8 11.3 10.6 10.6 11.6 10.8 10.8 10.6 10.0
155. 117. 179. 200. 215. 142. 138. 103. 187. 98.
8.13 7.14 7.23 10.42 9.16 10.75 9.50 7.65 8.61 8.17
0.94 0.73 1.48 0.90 1.61 0.92 0.82 0.64 0.81 0.40
aO
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
OK' OK OK OK OK
ok
OK OK OK OK
8.48 8.09 8.16 8.01 8.14 8.22 8.24 8.50 8.28 8.16
15.9 15.4 16.0 15.1 14.3 15.3 15.4 16.3 14.8 15.8
49.4 47.9 49.4 46.3 45.3 49.4 47.5 50.1 47.1 48.8
58.3 59.1 60.5 57.8 55.6 60.1 57.6 59.0 56.9 59.8
18.7 19.1 19.6 18.8 17.6 18.6 18.7 19.2 17.9 19.4
32.1 32.2 32.4 32.6 31.6 30.9 32.5 32.5 31.5 32.4
10.6 11.0 10.2 10.3 10.4 10.7 10.6 11.5 10.4 10.2
144. 145. 117. 210. 129. 152. 138. 178. 127. 118.
10.64 9.68 7.40 6.91
11.27 8.59 7.74 7.31 9.51 9.39
0.74 0.90 0.84 1.12 1.20 0.52 1.07 0.79 0.58 1.54
669
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL HEMATOLOGY VALUES FOR FEMALE RATS
Animal Number
COND
RBC
xlOA6/iiL
HGB g/dL
Female, Group: VI - 250 mg/kg - Day 92
641244 641251 641269 641292 641302 641362 641363 641375 641379 641398
OK 8.40 15.5 OK 7.96 14.8 OK 9.16 16.2 OK 8.25 15.7 OK 8.41 15.7 OK 7.72 14.8
OK 7.92 14.5 OK 8.34 15.5
OK 7.89 15.2
OK 8.81 15.9
Female, Group: VIII - 1000 mg/kg - Day 92
641237 641275 641279 641299 641300 641314 641326 641327 641380 641390
OK- 8.01 OK 8.32 OK 8.24 OK 8.05 OK 7.92 OK 8.25 OK 8.17 OK 8.36 OK 8.02 OK 8.15
15.2 15.9 15.8 16.2 14.4 15.5 15.8 15.8 15.7 16.2
HOT %
49.0 46.7 53.1 48.6 49.5 46.0 45.2 49.2 47.6 50.3
47.1 49.8 49.9 48.3 45.6 47.5 48.4 49.2 48.2 49.5
MOV fL
58.4 58.7 57.9 58.8 58.9 59.6 57.0 59.0 60.3 57.1
58.7 59.8 60.5 60.0 57.6 57.6 59.3 58.9 60.1 60.7
MCH
pg
18.4 18.6 17.7 19.0 18.6 19.2 18.3 18.6 19.2 18.1
19.0 19.1 19.2 20.1 18.3 18.8 19.3 18.9 19.5 19.9
MCHC g/dL
31.6 31.6' 30.6 32.2 31.7 32.3 32.2 31.6 31.8 31.7
32.3 31.9 31.6 33.6 31.7 32.5 32.6 32.1 32.5 32.7
RDW ARET
me ANEU
% x 10~3/mL xlO^/iit, x 10 3/m L
9.8 10.6 11.0 10.4 10.4 10.7 10.7 10.8 11.1 10.6
10.8 10.5 10.7 10.4 10.6 10.5 10.9 11.2 10.4 11.0
170. 160. 176. 192. 162. 179. 151. 178. 188. 170.
12.10 8.39
12.25 8.41 9.87 7.94
10.94 13.19
7.18 12.62
208. 163. 152. 246. 153. 151. 170. 158. 136. 196.
6.24 7.39 9.83 10.96 17.04 11.64 11.45 9.65 7.36 9.84
1.20 0.78 4.78 0.82 0.67 0.96 1.20 0.81 1.01 1.08
0.62 0.65 0.90 1.54 1.78 1.43 0.83 1.46 1.40 0.92
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
ft
s
5
m
g
,
0
O
fl
am
A3o\e3lr
5*
<n 9
mO
INDIVIDUAL HEMATOLOGY VALUES FOR FEMALE RATS
Animal Number
ANPR x 10a 3/L
ALYM x 1 0 a3 / mL
AMON
AEOS
ABAS
ALC
xlOA3/fiL x !0a3/m L x I O ^ / m L xlO'-l/L
ABLT
AMSC
PLT
xl0~3/itL x 10a 3/m L xlOA3/aL
Female, Group: II - 0 mg/kg - Day 92
641240 641245 641249 641257 641283 641290 641293 641335 641344 641384
NT 6.76 0.19 NT 5.90 0.26 NT 5.24 0.21 NT 8.98 0.20 NT 6.86 0.31 NT 9.08 0.39 NT 8.18 0.17 NT 6.45 0.20 NT 7.40 0.16 NT 7.16 0.20
Female, Group: IV - 50 mg/kg - Day 92
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
NTNT NT NT NT 0.00 NT NT NT NT
9.33 8.34 6.27 5.44 9.66 7.82 6.31 6.04 8.51 7.35
0.20 0.16 0.13 0.15 0.18 0.26 0.21 0.19 0.19 0.20
0.09 0.13 0.19 0.21 0.11 0.14 0.14 0.19 0.14 0.26
0.13 0.08 0.07 0.10 0.11 0.00 0.07 0.10 0.11 0.14
0.07 0.05 0.05 0.08 0.14 0.11 0.09 0.08 0.05 0.04
0.09 0.08 0.05 0.07 0.04 0.00 0.03 0.07 0.05 0.06
0.09 0.07 0.05 0.06 0.13 0.11 0.10 0.09 0.06 0.12
0.16 0.12 0.03 0.04 0.08 0.00 0.05 0.11 0.07 0.10
NT NT NT NT NT NT NT NT NT NT
NT NT NT NT NT 0.00 NT NT NT NT
NT NT NT NT NT NT NT NT NT NT
NT NT NT NT NT 0.00 NT NT NT NT
1075 923 RNV RNV
1278 1238
989 1350
RNV 1010
1097 1024 1073
RNV RNV 993 RNV 963 1149 RNV
SPEC
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL HEMATOLOGY VALUES FOR FEMALE RATS
Animal
ANPR
ALYM
AMON
AEOS
ABAS
ALUC
ABLT
AMSC
PLT
Number xlOA3/fiL xl0A3//xL xlOA3//L xl0A3//xL xl0A3//xL xlOA3//xL xlOA3/h x 10a 3/m L xlOA3/L
Female, Group: VI - 250 mg/kg - Day 92
641244 641251 641269 641292 641302 641362 641363 641375 641379 641398
NT NT 0.00 NT NT NT NT NT NT NT
10.21 6.82 6.98 7.11 8.65 6.46 9.07
11.53 5.79
10.83
0.39 0.21 0.37 0.15 0.12 0.25 0.30 0.23 0.13 0.32
Female, Group: VIII - 1000 mg/kg - Day 92
641237 641275 641279 641299 641300 641314 641326 641327 641380 641390
o.oo' NT NT NT NT NT NT NT NT
.NT
5.24 6.30 8.42 8.61 14.50 9.55 9.93 7.79 5.65 8.38
0.25 0.12 0.21 0.17 0.19 0.31 0.35 0.22 0.08 0.24
0.14 0.10 0.12 0.18 0.10 0.13 0.17 0.12 0.08 0.20
0.12 0.15 0.19 0.12 0.11 0.17 0.13 0.07 0.06 0.16
0.06 0.25 0.00 0.08 0.14 0.05 0.08 0.19 0.09 0.06
0.00 0.09 0.06 0.14 0.18 0.09 0.09 0.06 0.06 0.07
0.11 0.23 0.00 0.07 0.17 0.10 0.11 0.31 0.07 0.12
0.00 0.09 0.06 0.39 0.28 0.10 0.12 0.05 0.11 0.08
NT NT 0.00 NT NT NT NT NT NT NT
0.00 NT NT NT NT NT NT NT NT NT
NT NT 0.00 NT NT NT NT NT NT NT
0.00 NT NT NT NT NT NT NT NT NT
850 1118
RNV 1071 1005 1058
999 1177
937 1168
RNV 1194
866 1017
927 1054 1132 1286 1136
837
SPEC
m o M S I UI8IU03IOU S S O Q -pazijjUBg Aued|s|03
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________________
DuPont-4739
INDIVIDUAL HEMATOLOGY VALUES FOR FEMALE RATS
Animal Number
COND
RBC
xlO *6/fiL
HGB g/dL
Female, Group: II - 0 mg /kg - Day 124
641253 641266 641281 641294 641325 641331 641359 641364 641383 641400
OK 8 .43 15.1 OK 8 .16 14.8 OK 8 .07 14.8 OK 7 .93 15.0
OK 8 .11 14.9
OK 8 .50 15.5 OK 7 .77 15.3 OK 8 .79 15.4 OK 7 .59 14.3 OK 7 .85 15.2
Female/ Group: VIII - 1000 mg/kg - Day 124
641234 641256 641282 641352 641356 641366 641377 641385 641387 641399
OK' OK OK OK NSR OK OK OK OK OK
7..83 7,,67 7.,96 8.,66
NT 8. 79' 8. 54 7, 50 8. 18 7. 86
14.4 14.8 15.8 16.0
NT 15.8 15.4 14.1 15.0 14.3
HCT %
46.5 45.6 44.2 46.8 45.1 46.946.1 47.1 43.3 46.6
43.8 44.5 49.1 49.0
NT 48.3 47.4 42.7 45.5 44.1
MCV fL
55.2 55.9 54.8 59.0 55.7 55.2 59.3 53.6 57.1 59.3
56.0 58.0 61.6 56.7
NT 55.0 55.5 57.0 55.6 56.1
MCH
pg
17.9 18.2 18.4 18.9 18.3 18.2 19.7 17.5 18.9 19.4
18.4 19.2 19.8 18.5
NT 18.0 18.0 18.8 18.4 18.2
MCHC g/dL
RDW ARET
WBC ANEU
% xI O ^ / m L x I O ^ / m L x IO'-S/m L
32.5 32.5' 33.5 32.0 32.9 33.0 33.2 32.7 33.1 32.7
12.2 12.6 11.5 11.5 12.2 12.6 11.9 11.4 12.2 11.4
32.8 33.2 32.1 32.7
NT 32.7 32.4 32.9
33.0 32.4
11.8 11.4 12.2 11.7
NT 12.4 11.9 12.0 11.7 11.6
195. 202. 157. 185. 166. 157. 157. 180. 155. 202.
15.19 9.55 9.96
10.19 7.10
16.07 10.83 11.36 10.81
9.93
123. 156. 229. 164. NT 186. 186. 151. 170. 140.
8.08 8.12 13.05 10.70
NT 11.78
9.71 13.54 14.43
8.08
0 .98 o .84 0 .94 0 .93 1 .00 1 .61 o .75 1 .11 0 .86 0 .99
0,.80 0,.58 0..91 1.,04
NT 1. 96 1. 35 1. 21 1. 36 0. 77
673
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
.Company Sanitized. Does not contain TSCA Cl
INDIVIDUAL HEMATOLOGY VALUES FOR FEMALE RATS
Animal
ANPR
ALYM
AMON
AEOS
ABAS
ALUC
ABLT
AMSC
PLT
Number x I O ^ / m L X103/ML xlOA3/fih xl0*3/h X1CT3/ML xio^z/h xl0*3/fiL xlOA3/iiL x 10a 3/m L
Female, Group: II - 0 mg/kg - Day 124
641253 641266 641281 641294 641325 641331 641359 641364 641383 641400
NT NT NT NT NT 0.00 NT NT NT NT
13.25 8.08 8.33 8.24 5.27
13.66 9.66 9.40 9.32 8.28
0.40 0.23 0.27 0.41 0.32 0.32 0.20 0.40 0.31 0.21
Female, Group: VIII - 1000 mg/kg - Day 124
641234 641256 641282 641352 641356 641366 641377 641385 641387 641399
NT" NT 0.00 NT NT NT NT NT NT NT
6.61 6.98 11.48 9.13
NT 8.86 7.86 11.68 12.17 6.61
0.20 0.24 0.52 0.22
NT 0.51 0.17 0.33 0.33 0.29
0.18 0.11 0.19 0.09 0.15 0.48 0.07 0.21 0.08 0.08
0.13 0.06 0.13 0.12
NT 0.13 0.14 0.09 0.13 0.16
0.17 0.05 0.12 0.15 0.09 0.00 0.05 0.06 0.07 0.15
0.21 0.12 0.00 0.10
NT 0.16 0.06 0.04 0.05 0.06
0.20 0.25 0.10 0.36 0.27 0.00 0.11 0.18 0.17 0.22
0.14 0.14 0.00 0.09
NT 0.18 0.12 0.19 0.38 0.19
NT NT NT NT NT 0.00 NT NT NT NT
NT NT 0.00 NT NT NT NT NT NT NT
NT NT NT NT NT 0.00 NT NT NT NT
NT NT 0.00 NT NT NT NT NT NT NT
787 RNV RNV 947 1007 757 1096 RNV 1112 971
957 1168 1089 1033
NT 1041
794 934 898 948
SPEC
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________
DuPont-4739
INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR MALE RATS
Animal
NORM
ANIS
MIC
MAC POLY HYPO ECHI ACAN TARG
Number
RX HJB
Male, Group: I - 0 mg/kg - Day 44
641069 641070 641094 641147 641149 641155 641172 641206 641214 641222
Male, Group: III - 50 mg/kg - Day 44
641055 641056 m 641073 641081 641144 641146 641178 641198 641218 641224
1 3- 1 1 21 1 42 1 31 1 41 1 31 11 1 32 1 42
1 42 1 42 1 31 1 31 1 21 1 31 1 32 1 22 1 42 1 32
fiat contain TSCA CEI
675
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________
DuPont-4739
INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR MALE RATS
Animal
NORM
ANIS
MIC
MAC POLY HYPO ECHI ACAN TARG
Number
RX HJB
Male, Group: V - 250 mg/kg - Day 44
641061 641089 641102 641134 641137 641162 641190 641197 641200 641202
Male, Group: VII - 1000 mg/kg - Day 44
o 641067 O 641077 </ 641086 3 641095 O 641097
641132 641157 641166 641201 641223
1 1 22 1 22 1 33 1 21 1 21 1 32 1 42 1 42 1 21
1 21 1 23 1 31 1 33 1 32 1 33 11 1 2 1 1 22 1 43
s ^ t a 'n TSCACB!
676
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR MALE RATS
Animal Number
SPEC
Male, Group: I - 0 mg/kg - Day 44
641069 641070 641094 641147 641149 641155 641172 641206 641214 641222
4-HEMOGLOBIN CRYSTAL
4-HEMOGLOBIN CRYSTAL 4-HEMOGLOBIN CRYSTAL 4-HEMOGLOBIN CRYSTAL; 1-SPHEROCYTE
Male, Group: III - 50 mg/kg - Day 44
641055 641056 641073
641081 641144 641146
641178 641198 641218 641224
4-HEMOGLOBIN CRYSTAL 4-HEMOGLOBIN CRYSTAL
DuPont-4739
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR MALE RATS
Animal Number
SPEC
Male, Group: V - 250 mg/kg - Day 44
641061 641089 641102 641134 641137 641162 641190 641197 641200 641202
4-HEMOGLOBIN CRYSTAL 2-HEMOGLOBIN CRYSTAL
4-HEMOGLOBIN CRYSTAL
Male, Group: VII - 1000 mg/kg - Day 44
641067 641077 641086 641095 641097 641132 641157 641166 641201 641223
1-SPHEROCYTE 4-HEMOGLOBIN CRYSTAL 1-SPHEROCYTE
4-HEMOGLOBIN CRYSTAL 1-SPHEROCYTE
DuPont-4739
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________________________________________________DuPont-4739
INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR MALE RATS
Animal Number
NORM
ANIS
MIC
Male, Group: I - 0 mg/kg - Day 91
641069 641070 641094 641147 641149 641155 641172 641206 641214 641222
Male, Group: III - 50 mg/kg - Day 91
641055 641056 641073 641081 641144 641146 641178 641198 641218 641224
' --
1
1
MAC POLY HYPO ECHI ACAN TARG
1 21 11 11 1 11 1 11 1 21 1 11 11 1 11 1 21
11 1 11 11 1 11 1 11 1 21 11 11 1 22 1 11
RX HUB
Sanitised, Does not contain TSC CBI
679
f 'N
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________________
INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR MALE RATS
Animal Number
NORM
ANIS
MIC
Male, Group: V - 250 mg/kg - Day 91
641061 641089 641102 641134 641137 641162 641190 641197 641200 641202
Male, Group: VII - 1000 mg/kg - Day 91
641067 641077 641086 641095 641097 641132 641157 641166 641201 641223
MAC POLY HYPO ECHI ACAN
1 1 1- 2 1 22 1 11 1 11 11 1 22 1 11 1 11 1
1 1 21 11 1 21 11 1 11 1 1 11 1 11
TARG
fB Il DuPont-4739
RX HJB
Does not contain TSC CBf
680
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR MALE RATS
Animal Number
SPEC
Male, Group: 1 - 0 mg/kg - Day 91
641069 641070 641094 641147 641149 641155 641172 641206 641214 641222
1-SPHEROCYTE 1-SPHEROCYTE
Male, Group: III - 50 mg/kg - Day
641055
641056
641073
641081
1-SPHEROCYTE
3 641144
641146
641178
1 -SPHEROCYTE
641198
2-SPHEROCYTE
641218
1-SPHEROCYTE
641224
1-SPHEROCYTE
DuPont-4739
tscacb*
681
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR MALE RATS
Animal Number
SPEC
Male, Group: V - 250 mg/kg - Day 91
641061 641089 641102 641134 641137 641162 641190 641197 641200 641202
1-SPHEROCYTE 1-SPHEROCYTE
Male, Group: VII - 1000 mg/kg - Day 91
641067 641077 641086 641095 641097 641132 641157 641166 641201 641223
2-SPHEROCYTE
2-SPHEROCYTE 1-SPHEROCYTE 1-SPHEROCYTE
1-SPHEROCYTE 1-SPHEROCYTE
DuPont-4739
I
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______________
DuPont-4739
INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR MALE RATS
Animal
NORM
ANIS
MIC
MAC POLY HYPO ECHI ACAN TARG
Number
RX HJB
! Male, Group: I - 0 mg/kg - Day 123 641083 641084 641085 641101 641105 641123 641154 641159 641165 641215
Male, Group: VII - 1000 mg/kg - Day 123
1
11 1 11 11 1 21 1 .1 1 11 1 11 11 1 11
641064 641092 641143 641153 641167 641185 641189 641203 641213 641216
1
1 11 1 11 1 11 1 11 1
1 11 1 21 1
1 21
@es not contain TSCA CBf
683
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________________________________________________DuPont-4739
INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR MALE RATS
Animal Number
SPEC
esPF SanHke Does notcontain TSCA CI
Male, Group: I - 0 mg/kg - Day 123
641083 641084 641085 641101 641105 641123 641154 641159 641165 641215
Male, Group: VII - 1000 mg/kg - Day 123
641064 641092 641143 641153 641167 641185 641189 641203 B 641213 ~ 641216
684
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR FEMALE RATS
Animal Number
NORM
ANIS
MIC
Female, Group: II - 0 mg/kg - Day 44
641240 641245 641249 641257 641283 641290 641293 641335 641344 641384
Female, Group: IV - 50 mg/kg - Day 44
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
MAC POLY HYPO ECHI ACAN
1 41 1 41 1 41 1 41 12 1 42 1 31 1 42 1 31 1 41
1 42 1 42 1 41 1 41 1 31 1 41 1 31 1 42 1 41 1 41
TARG
DuPont-4739
RX HJB
685
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR FEMALE RATS
Animal Number
NORM
ANIS
MIC
Female, Group: VI - 250 mg/kg - Day 44
641244 641251 641269 641292
641302 641362 641363 641375 641379 641398
Female, Group: VIII 1000 mg/kg - Day 44
641237 641275 641279 641299 641300 641314 641326 641327 641380 641390
.-
MAC POLY HYPO ECHI ACAN TARG
1 41 1 4- 2 1 31 1 41 1 31 1 31 1 32 1 41 1 41 1 41
1 31 1 31 1 31 1 31 1 41 1 41 1 31 1 41 1 41 1 41
I DuPont-4739
RX HJB
0oes contain TSCA CBI
686
J
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR FEMALE RATS
Animal Number
SPEC
Female, Group: II - 0 mg/kg - Day 44
641240
I 641245 641249 641257 641283 641290 641293 641335 641344 641384
Female, Group: IV - 50 mg/kg - Day 44
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
4-HEMOGLOBIN CRYSTAL 4-HEMOGLOBIN CRYSTAL
DuPont-4739
Does not osniain TSCACBS
687
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR FEMALE RATS
Animal Number
SPEC
Female, Group: VI - 250 mg/kg - Day 44
641244 641251 641269 641292 641302 641362 641363 641375 641379 641398
4-HEMOGLOBIN CRYSTAL
Female, Group: VIII - 1000 mg/kg - Day 44
641237 641275 641279 641299 641300 641314 641326 641327 641380 641390
4-HEMOGLOBIN CRYSTAL 4-HEMOGLOBIN CRYSTAL
4-HEMOGLOBIN CRYSTAL 4-HEMOGLOBIN CRYSTAL
DuPont-4739
J
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____
INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR FEMALE RATS
Animal Number
NORM
ANIS
MIC
Female, Group: II - 0 mg/kg - Day 92
641240 641245 641249 641257 641283 641290 641293 641335 641344 641384
Female, Group: IV - 50 mg/kg - Day 92
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
MAC POLY HYPO ECHI ACAN TARG
DuPont-4739
RX HJB
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR FEMALE RATS
Animal
NORM
ANIS
MIC
MAC POLY HYPO ECHI ACAN TARG
Number
RX HJB
Female, Group: VI - 250 mg/kg - Day 92
641244 641251 641269 641292 641302 641362 641363 641375 641379 641398
Female, Group: VIII 1000 mg/kg - Day 92
8 641237 641275 641279 641299 641300 641314 641326 641327 641380 641390
13 11 1 21 1 21 1 11 11 1 21 1 1 21 11
1 11 12 11 1 1 21 1 21 1 21 1 21 11
not contain TSCACBI
690
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR FEMALE RATS
Animal Number
SPEC
Female, Group: II - 0 mg/kg - Day 92
641240 641245 641249 641257 641283 641290 641293 641335 641344 641384
Female, Group: IV - 50 mg/kg - Day 92
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
1-SPHEROCYTE
DuPont-4739
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR FEMALE RATS
Animal Number
SPEC
Female, Group: VI - 250 mg/kg - Day 92
641244 641251 641269 641292 641302 641362 641363 641375 641379 641398
1-SPHEROCYTE
Female, Group: VIII - 1000 mg/kg - Day 92
641237 641275 641279 641299 641300 641314 641326 641327 641380 641390
1-SPHEROCYTE
DuPont-4739
CfflpasSanitized ros not contain TSCA ck
I
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR FEMALE RATS
Animal Number
NORM
ANIS
MIC
Female, Group: II -
641253 641266 641281 641294 641325 641331 641359 641364 641383 641400
mg/kg - Day 124
Female, Group: vili
641234 641256 641282 641352 641356 641366 641377 641385 641387 641399
1000 mg/kg - Day 124
MAC POLY HYPO ECHI ACAN
1 22 11 1 11 11 1 11 1 1 21 1 21 11 1
1 31 11 11 1 31
1 11 1 31 1 2 1 1 32 11
TARG
DuPont-4739
RX HJB
693
CompanySanitized. Does notcontai TSC CBI
,w-'
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR FEMALE RATS
Animal Number
SPEC
Female, Group: II - 0 mg/kg - Day 124
641253 641266 641281 641294 641325 641331 641359 641364 641383 641400
Female, Group: VIII - 1000 mg/kg - Day 124
641234 641256 641282 641352 641256 641366 641377 641385 641387 641399
DuPont-4739
694
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL WHITE BLOOD CELL / PLATELET MORPHOLOGY VALUES FOR MALE RATS
Animal
NORM
SM
DB
PC
GP
BP TOX
VC SPEC
Number
Male, Group: I - 0 mg/kg - Day 44
641069 641070 641094 641147 641149 641155 641172 641206 641214 641222
NORMAL
NORMAL NORMAL NORMAL NORMAL
Male, Group: III - 50 mg/kg - Day 44
641055
641056
641073
641081
NORMAL
641144
641146
NORMAL
641178
NORMAL
641198
NORMAL
641218
NORMAL
641224
5 J
1 1 1 1
1 1 1
1
ADEQ PLATELETS ADEQ PLATELETS DECR PLATELETS DECR PLATELETS
ADEQ PLATELETS DECR PLATELETS ADEQ PLATELETS
ADEQ PLATELETS
Sanitized. Does not contain TSCfi
695
CmPa"
