Document o9nMK4dLOkdZp2M0k8goBJLDR

Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 1 of 130 PAGEID #: 42305 EXHIBIT B IN THE UNITED STATES DISTRICT COURT SOUTHERN DISTRICT OF OHIO EASTERN DIVISION IN RE: E. I. DU PONT DE NEMOURS AND COMPANY C-8 PERSONAL INJURY LITIGATION This document relates to: ALL ACTIONS. CASE NO. 2:13-MD-2433 JUDGE EDMUND A. SARGUS, JR. MAGISTRATE JUDGE ELIZABETH P. DEAVERS DECLARATION OF JOHN M. GRAHAM, JR., M.D., SC.D. I, John M. Graham, Jr., declare and state as follows: 1. I prepared the Expert Report of John M. Graham, Jr., dated January 27, 2015 ("Expert Report"), and a true and accurate copy is attached as Exhibit 1. 2. Each of the opinions in the Expert Report is stated to a reasonable degree of scientific certainty, and was arrived at using reliable methods. 3. If called as a witness, I would testify competently to the matters stated in the Expert Report. 4. I declare under penalty of perjury under the laws of the United States of America that the foregoing is true and correct. Dated: March 30, 2015 John M. Graham, Jr. Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 2 of 130 PAGEID #: 42306 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER EXPERT REPORT OF JOHN M. GRAHAM, JR., MD, ScD Bartlett v E. I. du Pont de Nemours and Company Cause No. 2:13-cv-0170 and Wolf v E. I. du Pont de Nemours and Company Cause No. 2:14-cv-0095 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 3 of 130 PAGEID #: 42307 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER EXPERT REPORT OF JOHN M. GRAHAM, JR., MD, ScD 1.] I have been requested to review and comment on certain statements contained in the expert reports submitted by trial plaintiffs Carla Marie Bartlett and John Wolf, including the reports of Dr. Barry S. Levy (submitted 11/20/14) and Mr. Stephen E. Petty (submitted 12/6/14), that exposure to PFOA caused birth defects in two babies born to mothers who were occupationally exposed to perfluorooctanoic acid (PFOA, also termed C-8) at DuPont's Washington Works plant in West Virginia, and their assertions that exposure to PFOA is causally related to reproductive and developmental effects in humans including birth defects and low birth weight. 2.] I have reviewed information on the infant children of the two mothers, Karen Robinson and Darleen Sue Bailey, and the two mothers' occupational exposure to PFOA at the Washington Works plant. I have reviewed the scientific literature on PFOA, and on the unrelated anomalies seen in these two children. I have also reviewed factual material consisting of the mothers' deposition testimony and medical records and related material. I read reports authored by plaintiffs' experts, including Dr. Levy and Mr. Petty, specific to their opinions concerning claimed developmental health risks in humans allegedly caused by PFOA. 3.] Based on my review of these materials, as well as my extensive education, training and experience, and my research and publications, it is my opinion to a reasonable degree of medical and scientific certainty, using generally accepted practices in the fields of teratology, medical genetics, and epidemiology for establishing causality and applying them to the matters under dispute in this case, that: 2 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 4 of 130 PAGEID #: 42308 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER a.] Neither of the two reported anomalies was caused by exposure to PFOA, and one of the two reported anomalies was not a birth defect. b.] No association has been reliably documented in humans for PFOA and any birth, reproductive or developmental outcome. Also, there are no consistent associations between PFOA exposure and reproductive toxicity. c.] It was reasonable for DuPont to conclude that two children with unrelated and very different congenital anomalies, who were born in 1978 and 1981 to mothers who worked at DuPont, were, at best, case reports that were not statistically significant, did not demonstrate causation, and did not warrant further investigation, since none of the criteria for establishing a causal relationship between exposure to PFOA and adverse reproductive and developmental effects were met. 4.] My opinions are based on the information available to me as of the date of this report. To the extent new information becomes available, and/or plaintiffs' experts supplement their opinions, I reserve the right to amend or supplement my opinions. CREDENTIALS 5.] I am a board-certified pediatrician and medical geneticist, with almost 40 years of training and experience in clinical genetics, dysmorphology, teratology, developmental disabilities, communicative disorders, and birth defects. 6.] I completed a pediatric internship and residency, as well as fellowships in developmental disabilities and dysmorphology at Boston Children's Hospital and the University of Washington in Seattle, WA. During my dysmorphology training, I did original research on the teratogenic effects of alcohol, fetal constraint, and maternal hyperthermia. 3 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 5 of 130 PAGEID #: 42309 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER This work was published in peer-reviewed journals, and since that time, I have continued to publish on teratogenic syndromes, genetic syndromes, and other factors that cause birth defects. 7.] I was a steering committee member and co-founder of the David W. Smith Workshop on Malformations and Morphogenesis, which is a nationally recognized conference on the causes of birth defects, which has been held annually since 1980, and I continue to attend and advise organizers of this meeting on a yearly basis. I hold a Professor of Pediatrics Emeritus Lifetime Appointment at The David Geffen School of Medicine at UCLA, where I am on the UCLA Intercampus Medical Genetics Training Program Executive Committee. Beginning in 1988, I served as Director of Clinical Genetics and Dysmorphology at Cedars Sinai Medical Center (CSMC) in Los Angeles. I recently retired from this full-time position, but I continue to treat patients at CSMC and HarborUCLA Medical Center, and I teach genetics, teratology, embryology, and dysmorphology to medical students at UCLA and CSMC, as well as to residents and fellows in medical genetics, neonatology, and maternal fetal medicine. Between 1981 and 1988, I held similar positions at Dartmouth Medical School in New Hampshire. 8.] I am an academic clinical geneticist, who until recently saw about 500 outpatients per year and covered the inpatient medical genetics consultation service for a major part of the year (resulting in another 30-40 patients per year). My experience covers a wide variety of clinical problems, including craniofacial disorders, growth disorders, birth defects, intellectual disability, genetic conditions, and teratogenic disorders. Over the past 40 years, I have evaluated over 10,000 fetuses, infants, and children manifesting various 4 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 6 of 130 PAGEID #: 42310 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER birth defects, developmental disabilities, malformation syndromes, genetic diseases, and teratogenic disorders. 9.] I currently serve on the Section of Genetics and Birth Defects and the Section of Child Development for the American Academy of Pediatrics. I have served on the Editorial Boards for the following journals: Teratology, Birth Defects Research, American Journal of Medical Genetics, Congenital Anomalies (Japan), Annales de Gntique (France), European Journal of Medical Genetics, Global Pediatric Health, and Clinical Pediatrics. I am a past president of the Teratology Society, where I also served on the Council and other committees for many years. I have participated in Craniofacial Clinics and Spina Bifida Clinics, where I saw numerous children with birth defects in a multidisciplinary setting. I am a past president of the Society for Craniofacial Genetics. 