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-f LIVER AN3IOSAR0DMA CASES OTFIDENriAL WFX/ASL - ASL AEDRESS CIRCXIMnCN OF REGISTER ADAMS Dr A Ross Air Products, Allentown, Pa, USA BAGSHAW Dr I M M Norsk Hydro, Newton Aycliffe, UK BAND Dr P R Cancer Control Agency of British Columbia, Vancouver, Canada BARNES Jnr W C Monsanto, St Louis, Missouri, USA BARR Dr J T Air Products, Allentown, Pa, USA BARRAT Dr G AECRP, Conmentry, France BARTER Dr Peter EMAS, London, IK BEAUPRE M Govemnent of Quebec Cancer Registry, Canada BENEO! Dr M Naphtachtmie, Lavera, France BENNETT Dr B ICI Hlllbouse, UK BERTAZZI Dr P BESCHE Dr Inst of Occupational Health, Milan University, Italy Dynanlt Nobel, Troisdorf, Germany RECEIVED BISHOP Dr C BORRELLI F E EMAS, Bootle, IK Georgia Gulf, Delaware City, USA MAR 6 1986 BOYER R W Formosa Plastics, Delaware City, USA BURGESS Mr David ICI Americas, Wilmington, Delaware USA R.W. FRASE EYREN Dr David Kemanord, Stockholm, Sweden CARTER Dr J T EMAS, London, IK CELLA Mr C Enichem Polimerl, Milan, Italy CHANCE Mr M ICI Runcorn, U^. CLAUS Mr p G APME, Brussels, Belgium CLAYTON Mr H Norsk Hydro, Newtcn Aycliffe, UK CDNTASSOT Dr J C Chloe (himie, Saint-Fons, France DAVIES Mr J G ICI, Everberg, Belglun (2) DE SLOOVER Dr Solvay & Cle, Brussels, Belglun DE VOS Mr A J ICI Everberg, Belglun DIETZ Dr H W B F Goodrich, Akron, Ohio, USA DOLL Sir Richard Imperial Cancer Research Fund, Oxford University, IK DOMERDWSKL S L Dow Chemical, Midland, Michigan, USA DUPONT Mr G APME, Brussels, Belgium FUMDGER Mr H VKE, Frankfurt, Germany ERNST Dr W Berufsgenossenschaft der Chemischen Industries, Numberg, Germany FALK, Dr H Chronic Diseases Div, US Dept of Health & Hunan Services, Atlanta, USA FERGUSON Dr D M ICI Americas, Wilmington, Delaware, USA FORMAN Dr D Imperial Cancer Research Fund, Oxford University, IK FRASE R W DiversiTech General, Akrcn, Ohio, USA FRIEDEL Dr H P Berufsgenossenschaft der Chemischen Industries, Heidelberg, Germany GOLBERG Prof L Duke Univ Medical Center, Durham, North Carplina, USA GOSZTCNYI Jnr Dr R E Tenneco Chemicals, Piscatsway, New Jersey, USA OOTTESMAN R T The Vinyl Institute, New York, USA HARRIS Dr W D Uniroyal Inc, Middlebury, Connecticut, USA HILL Dr G B Alberta Cancer Board, Edmonton, Canada HULMAN Dr D W Diamond Shamrock Corp, Dallas, Texas, USA HMDERER Dr R K BF Goodrich, Cleveland, Ohio, USA HXGSCN Mr J EMAS, Bootle, IK HOGG Dr W A Imperial Oil Ltd, Sarnia, Ontario, Canada KVARD Dr J K University of Otago School of Medicine, Wellington, New Zealand HUMPHRY Dr N F ICI Australia, Melbourne, Australia JAUVEKT Mr J Chloe Chlmie, Paris, France JERVIS Mr H R ICI Mtllbank, London UK KAKHH Dr Bruce Dupont, Wilmington, Delaware USA KREUGER Dr R A BF Goodrich, Akron, Ohio, USA IALOINE Dr J P Solvay, Brussels, Belgium LANHAM Dr John Dow Chemical Europe, Horgen, Switzerland LAWRENCE Mr J SPI, New York, USA lawrence-jones Sir Christopher, Chief Medical Officer, ICI, London UK IKE Dr F I Victoria Hospital, Blackpool, Lancs, IK USLBAOi Prof IK University of Bonn, West Germany IEVEQUE Dr G CDF Chlmie, AZF, Bully-les-Mines, France LEVISCN Dr D A St Bartholomew's Hospital, London, UK LEWIS Dr P Chemical Industries Association, London, UK lOUVIER Mr Solvay, Brussels, Belgium LUSSATO Dr J Atochan, France GENC 007932 -2- WPX/ASL - ASL ADDRESS,2 MATTI ART) Dr J M Medizinsche Abteilung, Luzem, Switzerland MALHOTRA Anna Statistics Canada, Ottawa MALTONI Prof C Institute di Oncologia, Bologna, Italy MATIRE Prof Lo Medil-Anic-S, Milan, Italy MATTIUSSI Dr R Montedison, Milan, Italy MIDDLETON D Norsk Hydro, Newton Aycliffe, UK M3KKA Mr Neste Oy, Espoo, Finland MDNTESANO Dr R IARC, Lyons, France MOTH Dr A A Duperial SAIC, Buenos Aires, Argentina MUNN Dr A Montanto, Brussels, Eelgiun MUNOZ MXJICN Dr M Rio Rodano, Madrid, Spain MacSWEEN Prof RNM Western Infirmary, Glasgow, Scotland NAKAMJRA S Japanese FVC Association, Tokyo O'SULLIVAN Dr JJ ICI Runcorn, UK OLSCN H G VC Safety Association, Louisiana, USA OWEN Dr R Trades Union Congress, London, UK PADDLE Dr G M ICI Central Medical Group, Alderley Park, IK PAGLIALDNGA Dr S t-bntedison, Milan, Italy POPPER Dr Hans Mount Sinai Medical Center, New York, USA POSSEERG Dr J Whcker-Chemie, Munich, Germany HJECH Dr A M Atochem, Brignoud, France PURDHAM Dr J Canadian Centre for Occupational Health & Safety, Hamilton, Canada RAMRAUD Dr J RP Rechetches, Antony, France RAMTNES P Norsk Hydro, Porsgrunn, Norway RICHARD Dr P Rhone Poulenc, Roussillon, France ROBSON Mrs D Saskatchewan Cancer Foundation, Regina, Canada RODRIGUES Dr MJF ICI, Sao Paulo, Brazil ROUSH Dr G Monsanto, St Louis, Missouri, USA RUTY Dr J Atochem, St Auban, France SAIG Dr J NIOSH, Cincinnati, USA SARAOCI Dr R IARC, Lyons, France SCHEFFERS Dr M L DSM/CVMD, Geleen, Holland SCHIPPER Dr H University of Manitoba, Winnipeg, Canada SERONNE Dr D Diamond Shamrock, Dallas, USA SHAH Dr Has CMA, Washington DC, USA SIGEIST Dr J Shell Chimie, Berre L'Etang, France SMITH Dr E Division of Envirormental Health, World Health Organisation, Geneva, Switzerland SMITH Dr P M Llandough Hospital, Penarth, UK SPIRIAS Dr R NCI/NIH, Bethesda, Maryland, USA STAFFORD Dr J Somerset, UK STAHNECKER Mr BASF, Ludwigshafen, Germany v. TAMBURRO Prof CH University of Louisville, USA TER HAAR Dr Gary Ethyl Corporation, Baton Rouge, Louisiana, USA TEKWIES&I Dr B Chercdsche Werke HllLs, Kreis Recklinghausen, Germany THERIAULT Dr Gilles MtGill University, Montreal, Canada THIESS Prof Dr AM BASF, Ludwigshhafen, Germany UUIS-EVENSON Dr E Norsk Hydro, Porsgrunn, Norway THOMPSON Dr D H Cancer Treatment & Research Foundation, Halifax, Nova Scotia, ranaHa ICRDOIR Dr W Shell, An Den Haag, Holland VAN DER MERWE Dr H J AECI, Sasolburg, South Africa WALLACE J R Esso, Sarnia, Ontario, Canada WALIEMATE H BF Goodrich, Cleveland, Ohio, Usa WEJDUNG S 0 Kemanord, Stockholm, Sweden WHEELER Dr D J ICI HiTThouse, UK WHEELER R N Union Carbide, South Charleston, USA WHISTON Dr J ICT Hillhouse, UK WHITE K H Duperial, Buenos Aires, Argentina WILINSKI 0 Electrochemical Industries, Acte, Israel WILLIAIE Dr DMJ BP Chemicals, Penarth, UK WILSON Prof R Harvard University, Cartridge, Massachusetts, USA WRIGHT Dr A P ICI Wilton, UK YORK J ICI Everberg, Belgiun From: Dr B Bennett, Medical Department, Imperial Chemical Industries Pic Hillhouse Site, PO Box 4, Thornton-Cleveleys, Blackpool FY5 4QD, UK. February 1986 CONFIDENTIAL REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVER DUE TO EXPOSURE TO VINYL CHLORIDE - REVIEW DATE 1 JANUARY 1986 PREFACE : Acknowledgments, significant changes and comments 1. The new cases in the Register are the following : France Germany UK 18 23, 24, 11, 12 25, 26,27 2. There are amendments from the previous Register against the following cases:- Germany 21, 22 US 36, 38 3. I would like to thank Dr De Sloover, Dr D M J Williams and Dr Friedel for informing me of new cases. 4. For thecase corrections I wouldlike to thank DrFriedel, MrJ T Barr and Mr R W Frase. 5. For othercorrections andinformation, thanks to Dr D Forman, Mr J T Barr, Mr T H Sutherland and Mr N F Humphry. 6. I should he very grateful if all recipients of the Register could continue to keep me fully informed of any new cases, or, if they should hear of other Companies who have acquired a case of ASL, it would he much appreciated if I could he notified by the appropriate person. It is extremely helpful if new information is supplied in tabulated form, using the headings in the Register as far as possible. 7. I would like to thank the many people who have suggested research topics, and should be grateful if I could be kept up to date. 8. I shall be happy to supply to any recipient of the Register a copy of the Paper "Exposure to Vinyl Chloride and Angiosarcoma of the Liver: a report of the Register of cases" by Dr David Forman, myself, Dr John Stafford and Sir Richard Doll, published in the British Journal of Industrial Medicine, November 1985 (42: 750-753) Dr Brian Bennett Medical Department Imperial Chemical Industries pic Ilillhouse Site P 0 Box 4 Thornton-Cleveleys Blackpool FY5 4QD England February 1986 Index Table Sequence Belgium Canada Czechoslovakia France Germany Italy Japan Norway Sweden UK USA Yugoslavia Incidence of Cases per annum (Table l) Distribution of Cases by Country (Table 2) Pattern of Cases by Factory (Table 3) Latency Periods (Table 4A) Distribution of Latency Periods (Table 4B-4H) Annual Geographical Incidence (Table 5) IMPERIAL CHEMICAL INDUSTRIES PLC LIVER ANGIOSARCOMA CASES (REVIEW DATE - L JANUARY 1966) WPX/ASL_2 - LANGI0CASES.4 Page 1 2-3 4 5-8 9-14 15 16 17 18 19-21 22-28 29 30 31 , ASL Case Numbers by year of Death (Table 6) ASL Case Numbers by year of first exposure (Table 7) Western Europe PVC Producers - Start-up Dates vs ASL Cases (Table 8) USA PVC Producers - Start-up Dates vs ASL Cases (Table 9) Canadian PVC Producers - Start-up Dates vs ASL Cases (Table 10) East European PVC Producers - Start-up Dates vs ASL Cases (Table 11) Japanese PVC Producers - Start-up Dates vs ASL Cases (Table 12) South A Central American PVC Producers - Start-Up Dates (Table 13) Australasian PVC Producers - Start-up Dates (Table 14) Page 42 43 44 45+46 47 48 49 50 51 32 33 34-40 41 4 GENC GQ??05 iPage 1 I i&ELCIUM IMPERIAL CHEMICAL INOUSTRIES t'LC LIVER Angiosarcoma Cases ~ (Review Date ( l January L986) HPX/ASLJ - LANC10CA$ES,6 2 3 4 56 7a 9 10 1 L U 13 14 15 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DTACHOSTS YEARS OF EXPOSURE DATE OF DEATE1 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUFATLON OTHER CAREER HIGHLIGHTS OTHER COMMENTS BELGIUM 01 . 