Document oMD9axgyVExN7jv8YM4oYJyQr
FILE NAME: ZD^D/
DATE: D
DOC#: ^D/
DOCUMENT DESCRIPTION:&/ZZZYZ DZZZWZZ^>
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A;:.cec.~1..'....1.- ~ ()"(!
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. l'' ---- . ....., ),, ...,(. r, '.,.;:.t)-''.
-
. l z t Re!'lol"t - 5-'1-52 ...., ...... vwvv ..,(,1~~.r;t..::;.-~=l !r~)ira ~
,.1.ni.nc;
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' .
" .
.I., I!!'i'RODUCTim:
An eJ."Pcri~:mt haa bcon in prot:;l'"ElS:l e.~ Th~ S.:.ri:'.r.~.c !.c;>.boro.tory !'or so~
to pulrnon~7 ct;~'lCCl' h:. ii:d~strie.1 TI'or~i:c!~ -!lxpo~:::d occup~ticnalJ.y to the
nortre.1 o.ir but undo'.!' c~r:di~dons cf hcusing r.:r.d die"t idar.t5.coJ. .-n.tfi. those:
po:;aible C!l.rlicr on~ot of t'..u::orn in th3 c:yos.:;)d nnir::t!l!J th!l.!l L'1 tl-ie control
group o.s \7cll t'.3 to dct0~r.rI.nc the tob.1 incid:>~tc::'l of.' tu=.o~n oocu..-ring ovor
-- tho er.ti!...; ......
poriod
0f
t!:o
c:cporiJ~fft; ..
r ---- , - - - - - - - - - - - ___..... It ID:.ly be ~oro that the evi<lc':icc o~to.u1ad lev1~cls 110 tondcn:cy
,' L - - -
~-------
tcn':'o.rd:J
o;1
.
---- -
~o.rl:!.ol"'
en::;-:;;
o::
t\XorJ
runonll",, t.J
e:':T )osod.
- -
n-:: i::-:al n
:\.~
coan.. c.ri non T:i th
------------
:.. con~ol c.ni'l!".u.\J.::i.
1)e-veztheJ.c:3S,
~
t:1::rc
c!ooz
nppc-e.r
to
be
n
t1c:id
toward
e.
c;rentor i:.cid.:.:ncc of' ..c".::.:io;,z in th:> o=~po::;ccl
b the co!ltrol a.nit:f.lc.
I ' -- -- -- -- I(;
----------~~~-
is i':'.p:n""t~nt to note,
h:;'.~"<!;\Or,
thr:.t
ct~tist~.co.l
...
c.:!eJ.ysls
or tho
... C.n:i::o.
iI ?:..cntal a."'ld tho control anhmls cr3 no r:;:-cator th~ tiGht bo c:=peo'tcd to
cccur by ch!l.."1.Cc e.lcn~.. Th~ o:>..--peri:r.~nt is not ~c':!:iloteC. t;;.."'ld i t it: ccr.siC.ored
likoly ~hat, if tho rn:;ios of' tt'IT.:Or ir.cic!e1~cc :l't tho r:o=CT. poriod ~hen o.ni=..:-.1~
.._,
. I
- --"' ., .~..,;u-
-,-i""";.'"~..'....;....7.
.
.?.'_~"\~fJO~..
7 ~---,.,
i;
-- ~
.-..
O
? .. ,
.....
----- - - - . tu~~in~ tu:i;:;r-5.ol
...... bu' ' b\.u-' d)~~l"t',JJ
U
_~ . . , ,
~"'""
ll"-'U
-"-''-\' 1'~;."J",f-'""1":C"''l r11,C_...'":"-'
n.L
-l,,
.. Fi1,.Jr:1
le::!!
.,, "' .....
"'""""-'--
G 1~.icr-cn:;:
~.n
le.agth
n
fi;-c-:.i
1,)
:.;o
].0
11
n
" n
II lO ;:;o 20
11
:i
" ~o to 50 It
"" "n EO i;o 100 n
r.
II
r.
n
32.,3
rd
1J
~s .. a
ro .. 1
- -~.3 2 .. 7
SS .. 8
d /.1
0
. ----- I
u. .U:i!r::! l !! ;
S
1 #
r
"~,.;
,,
4'
,,d ~l ..
.:. 'u...;
~~ t.- .';;:.rJ...-,
fv" !