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL WHITE BLOOD CELL / PLATELET MORPHOLOGY VALUES FOR MALE RATS
Animal
NORM
SM DB
PC
GP
BP TOX
VC SPEC
Number
Male, Group: V - 250 mg/kg - Day 44
641061 641089 641102 641134 641137 641162 641190 641197 641200 641202
NORMA_L_
NORMAL NORMAL NORMAL NORMAL NORMAL
NORMAL
__ __ __ __ __ __ ____ __
--
Male, Group: VII - 1000 mg/kg - Day 44
__ __ __ __ __ __ __ __
--
641067 641077 641086 641095 641097 641132 641157 641166 641201 641223
NORMA_L_
NORMAL NORMAL NORMAL
NORMA__L
NORMAL NORMAL NORMAL
__ __ __ __ __ __ __ --
__ __
1 1
--
1
__
1 1
ADEQ PLATELETS DECR PLATELETS
DECR PLATELETS
t .Mah SCA CM
696
jf ' J
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________
jj
DuPont-4739
INDIVIDUAL WHITE BLOOD CELL / PLATELET MORPHOLOGY VALUES FOR MALE RATS
Animal
NORM
SM
DB
PC
GP
Number
Male, Group: I - 0 mg/kg - Day 91
641069 641070 641094 641147 641149 641155
NORMAL NORMAL NORMAL NORMAL NORMAL
--
_
-__ __ __ __
_
__
__ __ __ __
__ ____ __
1
__
---
641172
__ _
1
641206 641214
NORMAL
__
__
_
__
1
641222 -- -- -- --
1
Male, Group: III - 50 mg/kg - Day 91
641055 641056 641073 641081
NORMAL-
NORMAL
NORMAL
--
__
__ __ __
__
__
1
641144 641146
-- NORMAL
--
__ _...
i
641178 -- _ _ _
1
641198 641218
NORMAL
--
__
__
_
__
i
641224
NORMAL
--
__
TOX VC SPEC
ADEQ PLATELETS ADEQ PLATELETS
ADEQ PLATELETS ADEQ PLATELETS ADEQ PLATELETS
Boes not contain TSCA CBI
697
J
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL WHITE BLOOD CELL / PLATELET MORPHOLOGY VALUES FOR MALE RATS
Animal
NORM
SM
DB
PC
GP
BP TOX
VC SPEC
Number
Male, Group: V - 250 mg/kg - Day 91
641061 -- __ --
1
_ __ __ DECR PLATELETS
641089 641102 641134
NORMAL NORMAL
--
--- --
-- ---
---
__ 1
-__ --
__
__ __
641137
NORMAL
--
--
641162 -- --
--
641190
NORMAL
--
--
641197
NORMAL
--
--
641200
NORMAL
__
--
__ -__ -- _
__ 1
__
__
__ _
_
__
__ __ __
__
__ ____ __
641202
NORMAL
--
--
--
--
--
-- --
Male, Group: VII - 1000 mg/kg - Day 91
641067 641077 641086 641095 641097 641132 641157 641166 641201 641223
NORMALNORMAL NORMAL
---
NORMAL NORMAL NORMAL NORMAL NORMAL
__ __
__
__ __ __
--
__ _ __
__
_
____ __
____ ___
1
__1
____
__
__
__
__ __
__ __
__
__ __
DECR PLATELETS ADEQ PLATELETS
__
Doenotcontain TSCACBI
698
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL WHITE BLOOD CELL / PLATELET MORPHOLOGY VALUES FOR MALE RATS
A nim al
NORM
SM DB
PC
GP
BP TOX
VC SPEC
Number
Male, Group: I - 0 mg/kg - Day 123
641083 641084 641085 641101 641105 641123 641154 641159 641165 641215
NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL
NORMAL
Male, Group: VII - 1000 mg/kg - Day 123
641064 641092 641143 641153 641167 641185 641189 641203 641213 641216
NORMAL NORMAL NORMAL
NORMAL NORMAL
NORMAL NORMAL
1 1 1
1
1 1
ADEQ PLATELETS DECR PLATELETS ADEQ PLATELETS
DECR PLATELETS
oes no*contain TSCA CB
699
.Company Sanitized. Does not contain T S C A C8I
H-24616: Subchronic Toxicity _90-DayC}avage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL WHITE BLOOD CELL / PLATELET MORPHOLOGY VALUES FOR FEMALE RATS
Animal
NORM
SM
DB
PC
GP
BP TOX
VC SPEC
Number
Female, Group : II - 0 mg/kg -- Day 44
641240 641245 641249 641257 641283 641290 641293 641335 641344 641384
NORMAL
--
NORMAL
--
NORMAL
--
NORMAL
--
NORMAL --
__
______ __ _____ -__ ----
--
Female, Group : IV - 50 mg/kg - Day 44
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
______
NORMAL
__
NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL
-- -- --
-- __ ----
__ __ __ __ __
__ _____
--
__
----
--
--
--
-__ --
1 1 1 1 1
1 1
DECR PLATELETS ADEQ PLATELETS ADEQ PLATELETS ADEQ PLATELETS DECR PLATELETS
ADEQ PLATELETS ADEQ PLATELETS
700
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL WHITE BLOOD CELL / PLATELET MORPHOLOGY VALUES FOR FEMALE RATS
Animal
NORM
SM
DB
PC
GP
BP TOX
VC SPEC
Number
Female, Group: VI - 250 mg/kg - Day 44
641244 641251 641269 641292 641302 641362 641363 641375 641379 641398
NORMAL NORMAL NORMAL
NORMAL
__
--
NORMAL --
__ __ ____ ____ __ __
--
__
__ __
__ ____
__ __
--
1
i l i
l
Female, Group : VIII - 1000 mg/kg - Day 44
641237 641275 641279 641299 641300 641314 641326 641327
NORMALNORMAL NORMAL NORMAL
--
NORMAL
--
--
__
-- __ -- __ -- __ __
__
__
__ __
__ ____
641380
NORMAL
__
641390
NORMAL
--
__
9
>
o m
l
l l
DECR PLATELETS DECR PLATELETS DECR PLATELETS ADEQ PLATELETS
DECR PLATELETS DECR PLATELETS DECR PLATELETS
701
Company Sanitized. Does notcontain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL WHITE BLOOD CELL / PLATELET MORPHOLOGY VALUES FOR FEMALE RATS
Animal Number
NORM
SM DB
pc
GP
BP TOX
VC SPEC
Female, Group: II - 0 mg/kg - Day 92
641240 641245 641249 641257 641283 641290 641293 641335 641344 641384
NORMAL
__
__
__
NORMAL NORMAL NORMAL
NORMA__L
NORMAL
__
__
__ __ __ __ __ __ __
--
Female, Group : IV - 50 mg/kg - Day 92
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
NORMAL NORMAL NORMAL
--
--
NORMAL
--
NORMAL NORMAL
--
__
____
__
__ __
--
--
__ __ _- _-- __ __ __
__ --
1
\
1 1 1
__
1
ADEQ PLATELETS ADEQ PLATELETS
ADEQ PLATELETS
DECR PLATELETS DECR PLATELETS ADEQ PLATELETS ADEQ PLATELETS
702
J
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL WHITE BLOOD CELL / PLATELET MORPHOLOGY VALUES FOR FEMALE RATS
Animal
NORM
SM
DB
Number
Female, Group: VI - 250 mg/kg - Day 92
641244 641251 641269 641292 641302 641362 641363 641375 641379 641398
NORMAL NORMAL
--
--
NORMAL NORMAL NORMAL
--
NORMAL NORMAL
__
__ __ __ __ __ __ _____
__
_
______
__ _
Female, Group : VIII - 1000 mg/kg - Day 92
641237
__
641275
NORMAL
__
641279
--
--
641299 641300
NORMAL NORMAL
__
__
______
641314
NORMAL
__
641326
NORMAL
--
__
641327
NORMAL
--
--
641380
NORMAL
__
641390
NORMAL
--
--
PC GP
__ __ __ 1 __
1
_______ __ _____
1_____
1
_____
_____
__ _ 1 _______ _______ __ ______
_____ _____ __ __
BP TOX
__ __
_____ _____
__ _ _ __ __ __ __ ____ _____ __ _ _
-- "
__
_ _ __ _
__
_____
_______ __ __ __
VC SPEC
__ __ __ DECR PLATELETS
-- DECR PLATELETS
_____ __ _
-CooepMfSanitized. Does not contain TSCACBI
703
J
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL WHITE BLOOD CELL / PLATELET MORPHOLOGY VALUES FOR FEMALE RATS
Animal Number
NORM
SM
DB
PC
GP
BP TOX
VC SPEC
Female, Group: II - 0 mg/kg - Day 124
641253 641266 641281 641294 641325 641331 641359 641364 641383 641400
NORMA__L __ __
NORMAL NORMAL NORMAL
__
NORMAL
__ ___ _,, _ __ _ __ _
--
__ __ ~
Female, Group : VIII - 1000 mg/kg - Day 124
641234 641256 641282 641352 641356 641366
____ __ NORMA_L_
NORMAL
_ __ _ _ .1
641377 641385
NORMAL NORMAL
__
641387 641399
NORMA- L-
_ __
_
11 1
1
11 1
1 1 1
1
ADEQ PLATELETS ADEQ PLATELETS
ADEQ PLATELETS
.CompanySanitized. Does notcontain TSCACBi
704
Skmpang Sanitized. Does not contain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________________________________________________DuPont-4739
INDIVIDUAL COAGULATION VALUES FOR MALE RATS
Animal Number
PHEM
PLIP
PICT
Male, Group: I - 0 mg/kg - Day 91
641069 641070 641094 641147 641149 641155 641172 641206 641214 641222
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Male, Group: III - 50 mg/kg - Day 91
641055 641056 641073 641081 641144 641146 641178 641198 641218 641224
NONENONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
PT sec
15.1 15.2 14.5 15.3 16.0 15.4 14.9 15.3 14.6 15.0
15.1 14.8 14.4 15.6 15.6 15.0 15.3 15.7 14.8 14.5
APTT sec
19.7 20.6 20.0 16.7 30.1 20.1 16.7 18.8 18.5 19.4
22.0 21.2 18.2 17.1 20.0 27.2 19.3 18.1 17.2 18.3
705
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL COAGULATION VALUES FOR MALE RATS
Animal Number
PHEM
PLIP
PICT
Male, Group: V - 250 mg/kg - Day 91
641061 641089 641102 641134 641137 641162 641190 641197 641200 641202
NONE NONE NONE NONE NONE NONE CLOT NONE NONE NONE
NONE NONE NONE NONE NONE NONE
NT NONE NONE NONE
NONE NONE NONE NONE NONE NONE
NT NONE NONE NONE
Male, Group: VII - 1000 mg/kg - Day 91
641067 641077 641086 641095 641097 641132 641157 641166 641201 641223
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
PT sec
16.2 15.9 15.3 14.9 16.9 15.5
NT 16.6 15.4 15.0
15.7 15.5 16.0 14.8 15.0 15.7 15.9 16.9 16.1 15.2
APTT sec
21.0 17.4 19.5 20.5 17.9 19.3
NT 22.9 21.0 19.1
15.3 18.2 20.7 22.6 16.8 16.5
2200.. 24
21.7 22.3
DuPont-4739
<J.
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL COAGULATION VALUES FOR FEMALE RATS
Animal Number
PHEM
PLIP
PICT
Female, Group: II - 0 mg/kg - Day !92
641240 641245 641249 641257 641283 641290 641293 641335 641344 641384
NONE NONE
NSR NONE NONE NONE NONE NONE NONE NONE
NONE NONE
NT NONE NONE NONE NONE NONE NONE NONE
NONE NONE
NT NONE NONE NONE NONE NONE NONE NONE
Female, Group: IV - 50 mg/kg - Day 92
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
PT sec
15.1 15.2
NT 15.5 15.2 14.9 15.8 15.1 15.9 15.2
14.8 15.3 14.7 15.6 16.3 15.6 14.9 13.9 15.9 15.0
APTT sec
18.6 19.2
NT 18.4 19.0 19.6 20.7 22.0 20.3 20.7
17.4 18.2 23.1 21.8 19.2 17.7 20.7 18.9 20.4 18.2
1_ DuPont-4739
Does notcor!* ^^A CBI
707
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL COAGULATION VALUES FOR FEMALE RATS
Animal Number
PHEM
PLIP
PICT
Female, Group: VI - 250 mg/kg - Day 92
641244 641251 641269 641292 641302 641362 641363 641375 641379 641398
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Female, Group: VIII - 1000 mg/kg - Day 92
641237 641275 641279 641299 641300 641314 641326 641327 641380 641390
NONE. NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
PT sec
15.4 16.0 15.3 15.3 16.3 15.2 13.9 14.5 14.3 15.6
15.4 15.3 14.8 15.8 15.6 15.1 15.1 14.3 15.9 14.6
APTT sec
17.3 16.9 18.2 19.5 17.4 19.5 20.3 17.4 17.9 18.4
20.2 16.4 16.7 19.2 17.8 16.8 20.2 17.6 18.3 20.0
DuPont-4739
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS
Animal Number
SHEM
SLIP
SICT
Male, Group: I - 0 mg/kg - Day 44
641069 641070 641094 641147 641149 641155 641172 641206 641214 641222
TRACE TRACE SMALL
NONE NONE TRACE TRACE SMALL SMALL NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Male, Group: III - 50 mg/kg - Day 44
641055 641056 641073 641081 641144 641146 641178 641198 641218 641224
NONE SMALL SMALL
NONE SMALL SMALL
NONE NONE SMALL NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
AST IU/L
105 81 91 67 87
114 85 75
119 81
72 88 88 65 86 71 79 99 132 83
ALT IU/L
SDH IU/L
33 18.6 48 19.9 40 16.2 24 17.8 37 20.0 39 23.3 39 19.4 35 20.2 43 19.9 39 29.0
36 23.6 51 26.5 34 21.3 30 16.9 41 25.7 29 22.0 37 20.1 .44 28.1 47 18.5 36 39.4
ALKP IU/L
BILI mg/dL
BUN mg/dL
CREA mg/dL
CH0L mg/dL
112 0.16 103 <0.10 152 <0.10 122 <0.10 125 0.11 138 <0.10 156 0.11 127 0.11 115 <0.10 121 0.14
99 0.11 121 <0.10 168 <0.10 111 <0.10 141 <0.10 143 <0.10 116 0.11 159 <0.10 102 0.12 136 <0.10
17 0.36 14 0.36 15 0.33 12 0.35 15 0.40 17 0.40 15 0.35 18 0.37 14 0.38 14 0.40
12 0.41 15 0.38 19 0.42 15 0.32 16 0.40 13 0.30 14 0.26 14 0.39 15 0.37 14 0.32
104 58 67 88 52 78 90 68 62 82
66 62 71 59 66 50 80 44 82 74
Company Sanitized. Does not contain TSCA cal
709
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS
Animal Number
SHEM
SLIP
SICT
Male, Group: V - 250 mg/kg - Day 44
641061 641089 641102 641134 641137 641162 641190 641197 641200 641202
NONE SMALL TRACE TRACE
NONE TRACE SMALL TRACE
NONE TRACE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Male, Group: VII - 1000 mg/kg - Day 44
641067 641077 641086 641095 641097 641132 641157 641166 641201 641223
SMALL. TRACE SMALL SMALL TRACE SMALL SMALL
NONE SMALL
NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE . NONE NONE NONE NONE NONE NONE NONE NONE
AST IU/L
72 77 65 81 87 81 89 108 106 84
104 91 88 78 77 80 84
110 90 81
ALT IU/L
32 33 35 39 55 34 33 36 38 30
53 42 42 41 35 35 37 68 37 45
SDH IU/L
24.6 23.4 14.1 24.8 25.2 24.0 26.4 29.4 29.3 16.1
19.8 19.1 20.4 22.3 21.0 23.1 13.6 28.0 18.6 19.4
ALKP IU/L
BILI mg/dL
BUN mg/dL
CREA mg/dL
CHOL mg/dL
94 <0.10 119 <0.10 119 <0.10 142 0.10 106 <0.10
92 <0.10 153 <0.10 112 <0.10 102 0.11 110 <0.10
156 0.10 115 0.11 146 <0.10 138 <0.10 131 <0.10 206 <0.10 142 <0.10 209 <0.10 160 <0.10 180 <0.10
19 0.28 15 0.24 11 0.27 17 0.35 19 0.35 17 0.31 14 0.37 14 0.34 13 0.43 15 0.35
19 0.41 14 0.33 14 0.38 16 0.37 15 0.26 17 0.36 18 0.25 15 0.31 18 0.43 14 0.30
47 40 61 50 69 43 50 47 77 62
51 40 36 48 46 81 33 42 45 45
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS
Animal Number
TRIG mg/dL
GLUC mg/dL
TP
g/dL
Male, Group: I - 0 mg/kg - Day 44
641069 105 105
641070 116 105
641094
67 113
641147 38 97
641149
72 101
641155
51 101
641172
94 114
641206
41 108
641214 59 93
641222 105 101
Male, Group: III - 50 mg/kg - Day 44
641055 641056 641073 641081 641144 641146 641178 641198 641218 641224
85' 81 101 34 140 36 84 99 42 184
107
109
99 103
114
io i
94 102
101 106
6.8 7.0 6.5 6.5 6.4 6.7 7.0 6.8 6.5 7.1
6.8 6.7 6.6 6.6 6.9 6.8 6.7 7.1 6.8 6.6
ALB g/dL
4.3 4.3 4.4 4.1 4.1 4.1 4.2 4.2 4.2 4.4
4.2 4.1 4.4 4.1 4.4 4.2 4.1 4.4 4.4 4.3
GLOB g/dL
CALC mg/dL
IPHS mg/dL
NA mmol/L
K mmol/L
CL mmol/L
2.5 10.6 2.7 11.2 2.1 10.3 2.4 10.3 2.3 10.8 2.6 10.8 2.8 10.9 2.6 10.4 2.3 10.7 2.7 11.1
2.6 10.7 2.6 10.3 2.2 11.0 2.5 11.0 2.5 10.7 2.6 10.8 2.6 10.8 2.7 11.3 2.4 10.4 2.3 11.1
8.7 144.3 8.8 149.1 8.1 147.9 8.1 147.7 9.1 149.9 8.6 147.7 7.9 147.1 7.9 149.8 9.2 148.4 9.6 147.9
9.3 147.6 9.0 148.1 9.1 148.8 7.8 148.1 8.4 148.0 8.7 149.0 8.7 147.8 9.5 149.6 8.6 146.4 8.1 147.2
6.71 7.10 6.31 6.14 6.14 6.21 6.01 6.55 6.86 6.50
98.8 99.5 100.7 100.0 100.0 97.8 99.7 99.8 99.3 97.1
6.39 6.13 6.57 6.29 6.41 6.06 6.16 6.48 6.08 6.31
99.0 97.1 96.7 98.6 97.9 97.4 99.4 98.3 98.9 98.1
PHEM
NT NT NT NT NT NT NT NT NT NT
NT NT NT NT NT NT NT NT NT NT
Does not coniato TSC CB!
711
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS
Animal Number
TRIG mg/dL
GLUC mg/dL
TP g/dL
Male, Group: V - 250 mg/kg - Day 44
641061 72 98
641089
38 103
641102
40 109
641134 29 99
641137
61 104
641162 46 97
641190 43 94
641197 27 88
641200 168 107
641202 49 96
Male, Group: VII - 1000 mg/kg -
641067 641077 641086 641095 641097 641132 641157 641166 641201 641223
29- 104 14 101 40 106 55 103 96 127 43 122 25 107 39 96 30 105 44 116
6.9 5.8 6.7 6.3 6.3 6.3 6.3 6.1 6.8 6.3
6.6 7.1 6.7 7.1 6.6 7.1 6.3 7.0 6.4 6.6
ALB g/dL
4.3 3.8 4.4 4.4 4.2 4.4 3.9 4.2 4.4 4.3
4.4 4.7 4.5 4.9 4.5 4.8 4.3 4.8 4.2 4.6
GLOB g/dL
CALC mg/dL
IPHS mg/dL
NA mmol/L
K mmol/L
CL mmol/L
2.6 2.0 2.3 1.9 2.1 1.9 2.4 1.9 2.4 2.0
2.2 2.4 2.2 2.2 2.1 2.3 2.0 2.2 2.2 2.0
11.4 10.4 10.5 10.8 10.4 11.1 10.9 10.2 11.1 10.5
10.6 10.8 10.5 10.7 10.8 11.2 10.6 11.0 10.5 10.6
9.1 9.3 7.9 9.0 7.8 10.0 9.3 9.0 8.7 9.0
148.9 147.8 148.2 148.4 147.3 149.6 148.7 149.3 148.3 148.6
9.7 8.6 9.1 8.9 9.8 10.0 9.0 8.6 8.9 8.7
147.6 147.3 148.1 146.8 148.9 147.8 147.2 148.6 147.2 148.2
6.63 6.48 6.14 6.44 5.86 6.37 6.16 6.35 6.55 6.16
98.0 100.9
99.9 98.8 98.5 98.1 98.2 98.9 97.8 99.8
6.91 6.10 6.42 6.17 7.24 6.86 5.99 6.63 6.14 6.93
97.2 97.7 100.0 96.8 102.2 100.6 102.1 100.8 99.4 100.5
PHEM
Does not eontaln TSCACB?
712
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS
A nim al Number
PLIP
PICT
PFLU
Male, Group:
641069 641070 641094 641147 641149 641155 641172 641206 641214 641222
Male, Group:
641055 641056 641073 641081 641144 641146 641178 641198 641218 641224
0 mg/kg - Day 44
NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT
- 50 mg/kg - Day 44
NT- NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT
NT NT NT NT NT NT NT NT NT NT
NT NT NT NT NT NT NT NT NT NT
DuPont-4739
tm sim g ffk@dL Boes noi emfaln tsc CBS
713
fkimpany Sanfifzed, Does not cw itfn "w a r.m
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS
Animal Number
PLIP
PICT
PFLU
Male, Group: V - 250 mg/kg - Day 44
641061 NT NT NT
641089 NT NT NT 641102 NT NT NT 641134 NT NT NT 641137 NT NT NT 641162 NT NT NT 641190 NT NT NT 641197 NT NT NT 641200 NT NT NT 641202 NT NT NT
Male, Group: VII - 1000 mg/kg - Day 44
641067 NT NT NT
641077 NT NT NT
641086 NT NT NT
641095 NT NT NT
641097 NT NT NT
641132 NT NT NT
641157 NT NT NT
641166 NT NT NT
641201 NT NT NT
641223
NT
NT
NT
DuPont-4739
714
J
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________________________________________________________ DuPont-4739
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS
Animal Number
SHEM
SLIP
SICT
Male, Group: I - 0 mg/kg - Day 91
641069 641070 641094 641147 641149 641155 641172 641206 641214 641222
NONE TRACE
NONE NONE NONE NONE TRACE TRACE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Male, Group: III - 50 mg/kg - Day 91
641055 641056 641073 641081 641144 641146 641178 641198 641218 641224
NONE TRACE TRACE
NONE TRACE
NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE . NONE NONE NONE NONE NONE NONE NONE NONE
AST IU/L
94 74 81 66 96 96 83 84 86 84
78 129
84 83 72 78 79 134 93 90
ALT IU/L
37 36 44 23 36 37 37 33 31 38
34 63 30 40 47 30 35 83 52 42
SDH IU/L
31.2 20.0 20.8 20.1 21.8 21.9 22.7 17.6 22.0 35.8
21.6 27.2 26.9 22.2 26.0 20.3 20.7 44.6 21.9 39.9
ALKP IU/L
BILI mg/dL
BUN mg/dL
CREA mg/dL
CH0L mg/dL
70 0.14 60 0.12 109 0.15 73 0.14 79 0.16 87 0.15 83 0.12 89 0.15 72 0.14 78 0.15
77 <0.10 82 0.15 123 0.11 149 0.14 90 0.12 109 0.12 101 0.15 106 0.20 69 0.20 94 0.13
15 0.41 16 0.49 14 0.41 16 0.36 13 0.40 17 0.40 16 0.44 15 0.41 13 0.44 16 0.39
14 0.31 17 0.34 16 0.44 18 0.33 17 0.32 14 0.38 19 0.37 14 0.42 16 0.42 15 0.32
112 60 70 88 47 78 89 76 62 92
62 57 72 82 68 44 93 30 75 82
Company Sanitized. Does not contain tsoa ' ' pi
715
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS
Animal Number
SHEM
SLIP
SICT
Male, Group: V - 250 mg/kg - Day 91
641061 641089 641102 641134 641137 641162 641190 641197 641200 641202
NONE NONE NONE NONE NONE NONE TRACE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Male, Group: VII - 1000 mg/kg - Day 91
641067 641077 641086 641095 641097 641132 641157 641166 641201 641223
NONE NONE TRACE TRACE TRACE TRACE TRACE TRACE TRACE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
AST IU/L
91 77 66 150 74 65 112 108 98 73
113 92 88
100 82 84 90
128 91 67
ALT IU/L
32 35 39 115 37 36 73 54 47 35
51 40 55 58 39 47 55 56 37 37
SDH IU/L
23.5 18.0 15.7 41.8 21.3 20.2 24.7 25.1 27.3 22.8
18.6 19.0 20.9 31.8 18.5 24.8 22.1 27.1 21.4 19.3
ALKP IU/L
BILI mg/dL
BUN mg/dL
CREA mg/dL
CHOL mg/dL
93 <0.10 98 <0.10 108 0.13 146 0.17 100 0.14 77 0.16 162 0.12 114 0.14 115 0.10 91 0.13
177 0.11 130 0.14 180 0.10 202 0.11 157 0.12 223 0.14 192 0.15 179 0.10 168 0.10 217 0.13
20 0.43 19 0.40 15 0.38 20 0.41 22 0.39 18 0.41 20 0.46 16 0.44 18 0.43 17 0.45
22 0.44 14 0.34 18 0.41 21 0.45 19 0.41 17 0.32 22 0.42 18 0.36 19 0.48 19 0.36
46 42 61 49 79 53 41 37 66 67
41 45 36 58 47 86 36 42 47 53
Does not contain TSC CQ
716
i
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________________________________________
DuPont-4739
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS
Animal Number
TRIG mg/dL
GLUC mg/dL
TP g/dL
Male, Group: I - 0 mg/kg - Day 91
641069 109 117
641070
93 109
641094 139 120
641147
53 105
641149
52 105
641155
53 109
641172
85 117
641206
95 118
641214
54 118
641222
80 110
Male, Group: III - 50 mg/kg - Day 91
641055 641056 641073 641081 641144 641146 641178 641198 641218 641224
77. 92 84 164 174 82 67 71 64 150
109 110 111 153 119 113 122 119 108 115
7.0 7.0 7.3 7.1 7.0 7.2 7.4 7.2 7.3 7.7
7.3 6.8 7.2 7.2 7.3 6.9 7.5 7.4 7.0 7.2
ALB g/dL
4.2 4.0 4.7 4.2 4.2 4.1 4.1 4.2 4.4 4.6
4.2 4.1 4.6 4.0 4.2 4.1 4.4 4.3 4.3 4.6
GLOB g/dL
CALC mg/dL
IPHS mg/dL
NA mmol/L
K mmol/L
CL mmol/L
PHEM
2.8 10.5 3.0 10.6 2.6 10.9 2.9 10.8 2.8 10.5 3.1 10.8 3.3 10.9 3.0 10.4 2.9 11.0 3.1 10.9
3.1 10.4 2.7 10.4 2.6 10.7 3.2 11.2 3.1 10.4 2.8 10.3 3.1 10.9 3.1 10.9 2.7 10.4 2.6 10.9
7.4 145.4 7.3 147.2 7.4 146.1 7.2 146.9 7.6 145.9 7.3 145.9 7.1 146.6 7.3 148.3 7.7 147.5 7.8 145.6
7.8 148.7 7.7 145.7 6.8 146.9 6.6 146.1 6.7 145.9 7.1 146.1 7.7 146.0 7.8 146.9 7.2 146.1 6.8 147.3
6.19 6.50 6.66 5.99 6.23 5.96 5.90 5.90 6.24 6.90
100.7 103.7 101.2 102.1 101.9 101.5 100.4 103.4 101.4
99.8
6.28 5.76 5.96 6.36 5.72 5.46 6.24 5.91 5.72 6.32
102.3 100.4
99.9 96.5 100.3 100.5 102.4 100.1 101.4 101.2
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
oes not conta'n T g ^
717
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS
Animal Number
TRIG mg/dL
GLUC mg/dL
TP g/dL
Male, Group: V - 250 mg/kg - Day 91
641051
98 121 7.8
641089
82 127 6.8
641102
87 116 7.5
641134
36 104 7.0
641137
63 113 7.5
641162
79 123 7.3
641190
44 114 7.1
641197
47 113 6.5
641200 110 117 7.6
641202
59 120 7.0
Male, Group: VII - 1000 mg/kg - Day 91
641067 641077 641086 641095 641097 641132 641157 641166 641201 641223
37 126 6.8 37 114 7.4 35 115 7.0 36 130 6.8 61 117 7.1 61 137 7.4 32 122 6.6 41 114 7.6 45 115 6.8 57 122 7.2
ALB g/dL
4.6 4.3 4.7 4.6 4.5 4.7 4.4 4.3 4.8 4.6
4.4 4.7 4.6 4.7 5.0 4.9 4.4 5.1 4.5 4.9
GLOB g/dL
CALC mg/dL
IPHS mg/dL
NA mmol/L
K mmol/L
CL mmol/L
PHEM
3.2 11.4 2.5 10.6 2.8 10.8 2.4 10.7 3.0 11.0 2.6 11.1 2.7 11.0 2.2 10.2 2.8 10.9 2.4 10.5
8.9 148.9 7.2 146.3 7.3 146.9 7.8 147.8 7.3 146.7 7.4 147.6 8.2 145.7 7.8 147.0 7.2 148.7 7.7 147.3
6.39 5.63 6.21 6.02 6.27 6.15 6.23 6.39 5.85 5.54
101.8 100.4 100.9 102.1 100.9 100.6
98.5 101.7 101.7 100.1
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
2.4 10.1
7.5 145.2
5.64
100.3
NONE
2.7 10.5
7.2 144.9
5.78
101.0
NONE
2.4 10.0
7.7 147.7
5.88
104.0
NONE
2.1
10.5
10.1
142.4
7.26
101.5
NONE
2.1 10.4
7.2 145.3
6.20
101.9
NONE
2.5 10.5
7.8 145.8
6.16
101.9
NONE
2.2 10.1
7.6 145.5
5.95
101.8
NONE
2.5 10.6
7.0 146.7
6.27
100.9
NONE
2.3 10.1
6.9 146.8
6.00
102.4
NONE
2.3 10.5
7.5 144.0
6.36
101.4
NONE
Does notcontain TSCACSt
718
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS
Animal Number
PLIP
PICT
PFLU g/wL
Male, Group: I - 0 mg/kg - Day 91
641069 641070 641094 641147 641149 641155 641172 641206 641214 641222
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Male, Group: III - 50 mg/kg - Day 91
641055 641056 641073 641081 641144 641146 641178 641198 641218 641224
NONENONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
0.1 0.1 0.1 0.1 0.1 0.1 QNS 0.1 0.1 0.1