12.01,13 Solvay Jeaeppe 00.07.58 00.05.76 63 16 17 29.06.76 Tea High Autocleaner Driller In a Hepatic testa 14 yra foundry in Oct 1974 195S-L968 (2 yra) were normal. exposed Co Polyworker Farmer Retired 200 ppm 3 yea (15 yra) Feb 1975 for 8 hra Work in glaaa Hospitalised per day Ind. & chemi Hay 1976 and cal industry certainly Complete under Clinical and 500 ppm career details in 6 to 9 b3 are given In a paper by autoclaves Hublet et al 1968-1$ 72 In Arch. Belg. exposed to Had. Sac. , 50-200 ppo llyg. Med, 8 lira per Trsv. Med. day In 2 5b3 Leg. 1977 pages autoclaves 601-622 1972-1974 expoaed to 50-200 ppm In auto clave rooa 1974-100 pis 1975- 50 ppo RETIRED 1 Feb 1975 02 SR 29 09 40 Solvay Jeaeppe 20 00 62 00.10,79 39 17 9 23 10 S3 Yea 08.62-03. 63 Ot.67 -10.71 * 200 ppo Sli/day 04.63-12. 66 * 200 PI* Aucocleaner Fireman since 5 yra 5 ntha 10 71. Operator 3 yra 9mths. 1st alga July 79i Thoracic pain 07. 79. Hepatic teats altered 10.79. Positive echography 11.79. Ilepatectooy 02.80. Chemotherapy. Information given in letter 12 Nov 1984 from Dr Oe Sloovcr. C&vr 00 6 Page 2 CANADA Sheet 1 IMPERIAL CHEMICAL INDUSTRIES Pl.C LIVER AngIoearcoma Cases - (Review Date: l Jan 1936) All dates use UK system DAY " MONTH - YEAR WFX/ASL_2 - LANCIOCASES,7 2 3 A 56 7 6 9 10 11 12 13 14 15 16 COUNTRY AND REFERENCE NO NAME OK INITIALS DATE OP BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OP DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIACNOSIS YEARS OP EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER NIC HU CUTS OTHER COHHENTS CANADA 01 SHAWI 41 GAN 15.12.13 1944 1955 41 u 1 l 02.09.55 Yea Reactor cleaner Operator Smoker polymerisation 02 06.03.14 1943 1957 43 14 14 21.12.57 Yea Maintenance, Operator millwright, plpefjctar Worked overtime Smoker 03 26.06.19 04 05.04.19 05 07.05. 11 06 15.12.19 07 09.11.19 06 13.05.20 09 19.07.21 1941 V962 42 21 20 23.03.62 Yes 1945 1967 46 22 22 21.01.66 Yea 1944 1968 57 24 05 05.07.68 Yea 1947 1971 51 24 23 10.04.71 Yea 194 6 1972 53 26 25 24.12.72 Yea 1961 1973 53 12 05 12.06.73 Yea 1946 1974 53 23 26 04.09.74 Yes Operator, foreman Worked overtime Non" smoker Reactor cleaner Operator, foreman, water cooling unit Wo rked overtime Smoker Reactor cleaner Reactor cleaner Reactor cleaner Water cooling unit Worked overtime Smoker Maintenance, millwright Worked overtime Smoker * Machine ahop operator and poly unit Worked overtime Smoker Reactor cleaner Maintenance machine shop In plant 25 yrel Smoker Furnace op. pipefitter maintenance Worked overtlue Smoker * Paper by Dr F DELORME In Anna lea d'Atm Louie palhologlque Peris, 1970 Vol 23 No 2 p|>l 05 -1 14 clulma Oils caee bad both a hepatoma and ASL a Imultaneoualy GENC 00??Q7 Page 3 CANADA Sheet 2 1 2 34 IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Angloaa rcotna Cases - (Review Dace: 1 Jan 1986) DAY - MONTH - TEAR All datea use UK ayatea UPX/ASLJ2 - LANCIOCASES,B 56 7 8 9 10 11 12 13 14 15 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIACNOSIS YEARS OF EXPOSURE TO DIACNOSIS YEARS OF EXPOSURE DATE OF DEATJ! HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGH LI CUTS OTHER CONNECTS CANADA 10 16.05.15 1953 1976 61 23 14 00.04.77 Yea Reactor cleaner Furnace op. a lute nance, packaging Ex-Backer ' Page 4 CZECHOSLOVAKIA IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Angiosarcona Cases - (Review Datei I Jan ft6) WFX/aSL__2 - LANCIOCASES, 9 2 3 4 56 76 9 10 11 12 13 14 15 COUNTRY AND REFERENCE HO NAME OR INITIALS DATE OP BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OP DEATH 111STO LOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS CZECHOSLOVAKIA OL 26,06,28 State Co Novaky 0L.07.57 24.12.73 45 16 16 24.12.73 Yea Autoclave Cl eaner IARC letter of 1-4-62 giving details from Prof A David of Centre lnd Hygiene and Occ diseases. 02 06,07,27 State Co Movaky 01.11,50 27,11.64 37 14 15 26.11.64 Yes Autoclave Cleaner IAKC letter of 1-4-02 gave sonewhat altered dates for this case. I have accepted the changes since the dates coue froa Prof A David of the Centre of Induutrlal Hygiene and Occupational Diseases. My dates coi*u originally fros NIOSH. Page 5 FRANCE Sheet 1 IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Angloaarcowa Caaea - (Review Date* 1 Jan 86) WPXMSL_2 - LANG10CASES, 10 2 3 4 56 7 8 9 10 11 12 13 14 15 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS FRANCE 01 H 15.04*24 R P Roues- 00.01.46 18.02.67 43 21 19 19.02.67 Yes High Autoclave i 1 loti worker and cleaner 19 yra Ref. Ravler ec al Arch. Hal. Prof. 1 30 3 Nov 75 p 171-177 02 SIM 03.06.11 PCUK Brlgnoud 06.07.59 IS.01.75 63 16 12 24.01.75 Yea Nigh 2 yra on Italian Ref, (NIOSIl no monomer origin G Bonne ton ec consent) 10 yra on al 'Nouvelle polymer- preeae laatlon edical e 5 Nov 1977 p 735 03 WAV 06.01.20 RP St Ferns 00.00.46 15.01.75 55 29 29 29,06.75 Yea High Polyworker VCM production Ref. Kety et 10 yra aa 1 6 yra al Arch, Ma1 autoclave Italian POU Prof. 1 37 n' cleaner Shepherd, 6 June 77 Conpoundlng Sawyer, Maaon p 551-555 - 3 yra 04 M0R 27.01.27 PCUK Brlgnoud 19.10.49 16.01,76 49 26 26 04.01.76 Yea High Mononer production worker 8 yra PVC ftltrat Ion 1 8 yra OS S 29.01.3S EC UK BrIgnouJ 1 8.01.65 13.05.76 3fl 11 11 13.05.76 Yea High Polyworker 11 yra 1 )Thoracotoiay Ref, P Coudere 9th Feb 1976 et el `Seaalne coatal dee hoepltaux angloearcoaa 10 Septcmbre 2 jSclntlgrapliy 1976 found ASL Prevloualy had 3)Haemorrhage bone from ASL angiosarcoma 4)Righc Alao llopatectoay Plllchowekl et a) La Nouv elLe Preeae Medicare 7th July 1979 1 Page 2485 | GENC 007990 Page 6 PRANCE Sheet 2 IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Angiosarcoma Cases - (Review Date! I Jan 1966) UPX/ASL_2 - LANG10CASES, 11 > 2 3 4 56 7 6 9 10 n 12 13 14 15 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH H1STOLOC1CAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS FRANCE 06 Pa 14.04.34 PCUK Brlgnoud 01.03.56 12.06.76 42 16 13 11.09.76 Yea Hoderate (1956-1960) (NLOSil 2 yrs says filtration 12.09.76) LO-ll yrs polyworker and works lab? This man had AOL prior to AS. Ann. de Mai. Prof. July '77 p 645 A 6. AOL was found In 197) five yrs before ASL 07 Cl E 26.04.27 RP St Auban 01,07.50 Af ter 49 26 22 02.07.76 Yea High Plant fore- 1972-6 admin Died of death (NIOSH no ' asn in section In septicaenla HTOSII comment) polymer St Auban Small liver says isation Lesion found 00.07.76 after autopsy 06 B 01.04.34 Solve/ Ta vault 23.05.57 03.12.75 42 19 19 30.01.77 Yes Moderate 6 yrs packer & autoclave clnr 14 yrs autoclave worker Had been tunnel worker previously 09 RPX 09,10.14 RP St Foils 10,01.46 26.04.76 63 36 26 25.12,77 Yes Very High Polymer 10 yrs In Operated 4.76 194 6-1966 isation sulphuric for removal of Lesser ope rator, acid factory, tumour from Exposure autocleaner, storekeeper & llver and 1966-1976 autoclave general maintenance services died after second surgical operation for bll io bronchial f 1 stula Paper by Dr Rely ul u) In Archives He Ma1ades Professionals Vol 40 No 6 1979 pages 741-3. Page 7 FRANCE Sheet 3 IMPERIAL CHEMICAL INM1STHIKS l*LC LIVER Angloaarcoua Cases - (Review Dace: 1 Jsu 1986) WPX/ASL_2 - LANCIOCASES,12 2 3 4 56 7 a 9 10 11 12 11 14 15 16 COUNTRY AND REFERENCE NO NAME OH INITIALS DATE OP BIRTH COMPANY PACTORY FIRST VC EXPOSURE DATE OP DIAGNOSIS AGE AT DIAGNOSIS YEAflS OP EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS France 10 VP 24.05.19 RP St Pone 00.12.56 10.01.70 58 11 L 15.02.12 RP St Pone 00.01.41 12.08,78 66 21 37 - 12 16.08.14 PCUK Brlgnoud 09.02.49 00.05.79 65 30 n 19.01.31 Solvay Tsvaux 23.09.61 26.06,79 40 16 n HJ 05-04-24 Chloe ChluLe (Formerly RP) St POflS 1941 00.07.81 57 38 