- r ~.....'."..".".,'..~:.+- c.,..J .c.,;..;.,.;...., i--'~1."." ~.....n.. ~..i.o L'c.iz:.e ~ \... " '
--';'1, _r....,.,.
tnr..or ~
oi'
t~l-ou '.;
CO
., (''. ~--
t~d.n .
eoli.-lTJ of" en c.;::
J::~:. .ir.e1.r-!1-C-.r..,~s-
-- ;;n:ri.i 11:~..:1_;z
~~..--
------ . ~::c;::t:.: tl!
!
r-;-r;-'-...
....:,.....,
0 iJ..... Quel>cc bc:::ito:J L:.i.nin3 As:oc. J..:it.. Inti3:'~ Report 5-7-52
asbo::ltos
dust
to
~!\P!'v]:il.:.c:1.tely
the
- ----- ---- - -- - ----- ---- -
lcveJ. 0 the m-:1 ~ of the nd.GJ.c..
The
cc:Ieos of the p~dcllc mo cqui~p~tl nth st.iff '\1:i.rc bi.--ush.::!:J to brcn!<: up the
.kept in opcrn.tion ir'..:J:.c1c tho 8-!oot cubica.1. Gu.;rt l"Ooo for l3 hour::J a <.'!.D.:l,
--------- --------- ,.,, ------ fl..nirulz livo c_-cntim~.omrJ.y ~ the roo:.:i, which iz
...............
'--
vontilat,cd.
------ ---- --------. - ---- - .,._~
trlt'h .fre:sh_G!-CG>J.
.. - - _____ .....
4_ir
r:llcn
-
the
...
..-t"-
ticno Ati.:O:Jphoric
~
- cm::,~J.cs
~o
coD.~tcd
duc"ij dia::;~inuto~.. is not in opo:r~... .
-Jn th<J l'Co~ c,t :re~ ir.tcz.-v~l3
with a Grcc..'1~u1a...S!Jith t..:i.<1.aoi; i~i."lc;~ and <.h':.st r:::ot-T.to ~o.cio bJ tho lieht
-- ---- m.....,i-JJ-.:J-.-on--p-m----t-:tc-l-os
p~~..
-
c:.!'.:iic
-- .
foot
- .
of
r.ir.
Ii1 gcn0:-::.l~ the .fibc:s he.vs
rcpre.:rnr:.tetl ab:J~t 6.. 6 p~l'" cent or the tot;5. cou~t.~ oi-- 531)3 ciJ.1.i..ono Of
------------------------- -------------- -- --- ----- tho
tot,a.J.
n:;,r.!Jer
of
fiiJu;.::; _,
~bout.
ll
- --p-31' cent (!l'C
1..,11cGr
th:.n
20
r0.:i..c!'Ons.
It
m.:u
be
recalled
'c.ha.c,t
in
l.. ~~~xd
to
t:t3
p1'0d1:.ctio11
ol'
-
c.scc::stosis,
t'ho
t!l~ d-..~~'c. :coo:zi; 130 of t!1ccc u-i:i:tc S(,:-~.n C ::ticis, m-.d 1:30 ncro Strai.n C57 b~t:l: r:.ic!}. Of CD.ch !J0rain .30 '7Br~ i:'..::?.lcs a71d 100 licr<1 for1alcn.. This zcx l'-'_tio tia.!3 dict::::.ted b:r sp<l.c~ :..~cquirc::-:mt::;., en.nee Z2.lc cl.co
anin...,,,_q cJ1d control c.:d:-:-:J.z '\'iC!'a kiD.c-cl t-;l; rceuJ.:.>.r intervals c..ftcr tc1G
"?
()
..
becinni.7JC of the c~q;o:rnro to dn~t.
Qu.::b~c ,;--;:.o:; tos ~i.i.nin~~ A:J =ice.
1st L-it~.u1 nopoz-'17. 5-7-52
6 T1.1.".. in~!~!-7~"'1."ab c!..-..-.."..'.". ";;';.i.... .\,1,..;..''re 2 , " ' ' , 10 ,
r-1 RESU!JI'S 'l'hc obDC'.l.'\'2.tions r!!.:.de at ~ch of the pcr-.iodr. r:h'3n ~ni..r:i~l.9 T!'Cl"O ld.D..ctl
C2.!f.n:v.i.tcs. It hn!l bac:1 nzcesoru:y to diac;:.rd tl::i~(; ;.;.n:imaJ.s cor..pJ..ctcly .fro::!
The S.3.WO sit.uation i~: t1~uc ni'th:l.n the SC,r~:i.r~ C57 1>=1.:..l.ck. Obvioi.:::ily, t~io
S.E.
...
. . 1'-#'
. \.:..
5-7-52 -
-- -- - - . -
--~-v - - - - ..