DuPont-4739
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS
Animal Number
PLIP
PICT
PFLU g/itiL
Male, Group: V - 250 mg/kg - Day 91
641061 641089 641102 641134 641137 641162 641190 641197 641200 641202
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.1 0.1 0.1 QNS 0.1 0.1 0.1 0.1 QNS 0.1
Male, Group: VII - 1000 mg/kg - Day 91
641067 641077 641086 641095 641097 641132 641157 641166 641201 641223
NONE' NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
DuPont-4739
Company Sanitized. Does not contain T3CA CB
720
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Genration Reproductive Evaluations
DuPont-4739
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS
Animal Number
SHEM
SLIP
SICT
Male, Group : I - 0 mg/kg - Day 123
641083 641084 641085 641101 641105 641123 641154 641159 641165 641215
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Male, Group: VII - 1000 mg/kg - Day 123
641064 641092 641143 641153 641167 641185 641189 641203 641213 641216
NONENONE NONE TRACE NONE TRACE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
AST IU/L
82 69 84 80 75 74 106 73 75 74
117 67 71 90
155 85 95
453 93 79
ALT IU/L
SDH IU/L
34 20.6 27 15.2 32 18.8 34 21.8 33 18.7 32 14.7 40 23.1 30 22.6 29 14.0 53 24.9
48 18.6 36 15.5 40 18.9 54 19.7 RNV 45.0 45 21.5 65 18.1 520 133.0 41 20.4 37 16.4
ALKP IU/L
BILI mg/dL
BUN mg/dL
CREA mg/dL
CHOL mg/dL
66 6684 73 83 85 61 78 103 103
0.12 <0.10
0.10 0.12 <0.10 <0.10 0.10 <0.10 <0.10 0.12
114 <0.10 115 <0.10
83 <0.10 160 <0.10 161 <0.10 144 <0.10 136 <0.10 215 0.11 105 <0.10 116 <0.10
16 0.34 16 0.39 15 0.29 12 0.35 14 0.30 13 0.34 14 0.20 14 0.28 12 0.23 13 0.26
18 0.35 15 0.25 16 0.31 18 0.23 13 0.26 17 0.28 14 0.30 12 0.30 12 0.35 15 0.38
76 69 77 83 61 59 72 65 85 142
52 77 75 38 58 77 65 56 91 48
Company Sanitized. Does not
721
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS
Animal Number
TRIG mg/dL
GLUC mg/dL
TP g/dL
Male, Group: I - 0 mg/kg - Day 123
641083 180 118 7.2
641084 245 126 7.0 641085 120 112 7.1 641101 283 137 7.0 641105 157 110 7.0 641123 213 131 6.7 641154 169 112 6.4 641159 269 131 6.9 641165 157 111 6.8 641215 302 133 7.2
Male, Group: VII - 1000 mg/kg - Day 123
641064 110 113 7.0
641092 180 122 7.0
641143
92 114 7.0
641153
42 130 6.3
641167 153 135 7.3
641185
78 111 7.1
641189
71 124 6.9
641203
79 123 7.3
641213 209 131 7.4
641216 137 116 6.8
ALB g/dL
4.3 4.3 4.2 4.3 4.1 4.0 4.2 4.2 4.0 4.4
4.6 4.5 4.5 4.2 4.6 4.7 4.4 4.6 4.9 4.3
GLOB g/dL
CALC mg/dL
IPHS mg/dL
NA mmol/L
K mmol/L
CL mmol/L
2.9 11.3 2.7 10.7 2.9 11.3 2.7 11.3 2.9 10.8 2.7 11.1 2.2 10.8 2.7 11.0 2.8 10.8 2.8 11.5
2.4 10.8 2.5 11.3 2.5 10.8 2.1 10.4 2.7 11.1 2.4 10.9 2.5 10.6 2.7 11.1 2.5 11.3 2.5 11.3
7.3 145.6 6.8 145.0 7.0 146.7 7.2 147.2 7.3 146.1 7.0 147.3 6.5 145.4 7.4 146.1 6.6 147.6 6.9 147.7
8.2 146.2 7.3 146.9 7.0 148.9 7.8 147.5 7.2 146.6 7.9 146.7 7.2 146.7 7.6 146.3 7.2 146.1 8.0 147.9
5.93 5.83 5.85 6.54 6.23 6.17 5.92 6.29 5.81 5.96
98.1 98.9 98.4 98.0 99.7 100.2 97.7 99.8 100.8 97.1
6.47 6.64 5.93 6.31 6.07 6.51 5.91 6.12 6.10 5.79
99.4 98.7 100.9 102.2 98.8 97.9 99.8 99.4 98.9 98.6
PHEM
NT NT NT NT NT NT NT NT NT NT
NT NT NT NT NT NT NT NT NT NT
npany Sanitized. Does not contain TSCACBS
722
ISompanj' Sanitized. Does not contain TSCA C5
H-24616: Subchronic Toxicity *n Rats with One-Generation Reproductive Evaluations
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS
Animal Number
PLIP
PICT
PFLU
Male, Group: I - 0 mg/kg - Day 123
641083 NT NT NT 641084 NT NT NT 641085 NT NT NT 641101 NT NT NT 641105 NT NT NT 641123 NT NT NT 641154 NT NT NT 641159 NT NT NT 641165 NT NT NT 641215 NT NT NT
Male, Group: VII - 1000 mg/kg - Day 123
641064 NT NT NT 641092 NT NT NT 641143 NT NT NT 641153 NT NT NT 641167 NT NT NT 641185 NT NT NT 641189 NT NT NT 641203 NT NT NT 641213 NT NT NT 641216 NT NT NT
DuPont-4739
723
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR FEMALE RATS
Animal Number
SHEM
SLIP
SICT
AST IU/L
ALT IU/L
Female, Group: II - 0 mg/kg - Day 44
641240
SMALL
NONE
NONE
83
38
641245
SMALL
NONE
NONE
95
37
641249
TRACE
NONE
NONE
74
33
641257
NONE
NONE
NONE
90
35
641283
SMALL
NONE
NONE
79
33
641290
TRACE
NONE
NONE
89
36
641293
NONE
NONE
NONE
79
40
641335
NONE
NONE
NONE
80
35
641344
SMALL
NONE
NONE
78
36
641384
SMALL
NONE
NONE
73
30
lale, Group: IV - 50 mg/kg - Day 44
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
SMALL' SMALL
NONE MODERATE
NONE SMALL
NONE TRACE TRACE SMALL
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
106 79 82
NT-HEMOL 77
214 94 80
152 82
35 30 35 NT-HEMOL 28 104 44 36 95 35
SDH IU/L
ALKP IU/L
BILI mg/dL
BUN mg/dL
CREA mg/dL
CHOL mg/dL
20.5 15.1 23.2 37.1 21.0 17.9 25.8 20.8 19.8 23.1
60 125'
82 118
66 58 93 92 56 64
0.13 0.14 <0.10 0.15 0.11 0.12 0.12 0.10 0.15 0.10
12.7 22.2 21.1 14.6 18.8 57.4 17.3 21.2 32.4 23.6
90 91 112 NT-HEMOL 71 105 81 107 77 85
0.11 0.10 0.11 NT-HEMOL 0.12 0.10 0.15 <0.10 <0.10 <0.10
13 0.48 13 0.45 14 0.42 17 0.49 15 0.38 15 0.43 17 0.42 17 0.48 21 0.45 14 0.37
13 0.33 16 0.46 16 0.38 15 0.38 14 0.34 15 0.41 16 0.36 15 0.41 18 0.45 17 0.42
110 142
91 82 98 118 79 103 102 95
84 94 91 93 63 88 74 101 96 99
Does no?sorta* 'ora CBST
724
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________________________________________________DuPont-4739
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR FEMALE RATS
A nim al Number
SHEM
SLIP
SICT
Female, Group: VI - 250 mg/kg - Day 44
641244 641251 641269 641292 641302 641362 641363 641375 641379 641398
NONE TRACE
NONE SMALL
NONE SMALL
NONE SMALL SMALL SMALL
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Female, Group : VIII - 1000 mg/kg - Day 44
641237 641275 641279 641299 641300 641314 641326 641327 641380 641390
NONE TRACE SMALL SMALL TRACE TRACE TRACE SMALL SMALL SMALL
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
AST IU /L
68 76 85 82 86 80 87 83 87 83
100 92 75 94
135 82 74 62
100 99
ALT IU /L
27 39 38 32 34 32 34 35 43 41
40 36 24 40 41 40 35 31 47 59
SDH IU /L
19.1 20.2 23.1
9.7 24.7 19.2 14.0 12.2 21.5 22.5
22.8 25.3 20.5 20.4 12.4 16.8 18.3 15.2 17.4 34.2
ALKP IU /L
B IL I m g/dL
BUN m g/dL
CREA m g/dL
CHOL m g/dL
72 <0.10 113' <0.10
95 0.11 70 <0.10 98 0.13 81 0.15 68 <0.10 56 0.10 90 <0.10 68 0.10
66 <0.10 82 0.12 58 0.11 81 <0.10 103 <0.10 112 <0.10 78 <0.10 80 <0.10 104 <0.10 54 <0.10
15 0.41 14 0.39 18 0.35 16 0.36 17 0.39 17 0.25 12 0.38 13 0.37 20 0.40 16 0.44
18 0.42 18 0.41 15 0.39 15 0.39 13 0.31 16 0.37 18 0.35 19 0.40 21 0.39 16 0.47
79 77 66 94 74 61 108 98 113 68
69 66 94 71 70 76 71 74 70 87
t a p ! Saniltnd. Does noteonfaln TSC Cflfe
725
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
s s s s s g 3355335335
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR FEMALE RATS
Animal Number
TRIG mg/dL
GLUC mg/dL
TP g/dL
ALB g/dL
GLOB g/dL
Female, Group: II - 1D mg/kg - Day 44
641240 641245 641249 641257 641283 641290 641293 641335 641344 641384
53 104 7.6 5.0 2.6 61 79 7.3 4.8 2.5 25 113 7.2 4.9 2.3 52 89 7.5 5.0 2.5
50 102 7.0 4.7 2.3 54 111 7.9 5.4 2.5
55 98 7.5 4.9 2.6
39 83 7.5 5.0 2.5
33 104 7.3 4.9 2.4
39 88 7.2 5.0 2.2
Female, Group: IV - 50 mg/kg - Day 44
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
31. 30 27 NT-HEMOL 18 58 69 31 43 40
96 6.8 4.8 2.0 95 7.4 4.9 2.5 95 7.9 5.1 2.8 113 NT-HEMOL NT-HEMOL NT-HEMOL
95 6.3 4.3 2.0
103 7.7 5.4 2.3 87 7.4 5.1 2.3
101 7.1 4.8 2.3 85 7.2 5.1 2.1
115 7.2 4.9 2.3
CALC mg/dL
IPHS mg/dL
NA mmol/L
K mmol/L
CL mmol/L
li.i 10.5 11.2 11.4 10.6 11.2 11.2 11.0 10.9 10.9
7.9 144.9 7.2 144.7 8.4 145.9 9.3 149.0 7.6 147.3 7.8 144.3 8.4 147.9 8.0 147.1 7.3 144.8 8.1 145.6
6.64 5.64 5.97 6.75 5.97 6.03 6.77 6.30 6.10 6.37
95.6 100.1
97.4 101.4
99.4 95.6 97.5 101.5 99.5 97.9
10.5 10.9 11.2 10.5 10.2 10.8 10.9 10.6 11.2 10.6
7.2 8.6 8.9 NT-HEMOL 8.1 6.5 7.8 7.8 8.1 7.0
146.7 146.5 144.6 NT-HEMOL 146.9 144.0 145.4 147.9 146.2 147.9
5.69 6.46 5.90 NT-HEMOL 5.51 6.01 5.81 6.23 6.51 5.93
101.6 98.3 98.3
NT-HEMOL 101.9 96.9 100.6 99.8 98.5 100.7
(WPWy Sanitized. Does not
'rCA CBf
726
H-24616: Subchronic Toxicity j^OjDay_Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR FEMALE RATS
Animal Number
TRIG mg/dL
GLUC mg/dL
TP g/dL
Female, Group: VI - 250 mg/kg - Day 44
641244 641251 641269 641292 641302 641362 641363 641375 641379 641398
16 98 6.8 26 109 7.0 43 84 7.1 56 103 6.7 28 105 6.8 29 102 6.5 46 117 7.7 41 101 6.8
31 116 7.0 24 101 7.2
Female, Group: VIII - 1000 mg/kg - Day 44
641237 641275 641279 641299 641300 641314 641326 641327 641380 641390
11 110 7.5 39 96 7.4 34 120 7.9 33 95 7.5 35 99 7.0 21 98 7.0 16 85 7.2 40 103 7.7 26 100 7.5 31 124 8.3
ALB g/dL
4.4 4.9 5.0 4.7 4.8 4.7 5.5 4.8 4.5 5.0
5.5 5.4 5.7 5.4 4.9 4.7 5.1 5.3 4.9 5.8
GLOB g/dL
CALC mg/dL
IPHS mg/dL
NA mmol/L
K mmol/L
CL mmol/L
2.4 10.5 2.1 10.6 2.1 11.2 2.0 10.6 2.0 10.2 1.8 10.0 2.2 10.8 2.0 10.1 2.5 10.5 2.2 10.9
2.0 10.3 2.0 10.9 2.2 11.1 2.1 11.0 2.1 10.3 2.3 10.5 2.1 11.0 2.4 11.0 2.6 10.3 2.5 RNV
8.0 145.8 6.8 145.5 8.4 146.6 9.7 143.1 6.2 146.9 6.5 147.7 6.6 146.1 7.3 144.5 7.6 147.2 8.3 145.9
7.1 147.5 6.9 147.2 7.9 147.9 8.3 146.1 7.7 144.6 8.5 144.4 8.2 147.4 7.8 146.2 8.4 144.2 8.2 146.1
5.88 6.02 6.20 6.05 5.54 6.11 5.46 6.27 6.11 6.44
99.2 99.9 99.1 103.2 102.1 102.8 99.8 101.7 99.3 98.8
5.89 5.70 6.46 6.04 6.08 6.36 6.05 6.39 5.69 6.68
103.0 100.9
99.9 100.8 103.8 100.8 100.0 100.2 102.1 102.1
PHEM
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
______________
INDIVIDUAL SERUM AMD PLASMA CHEMISTRY VALUES FOR FEMALE RATS
Animal Number
PLIP
PICT
PFLU
Female, Group: II - 0 mg/kg - Day 44
641240 NT NT NT 641245 NT NT NT 641249 NT NT NT 641257 NT NT NT 641283 NT NT NT 641290 NT NT NT 641293 NT NT NT
641335 NT NT NT
641344 NT NT NT
641384 NT NT NT
Female, Group: IV - 50 mg/kg - Day 44
641260 NT NT NT
641298 NT NT NT
641311 NT NT NT
641312 NT NT NT
641313 NT NT NT
641336 NT NT NT
3 O
641355 NT NT NT
641361 NT NT NT
641369 NT NT NT
641396 NT NT NT
i
DuPont-4739
728
Company Sanitized. Does not co
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR FEMALE RATS
Animal Number
PLIP
PICT
PFLU
Female, Group: VI - 250 mg/kg - Day 44
641244 NT NT NT 641251 NT NT NT 641269 NT NT NT 641292 NT NT NT 641302 NT NT NT 641362 NT NT NT 641363 NT NT NT 641375 NT NT NT 641379 NT NT NT 641398 NT NT NT
Female, Group: VIII - 1000 mg/kg - Day 44
641237 641275 641279 641299 641300 641314 641326 641327 641380 641390
NT- NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT
NT NT NT NT NT NT NT NT NT NT
DuPont-4739
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________________________________________________ ______ DuPont-4739
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR FEMALE RATS
Animal Number
SHEM
SLIP
SICT
Female, Group: II - 0 mg/kg - Day 92
641240 641245 641249 641257 641283 641290 641293 641335 641344 641384
NONE TRACE
NSR NONE TRACE NONE NONE NONE TRACE NONE
NONE NONE
NT NONE NONE NONE NONE NONE NONE NONE
NONE NONE
NT NONE NONE NONE NONE NONE NONE NONE
Female, Group : IV - 50 mg/kg - Day 92
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
TRACENONE NONE
TRACE TRACE
NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
AST IU/L
87 109
NT 93 82 66 103 115 70 63
114 77 84
101 82 85
151 106 126 207
ALT IU/L
28 58 NT 38 32 26 43 58 20 23
67 31 35 35 31 31 79 80 84 150
SDH IU/L
16.2 23.5
NT 20.1 20.6 22.0 20.8 33.0 17.8 22.1
27.8 20.4 19.6 18.1 17.1 27.5 26.2 26.1 25.5 55.8
ALKP IU/L
BILI mg/dL
BUN mg/dL
CREA mg/dL
CHOL mg/dL
39 0.18 81 0.17 NT NT 47 0.18 48 0.18 31 0.24 88 0.12 53 0.19 27 0.21 41 0.18
54 0.17 46 0.17 66 0.16 54 0.21 50 0.20 114 0.11 66 0.10 55 0.14 37 0.15 36 0.19
13 0.48 15 0.42 NT NT 15 0.45 16 0.44 14 0.41 15 0.53 17 0.63 16 0.46 11 0.36
17 0.44 16 0.57 16 0.48 15 0.36 18 0.44 16 0.48 23 0.44 12 0.44 19 0.48 15 0.57
107 120
NT 85 92 115 94 98 116 106
100 105
89 98 59 86 88 109 95 108
Company Sanitized. Does not contain TSCA CB1
730
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR FEMALE RATS
Animal Number
SHEM
SLIP
SICT
Female, Group: VI - 250 mg/kg - Day 92
641244 641251 641269 641292 641302 641362 641363 641375 641379 641398
TRACE NONE NONE
TRACE TRACE TRACE
NONE TRACE
NONE TRACE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Female, Group: VIII - 1000 mg/kg - Day 92
641237 641275 641279 641299
641300 641314 641326 641327 641380 641390
NONE TRACE TRACE
NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
AST XU/L
89 66 117 91 77 82 68 72 137 70
160 87 80 99 71 83 77 68
120 61
ALT IU/L
SDH IU/L
35 19.4 37 19.6 41 28.7 58 25.5 30 19.0 37 19.9 34 17.8 38 20.1 106 30.6 34 19.7
66 15.2 35 21.0 27 20.6 41 20.0 35 16.3 40 19.1 36 21.2 28 20.6 55 27.7 31 19.1
ALKP IU/L
BILI mg/dL
BUN mg/dL
CREA mg/dL
CHOL mg/dL
44 0.14 59. 0.17 70 0.15 50 0.17 66 0.18 56 0.16 35 0.19 35 0.16 42 0.12 45 0.11
40 0.13 62 0.11 48 <0.10 71 0.14 61 0.11 90 0.13 61 0.10 56 <0.10 61 0.11 28 0.11
17 0.48 19 0.49 15 0.54 18 0.54 16 0.40 15 0.47 14 0.47 14 0.41 16 0.43 16 0.42
20 0.50 17 0.48 13 0.47 18 0.49 15 0.33 19 0.47 21 0.49 18 0.52 20 0.42 17 0.47
83 75 72 93 64 59 151 72 109 53
94 66 84 62 65 82 85 91 70 80
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
@mpanySanitized. Does not conta
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR FEMALE RATS
Animal Number
TRIG mg/dL
GLUC mg/dL
TP g/dL
Female, Group: II - 0 mg/kg - Day 92
641240
39 113 7.9
641245
48 101 7.5
641249 NT NT NT
641257
57 102 8.0
641283
51 125 8.0
641290 127 129 8.5
641293
59 107 8.0
641335
41 157 7.9
641344
40 107 8.0
641384
52 115 7.9
Female, Group: IV - 50 mg/kg - Day 92
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
31 107 7.4 60 114 7.9 38 106 8.3 40 108 8.3 26 95 7.0 75 142 8.1 72 114 8.1 35 109 8.0 78 101 7.6 72 118 9.0
ALB g/dL
5.2 4.7
NT 5.3 5.3 5.7 5.0 5.1 5.1 5.4
5.1 5.2 5.3 5.5 4.6 5.5 5.5 5.3 5.2 6.2
GLOB g/dL
CALC mg/dL
IPHS mg/dL
NA mmol/L
K mmol/L
CL mmol/L
2.7 10.8 2.8 10.7
NT NT 2.7 11.1 2.7 11.1 2.8 12.0 3.0 11.1 2.8 10.9 2.9 11.2 2.5 11.2
2.3 11.1 2.7 11.1 3.0 11.3 2.8 11.0 2.4 10.6 2.6 11.2 2.6 11.4 2.7 11.0 2.4 11.3 2.8 11.8
RNV 146.7 5.5 148.3 NT NT 5.8 146.7 5.2 148.6 6.0 147.2 5.7 150.3 3.1 147.2 5.1 147.3 4.5 147.3
5.5 148.5 6.0 148.1 6.1 145.8 4.4 146.6 6.1 147.3 5.0 147.9 5.0 148.5 6.0 149.1 5.3 146.9 4.9 147.2
5.75 5.77
NT 5.29 5.30 5.80 5.84 5.44 6.01 5.86
103.9 104.4
NT 104.3 102.5
99.0 103.4 103.9 102.7 103.8
5.58 6.12 5.58 5.57 5.22 5.72 5.97 5.76 5.81 5.32
105.0 103.9 102.4 103.2 103.2 103.9 106.7 103.9 103.1 103.1
PHEM
NONE NONE NSR NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR FEMALE RATS
A nim al Number
TRIG m g/dL
GLUC m g/dL
TP g /d L
Female, Group: VI - 250 mg/kg - Day 92
641244 27 96 7.6
641251
55 106 7.9
641269
54 102 7.9
641292
77 122 7.9
641302
29 100 7.2
641362
26 105 6.9
641363 185 121 9.0
641375
50 112 7.4
641379
36 120 8.1
641398
44 105 7.5
Female, Group: VIII - 1000 mg/kg - Day 92
641237 641275 641279 641299 641300 641314 641326 641327 641380 641390
41- 168 32 107 44 122 48 143 55 100 26 118 41 159 80 112 47 171 52 125
8.0 8.0 8.4 8.1 6.8 7.8 8.0 8.8 7.9 8.9
ALB g /d L
4.9 5.4 5.2 5.3 4.8 4.9 6.0 5.1 5.3 5.1
5.5 5.5 5.8 5.6 4.7 5.0 5.4 5.7 5.3 6.0
GLOB g /d L
CALC m g/dL
IPHS m g/dL
NA m m ol/L
K m m ol/L
CL m m ol/L
2.7 10.8 2.5 11.5 2.7 12.0 2.6 11.1 2.4 10.7 2.0 11.0 3.0 12.1 2.3 10.5 2.8 11.2 2.4 11.3
2.5 10.6 2.5 11.2 2.6 11.3 2.5 11.0 2.1 10.9 2.8 10.9 2.6 11.4 3.1 11.5 2.6 11.0 2.9 11.9
5.4 5.17.1 6.0 5.6 5.9 5.2 5.8 4.7 5.9
147.7 147.1 151.6 148.2 148.5 147.2 145.6 148.2 149.8 146.8
6.1 147.4 4.9 148.9 5.2 148.6 4.9 147.3 6.2 145.1 6.4 147.2 5.4 147.4 5.9 147.5
5.2 148.5 5.6 148.5
5.22 5.82 6.71 5.28 5.69 5.90 5.13 5.93 5.50 5.56
104.3 102.9 106.2 102.5 104.0 103.5 100.7 106.5 104.7 102.0
6.75 5.35 6.12 5.75 5.99 5.88 5.69 5.53 5.70 5.41
107.9 103.0 105.1 104.5 103.0 103.3 102.2 102.1 106.9 104.0
PHEM
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
SIC W3S1,
733
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________________________________________________DuPont-4739
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR FEMALE RATS
Animal Number
PLIP
PICT
PFLU g/mL
Female, Group: II - 0 mg/kg - Day 92
641240 641245 641249 641257 641283 641290 641293 641335 641344 641384
NONE NONE
NT NONE NONE NONE NONE NONE NONE NONE
NONE NONE
m NONE NONE NONE NONE NONE NONE NONE
0.2 0.2 NSR 0.2 0.3 0.2 QNS 0.1 0.2 0.2
Female, Group: IV - 50 mg/kg - Day 92
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
NONENONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.3 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
'C&mparty Sanitized. Does not contain tsca n qs
734
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations__________________________________________
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR FEMALE RATS
Animal Number
PLIP
PICT
PFLU ig/mL
Female, Group: VI - 250 mg/kg - Day 92
641244 641251 641269 641292 641302 641362 641363 641375 641379 641398
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.2 0.2 0.1 0.2 0.2 0.1 0.2 0.2 0.3 0.2
lale, Group: VIII - 1000 mg/kg - Day 92
641237 641275 641279 641299 641300 641314 641326 641327 641380 641390
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.2 0.3 0.2 0.2 0.2 0.2 0.3 0.2 0.3 0.2
DuPont-4739
Does notcontain TSCACBS
735
J
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________
DuPont-4739
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR FEMALE RATS
Animal Number
SHEM
SLIP
SICT
Female, Group: II - 0 mg/kg - Day 124
641253 641266 641281 641294 641325 641331 641359 641364 641383 641400
TRACE NONE NONE NONE NONE NONE
TRACE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Female, Group: VIII - 1000 mg/kg - Day 124
641234 641256 641282 641352 641356 641366 641377 641385 641387 641399
NONENONE NONE NONE
NSR NONE NONE NONE NONE NONE
NONE NONE NONE NONE
NT NONE NONE NONE NONE NONE
NONE NONE NONE NONE
NT NONE NONE NONE NONE NONE
AST iu/L
69 107 120
90 98 102 99 88 142 99
76 69 74 65 NT 598 76 89 81 243
ALT IU/L
SDH IU/L
26 20.6 48 26.1 89 28.9 96 24.9 93 28.4 58 18.9 37 23.6 40 24.8 108 38.8 44 26.0
39 15.1 36 16.7 31 19.0 32 13.1 NT NT 590 226.0 35 22.7 50 23.4 27 20.0 277 52.9
ALKP IU/L
BILI mg/dL
BUN mg/dL
CREA mg/dL
CHOL mg/dL
40 0.12 37 0.18 38 0.16 41 0.18 33 0.21 72 0.17 51 0.12 32 0.10 27 0.15 32 0.10
60 0.11 29 <0.10 41 <0.10 36 0.13 NT NT 45 0.14 33 0.12 37 <0.10 76 0.12 35 <0.10
15 0.43 15 0.44 16 0.40 14 0.39 14 0.44 10 0.37 13 0.40 16 0.45 15 0.41 17 0.36
14 0.37 17 0.45 15 0.47 14 0.42 NT NT 14 0.42 14 0.40 17 0.44 14 0.48 20 0.61
68 129 110 154 144
80 79 93 105 92
70 120
74 126
NT 143
65 136
86 73
orapanj Sanftfzed. Does no! contain TSCA CBI
736
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR FEMALE RATS
Animal Number
TRIG mg/dL
GLUC mg/dL
TP g/dL
Female, Group: II - 0 mg/kg - Day 124
641253 83 90 7.3
641266
64 106 8.4
641^ai
62 123 9.0
641294 108 118 8.6
641325
52 112 9.3
641331
35 109 7.9
641359 53 96 7.7
641364
60 103 8.1
641383
54 110 8.7
641400 47 99 8.1
Female/ Group: VIII - 1000 mg/kg - Day 124
641234 641256 641282 641352 641356 641366 641377 641385 641387 641399
50' 57 105 62 NT 54 20 58 41 -53
115 116 100 109
NT 102
96 85 99 118
7.7 8.4 8.1 8.5 NT 8.5 7.6 8.5 8.1 8.3
ALB g/dL
4.7 5.5 6.2 5.7 6.5 5.6 5.2 5.3 6.0 5.5
5.4 6.1 5.0 5.8 NT 5.5 5.4 5.8 5.3 5.6
GLOB g/dL
CALC mg/dL
IPHS mg/dL
NA mmol/L
K mmol /L
CL mmol/L
2.6 11.1 2.9 11.8 2.8 12.3 2.9 12.0 2.8 12.4 2.3 11.2 2.5 11.0 2.8 11.5 2.7 11.9 2.6 11.4
2.3 11.1 2.3 11.8 3.1 11.8 2.7 11.9
NT NT 3.0 12.0 2.2 11.2 2.7 11.8 2.8 11.5 2.7 11.6
6.7 6.8' 7.5 6.3 5.6 5.7 6.5 6.0 6.1 5.8
145.1 146.2 145.5 144.9 146.1 146.8 146.8 145.1 145.2 145.3
6.6 145.9 6.4 147.1 7.4 149.2 6.1 145.9 NT NT 6.0 146.1 6.3 147.9 6.8 146.5 6.9 147.0 6.2 146.7
6 .10 6 .41 6 .47 5 .28 4 .89 5 .08 5 .94 5..44 5 .27 5..79
99.8 99.5 96.8 96.8 94.3 97.2 99.1 96.6 98.5 99.5
5..47 5..22 5..36 5..52
NT 5.,18 5. 95 5. 30 5. 43 5. 22
101.2 98.1 97.2 97.5 NT 94.3
101.1 97.5 98.5
100.5
if Sgif ;? ggggggggSU
PHEM
CerapMf SanRFzeef. Doesnocoran TSCACSF
737
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________________________________________________DuPont-4739
INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR FEMALE RATS
Animal Number
PLIP
PICT
PFLU
Female, Group: Il - 0 mg/kg - Day 124
641253 NT NT NT 641266 NT NT NT 641281 NT NT NT 641294 NT NT NT 641325 NT NT NT 641331 NT NT NT 641359 NT NT NT 641364 NT NT NT 641383 NT NT NT 641400 NT NT NT
Female, Group: VIII - 1000 mg/kg - Day 124
641234 641256 641282 641352 641356 641366 641377 641385 641387 641399
NT- NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT
NT NT NT NT NT NT NT NT NT NT
. Does noi csna.s TSCA CW
738
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL URINALYSIS VALUES FOR MALE RATS
Animal Number
QUAL
COL CLAR
Male, Group: I - 0 mg/kg - Day 44
641069 641070 641094 641147 641149 641155 641172 641206 641214 641222
MEDIUM LIGHT LIGHT
MEDIUM MEDIUM
DARK MEDIUM
LIGHT MEDIUM
LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
Male, Group: III - 50 mg/kg - Day
CLEAR CLEAR CLEAR CLEAR CLEAR CLOUDY CLEAR CLEAR
HAZY CLEAR
641055 641056 641073 641081 641144 641146 641178 641198 641218 641224
MEDIUM LIGHT
MEDIUM LIGHT
MEDIUM MEDIUM MEDIUM
LIGHT MEDIUM MEDIUM
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLEAR CLEAR CLOUDY CLEAR
HAZY CLEAR
HAZY HAZY CLEAR CLOUDY
VOL UOSM mL mOsm/kg
SG
9.4 11.0 16.0
7.0 4.8 8.4 13.4 1.0 4.8 18.0
13.4 12.8
7.0 12.0 12.0 10.2 11.0 22.0
4.6 14.0
1111 967 862
1017 1796 1200 1002
QNS 1705
628
1.037 1.029 1.026 1.033 1.055 1.038 1.030 1.025 1.055 1.021
779 627 1300 753 771 813 1121 677 1692 921
1.024 1.020 1.041 1.024 1.024 1.025 1.036 1.022 1.053 1.029
PH UGLU
KET
mg/dL
mg/dL
UBIL
BLD
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
6.0 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
15 SMALL TRACE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.0 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE
15 NEGATIVE NEGATIVE
7.0 NEGATIVE
15 NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
15 NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
15 NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE
15 NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE
SMALL
SSoB^ws?Sanitized. Doesnot eontaln TSCA GB
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL URINALYSIS VALUES FOR MALE RATS
Animal Number
QUAL
COL CLAR
Male, Group: V - 250 mg/kg - Day 44
641061 641089 641102 641134 641137 641162 641190 641197 641200 641202
MEDIUM MEDIUM MEDIUM MEDIUM
NT MEDIUM
LIGHT MEDIUM MEDIUM MEDIUM
YELLOW YELLOW YELLOW YELLOW
NT YELLOW YELLOW YELLOW YELLOW YELLOW
CLEAR CLEAR CLEAR CLOUDY
NT CLOUDY
CLEAR CLEAR CLEAR CLEAR
Male, Group: VII - 1000 mg/kg - Day 44
641067 641077 641086 641095 641097 641132 641157 641166 641201 641223
LIGHT LIGHT MEDIUM MEDIUM LIGHT
DARK MEDIUM MEDIUM
LIGHT MEDIUM
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLEAR CLEAR CLEAR CLEAR CLEAR CLOUDY
HAZY CLEAR CLEAR CLEAR
VOL UOSM
SG
pH UGLU
KET UBIL
BLD
mL mOsm/kg
mg/dL
mg/dL
3.4 13.0 11.8
8.8 QNS 2.3 18.6 10.0 4.2 4.8
28.0 22.0
7.4 3.6 24.2 2.0 3.4 9.8 10.6 10.0
2771 629 924 959 QNS
2662 539 719
1854 1855
1.077 1.020 1.028 1.029
NT 1.076 1.018 1.024 1.056 1.058
6.0 NEGATIVE 7.0 NEGATIVE 7.0 NEGATIVE 7.0 NEGATIVE NT NT 6.5 NEGATIVE 7.0 NEGATIVE 7.0 NEGATIVE 6.5 NEGATIVE 6.0 NEGATIVE
5 SMALL NEGATIVE
5 NEGATIVE NEGATIVE
5 NEGATIVE NEGATIVE
5 NEGATIVE
TRACE
NT NT NT
15 SMALL NEGATIVE
5 NEGATIVE NEGATIVE
5 NEGATIVE NEGATIVE
5 NEGATIVE NEGATIVE
15 NEGATIVE NEGATIVE
447 486 1347 2363 491 2306 2776 874 695 989
1.014 1.016 1.044 1.069 1.016 1.070 1.076 1.027 1.023 1.030
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.5 NEGATIVE
15 SMALL SMALL
6.5 NEGATIVE
15 NEGATIVE NEGATIVE
7.0 NEGATIVE
15 NEGATIVE NEGATIVE
7.0 NEGATIVE
15 NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
740
J
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________________________________________________DuPont-4739
INDIVIDUAL URINALYSIS VALUES FOR MALE RATS
Animal Number
URO EU/dL
UFLU
UMTP mg/dL
Male, Group: I - 0 mg/kg - Day 44
641069 641070 641094 641147 641149 641155 641172 641206 641214 641222
0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
NT NT NT NT NT NT NT NT NT NT
Male, Group: III - 50 mg/kg - Day 44
641055 641056 641073 641081 641144 641146 641178 641198 641218 641224
0.20.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
NT NT NT NT NT NT NT NT NT NT
in 66 53 89
151 82 60 49
186 41
47 23 89 42 46 40 62 38 157 56
SPEC
FECAL CONTAMINATION OBSERVED sample status: URINALYSIS TO BE RUN MANUALLY - LOW VOLUME FECAL CONTAMINATION OBSERVED
FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED
D@mm i contafnTSCA CB
741
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL URINALYSIS VALUES FOR MALE RATS
Animal Number
URO EU/dL
UFLU
UMTP mg/dL
Male, Group: V - 250 mg/kg - Day 44
641061
1.0
NT 220
641089
0.2
NT
27
641102
0.2
NT
51
641134
0.2
NT
55
641137
NT QNS QNS
641162
1.0
NT
85
641190
0.2
NT
18
641197
0.2
NT
32
641200
0.2
NT 164
641202
0.2
NT
94
Male, Group: VII - 1000 mg/kg - Day 44
641067 641077 641086 641095 641097 641132 641157 641166 641201 641223
0.2 0.2 0.2 0.2 0.2 1.0 1.0 0.2 0.2 0.2
NT 18 NT 16 NT 96 NT 174 NT 14 NT 190 NT 160 NT 49 NT 27 NT 44
SPEC FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED
FECAL CONTAMINATION OBSERVED
DuPont-4739
CBjpanf Sanitized. Does not contain TSCA OBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL URINALYSIS VALUES FOR MALE RATS
Animal Number
QUAL
COL CLAR
Male, Group: 1 - 0 mg/kg - Day 91
641069 641070 641094 641147 641149 641155 641172 641206 641214 641222
MEDIUM MEDIUM
LIGHT MEDIUM MEDIUM MEDIUM MEDIUM
LIGHT MEDIUM MEDIUM
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLEAR HAZY
CLEAR CLOUDY
HAZY HAZY CLEAR HAZY HAZY HAZY
Male, Group: III - 50 mg/kg - Day 91
641055 641056 641073 641081 641144 641146 641178 641198 641218 641224
LIGHT. LIGHT MEDIUM LIGHT LIGHT MEDIUM MEDIUM LIGHT LIGHT MEDIUM
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
HAZY HAZY CLEAR CLEAR CLEAR HAZY CLEAR CLEAR CLEAR HAZY
VOL UOSM mL mOsm/kg
SG
6.4 4.4 7.4 2.4 5.5 5.4 6.8 30.0 10.0 7.1
17.4 4.0 5.4 9.7
14.0 4.3
11.6 17.6 18.8 11.0
1279 1540 1344 1818 1252 1585 1376
465 837 1256
1.042 1.049 1.041 1.056 1.040 1.049 1.044 1.017 1.027 1.039
493 1192 1530 1016
746 1861
817 543 482 1220
1.016 1.038 1.047 1.030 1.025 1.055 1.027 1.018 1.017 1.039
pH UGLU
KET
mg/dL
mg/dL
UBIL
BLD
6.5 NEGATIVE 6.5 NEGATIVE 7.0 NEGATIVE 6.5 NEGATIVE 6.5 NEGATIVE 6.5 NEGATIVE 7.0 NEGATIVE 6.0 NEGATIVE 7.0 NEGATIVE 7.0 NEGATIVE
5 NEGATIVE NEGATIVE
5 NEGATIVE NEGATIVE
5 NEGATIVE NEGATIVE
5 NEGATIVE
TRACE
5 NEGATIVE NEGATIVE
5 SMALL NEGATIVE
5 NEGATIVE NEGATIVE
5 NEGATIVE
TRACE
5 NEGATIVE NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE
TRACE
6.5 NEGATIVE
15 NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
6.0 NEGATIVE
5 NEGATIVE NEGATIVE
6.0 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
15 SMALL TRACE
6.0 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE
TRACE
5.5 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
743
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL URINALYSIS VALUES FOR MALE RATS
Animal Number
QUAL
COL CLAR
Male, Group: V - 250 mg/kg - Day 91
641061 641089 641102 641134 641137 641162 641190 641197 641200 641202
LIGHT MEDIUM MEDIUM
LIGHT MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLEAR HAZY HAZY HAZY HAZY HAZY HAZY HAZY HAZY
CLEAR
Male, Group: VII - 1000 mg/kg - Day 91
641067 641077 641086 641095 641097 641132 641157 641166 641201 641223
LIGHTLIGHT LIGHT MEDIUM LIGHT MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
HAZY CLEAR CLEAR CLEAR CLEAR CLOUDY CLEAR
HAZY CLOUDY
CLEAR
VOL UOSM mL mOsm/kg
SG
9.8 6.8 4.3 5.7 6.4 3.3 11.0 3.6 1.7 4.4
17.2 20.2
7.8 7.8 12.0 8.5 4.0 7.4 3.4 5.8
852 1175 1541 1507 1599 2855 1680 2066 3308 1897
1.027 1.037 1.048 1.045 1.049 1.077 1.028 1.061 1.083 1.058
509 587 1031 1046 715 1257 2145 1151 910 1401
1.017 1.019 1.033 1.034 1.023 1.040 1.063 1.035 1.053 1.044
pH UGLU
KET
mg/dL
mg/dL
UBIL
BLD
6.0 6.5' 7.5 7.0 6.5 6.5 6.0 7.0 6.5 6.0
NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5 NEGATIVE NEGATIVE 5 NEGATIVE NEGATIVE 5 NEGATIVE NEGATIVE 5 NEGATIVE NEGATIVE 5 SMALL NEGATIVE 15 NEGATIVE NEGATIVE 5 NEGATIVE NEGATIVE 5 NEGATIVE NEGATIVE 5 NEGATIVE NEGATIVE 15 NEGATIVE NEGATIVE
6.0 NEGATIVE
5 NEGATIVE NEGATIVE
6.0 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.5 NEGATIVE
15 SMALL TRACE
6.0 NEGATIVE
5 NEGATIVE NEGATIVE
7.5 NEGATIVE
15 NEGATIVE NEGATIVE
6.5 NEGATIVE
15 SMALL NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
Bees notconfata TSCA OBI
744
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL URINALYSIS VALUES FOR MALE RATS
Animal Number
URO EU/dL
UFLU (9
UMTP mg/dL
Male, Group: I - 0 mg/kg - Day 91
641069 641070 641094 641147 641149 641155 641172 641206 641214 641222
0.2 8.9 0.2 9.9 0.2 10.5 1.0 QNS 0.2 8.9 1.0 12.3 0.2 10.4 0.2 19.4 0.2 13.6 0.2 15.6
Male, Group: III - 50 mg/kg - Day
641055 641056 641073 641081 641144 641146 641178 641198 641218 641224
0.20.2 0.2 0.2 0.2 1.0 0.2 0.2 0.2 0.2
18.4 8.7
11.2 11.7 12.6 12.0 19.2 16.5 15.3 15.4
147 142
99 40 108 92 77 40 79 101
22 82 98 35 54 128 29 22 22 77
SPEC
DuPont-4739
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________________________________________________DuPont-4739
INDIVIDUAL URINALYSIS VALUES FOR MALE RATS
Animal Number
URO EU/dL
UFLU m
UMTP mg/dL
Male, Group: V - 250 mg/kg - Day 91
641061 641089 641102 641134 641137 641162 641190 641197 641200 641202
0.2 27.6 0.2 21.8 0.2 21.1 0.2 21.8 0.2 30.5 1.0 32.5 0.2 22.4 1.0 21.9 1.0 QNS 0.2 24.7
38 60 119 78 83 NV 101 148 55 92
Male, Group: VII - 1000 mg/kg - Day 91
641067 641077 641086 641095 641097 641132 641157 641166 641201 641223
0.2' 0.2 0.2 0.2 0.2 0.2 1.0 0.2 1.0 0.2
45.2 42.2 40.7 50.3 43.6 63.1 42.0 37.9
8.7 53.3
41 18 50 30 21 77 75 42 29 65
oes noi contain TSCA CB!
746
Corapany Sanitized. Does not contain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________
DuPont-4739
INDIVIDUAL URINALYSIS VALUES FOR MALE RATS
Animal Number
QUAL
COL CLAR
Male, Group: I - 0 mg/kg - Day 123
641083 641084 641085 641101 641105 641123 641154 641159 641165 641215
MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM
LIGHT LIGHT MEDIUM
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
HAZY HAZY CLEAR CLEAR CLEAR HAZY CLEAR CLEAR CLEAR CLEAR
Male, Group: VII - 1000 mg/kg - Day 123
641064 641092 641143 641153 641167 641185 641189 641203 641213 641216
MEDIUM 'MEDIUM MEDIUM
DARK LIGHT MEDIUM LIGHT LIGHT MEDIUM MEDIUM
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
HAZY HAZY HAZY CLOUDY HAZY CLEAR HAZY HAZY HAZY CLEAR
VOL UOSM mL mOsm/kg
SG
3.4
3095
1.083
4.1
1630
1.051
2.3
1757
1.055
4.5
2628
1.071
4.5
1390
1.046
3.6
1982
1.059
4.2
1766
1.055
9.8 539 1.017
3.2
1214
1.037
4.3
2225
1.066
3.0
3215
1.083
4.1
2464
1.069
3.1
2380
1.071
3.2
2545
1.069
8.2
1199
1.037
3.3
2155
1.065
9.0 900 1.027
9.8 928 1.028
7.9
1200
1.040
2.8
1924
1.061
pH UGLU
KET
mg/dL
mg/dL
UBIL
BLD
6.0 NEGATIVE 6.5 NEGATIVE 6.0 NEGATIVE 6.5 NEGATIVE 6.0 NEGATIVE 7.5 NEGATIVE 6.0 NEGATIVE 8.5 NEGATIVE 5.5 NEGATIVE 6.5 NEGATIVE
15 SMALL NEGATIVE 5 NEGATIVE NEGATIVE
15 NEGATIVE NEGATIVE 15 NEGATIVE NEGATIVE 15 NEGATIVE NEGATIVE 15 NEGATIVE NEGATIVE 15 NEGATIVE NEGATIVE
5 NEGATIVE NEGATIVE 15 NEGATIVE NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE
15 NEGATIVE NEGATIVE
7.0 NEGATIVE
15 NEGATIVE NEGATIVE
6.0 NEGATIVE
15 NEGATIVE NEGATIVE
8.5 NEGATIVE
15 SMALL NEGATIVE
7.5 NEGATIVE
5 NEGATIVE
TRACE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
8.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.5 NEGATIVE
5 NEGATIVE
SMALL
7.5 NEGATIVE
5 NEGATIVE NEGATIVE
6.0 NEGATIVE
15 NEGATIVE NEGATIVE
747
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL URINALYSIS VALUES FOR MALE RATS
Animal Number
URO EU/dL
TJFLU ig
UMTP mg/dL
Male, Group:
641083 641084 641085 641101 641105 641123 641154 641159 641165 641215
Male, Group:
641064 641092 641143 641153 641167 641185 641189 641203 641213 641216
0 mg/kg - Day 123
1.0 16.5 0.2 6.0 0.2 6.6 0.2 19.7 0.2 8.0 0.2 11.4 0.2 7.2 0.2 8.8 0.2 5.0 0.2 13.5
185 174 140 186 109 168 123
26 61 240
- 1000 mg/kg - Day 123
1.0' 0.2 0.2 1.0 0.2 0.2 0.2 0.2 0.2 0.2
15.7 19.3
5.2 12.3 17.1 12.9 16.5 18.7 18.8 11.6
192 175 159 197
. 55 162
34 39 97 184
SPEC
FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED
DuPont-4739
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL URINALYSIS VALUES FOR
Animal Number
QUAL
COL CLAR
Female, Group : II - 0 mg/kg - Day 44
641240 641245 641249 641257 641283 641290 641293 641335 641344 641384
MEDIUM LIGHT
MEDIUM MEDIUM
LIGHT MEDIUM
LIGHT MEDIUM MEDIUM
NT
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
NT
CLEAR CLEAR
HAZY CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR
NT
Female, Group : IV - 50 mg/kg - Day 44
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
LIGHT" LIGHT MEDIUM
NT MEDIUM MEDIUM
LIGHT MEDIUM MEDIUM
LIGHT
YELLOW YELLOW YELLOW
NT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLEAR CLEAR CLEAR
NT CLEAR
HAZY CLEAR CLEAR CLEAR CLEAR
VOL UOSM mL msm/kg
SG
10.8 21.6 13.2
4.0 22.0
9.0 17.0
9.0 7.2 QNS
13.4 12.6
7.6 QNS 5.0 5.2 17.8 11.0 1.5 13.2
959 348 591 970 413 803 464 810 1057 QNS
1.028 1.011 1.019 1.030 1.013 1.025 1.014 1.024 1.030
NT
456 578 987 QNS 1300 1124 342 716 QNS 604
1.014 1.018 1.029
NT 1.041 1.036 1.011 1.022 1.056 1.019
.Cofflpanj Sanitized. Does not contain TSCACBI
749
DuPont-4739
FEMALE RATS
pH UGLU
KET
mg/dL
mg/dL
BIL
BLD
6.5 6.0' 7.0 6.0 6.5 6.0 7.0 6.5 6.5 NT
NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE
NT
NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE
NT
NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE
NT
NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE
NT
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
NT NT NT NT NT
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE
5 SMALL NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
> *& )
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL URINALYSIS VALUES FOR FEMALE RATS
Animal Number
QUAL
COL CLAR
Female, Group : VI - 250 mg/kg - Day 44
641244 641251 641269 641292 641302 641362 641363 641375 641379 641398
MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM
NT LIGHT MEDIUM MEDIUM
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
NT YELLOW YELLOW YELLOW
CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR
NT CLEAR CLEAR CLEAR
Female, Group : VIII - 1000 mg/kg - Day 44
641237 641275 641279 641299 641300 641314 641326 641327 641380 641390
medium" MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM
LIGHT MEDIUM MEDIUM
LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLEAR HAZY
CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR CLOUDY CLEAR
VOL raL
UOSM mOsm/kg
SG
4.3 5.2 3.4 11.6 1.0 2.0 QNS 15.0 8.0 11.4
5.2 7.4 5.0 5.0 8.8 3.4 7.8 6.0 4.4 15.0
1178 907
1659 669 QNS
1937 QNS 526 803 623
1.036 1.027 1.050 1.021 1.064 1.057
NT 1.016 1.024 1.019
984 807 1158 956 684 2003 689 1282 1576 525
1.028 1.024 1.036 1.029 1.022 1.059 1.021 1.039 1.048 1.017
pH UGLU
KET
mg/dL
mg/dL
UBIL
BLD
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE
SMALL NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
NT NT NT NT NT
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE
SMALL NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE
TRACE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
CompanySanitized. Does notcontain TSCACBI
750
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL URINALYSIS VALUES FOR FEMALE RATS
Animal Number
URO EU/dL
UFLU
UMTP mg/dL
Female, Group: II - 0 mg/kg - Day 44
641240 641245 641249 641257 641283 641290 641293 641335 641344 641384
0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
NT 16 NT <6 NT 14 NT 25 NT 8 NT 15 NT <6 NT 15 NT 9 NT QNS
Female, Group: IV - 50 mg/kg - Day 44
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
0.20.2 0.2
NT 0.2 0.2 0.2 0.2 0.2 .0,2
NT 6 NT 8 NT 19 NT QNS NT 16 NT 28 NT 7 NT 11 NT 56 NT 8
SPEC
FECAL CONTAMINATION OBSERVED
FECAL CONTAMINATION OBSERVED Sample status: URINALYSIS TO BE RUN MANUALLY - LOW VOLUME
DuPont-4739
oes notcontain TSCA CBI
751
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL URINALYSIS VALUES FOR FEMALE RATS
Animal Number
UR0 EU/dL
UFLU
UMTP mg/dL
Female, Group: VI - 250 mg/kg - Day 44
641244 641251 641269 641292 641302 641362 641363 641375 641379 641398
0.2 0.2 0.2 0.2 0.2 0.2 NT 0.2 0.2 0.2
NT 17 NT 19 NT 23 NT 12 NT 54 NT 33 NT QNS NT 9 NT 18 NT 9
Female, Group: VIII - 1000 mg/kg - Day 44
641237 641275 641279 641299 641300 641314 641326 641327 641380 641390
O.Z 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 .0.2
NT 16 NT 15 NT 18 NT 21 NT 15 NT 41 NT 8 NT 21 NT 45 NT 9
SPEC Sample ststus: URINALYSIS TO BE RUN MANUALLY - LOW VOLUME
FECAL CONTAMINATION OBSERVED
DuPont-4739
QfflpanfSanitized. Does not contain TSCA CBI
752
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL URINALYSIS VALUES FOR FEMALE RATS
Animal Number
QUAL
COL CLAR
Female, Group : II - 0 mg/kg - Day 92
641240 641245 641249 641257 641283 641290 641293 641335 641344 641384
LIGHT LIGHT MEDIUM LIGHT MEDIUM MEDIUM LIGHT MEDIUM LIGHT MEDIUM
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR
HAZY CLEAR CLEAR
Female, Group : IV - 50 mg/kg - Day 92
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM
LIGHT MEDIUM MEDIUM MEDIUM
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLEAR CLEAR
HAZY HAZY CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR
VOL UOSM mL mOsm/kg
SG
13.0 8.7 8.0
16.2 4.4 8.1 9.4 6.1 5.9 6.4
3.8 7.1 4.9 2.7 3.2 4.5 4.4 4.0 3.0 5.2
544 646 1170 447 1401 1098 692 1018 829 754
1.018 1.020 1.034 1.015 1.043 1.034 1.020 1.030 1.025 1.024
1215 933
1057 1987 1893 1262
608 1278 1322
992
1.038 1.028 1.031 1.058 1.054 1.040 1.020 1.038 1.041 1.030
PH UGLU
KET
mg/dL
mg/dL
UBIL
BLD
6.0 NEGATIVE NEGATIVE NEGATIVE
TRACE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE n e g a t i v e 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
f
M
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL URINALYSIS VALUES FOR
Animal Number
QUAL
COL CLAR
Female, Group : VI - 250 mg/kg - Day 92
641244 641251 641269 641292 641302 641362 641363 641375 641379 641398
MEDIUM MEDIUM MEDIUM
LIGHT LIGHT MEDIUM MEDIUM LIGHT MEDIUM LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
HAZY CLEAR
HAZY CLEAR
HAZY HAZY CLEAR HAZY CLEAR HAZY
Female, Group : VIII - 1000 mg/kg - Day 92
641237 641275 641279 641299 641300 641314 641326 641327 641380 641390
MEDIUMMEDIUM
NT MEDIUM
LIGHT MEDIUM MEDIUM
LIGHT MEDIUM
LIGHT
YELLOW YELLOW
NT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLEAR HAZY NT
CLOUDY CLEAR CLEAR
CLOUDY CLEAR CLEAR HAZY
VOL UOSM mL mOsm/kg
SG
4.4 5.1 3.7 5.6 11.6 6.2 1.5 10.0 6.5 3.0
2.1 2.7 NSR 1.8 15.6 2.7 2.5 8.6 3.0 13.6
1598 1016 1320 1188
447 1070 2508
785 1053
695
1.047 1.030 1.041 1.037 1.015 1.031 1.073 1.024
1.031 1.022
1810 1686
NT 2036
438 2280 1163
705 1461
606
1.053 1.051
NT 1.061 1.015 1.065 1.036 1.022 1.046 1.020
fDoesnefconfa? * *
754
DuPont-4739
FEMALE RATS
pH UGLU
KET
mg/dL
mg/dL
UBIL
BLD
6.5 NEGATIVE NEGATIVE NEGATIVE
TRACE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE
SMALL NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
NT NT NT NT NT
6.0 NEGATIVE
5 SMALL MODERATE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE
SMALL NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE
TRACE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL URINALYSIS VALUES FOR FEMALE RATS
Animal Number
URO EU/dL
UFLU Mg
UMTP mg/dL
Female, Group: II - 0 mg/kg - Day 92
641240 641245 641249 641257 641283 641290 641293 641335 641344 641384
0.2 11.1 0.2 9.1 0.2 13.4 0.2 9.0 0.2 6.8 0.2 10.7 0.2 7.8 0.2 10.8 0.2 6.3 0.2 10.0
Female, Group: IV - 50 mg/kg - Day 92
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
0.20.2 0.2 1.0 0.2 0.2 0.2 0.2 0.2 .0.2
7.7 12.9
6.5 10.0
9.0 10.5
5.2 7.7 6.2 6.5
12 17 21
9 30 39
7 18 14 22
27 15 25 42 25 33 16 25 21 23
DuPont-4739
-J
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________
INDIVIDUAL URINALYSIS VALUES FOR FEMALE RATS
Animal Number
URO EU/dL
UFLU M3
UMTP mg/dL
Female, Group: VI - 250 mg/kg - Day 92
641244 641251 641269 641292 641302 641362 641363 641375 641379 641398
0.2 14.6 0.2 12.9 0.2 12.6 0.2 10.7 0.2 15.2 0.2 16.1 1.0 QNS 0.2 21.7 0.2 16.2 0.2 5.7
26 17 25 21
7 15 408 12 24 10
Female, Group: VIII - 1000 mg/kg - Day 92
I 641237 641275 641279
0.2 QNS 0.2 18.0 NT NSR
37 35 NSR
3 641299 641300
1.0 QNS 0.2 33.6
92 6
1
641314 641326
1.0 26.5 0.2 10.1
53 11
f
641327
0.2 27.7
15
1
641380
0.2 20.1
37
2
641390
0.2 30.1
10
r%
a
756
DuPont-4739
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL URINALYSIS VALUES FOR FEMALE RATS
A nim al Number
QUAL
COL CLAR
641253 641266 641281 641294 641325 641331 641359 641364 641383 641400
641234 641256 641282 641352 641356 641366 641377 641385 641387 641399
: II - 0 mg/kg - Day 124
MEDIUM LIGHT
MEDIUM MEDIUM MEDIUM
LIGHT MEDIUM MEDIUM
LIGHT LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLOUDY CLEAR CLEAR HAZY CLEAR CLEAR CLEAR HAZY HAZY CLEAR
: VIII - 1000 mg/kg - Day 124
LIGHT MEDIUM MEDIUM MEDIUM
NT MEDIUM MEDIUM
LIGHT MEDIUM
LIGHT
YELLOW YELLOW YELLOW YELLOW
NT YELLOW YELLOW YELLOW YELLOW YELLOW
CLEAR CLEAR
HAZY CLEAR
NT HAZY CLEAR CLEAR HAZY HAZY
VOL UOSM mL mOsm/kg
SG
8.6 6.8 1.9 4.0 2.7 10.4 3.0 4.5 13.4 10.0
7.7 5.8 4.1 4.6 NSR 3.8 3.0 7.8 4.2 5.7
1116 1253 2781 1555 1592
471 1639 1446
538 515
1.035 1.039 1.078 1.050 1.048 1.018 1.051 1.046 1.018 1.017
705 1122 1883 1150
NT 1122 1579
840 1550 1088
1.023 1.036 1.056 1.037
NT 1.037 1.048 1.026 1.049 1.036
PH UGLU
KET
mg/dL
mg/dL
UBIL
BLD
7.5 NEGATIVE NEGATIVE NEGATIVE MODERATE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE
5 NEGATIVE
TRACE
5.5 NEGATIVE NEGATIVE NEGATIVE
SMALL
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE
TRACE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
NT NT NT NT NT
5.5 NEGATIVE NEGATIVE NEGATIVE
SMALL
6.0 NEGATIVE
5 NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE
TRACE
6.0 NEGATIVE NEGATIVE NEGATIVE
TRACE
J
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________________________________________________DuPont-4739
INDIVIDUAL URINALYSIS VALUES FOR FEMALE RATS
Animal Number
URO EU/dL
UFLU Mg
UMTP mg/dL
Female, Group: II - 0 mg/kg - Day 124
641253 641266 641281 641294 641325 641331 641359 641364 641383 641400
0.2 5.7 0.2 11.4 0.2 m 0.2 9.9 0.2 5.8 0.2 16.3 0.2 4.5 0.2 9.2 0.2 9.8 0.2 10.1
43 24 73 42 58
9 46 36 15
8
Female, Group: VIII - 1000 mg/kg - Day 124
641234 641256 641282 641352 641356 641366 641377 641385 641387 641399
0.2. 0.2 0.2 0.2
NT 0.2 0.2 0.2 0.2 0.2
12.0 11.1 14.3 11.0
NSR 6.9 7.5 11.1 10.0 12.0
18 15 47 24 NSR 48 24 18 38 39
SPEC FECAL CONTAMINATION OBSERVED
FECAL CONTAMINATION OBSERVED
Des not contain TSCA CfW
758
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL URINE MICROSCOPIC VALUES FOR MALE RATS
Animal Number
EPIT
UWBC
URBC
Male, Group: I - 0 mg/kg - Day 44
641069 641070 641094 641147 641149 641155 641172 641206 641214 641222
NONE FEW FEW FEW FEW FEW
NONE FEW FEW FEW
1-10 1-10
0 0 1-10 1-10 0 1-10 1-10 1-10
Male, Group: III - 50 mg/kg - Day 44
641055 641056 641073 641081 641144 641146 641178 641198 641218 641224
FEW FEW FEW NONE FEW FEW FEW NONE NONE FEW
0 1-10 1-10
0 0 1-10 1-10 0 1-10 0
0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0
NCRY
MICR
NONE FEW FEW
NONE NONE
FEW NONE
FEW FEW FEW
FEW MODERATE MODERATE MODERATE
FEW MODERATE
FEW FEW FEW FEW
FEW NONE
FEW FEW NONE FEW FEW FEW NONE FEW
FEW FEW FEW FEW MODERATE FEW FEW FEW FEW MODERATE
SPER
SPEC
0 1 2 2 2 3 FEW GRANULAR CASTS 0 3 sample status: BELOW RECOMMENDED VOLUME 2 1
1 1 2 1 2 0 3 1 2 1
BOSS nfCOfffgirs
!