10.] I have authored over 240 publications in peer-reviewed journals, as well as over 100 reviews and book chapters. I have been an investigator on numerous grants from a variety of organizations and governmental agencies dealing with intellectual disability and birth defects, and I have served as a medical advisor and lecturer for numerous support groups for families of children with various genetic syndromes. 11.] I have been a longstanding and active member of numerous professional organizations and academic societies concerned with the health of children and with the causes and prevention of birth defects, including the American Society of Human Genetics, European Society of Human Genetics, American College of Medical Genetics, American Board of Medical Genetics, American Academy of Pediatrics, Society for Pediatric Research, American Pediatric Society, Western Society for Pediatric Research, Teratology Society, and the Society for Craniofacial Genetics. 5 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 7 of 130 PAGEID #: 42311 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER 12.] My credentials, training, publications, and experience are more fully set forth in my Curriculum Vitae, which is in Appendix A. 13. ] A listing of previous legal matters where I have given deposition and/or court testimony during the past 4 years is in Appendix B. My fee for consulting is $500 per hour. 14.] The medical records, depositions, and literature I considered in this case are listed in Appendix C. I also relied upon the references cited in this report, as well as textbooks, guidelines, and general literature reviews that have been part of my years of experience and training. OPINIONS The Science of Birth Defects: Background Rates and Causes 15.] Every infant born in the U.S. has at least a 3% - 5% risk of being born with a major malformation or deformation, and an even higher risk (approximately 10%) of being born with internal anomalies or functional deficits that may not become apparent until later in life. In the past, the cause of most isolated congenital anomalies was unknown, with most malformations falling into the group of those defects with an unknown cause(s). It has previously been estimated that genetic causes (i.e., anomalies arising from alterations in genetic material) account for up to 25% of all human malformations (Beckman and Brent, 1999; Schardein, 2000). 16.] As we have learned more about the human genome and developed new techniques, the proportion of birth defects attributed to genetic causes has increased (Babkina and Graham, 2014). With genomic/genetic diagnostic techniques, up to 70-80% of patients with birth defects and developmental disabilities can receive a genetic/genomic 6 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 8 of 130 PAGEID #: 42312 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER diagnosis, 10% are attributed to environmental influences and maternal conditions, and only 10-20% continue to have an unknown etiology (Babkina and Graham 2014). 17.] There are numerous types of genetic alterations, the most common of which are mutations (changes to the DNA sequence of genes) and chromosomal defects (e.g., extra or missing chromosomes, or parts of chromosomes). Genetic alterations leading to malformations can be inherited, or can occur spontaneously due to random mutations of DNA. Genetically mediated malformations have never been found to result from exposure to any environmental agents. This is true even of those agents which have been shown to be affirmatively capable of causing damage to genetic material in individual cells, such as radiation. Environmental causes of human malformations (defined as any external influence to fetal development, i.e., not genetic) are thought to account for only 10% or fewer of all malformations (Brent, 2004). Scientists and medical professionals generally agree that most environmentally induced malformations are related to maternal disease states, such as infection, obesity, diabetes or alcoholism. While it has been well-understood in developmental toxicology for several decades that substances in a mother's blood can pass through the placenta to the fetus, it is estimated that only approximately 1% or less of all human malformations are related to exposures during pregnancy such as drug exposures, chemicals, or radiation (Brent, 2004). 18.] There are many relatively common syndromes that lead to fetal growth deficiency, but with the exception of fetal alcohol syndrome, the vast majority of these syndromes are genetic (Mortier, Graham and Rimoin, 2007; Graham, Burkhardt and Rimoin, 2013). The most common cause of intrauterine growth retardation is late gestational fetal constraint (Moh et al., 2012). The smaller the mother in relation to fetal 7 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 9 of 130 PAGEID #: 42313 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER size, the greater is the possibility of deforming uterine constraint in late fetal life. Deformations are more common in offspring born to small women than those born to larger women (Graham and Sanchez-Lara, 2015). This impact is readily evident in terms of birth size. Additional factors such as maternal smoking, alcohol use, diabetes, obesity, hypertension, and other maternal lifestyle variables and disease states can have a significant effect on birth size (Opitz et al., 1985; Cogswell and Yipp, 1995; Drooger et al., 2005) 19.] A birth defect can occur singly as an isolated defect, or multiple birth defects can also occur in one individual. When multiple birth defects, especially defects affecting varied organs and systems, appear together and are seen in different individuals in different families in a recurrent pattern or combination, they are generally accepted to have a common underlying cause, and are designated a birth defect syndrome, e.g., Down syndrome or fetal alcohol syndrome. As a particular pattern of defects or syndrome is seen in other patients, and as more is learned about a syndrome over time, initial descriptions are refined. Even with well-defined and refined syndromes, there is inherent variability in the manifestations of birth defect syndromes, both in type and severity of the various structural abnormalities that may appear. Patients with the same syndrome will manifest varying degrees of common core features, as well as occasional unusual or infrequent (but related) features. The purpose of syndrome identification and refinement is to enable clinicians to recognize these features as suggesting a specific condition, with a common underlying cause, natural history, and prognosis. 20.] There are two broad classes of birth defect syndromes, genetic and non genetic (or teratogenic). As stated above, genetic syndromes result from some change in 8 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 10 of 130 PAGEID #: 42314 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER the genetic material of the conceptus, occurring prior to or around the time of conception, while a non-genetic syndrome does not involve alteration of the genetic material. Genetic alterations generally occur in either the sperm or the egg, or both, prior to or at the time of conception. If there is an alteration in the genetic material of the sperm and/or the egg, when the sperm fertilizes the egg at conception, each cell that derives from that fused egg/sperm cell (i.e., each cell of the developing embryo) will carry that mistake. It is also possible that the genetic material of the sperm and egg could be "normal," but shortly (within hours, or at most days) after conception, a mistake occurs during cell replication. This type of cell replication error would result in "mosaicism," meaning that only some cells of the body will carry the error (i.e., those cells that derive from the cell where the error first took place). The term mosaic refers to the fact that some of the body's cells will carry the genetic error, and others will not. Even when such a mosaic genetic error occurs after conception, the error must occur shortly after conception, since after the first week there would be far too many cells without the mutation for manifestations of the genetic alteration to be apparent. 