21 10.01.78 Yea 31 13. IL. 78 Yea 2> 23.06,79 Yea 13 22.08.79 Yee 36 29.07.81 Yea High High Autoclave cleaner 10 yra in mechanical engineering Industry 1946-1956 1941-1946 polymer- leatlon general purpose worker 1946-1972 VCH synthesis (MCI 4 Acetylene) Foreaan (agent de maltrlae) 1972 retired Died of pulmonary embolism 5 days after surgery High Monomer production and polymer isation nperator Autocleaner 2 yra, Auto operator 9 yra, Copolymers 4 yra 2 yra as cycle Cigarette mechanic. smoker until 10 yra as 1974. Ill all enaaeller In of 1977 due to sanitary ware Oesophageal manufacture varices. Surglcal intervene Ion 25.05.79 Very High 1943-1975 1975-1979 1943-1975 Ail types of maintenance and Jobs on work lateraltt- manufacture ently A maintenance (right tiena tecinmy) 1975-1979 in VCH Poly Protean GENC 007992 Pag* F RANCE Sheet 4 ihukrul chemical industries I'LC LIVER Angiosarcoma Cases - (Review Dace: l Jan 1996) WPX/ASL__2 - LANCIOCASE S ,13 t 2 3 4 56 7 8 9 10 11 12 13 14 15 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIACNOSIS ACE AT DIACNOSIS YEARS OF EXPOSURE TO DIACNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOCICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HICHLIOHTS OTHER COMMENTS France 15 HEP 03.01,37 Chios SC Feme 07.07.55 28.09.82 45 27 27 Al Ive Yea High-20 yr Autoclave Chin! e Moderate cleaner {formerly 7 yri 1955-1962 RP) autocLave operator 1962-1982 J C Contaaaot Letter of 5 10 1983 16 OIK 13.07.22 Chios St Fon* 17.10.4L 05.01.83 61 4L 38 03.04.83 Yes High-33 yra Polyaerleat- Chimie Moderate- lon Proceaa (PoraerLy Low - 5 yra Mao RP) Maintenance Worker Health 6 Safety Agent Retired Jan 1979. J C Contasaot Letter* of 5 10 1983 and 25 7 84. 17 HAK 22.02.23 Chloe SC Tons 17.06.48 03.04.83 60 34 28 03.04.03 Yea High - Autoclave Other aectora Re tired Chimie 23 yra Cleaner of St Fun a 01.01.79 (Pornerly 194 8-1971 Factory 197J- J C Coutaeaot RP) 1978 Letter of 5 10 19 83 18 K 14.07.42 Solvay Tavaux 09.09.63 21.03.84 42 21 21 27.12.64 21.03.84 Hlgh-12 yra Autoclave Low - 9 yra Cleener 09.03.84 Right Hepa tectony 05.05.8424.09.84 cheactherapy for lungnetastasls ; partial reaiauloo. 08.64 - liver recurrence. 10.84 - lung: evolution of the disease Page 9 GERMANY Sheet 1 IMPERIAL CHEMICAL INDUSTRIES Pl.C LIVER Angiosarcoma Cases - (Review Dale; l Jan 1986) WPX/ASL_2 - LANG10CASE S.14 2 3 4 56 7 8 9 10 11 12 13 14 15 COUNTRY AND REFERENCE NO NAME OK INITIALS DATE OF BTRTII COMPANY FACTORY FIRST VC EXPOSURE DATE OF diagnosis AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS GERMANY 01 02 00.00,30 Dynsalt Troiedorf 01.10.36 19.09.6B 38 12 12 25.01.69 Yea (NIOSli) 00.00.31 Dynamlt Troiedorf 14,10.57 25.09.70 39 13 1L 14.12.71 re. (NIOSli) Polyworker Poly worker 01 00.00.30 Dynamic Rhelnfel- 09.06.52 00.03.73 43 21 16 10.10.73 Yea (NIOSli) Filling Reported under den pesticide non polymer aerosol cans isation ul tli VC workers in NIOSH Hat of 31.3.77. This of course la strictly correct. However l wonder whether this man bad high exposure to VCH in hla can filling ope ration? 04 00.00.30 Uacker btirg- 16.04.57 2 6.11.74 44 17 17 25. 11.74 Yea (NIOSli) 200-500 ppm Polyworker 4 1958 was Clinical hsueen but high temporary autocleaner Jecalls In during 1 yr autocleaner for 1 yr paper by autocleaner Cokel et al Virchows Arch A Path 1976 3 72 P 195-203 Glv/C 007994 Page 10 GERMANY Sheet 2 IMPERIAL CUBICAL INDUSTRIES PLC LIVER Angiosarcoma Cases - (Review Date: 1 Jan 1966) WPX/ASLJ2 - LAHGIOCASES, L 5 2 3 4 56 7 6 9 10 11 12 13 14 15 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OP BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OP DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS GERMANY OS CHIOS 11 gives as Case 06) 00,00.36 Hoechst Frankfurt 02.04.60 10.12,73 36 13 05 16.12.74 Yes (NIOSH) EC Chenle Bays "cherni a try laboratorian in the Techno logical Research Department ' (NIOSH says assistant factory chen 1st which nay be wrong translation) Confirmed Reported under non-polymer1 nation workers In HIOSH list of 31.3.77 and 1 73, I don11 think thle la a correct clasalfleet Ion by NIOSH. The nan may have been Involved In VCM polymer 1 sat Ion in pilot plant or in main plant. 06 (N[OSH gives as Case OS) 00.00.32 Lonza Ualdahut 16.12.62 00.00.75 43 13 12 09.01.75 Yea PVC - Manu facture Shift Leader 07 00.00.26 Wacker Burg- 15.04.S4 12.11.75 49 2J 21 13.11.75 Yea hausen (NIOS1I aaya 12) PVC Manu facture and all work loci autocleantng 12 yra <1954-66) Foreaan Tech Dev 8 yrs (1967-1975) 06 00.00,17 Dynanlt Troiedorf 19.07.54 06.04.75 56 20 20 25.12.75 Yea t Polyworker 7 6ENC 007995 puis* GERMANY Slieec 3 IHPKNIAL <JIIKH 1 c: Al. t HI HI fl T(t I KS P1.C LIVER Aitg loss rcoua Cases - (Review Dale; l Jan 1986) UPX/ASI._2 - LAMCIOCASES, 1 6 1 23 `} COUNTRY AND REFERENCE NO NAME OR INITIALS DATE Of BIRTH 4 COMPANY 56 7 8 9 10 12 L 3 14 FACTORY FIRST VC EXPOSURE DATE OF diagnosis ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION 15 OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS GERMANY 09 00.00.34 CWil Marl 20.02.61 16.06.76 41 15 13 24.03.78 Yea High peaks 12 yra poly- worker incl 17Z auto clave ' cleaning Control roan 1 yr 10/78 Confi need Average exposure first 9 yra 150 ppm, occ 1000 ppm. Next 3 yra av, 75 ppa. Last, yr av 35 ppa 10 (NIOSII gives as Case 11) 00.00.36 CUN Marl 01.01.61 00.01.77 40 16 10 07.03.77 Yea High peaks 10 yra poly worker Incl 1 ?Z auto clave c Leaning Ave rage exposure first 9 yra 150 ppm, occ 1000 ppm. Last yr av 75 ppa. CUIt 1etter of 21.04.78 LI (NI03H gives bh Case 10) 00.00.29 Wa clter Burg- 10.10.55 2 8,06.77 47 2) 22 28.06.77 Yea High 3 yra auto La u sen clave cleaner 19 yra filter operator 12 00.00.38 DynaaiC Trotedorf 00.00.61 00.10.77 39 16 6 07.10.77 Yes 7 PVC Manu facture Autoclave worker for 6 yrs GNC 007?? luge 12 GERMANY Sheet 4 COUNTRY AND REFERENCE NO 2 NAME OR INITIALS 3 DATE OP BIRTH 4 COMPANY U1PEKIAL CHEMICAL INDUSTRIES PLC LIVER Angloaarco<ua Cases - (Review Date; l Jan 1986) WPX/ASL 2 - LANCIOCASSS, l 7 5 FACTORY 6 FIRST VC EXPOSURE 7 DATE OP DIAGNOSIS 8 ACE AT DIAGNOSIS 9 10 YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE 11 DATE OF DEATH 12 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL 14 OCCUPATION 15 OTHER CAREER HICKLIGHTS \l OTHER COMMENTS GPRHAWY 13 H 15 (NIOSH gives thlk aa Pa BO t3) 16 00.00.14 Lonza Waldahut 00.00.60 08.04* 78 63 00.00.29 Wacker Burghauseri 19.10.53 09.10,78 49 00.00.23 Dynaa(c Trolsdorf 10.01.55 07.08.78 {Lelbach suspected ASL at Feb 1975 laparotomy) si 18 14 19.05.78 Yea Not an Angiosarcoma Id his letter of 21 12 81, Mr Frledel said chla was a Plstteneplthelfcarzlnom Per Spelaerohre (a carcinoma of the oesophagus) not attribut able to VCH & not recognised aa an Indust rial disease 25 25 23.10.78 Yea ? Autoclave cleaner end worker* Drier operator. Later alilft leader 23 20 0>.08.76 Yes nigh Autoclave ASL and worker till Hepatoce]lular 1964. Carclnoaa Leader and naater GENC 007997 F W Beat letter of 30th June 1980 enclosing data from Mr H P Frledel of BG Chemle 7 U Beat letter of 30th June 1980 enclosing data f roa K P Frledel of BG Chemle wlthdrawing this case Angiosarcoma confirmed 09/79. Sms detaj L of this 6 slso esses 9, 13, 15, 16 617 given In NRW Report for 1978 Angiosarcoma confirmed, full details of Illness since March 1973 given In NRW Med Jnsp Rep for 1978. Different details given Jn VC 1 Assoc 1 a tcd Dlaeuse by Lelbach and Msrsteller 0961 ) n?l. Page 13 jERHANY Sheet 5 IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Angloearcona Cages - (Review Date: 1 Jan 1986) WFX/ASL 2 - 1ANCI0CASES.18 i 2 3 4 56 7 8 9 10 U 12 13 14 15 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS GERMANY 17 (NIOSII gives aa Ca ee 13) 18 19 20 21 22 00.00.37 Dynamlt Trcladocf 01.11.61 14.08.38 41 00.00.13 Hoechat Cendorf 00.00.S3 25.12.79 66 16 11 26.08.78 Yea High Autoclave No Angiosarcoma worker conf 1rned. Annual report of the North Rhine Westphalla Medical Inapectorate for 1978 pagee 347-377 gives full detalla. Vinyl c lil orl d e dlaeaBe d1agnosed 02-02-33. Oeeophageal varices. Ra dlolog J c a 1 ly confirmed aero 24 21 25.12.79 Yes Autoclave oateolye 18 Wo rke r 00.00.25 Dynamic Trotadorf 1 8.10.54 00.08.79 54 25 18 22.02.80 Yea High Autoclave He tea tealng Worker ASL Dr Beechc letter of 13-04-82 to Dr W C F Adam* oo.oo.li Dyuault Troladorf 14.02.61 00.04.80 65 19 13 19.10.80 Yea High Autoclave Haenanglo Worker Endothelioma of 1 lver wj tit Me taatavee Dr Besche letter of 13-04-82 to Dr W G P Aduma oo.oo.il Dynamic Troladorf 01.01.62 00.09.79 66 16 13 19.06.80 Yea High Autoclave pronounced Haenanglo Worker and clinical