J.nt 1. .J.!rifil f.'.cpc;."t
n n
n
mi::.hoUt tt:r:ior in ihc St.1.."JC specific group
inci<lenco bottior;n t;-10 i:roup3 1~ i:pc.:i.tc!" tha.:.1 twice the s:,;ar:da._'tl error of tha.t difference;. ttc d:..ti'cr er:.cc !.l\~ b..;, c.o!'J!;idc:tc<l to be :Jigni:~ic~t and
Cl."'iticaJ. V\llt'..c c.l brlce the sknc~.n: m...rc~'. of diffc:-ence are co::!~cd fOY
of th8 obnervatim;,s ~.:'.o tc d.it.o ,.re st~.tistic:'1.1~:r sicrij..lic.:mt. An
eJCa!'.!ple o:.: the 7.cthod (If c~.lculai:.:.on rollow~ ~ "\1-
Calc111!ltion of sttmdard errol' of dif.fcrenc~ betr;een o:cr...-211 incicJ.enco
table l; Inc5.donco oi~ tlZ1013: Control mlil~J.s
Control c.ni.~
S.E., .:\i~9. 5:r 900 s.>2:.~~ 91!.~-=- ~4.so ..-.2..s1
~ 119
J.81
2.,77
2 x S.E. ~
~'~1.61
,
{j
. ..Thus a di..ffcrence up to ~5. per cent is like~ to occur b-.f ch~nco. The
obscrvsd difference or 4 per ccr,t (9c5 .... 5.5 = h.9) ocy thcr~foro have
occurred sinply by ch~.ncG distribution of ~ni~.ls .wd is mt stati!'Jcically sigr.d.ri~t ..
It 'u.11 bG .:1:ppari;nt .r."'roo a rcYicw of t~blc 1 that the c:J..;.:.eriwl."'Ilt is n0i'1 in its oost ir.lportc:rt. p!w.!le. Tha :i.ncidence of puloonarJ tu..~ors hc.s
begun to rice fo'!.... a.'1:5.r.:..-..l!J !dJ..lcd c:i:. the lh-~onth pe!'iod, both for the control ~"'limls and for tl1c: anjP-31.'> eApos~<l to a~br-rntos dust. The incrCD.se-..i incidence i~ ::-.ore prcnoun.ced for the ~cup e>-:pos'Z<l to d.1..l!lt., but the ris~
has occmTe<l c.-C. ~bout the sn~m tir'...c i.'1 both f;I'OUps. 11.'hc dif.tcrcnccs bGtv10:.m
cant.
':fno imp!."i~oion iG ~ain~tl from e.11 inspectio:"l of t~blc l tMt the brgt3
1iemcn ~.ml dot1.:i.ct.inG fro:i ~he ~IJ.itudo of tho incidence or tcr:.:1r. It
mu~t. be noi:icd thc.t t1Li.D si:.u.dy hc.s been mi experi::cntal one and th~t it hn.s been 11;:ic0asary to ~<e obs~ations by killil-ie J..'1i4':>1 s for study at rcgu].D.r intervals~ It ~f)pcn.rs tMt by mea.n:J of a rather i.'t'lvolvcd sto.tisti.... Cc.l pl'OCCdUl'e the dir;prop.o:.'tionate r.c:!.r;htin~ of tho ValU~'.3 by the data of
out cft,er ii.n.i3.1 ob5crvutio1....s h.::.vo been l.!2a.do, cincc it is too la.boricus r-..n undert.ald.nz to be pe!'forr.ied ~t C.hs presont ~rt.~e uhe.'l the v~lnoz obtained liould be only of acodc=.Uc i.'l'ltcrcst.
lQsuctbcW. c',rsibrc.lctTo!c:p:oi l.i~.t~n5-.7:,~A52s::wc.
It ~y he noted ~1 ~Si?lG that i tho ovei--all incidence of tUJ!l.or
rather
th:i.n
9 .5
per
cent-the
dif fcrcnce
bct1'rccn
the
'-
incidence
fo!'
the
m..-posccl croup and for ~he control zroup tJOu.ld hav~ been statisticnlly
VI o mr.;.U\.RY
. ./'
..