21.] Genetic disorders can also be inherited from the affected individual's normal parent(s). Within the 20,000-25,000 pairs of genes in the human genome, one member of each pair is derived from each parent. Because genes work in pairs, a person can have a working gene and a defective gene, and still be "normal." Usually the working version of the gene pair, where one gene is defective, allows that gene to perform its specific task (e.g., carriers for Tay-Sachs disease, cystic fibrosis, or Sickle Cell disease can be without the condition but carry the defective gene because it is only in one gene). 9 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 11 of 130 PAGEID #: 42315 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER 22.] These recessive genes in normal carrier parents only become apparent when the parents have a child with a recessive genetic condition. In that case, each parent has the same recessive gene, and the child inherits both non-working genes (i.e. one mutant gene from each parent). Autosomal recessive genetic conditions result when each normal parent, carrying one defective gene in a specific gene pair, each contributes this same defective gene to the conceptus, resulting in a complete lack of this gene's function in the conceptus. The recurrence risk for both parents to have a recurrence of such a condition is 25%. 23.] Dominant conditions result when there is one defective gene in a gene pair, and the normal member of that gene pair cannot complete a specific developmental task by itself. These dominant conditions usually result in a pattern of birth defects, a specific birth defect, or a risk for specific types of cancer because these genes affect developmental pathways or basic cell replication pathways. Once a person has a mutation in one of these genes, then their chance to pass it to an offspring is 50%. We know about the inheritance of dominant autosomal conditions from previous reports of such conditions being inherited in other families. (It is the job of a clinical geneticist to provide counseling for such conditions.) 24.] When such conditions appear for the first time in a family, they reflect a sporadic, new occurrence of this condition. In many instances, random or spontaneous mutations, or chromosomal errors, can lead to genetic birth defects and genetic birth defect syndromes. This is not uncommon. When neither parent has the dominant genetic problem seen in their child, it is termed a de novo (new) or sporadic occurrence. It is 10 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 12 of 130 PAGEID #: 42316 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER estimated that between 3.0 and 7.5% of all malformations in humans are the result of such fresh dominant mutations in genetic material (Nelson and Holmes, 1973). 25.] Preconception radiation and chemotherapy have the potential to produce germ cell mutations leading to genetic disease in the next generation. Dose-response relationships were evaluated between cancer treatments and genetic diseases in offspring in a case-cohort study involving 472 Danish survivors of childhood and adolescent cancer and their 1,037 pregnancies. No statistically significant associations were found between genetic disease in children and parental treatment with alkylating drugs or preconception radiation doses to the testes in male and ovaries in female cancer survivors. Thus mutagenic chemotherapy and radiotherapy doses to the gonads were not associated with genetic defects in children of cancer survivors (Winther et al., 2012). To the extent of our scientific knowledge at the current time, mutations leading to birth defects just happen in the normal course of cell division. There is one exception: paternal age. Advancing paternal age is associated with an increased risk for structural chromosomal defects and gene mutations in the male (Crow, 2006, Kong et al., 2012). It is commonly accepted that fresh dominant mutations occur more commonly in the sperm than in the egg. The testicle begins to age at age 30, and by age 40, most in vitro fertilization centers will discourage a man from donating his sperm. The Anomalies In Infants Born to Two Women Who Worked At the DuPont Washington Works Plant Are Not Associated With PFOA. 26.] Congenital anomalies in two children born to mothers who worked at the DuPont Washington Works plant are alleged by plaintiffs' experts Mr. Petty and Dr. Levy to be birth defects caused by their mothers' exposure to PFOA. There is no scientific evidence to support this claim. 11 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 13 of 130 PAGEID #: 42317 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER 27.] The mother of the first child worked in the Teflon Division at the Parkersburg, WV, DuPont Plant from approximately October 1977, until the spring of 1981. Her son was born on 7/15/78. At the time of birth, the child presented with a left epicanthal fold (an extra fold of skin over the inner corner of the eye). This fold temporarily occluded his tear duct on that side. It never required any surgery or created any functional problems. 28.] An epicanthal fold is considered a minor anomaly (a structural variation with no underlying surgical or medical significance), not a true birth defect. Epicanthal folds are normal findings in young infants with a flat nasal bridge, and they usually disappear with the normal growth of the nasal bridge, as it apparently did in this case (based on review of photographs from his mother's deposition). If the nose remains under-developed, epicanthal folds may persist, as they do in Down syndrome. Every person has several minor anomalies that result in the individual differences between people. They are not considered abnormal, and are not considered birth defects. The child's subsequent growth and development was normal. As discussed below, based on extensive testing in experimental animals (primarily rats and rabbits), there is no indication that PFOA is teratogenic or mutagenic (Case et al., 2001; Thibodeau et al., 2003; Butenhoff et al., 2004; Kennedy et al., 2004; Lau et al., 2006). In short, there is no good evidence this minor anomaly was caused by PFOA. 29.] The second mother worked at the Parkersburg, WV, DuPont Plant from 1978 through August 1986. During April or May of 1980, while pregnant, she began working in an area with the potential for PFOA exposure. She worked in that area for a total of three months only. Her son was born on 1/15/81. At the time of birth, the child presented with 12 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 14 of 130 PAGEID #: 42318 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER Bosma syndrome (diagnosis based on my many years of experience with this condition). He had a partial absence of his nose on the right (heminasal aplasia) and associated underdevelopment of his eye on that same side (colobomatous microphthalmia). 30.] This disorder is usually associated with absence of the nasolacrimal duct, occasional cleft palate, blocked nasal passages (choanal atresia), oro-nasal sensory deficits, and normal intelligence. This condition has been identified as Bosma syndrome (Graham and Lee, 2006). Some individuals with this condition also have hypogonadotropic hypogonadism (decreased hypothalamic stimulation from the base of the brain to the pituitary gland, resulting in underdevelopment of the gonads). Based on recurrence in two reported families (Lee and Graham, 2006), this disorder is thought to have a genetic basis, i.e., result from changes in DNA, with most cases representing fresh dominant mutations (as described in another section). The syndrome most likely occurred here because of a fresh dominant genetic mutation. If this child is fertile, his risk of passing this condition to future offspring could be as high as 50%. 