Endothelioma worked In 1 Jver of liver wlth drying altup eymtoua) Hetaataaea Dr Beaclie letter of 13-04-82 to Dr W G P Adaiaa oo.oo.it DynomJt TruIsJorf 15.10.61 28.00.00 59 19 06.12.81 Yea Ketaataalng ASL High Autoclave Worker Chorgehand, subsequently Foreman Dr Bcsche letter of 13-04-82 to Or U G P Ad a ns GENC Q07998 pa8e ** GERMANY Shee c 6 IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Angiosarcoma Cases ( Rev Dace: 1 Jan 1986) WPJE/ASL_2 * LANC10CASES.19 I 23 Jk COUNTRY AND REFERENCE NO NAME OH INITIALS DATE OF BIRTH GERMANY 23 UF 00.00.27 4 COMPANY Wacker 5 FACTORY Bu rgLausen 67 FIRST VC EXPOSURE DATE OF DIAGNOSIS 1955 26,03.79 B AGE AT DIAGNOSIS 52 9 YEARS OF EXPOSURE TO DIAGNOSIS 24 10 11 YEARS OP EXPOSURE DATE OF DEATH 21 29.09.81 12 13 14 15 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS Yea High Cheats try (*300 pp) Worker - 16 OTHER COMMENTS Prof Cedlgkl states etaetaelaed. Frledel letter 19.04.85 24 IIL 00.00.23 Hacker Burg- 1969 U.10.82 54 13 12 28.05.83 Yea High Autoclave hausen (>300 ppa) Cleaner Prof Eder (Munich) letter 22.08.83. Frledel letter 19.04.85 25 E.Sch 00.00.23 Wacker Burg- 1960 2 8.09.81 58 21 13 14.01.83 Yea High Polyclave hausen Worker and Autoclave Cleaner Prof Selaalr (Munich) Frledel letter 19.04.85 26 FH 00.00.22 CWtl Karl 1953 14.06.76 54 22 22 22.11.82 Yea High Polyworker Ui mule Itepatit J s (LelbacU). Frledel letter 19.04.65 27 UK 00.00.28 DynaaJ C Troladorf 1955 J B.01,83 55 28 10 02.03, 84 Yea Nigh Autoclave Cleaner till 1972 Lelbach. Frledel letter 19.04.85 Page 15 ITALY IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Angiosarcoma Caeee - (Review Data: 1 Jan 1986) UPX/ASL_2 - LANGIOCASKS, I 2 i 4 56 7 8 9 10 It 12 13 14 15 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY ITALY 01 (On NIOSU supple mentary Hat) LG 15.06.34 PANSAC FACTORY Mira Venice FIRST VC EXPOSURE DATE OF DIAGNOSIS 00.00.65 19.04,71 ACE AT DIAGNOSIS 36 YEARS OF EXPOSURE TO DIAGNOSIS 06 YEARS OF EXPOSURE DATE OF DEATH 03 16.04.71 11 IS TO LOCI CAL CONFIRMATION 7Yes ESTIMATED EXPOSURE LEVEL OCCUPATION PVC Bag extruder OTHER CAREER IllCHLICKTS OTHER COMMENTS Primary tumour may Lave been per 1 ca rd 1 uia . Not Homo geneous with other cases. * ** 02 SK l3.11.29 Montedison Porto 00.00.57 13.12. 72 43 15 06 27. 12, 72 Yes Marghe ra Polyworker a *k 03 VC 14.03,20 Solvay Ferrara 00.01.53 10.07. 75 55 22 21 10.07. 75 Yea High Autocleaner 1972-5 did 8 yra (195361) Autoclav e operator a variety of Joba Including 12 yra (1961 * PVC packing. 72) ** 04 PB 20,07.37 ANIC Ravenna 00.04.59 00.01.8L 43 2L 21 30.03. 81 Yea 12 yra - i yc - Never cleaned Very High Mononer operator autoclaves. See paper by *4 5 yra - CHUPPING et Non-auioker. Mediua 20 yra - al Med Lavoro Coneimeu Autoclave Vol 6 (1982) little 4 yrs _ operator A pp 555-563 alcohol. No Low other dulies AOL. In suspena- i i lon polymer isation. Area Foreman In sane Dept since 1975. 05 G Danesln 19.03.37 PANSAC Mira 00.00.67 07.03.83 Venice 46 16 8 06.04. 83 Yea Medlusn-T High Bag extruder 1967-1975 Cotwaerclat Dept 19 761983 S PaglieLunga telex of 2 Aug 1983 See Hjltonl Mod di Lavoro 65 p445, 1974. Further details In letter from Dr Monteaano of IAHC on April 1st 1982 Also sec He Item I and Ronrilnella In Acta Oncologies Vol l 1980 pugca 35 - 49. GNC 008000 Page 6 japan* IMPERIAL CHEMICAL, INDUSTRIES PLC LIVER Angiosarcoma Cases - (Revleu Date; L Jan 1986) WPX/ASL_2 - LANCIOCASES,21 l 2 3 4 56 7 a 9 10 11 12 13 14 15 16 country and REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OP DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS JAPAN ** a 01 Toaojl 01.08.22 Mitsui Nagoya 00.04.53 24.10.75 S3 22 13 24.10. 75 Yea PVC Aasoc 13 yre auto Mori Toatau aays net clave (no consent "known. cleaner by Jap PVC * Japan 1964 - Aaeoc) Tine a aaelgned to Indicated different on 25.10.75 work since exposures had 111 often at health 3000 ppo up to 1974 Japan Tinea 25.10.75 6 Japanese PVC Aaaoc letter of 3l.03.7B 02 SO 0 2.0 8. 39 00.11.58 10.08. 76 37 17 13 10.06.76 Yea Not known In polyaer- 1 eat Ion work Including autoclave cleaning Japanese PVC Aaeoc tat Lon letter of 31.03.78 * In lila letter of lat April 1982, Dr Honteaena of TAftC safe Japanese Ministry of Labour give Date of diagnosis Age of dlagnoala Years of exposure 21-08-74 52 22 SENC 008001 Pane 17 NORWAY IMPERIAL CHEMICAL INDUSTRIES PLC I.IVHK Anglouureona Cjujou - (Rnvlcu Daiet I Jan I 9116) WFX/ASL_2 - LANCIOCASES*22 1 23 A COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH 4 COMPANY 5 *. 7 6 9 10 11 12 n 14 FACTORY FIRST VC EXPOSURE PATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH 11 IS TO LOG I CAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION 15 OTHER CAREER HIGHLIGHTS 16 0TI1FR COMMENTS NORWAY OL AH 23.12.IS Norsk ileroya 00.03.SO 21.12.71 56 22 21 04,01.72 Yea Itlfih Foreaen A Hydro Autoclave aupervieor Confirmed by Dr Tli 11 sEvanaen of Nil. At APHE Ktg of 9 June 1978 Mr P KanRnee stated that AN lied been a member of a Btart*-up teem. VCM & PVC wore aade In same building. The VCM was made from acetylene SfA/r oeo02 Pttg 18 SWEDEN IMPERIAL CHEMICAL INDUSTRIES PLC I.IVKK Ang I oao rcona Caueo - (Review Date: 1 Jan 1986) WPX/ASLJ - LANCI0CABa.2J 1 2 3 4 56 7 a 9 10 11 12 13 14 15 16 COUNTRY AND REFERENCE NO NAME OR INITEALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION F. ST 1 HATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS SWEDEN a 01 NU 23.06.27 Kensno rd Sundavail 14.03,51 20.10.70 43 19 10 20.10.70 Yea Polyworker * 6102 BL 27.11.U Kenanord Sundsvall 00,01.45 00.08.72 27 27 16,08.72 Yea High VCH production Hr SJoelln's letter of 28 Kerch 1978 confirms BL was a aonoaer worker who was heavlly exposed, probably even more no chan a normal reactor c 1 cane r 03 NE 10.06.10 Keaanord Sund avail 00.05.47 18.03.76 65 29 21 19.03.76 Yea High Polyworker 04 AL 16.11.14 Keaanord Sundsvall 00.00.46 12,05.77 62 31 31 12.05.77 Yea High 1946-1958 polymer isation worker (12 yrs) & 1958- 1977 foreman (19 yce) In first 12 yrs of eaployuent had been heavily exposed. In 1974, liver abnormality and necrosis diagnosed. Data confirmed in Dr D Byren letter 18.8.77 to CEFIC 05 12.03.19 Keaaiiord Sundavail 11.05.64 22.11.BO 61 16 16 22.11.80 Yea High - 1964-1970 6 Years centrifuge Low - operator 10 Years 1970-1980 drier operator Letter of 2nd Nov 1981 f rtwa Dr DsvJd Byren * In Ills letter of let April 1982, Dr Honteauno of 1AHC aaya In Sweden's National hoard of OS Health gives 20-02-70 date of ill agnosia for Cnau 01 and 13-05-72 for Csmo 02. GENC OuS003 Page 19 JK Sheet 1 IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Angloearcona Caaea - {Review Date! 1 Jan 1986) WPX/ASL_2 - LAHCIOCASES,24 l 2 3 4 56 7 8 9 10 11 12 13 14 15 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OP BIRTK COMPANY FACTORY FIRST VC EXPOSURE DATE OP DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIACNOSIS YEARS OP EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS UK 01 WJ 20,04.01 ICl Hlllhouae 04.04.44 03.12.72 (Fox 6 Collier paper aaya 23.12.72) 71 28 22 0 3.12. 72 Yea 500 ppa 1944-7 VCM (Pox 6 1947-8 Drier Collier 1948-61 paper Autoclave aaya operator 2 3.12.72) 1961-66 Drier Lee and Harry Lancet 29-06074 page a 1316-8 Dubloua 02 fabrication caae 03 &JW 02,06.37 BP Barry 00.02.66 00.12.74 37 09 3.5 24.12.74 Yea High Autoclave cleaner Exposure Halted to 2.66 - 9.69 04 JS8 23.06.20 ICI Hlllhouae 2 6.04.54 00.06.79 59 25 16 12.10.79 Yea Med lufli- 54-5 Pre-war fish hlgh Begging Plant packer 1439-15 irt) 55-6 vehicle Drier Plant aa J ntenance 56-58 1945-54 Autoclave f 1 sli packer wo rice r 5 8-61 Cha rgehand Drier Plant 61-72 Forenan C 2/3 Plant 6NC OOo'Or/ij Page 20 UK Sheet 2 1 234 COUNTRY AND REFERENCE NO OK OS NAME OR INITIALS JK DATE OP BIRTH 30.03.14 COMPANY BP 06 CEP ] 931 BP 07 RGB 26.04.20 BP 5 FACTORY Barry Barry Barry IMPERIAL CHEHICAL INDUSTRIES PLC LIVER Anglo&arcoaa Cases - (Review Date: 1 Jan 1986) 67 e 9 10 11 FIRST VC EXPOSURE DATE OF OIACNGSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OP DEATH OB.01.51 00.10.79 65 28 21 19.11.79 1962 09.01.60 Tb79 IB 1963 "oOOo io ij 12 09.6l.BO 8.2 ll.04.BO WPX/ASL_2 - LANCIOCASES.25 12 --n----------- 14 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION 1951-52 Polycleaner 1952-55 Latex 1955-60 Polyfloor 1960-64 Poly Chargehand J964-70 Charging operator 1970-72 Drier operator 7 yra Poly Floor Operator 5 yra Creaaer on Poly Floor Polycleaner 1963-5 Recovery 1965-1971 15 OTHER CAREER IIIC1II.IGHTS 16 OTHER COMMENTS 08 UTM OB.OS.24 BP Barry 19.09.50 27.11.81 sJ *4 25.12.61 1950-1958 500 ppa 1968-1974 2 00 ppa 1950-51 1938-1948 Autoclave Kotor Mechanic operator 1948-1950 1951-1957 Operator on Chargeaan Acetylene autoclave Production building 1957-1974 Plant Shift supervisor autoclave building - Never clea tied autoclaves but supervisor4 a Job entailed entering autoclaves to Inspect theta GENC 00so05 Page n UK Sheet 3 1 23 COUNTRY AND REFERENCE "NO UK 09 KANE OR INITIALS ercu DATE OP BIRTH 07.05.25 4 COMPANY BP 5 FACTORY Barry 6 FIRST VC EXPOSURE 15,02.50 IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Angiosarcoma Caaea - (Review Daces l Jan 1986) 78 9 10 U DATE OF ACE AT DIAGNOSIS DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OF DEATH 02.03.83 58 33 29 24.02.83 12 HISTOLOGICAL CONFIRMATION Yea WPX/ASL_2 - LAMCIOCASES,26 13 it ------------- B------------- ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS Hedlm Polyworker 2 year# on AcrylonltrJle Kealn Plant. Also prior to 1950. 