Document oDMm2LGEdvjL2MadnYkRrxwME

October 3 1969 Dr. A. R. OIgbrow Chief of Reference Standards Section Reel due Che:;,Is try Branch . Division, of Fsaticidos Food and Drug Administration Washington, 1>. C. 20204 Dear Dr. Glasgow* Cno pound samples of our Aroclors 1254 and 1260 ore being fonrarded to you and to Mr. Vincent Sodlalc at the Atlanta Toxioological Branch today. Perhaps It will bo of interest to mention that In 1962 onu of our consulting laboratories uet&i-mincu the oral LDf>0 in I'ota of Aroclor 125*4 to l.o greater than 3 0 grama per kilogram when ad;*:iniotercd undiluted. using four groups of fixed sex animals weighing between 20J-253 grama and cdwinlotered at doses of 7*94. 10.0, 12.6, and 15.8 respectively for the Individual groups. Tho oral LD50 woo calculated as 11.9 gAs with limits of 10.47 to 13.45 gAs* In the casa of Aroclor 1260, a *>0# solution In corn oil developed data lending to a colcxxlotod L850 of 10.0 g/ks with lower and upper limits of 8.6 and 11.6 g/kg. I have enclosed summaries of recent data wo have received from Industrial Bio-Test Laboratories in Chicago. The summaries indicate the 90-day interim results of two year chronic feeding studies to dogs of Aroclor 1254 end 1200. A cccond enclosure is the summary showing the status of three generation rat reproduction studies on these materials begun in Kay. Ve also have underway two year oral studies in rats. Vo added 390 extra animals to this stuuy to allow sacrifice of same animals at three months, six months and one year. OSW 018423 STLCOPCB4004967 ? Dr. a. R. Qlosgow October 3> 1969 Page Two A verbal report on the 90 day sacrifices indicates that there were no measurable effects as indicated by the usuul parameters. A written interim report will be received whan the micro pathology has been completed. I have taken the liberty of sending a copy of this letter to you to Hr. Sedlak in the Atlanta Branch. Wo will be interested in learning of the results of your proposed toxicologicul testing. Sincerely, Elinor P. Wheeler Manager, Environmental Health EPWtju c.c. b.c. Jack D. Early Vincent Sodlak/ R. E. Keller W. R. Richard DSW 018424 STLCOPCB4004968