31.] The child was treated by plastic surgeons at Johns Hopkins Hospital, and was evaluated by a clinical geneticist at Columbus Children's Hospital in Ohio. Again, based on extensive testing in experimental animals (primarily rats and rabbits), there is no indication that PFOA is teratogenic or mutagenic (Case et al., 2001; Thibodeau et al., 2003; Butenhoff et al., 2004; Kennedy et al., 2004; Lau et al., 2006). The best indication is that Bosma syndrome is the result of a genetic mutation. PFOA is not mutagenic (EPA 2005), and as discussed, it has not been shown that birth defects are caused by exposure of parents to mutagenic substances. 13 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 15 of 130 PAGEID #: 42319 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER Identification of Teratogens and Assessment of PFOA 32.] A teratogen may be defined as an agent that can produce a permanent abnormality of structure or function in an organism exposed during embryonic or fetal life. The identification of human teratogens requires careful interpretation of data obtained from several kinds of studies. The first suggestion that an agent might be teratogenic in humans often comes from clinical case reports. Case reports are more useful if they reveal a recurrent pattern of anomalies in children who experienced similar, well-defined exposures at similar points during embryonic or fetal development (i.e. a teratogenic syndrome). Case reports, however, cannot provide reliable quantitative estimates of the risk for anomalies in an exposed pregnancy. While case reports can be important in raising causal hypotheses, many hypotheses so generated prove to be incorrect. The coincidental occurrence of an environmental exposure in a pregnant woman and congenital anomalies in her child is very common, especially where the exposure or the anomalies are relatively frequent. 33.] Accordingly, case studies can be useful, but epidemiological studies provide the only means of obtaining quantitative estimates regarding the strength and statistical significance of associations between agent exposures in pregnant women and abnormalities in their children. Epidemiology is the study of disease and patterns of disease in human populations. Even with well-designed epidemiologic studies, however, one can never assume that a statistically significant association in a single epidemiologic study indicates causality, without other supporting evidence. Multiple epidemiology studies must demonstrate consistency with respect to the existence of an association between a particular exposure and a particular defect. 14 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 16 of 130 PAGEID #: 42320 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER 34.] In evaluating actual reproductive risks, scientists also rely on accurate determination of the dose of the agent, and on information obtained from animal studies. Epidemiologic studies must demonstrate consistency of the reproductive findings, and animal studies should be designed to add to the findings. In addition, in determining if an exposure is teratogenic, a conclusion must not contradict basic principles of teratology, genetics, and reproductive biology. Conclusions should be biologically plausible. In order to be considered a human teratogen, an agent should cause a specific pattern of malformations (a syndrome), and the biologic plausibility of the agent causing this pattern of malformations should be demonstrable in experimental animal systems, and understandable in terms of what we know about human morphogenesis. Among other things, it must be shown that the exposure to the potential causative agent preceded the manifestation of the adverse condition in time. 35.] Truly teratogenic exposures usually result in four different types of adverse reproductive outcomes: 1. Prenatal-onset growth deficiency, 2. specific patterns of malformation, 3. fetal loss, and 4. specific types of postnatal functional deficits, (most commonly neurodevelopmental defects) which comprise a recognizable teratogenic syndrome. Exposures to teratogens also follow a toxicological dose-response curve. There is a threshold exposure level, below which no effect will be observed. As the dose of the teratogen is increased above this threshold, both the severity and frequency of reproductive effects will increase. Unfortunately, some individuals assume that if a drug or chemical causes birth defects in an animal model or in an in vitro system at a high dose, then it will produce birth defects at any dose. This misconception may be reinforced by the fact that many teratology studies reported in the literature use several doses that are all 15 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 17 of 130 PAGEID #: 42321 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER high, and do not determine a no-effect dose. Ignoring the basic tenets of teratology appears to occur most commonly in the evaluation of environmental toxic exposures, where the potential exposure is often very low or unknown, and the agent has been reported to have some developmental effect, but only at a very high dose or a maternally toxic dose. Actual exposure to such substances in more typical circumstances is often orders of magnitude below a threshold dose, and not of concern. 36.] The period and frequency of exposure is also critical in determining what effects will be produced and whether any effects can be produced by a known teratogen. The actual period of development when severe malformations of major organs can be induced by environmental toxicants is from the 18th to the 40th day after conception, except for genitourinary tract development, closure of the palate, and histogenesis of the brain, which can all be affected later in development. Because of the totipotentiality of early embryonic stem cells, surviving embryos exposed to reproductive toxicants before organogenesis begins have a much greater potential for normal development, than when exposed later in development. The nature of embryonic development at this stage reflects the basic characteristic of the "all or none phenomenon," which is a propensity for embryos affected by teratogens to die, rather than survive as malformed embryos. 37.] Most teratogens produce a confined group of congenital malformations following exposure during the critical period of embryonic development. Even the most potent teratogenic agent cannot produce every malformation. While a group of malformations may suggest the possibility of certain teratogens, they cannot definitively confirm the causal agent. On the other hand, the presence of certain malformations can often eliminate the possibility that a particular teratogenic agent resulted in fetal harm, 16 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 18 of 130 PAGEID #: 42322 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER based on timing, or on alternate causes for the pattern of malformation (e.g., a recognizable genetic syndrome). As generally discussed above, there are accepted methods by which the scientific and medical communities assess whether a particular agent is a human teratogen. In considering whether there may be a causal relationship between a particular agent and a particular defect or syndrome, scientists generally look at the following criteria, referenced by, among others, (Polifka and Friedman, 1999; Brent, 2004; and Shepard, 2010: and Friedman and Hanson, 2013): Consistent findings of positive associations by 2 or more high-quality epidemiology studies; Proven exposure to the subject agent at critical times in prenatal development; Careful delineation of clinical cases with a specific defect or syndrome; Rare environmental exposure associated with a rare defect; Teratogenicity in experimental animals is important if it exists, but not sufficient in and of itself; The association should make biologic sense; and Secular trend analysis. 