4 yeare RAF maintenance. 3 yeara motor car palntahop. 2 yeara in Graving Dock, Ifi OTHER COMMENTS 10 CJT 04.04.47 BP Barry 27.04.66 01 05 84 37 18 4.2 L 6.05,54 Yea High - 11 Polycleaner Heavy gooda Information months (500 1966-67. vehicle driver given In ppo). Low- Sprayerdrler until final letter 18 moiitha bagger l967- lllnea. l 8.06.54 f roo (50 ppm). 68. Blow Dr D H J Mediui - down Willlama 21 months Biripper (200 ppm) operator 1966-70. tl CLP 08.05.28 &P fia rry 19.12.65 02.06.85 57 19 16 02.06.05 Yea High Polycleaner 1965 -69 1965-68. Hed 69-79 Low 79-82 Service operator 68-69. Poly Operator 69-79. Leading Hand 79-82. 12 JT 24.01.37 ICI 11 111 house 16.09.57 03.06,85 40 28 28 06.12.85 Yea Low 1957-59 Spare nan, High 59-74 bagging Low 74-85 floor 1957-59. Autoclave Operator 1959-85 Letter of 04.06.85 Dr Paul Smith and letter of 04.06.85 Dr D H D Evans Oeeopbageal haemorrhage due to oeaopliagea 1 varices due to Angioaa rcome of liver Letter 2 6.06.85 Dr F I l.ee GENC 00S006 Page 22 USA Sheet 1 IMPERIAL CHEMICAL INDUSTRIES PLC l.IVEA Angtosarcoaa Cases - (Review Date: 1 Jen 1906) UR syatee of dates DAY - MONTH - YEAH WPX/ASL_2 - LANCIOCASES,2 7 1 2 3 4 56 7 8 9 10 11 12 13 14 15 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER RICHLICUTS OTHER COMMENTS USA Ol Earl 17.10.23 BFC Louis 09.12.48 03.03.73 49 24 21 03.03. 73 Yea Pa rks ville Pot Cleaner (Block Jau 1974) p 53 History given Rolling Stone In Anual a HY Art ACAD SCIENCES Ref 1 NY Acad Vol 329 (1979) of Sc Syap page 190 In 1974 Paper by Also Block B R Cot tine of J aaa 1.7.74 OSUA P 53 02 19.08.33 BFC Louis 15.1L.55 00.05.70 37 14 13 27.09.71 Yea ville (NIOSH says 2 8.09.71) Pot Cleaner (Cf Block) Ref l Alao Block JAMA 1.7.74 P 53 03 Edward 25.05.L5 BFG Louis 2B.ll.45 19.12.73 58 28 28 19,12. 73 Yea Dinuldd(a ville 04 15.01.24 BFG Louis 06,07.52 19.08.67 43 15 15 07.01.68 Yea ville Pot Cleaner (Cf Block) Louisville Courier Journal 02-09-80 Pot Cleaner (Cf Block) Re f l Also Block Ref l Also Block 05 25.Ol.J2 BFG Louis 19.06,44 09.04.64 52 20 20 09.04.64 Yea ville Pot Cleaner (Cf Block) Kef l Also Block 06 Ray 23.11.28 BPC Loula- 17.01.62 00.02.74 45 12 12 24.07.75 Yea Austin ville Jernes? US Air Force Pot Cleaner (Cf Block) Ref 1 + Louisville Tines 23. 7. 75 Retired April 1974 Also Block 07 Charles 03.05.22 UCC S Charle 27.08.44 00.00.63 45 24 17 23.03.68 Yea T Suart ston Ref l oa 06.05.20 Goodyear Niagara 07.10.46 00.08.61 41 15 15 29.08.61 Yes Ref l SENC 008007 Page 23 USA Bliect 2 IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Angiosarcoma Cases - (Review Date: 1 Jan 1986) UK system of dates DAY - MONTH - YEAR WPX/ASL_2 - LANCIOCASES.2 0 1 2 3 A 56 7 8 9 10 11 12 13 14 15 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BlHTIt COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH II1STOLOCI CAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER UICkILICHTS OTHER COMHENTS USA 09 Raymond SettleFinger? too BFC Louis- 28.05.45 01.03, 74 43 29 24 11.03.75 Yea 2000 pps vllle Ref 1 has wrong figures re flret exposure. Loutsv ille Tinea 29.10.74, 12.3.75, 10.3.76 ID 16.08.13 Coodyesr Niagara 12.06.51 00.05.6B 55 17 17 10.05.68 Yea Ref 1 11 27.OS.09 Goodyear Niagara 14.10.46 00.03,70 61 23 23 16.03. 70 Yea Ref 1 12 Francis A 17.11.18 FIrestone Potts town 13.07,49 02.05.69 50 20 19 02.05.69 Yes Nigh 10 yra 10 yre as Utility 6 Ref 1 + letter Saeima a Pa reactor op. Service op. of 26 April (not cleaner Bagger 1978 from - separate Dryer op. Russell A Park crew cleaned Stripping op. to J T Seawall autoclaves) 3 yra prior of MCA service in tyre plant 13 Richard 01.12.21 UCC S Charle U.12.42 00.05.74 52 32 26 07.04.74 Yea 2000 ppm Edwa rd ston Clendenln Charleston Dally Mall 21.7.75 14 Never diag nosed as ang iosarcoma of liver. Inform al Ion given In letter 22 Hey 1984 from J A Salg. 1 5 Accountant; gen ~ GO800 3 ASL - No evi dence of VCM exposure. Page 24 USA Sheet 3 IMPERIAL CHEMICAL INUUHTK1Kfl I'l.C LEVER Angiosarcoma Cases - {Review Datet 1 Jan 1986) 1, 2 1 4 56 7 8 9 10 11 UK System of daces DAY - MONTH - YEAR UFX/ASL 2 l.ANC10CASES,29 12 11 14 15 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF OtACNOS IS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH UISTOLOCICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS USA 16 Janes Howard 04.11.27 BEG l.oule* vllle 08.05.50 00.00.69 41 19 04 27.03.69 Yes 1951-4 VCM polymer isation From 1 9 54 Table 4 In onwards In Uagoner Army and other Teatimony to service. US Senate 46-50 Army Confirmed In M N Johnson ltr 07.08.78 l.otila- Yea 17 Pee renboon 06.05.1V BFC vllle 23.06.55 11.10,74 41 19 19 16.10.80 on 11.10.74 but no poac-mortem 16.10.80 Dr M N Johnson letter of 24.2.61 con firmed death 6 years after d1aenosle IS Charlie 22.04.28 BFG Avon Lake 15.09. 54 00,00.75 46 21 11 02,11.75 Yea 11 yra Navy Arthur autocleaner 8 yra on Estol Tyre Store plaatlclser A Carboaet opera t Ion Confirmed In H N Johnson ltr 07.08.78 Alao Rolling Stone mag. L5.0l.76 19 Virgil 00*00.15 UCC S Charle OC.00.43 19,06.75 60 32 32 06.04.76 Yea 2000 ppm Christian ston Ullllaosport Sun Cazette 21 June 1975 Charieston Dally Hail 21. 7.75 20 31.08.17 Goodyear Niagara 00.00,55 30.01.7b 58 21 18 10.01.76 Yea KIDSH letter of 25.10,79 21 Cheater 02.09.09 UCC S Charle 00.12.46 Early 77 67 30 22 02.01.77 Yee Hinkle ston 28 yra with UCC at SC Retired News release 23.2.77 SENC 008009 % I. Page 25 USA Sheet 4 imperial chemical industries plc LIVER Angiosarcoma Cases - (Review Date; 1 Jan 1986) UK system of dates CAY - MONTH - YEAR WPX/ASL_2 - LANGI0CASES,30 2 3 4 56 7 8 9 10 11 12 13 14 15 COUNTRY AND REFERENCE NO HAKE OS INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OK DIAGNOSIS AGE AT DIAGNOSIS years OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION F. ST I HATED EXPOSURE LEVEL OCCUPATION OTHER CAREER illGNLICIITS OTHER COMMENTS jUSA 22 02.10.21 BFC Louis- 11.07.47 00.01.76 52 29 vl lie 21 00.00.23 Great FI tcliburg OS.09.58 06.04,73 American Mass. Chealcal Company 24 Charles 17,05.17 UCC S Charle 1939 37.05.77 Edward ston Hoore 50 60 15 38 {25) % Remov al froa regl ater confl raed In R \ anlnskl Jett er of 5 Nave uber 1980 I 28 04.12.76 Yes - 14 06.04.73 Yea LoulavllJe Tinea 26.1.76 said he was rite 10th AS vlctIn at Bella Lane of whom S had died by 26.1.76 In hla letter of 16.09.81 Dr H N Johnson confirms this J a the case described by Dannaher Taaburro 6 Yam In Feb 1980 Ab J fled lei ne Vol 70 p2B0 24T (NIOSI1 says 26) 27.05.77 Cholanglosarcoaa (Jt Kaminski 26/2/79) HedliM to high for 24 yra 1941-65 non- 193>-39 was N M Uheeler solvent off and on letter of vinyl resin labourer unit and 1919-4 I nay 18.8.77 to J Stafford dispersion have been vinyl resins exposed aa unit first rear tor gives details Rose Kaminski letter of aa fitter c1eane r 26/2/79 helper, then 1943 became B Kaminski ahlf t shift fitter utility Ben 1946 became (5 Nov 1980) suggests that shift utility NlftStl -111 man r.tain on 26.04.65 register since employment wee thi a neoplasm terminated may he uusocl- ated wlth ASL. R N Uheeler letter of 20/2/79 and Roue Kaminskl letters of 26/2/79 and 5/11/80 GENC 003010 Page 26 USA Sheet 5 IMPERIAL CHEMICAL INl>USTB IRS PLC LIVER Angtosarcoaa Cases - (Review Date: 1 Jan 1966) CJK aystea of dates DAY - MONTH - YEAR WPX/ASW - LANGiOCASKS,3l l 23 COUNTRY AMD REFERENCE NO USA NAME OR INITIALS DATE OF BIRTH 26 John Berry 07,07.23 4 COMPANY BFC 5 FACTORY Louls^ vl lie 6 FIRST VC EXPOSURE 03.10.47 27 J L 11.05.16 UCC Forrest S Charie st Oi 01.07.41 28 29 JO WVN 11*04,17 UCC 12,10.07 UCC S Charle oo.ga.44 ston S Charle 00.05.42 ston 22.07.22 Tenneco Fleming to i U.06.64 Chemicals 31 08.11.23 UCC S Charle 12.05.46 ston 7 DATE OF DIAGNOSIS 00.00.77 (up to 1 years after death) 30.11.78 