5 3
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL URINE MICROSCOPIC VALUES FOR MALE RATS
Animal Number
EPIT
UWBC
URBC
NCRY
MICR
Male, Group: V - 250 mg/kg - Day 44
641061 641089 641102 641134 641137 641162 641190 641197 641200 641202
NONE FEW
NONE FEW NT FEW FEW FEW FEW FEW
0 0 0 1-10 NT 0 0 1-10 1-10 1-10
0 0 0 0 NT 0 0 0 0 0
Male, Group : VII - 1000 mg/kg - Day 44
641067 641077 641086 641095 641097 641132 641157 641166 641201 641223
NONE NONE
FEW FEW FEW FEW FEW FEW FEW NONE
0 0 1-10 1-10 0 1-10 0 1-10 0
0 0 0 0 0 0 0 0 0 0
NONE NONE
FEW FEW
NT FEW NONE NONE NONE NONE
NONE NONE NONE NONE NONE MODERATE
FEW NONE NONE NONE
MODERATE FEW FEW FEW NT
MODERATE FEW FEW FEW FEW
MODERATE FEW FEW FEW
MODERATE MANY FEW FEW FEW FEW
SPER
2 1 1 3 NT 1 0 0 2 2
2 2 0 1 0 0 3 1 0 0
760
DuPont-4739
i
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______
INDIVIDUAL URINE MICROSCOPIC VALUES FOR MALE RATS
Animal Number
EPIT
TJWBC
URBC
NCRY
MICR
SPER
SPEC
Male, Group:: I - 0 mg/kg - Day 91
641069
FEW
0
0 NONE MODERATE
3
641070
FEW
0
0 FEW MODERATE
3 1-MUCUS
641094
FEW
0
0 FEW MANY
3
641147 MODERATE
1-10
1-10
NONE
MANY
3
641149
FEW
0 1-10 NONE MODERATE
3
641155
NONE
0 0 FEW MODERATE
3
I
641172
FEW
0 0 NONE MODERATE
1
641206
NONE
0 0 NONE MODERATE
3
641214
FEW
0
0 FEW FEW
3
641222
FEW
0
0 FEW MODERATE
3 1-MUCUS
Male, Group: III - 50 mg/kg - Day 91
641055 641056 641073 641081 641144 641146 641178 641198 641218 641224
NONEFEW FEW FEW
NONE NONE
FEW FEW NONE FEW
0 0 NONE MODERATE
0 0 NONE MODERATE
0 0 FEW MODERATE
0 1-10 NONE
FEW
0 0 NONE MANY
0 0 FEW MODERATE
0 0 NONE MODERATE
0 1-10 NONE
FEW
0
0 NONE
FEW
0 0 NONE MANY
2 3 1-MUCUS 1 1-MUCUS 1 1-MUCUS 2 1-MUCUS 2 1-MUCUS 3 0 2 1 1-MUCUS
DuPont-4739
s noteonfafn TSCACB
761
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL URINE MICROSCOPIC VALUES FOR MALE RATS
Animal Number
EPIT
UWBC
URBC
NCRY
MICH
Male, Group: V - 250 mg/kg - Day 91
641061 641089 641102 641134 641137 641162 641190 641197 641200 641202
NONE NONE
FEW NONE NONE
FEW NONE
FEW FEW FEW
0 0 0 0 1-10 0 0 0 0 0
0 0 0 0 1-10 1-10 0 0 0 0
NONE NONE
FEW FEW NONE FEW NONE FEW MODERATE NONE
FEW MODERATE
FEW MODERATE MODERATE
MANY FEW FEW
MANY MODERATE
Male, Group: VII - 1000 mg/kg - Day 91
641067 641077 641086 641095 641097 641132 641157 641166 641201 641223
FEW FEW FEW NONE FEW FEW NONE FEW FEW NONE
0
0 NONE
FEW
0
0 NONE
FEW
0 1-10 NONE MODERATE
0 0 NONE MANY
0
0 NONE
FEW
0 0 FEW MANY
0
0 NONE
FEW
0
0 MODERATE
FEW
0 0 FEW MANY
0 0 FEW FEW
SPER
SPEC
2 3 2 3 3 1 2-MUCUS 3 2 2-MUCUS 2 Sample status BELOW RECOMMENDED VOLUME; 1-MUCUS 1 1-MUCUS
3 3 1 1-MUCUS 2 3 1-MUCUS 2 3 3 3 1 1-MUCUS
Does not contain TSCA CBl
762
H-24616: Subchronic Toxicity 90-DayGavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL URINE MICROSCOPIC VALUES FOR MALE RATS
Animal Number
EPIT
UWBC
URBC
NCRY
MICR
SPER
SPEC
Male, Group: I - 0 mg/kg - Day 123
641083 4.LU4 641085 641101 641105 641123 641154 641159 641165 641215
FEW FEW FEW NONE FEW NONE NONE NONE NONE FEW
Male, Group: VII -
0
1-10 1-10
0 0 0 1-10 0 0 0
0 0 0 0 0 0 0 0 0
mg/kg - Day 123
FEW FEW NONE FEW NONE MODERATE NONE FEW FEW FEW
FEW FEW FEW FEW FEW FEW FEW MODERATE FEW FEW
3 3 3 2 3
3 1-MUCUS 1 1-MUCUS 2 1 1 1-MUCUS
oprata ioumoq T o p p *
641064 641092
FEW NONE
1-10 0
0 FEW 0 MODERATE
FEW FEW
2 1-MUCUS 1 1-MUCUS
641143
NONE
0 0 FEW FEW
3
641153
NONE
0
0 FEW FEW
3
641167
NONE
0 0 MODERATE MODERATE
2
641185
FEW 1-10
0 NONE
FEW
3
641189
NONE
0
0 FEW FEW
2
641203
NONE
0
0 FEW FEW
1
641213
NONE
0
0 FEW FEW
1 1-MUCUS
<0
641216
FEW 1-10
0 MODERATE
FEW
3
DuPont-4739
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL URINE MICROSCOPIC VALUES FOR FEMALE RATS
Animal Number
EPIT
UWBC
URBC
Female, Group: II - 0 mg/kg - Day 44
641240 641245 641249 641257 641283 641290 641293 641335 641344 641384
FEW NONE
FEW FEW NONE NONE NONE NONE NONE
NT
0 1-10 1-10
0 0 0 0 0 0 NT
0 0 0 0 0 0 0 0 0 NT
Female, Group: IV - 50 mg/kg - Day 44
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
FEW NONE
FEW NT
FEW NONE
FEW NONE
FEW NONE
0 0 1-10 NT 1-10 0 0 0 1-10 0
0 0 0 NT .0 0 0 0 0 0
NCRY
NONE FEW
NONE NONE NONE NONE NONE NONE NONE
NT
NONE NONE NONE
NT NONE NONE NONE NONE
FEW NONE
MICR
FEW FEW FEW FEW FEW FEW FEW FEW FEW
NT
NONE FEW FEW NT FEW FEW FEW FEW FEW FEW
SPER
SPEC
0 0 0 0 0 0 0 0 0 NT
0 0 0 NT 0 0 0 0 0 sample status: BELOW RECOMMENDED VOLUME 0
Des notcontain TSCAC
764
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL URINE MICROSCOPIC VALUES FOR FEMALE RATS
A nim al Number
EPIT
UWBC
URBC
NCRY
MICR
Female, Group: VI - 250 mg/kg - Day 44
641244 641251 641269 641292 641302
FEW NONE NONE NONE
FEW
1-10 0 0 0
1-10
0 0 0 0 0
641362 641375 641379 641398
NONE FEW
NONE NONE
0 1-10
0 0
0 0 0 0
Female, Group: VIII - 1000 mg/kg - Day 44
NONE NONE NONE NONE NONE
FEW NONE NONE NONE
FEW FEW MODERATE FEW FEW
FEW FEW FEW FEW
641237 641275 641279 641299 641300 641314 641326 641327 641380 641390
FEW NONE
FEW NONE NONE NONE NONE NONE NONE NONE
0 0 0 1-10 1-10 0 0 1-10 0 1-10
0 NONE
FEW
0 NONE
FEW
0 FEW FEW
0 NONE
FEW
0 NONE
FEW
0 NONE MODERATE
0 NONE MODERATE
0 NONE
FEW
0 MODERATE
MANY
0 NONE
FEW
SPER
SPEC
0 0 0 0 0 Sample status: BELOW RECOMMENDED VOLUME;
FEW GRANULAR CASTS 0 0 0 0
0 0 0 0 0 0 0 0 0 0
Company Sanitized. Does not contain TSCA CEI
765
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL URINE MICROSCOPIC VALUES FOR FEMALE RATS
A nim al Number
EPIT
WBC
URBC
NCRY
MICR
Female, Group: II - 0 mg/kg - Day 92
641240 641245 641249 641257 641283 641290 641293 641335 641344 641384
FEW NONE
FEW FEW FEW FEW FEW FEW FEW FEW
0 0 0 0 0 0 0 1-10 0 0
Female, Group: IV - 50 mg/kg - ]
641260 641298 641311 641312 641313 641336 641355 641361 641369 641396
FEWFEW FEW FEW FEW FEW FEW NONE FEW FEW
0 1-10 1-10 1-10 1-10
0 0 0 1-10 0
0 FEW FEW
0 FEW FEW
0 FEW FEW
0 FEW FEW
0 FEW FEW
0 FEW FEW
0 MODERATE MODERATE
0 MODERATE MODERATE
0 MODERATE
FEW
0 MODERATE MODERATE
0 MODERATE
FEW
0 MODERATE MODERATE
0 MODERATE MODERATE
0 MODERATE MODERATE
0 FEW MODERATE
0 MODERATE
FEW
0 FEW FEW
0 FEW FEW
0 MODERATE MODERATE
0 FEW FEW
SPER
SPEC
0 0 0 0 0 0 0 0 0 0
0 0 0 1-MUCUS 0 Sample status: BELOW RECOMMENDED VOLUME 0 0 0 1-MUCUS 0 1-MUCUS 0 sample status: BELOW RECOMMENDED VOLUME; 1-MUCUS 0
fMmy Sanitized. Does notcontain TSCCBS
766
IIP
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL URINE MICROSCOPIC VALUES FOR FEMALE RATS
Animal Number
EPIT
UWBC
URBC
NCRY
MICR
Female, Group: VI - 250 mg/kg - Day 92
641244 641251 641269 641292 641302 641362 641363 641375 641379 641398
FEW NONE
FEW FEW FEW MODERATE FEW NONE NONE FEW
1-10 0 0
1-10 0
1-10 0 0 0 0
0 FEW FEW
0 MODERATE MODERATE
0 MODERATE
FEW
0 FEW FEW
0 MODERATE MODERATE
0 MODERATE
FEW
0 MODERATE
FEW
0 FEW FEW
0 FEW FEW
0 MANY MANY
Female, Group: VIII - 1000 mg/kg - Day 92
641237 641275 641279 641299 641300 641314 641326 641327 641380 641390
FEW* FEW
NT MODERATE
FEW FEW MODERATE FEW FEW NONE
1-10 0
NT 1-10
0 1-10 1-10
0 1-10 1-10
0 MODERATE MODERATE
0 MODERATE
MANY
NT NT NT
0 MANY
MANY
0 FEW FEW
0 MODERATE MODERATE
0 MANY MODERATE
0 FEW FEW
0 MODERATE MODERATE
0 FEW FEW
SPER
SPEC
0 0 0 0 1-MUCUS 0 0 1-MUCUS 0 Sample status: BELOW RECOMMENDED VOLUME; 1-MUCUS 0 0 0 Sample status: BELOW RECOMMENDED VOLUME
0 Sample status : BELOW RECOMMENDED VOLUME; 1-MUCUS 0 Sample status : BELOW RECOMMENDED VOLUME NT
0fui Sample status : BELOW RECOMMENDED VOLUME; 1-MUCUS
0 Sample status : BELOW RECOMMENDED VOLUME 0 Sample status : BELOW RECOMMENDED VOLUME o 0 Sample status : BELOW RECOMMENDED VOLUME; 1-MUCUS 0
SanffFzed. oes not contain T S C A C B I
767
sj
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL URINE MICROSCOPIC VALUES FOR FEMALE RATS
A nim al Number
EPIT
UWBC
URBC
Female, Group: II - 0 mg/kg - Day 124
641253 641266 641281 641294 641325 641331 641359 641364 641383 641400
NONE FEW
NONE FEW FEW
NONE NONE
FEW FEW FEW
0 1-10
0 0 0 1-10 0 1-10 0 0
0 0 0 0 0 0 0 0 0 0
le, Group: VIII - 1000 mg/kg - Day 124
641234 641256 641282 641352 641356 641366 641377 641385 641387 641399
NONE FEW
NONE FEW NT FEW FEW
NONE NONE
FEW
0 0 1-10 1-10 NT 11-50 0 0 0 1-10
0 0 0 0 NT 0 0 0 0 0
NCRY
MICR
FEW NONE NONE
FEW FEW NONE FEW FEW FEW NONE
MODERATE FEW FEW
MODERATE FEW FEW FEW FEW FEW FEW
NONE FEW FEW
NONE NT
NONE NONE
FEW FEW NONE
FEW FEW MODERATE FEW
NT FEW FEW FEW MODERATE MODERATE
SPER
SPEC
0 0 0 Sample status: BELOW RECOMMENDED VOLUME 0 0 0 0 0 0 0
0 0 0 0 NT 0 1-MUCUS 0 1-MUCUS 0 0 0
Does notconfai TSCA CBl
768
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
APPENDIX K INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS
y p M . sam o . Docanot contata TSCA CBI
769
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H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION
Group : I - 0 mg/kg/day Sex :MALES
ANIMAL 1 FBW
BRAIN
1 (Gms) (Gms) %FBW
ADRENAL GLANDS
EPIDIDYMIDES
|
HEART
(Gms) %FBW %BRAIN (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN
641069 641070 641094 641147 641149 641155 641172 641206 641214 641222
1 629.0 1 587.7 1 608.4 1 491.3 1 509.1 1 500.4 1 580.9 1 636.8 1 612.4 1 556.0
Mean S.D.
1 571.2 1 54.3
2.016 0.3205 2.040 0.3471 2.051 0.3371 2.001 0.4073 2.059 0.4044 2.187 0.4371 2.085 0.3589 2.365 0.3714 2.109 0.3444 2.250 0.4047
2.116 0.3733 0.117 0.0380
0.054 0.0086 2.6786 1 1.551 0.2466 76.935 1 1.944 0.3091 96.429 0.058 0.0099 2.8431 1.512 0.2573 74.118 1.588 0.2702 77.843 0.064 0.0105 3.1204 1.623 0.2668 79.132 1.710 0.2811 83.374 0.055 0.0112 2.7486 1.301 0.2648 65.017 1 1.556 0.3167 77.761 0.057 0.0112 2.7683 1.440 0.2829 69.937 1.527 0.2999 74.162
0.035 0.0070 1.6004 0.048 0.0083 2.3022 0.051 0.0080 2.1564 0.060 0.0098 2.8450 0.060 0.0108 2.6667
1.359 0.2716 62.140 1.551 0.2670 74.388 1.671 0.2624 70.655 1.724 0.2815 81.745 1.497 0.2692 66.533
1.512 0.3022 69.136 1.921 0.3307 92.134 1.901 0.2985 80.381 1.914 0.3125 90.754 1.642 0.2953 72.978
1I 0.054 0.0095 2.5730 1 1.523 0.2670 72.060 I 1.722 0.3016 81.495
0.008 0.0015 0.4382 1 0.132 0.0107 6.3444 0.180 0.0174 9.0249
DuPont-4739
KIDNEYS (Gms) %FBW %BRAIN
4.325 0.6876 214.53 4.003 0.6811 196.23 4.102 0.6742 200.00 3.755 0.7643 187.66 3.893 0.7647 189.07 3.558 0.7110 162.69 3.969 0.6833 190.36 4.951 0.7775 209.34 4.856 0.7929 230.25 3.767 0.6775 167.42
4.118 0.7214 194.76 0.464 0.0477 20.470
Group : III - 50 mg/kg/day Sex :MALES
ANIMAL
FBW BRAIN (Gms) (Gms-) %FBW
ADRENAL GLANDS
EPIDIDYMIDES
HEART
KIDNEYS
(Gms) %FBW %BRAIN (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN I (Gms) %FBW %BRAIN
641055 641056 641073 641081 641144 641146 641178 641198 641218 641224
507.3 560.0 580.9 498.9 582.2 482.4 540.6 653.4 481.0 652.1
2.121 0.4181 2.095 0.3741 2.053 0.3534 1.976 0.3961 2.124 0.3648 2.102 0.4357 2.052 0.3796 2.164 0.3312 2.090 0.4345 2.165 0.3320
0.047 0.0093 2.2159 1 1.575 0.3105 74.257 1 1.649 0.3251 77.746 1 4.089 0.8060 192.79 0.046 0.0082 2.1957 1 1.551 0.2770 74.033 1 1.519 0.2713 72.506 1 3.977 0.7102 189.83 0.058 0.0100 2.8251 1 1.408 0.2424 68.583 1 1.648 0.2837 80.273 1 4.267 0.7345 207.84 0.046 0.0092 2.3279 1 1.612 0.3231 81.579 1 1.585 0.3177 80.213 1 3.339 0.6693 168.98 0.065 0.0112 3.0603 1 1.538 0.2642 72.411 1 1.727 0.2966 81.309 1 4.041 0.6941 190.25 0.051 0.0106 2.4263 1 1.361 0.2821 64.748 1 1.681 0.3485 79.971 1 3.755 0.7784 178.64 0.043 0.0080 2.0955 1 1.481 0.2740 72.173 1 1.602 0.2963 78.070 1 4.120 0.7621 200.78 0.060 0.0092 2.7726 1 1.440 0.2204 66.543 1 1.704 0.2608 78.743 1 5.068 0.7756 234.20 0.043 0.0089 2.0574 1 1.370 0.2848 65.550 1 1.475 0.3067 70.574 1 3.824 0.7950 182.97 0.048 0.0074 2.2171 1 1.323 0.2029 61.109 1 1.803 0.2765 83.279 1 4.234 0.6493 195.57
Mean S.D.
553.9 2.094 0.3820 64.0 0.057 0.0386
0.051 0.0092 2.4194 1 1.466 0.2681 70.099 1 1.639 0.2983 78.268 1 4.071 0.7375 194.18 0.008 0.0012 0.3459 1 0.100 0.0374 5.9564 1 0.098 0.0269 3.9157 1 0.443 0.0546 17.864
FBW - Final Body Weight
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
Group : V - 250 mg/kg/day
INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS
Sex :MALES
DESIGNATED FOR 90-DAY EXPOSURE EVALUATION
DuPont-4739
ANIMAL
641061 641089 641102 641134 641137 641162 641190 641197 641200 641202
Mean S.D.
FBW 1
BRAIN
(Gms) 1(Gms) %FBW
557.6 1 2.205 0.3954 500.7 1 2.071 0.4136
524.6 1 2.255 0.4299 463.7 1 2.109 0.4548 547.7 1 2.099 0.3832
507.3 1 2.077 0.4094 532.7 1 2.102 0.3946 511.0 1 1.997 0.3908 526.8 1 2.119 0.4022 580.3 1 2.037 0.3510
525.2 1 2.107 0.4025 32.6 1 0.075 0.0277
ADRENAL GLANDS (Gms) %FBW %BRAIN
0.053 0.0095 2.4036 0.058 0.0116 2.8006 0.057 0.0109 2.5277 0.053 0.0114 2.5130 0.055 0.0100 2.6203 0.049 0.0097 2.3592 0.053 0.0099 2.5214 0.062 0.0121 3.1047 0.051 0.0097 2.4068 0.068 0.0117 3.3382
0.056 0.0107 2.6596 0.006 0.0010 0.3262
EPIDIDYMIDES
|
HEART
| KIDNEYS
(Gms) %FBW %BRAIN (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN
1.546 0.2773 70.113 1.334 0.2664 64.413 1.468 0.2798 65.100 1.371 0.2957 65.007 1.520 0.2775 72.415 1.538 0.3032 74.049 1.473 0.2765 70.076 1.342 0.2626 67.201 1.416 0.2688 66.824 1.453 0.2504 71.330
1.446 0.2758 68.653 0.078 0.0154 3.3985
1.668 2991 75.646 I 4.594 0.8239 208.34 1.507 3010 72.767 I 3.803 0.7595 183.63 1.807 3445 80.133 I 4.608 0.8784 204.35 1.338 2885 63.442 I 3.829 0.8257 181.56 1.789 3266 85.231 I 4.549 0.8306 216.72 1.583 3120 76.216 I 4.370 0.8614 210.40 1.444 0, 2711 68.696 I 4.488 0.8425 213.51 1.558 O'.3049 78.017 I 4.020 0.7867 201.30 1.566 0. 2973 73.903 I 4.274 0.8113 201.70 1.756 0. 3026 86.205 4.432 0.7637 217.57
I 1.602 0.3048 76.026 4.297 0.8184 203.91 0.154 0.0200 6.9647 0.307 0.0391 12.595
Group : VII - 1000 mg/kg/day Sex :MALES
ANIMAL
FBW 1
BRAIN
(Gms) I(Gmsl %FBW
ADRENAL GLANDS (Gms) %FBW %BRAIN
641067 641077 641086 641095 641097 641132 641157 641166 641201 641223
Mean S.D.