38.] Not all of these criteria must be established in order to prove a causal relationship between a particular agent and a particular defect or syndrome. However, most recognized causal relationships meet several of these criteria. Epidemiological Studies Fail to Demonstrate any Consistent Teratogenic Effect Associated With Exposure to PFOA 39.] There were no peer-reviewed and published epidemiologic studies indicating 17 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 19 of 130 PAGEID #: 42323 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER a consistent association between birth defects in humans and PFOA exposure at the time the two infants were born with disparate congenital anomalies to mothers working at DuPont's Washington Works plant in 1978 and 1981. This remains true, and was confirmed by the C-8 Science Panel in its 12/5/2011 Probable Link Evaluation of Birth Defects, which concludes that based on epidemiologic studies and other scientific data, there is not a probable link between exposure to PFOA (C8) and birth defects (C-8 Science Panel, Probable Link Evaluation of Birth Defects, 12/5/2011.) 40.] The Science Panel's conclusions were subsequently published in the peerreviewed literature. Stein et al. (2014) examined 10,262 live singleton or multiple births from 1990 to 2006, which were studied through the C8 Health Project focusing on a MidOhio River Valley community that was exposed to PFOA at varying levels through occupational exposure and through contaminated drinking water. They examined the association between estimated prenatal PFOA concentration and maternally reported birth defects (n=325) and found there was generally no association between estimated PFOA concentration and birth defects, with the possible exception of brain defects, but this observation was based on only 13 cases, which may represent a chance finding (according to the authors). In this same population, Darrow et al. (2014) performed a prospective study of miscarriage and found little evidence of association with serum levels of PFOA. 41.] Savitz et al. (2012a) estimated serum PFOA levels at the time of pregnancy for 11,737 pregnancies occurring between 1990 and 2006, based on historical information on PFOA releases, environmental distribution, pharmacokinetic modeling, and residential histories. Measures of association between PFOA and birth defects as well as miscarriage, preterm birth, and term low birth weight were close to the null in this study too. Savitz et 18 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 20 of 130 PAGEID #: 42324 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER al. (2012b) also studied 4547 birth records in this same study area from 1990 through 2004 and found no consistent evidence of an association between estimated PFOA exposure and stillbirth, pregnancy-induced hypertension, preterm birth, or indices of fetal growth. 42.] Residents drinking PFOA-contaminated water from the Little Hocking Water Association (LHWA) in Washington County, Ohio had mean serum PFOA levels significantly higher than those in the general U.S. population. Nolan et al. (2009) examined the birth weight and gestational age of infants born to mothers consuming water with either low or elevated PFOA levels. They found no differences in mean birth weight, gestation, incidence of low birth weight or prematurity, when infants exposed to elevated levels were compared with infants born to mothers drinking water with much lower PFOA levels. The serum PFOA levels in the high-exposure group were 8-50 times higher than the mid-range of those reported in the general population in some studies, while serum PFOS levels were similar to the general population in both groups. Nolan et al. (2010) compared birth weights and gestational ages of neonates born to mothers residing in zip codes with water service provided completely, partially or not at all by the LHWA. The incidence of low birth weight, preterm birth, mean birth weight and mean gestational age of neonates did not significantly differ among water service categories. Markedly elevated PFOA exposure, as categorized by water service category, was not associated with increased risk of lowered birth weight or gestational age. 43.] Nolan et al. (2010) expanded the scope of their analysis to examine the associations between PFOA, congenital anomalies, labor and delivery complications and 19 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 21 of 130 PAGEID #: 42325 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER maternal risk factors. They concluded that PFOA was not associated with an increased risk of congenital anomalies, most labor and delivery complications and maternal risk factors. 44.] Other studies of the same population have reported similar results, with little to no reported evidence of association between maternal serum levels of PFOA and preterm birth, low birth weight, or miscarriage (Darrow et al., 2013; Stein et al., 2009) or impaired childhood neuropsychological functioning and behavioral impacts (Stein and Savitz, 2011; Stein et al, 2013; Stein et al., 2014). In short, no consistent reproductive effects have been shown in these Mid-Ohio River Valley epidemiological studies, nor do more highly exposed worker populations show more severe or more frequent effects than populations exposed to lower levels. 45.] Additional studies also have confirmed that there are no consistent associations between serum fluorochemical levels (either PFOS or PFOA) in exposed workers and adverse birth outcomes (Lau et al., 2007). Among exposed female workers at a Decatur, Alabama facility where PFCs were manufactured, and their serum PFOS concentrations were many orders of magnitude higher than those measured in the general population, self-reported median birth weight was well within normal range at 3.39 kg. Furthermore, birth weight failed to correlate with high or low exposure to PFOS and PFOA, based on where the mothers worked (Grice et al., 2007). On the other hand, maternal smoking was found to be associated with reduced birth weight in this population. Smoking is known to have a negative effect on size at birth, and if PFOA had a similar effect, it should have been picked up by this study. An initial study of health insurance claims among more highly exposed female workers in this same worker population demonstrated no 20 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 22 of 130 PAGEID #: 42326 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER significant increased risks for birth defects, infertility, pregnancy complications, prematurity, or perinatal complications (Olsen et al., 2004). 46.] Likewise, additional epidemiological studies of groups within the general population have shown no consistent associations between serum PFOA levels and adverse birth outcomes, including reduced birth size (Fei et al., 2007; Monroy et al., 2008; Washino et al., 2009); preterm birth, low birth weight, or small for gestational age infants (Chen et al., 2012); impact on developmental milestones (Fei et al., 2008); or childhood growth at age 7 years (Andersen et al., 2013). 47.] Moreover, the magnitude of the reductions in birth weight reported in the general population studies were inconsistent and quite small, so it is unlikely to have any clinical significance. These studies do not establish any association between PFOA and intrauterine growth retardation or abnormalities in postnatal growth and development. Since the most common cause for reductions in birth weight is late fetal constraint (Graham and Sanchez-Lara, 2015), any factor that increases the potential for fetal constraint could decrease birth size, without having any real biologic significance. Only permanent reductions in birth size, such as those seen with fetal alcohol syndrome, would be likely to have true biological significance. 