03,11.78 00.03.80 30.12.ao 01.08.81 8 ACE AT DIAGNOSIS 52 (death) 62 61 72 56 57 9 10 11 YEARS OF EXPOSURE TO DtACNOSTS YEARS OF EXPOSURE DATE OF DEATH 29 (death) 18 11,02.75 37 20 25.11.78 (NIOSkI says 27 and C Dally Hail 25) H 13 Oi.U.78 38 16 01.03.60 17 30.12.80 35 U 02,04,82 12 bistolocica! CONFIRMATION 13 ESTIMATED EXPOSURE LEVEL 14 OCCUPATION 15 OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS Yea Yes Yes Yes Yea Yea Exposed In Various Jobs R Kaalnekl sons degree in PVC letter of LO 22 plants from 26/2/7 9 and chemicals cold room to Prof. Taeburro but main paste letter of exposure recovery to was to VCH, PVC charging 9/1/79 probably operator to high paste charging. Ill August 1965. Terninated employment Jnn 1966 high Operator to Exposure In R K Wheeler 10.10.76 bulk and Itr of 4 Jan dispersion PVC 1979 and manufacture Charleston Dally Hall 30.11.78 and R Xaalnskl 26/2/79 R Kaminski letter of 6/4/79 R Kaminski Letters of 19th June I960 6 5th Nov 1980 6 - Unknown Maintenance 9 - Minimal Mechanic 6 yrs Elsewhere l\ yrs Boiler house Operator 9 yrs High (But Chenleal From 1959 to Dr Dacey not as high Operator In 1976 Aliphatic letter as reactor charge CheaLcala 16.10.81 and cleaner reactor operator and R N Ukieuler would experience) frost July 1976 letter of to date 9,11.81. Worked as Foreman Alan Dr Dacey labourer A)iphatlc letter of from Chemical 07.03.83 re June L941 Ope ration date of death. to May 1946 and uuy huva cleaned reactors In GENC UOS 011 that t Lee Page 27 USA Sheet 6 IMPERIAL CHEMICAL INJiUSfKfES LIMITED LIVER Angl-onarcoma Caana - (Review Oatet l Jan 1986) UK syatea of dates DAY " MONTH - YEAR VJPX/ASL__2 - I.AIIC(OCAES,32 L 2 3 4 56 7 8 9 10 11 12 13 14 15 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OP emu COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIACNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIACNOSIS YEARS OP EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER highlights OTHER COMMENTS US 31 C U Clroux 22-02-08 Monsanto ! prihgf lel< 15-10-51 Hess 00-07-79 71 US 33 S Ferguson 0 8-10-2 7 Jnr BFC Loulsvlll : 09-09-54 11-05-81 54 US 34 He Bytuo. 29-01-34 BFG Loulsvlll t 1955 03-11-82 46 US 35 US 36 09-03-12 UCC S Charle 23-07-44 ston lfl-07-83 71 27-08-32 The General Aahtab T1 re end Ula Rubber Co li-06-56 21-0 8-83 50 28 14 17-05-80 An autopsy The death 1940-1951 {In PVC usa done and certificate Varloua Jobs autoclave area) Lued late cauae of death given gave Mr Giroux' usual In polyaer aanufacture BUTVAR as occupation LUSTSEX 'Anglosarcoaa aa kettle 1951-1964 operator Varloua jobs in In and 'chealcele around PVC Indue try . autoclavee 1964-1973 Various clerical jobs In PVC polyaeriaati in facility/ Retired 01-03-73. Inforoatlon given In letter of 24 February 1982 froa Dr Halter C Barnea of Monaunto Springfield to Dr A Munn of Monsanto Eu rope. IS 28 Alive Yes Multiple Jobs inc lading Poly Operator + Polvcleaner. Prof Tfluburro letter of 12 Aug 1982 + Dr H N Johnson letter of 28 Feb 1 983. 27 10 04,08,83 Yes Poly Operator + Autoclave Cleaner 1955-65. 1965 left BFG to becoae s Clergyman. Dr M N Johnson letter of 3 Nov 1982, 28 Feb 1983 and 9 Aug 1984. 39 14 18-07-83 Yes High fro* 1944 to 1955. Hedlu* fro* 1955-1958 Dr Dacey letter of 5 Sept 1983. 27 27 Alive Yea Moderate 1956-56 labourer 1956-57 prod helper 1957-70 operator 1970-75 electrician 1975-preaent. operator 6ENC 003012 R U Laundrle letter of 12 Sept 1983: spotted at aeJlcal May 1983. Test Ing coieuaonced May 1983 Page 28 USA Sheet 7 IMPERIAL CHEMICAL INDUSTRIES LIMITED LIVER Angiosarcoma Cases - ( Review Date: 1 Jan 1986) UK system of dace DAY - MONTH - YEAR WPX/ASL_2 - LANGIOCASES,33 L 2 3 4 56 7 8 9 10 U 12 13 14 15 16 COUNTRY AND REFERENCE NO NAME OH INITIALS DATE Or BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE QT DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL 0CCUPAT10M OTHER CAREER HIGHLIGHTS OTHER COMMENTS US 37 Hr J 29 08 29 arc Louis 1953 06 08 84 54 31 22 06.08.84 Yes High Uorked Payton ville regularly la PVC area. In the early deya was a reactor cleaner 1953-75. Information given in letter 09.08.64 from Dr H N Johnson US 38 JUB 28 08 22 Air Calvert 00*02.63 19.01.84 61 20 20 28.10.83 Yea High Normal pro Products City 1963-1982 gression from helper to senior operator, cleaned reactors, stripping and recovery areas as well aa charging operator. Thrombo cytopenla ami ] euko pen 1 a since 1978. Cold treatment lor arthritis 1976. Under Dr1s care about 6 months before death, had passed standard physical exam ination 3 months earlier. J Ba'-r letters of 22.10 . 84 23/01/85. GENC 008013 Page 29 YUGOSLAVIA IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Angloaarcona Cases - (Review Date; l Jan 1986) UPX/ASL_2 - LANCIOCASE S,34 2 3 4 56 7 6 n9 10 12 13 14 15 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OP BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HICHLICHTS OTHER COMMENTS YUGOSLAVIA 01 05.04.14 Jugo Spile 00.00.53 06.04.73 59 20 20 08.04.73 Yea Vinli SARIC et al paper Env Heal tit Perepect tve Vol I 7, pp 189-192 1976 02 15.M.31 Jugo Split 00.00.50 12,07.73 42 23 16 12.07.73 Ye** Vlnll 03 21.12.31 Jugo Split 04.06.54 11,01,76 45 22 22 Ll.0l.76 Yea* Vlnll VCH Production VCM Production *ln hla letter of 3 Oct 1978, Dr Spirtaa of NIOSH changed the itatus of Case 02 to VCH product Ion eaployec. Dr Spirtaa alao notified a new Case 0 3 also* VCM prodoctlon worker 04 11.06.30 Jugo Split 15.12.56 03,09.78 48 20 16 03.09.76 Yea Vlnll Rose Kanlnskl Letter of 19th June 1960 and IARC letter of 1 April 1982 GENc 80 M Page 30 TABLE 1 (Review Date - 1 Jan 1986) Incidence of ASL Cases Per Annum By date of dea^h 1955 .............. 1 60 7 .......................................................................................... 1 8 .......................................................................................... 0 90 1960 .......................................................................................... 0 1 .......................................................................................... 1 21 3 .......................................................................................... 0 4 ................................................................................................................................................... 2 5 .............................................................................................0 6 .............................................................................................0 7 .......................................................................................... 1 8 .......................................................................................... 5 9 .......................................................................................... 3 1970 .......................................................................................... 2 1 .......................................................................................... 3 2 .......................................................................................... 5 3 .............................................................................................8 4 ................................................................... 5 5 ........................................................................................... 11 6 ..................................................................................... 11 7 ................................................................. 9 8 ..................................................................................... 10 95 1980 ............................................................................................. 0 1 .......................................................................................... 5 2 .......................................................................................... 2 3 .......................................................................................... 9 4 .......................................................................................... 5 5 ........................................................................................_;_2 Total 117 N.B. 1 Does not include Italian 01 but does include German 03. 2 The 1977 total includes US case 24 which is a Cholangiosarcoma. 3 The 1982 total does not include US 33 and F 15 who are alive. 4 The 1983 total does not include US 36 who is alive. WPX/AST, 2 - LANGTOCASES . 