426.5 1 1.882 0.4413 499.5 1 2.110 0.4224 464.6 1 2.093 0.4505 422.6 1 2.070 0.4898 462.1 1 2.010 0.4350 490.9 1 2.161 0.4402 420.2 1 2.055 0.4891 456.2 1 2.290 0.5020 446.9 1 2.062 0.4614 445.9 J 2.144 0.4808
1
453.5 1 2.088 0.4612 27.1 1 0.106 0.0275
0.037 0.0087 1.9660 0.053 0.0106 2.5118 0.046 0.0099 2.1978 0.045 0.0106 2.1739 0.034 0.0074 1.6915 0.057 0.0116 2.6377 0.048 0.0114 2.3358 0.053 0.0116 2.3144 0.038 0.0085 1.8429 0.043 0.0096 2.0056
0.045 0.0100 2.1677 0.008 0.0015 0.2961
EPIDIDYMIDES (Gms) %FBW %BRAIN
1.287 0.3018 68.385 1.529 0.3061 72.464 1.450 0.3121 69.279 1.344 0.3180 64.928 1.336 0.2891 66.468 1.479 0.3013 68.441 1.427 0.3396 69.440 1.612 0.3534 70.393 1.656 0.3706 80.310 1.310 0.2938 61.101
1.443 0.3186 69.121 0.127 0.0271 5.0341
HEART (Gms) %FBW %BRAIN
1.272 0 1.531 0 1.430 0 1.330 0 1.375 0 1.652 0 1.281 0 1.427 0 1.765 0 1.456 0
67.588 72.559 68.323 64.251 68.408 76.446 62.336 62.314 85.597 67.910
1.452 0 0.159 0
KIDNEYS (Gms) %FBW %BRAIN
4.462 1.0462 237.09 4.484 0.8977 212.51 4.061 0.8741 194.03 4.034 0.9546 194.88 3.474 0.7518 172.84 5.198 1.0589 240.54 3.829 0.9112 186.33 4.277 0.9375 186.77 3.559 0.7964 172.60 4.082 0.9155 190.39
4.146 0.9144 198.80 0.501 0.0958 23.958
FBW - Final Body Weight
TSCA CB!
771
eonlan TSCA c n
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION
Group
0 mg/kg/day Sex :MALES
1 ANIMAL 1 (Gms)
LIVER %FBW %BRAIN
SPLEEN (Gms) %FBW %BRAIN
TESTES (Gms) %FBW %BRAIN
THYMUS
1
(Gms) %FBW %BRAIN j
1 641069 1 641070
641094 641147 641149 1 641155 641172 641206 641214 1 641222 I
Mean S.D.
19.077 3.0329 946.28 15.934 2.7112 781.08 16.957 2.7871 826.77 12.243 2.4920 611.84 14.739 2.8951 715.83 13.483 2.6944 616.51 16.341 2.8130 783.74 19.998 3.1404 845.58 17.749 2.8983 841.58 16.478 2.9637 732.36
16.300 2.8428 770.16 2.379 0.1860 104.55
0.869 0.1382 43.105 0.927 0.1577 45.441 0.771 0.1267 37.591 0.603 0.1227 30.135 0.641 0.1259 31.132 0.672 0.1343 30.727 0.916 0.1577 43.933 0.834 0.1310 35.264 0.992 0.1620 47.037 0.881 0.1585 39.156
0.811 0.1415 38.352 0.133 0.0157 6.3942
4.047 0.6434 200.74 3.502 0.5959 171.67 3.441 0.5656 167.77 3.243 0.6601 162.07 3.603 0.7077 174.99 3.116 0.6227 142.48 3.491 0.6010 167.43 3.828 0.6011 161.86 3.629 0.5926 172.07 3.624 0.6518 161.07
3.552 0.6242 168.22 0.266 0.0418 14.618
0.506 0.0804 25.099 0.240 0.0408 11.765 0.473 0.0777 23.062 0.328 0.0668 16.392 0.379 0.0744 18.407 0.256 0.0512 11.706 0.405 0.0697 19.424 0.366 0.0575 15.476 0.570 0.0931 27.027 0.432 0.0777 19.200
0.396 0.0689 18.756 0.105 0.0154 5.1950
Iroup : III - 50 mg/kg/day Sex :MALES
ANIMAL 1(Gms)
LIVER %FBW %BRAIN
SPLEEN (Gms) %FBW %BRAIN
TESTES (Gms) %FBW %BRAIN
THYMUS
1
(Gms) %FBW %BRAIN |
641055 641056 641073 641081 641144 641146 641178 641198 641218 641224
Mean S.D.
13.800 2.7203 650.64 16.068 2.8693 766.97 17.354 2.9874 845.30 16.514 3.3101 835.73 19.408 3.3336 913.75 14.842 3.0767 706.09 16.575 3.0660 807.75 20.381 3.1192 941.82 13.152 2.7343 629.28 20.628 3.1633 952.79
16.872 3.0380 805.01 2.611 0.2135 115.90
0.735 0.1449 34.653 0.801 0.1430 38.234 0.872 0.1501 42.474 0.640 0.1283 32.389 0.860 0.1477 40.490 0.793 0.1644 37.726 0.691 0.1278 33.674 1.059 0.1621 48.937 0.733 0.1524 35.072 1.012 0.1552 46.744
0.820 0.1476 39.039 0.135 0.0123 5.5936
3.708 0.7309 174.82 3.430 0.6125 163.72 3.595 0.6189 175.11 3.153 0.6320 159.56 3.667 0.6299 172.65 3.327 0.6897 158.28 3.383 0.6258 164.86 3.914 0.5990 180.87 3.291 0.6842 157.46 2.957 0.4535 136.58
3.443 0.6276 164.39 0.284 0.0739 12.676
0.350 0.0690 16.502 | 0.250 0.0446 11.933 | 0.486 0.0837 23.673 | 0.449 0.0900 22.723 | 0.281 0.0483 13.230 | 0.409 0.0848 19.458 | 0.347 0.0642 16.910 | 0.469 0.0718 21.673 | 0.147 0.0306 7.0335 | 0.334 0.0512 15.427 |
1 0.352 0.0638 16.856 j 0.107 0.0197 5.2376 |
FBW - Final Body Weight
DuPont-4739
TSC.fi CSi
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION
Group : V - 250 mg/kg/day Sex :MALES
1 ANIMAL
LIVER
i (Gins) %FBW %BRAIN
SPLEEN (Gms) %FBW %BRAIN
1 641061 1 641089 1 641102 1 641134 1 641137 1 641162 1 641190 1 641197 1 641200 1 641202 1 1 Mean 1 S.D.
18.631 3.3413 844.94 16.441 3.2836 793.87 17.634 3.3614 782.00 14.968 3.2279 709.72 19.214 3.5081 915.39 16.548 3.2620 796.73 16.051 3.0131 763.61 16.081 3.1470 805.26 17.127 3.2511 808.26 19.062 3.2849 935.79
17.176 3.2680 815.56 1.427 0.1307 67.738
0.741 0.1329 33.605 0.723 0.1444 34.911 0.803 0.1531 35.610 0.790 0.1704 37.459 0.712 0.1300 33.921 0.708 0.1396 34.088 0.778 0.1460 37.012 0.752 0.1472 37.656 0.701 0.1331 33.082 0.806 0.1389 39.568
0.751 0.1435 35.691 0.040 0.0119 2.1407
TESTES (Gms) %FBW %BRAIN
3.171 0.5687 143.81 3.490 0.6970 168.52 3.749 0.7146 166.25 3.118 0.6724 147.84 3.766 0.6876 179.42 3.490 0.6880 168.03 3.465 0.6505 164.84 3.405 0.6663 170.51 3.625 0.6881 171.07 3.463 0.5968 170.00
3.474 0.6630 165.03 0.213 0.0462 10.887
THYMUS
1
(Gms) %FBW %BRAIN |
0.409 0.0734 18.549 | 0.282 0.0563 13.617 j 0.418 0.0797 18.537 j 0.399 0.0860 18.919 0.238 0.0435 11.339 j 0.264 0.0520 12.711 0.324 0:0608 15.414 j 0.381 0.0746 19.079 j 0.452 0.0858 21.331 j 0.423 0.0729 20.766 j
1 0.359 0.0685 17.026 j 0.076 0.0146 3.4977 j
Group : VII - 1000 mg/kg/day Sex :MALES
1 ANIMAL
LIVER
1 (Gms) %FBW %BRAIN
SPLEEN
1 641067 j 641077
1 641086 j 641095 1 641097 1 641132 1 641157 1 641166 j 641201 1 641223 1I 1 Mean 1 S.D.
14.947 3.5046 794.21 19.083 3.8204 904.41 17.103 3.6812 817.15 17.741 4.1981 857.05 17.631 3.8154 877.16 21.326 4.3443 986.86 16.209 3.8574 788.76 18.115 3.9708 791.05 17.184 3.8452 833.37 18.047 4.0473 841.74
17.739 3.9085 849.18 1.692 0.2438 61.674
0.548 0.1285 29.118 0.636 0.1273 30.142 0.786 0.1692 37.554 0.632 0.1496 30.531 0.589 0.1275 29.303 0.640 0.1304 29.616 0.564 0.1342 27.445 0.639 0.1401 27.904 0.600 0.1343 29.098 0.596 0.1337 27.799
0.623 0.1375 29.851 0.066 0.0130 2.8893
TESTES
3.089 0.7243 164.13 3.981 0.7970 188.67 3.236 0.6965 154.61 3.448 0.8159 166.57 3.366 0.7284 167.46 3.808 0.7757 176.21 3.609 0.8589 175.62 3.801 0.8332 165.98 3.351 0.7498 162.51 4.686 1.0509 218.56
3.638 0.8031 174.03 0.463 0.1013 18.185
THYMUS
0.265 0.0621 14.081 0.420 0.0841 19.905 0.330 0.0710 15.767 0.355 0.0840 17.150 0.188 0.0407 9.3532 0.386 0.0786 17.862 0.185 0.0440 9.0024 0.263 0.0577 11.485 0.320 0.0716 15.519 0.195 0.0437 9.0951
0.291 0.0638 13.922 0.085 0.0167 3.9726
FBW - Final Body Weight
773
DuPont-4739
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Oeneration Reproductive Evaluations
INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR ONE-MONTH RECOVERY EVALUATION
Group : I - 0 mg/kg/day Sex :MALES
ANIMAL
641083 641084 641085 641101 641105 641123 641154 641159 641165 641215
Mean S.D.
FBW BRAIN (Gms) (Gms) %FBW
644.7 558.2 603.3 623.2 653.2 593.8 660.0 618.6 590.9 596.4
2.088 0.3239 2.131 0.3818 2.233 0.3701 2.273 0.3647 2.195 0.3360 2.298 0.3870 2.157 0.3268 2.360 0.3815 2.256 0.3818 2.178 0.3652
614.2 2.217 0.3619 31.9 0.083 0.0241
ADRENAL GLANDS (Gms) %FBW %BRAIN
0.052 0.0081 2.4904 0.041 0.0073 1.9240 0.060 0.0099 2.6870 0.053 0.0085 2.3317 0.059 0.0090 2.6879 0.065 0.0109 2.8285 0.054 0.0082 2.5035 0.058 0.0094 2.4576 0.064 0.0108 2.8369 0.044 0.0074 2.0202
0.055 0.0090 2.4768 0.008 0.0013 0.3124
EPIDIDYMIDES
J
HEART
(Gms) %FBW %BRAIN (Gms) %FBW %BRAIN
1.631 0.2530 78.113 1 2.018 0.3130 96.647 1.514 0.2712 71.046 1.506 0.2698 70.671 1.424 0.2360 63.771 1 1.585 0.2627 70.981 1.429 0.2293 62.868 j 1.721 0.2762 75.715 1.681 0.2573 76.583 j 1.879 0.2877 85.604
1.433 0.2413 62.359 j 1.903 0.3205 82.811 1.737 0.2632 80.529 j 1.983 0.3005 91.933
1.669 0.2698 70.720 j 1.871 0.3025 79.280 1.563 0.2645 69.282 j 1.777 0.3007 78.768 1.531 0.2567 70.294 j 1.743 0.2923 80.028
iI 1.561 0.2542 70.557 1 1.799 0.2926 81.244 0.114 0.0144 6.3873 j 0.165 0.0186 8.3809
DuPont-4739
KIDNEYS (Gms) %FBW %BRAIN
4.533 0.7031 217.10 3.453 0.6186 162.04 4.097 0.6791 183.48 4.394 0.7051 193.31 5.067 0.7757 230.84 4.400 0.7410 191.47 4.823 0.7308 223.60 4.748 0.7675 201.19 4.918 0.8323 218.00 4.112 0.6895 188.80
4.455 0.7243 200.98 0.480 0.0594 21.274
Group : VII - 1000 mg/kg/day Sex MALES
| ANIMAL | FBW
BRAIN
1 I (Gms) (Gms) %FBW
ADRENAL GLANDS (Gms) %FBW %BRAIN
641064 | 550.0 641092 | 686.9 641143 j 614.1 641153 | 459.1 641167 | 591.5 04118b | b&4.2 641189 | 509.5 641203 j 518.5 641213 | 699.0 b41ib j 56 /.1
j Mean j 576.0 S.D. | 75.6
2.333 0.4242 2.195 0.3196 2.235 0.3639 1.875 0.4084 1.979 0.3346 2.215 0.3926 2.088 0.4098 2.123 0.4095 2.214 0.3167 1.994 0.3516
2.125 0.3731 0.141 0.0408
0.051 0.0093 2.1860 0.066 0.0096 3.0068 0.063 0.0103 2.8188 0.049 0.0107 2.6133 0.069 0.0117 3.4866 0.037 0.0066 1.6704 0.058 0.0114 2.7778 0.049 0.0095 2.3081 0.052 0.0074 2.3487 0.063 0.0111 3.1595
0.056 0.0097 2.6376 0.010 0.0017 0.5285
EPIDIDYMIDES (Gms) %FBW %BRAIN
1.578 0.2869 67.638 1.573 0.2290 71.663 1.662 0.2706 74.362 1.263 0.2751 67.360 1.559 0.2636 78.777 1.601 0.2838 72.280 1.447 0.2840 69.301 1.355 0.2613 63.825 1.624 0.2323 73.351 1.690 0.2980 84.754
1.535 0.2685 72.331 0.138 0.0228 6.0533
HEART (Gms) %FBW %BRAIN
1.930 0.3509 82.726 1.844 0.2685 84.009 1.911 0.3112 85.503 1.354 0.2949 72.213 1.756 0.2969 88.732 1.720 0.3049 77.652 1.522 0.2987 72.893 1.661 0.3203 78.238 1.770 0.2532 79.946 1.703 0.3003 85.406
1.717 0.3000 80.732 0.175 0.0266 5.5143
KIDNEYS
4.607 4.821 4.630 3.257 4.731 4.320 3.548 4.538 5.027 4.203
,8376 197.47 ,7018 219.64 ,7539 207.16 7094 173.71 7998 239.06 7657 195.03 6964 169.92 8752 213.75 7192 227.06 7411 210.78
4.368 0.7600 205.36 0.564 0.0605 21.959 |
contain TSCA CSI
FBW - Final Body Weight
774
H-24616: Subchronic Toxicity ^90-DayJjavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR ONE-MONTH RECOVERY EVALUATION
Group : I - 0 mg/kg/day Sex :MALES
ANIMAL 1 1(Gms)
LIVER %FBW %BRAIN
641083 1 19.948 3.0942 955.36 641084 1 15.928 2.8535 747.44 641085 1 16.759 2.7779 750.52 641101 1 20.194 3.2404 888.43 641105 1 17.134 2.6231 780.59 641123 1 18.244 3.0724 793.91 641154 1 19.196 2.9085 889.94 641159 1 18.122 2.9295 767.88 641165 1 16.473 2.7878 730.19 641215 1 18.829 3.1571 864.51
i
Mean S.D.
1 18.083 2.9444 816.88 1 1.477 0.1935 76.660
SPLEEN (Gms) %FBW IBRAIN
0.828 0.1284 39.655 0.804 0.1440 37.729 0.926 0.1535 41.469 0.762 0.1223 33.524 0.836 0.1280 38.087 0.838 0.1411 36.466 0.922 0.1397 42.745 1.066 0.1723 45.169 0.750 0.1269 33.245 0.785 0.1316 36.042
0.852 0.1388 38.413 0.096 0.0151 3.8858
TESTES (Gms) %FBW fcBRAIN
3.351 0.5198 160.49 3.560 0.6378 167.06 3.430 0.5685 153.61 3.269 0.5246 143.82 3.659 0.5602 166.70 3.315 0.5583 144.26 3.670 0.5561 170.14 3.646 0.5894 154.49 3.659 0.6192 162.19 3.472 0.5822 159.41
3.503 0.5716 158.22 0.156 0.0373 9.1412
THYMUS (Gms) %FBW fcBRAIN 1
0.331 0.0513 15.852 1 0.313 0.0561 14.688 I 0.483 0.0801 21.630 1 0.318 0.0510 13.990 1 0.533 0.0816 24.282 1 0.327 0.0551 14.230 1 0.494 0..0748 22.902 1 0.407 0.0658 17.246 1 0.483 0.0817 21.410 1 0.385 0.0646 17.677 1
1 0.407 0.0662 18.391 i 0.085 0.0126 3.8489 1
Gmmpmf Sanitized. Doe
Group : VII - 1000 mg/kg/day Sex :MALES
ANIMAL (Gms)
LIVER %FBW. %BRAIN
SPLEEN
I TESTES
I
(Gms) %FBW %BRAIN I(Sms) %FBW %BRAIN |(Gms)
THYMUS %FBW %BRAIN
641064 641092 641143 641153 641167 641185 641189 641203 641213 641216
20.890 3.7982 895.41 25.042 3.6457 1140.9 22.698 3.6961 1015.6 16.643 3.6251 887.63 21.267 3.5954 1074.6 21.082 3.7366 951.78 18.525 3.6359 887.21 18.644 3.5958 878.19 29.117 4.1655 1315.1 22.186 3.9122 1112.6
0.684 0.1244 29.318 I 3.799 0.6907 162.84 I 0.298 0.0542 12.773 0.880 0.1281 40.091 I 3.725 0.5423 169.70 I 0.440 0.0641 20.046 0.754 0.1228 33.736 I 4.179 0.6805 186.98 I 0.407 0.0663 18.210 0.714 0.1555 38.080 I 3.085 0.6.72 164.53 I 0.248 0.0540 13.227 0.905 0.1530 45.730 I 3.809 0.6440 192.47 I 0.352 0.0595 17.787 0.716 0.1269 32.325 I 3.953 0.7006 178.47 I 0.379 0.0672 17.111 0.824 0.1617 39.464 I 3.294 0.6465 157.76 I 0.262 0.0514 12.548 0.724 0.1396 34.103 I 3.424 0.6604 161.28 I 0.330 0.0636 15.544
0.730 0.1044 32.972 I 3.255 0.4657 147.02 I 0.323 0.0462 14.589 0.785 0.1384 39.368 I 3.718 0.6556 186.46 I 0.327 0.0577 16.399
* 3
Mean S.D.
21.609 3.7407 1015.9 3.552 0.1797 144.75
II 0.772 0.1355 36.519 I 3.624 0.6358 170.75 I 0.337 0.0584 15.823 0.075 0.0176 4.8583 I 0.346 0.0741 14.778 I 0.060 0.0069 2.5330
FBW - Final Body Weight
775
DuPont-4739
H-24616: Subchronic Toxicity j^O-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 3-MONTH RECOVERY EVALUATION
Group : I - 0 mg/kg/day Sex :MALES
| ANIMAL 1
FBW 1 (Gms) |(Gms)
LIVER %FBW
| |
641066 641098 641104 641115 641220
Mean S.D.
470.9 517.0 586.9 764.5 515.4
570.9 115.9
13.329 2.8305 15.218 2.9435 15.426 2.6284 22.263 2.9121 13.908 2.6985
16.029 2.8026 3.594 0.1358
| | | | |
1 1 j
Group : III - 50 mg/kg/day Sex :MALES
| ANIMAL 1
641059 641113 641160 641194 641225
Mean S.D.
FBW (Gms) (Gms)
LIVER %FBW
521.8 747.9 565.5 571.6 660.5
13.529 2.5928 27.573 3.6867 14.528 2.5691 15.399 2.6940 18.422 2.7891
613.5 17.890 2.8663 90.5 5.713 0.4669
| |
| | j | |
1 1 j
FBW - Final Body Weight
DuPont-4739
Does not contain TSCA
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 3-MONTH RECOVERY EVALUATION
Group : V - 250 mg/kg/day Sex :MALES
1 ANIMAL 1
FBW (Gms) (Gms)
LIVER %FBW
1 I
1 641076
1 641141
1 641148
1 641187 11 1 Mean
1 S.D.
517.5 643.2 633.3 665.2
614.8 66.2
14.117 2.7279 19.383 3.0135 17.474 2.7592 20.263 3.0462
17.809 2.8867 2.723 0.1663
Group : VII - 1000 mg/kg/day Sex MALES
1 ANIMAL 1
FBW (Gms) (Gms)
LIVER %FBW
1 1
1 641057 1 641130
641169 1 641196 1 641205 I
1 Mean I S.D.
524.7 514.4 640.5 645.3 816.8
628.3 122.1
14.650 2.7921 17.965 3.4924 21.224 3.3137 17.996 2.7888 27.635 3.3833
19.894 3.1541 4.912 0.3380
| | | | |
| |
FBW - Final Body Weight
)
a
111
DuPont-4739
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
Group : II - 0 mg/kg/day
INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION
Sex :FEMALES
| ANIMAL 1
| 641240 | 641245 1 641257 j 641283 1 641290 1 641293 1 641335 | 641344 1 641384 I | Mean 1 S.D.
FBW |
BRAIN
(Gms) |(Gms) %FBW
349.9 | 1.986 0.5676 290.4 | 1.981 0.6822 289.2 1 1.944 0.6722 318.6 j 1.958 0.6146 367.6 1 1.893 0.5150 303.7 j 2.027 0.6674 290.7 1 1.902 0.6543 280.8 1.940 0.6909 286.9 j 1.967 0.6856
|
308.6 1.955 0.6389 30.8 0.042 0.0612
ADRENAL GLANDS
1
(Gms) %FBW %BRAIN | (Gms)
HEART
KIDNEYS
%FBW %BRAIN | (Gms) %FBW %BRAIN
0.090 0.0257 4.5317 | 1.279 0.3655 64.401 | 2.382 0.6808 119.94 0.084 0.0289 4.2403 | 1.043 0.3592 52.650 j 2.446 0.8423 123.47 0.073 0.0252 3.7551 j 0.985 0.3406 50.669 | 2.303 0.7963 118.47 0.076 0.0239 3.8815 | 1.255 0.3939 64.096 | 2.461 0.7724 125.69 0.059 0.0161 3.1167 1 1.285 0.3496 67.882 1 2.504 0.6812 132.28 0.044 0.0145 2.1707 1 1.178 0.3879 58.115 | 2.104 0.6928 103.80 0.057 0.0196 2.9968 j 1.060 0.3646 55.731 j 2.211 0.7606 116.25 0.066 0.0235 3.4021 | 1.071 0.3814 55.206 | 2.276 0.8105 117.32 0.059 0.0206 2.9995 1 1.056 0.3681 53.686 | 2.207 0.7693 112.20
j 0.068 0.0220 3.4549 | 1.135 0.3679 58.048 | 2.322 0.7562 118.82 0.015 0.0047 0.7273 j 0.115 0.0174 6.0177 | 0.136 0.0589 8.1365
DuPont-4739
LIVER (Gms) %FBW %BRAIN
8.865 2.5336 446.37 8.603 2.9625 434.28 8.166 2.8237 420.06 9.501 2.9821 485.24 10.766 2.9287 568.73 8.493 2.7965 418.99 8.708 2.9955 457.83 8.890 3.1660 458.25 7.647 2.6654 388.76
8.849 2.8727 453.17 0.882 0.1905 51.533
Group IV 50 mg/kg/day Sex :FEMALES
I ANIMAL I FBW I I (Gms)
641260 I 306.0 641298 l 320.3 641311 l 311.6
641312 1 281.1 641313 l 300.5
641336 l 289.8 641355 l 276.0 641361 l 309.7 641369 l 266.8 641396 283.3
Mean S.D.
l 294.5 l 17.6
BRAIN (Gms) %FBW
ADRENAL GLANDS (Gms) %FBW %BRAIN
(Gms)
HEART %FBW %BRAIN
KIDNEYS (Gms) %FBW %BRAIN
1.952 0.6379 1.964 0.6132 1.813 0.5818 2.022 0.7193 1.922 0.6396 1.949 0.6725 1.921 0.6960 1.899 0.6132 1.924 0.7211 2.006 0.7081
1.937 0.6603 0.058 0.0499
0.087 0.0284 4.4570 | 0.066 0.0206 3.3605 | 0.066 0.0212 3.6404 | 0.082 0.0292 4.0554 | 0.061 0.0203 3.1738 | ' 0.063 0.0217 3.2324 | 0.055 0.0199 2.8631 | 0.080 0.0258 4.2127 | 0.066 0.0247 3.4304 | 0.077 0.0272 3.8385 1
1 0.070 0.0239 3.6264 | 0.010 0.0036 0.5071 1
0 0.3131 49.078 | 1 0.3594 58.605 1 0.3257 55.985 | 1 0.4372 60.781 | 1 0.3571 55.827 j 0 0.3364 50.026 | 0 0.3486 50.078 | 1 .022 0.3300 53.818 | 0 0.3501 48.545 | 1 0.3629 51.246 j
1 0.3520 53.399 | 0 0.0340 4.2640 |
2.207 0.7212 113.06 2.579 0.8052 131.31 2.349 0.7539 129.56 2.512 0.8936 124.23 2.226 0.7408 115.82 2.503 0.8637 128.42 2.376 0.8609 123.69 2.498 0.8066 131.54 2.218 0.8313 115.28 2.321 0.8193 115.70
2.379 0.8096 122.86 0.138 0.0566 7.2998
LIVER (Gms) %FBW %BRAIN
9.175 2.9984 470.03 9.045 2.8239 460.54 8.361 2.6832 461.17 8.851 3.1487 437.73 8.033 2.6732 417.95 8.723 3.0100 447.56 9.188 3.3290 478.29 8.732 2.8195 459.82 8.429 3.1593 438.10 8.482 2.9940 422.83
8.702 2.9639 449.40 0.378 0.2144 19.983
FBW - Final Body Weight
Doesnotcontain TSCACBI
778
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION
DuPont-4739
Group : VI - 250 mg/kg/day Sex :FEMALES
| ANIMAL 1 FBW
BRAIN
ADRENAL GLANDS
1 1 (Gms) (Gms) %FBW ! (Gms) %FBW %BRAIN
| 641244 1 295.5 1 641251 1 265.9 1 641269 i 265.9
j 64l2y2 I 331.1 j 641302 1 300.4 j 641362 1 284.6 | 641363 1 387.9 j 6413 /b 1 355.6 j 641379 320.1
| 641398 306.3
||
| Mean
311.3
| S.D. 1 38.8
1.945 0.6582 i 0.059 0.0200 3.0334 1.875 0.7052 i 0.063 0.0237 3.3600 1.923 0.7232 i 0.084 0.0316 4.3682 1.977 0.5971 i 0.059 0.0178 2.9843 1.991 0.6628 i 0.099 0.0330 4.9724 1.974 0.6936 i 0.082 0.0288 4.1540 2.042 0.5264 i 0.121 0.0312 5.9256 1.951 0.5487 i 0.069 0.0194 3.5366 1.895 0.5920 i 0.086 0.0269 4.5383 1.915 0.6252 1 0.057 0.0186 2.9765
1
1.949 0.6332 i 0.078 0.0251 3.9849 0.050 0.0667 i 0.021 0.0059 0.9853
(Gms)
HEART
1 KIDNEYS
%FBW %BRAIN 1 (Gms) %FBW %BRAIN
1.117 0.3780 57.429 | 2.170 0.7343 111.57
0.938 0.3528 50.027 | 2.337 0.8789 124.64
0.912 0.3430 47.426 | 2.239 0.8420 116.43
1.137 0.3434 57.511
2.275 0.6871 115.07
1.035 0.3445 51.984 I 2.473 0.8232 124.21
0.957 0.3363 48.480 | 2.237 0.7860 113.32
1.272 0.3279 62.292 | 3.092 0.7971 151.42
1.222 0.3436 62.635 | 2.818 0.7925 144.44
1.098 0.3430 57.942 | 2.614 0.8166 137.94 1.147 0.3745 59.896 1 2.072 0.6765 108.20
1 1.084 0.3487 55.562 | 2.433 0.7834 124.72
0.121 0.0159 5.6454 1 0.321 0.0655 14.961
LIVER (Gms) %FBW %BRAIN
7.867 2.6623 404.47 8.086 3.0410 431.25 7.990 3.0049 415.50 9.682 2.9242 489.73 8.530 2.8395 428.43 8.401 2.9519 425.58 12.955 3.3398 634.43 9.852 2.7705 504.97 9.797 3.0606 516.99 8.161 2.6644 426.16
9.132 2.9259 467.75 1.553 0.2052 70.864
Group : VIII - 1000 mg/kg/day Sex :FEMALES
ANIMAL | FBW I 'BRAIN
| ADRENAL GLANDS
|
HEART
| KIDNEYS |
LIVER
I
I (Gins) |(Gins) %FBW | (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN |
[ 641237 1 641275 | 641279 | 641299 1 641300 1 641314 1 641326 I 641327 | 641380 j 641390
| Mean | S.D.