48.] Collectively, the epidemiologic studies of diverse population samples are most notable for the inconsistency in their findings. The study by Nolan et al. (2009) looked at a more highly exposed population found no association between reduced birth weight and PFOA exposure. The general population studies were dealing with serum levels of PFOA between 1-6 ng/ml, while the Nolan et al. study dealt with serum PFOA levels approximately 9-10 times higher at 50 ng/ml. With no adverse results reported more 21 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 23 of 130 PAGEID #: 42327 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER highly exposed populations (Grice et al, 2007; Nolan et al., 2009), and inconsistent birth weight associations in the general population, it cannot be said that these studies, considered as a whole, show a causal link between birth weight and PFOA levels. 49.] In sum, as documented above, PFOA exposure has been thoroughly studied over the years, and there is no consistent association between PFOA exposure during pregnancy and birth defects, miscarriages, and pregnancy complications (prematurity, low birth weight, stillbirths). Exposure at Critical Times During Prenatal Development to a Specific Agent 50.] Because teratogenic agents disrupt normal cell functions and/or development by specific mechanisms, exposure to an agent at certain times during development may produce a harmful effect, while exposure at other times during development will not. The concept that a teratogenic exposure needs to occur during the critical period when a developing organ or structure is susceptible to the mechanisms of action of a particular agent in order to cause a malformation of that organ or structure has been accepted in medicine since the early 1960s, when a high frequency of limb malformations was associated with the ingestion of thalidomide, but only when ingested during early gestation, when the limbs were forming. As discussed above, epidemiology studies of PFOA do not demonstrate any increase in adverse reproductive health effects, such as birth defects, intrauterine growth retardation, or prematurity. Therefore, the studies support that exposures to PFOA during the period of organ development do not compromise the development of any structures or significantly impair fetal growth. 22 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 24 of 130 PAGEID #: 42328 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER No Delineation of Clinical Cases 51.] Identification of a human teratogen requires careful interpretation of data obtained from several kinds of studies. The first suggestion that an agent might be teratogenic in humans often comes from published reports of isolated clinical cases (i.e., case reports). While such case reports may generate hypotheses and trigger further investigation, they are generally not considered evidence of causation. In fact, most hypotheses generated by such case reports ultimately prove to be incorrect. As discussed in more detail above, two children with congenital anomalies who were born in 1978 and 1981 to mothers who worked at DuPont are, at best, case reports, that do not demonstrate causation, and did not warrant further investigation at the time. These case reports are emphasized on pages 7 and 8 of Mr. Stephen E. Petty's report as purported evidence that C8 caused birth defects in offspring born to exposed workers. Dr. Levy extends this speculation on pages 9 and 10 of his report, by citing unpublished work by 3M that suggested C-8 might cause eye defects in unborn rats, whose mothers were fed C-8 during pregnancy. 52.] The rat study cited by Dr. Levy and Mr. Petty were discredited when these experiments in pregnant rats were repeated in multiple studies in rats and a study in rabbits and the fetuses exposed to C-8 did not have any birth defects (US EPA, Office of Pollution Prevention and Toxics, Risk Assessment Division, "Draft Risk Assessment of the Potential Human Health Effects Associated with Exposure to Perfluorooctanoic Acid and its Salts," Jan. 4, 2005). The replication of experiments to duplicate findings is a basic principal of science that is ignored by both Mr. Petty and Dr. Levy in their reports. In addition, upon further review at the time, it was concluded that what was initially interpreted as eye 23 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 25 of 130 PAGEID #: 42329 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER defects was actually an artifact from how the tissue slides were prepared. (US EPA, Office of Pollution Prevention and Toxics, Risk Assessment Division, "Preliminary Risk Assessment of the Developmental Toxicity Associated with Exposure to Perfluorooctanoic Acid and Its Salts," Apr. 10, 2003). 53.] Moreover, there is no biologic relationship linking the minor anomaly, which affected one child (not a birth defect), with the birth defect syndrome (Bosma syndrome), which affected the other child. The conditions in these two individuals are not alike. Furthermore, the literature on PFOA does not suggest this compound causes either of these conditions or any other specific type of birth defect in humans. In addition, subsequent studies have shown that there is no association between birth defects and PFOA exposure (Stein et al., 2014). 54.] The animal data regarding developmental effects and PFOA and PFOS, cited by Dr. Levy and Mr. Petty, are not relevant to human exposures in the Mid-Ohio River Valley. These animal studies involved huge doses of these compounds, which are not relevant to the population exposures around the DuPont facility in West Virginia. The general population studies report the mid-range of serum levels of PFOA between 1-6 ng/ml, while the Nolan et al. study involved serum PFOA levels about 9-10 times higher at 50 ng/ml. The mean of the serum PFOA level for women aged 20-39 years in the C8 Health Project was 42.3 ng/ml, and the median was 17.0 ng/ml (Frisbee et al., 2009). 55.] By contrast, doses of PFOA used in the rat studies by Butenhoff et al. (2004) resulted in estimated serum concentrations of 32,000-59,000 ng/ml, and for the mouse studies by Lau et al. (2006), the estimated serum concentrations were 15,740-59,550 24 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 26 of 130 PAGEID #: 42330 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER ng/ml. Thus, the doses of PFOA used to study toxic effects in animals have been many thousand-fold higher than human exposures, and do not see any effects at all. 56.] Mr. Petty criticizes DuPont on page 12 of his report, indicating that the company "was ignoring the known data about human birth defects in their own workers from 1981." Mr. Perry acknowledges that based on 4 developmental studies in laboratory animals, DuPont concluded on 2/29/88 that "C-8 is not considered a developmental hazard." Those and other early studies showed that PFOA was nongenotoxic and nonteratogenic (Case et al., 2001; Thibodeau et al., 2003; Butenhoff et al., 2004; Kennedy et al., 2004, Lau et al., 2006). Thus, the statement that "C-8 is not considered a development hazard" was true in the 1980s, as it remains true today. 57.] Dr. Levy also indicates on page 38 of his report that DuPont should be faulted for not undertaking pregnancy outcome studies in their own employees after two children were born to exposed workers with different anomalies in 1978 and 1981. Dr. Levy ignores the fact that, as discussed, these two defects were not medically related to one another and that the results of the initial animal studies were not replicated in at least three studies that followed. While these additional studies were pending, DuPont made every effort to avoid exposing pregnant workers to high levels of C-8 by moving them to different areas. Further, as testified by Dr. Bruce Karrh, DuPont's corporate medical director at the relevant time, DuPont investigated the two anomalies (one confirmed and unconfirmed) and determined that they were not related to PFOA exposure. There was no scientific reason after the conclusion of the follow up developmental toxicity studies in 1982 to believe that exposure to PFOA could cause developmental defects. Moreover, additional studies were performed that confirmed that PFOA was not teratogenic or 25 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 27 of 130 PAGEID #: 42331 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER genotoxic (Case et al., 2001; Thibodeau et al., 2003; Butenhoff et al., 2004; Kennedy et al., 2004, Lau et al., 2006). 