35 Page 31 Distribution of ASL Cases by Country TABLE USA W Germany France UK Canada Sweden Yugoslavia Italy Czechoslovakia Japan Belgium Norway 35 AAA 26 AA 18 AAA 11 10 5 A AAA 4 AA A AA 4A 2 2 2 '1 (Review Date - 1 Jan 1986) 2 Total 120 * Omit ItOl - atypical case of PVC bag extruder. ** Includes GE03 aerosol can filler. *** Includes case US 24 which was diagnosed as Cholangiosarcoma & US 33, and 36; and F 15 who are alive. **** Includes one monomer worker. ***** Includes two monomer workers. l.e Western Europe North America Rest of World 67 45 8 WPX/ASL_2 - LANGIOCASES,36 Total 120 6NC 0080U & 'Xf. Page 32 Pattern of ASL Cases by Factory TABLE 3 (Review Date - 1 Jan 1986) (a) W Europe Of the 67 cases in W Europe, 57 have occurred in clusters at 11 factories. Of the 26 German cases, 23 have occurred in clusters at 4 factories. ASL Cases Dynamit, Troisdorf, Germany Chloe Chimie (Formerly RP), St Fons, France BP, Barry, UK Wacker, Burghausen, Germany Kemanord, Sundsvall, Sweden PCUK, Brignoud, France CWH, Marl, Germany ICI, Hillhouse, UK Solvay, Tavaux, France Lonza, Waldshut, Germany Solvay, Jemeppe, Belgium 11 8 8 7 5 5 3 3 3 2 2 57 NB: There are 32 pre 1962 PVC plants in W Europe; 18 of these have had ASL cases (Ref Table 8) (b) N America Of the 45 cases in N America, 38 have occurred at four factories out of a total of 54 factories:- In N America 43 plants have not had ASL cases. BFG, Louisville, US BFG, Shawinigan, Canada UCC, S Charleston Goodyear, Niagara ASL Cases 14 10 10 4 38 NB: There are 28 pre 1962 PVC plants in N America; 11 of these have had ASL cases (Ref Tables 9 & 10) (c) Rest of World The 8 ASL cases are believed to be in 1 cluster of 4 and 2 clusters of 2 cases. WPX/ASL_2 - LANGIOCASES,37 008017 Page 33 TABLE 4A Latency Periods (Years from first Exposure to Diagnosis) (Review Date - 1 Jan 1986) W Europe Country Belgium France Germany Italy Norway No of Cases 2 18 26 4 1 Total Years 35 459 495 74 22 Average 17.5 25.5 * 19.04 * 18.5 22 N America Sweden UK 5 122 24.5 11 254 23.09 * 67 1461 21.80 Rest of World US Canada 35 886 25.31 * 10 204 20.4 * 45 1090 24.22 Summary Czechoslovakia Japan Yugoslavia 2 2 4 8 30 15.0 39 19.5 85 21.2 154 19.2 W Europe N America Rest of World 67 45 8 120 1461 1090 154 2705 21.80 24.22 19.2 22.54 GENC 008018 Of the countries with ? 1Q case3( France, UK and USA have an average latency period above world average, Germany and Canada below world average. DISTRIBUTION OF LATENCY PERIODS TABLE 4B (Review Date - 1 Jan 1986) 0-9 yrs 10-14 yrs 15-19 yrs 20-24 yrs 25-29 yrs 30-34 yrs 35+ yrs Total Average Latency Period Belgium 2 2 17.5 Canada 3 52 10 20.4 Czechoslovakia 11 2 15.0 France 1 4 3 5 2 3 18 25.5 Germany 5 9 9* 3 26 19.04 Italy 22 4 18 .5 Japan 11 2 19.5 Norway 1 1 22 Sweden 2 21 5 24.5 UK 1 4 42 11 23.09 USA 2 7 8 8 5 5 35 25.31 Yugoslavia 4 4 21.2 TOTAL 1 12 32 33 24 10 8 120 22.54 * Includes C 03 aerosol can filler WPX/ASL_2 - LANGIOCASES,39 GENC 008019 Page 35 (Review date 1 January 1986) TABLE 4C LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE MAX POSSIBLE LATENCY PERIOD 47 46 45 44 43 39 38 34 33 29 28 24 23 19 18 14 13 YEAR OF FIRST EXPOSURE 1939 1940 1 2 8 9 1950 1 2 8 9 1960 1 2 8 9 1970 1 2 LATENCY PERIOD (NO OF YEARS) ARITHMETIC MEAN OF LATENCY PERIODS 38* 37,21,37,41 32,38_________ 38,14 ,32 28,11 ,24,20,24,34,39 27,22 ,28,29 21,29 ,31,26,28,15,23, 30,35 29,24,29,28 28,24,34 30,26,20 26,22,31,19,23,14,33 19,28,17,28 21**,15 25.22 ,23,22,20,31,22 21,21 ,25,25,21,28***, 22 22.23 ,24,14,19,21,27 27*** 24.28 21,12 27*** 19,17 15.13.16.28 18,18,15,17,20 16,21 13,18 ,21 15,16 ,16,16,19,19,12 13,18 ,17,12,18_________ 16,17,20,21 16,17 11,19 9,18 16 244 34.86 7 718 - 26.59 27 458 =* 24.11 19 725 = 21.97 33 368 = 16.73 22 180 = 16.36 11 13 13 TOTAL 120 CASES 2706 = 22.55 120 * Cholangiosarcoma ** Aerosol can filler *** US33 and 36; and F15 still alive. VIOLA MALTONI GOODRICH WPX/ASL_2 - LANGIOCASES,40 GENC 008020 Page 36 (Review date 1 January 1986) TABLE 4D LATENCY PERIODS OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION "' * Cholangiosarcoma ** Aerosol can filler *** US33 and 36; and F15 still alive WPX/ASL_2 - LANGIOCASES,41 GEHC 008021 TABLE 4E Page 37 (Review date 1 January 1986) PLANT START UP DATE LATENCY PERIODS OF ASL CASES IN SPECIFIC PLANTS (10 OR MORE CASES) NO OF CASES AVERAGE LATENCY PERIOD LOUISVILLE USA SHAWINIGAN CANADA S CHARLESTON USA TROISDORF W GERMANY 1940? 1941? 1939? 1954 12,14,15,19,19,20,24,27,28,28,28,29,29 31 11,12,14,21,22,23,24,24,26,28 24,30,32,32,34,35,37,38,38,39 12,13,16,16,18,19,19,21,23,25,28 14 10 10 11 23.07 20.5 33.9 19 .09 WPX/ASL_2 - LANGIOCASES,42 SENC 008022 Page 38 (Review date 1 January 1986) TABLE 4F LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (10 OR MORE CASES) YEAR OF FIRST EXPOSURE 1939 1940 1 2 3 4 5 6 7 8 9 1950 1 2 3 4 5 6 7 8 9 1960 1 2 S CHARLESTON USA 38 37 32,38 32 24,34,39 30,35 LOUISVILLE USA 20 28,29,27 29,28 24 19 15 31 28 14,19 12 SHAWINIGAN CANADA 21 14 11,24 22 26,28 24 23 12 TROISDORF W GERMANY 21,25 23,28 12 13 16,16,19,19, 18 WPX/ASL 2 - LANGIOCASES,43 G'ENC 00802 Page 39 (Review date 1 January 1986) PLANT SUNDSVALL SWEDEN BRIGNOUD FRANCE ST FONS FRANCE TABLE 4G START-UP DATE LATENCY PERIOD OF ASL CASES NO OF IN SPECIFIC PLANTS(4-9 CASES) CASES AVERAGE PERIOD 1945 16,19,27,29,31 5 24.4 years 1950 11,16,18,26,30 5 20.2 1939 21,28,29,37,38,27,41,35 8 31.88 BARRY UK BURGHAUSEN W GERMANY 1948 1933 9,17,18,28,31,33,18,19 17,21,22,25,24,13,21 8 21.62 7 20.43 NIAGARA USA 1947 15,17 ,21,23 4 19 SPLIT YUGOSLAVIA 1941 20,20,22,23 4 21.25 WPX/ASL_2 - LANGIOCASES,44 3ENC 008024 Page 40 (Review date 1 January 1986) TABLE 4R LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (4-9 CASES) WPX/ASL_2 - LANGIOCASES,45 GENC 003025 Page 41 TABLE 5 (Review Date - 1 Jan 1986) Annual Incidence of ASL Cases (Date of Death) by Geographical Area 1955 7 1961 2 4 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980 1 2 1983 1984 1985 TOTAL Western Europe 1 1 1 1 4 1 3 6 6 6 7 5 6 5 1 6 4 2 66* ** North America 1 1 1 1 1 5 2 1 2 1 4 2 4 3 '3 2 4 0 1 3 1 43** Rest of World 1 3 1 2 1 - 8 Annual Total 1 1 1 1 2 1 5 3 2 3 5 8 5 11 11 9 10 5 10 5 2 9 5 2 117 Cumulative Total 1 2 3 4 6 7 12 15 17 20 25 33 38 49 60 69 79 84 94 99 101 110 115 117 Key Events Viola Maltoni Goodrich * Includes G03 aerosol can filler but omits It 01 bag extruder ** Does not include US33, and 36; and F 15. All still alive. GNC fine,,. WPX/ASL 2 - LANGIOCASES,46 Page 42 (Review date 1 January 1986) TABLE 6 ASL CASE NUMBERS BY YEAR OF DEATH AMO GEOGRAPHICAL LOCATIONS (EXCLUDING ITOl') KEY EVENTS WESTERN EUROPE NORTH AMERICA REST OF WORLD Viola Maltoni Goodrich 1955 6 7 8 9 1960 1 2 3 4 5 6 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980 1 2 3 4 5 Total FI G1 Swl G2 Nl,Sw2,UKl,It2 G3*** G4.G5.UK3 F2,F3,G6,G7,G8,It3 B1,F4,F5,F6,F7 ,Sw3 F8,F9,G10,G11,G12,Sw4 F10,F11,G9,G13,G15 G16.G17 F12,F13,UK4,UK5,G18' UK6, UK7.G19,Sw5,G20,G21 It4,F14,UK8,G22,G23 G26 UK09,It5,F17,B2,G24,G25 UK10, F16, F18, G27 UK11, UK12 66 Cl C2 US8 C3 US5 Cz2 C4,C5,US4,US7,US10 US12.US16 US 11 C6.US2 C7 C8.US1.US3.US23 C9,US13 US6.US9.US18.US26 US19.US20.US22, C10.US21.US24* US27,US28 Y1 ,Y2,Czl Japl Jap2,Y3 Y4 US17, US29 , US30, US32 US31 US35. US34, US38 US37 43*** 8 1 * Cholangiosarcoma ** Aerosol can filler *** Does not include US33, and 36; and F15. All still alive. WPX/ASL_2 - LANGIOCASES,47 GENC 0080 2? Page 43 (Review date 1 January 1986) TABLE 7 ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION (EXCLUDING ITOi) '-- KEY EVENTS WESTERN EUROPE NORTH AMERICA REST OF WORLD Viola Maltoni 1939 40 1 2 3 4 5 6 7 8 9 50 1 2 3 4 5 6 7 8 9 60 1 2 3 4 5 6 7 8 9 70 1 2 3 Frll,Frl6 Frl4 UK1 Sw2 Frl,Fr3,Sw4 Sw3 Fr9, Frl7 Frl2,Fr4 Fr7,Nl,UK8,UK9 Swl ,UK5 G3** G15,It3,G26 G7,G8,UK4,G19 G11,G16,G18, Frl5*** G23 ,G28 FR10.G1 Fr8,G4,It2,G2,UK12 Fr6,B1 Fr2,It4 G5,G13 ,G25 G9.G10.G12.G17 ,G20 ,G22 G6.UK6.G21.B2 Frl3, UK7,Frl8 Sw5 Fr5,UK11 UK3, UK10 It5 G24 US24* C3.US27 US13, US29 C2.US19 Cl ,C5 ,US5`,US7 ,US28 ,US35 C4,US3,US9 C7 ,C9,US8,US11,US21 ,US31 C6.US22.US26 US1 US12 US16 Y2, Cz2 US10, US32 US4 CIO, US37 US18,US33*** Japl.Yl Y3 US2.US17.US20.US34 US36*** US23 Czl Jap2,Y4 C8 US6 US38 US30 Total 67 45 8 * Cholangiosarcoma (US24) ** Aerosol can filler (G3) *** US33 and 36; and Ft 15 are still alive. WPX/ASL_2 - LANGIOCASES,48 GENC 008028 Page 44 WPX/ASL_2 - LANGIOCASES,49 (Review date 9 January 1986) TABLE 8 WESTERN EUROPE PVC PRODUCERS - START-UP DATES vs ASL CASES (OMITTING GQ3 & It .01) START-OP (DUNTRY NAME COMPANY NAME IDCATION ASL CASE NUMBER YEAR OF YEAR 1931 West Germany BASF Ludwigshafen 1st Exposure 1933 West Germany Wacker Burghausen 04,07.11.15,23,24 25157,54,55.53.55.69.60 1938 Italy Montecatini Acna 1939 France Rhone Poulenc St