235.7 253.3 348.5 244.2 297.9 313.7 253.0 371.2 300.7 318.0
293.6 46.2
1.802 0.7645 1.949 0.7694 1.870 0.5366 1.853 0.7588 2.222 0.7459 1.945 0.6200 1.928 0.7621 1.919 0.5170 1.974 0.6565 1.949 0.6129
1.941 0.6744 0.112 0.0988
0.066 0.0280 3.6626 0.076 0.0300 3.8994 0.055 0.0158 2.9412 0.079 0.0324 4.2634 0.069 0.0232 3.1053 0.080 0.0255 4.1131 0.079 0.0312 4.0975 0.083 0.0224 4.3252 0.080 0.0266 4.0527 0.071 0.0223 3.6429
0.074 0.0257 3.8103 0.009 0.0050 0.4730
1.024 0.4345 56.826 | 0.979 0.3865 50.231 j 1.143 0.3280 61.123 j 0.843 0.3452 45.494 | 1.058 0.3552 47.615 j 1.093 0.3484 56.195 \ 0.880 0.3478 45.643 | 1.393 0.3753 72.590 | 1.101 0.3661 55.775 j 1.047 0.3292 53.720 |
2.516 1.0675 139.62 2.075 0.8192 106.46 2.573 0.7383 137.59 2.201 0.9013 118.78 2.472 0.8298 111.25 2.528 0.8059 129.97 2.164 0.8553 112.24 2.721 0.7330 141.79 2.498 0.8307 126.55 2.383 0.7494 122.27
1.056 0.3616 54.521 2.413 0.8330 124.65 0.152 0.0316 8.2112 j 0.205 0.0983 12.569
8.288 3.5163 459.93 8.063 3.1832 413.70 10.645 3.0545 569.25 8.620 3.5299 465.19 9.026 3.0299 406.21 9.742 3.1055 500.87 8.273 3.2700 429.10 12.673 3.4141 660.40 10.323 3.4330 522.95 10.461 3.2896 536.74
9.611 3.2826 496.43 1.451 0.1865 79.135
FBW - Final Body Weight
Does notcontain TSCA CBI
779
Cwnpw^F SanRfeed. Does not contain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION
Group : II - 0 mg/kg/day Sex :FEMALES
[ ANIMAL |
OVARIES
| SPLEEN
I THYMUS
| UTERUS
|
1 |(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN i(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN |
| 641240 | 0.123 0.0352 6.1934 | 0.564 0.1612 28.399 | 0.353 0.1009 17.774
I 641245 1 0.136 0.0468 6.8652 | 0.493 0.1698 24.886 | 0.289 0.0995 14.589
641257 1 0.135 0.0467 6.9444 1 0.428 0.1480 22.016 1 0.287 0.0992 14.763
| 641283 | 0.197 0.0618 10.061 | 0.503 0.1579 25.689 1 0.179 0.0562 9.1420
1 641290 j 0.158 0.0430 8.3465 1 0.515 0.1401 27.205 | 0.379 0.1031 20.021
1 641293 1 0.105 0.0346 5.1801 1 0.423 0.1393 20.868 I 0.327 0.1077 16.132
1 641335 | 0.107 0.0368 5.6257
0.408 0.1404 21.451 1 0.349 0.1201 18.349
1 641344 1 0.147 0.0524 7.5773
0.560 0.1994 28.866 j 0.339 0.1207 17.474
| 641384 | 0.102 0.0356 5.1856 | 0.420 0.1464 21.352 | 0.271 0.0945 13.777
| | Mean
i11 1
0.134 0.0436 6.8866
0.479 0.1558 24.526 | 0.308 0.1002 15.780
j S.D.
0.030 0.0093 1.6034
0.061 0.0195 3.1957 j 0.060 0.0189 3.2033
0.622 0.1778 31.319 0.435 0.1498 21.959 0.502 0.1736 25.823 0.622 0.1952 31.767 0.479 0.1303 25.304 0.397 0.1307 19.586 0.463 0.1593 24.343 0.416 0.1481 21.443 0.461 0.1607 23.437
0.489 0.1584 24.998 0.082 0.0215 4.1921
Group : IV - 50 mg/kg/day Sex :FEMALES
| ANIMAL
OVARIES
1 (Gms) %FBW %BRAIN
SPLEEN
1 THYMUS
(Gms) %FBW %BRAIN i(Gms) %FBW %BRAIN
641260 641298 641311 641312 641313 b4ijJb 641355 641361 641369 641396
Mean S.D.
0.127 0.0415 6.5061 0.096 0.0300 4.8880 0.132 0.0424 7.2808 0.158 0.0562 7.8140 0.141 0.0469 7.3361 0.114 0.0393 5.8492 0.120 0.0435 6.2467 0.129 0.0417 6.7930 0.147 0.0551 7.6403 0.074 0;0261 3.6889
0.124 0.0423 6.4043 0.025 0.0094 1.3046
0.612 0.2000 31.352 | 0.290 0.0948 14.857 0.575 0.1795 29.277 | 0.303 0.0946 15.428 0.498 0.1598 27.468 | 0.226 0.0725 12.466 0.553 0.1967 27.349 j 0.307 0.1092 15.183 0.526 0.1750 27.367 1 0.288 0.0958 14.984 0.453 0.1563 23.243 | 0.309 0.1066 15.854 0.476 0.1725 24.779 1 0.206 0.0746 10.724 0.375 0.1211 19.747 1 0.382 0.1233 20.116 0.620 0.2324 32.225 1 0.292 0.1094 15.177 0.432 0.1525 21.535 | 0.179 0.0632 8.9232
1 0.512 0.1746 26.434 | 0.278 0.0944 14.371 0.080 0.0306 4.0854 1 0.059 0.0191 3.0705
UTERUS
1
(Gms) %FBW %BRAIN j
0.660 0.2157 33.811 0.817 0.2551 41.599 0.571 0.1832 31.495 0.672 0.2391 33.234 0.818 0.2722 42.560 0.445 0.1536 22.832 0.406 0.1471 21.135 0.487 0.1572 25.645 0.617 0.2313 32.069 0.732 0.2584 36.491
0.623 0.2113 32.087 0.146 0.0474 7.2364
FBW - Final Body Weight
780
DuPont-4739
\^J
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
__________________________________________
INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION
Group : VI - 250 mg/kg/day Sex :FEMALES
I ANIMAL I
OVARIES
I (Gms) %FBW %BRAIN
I 641244 I 641251 I 641269 I 641292 I 641302 I 641362 I 641363 I 641375 I 641379 I 641398
I I Mean
S.D.
0.099 0.0335 5.0900 0.097 0.0365 5.1733 0.090 0.0338 4.6802 0.133 0.0402 6.7274 0.147 0.0489 7.3832 0.130 0.0457 6.5856 0.101 0.0260 4.9461 0.114 0.0321 5.8432 0.123 0.0384 6.4908 0.121 0.0395 6.3185
0.116 0.0375 5.9238 0.018 0.0067 0.9103
SPLEEN (Gms) %FBW %BRAIN
THYMUS (Gms) %FBW %BRAIN
0.529 0.1790 27.198 | 0.445 0.1674 23.733 | 0.529 0.1989 27.509 | 0.581 0.1755 29.388 | 0.548 0.1824 27.524 j 0.506 0.1778 25.633 | 0.651 0.1678 31.881 j 0.682 0.1918 34.956 \ 0.428 0.1337 22.586 j 0.580 0.1894 30.287 |
0.258 0.0873 13.265 0.238 0.0895 12.693 0.274 0.1030 14.249 0.306 0.0924 15.478 0.357 0.1188 17.931 0.255 0.0896 12.918 0.444 0.1145 21.743 0.472 0.1327 24.193 0.339 0.1059 17.889 0.267 0.0872 13.943
0.548 0.1764 28.070 | 0.321 0.1021 16.430 0.080 0.0181 3.7237 j 0.082 0.0158 3.9587
UTERUS (Gms) %FBW %BRAIN
0.583 0.1973 29.974 0.816 0.3069 43.520 0.604 0.2272 31.409 0.462 0.1395 23.369 0.754 0.2510 37.870 0.597 0.2098 30.243 0.727 0.1874 35.602 0.641 0.1803 32.855 0.706 0.2206 37.256 0.602 0.1965 31.436
0.649 0.2116 33.354 0.103 0.0449 5.5029
DuPont-4739
Group : VIII - 1000 mg/kg/day Sex :FEMALES
m
I ANIMAL I
OVARIES
I SPLEEN
I
(Gms) %FBW %BRAIN I(Gas) %FBW %BRAIN (Gms)
THYMUS %FBW %BRAIN
I UTERUS
I
I(Gms) %FBW %BRAIN |
I 641237 I 641275 I 641279 I 641299 I 641300 I 641314 I 641326 I 641327 j 641380 I 641390
I I Mean I S.D.
0.069 0.0293 3.8291 0.128 0.0505 6.5675 0.121 0.0347 6.4706 0.130 0.0532 7.0156 0.141 0.0473 6.3456 0.113 0.0360 5.8098 0.105 0.-0415 5.4461 0.149 0.0401 7.7645 0.146 0.0486 7.3961 0.147 0.0462 7.5423
0.125 0.0428 6.4187 0.025 0.0077 1.1756
0.494 0.2096 27.414 | 0.379 0.1496 19.446 j 0.569 0.1633 30.428 j 0.450 0.1843 24.285 | 0.761 0.2555 34.248 | 0.651 0.2075 33.470 j 0.465 0.1838 24.118 | 0.615 0.1657 32.048 | 0.470 0.1563 23.810 j 0.581 0.1827 29.810 |
0.264 0.1120 14.650 0.286 0.1129 14.674 0.477 0.1369 25.508 0.334 0.1368 18.025 0.396 0.1329 17.822 0.305 0.0972 15.681 0.233 0.0921 12.085 0.395 0.1064 20.584 0.260 0.0865 13.171 0.250. 0.0786 12.827
I 0.544 0.1858 27.908 j 0.320 0.1092 16.503
0.113 0.0316 4.8806 | 0.079 0.0211 4.1282
0.670 0.2843 37.181 | 0.992 0.3916 50.898 j 0.419 0.1202 22.406 | 0.738 0.3022 39.827 j 0.510 0.1712 22.952 j 0.521 0.1661 26.787 j 0.473 0.1870 24.533 | 0.697 0.1878 36.321 | 0.618 0.2055 31.307 j 0.550 0.1730 28.220 j
I 0.619 0.2189 32.043 | 0.167 0.0817 9.0400 [
FBW - Final Body Weight
anfzed. Does not contain tsca CBI
781
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR ONE-MONTH RECOVERY EVALUATION
Group : II - 0 mg/kg/day Sex :FEMALES
| ANIMAL
1
| 641253 1 641266 1 641281 1 641294 1 641325 1 641331 | 641359 j 641364 j 641383 | 641400 11 | Mean | S.D.
FBW BRAIN (Gms) (Gms) %FBW
389.7 336.6 293.3 336.0 314.2 311.1 309.5 322.6 295.5 290.4
1.977 0.5073 1.842 0.5472 1.906 0.6498 2.037 0.6062 1.918 0.6104 1.850 0.5947 1.864 0.6023 1.942 0.6020 2.019 0.6832 1.915 0.6594
319.9 1.927 0.6063 29.5 0.068 0.0518
ADRENAL GLANDS (Gms) %FBW %BRAIN
0.065 0.0167 3.2878 0.058 0.0172 3.1488 0.077 0.0263 4.0399 0.086 0.0256 4.2219 0.067 0.0213 3.4932 0.058 0.0186 3.1351 0.058 0.0187 3.1116 0.072 0.0223 3.7075 0.070 0.0237 3.4671 0.061 0.0210 3.1854
0.067 0.0211 3.4798 0.009 0.0034 0.3950
HEART
KIDNEYS
(Gms) %FBW %BRAIN j (Gms) %FBW %BRAIN
1.251 0.3210 63.278 | 2.730 0.7005 138.09 1.169 0.3473 63.464 | 2.419 0.7187 131.32 1.096 0.3737 57.503 1 2.515 0.8575 131.95 1.277 0.3801 62.690 | 2.541 0.7562 124.74 1.309 0.4166 68.248 | 2.488 0.7919 129.72 1.329 0.4272 71.838 1 2.486 0.7991 134.38 0.987 0.3189 52.951 | 2.463 0.7958 132.14 1.123 0.3481 57.827 | 2.337 0.7244 120.34 1.260 0.4264 62.407 | 2.692 0.9110 133.33 1.012 0.3485 52.846 1 2.295 0.7903 119.84
1.181 0.3708 61.305 | 2.497 0.7845 129.59 0.123 0.0411 6.1350 j 0.137 0.0646 6.0397
DuPont-4739
LIVER (Gms) %FBW %BRAIN
9.714 2.4927 491.35 10.148 3.0149 550.92
9.356 3.1899 490.87 10.798 3.2137 530.09
9.967 3.1722 519.66 7.274 2.3382 393.19 8.587 2.7745 460.68 9.869 3.0592 508.19 9.307 3.1496 460.97 7.817 2.6918 408.20
9.284 2.9097 481.41 1.091 0.3157 51.165
Group : VIII - 1000 mg/kg/day Sex :FEMALES
| ANIMAL
1
641234 641256 641282 641352 641366 641377 641385 641387 641399
FBW |
BRAIN
(Gms) (Gms) %FBW
301.3 288.1 414.9 303.5 310.1 293.4 320.5 301.2 342.2
1.792 0.5948 1.873 0.6501 1.968 0.4743 2.028 0.6682 1.987 0.6408 1.890 0.6442 1.819 0.5676 1.904 0.6321 1.902 0.5558
ADRENAL GLANDS (Gms) %FBW %BRAIN
0.088 0.0292 4.9107 0.062 0.0215 3.3102 0.092 0.0222 4.6748 0.068 0.0224 3.3531 0.076 0.0245 3.8249 0.077 0.0262 4.0741 0.064 0.0200 3.5184 0.060 0.0199 3.1513 0.082 0.0240 4.3113
Mean S.D.
319.5 1.907 0.6031 39.2 0.077 0.0618
0.074 0.0233 3.9032 0.012 0.0030 0.6305
HEART
KIDNEYS
(Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN
1.110 0.3684 61.942 | 1.101 0.3822 58.783 | 1.317 0.3174 66.921 | 1.151 0.3792 56.755 j 1.205 0.3886 60.644 | 1.109 0.3780 58.677 j 1.142 0.3563 62.782 | 1.148 0.3811 60.294 | 1.212 0.3542 63.722 |
2.375 0.7883 132.53 2.369 0.8223 126.48 2.863 0.6900 145.48 2.194 0.7229 108.19 2.885 0.9303 145.19 2.447 0.8340 129.47 2.387 0.7448 131.23 2.227 0.7394 116.96 2.702 0.7896 142.06
1.166 0.3673 61.169 | 2.494 0.7846 130.84 0.069 0.0221 3.0664 j 0.259 0.0720 12.629
LIVER (Gms) %FBW %BRAIN
9.403 3.1208 524.72 9.379 3.2555 500.75 12.117 2.9205 615.70 9.306 3.0662 458.88 10.726 3.4589 539.81 8.708 2.9680 460.74 9.682 3.0209 532.27 9.137 3.0335 479.88 9.895 2.8916 520.24
9.817 3.0818 514.78 1.028 0.1786 48.356
Does not contain TSCA CBI
FBW - Final Body Weight
782
$509npanySanRfzed. Poesnotcontain Ten*
r\
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____ ________________________________
INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR ONE-MONTH RECOVERY EVALUATION
Group : II - 0 mg/kg/day Sex :FEMALES
1 ANIMAL
1
1 641253 1 641266 1 641281 1 641294 j 641325 I 641331 j 641359 1 641364 1 641383 j 641400 j 1 Mean 1 S.D.
OVARIES (Gms) %FBW %BRAIN
0.141 0.0362 7.1320 0.133 0.0395 7.2204 0.110 0.0375 5.7712 0.127 0.0378 6.2347 0.100 0.0318 5.2138 0.085 0.0273 4.5946 0.097 0.0313 5.2039 0.126 0.0391 6.4882 0.093 0.0315 4.6062 0.126 0.0434 6.5796
0.114 0.0355 5.9045 0.019 0.0049 0.9736
SPLEEN (Gms) %FBW %BRAIN
0.570 0.1463 28.832 0.540 0.1604 29.316 0.503 0.1715 26.390 0.555 0.1652 27.246 0.557 0.1773 29.041 0.489 0.1572 26.432 0.404 0.1305 21.674 0.613 0.1900 31.565 0.602 0.2037 29.817 0.516 0.1777 26.945
0.535 0.1680 27.726 0.061 0.0211 2.6981
THYMUS.
| UTERUS
|
(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN |
0.280 0.0719 14.163 | 0.460 0.1180 23.268 0.292 0.0867 15.852 j 0.697 0.2071 37.839 0.219 0.0747 11.490 | 0.634 0.2162 33.263 0.382 0.1137 18.753 | 0.818 0.2435 40.157 0.330 0.1050 17.205 | 0.813 0.2588 42.388 0.211 0.0678 11.405 \ 0.620 0.1993 33.514 0.273 0.0882 14.646 j 0.494 0.1596 26.502 0.306 0.0949 15.757 j 0.658 0.2040 33.883 0.162 0.0548 8.0238 | 0.758 0.2565 37.543 0.249 0.0857 13.003 \ 0.972 0.3347 50.757
0.270 0.0843 14.030 | 0.692 0.2198 35.911 0.063 0.0177 3.1546 | 0.155 0.0591 7.8317
Group : VIII - 1000 mg/kg/day Sex :FEMALES
1 ANIMAL
1 641234 1 641256 1 641282 j 641352 1 641366 j 641377 1 641385 1 641387 1 641399 II 1 Mean j S.D.
OVARIES (Gms) %FBW
0.142 0.0471 7.9241 0.085 0.0295 4.5382 0.177 0.0427 8.9939 0.130 0.0428 6.4103 0.113 0.0364 5.6870 0.136 0.0464 7.1958 0.087 0.0271 4.7828 0.158 0.0525 8.2983 0.146 0.0427 7.6761
0.130 0.0408 0.031 0.0083
SPLEEN (Gms) %FBW %BRAIN
0.497 0.1650 27.734 0.521 0.1808 27.816 0.641 0.1545 32.571 0.489 0.1611 24.112 0.530 0.1709 26.673 0.516 0.1759 27.302 0.427 0.1332 23.474 0.525 0.1743 27.574 0.636 0.1859 33.438
0.531 0.1668 27.855 0.068 0.0159 3.3244
THYMUS
I UTERUS
(Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN
0.234 0.0777 13.058 0.229 0.0795 12.226 0.481 0.1159 24.441 0.233 0.0768 11.489 0.242 0.0780 12.179 0.223 0.0760 11.799 0.283 0.0883 15.558 0.222 0.0737 11.660 0.245 0.0716 12.881
0.473 0.1570 26.395 0.938 0.3256 50.080 0.640 0.1543 32.520 0.491 0.1618 24.211 0.533 0.1719 26.824 0.592 0.2018 31.323 0.738 0.2303 40.572 0.675 0.2241 35.452 0.680 0.1987 35.752
0.266 0.0819 13.921 0.083 0.0136 4.1324
0.640 0.2028 33.681 0.144 0.0541 8.0663
FBW - Final Body Weight
783
DuPont-4739
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
Group : II - 0 mg/kg/day
INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 3-MONTH RECOVERY EVALUATION
Sex :FEMALES
| ANIMAL 1
FBW (Gms) (Gms)
LIVER %FBW
| j
| 641241 | 641285 1 641288 1 641309 | 641394
300.8 326.9 317.5 318.5 342.3
10.718 3.5632 8.303 2.5399
10.830 3.4110 9.555 3.0000 9.523 2.7821
| Mean | S.D.
321.2 15.1
9.786 3.0592 1.034 0.4265
Group : IV - 50 mg/kg/day Sex :FEMALES
| ANIMAL 1
641247 641319 641321 641340 641391
Mean S.D.
FBW (Gms) (Gms)
LIVER %FBW
334.9 314.9 350.6 318.4 326.9
9.668 2.8868 7.923 2.5160 10.479 2.9889 8.266 2.5961 9.135 2.7944
329.1 14.3
9.094 2.7565 1.038 0.1975
1 1
| | | |
1 1 | 1
FBW - Final Body Weight
DuPont-4739
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Genration Reproductive Evaluations
Group : VI - 250 mg/kg/day
INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 3-MONTH RECOVERY EVALUATION
Sex :FEMALES
| ANIMAL 1
| 641232 1 641262 1 641305 1 641372 | 641382 1I | Mean 1 S.D.
FBW (Gms) (Gms)
LIVER %FBW
410.8 374.5 320.4 317.3 305.5
12.055 2.9345 9.519 2.5418
10.094 3.1504 10.064 3.1718
9.058 2.9650
345.7 10.158 2.9527
45.1
1.143 0.2532
| |
Group : VIII - 1000 mg/kg/day Sex :FEMALES
| ANIMAL 1
FBW (Gms) (Gms)
LIVER %FBW
| |
| 641259 1 641264 | 641278 1 641301 j 641395 1
| Mean | S.D.
409.8 381.3 325.9 392.3 349.6
371.8 33.7
11.057 2.6981 11.335 2.9727
9.404 2.8855 10.618 2.7066 12.302 3.5189
10.943 2.9564 1.059 0.3357
FBW - Final Body Weight
DuPont-4739
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
APPENDIX L INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
786
0 ffiP I SM ltked. Does not contain TSCA C i!
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
KEY TO APPENDIX
LESION GRADING:
Histopathological changes are described according to their morphologic character, distribution and severity. The distribution (extent of tissue involvement) is indicated, where appropriate, by modifiers such as focal, multifocal, diffuse, unilateral, bilateral, etc. A severity score, if appropriate, is also assigned as follows:
MINIMAL:
The amount of change present barely exceeds that which is considered to be within normal limits.
MILD:
In general, the lesion is easily identified but of limited severity. The lesion probably does not produce any functional impairment.
MODERATE: The lesion is prominent but there is significant potential for increased severity. Limited tissue or organ dysfunction is possible.
SEVERE:
The degree of change is either as complete as considered possible or great enough in intensity or extent to expect significant tissue or organ dysfunction.
COMMENT :
Grades minimal through severe represent progressive involvement/severity along a continuum with minimal lesions being the least severe and severe lesions being the most severe. While the grades refer to the morphological characteristics of lesions, they also indicate their relative biological significance.
Gross observations listing multiple masses for a tissue are distinguished with letters (i.e., a, b, c, d, etc.).
787
osapamy S a n ite i. Does m l c a p ta i TSCA
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641066
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND : ALTERATION, COLLOID, mild.
No Microscopic Abnormality Observed : NOSE
788 JSsnspany Smftked. Doss not co n fa i ^ C
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641069
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
HEART : CARDIOMYOPATHY, minimal.
PARATHYROID GLANDS : NOT PRESENT.
EYE(S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT.
641069 Continued on the next page ....
789 Dees net certain TSCA CBS
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641069
Continued from previous page
Histopathology :
No Microscopic Abnormality Observed : KIDNEYS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE
641070
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
641070 Continued on the next page ....
790
Company SanBfeed. Dees netconfa! T8CA CB!
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641070
Continued from previous page
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS :
NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. LUNGS :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. PANCREAS :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. PROSTATE :
INFLAMMATION, SUBACUTE/CHRONIC, minimal.
No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE
791
Swpam f Sanitized. Does not contain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641083
Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
No Microscopic Abnormality Observed : LIVER, THYROID GLAND, NOSE
641084
Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed :
LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 641084 Continued on the next page ....
792
Cwnpatv Sanitized. Does not eonfaln TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641084
Continued from previous page
Gross Pathology :
No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
No Microscopic Abnormality Observed : THYROID GLAND, NOSE
641085
Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND,
641085 Continued on the next page ....
793
Company Sanitized, Does not contain TSCA CBi
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641085
Continued from previous page
Gross Pathology :
No Macroscopic Abnormality Observed :
THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS,
PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE,
SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES,
FEMUR/KNEE JOINT, STERNUM, NOSE
'
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND :
ALTERATION, COLLOID, mild.
No Microscopic Abnormality Observed : NOSE
641094
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed :
LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 641094 Continued on the next page ....
794
Sanitized. Does lo t contain 7SCA CBf
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641094
Continued from previous page
Gross Pathology :
No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
KIDNEYS : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
PARATHYROID GLANDS : NOT PRESENT.
BRAIN,
No Microscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA,
SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE
795 W ipsf Sanitized. Does not contain TSCA CBi
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641098
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed :
LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN,
AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM,
ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH
NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS,
ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND,
THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS,
PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE,
SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES,
FEMUR/KNEE JOINT, STERNUM, NOSE
'
Histopathology :
LIVER :
.
INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, mild. THYROID GLAND :
ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
796
eompany Samites. Does oof oooWo tsca cel
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641101
Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
.
INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND :
'
ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
797
0Btpanf Sanitized. Does not confn tqoa CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluating
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641104
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND :
'
ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
Ono.<n.aln TSCA3I
798 Gosnpsnf Sanitized. Does n*t
A^gj
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641105
Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed :
LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN,
AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM,
ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH
NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS,
ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND,
"
THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS,
PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE,
SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES,
FEMUR/KNEE JOINT, STERNUM, NOSE
'
Histopathology
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
799 OBpsnjjfS m iita L Does not contain TSCA CB
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641115
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
800
Company Sanitized. D o b s not contain TSCCfii
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic Sc Macroscopic Findings
641123
Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed :
LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN,
AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM,
ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH
NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS,
ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND,
THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS,
PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE,
SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES,
FEMUR/KNEE JOINT, STERNUM, NOSE
'
Histopathology
LIVER :
.
INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
^
801 osnpanj Sanitized. Does not contain TSCACBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641147
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal.
KIDNEYS :
*
NEPHROPATHY, CHRONIC PROGRESSIVE, minimal.
HEART :
CARDIOMYOPATHY, minimal.
THYROID GLAND :
ALTERATION, COLLOID, minimal.
.
641147 Continued on the next page ....
802
Company Sanitized. Does not contain TSCA CSI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641147
Continued from previous page
Histopathology :
No Microscopic Abnormality Observed :
LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD
STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLOn '
RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR
LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE,
PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS,
PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, PROSTATE',
SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES,
FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE
'
641;L49
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed :
LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN,
AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM,
ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH
NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS,
ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND,
THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS,
PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE,
SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES,
FEMUR/KNEE JOINT, STERNUM, NOSE
'
641149 Continued on the next page ....
803
Sanitized Dees not contain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641149
Continued from previous page
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. KIDNEYS :
NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HEART :
CARDIOMYOPATHY, minimal. PANCREAS :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal. PARATHYROID GLANDS :
NOT PRESENT.
No Microscopic Abnormality Observed . LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE
804
Company Sanitized. Does not contain TSCA CBS
H-24616: Subchronic Toxicity Study p Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641154
Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
805 Cewpafjf Sanitized. Does not contain TSC CBS
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641155
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology
LIVER :
.
INFLAMMATION, SUBACUTE/CHRONIC, minimal. LUNGS :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal. PARATHYROID GLANDS :
NOT PRESENT.
641155 Continued on the next page ....
806 Company Sanitized. Does notcontain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641155
Continued from previous page
Histopathology :
No Microscopic Abnormality Observed : KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE
641159
Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
641159 Continued on the next page ....
807
C&mpastf Sanitized. Does not contain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref 641159
Microscopic & Macroscopic Findings Continued from previous page
Histopathology
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
641165
Terminal Sacrifice Killed on Day .- 122 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
641165 Continued on the next page ..
808
Company Sanitized. Does not
TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641165
Continued from previous page
Histopathology
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
No Microscopic Abnormality Observed : THYROID GLAND, NOSE
641172
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal NECROSIS, FOCAL, minimal. 641172 Continued on the next page ....
.
809 C o m p ly S a n t o * . Dana nnl
TSCA CB,
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641172
Continued from previous page
Histopathology :
LIVER : HYPERPLASIA, BILE DUCT, minimal.
LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
ESOPHAGUS : FIBROSIS, minimal.
EYE(S ) WITH OPTIC NERVE : FOLD/ROSETTE, RETINAL, minimal.
No Microscopic Abnormality Observed : KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, PHARYNX/LARYNX, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE
810
.CompanySanitized. Does n o ten t* -
^
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641206
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal.
KIDNEYS :
'
NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. LUNGS :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART :
CARDIOMYOPATHY, minimal. PANCREAS :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal.
641206 Continued on the next page ....
811
fompanif Hanftto Does not contato TSCA CI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641206
Continued from previous page
Histopathology :
No Microscopic Abnormality Observed : SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE
641214
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
641214 Continued on the next page ....
812
9 p f Sauifeed Does notcontain tsca C8
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641214
Continued from previous page
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART :
CARDIOMYOPATHY, minimal. PANCREAS :
ATROPHY, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE
813
O m pm q SanfttecL Does eontein TSCA CM
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641215
Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
No Microscopic Abnormality Observed : THYROID GLAND, NOSE
814 orapMf Sanitized. Does not contain TSCA CBt
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641220
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
Company Sanitized. Does not contain TSCA CBl
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641222
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
GLANDS,
No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID
641222 Continued on the next page ....
816
Company Sanitized. Does not contain TSCA 081
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : I - 0 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641222
Continued from previous page
Histopathology :
No Microscopic Abnormality Observed : TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE
817
Company Sanitized, Does not contain TSCA C3I
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : III - 50 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641055
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology .-
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal. NOSE :
DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal.
_ 818 Company SanltteeA Doss not contai, TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : III - 50 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
541056
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND : ALTERATION, COLLOID, mild.
NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal.
819
Company Sanitized. Does not contain T S C CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : III - 50 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641059
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology
LIVER :
.
INFLAMMATION, SUBACUTE/CHRONIC, minimal.
FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND :
ALTERATION, COLLOID, mild.
No Microscopic Abnormality Observed : NOSE
820
Company Sanitized. Does not contain TSCA CBf
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group :: III - 50 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641073
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
NOSE :
DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal.
821
Company Sanitized. Does not contato 'TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : III - 50 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641081
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. HYPERPLASIA, BILE DUCT, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal.
THYROID GLAND : ALTERATION, COLLOID, mild.
NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal.
822 Company SanRized. Does not contain TSCA CEI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : H I - 50 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641113
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
LIVER : DISCOLORATION, TAN, MANY, < 2MM DIA.
No Macroscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, moderate. HYPERPLASIA, BILE DUCT, minimal. FATTY CHANGE, PERIPORTAL, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND : ALTERATION, COLLOID, mild.
`
641113 Continued on the next page
823
epan^ Sanitized. Does not contain t$ ca CEI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group :: III - 50 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641113
Continued from previous page
Histopathology
No Microscopic Abnormality Observed : NOSE
641144
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
641144 Continued on the next page ....
824
QompanfSanitised Dees net contain TSCA O
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : III - 50 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641144
Continued from previous page
Histopathology :
NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal.
641146
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal. NOSE :
DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild.
825
wtcontain TSC CB
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : III - 50 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641160
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
826 Does not contain TSCA CBS
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : III - 50 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641178
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
,, 827 S a n ftiie d , D oes n o t c o n ta in TSCA CBS
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : III - 50 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641194
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
No Microscopic Abnormality Observed : THYROID GLAND, NOSE
828 GmsP0V Sanffteed. Does notcertain TSCA CB
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : III - 50 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641198
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, minimal. NECROSIS, FOCAL, minimal.
THYROID GLAND : ALTERATION, COLLOID, mild.
No Microscopic Abnormality Observed : NOSE
829
'Company Sanitized Does not contain TSCA CBf
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : III - 50 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641218
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal.
NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal.
No Microscopic Abnormality Observed : THYROID GLAND
830
osnpany Sanitized. Dees not contain TSCA CBl
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : III - 50 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641224
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, minimal.
NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal.
No Microscopic Abnormality Observed : THYROID GLAND
831
CompanySanitized. Does not contain TSCA CBf
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : III - 50 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641225
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
832
Company Sanitized. Does not contain TSCA CBl
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : V - 250 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641061
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal.
833
Company Sanitized. Does not contain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : V - 250 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641076
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : HYPERTROPHY, HEPATOCELLULAR, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
isW i& i
834
CompanySanitized. Does not contain
a CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : V - 250 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641089
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild.
835
ompany Sanitized. Does not contain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : V - 250 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641102
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : HYPERTROPHY, HEPATOCELLULAR, mild. INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal.
NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild.
836
Wpany Sanitized. Does not conta'r*
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : V - 250 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641134
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild.
THYROID GLAND : ALTERATION, COLLOID, mild.
NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal.
837
CompanySanitized. Doesno!contain TSCA eg!
H-24616: Subchronic Toxicity ^O ^j^y^JS vagejtudyjnR ^t5 with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : V - 250 mg/kg/day Sex: Males
Animal Ref
Microscopic i Macroscopic Findings
641137
Terminal Sacrifice Killed on Day : 91
Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology
LIVER :
HYPERTROPHY, HEPATOCELLULAR, mild. INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. NOSE :
DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal.
838
CompanySanitized. Does not
re ^ qq
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : V - 250 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641141
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, mild.
No Microscopic Abnormality Observed : NOSE
839
Company Sanitized. Does not contain TSCA CB
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : V - 250 mg/kg/day Sex: Males
Animal Ref 641148
Microscopic & Macroscopic Findings
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate.
No Microscopic Abnormality Observed : NOSE
840 Cmpany San,,i2ed- Des notcontain TSCA cat
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : V - 250 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641162
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild.
THYROID GLAND : HYPERTROPHY, FOLLICULAR, minimal. ALTERATION, COLLOID, mild.
NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild.
841
Company Sanitized. Does not contain TSCA C B I
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : V - 250 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641187
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND : ALTERATION, COLLOID, moderate.
No Microscopic Abnormality Observed : NOSE
842
Company Sanltfe!. Dons notcontain TSCACSI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : V - 250 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641190
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild.
THYROID GLAND : ALTERATION, COLLOID, minimal.
NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild.
843
Company Sanftlzed. Does not contain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : V - 250 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641197
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY. HEPATOCELLULAR, mild.
fHTRip_GLND
ALTERATION, SSL L SiB , m in im a l, HYPERTROPHY, FOLLICULAR, minimal. NOSE :
DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild.
844
Company Sanitized. Does not contain TSCA CG
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : V - 250 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641200
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. FATTY CHANGE, MEDIAN CLEFT, mild. FATTY CHANGE, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE :
DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild.
845
Company Sanitized. Does not contain TSCA cei
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : V - 250 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641202
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild.
THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal.
NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild.
846
Company Sanitized. Does not contain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641057
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
847
Company Sanitized. Does not contain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641064
Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal.
THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, mild.
NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal.
848 C o m p an y S anitized. D oes not c o n is fn TSOA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641067
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild.
KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal.
LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
HEART : CARDIOMYOPATHY, minimal.
THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, mild.
641067 Continued on the next page ....
849 Company Sanitized. Does not
CB,
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641067
Continued from previous page
Histopathology
NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild.
No Microscopic Abnormality Observed : SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW
641077
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND,
.
641077 Continued on the next page
850
npany Sanitized. Does not contain TSCA CBl
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641077
Continued from previous page
Gross Pathology :
No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild.
KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal.
HEART : CARDIOMYOPATHY, minimal.
THYROID GLAND : HYPERTROPHY, FOLLICULAR, mild. ALTERATION, COLLOID, mild.
NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal.
No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS,
641077 Continued on the next page ....
851
Company Sanitized. Does not contain TSCA C&
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641077
Continued from previous page
Histopathology :
No Microscopic Abnormality Observed : PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW
641086
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild.
641086 Continued on the next page ....
852
Company Sanitized. Does not contain TSCA CBf
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641086
Continued from previous page
Histopathology :
PANCREAS : ATROPHY, minimal.
PITUITARY GLAND : CYST, minimal.
THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, mild.
PARATHYROID GLANDS : NOT PRESENT.
NOSE :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild.
No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW
853
Company Sanitized. Does not contain TSCACBl
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641092
Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal.
THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal.
No Microscopic Abnormality Observed : NOSE
854
C o n p m * San,tked. Does not contain TSCA CBl
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641095
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. KIDNEYS :
NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. LUNGS :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART :
CARDIOMYOPATHY, minimal. THYROID GLAND :
HYPERTROPHY, FOLLICULAR, mild. ALTERATION, COLLOID, moderate. 641095 Continued on the next page ....
855
ConPanjrSanitized. Does not contain TSCAC B I
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641095
Continued from previous page
Histopathology
NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, moderate.
No Microscopic Abnormality Observed : SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW
641097
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND,
641097 Continued on the next page
856 Con>panjf Sanitized. Does not contain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641097
Continued from previous page
Gross Pathology :
No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild.
KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal.
LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
PANCREAS : ATROPHY, minimal.
THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, mild.
PARATHYROID GLANDS : NOT PRESENT.
NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild.
641097 Continued on the next page ....
857
Company Sanitized. Does not contain (SCa c DI
I
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641097
Continued from previous page
Histopathology :
No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW
641130
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
641130 Continued on the next page ....
858
ComP*ny Sanitized. Does not contain TSCACBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641130
Continued from previous page
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal.
THYROID GLAND : ALTERATION, COLLOID, mild.
No Microscopic Abnormality Observed : NOSE
641132
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
.
641132 Continued on the next page
859
C om pany Sanitized. Does not contain TSCA CBi
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641143
Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE :
DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal.
861
CwmpwBj Sanitized. Does not contain TSCA CBS
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641153
Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND :
HYPERTROPHY, FOLLICULAR, minimal. ALTERATION, COLLOID, moderate.
No Microscopic Abnormality Observed : NOSE
862
Company Sanitized. Does not contain TSCA CBS
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641157
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed :
LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN,
AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM,
ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH
NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS,
.ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND,
THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS,
PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE,
SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES *
FEMUR/KNEE JOINT, STERNUM, NOSE
*
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. KIDNEYS :
NEPHROPATHY, CHRONIC PROGRESSIVE, minimal THYROID GLAND :
HYPERTROPHY, FOLLICULAR, minimal. ALTERATION, COLLOID, moderate. PROSTATE :
INFLAMMATION, SUBACUTE/CHRONIC, minimal NOSE :
INFLAMMATION, SUBACUTE/CHRONIC, minimal 641157 Continued on the next page ....
863
098^ S a n it iz e d . DDooeess nnoott contain TSCACBt
"
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641157
Continued from previous page
Histopathology :
DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild.
SPINAL 641166
No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN,
CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS CECUM
COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS '
mandibular lymph nod e, thymus, adrenal glands, sciatic
NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA
ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE,'SKIN
SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES
FEMUR/KNEE JOINT, STERNUM, BONE MARROW
'
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed :
LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN
AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM*
ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH
NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS
ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND,
*
641166 Continued on the next page ....
864
PnijpSanitized, Does notcontt t? *
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641166
Continued from previous page
Gross Pathology :
No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
GLANDS,
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild.
THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, mild.
ESOPHAGUS : FIBROSIS, minimal.
NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild.
No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID
TRACHEA, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW
865 SanBtaed. 0es net e s is te i
r#
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641167
Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal.
HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal.
HYPERTROPHY, FOLLICULAR, minimal.
NOSE :
.
DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal.
866 esfflpfflf SanRbetf. D ees no? contain TSC CBS
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641169
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, mild. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate.
No Microscopic Abnormality Observed : NOSE
867 SwH!xd. Does not contain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641185
Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR, minimal. ALTERATION, COLLOID, moderate.
No Microscopic Abnormality Observed : NOSE
868 .oaipwf Sanfflzed, Does no! contafn TSCA
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641189
Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, mild.
No Microscopic Abnormality Observed : NOSE
869 Cmpiy Sanitized. Does not contain TSC CB!
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641196
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, mild. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate.
No Microscopic Abnormality Observed : NOSE
870
CwnPassf Sanitized. Does notcontain TSCA c m
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641201
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. FATTY CHANGE, MEDIAN CLEFT, minimal.
LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND : HYPERTROPHY, FOLLICULAR, mild. ALTERATION, COLLOID, severe.
NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION/NEGROSIS, OLFACTORY, EPITHELIUM, moderate.
641201 Continued on the next page ....
871
Sanftfeed. Does no! eonfati!n t SCA o **
I J'
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641201
Continued from previous page
Histopathology :
NOSE :
HYPERPLASIA/HYPERTROPHY, TRANSITIONAL CELL, EPITHELIUM, minimal.
No Microscopic Abnormality Observed : KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW
641203
Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND,
641203 Continued on the next page ....
872
Boss not contain TSCA CBJ
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Microscopic & Macroscopic Findings
641203
Continued from previous page
Gross Pathology :
No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND :
ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal.
No Microscopic Abnormality Observed : NOSE
641205
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed :
LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 641205 Continued on the next page ....
fSk
873
Co* P * F Sanitized. Dees not contain TSCA CBf
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
J INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group ;: VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641205
Continued from previous page
Gross Pathology :
No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : HYPERTROPHY, HEPATOCELLULAR, minimal. FATTY CHANGE, CENTRILOBULAR, mild. FATTY CHANGE, PERIPORTAL, mild.
THYROID GLAND : ALTERATION, COLLOID, severe.
NOSE : ' 1 INFLAMMATION, SUBACUTE/CHRONIC, minimal.
641213
Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
,
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND
641213 Continued on the next page ....
_____ -
"
" 874
_
Company Sanitized. Does not contain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641213
Continued from previous page
Gross Pathology :
No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, severe.
No Microscopic Abnormality Observed : NOSE
641216
Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND,
641216 Continued on the next page ....
875
Coa* l tim a*. Don M eom in 7SCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641216
Continued from previous page
Gross Pathology :
No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal.
THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, mild.
No Microscopic Abnormality Observed : NOSE
641223
Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
TESTES : LARGE, RIGHT.
641223 Continued on the next page ....
876
Company Sanitized. Does not contain TSCA CBS
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641223
Continued from previous page
Gross Pathology :
FEMUR/KNEE
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE,
. SEMINAL VESICLES, URINARY BLADDER, EPIDIDYMIDES,
JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. THYROID GLAND :
ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, mild. PARATHYROID GLANDS : NOT PRESENT. TESTES :
DILATATION, SEMINIFEROUS TUBULES, UNILATERAL, mild NOSE :
DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild.
641223 Continued on the next page ...
877
S anitized. DDooeess nraoaf! ceomintta.tin. TSCA ^ .
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VII - 1000 mg/kg/day Sex: Males
Animal Ref
Microscopic & Macroscopic Findings
641223
Continued from previous page
Histopathology :
ESOPHAGUS, FEMUR/KNEE
No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA,
PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, EPIDIDYMIDES,
JOINT, STERNUM, BONE MARROW
878
0*pif Sanfilzed. Does no! eonlaln t$ca CBf
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641240
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
HEART : CARDIOMYOPATHY, minimal.
No Microscopic Abnormality Observed : KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND,
641240 Continued on the next page ....
879
Sanitized. Doesno! contain TSCA CBf
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641240
Continued from previous page
Histopathology
No Microscopic Abnormality Observed :
PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE
641241
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed :
LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
THYROID GLAND :
ALTERATION, COLLOID, minimal 641241 Continued on the next page ....
880 Sanitized. Does notcontain TSCA C8
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641241
Continued from previous page
Histopathology :
No Microscopic Abnormality Observed : LIVER, NOSE
641245
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
HEART : CARDIOMYOPATHY, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
641245 Continued on the next page ....
881
snpwsfSanitized. Does not contain TSCA CB
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641245
Continued from previous page
Histopathology :
No Microscopic Abnormality Observed : KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE
641249
Accidentally Killed Duration of dosing-days: 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
LUNGS : DISCOLORATION, DARK, DIFFUSE.
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND,
641249 Continued on the next page ...
882 oiflpwty SanffeM , Does not contain
''el
.jiiak
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641249
Continued from previous page
Gross Pathology :
No Macroscopic Abnormality Observed : PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
SPLEEN : PIGMENT INCREASED, mild.
STOMACH : CYST, KERATIN, minimal.
PARATHYROID GLANDS : NOT PRESENT.
No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE
883 B ees not eonfafn TSCA CB
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641253
Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND,
.THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
No Microscopic Abnormality Observed : THYROID GLAND, NOSE
884 Sanitized. B ees not eon!ale TSCA cbi
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641257
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND,
. THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. PANCREAS :
ATROPHY, minimal. PITUITARY GLAND :
NOT PRESENT. PARATHYROID GLANDS :
NOT PRESENT.
641257 Continued on the next page
885
DO0oeesnrtn0?fe@nfata_TSCA. CB|,
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641257
Continued from previous page
Histopathology
No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE
641266
Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
641266 Continued on the next page ...
,
886 Co,"Pany S w !. Does notcontain TSCA CB!
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref 641266
Microscopic & Macroscopic Findings Continued from previous page
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, mild. THYROID GLAND : ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
641281
. Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed :
LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
641281 Continued on the next page ,..
887
e w " P F 8Ffe@d. s n,,.
__
Ooes nof co"*a*n
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641281
Continued from previous page
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
No Microscopic Abnormality Observed : THYROID GLAND, NOSE
641283
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC . Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S} WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal.
641283 Continued on the next page ....
888
wnpasySan* Does no!confabr ca cb|
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641283
Continued from previous page
Histopathology :
No Microscopic Abnormality Observed :
KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE
641285
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed :
LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA,' BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 641285 Continued on the next page
889 eom pany fianfflzed D oes r0? eonW n T c j| CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641285
Continued from previous page
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. NOSE :
INFLAMMATION, SUBACUTE/CHRONIC, minimal.
No Microscopic Abnormality Observed : THYROID GLAND
641288
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
641288 Continued on the next page ...
890
C@ P y S i b d ,, D e e nnooffcooonnthahin. ?se/lC_B f
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group :: II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641288
Continued from previous page
Histopathology
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
No Microscopic Abnormality Observed : THYROID GLAND
641290
Terminal Sacrifice . Killed on Day : 92
Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
.
641290 Continued on the next page .
891
TSC OBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group :: II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641290
Continued from previous page
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS :
NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. PANCREAS :
ATROPHY, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal. EYE(S ) WITH OPTIC NERVE :
.FOLD/ROSETTE, RETINAL, minimal.
SPINAL
No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN,
CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE
892 noSanitized. D ees contain TSCA c m
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641293
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND,
.THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE
893
Company Sanltfesd Doss not contain TSCA CSl
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641294
Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed :
LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, . THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
No Microscopic Abnormality Observed : THYROID GLAND, NOSE
894 Company Sanitized. Does not contain TSCACBS
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641309
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, FAT
Histopathology :
THYROID GLAND : ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : LIVER, NOSE
895
Company Sanitized. Does not contain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641325
Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
.
INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
896
Centpamy Sanitized. Does not contain TSCA CBi
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641331
Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed :
LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, . THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Hivtopathology
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
No Microscopic Abnormality Observed : THYROID GLAND, NOSE
Company
897
Sanitized. Does
not
contain
TSCA
CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641335
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND,
. THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
KIDNEYS : HYDRONEPHROSIS, UNILATERAL, minimal.
PANCREAS : ATROPHY, minimal.
EYE(S) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT.
641335 Continued on the next page ....
898
S w ip e d . Does notcontain TSCA CBt
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641335
Continued from previous page
Histopathology
SPINAL
No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN,
CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE
641344
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
641344 Continued on the next page ...
899 Co8S8PanySanitized, Does notcontain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641344
Continued from previous page
Histopathology
PANCREAS : ATROPHY, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
ESOPHAGUS : FIBROSIS, minimal.
GLANDS,
No Microscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN,
. AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID
TRACHEA, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE
641359
Terminal Sacrifice
Killed on Day : 123
Exposure Group : RECOVERY
Animal is signed off from necropsy
Gross Pathology :
,
LIVER : HERNIA.
641359 Continued on the next page ...
900
Cfflpanf Sanitized. Does no! contain TSCACBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641359
Continued from previous page
Gross Pathology :
No Macroscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
901
Gompasif Sanitized. Does not contain TSCA CBt
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref 641364
Microscopic & Macroscopic Findings
Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
902 IS flip ia f Safiltted, Poes net contain */-laj
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641383
Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND,
. THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
903
i&Bspif Sanitized. Does not contain TSCA r fOl
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641384
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed :
LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE
904
CemspMi' Sanitized. Does not contain TSCA CB
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641394
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARYGLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal. NOSE :
ATROPHY, UNILATERAL, NASAL GLANDS, severe.
905
.CwnpamySsrjffi;z@dLDoes not contain TSCA CBS
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : II - 0 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641400
Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
906
Company Sanitized. Does not contain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : IV - 50 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641247
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
907 Company Sanitized. Does notcontain TSCA81
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : IV - 50 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641260
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
No Microscopic Abnormality Observed : THYROID GLAND, NOSE
908
M tpauf Sanitized. Does net contain TSCA CBJ
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : IV - 50 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641298
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
909
@8npanf Sanitized, Does not contain YSC CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : IV - 50 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641311
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal.
No Microscopic Abnormality Observed : THYROID GLAND, NOSE
910
Company Sanitized. Does not contain TSCA CB1
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : IV - 50 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641312
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
911
Company Sanitized. Does not contain TSC CB
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : IV - 50 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641313
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal. NOSE :
DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal.
912
Company Sanitized Does no! contain ^ S O A O B I
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group :: IV - 50 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641319
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
913 Company Sanitized. Does not contain TSCA CSi
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : IV - 50 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641321
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
THYROID GLAND : ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : LIVER, NOSE
914
Company Sanitized. Does not contain TSC CE
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : IV - 50 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641336
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
No Microscopic Abnormality Observed : THYROID GLAND, NOSE
915 CoMpanfSamSttod, Does notesulato TSCACBi
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : IV - 50 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641340
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
HiStopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
916
S au teed , Does not contain TSCA
H-24616: Subchronic Toxicity jO -D ayJjavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : IV - 50 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641355
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
917 C o m p a q Sanitized. Does not contain T SC CBl
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : IV - 50 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641361
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
No Microscopic Abnormality Observed : THYROID GLAND, NOSE
918 Bipanjf Sanitized. Does not contain TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : IV - 50 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641369
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal. NOSE :
DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal.
919
Company Sanitized. Does not contain TSCA CBf
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : IV - 50 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641391
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
920
Company Sanitized. Does no! contain TSCA CBi
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : IV - 50 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641396
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
No Microscopic Abnormality Observed : THYROID GLAND, NOSE
921 Company- Sanitized. Does not contain t s c a rn j
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VI - 250 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641232
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
922
Cemparif Sanitized, Poes not eontaln TSC CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VI - 250 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641244
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
923
Cwnparq? Santtfeed. Does not eonfaln TSCA CBI
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VI - 250 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641251
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal.
NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal.
924
CwnP F Sanitized. Does not contain TSCA c m
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VI - 250 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641262
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology
THYROID GLAND : ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : LIVER, NOSE
925
nspanf Sanitized. Does not contain TSCA CB!
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VI - 250 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641269
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. NOSE :
INFLAMMATION, SUBACUTE/CHRONIC, mild. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild. HYPERPLASIA/HYPERTROPHY, TRANSITIONAL CELL, EPITHELIUM, minimal.
No Microscopic Abnormality Observed : THYROID GLAND
926
C om paq Sanitized. Does not contain tso a
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VI - 250 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641292
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
927
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dos Group : VI - 250 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641302
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal.
THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal.
No Microscopic Abnormality Observed : NOSE
928
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VI - 250 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641305
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
No Microscopic Abnormality Observed : THYROID GLAND, NOSE
929
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VI - 250 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641362
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal.
THYROID GLAND :
.
ALTERATION, COLLOID, minimal.
NOSE :
DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal.
930
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VI - 250 mg/kg/day Sex: Females
Animal Ref 641363
Microscopic & Macroscopic Findings
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
No Microscopic Abnormality Observed : THYROID GLAND, NOSE
931
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VI - 250 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641372
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
THYROID GLAND : ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : LIVER, NOSE
932
H-24616: Subchronic Toxicity 90-DayGavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VI - 250 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641375
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND :
ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal.
No Microscopic Abnormality Observed : NOSE
933
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VI - 250 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641379
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal.
No Microscopic Abnormality Observed : THYROID GLAND, NOSE
934
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group :: VI - 250 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641382
Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Hitopathology :
LIVER :
INFLAMMATION, SUBACUTE/CHRONIC, minimal.
FATTY CHANGE, FOCAL, mild.
THYROID GLAND :
'.
ALTERATION, COLLOID, minimal.
No Microscopic Abnormality Observed : NOSE
935
H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations
DuPont-4739
INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS
Dose Group : VI - 250 mg/kg/day Sex: Females
Animal Ref
Microscopic & Macroscopic Findings
641398
Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy
Gross Pathology :
No Macroscopic Abnormality Observed :
LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE
Histopathology :
LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal.
NOSE :
DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal.
No Microscopic Abnormality Observed : THYROID GLAND
936