58.] On page 38, Mr. Petty also criticizes DuPont for not initiating a pregnant worker epidemiology study. Mr. Petty's criticism is incorrect for the same reason that Dr. Levy is incorrect. Moreover, over the past 25 years (1990-2006), such studies of pregnancy outcomes throughout the exposed Mid-Ohio River Valley have been carried out in a thoroughly scientific manner, and they have confirmed that there is absolutely no indication that PFC exposure causes birth defects. 59.] On page 28 of his report, Mr. Petty criticizes a 3/15/02 DuPont media release for stating that "C-8 is not a developmental toxin (it does not cause birth defects)," claiming that data from 1981 suggested otherwise. As discussed above, the statement by DuPont was true in 2002, and it remains true today. 60.] On page 65 and 66 of his report, Mr. Petty again mentions the initial flawed study by 3M regarding a preliminary finding of C-8 treatment-related damage to fetal rat eye lenses. As discussed above, however, these results are irrelevant because they could not be replicated, and were determined to be an artifact of how the slides were prepared. Thus the disparate anomalies in Robinson and Bailey do not suggest a teratogenic syndrome, and the animal studies fail to confirm that any malformations or patterns of defects are caused by exposure to PFOA. No Rare Environmental Exposure Associated with a Rare Defect 61.] PFOA exposure is relatively ubiquitous in the general population. As discussed above, more heavily exposed individuals do not report any increased incidence 26 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 28 of 130 PAGEID #: 42332 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER of birth defects, or other adverse developmental effects. The two anomalies cited by the plaintiffs' experts were not rare defects associated with rare environmental exposures. Animal Studies Do Not Demonstrate a Specific Birth Defect Syndrome 62.] Experimental animal studies sometimes provide a means of identifying agents with teratogenic potential, but a positive animal study is not and should not be considered proof that an agent is teratogenic in humans. It is not appropriate to directly extrapolate positive findings in animals to humans for purposes of determining causation, due to the numerous differences between species. These differences include, among others, differences in placentation, metabolism and embryonic development. Moreover, experiments in animals often employ dosages that are many times greater than those likely to occur in humans, and toxic effects to the animal mother being dosed may impact the fetus and confound the interpretation of fetal outcome (that is, where an animal mother becomes ill due to some exposure at a very high dose, it is difficult to determine whether any fetal effects are due to the mother's illness or a toxic effect of the agent at issue). 63.] With these caveats in mind, I have reviewed the available animal literature on PFOA, and no specific birth defects syndrome has been shown to result from exposures to PFOA. Teratological studies in the rat, rabbit and mouse with PFOA and related compounds from the 1980s forward have been reassuring that PFOA does not cause birth defects (Case et al., 2001; Thibodeau et al., 2003; Butenhoff et al., 2004; Kennedy et al., 2004, Lau et al., 2006). It is also well accepted that experimental animal studies using huge doses that are not experienced by humans can't be considered proof that an agent is teratogenic in humans at much lower doses. Thus, this factor is not met. 27 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 29 of 130 PAGEID #: 42333 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER No Biologic Plausibility 64.] Any purported causal association needs to make biologic sense, but there is no clear biologic mechanism that would support any association between PFOA and birth defects, or other endpoints of reproductive toxicity. Abbott et al. (2007) studied PFOAinduced developmental toxicity in the mouse and found that postnatal lethality, deficits in postnatal weight gain, and delayed eye opening were all dependent on expression of the peroxisome proliferator-activated receptor alpha, a developmental pathway, as is the development of PFOA-induced liver tumors in rats (Kennedy et al., 2004). Like many other metabolic differences between humans and rodents, this pathway is not relevant to humans (EPA 2005). PFOA exposure does not affect maternal weight gain or fetal resorption in mice, and these effects appear to be independent of PAPR alpha activity. Darrow et al. (2014) found no association between PFOA levels and miscarriages, and there is clearly no association between PFOA exposure and intrauterine growth restriction. No Secular Trends 65.] Secular trend analysis looks at disease trends following the increasing usage of some agent in large populations. The classic example of secular trend analysis is the appearance of phocomelia (a birth defect in which the extremities are either shortened or missing) in geographic regions where there was increased Thalidomide usage. The appearance of this rare defect triggered an investigation that eventually led to the discovery of the teratogenicity of Thalidomide. There has been no demonstrated increase in the frequency of Bosma syndrome, the birth defect syndrome seen in one of the two children of DuPont workers cited by the plaintiffs' experts, or any other syndrome or 28 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 30 of 130 PAGEID #: 42334 EXHIBIT 1 SUBJECT TO PROTECTIVE ORDER anomaly, with occupational exposure to PFOA, or with the current ubiquitous low-level exposures to PFOA. Thus, this factor is not met. CONCLUSIONS 66.] In summary, based on the foregoing, to a reasonable degree of medical certainty, there is no relationship between the anomalies seen in the children of the two DuPont workers and their mothers' exposure to PFOA, nor was there sufficient indication of a birth defect syndrome or other pattern of adverse reproductive outcomes associated with PFOA exposure at the time the anomalies were reported to warrant further investigation by DuPont. Furthermore, as confirmed by many additional studies in the following years, existing scientific data even today do not demonstrate any cause for concern from a reproductive or developmental standpoint over low levels of exposure to PFOA. Even before these studies were completed, there was no scientific evidence to suggest the exposure to PFOA was teratogenic, and the C-8 Science Panel has now confirmed that this previous understanding is correct. I reserve the right to supplement these opinions as additional information becomes available. I also reserve the right to comment on any additional opinions of the Plaintiffs' experts. John M. Graham, Jr., MD, ScD: Dated: 1/27/2015 29 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 31 of 130 PAGEID #: 42335 appendix a Jo h n M. Gr a h a m , Jr ., M.D., Sc .D. CURRICULUM VITAE Date o f Birth March 8, 1947 Place o f Birth Wilmington, DE, USA Business Address BEFua-mxsianiel ss Phone BOARD CERTIFICATIONS 1982 1982 1993 EDUCATION Medical Genetics Institute Cedars-Sinai Medical Center 8700 Beverly Blvd, PACT Suite 400 Los Angeles, CA 90048 310-423-9909 310-423-9752 john.graham@cshs.org American Board of Medical Genetics (No. 1176) American Board of Pediatrics (No. 039677) American College of Medical Genetics (Founding Fellow) 1969 B.A., Natural and Behavioral Sciences Johns Hopkins University 1975 M.D., Medicine 1981 Sc.D., Public Health