Document oDwEO1mvbj9kJQKdx2JowOL8D

AIA-92 OUTLINE OF PROPOSED HOKOORAPK ON ASBESTOSIB Saranac Laboratory .Study under Prant iron Aabeatos ' , PART i HUMAN AS5EST0SI3 1 Human Pathology - a study of 25 autopay aaees, Illustrated 2 X-ray Patterns In Asbestosis, Illuatratad 3 Ash and Mineral Values in Hunan Asbestosls 4 Complications of Asbestosis * (a) Susceptibility to Infection . i Tuberouloua ii Non-Tuberculoue ill Cancer of the lung . 5 Disability, causes end conparlaon with elllcoals 6 Diagnosis . (a) History of adequate exposure (b) X-ray filD pattern (c) Physical examination (d) Asbestosis bodies in sputum, their significance i-X........... 40380174 AIA-92 (2) PART IZ Experimental A*j?Hgflla Z Methods . (a) Inhalation exposure to plant dusta. ' (b) Injeotlon Into lungs through trachea of pure minerals, (o) Injection of pure minerals into other organs. 2 Species Susceptibility Man, guinea pigs, rabolta, oate, white alee and rata, dogs. ' 3 Peculiar Charaoterlatloe of Asbestoela ' (a) Unusual localltalon of chrysotlle fibre in lunga. (b) Rate of resultant tiaeue reaction oore rapid than to ouarts. (o) Reaction to chryeotlle not progressive after exposure ceases; again the reverse of the situation in silleosla. (d) Asbestosle Bodies 1 Conpoaitlon and aathode of foraatlon. il Occurence in different species, ill Foraatlon does not parallel developaent of fibrosis, iv Gradual disappearance after exposure eeassa. 4 Comparative Effects of Different Aabestlfora ainerals. ' (a) Canadian Chryeotlle. (b) Arisons Chryeotlle, low iron. (c) Crooldollte 1 Bolivian speoloen, stiff and elastle. 11 South Afrioan, soft and flexible. (d) Anthophylllte (e) Anoalte. . (f) Trenollte. . . 5 Effeote of Control Minerals . . (a) Orannular Serpentine, sane ohenlcal composition as . chryeotlle. . . (b) Olass Wool, a synthetic silicate fibre. (o) Bruoite, a fibrous magnesium hydroxide almost free of silica . . 6 Chemical Composition of Asbestlforn minerals in Relation to Irritation. . (a) nothing in composition correlated with relative lrrltatlr. capacity. ' (b) Preliminary acid treatment . 1 Hydroohlorle sold 11 Carbonic acid ' 40380175  (3) Cc) Effeots of Alualnua 7 Phyaioal Properties in Relation to Irritation (a) Length of fibre (b) Effaot of Crushing (q) Heat treataent 8 Mature and Slgnlfloance of Aabeetoela Body (a) Formation (b) Protective effeot preventing further Irritation (o) Ultiaate aolubllity in tisaue 9 Theories of Action of Aabaetifora Minerals (a) Chealeal - reasons for considering invalid (b) Meohanioal - experimental deoonstratlon of. ' 10 Coaplleatlons - (a) Infection, tuberculosis and other varieties (b) Cancer of lung - experimental data suggestive but not proven . . 11 Disability 12 Essential Features of Katardous Exposure (a) Mature of dust - flbroua component and size factors (b) Atmospheric Concentrations - probably lover than for quartz . 1 Inadequacy of standard lmplnger sampling method ` which does not oolleet the dangerous fibres 11 Eleotrostatlc preclpltata<sampllng preferable but . method must be modified (c)'Duration of Exposure 12 Recommendations for a New Standard of Safe Atmospheric Con . centratione of Asbestos Dust . (a) The Quasi-official standard-of 4 to S million particles per cu. ft. (b) Work upon better method of sampling . (c) necessity for oomparlaon of results with X-ray findings in employees 14 Prevention (a) Chemical means not practical ir I U) . | 1 Acl&osia necessary to dissolve fibre in lungs worst ' than Aabeatoaia - 11 Aluminum Therapy Inapplicable ill Chief reliance still upon dust prevention with ' / special snphasla upon the fibrous components ' AIA-92 40380177