An e:c-pcril:.cnt concernin;,:; i:.ho inlu.cnca or inhaled asbestos dust upon
the incidence of pt~nnr:r tmors 5.n mico ho.s been in p:-o;:;rc::zs ror 14
month:3. ,\nal~is or th~ results ol.' thi!:i m:pcr:L"lcnt reveal!! that thus 1"u:D
(after the an.:i.l:'.'1.1.3 h~vo been c.AT..OSC\.i to C'.lSb~stos c!.ust for 14 ~nths), the
dust hn..'1 ll')t C::l!lrted ~"1. in.fltencc of a doa:rc-e oui'ficicnt to ce.use stati~-
tically s:tcnii'ic?.nt uJ.terat.ions in the incidence of pu.lnona.r.r tu."'.'.ors. 'l"n~
.i'i.n.:U ph.'.l:.;cs of this cxpa!':ill.cnt vi:i.JJ. oo of r;rent i1:lpo::'tance, since u.t the
oost recent pc1icd '7hon "-.'1.i:r..:i.ls :ere ldlle:~l for stuc.1y the incidence of
tu.r:lors hud incrcaoed v.n<l the ir.crc<.sc oc~'3 to be? ~o:i."o ~onouncccl e.r.:o~ th:)
a.niDal.s cxr..oscd to asb~~tos dust t1~an anon~~ tho non~,..;...-po~ed control rulizr'.li.lc.
AJV:je
~.
TabJ.o 1
. I .r H~ber rJic~ ~h Sticin o! ~d..c~
Pr~ioct of
ol'
n:i..
tUL~Z" :1.n the c;rc1J.p
~itL"i.)cr o clc a "ci. t :-:
t1.1.U0r in the contT"::1:.
Clbom."V'l:?:t:~on
e:r.pc:::;cd to n.sc~to::i
ep.olf.p not c:q-;o:=;cC. 'i.c
du.!rl; cl."t.\!:t .----~~~~~~~-~----~~~~~~~~-~~~--~~~~~~~-;-~~~--~~~~~~
I. Jhln
FH:71.!"J.. G
llal.o
Strtln C
2
0
0
0
l
{Tui:a:> suscou::.~JJlc
l~ .
0
1
0
0
c strui11 of n:r..ca)
6
i~
1.
0
- ).0
0
2
0
1
:11!
1
7
0
J.i.
- - -~~
J.2
7
-~-o-------72-92
Strain C!)? UJ.a,-:.k
2
(Tu::t'.)r non-~t!sceptiblo
h
rrl:.r~in of mico)
6
10
J.h
Incit1.oncc oZ "~1:..~cr:
0
0
0
0
0
0
0
--2
l 2
-5
-1-9 -
66
~5
;; ? 85 r.: :~;>.,c, y.''
0
0
0
0
0
0
0
2
0
l
~3
20
69
ti9
3 ~. 89 t~ 3 Jr,; "
. Incic.!enc~ of t~:..m. in toth g:ou.ps: 17 .: 179 =9S%
10 !. 181 :t: 5.5~
l..-------------------1----------...:.--~-------
-;vt' ;.
Table 2 ...
..-~~~~~~~~~~~----!----
....... -------...,-~--~~~~--~~
~.._~----~~~~~~~
J OrourJD of r.t:l.co
conp:ll'<..~
~~~~~~~~~~---~-
O'cncrvcd clj_f.:.'!!..":."Qr\CC in
i~~cic':cncc
Tr.ice tho f:t~nc!mc.1 i;rror of difi'c::.'c:1c~
~--~--~~~~~--:~~~~~
~r CC'!'rlt
St1..a.in C
,, a!lbe3tos '70U:V
vs
~
-;1 ....
8.8
Strain C
cont1"ol r;i.cu.J?
or S t a t i:;tica.1.
sie;nific~cc
ob~CI"":cd d.i..ff c~enco
Str~ C57 black
ri.sbezto!> i;i:onp
\"S
6.5
Ctr~.in C57 bl(lck
cont.rel ?oup
All r.nbc5to~ c;:ou!XJ
(both .strm.no)
VO
All control ~~cups (both. stra:L"1s)
All ~~lx:~ton croup~
"t 10 an1 14 ~ont[.s
vs
B.3
iUl control groups
o.t 10 and J.4 r:onths
13.0
!L11 o.s'bcst.o::i i;l'OU~S (t.otaJ_ iuciC.cnce)
V:l
All STOi.rpS ~
(total incidc~1cc)
* The VulUCS for alJ. ~).'0'..l'~:c (tot.."\l. incidcnCCT) <":..!'C O~!:~<l Upon Obl2.rV'D.tior.3 for
the asbest.O!l ~r:d Che Control STOU.:_:.~ fillj ~:;o f:C)':' ~OU~ c:q:;-::i.::;:;;d t.o tTIO other dlli:E.~-~.,..on o~icc 2.nc! qu"t.:~o-in ~ot.:~~ c:-.--pc!:i.cont,