Fons 03,09,10,11,14, 46,48,56,41,43, 15,16,17 55,41,48 1940 United Kingdom ICI Runcorn 1940 United Kingdom ICI HillhovEe 01,04,12 44,54,57 1945 Sweden Kemanord Sundsvall( Stockvik) 01,02,03,04,05 51,45,47,46,64 Switzerland Lonza Sins 1946 France Rhone-Poulenc Rousillon 01 46 1947 Italy Montedison Porto Marghera 02 57 1948 United Kingdan BP Chem Barry 03,05,06,07,08,09 66,51,62,63,50,50 10,11 66,65 West Germany Huls Marl 09,10,26 61,61,53 1949 Belgium Solvay Jemeppe 01,02 58,62 1950 France Puk Brignood 02,04,05,06,12 59,49,65,58,49 France Rhone-Poulenc St Auban 07 50 Holland Shell Pernis Norway Norsk Heroya 01 50 1951 Italy Montedison Brindisi 1952 Italy Montedison Temi 1953 Austria Halvic Hallein France Solvay Tavaux 08,13,18 57,63,63 Italy Solvay Ferrara 03 53 Spain Rio Rodano Hemani United Kingdom BIP Aycliffe West Germany Hoechst Gendorf 18 55 1954 West Germany Dynamic Troisdorf 01,02,08,12,16, 56,57,54,61,55,61, 17,19,20,21,22,27 54,61,62,61,55 1955 Spain Monsanto Iberia Monzon 1956 Spain Caiqsa Sabinanigo Hispavic Torrelavega 1958 West Germany Solvay Rheinberg 1960 Italy S C Ravenna Ravenna 04 59 1960 West Germany Lonza Waldshit v 06,13 62,60 1962 Portugal Cires Oporto 1965 France Rhone-Poulenc Montlucon Italy Pozzi Ferrandina West Germany Wacker Cologne 1966 West Germany Hoechst Knapsack(Frarikfurt) 05* 60 1967 France AT0 Chimie Balan Spain Rio Rodano Miranda de Ebro Greece Esso Pappas Diavata Salonika 1968 Belgiun Badiphil Antwerp 1969 United Kingdom Vinatex Staveley Italy Runlanca Cagliari Sardina 1970 Italy SIR Porto Torres Sar United Kingdom ICI Runcorn 1971 Italy S C Ravenna Ravenna Spain Hispavic Martorell Sweden Kemanord Stenungsund United Kingdom BP Chem Baglan Bay 1972 Finland Fekema Svartback Holland DSM Beek Limburg 1976 France Soc Art D'vinyl Mazingarbe 1977 Spain Monsanto Iberia Tarragona * Laboratory worker in Research Department PANSAC, Mira Venice, case not included (It 05), due not knowing start up date of the Plant. 5ENC 00802? Page 45 (Review date 1 January 1986) TABIE 9 USA IVC PRODUCERS - START-UP DATES vs ASL CASES START-UP (XMPANY NAME LOCATION ASL CASE YEAR OF YEAR NUMBER 1st EXPOSURE 1939? *UCC S Charleston 07,13,19,21,24, 44,42,43,46,39, 27,28,29,31,35 41,44,42,46,44 1940? *BEG Louisville 01,02,03,04,05, 48,55,45,52,44, 06,09,16,17,22, 62,45,50,55,47, 26,33,34,37 47,54,55,53 1946? *U0C Texas City (Partially closed 1977) 1947 Goodyear Niagara Falls 08,10,11,20 46,51,46,55 1948 Firestone Pottstown 12 49 Uniroyal Painesville (closed 1975) 1950 Monsanto Springfield 32 51 (Closed 1975 1952 Dow Midland (No PVC since c 1975) BFG Avon Lake 118 54 1953 BFG Deer Park (Formerly Diamond) 1954 General Tire Ashtabula 136 56 (Closed 1984) | 1956 Air Products Pensacola Atlantic Refining Brooklyn(Closed late 1960s) Borden Leominster (Closed 1984) Conoco Hebronville (Closed 1975) BEG Niagara Great American Fitchburg 23 58 Plastics (Qosed 1983) Hooker Hicksville (Closed 1980-81) Pautosoto Passiac (Closed 1984) 1957 Atlantic Tubing Cranston (Closed 1967) Tenneco Flemington NJ 30 59 1958 Keysor Century Saugus, Chi 1960 BFG Watson, Cal Air Products Calvert City 38 [63 (closed March 1982 Re-opened Oeto'tjer 1983) Borden Illiopolis 1962 Tenneco Burlington NJ 1963 Conoco Aberdeen, Miss Stauffer Long Beach, Cal (Qosed 1982) 1965 Conoco ** Assonet, Mass (Qosed by Olin 1975 see below) Ethyl Baton Rouge (Qosed 1984) 1966 Georgia Gulf Delaware Qty (Formerly Dianond) General Tire/Pantas Mt Pleasant W Va (Qosed 1983) BEG Henry, 111 Stauffer Delaware City (Sold to Formosa 1983) 1967 Allied *** Painesville, 0 | (sold to Robintech) Hooker Burlington NJ 1968 Firestone Perryville (Qosed 1982) 1969 BFG Pedrickton NJ Goodyear Plaquemine Olin ** Assonet, Mass (Qossed 1975) (See a] >ove) (Formerly Conoco) 1971 Conoco Oklahoma City WPX/ASL_2 - LANGI0CASES.50 Continued GENC 008030 Page 46 TABLE 9 (Continued) USA PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP YEAR 1972 1973 COMPANY NAME Nat Starch Borden Roblntech *** 1974 1975 1979 1983 Atlantic Tubing/ Tallyrand Shintech Certain-teed Georgia Pacific Tenneco Firestone Formosa LOCATION Meredosia, 111 Springfield Painesville, 0 (sold to Georgia Pacific who converted to polystyrene) Cranston RI (Closec ASL CASE NUMBER 1982) Freeport, Tex Lake Charles Plaquemine, La Pasadena, Tex Plaquemine Point Comfort, Tex YEAR OF 1st EXPOSURE * My databank has no information on UCC before 1946 or BEG before 1950 ** Refers to same plant at Assonet ***Refer to same plant at Painesville. Allied plant never operated again for PVC after it was sold to Roblntech. NB Some of the plants in this list were closed down, some have changed ownership over the years, some have changed their product. WPX/ASL_2 - LANGIOCASES,51 GENC 008031 Page 47 TABLE 10 (Review date 1 January 1986) CANADIAN PVG PRODUCERS - START-UP DATES vs ASL CASES START-DP YEAR COMPANY NAME 1943 (1941?) Goodrich LOCATION Shawinigan ASL CASE NUMBER YEAR OF 1st EXPOSURE 01,02,03,04,05 44,43,41,45,44, 06,07,08,09,10 47,46,61,46,53 1951 Monsanto La Salle (Closed 1` '75) 1957 Goodrich Welland 1966 Esso Sarnia 1979 Diamond Shamrock Alb Fort Saskatchewan WPX/ASL_2 - LANG10CASES,52 GENC 003032 mmm Page 48 (Review dace l January 1986) TABLE 11 EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASL CASES START-UP COUNTRY NAME COMPANY NAME YEAR Pre 1939 East Germany State Company 1941 Russia State Comps 1950 Yugoslavia Jugo Vinil 1951 Czechoslovakia State Comps 1955 East Germany State Comps 1956 Rumania State Comps 1957 Poland State Comps Rumania State Comps 1958 1959 1961 1963 1965 1967 1969 1970 1972 1975 1976 1977 Rumania State Comps Hungary State Comps Rumania State Comps Yugoslavia Ohis Bulgaria State Comps Poland State Comps Russia State Comps Rumania State Comps Russia State Comps Yugoslavia Vinilplastika Czechoslovakia State Comps Russia State Comps Yugoslavia Hip Rumania State Comps LOCATION Schopau Vladimir et al Split Novaky Bitterfeldt Icechim Osweicim (Dwory) Tirnaveni Turda Risnov Berente Borsod Borzesti Skopje Varna Tarnow Djerjinsk Rimnicu Vilcea Volgograd Zadar Neratovice Kalush Area Pancevo Rimnicu Vilcea ASL CASE NUMBER 01,02,03,04 01,02 YEAR OF 1st Exposure 53,50,54,48 57,50 WPX/ASL 2 - LANGIOCASES,53 GENC 008033 (Review dace 1 January 1986) TABLE 12 JAPANESE PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP YEAR 1950 1951 1952 1951 1955 1956 1957 1960 1964 1966 1967 1968 1970 1971 1973 1974 COMPANY NAME Chisso Corp Kanegafuchi Rag Tekkosha Mitsui Toatsu Mitsubishi Mon Sumitomo Kag Denki Kagaku Nippon Zeon Toa Gosei Ryo-Nichi Nippon Zeon Nisshin Kagaku Kureha Kasei Shinetsu Kag Denki Kagaku Kanegafuchi Kag Chisso Corp Tokuyama Seksui San Arrow Kagak Sumitomo Kag Ryo-Nichi Shinetsu Kag Chisso Corp Denki Kagaku Kanegafuchi Kag Kawasaki Yuki Mitsui Toatsu Nissan Kagaku Shinetsu Kag Tekkosha Asahi Glass Toyo Soda 1975 1977 Central Kagaku Toyo Soda Unknown LOCATION Minamata Osaka Sakata Nagoya Yokkaichi Kikumoto Shibukawa Kambara Tckushima Uozu Takoaka Takeo Nishiki Naoetsu Ohmi Takasago Chiba Tokuyama Tokuyama Chiba Mizushima Tokuyama Mizushima Goi (Chiba) Kashima Kawasaki Sakai Chiba Kashima Yokkaichi Hayatsuki Sakata Yokkaishi Kawasaki Yokkaichi Kashima \ V ASL CASE NUMBER 01, 02 YEAR OF 1st EXPOSURE 53, 58 WPX/ASL 2 - LANGIOCASES,54 Page 50 (Review date 1 January 1986) TABLE 13 SOUTH AND CENTRAL AMERICAN PVC PRODUCERS START-UP COMPANY NAME YEAR 1953 Monsanto Mexica 1954 Policyd 1955 Geon Do Brazil 1956 Elchlor 1960 Electrochlor Viplastic 1961 Indupa 1965 (SOC Paramanga (1967 start up PET Columbiana 1966 Carburo De Col 1967 Plasticos Omega 1968 Primex 1970 Policasa Petro Dow 1971 Polimeros Mex 1975 Rico Chemicals 1976 Petroplas 1977 Indust Resistoc 1978 Huls Brasil Polychem Policyd 1979 PET Camacari LOCATION Lecheria (Mexico) Mexico City (Mexico) Sao Paulo (Brazil) Sao Caetano (Brazil) Capitan Bermudez(Argentina) Mendoz (Argentina) Cinco Saltos (Argentina) Paramonga (Peru) ) Cartagena (Colombia) Medellin (Colombia) Mexico Puebla (Mexico) Managua (Nicaragua) Conception (Chile) St Martin Puebla (Mexico) Guyanilla (Puerto Rico) EL Tablazo (Venezuela) Tlazcala (Mexico) Cubato (Brazil) El Salvador Coatzacoalcos (Mexico) Camacari Bahia (Brazil) ASL CASE NUMBER YEAR OF 1st EXPOSURE WPX/ASL_2 - LANGIOCASES,55 GENC. 008035 Page 51 (Review date 1 January 1986) TABLE 14 AUSTRALASIAN PVC PRODUCERS START-UP YEAR COMPANY NAME Mid 1950s ICI Australia 1960s B F Goodrich Late 1970s ICI Australia LOCATION Botany, Sydney Melbourne Laverton Melbourne ASL CASE NUMBER YEAR OF 1st EXPOSURE WPX/ASL 2 - LANGIOCASES.56 QENC 00SO36
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