Administration and Communicative Disorders POSTGRADUATE TRAINING Medical University of South Carolina Johns Hopkins University School of Hygiene and Public Health Pediatric Intern - Children's Hospital Medical Center, Boston MA, 1975-76. Pediatric Resident - Children's Hospital Medical Center, Boston MA, 1976-77. Fellow in Developmental Disabilities with Dr. Allen Crocker, Children's Hospital Medical Center, Boston, MA, 1977-78. Fellow in Dysmorphology with Dr. David W. Smith and Instructor in Pediatrics, University of Washington, School of Medicine, Seattle WA, 1978-80. PROFESSIONAL EXPERIENCE Consultant Pediatrician and Medical Geneticist, Harbor-UCLA Medical Center, Teaching Appointment, Torrance CA 2014-present Printed January 28, 2015 - Page 1 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 32 of 130 PAGEID #: 42336 EXHIBIT 1 Director, Division of CSMC Clinical Genetics and Dysmorphology, retired 6/30/13 1988-2013 Director, CSMC Medical Genetics Birth Defects Center Outpatient Facility, retired 6/30/13 1988-2013 Director Clinical Training, CSMC Medical Genetics Training Program, retired 6/30/13 1990-2013 Director, CSMC Craniofacial Clinic, 1990-2005 Director, CSMC Fetal Dysmorphology/Pathology Service, 1990-2000 Cedars-Sinai Medical Center, Los Angeles, CA Co-Director, CSMC Prenatal Diagnosis Center, 1988-1993 Associate Professor of Pediatrics in Residence, U CLA School of Medicine 1988-1990 Professor of Pediatrics in Residence, U CLA School of Medicine, Los Angeles, CA 1990-2013 Step I, 1990-1993; Step II, 1993-1996; Step III, 1996-1999; Step IV, 1999-2002; Step V, 2002-2005; Step VI, 2005-2008; Step VII, 2008-2011; Step VIII, 2011. Professor Emeritus in Pediatrics, David Geffen School of Medicine at U CLA Lifetime Appointment Professor of Pediatrics and Biomedical Sciences, CSMC 2010-2013 Director of Clinical Genetics and Dysmorphology Program, 1981-1988 Dartmouth Medical School, Hanover, NH. Medical Director of New Hampshire Genetic Services Program, 1981-1988 Bureau of Special Medical Services, Division of Public Health Services, Concord, NH. Assistant Professor of Maternal and Child Health, 1981-1986 Associate Professor of Maternal and Child Health, 1986-1988 Adjunct Professor of Maternal and Child Health, 1988-1998 Dartmouth Medical School, Hanover, NH. MEDICAL LICENSURE 1977 1978 1980 1980 1988 Massachusetts (Certificate No. 40798), inactive Washington (Certificate No. 16789), inactive Vermont (Certificate No. 6590), inactive New Hampshire (Certificate No. 6276), inactive California (Certificate No. G64797), active PROFESSIONAL ACTIVITIES AND COMMITTEES Steering Committee Member and Co-Founder, David W. Smith Morphogenesis and Malformations Workshop, 1980-2012. Steering Committee Member, New England Regional Genetics Group, 1981-1988. Chairman, Health Professional Advisory Committee, NH Chapter, March of Dimes, 1985-1988. Member, Section on Child Development, American Academy of Pediatrics, 1986-present. Member, Section on Genetics, American Academy of Pediatrics, 1995-present. Member, American Society of Human Genetics Information and Education Committee, 1986-1990. Member, Social Issues Committee of the American Society of Human Genetics, 1991-1993. Printed January 28, 2015 - Page 2 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 33 of 130 PAGEID #: 42337 EXHIBIT 1 Chairman, American Society of Human Genetics Task Force on Teaching Human Genetics in North American Medical Schools, 1988. Chairman, Genetic Services Triage Committee, Cedars-Sinai Medical Center, 1988-2013 Co-Chairman, Prenatal Diagnosis Case Review Conference, Cedars-Sinai Medical Center, 1988-1993. Chairman, Medical Genetics Educational Mission Planning Task Force, Cedars-Sinai Medical Center, 1990-2013. Chairman, Clinical Genetics Review Conference, Cedars-Sinai Medical Center, 1988-present. Member, Review and Appraisal Committee, Department of Pediatrics, U CLA School of Medicine, 1989-1992 and 1999-2002 Co-Chairman, Year 2 Course on Medical Genetics (Genetics 201), 1989-1993, Chairman, Genetics 201 Planning Committee, U CLA School of Medicine, 1991-1993. Executive Committee, U CLA Intercampus Fellowship Training Program in Medical Genetics, l9912013. Chairman of Genetics Curriculum Working Group, Curriculum Review Subcommittee, Medical Education Committee, U CLA School of Medicine, 1991-1993. Chairman, Cedars-Sinai Medical Center Department of Pediatrics Course on Human Genetics, 1988 2013. Member, Pediatric Advisory Committee, Cedars-Sinai Medical Center, 1988-1990. Bioethics Committee, Cedars-Sinai Medical Center, 1990-1996. Southern California March of Dimes Health Professional Advisory Committee, 1991-1994. Liaison to American Society of Human Genetics from Teratology Society, 1990-2002; Liaison to Dysmorphology Societies (U.K., Europe, U.S.A.) from Teratology Society, 2002-2013. Teratology Society, Publications Committee, 1989-1995; 2011-2012; Public Affairs Committee, 1997 2000; Finance Commitee 2010-2012; Education Commitee 2010-2012; Program Commitee 2010-2012, Council, 2002-2005; 2009-2013; Vice President Elect, 2009-10; Vice President 2010-11; President 2011-12. Dysmorphology Sub-Committee, Clinical Practice Committee, American College of Medical Genetics, 1993-97. Consulting Developmental Pediatrician, U CLA University Affiliated Program, 1995-1999. President, Society of Craniofacial Genetics, 1998-2000. Printed January 28, 2015 - Page 3 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 34 of 130 PAGEID #: 42338 EXHIBIT 1 Member of Gorlin Dysmorphology Meeting Organizing Committee, 1999-2005. Guest Editor, American Journal of Medical Genetics, Special Issue on Gastrointestinal Disorders, 122A:281-353, November 1, 2003. Guest Editor, European Journal of Medical Genetics, Special Issue on Epilepsy and Genetics, European Journal of Medical Genetics, 55(5): 279-280, 2012. Guest Editor, European Journal of Medical Genetics, Special Issue on Genetics of Common Malformations, European Journal of Medical Genetics, January 2014. Associate Editor of Clinical Teratology, Teratology, 1983-87, and 1989-95. Editorial Board Member, Annales de Gntique (France), 2000-2004. Editorial Board Member: Clinical Pediatrics, 1983-present. Editorial Board Member, American Journal of Medical Genetics, 1995-2001; 2009-present Editorial Board Member, Congenital Anomalies (Japan), 2000-present Editorial Board Member, European Journal of Medical Genetics, 2004-present. Editorial Board Member, Global Pediatric Health, 2014-present. International Advisory Board for Indian Academy of Medical Genetics, 2012-present Cedars-Sinai Medical Center Internal Review Board Committee, 2001-2004, 2010-2013. SCHOLARLYSOCIETIES AND PROFESSIONAL ASSOCIATIONS American Society of Human Genetics European Society of Human Genetics American College of Medical Genetics American Board of Medical Genetics Society of Craniofacial Genetics Society for the Study of Behavioral Phenotypes International Society for Prenatal Diagnosis American Cleft Palate-Craniofacial Association American Academy of Pediatrics Society for Pediatric Research American Pediatric Society Western Society for Pediatric Research European Society of Pediatric Research Teratology Society HONORS AND SPECIAL A WARDS Distinguished Accomplishment, National Youth Science Center, Nasson College, Springvale ME, 1964. Printed January 28, 2015 - Page 4 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 35 of 130 PAGEID #: 42339 EXHIBIT 1 First Place in Zoology, International Science Fair, St. Louis MO, 1965. First Place, 7th Annual Student Research Competition, Medical University of SC, Charleston SC, 1972. First Place, 8th Annual Student Research Competition, Medical Univ. of SC, Charleston SC, 1973. Gold Medal and Grand Award, Student A.M.A. Squibb Scientific Exhibit Competition, National Student Research Forum, Galveston TX, 1973. Alpha Omega Alpha Honorary Medical Fraternity, 1973, Lange Award for Scholarship and Student Community Service, 1973, Medical University of South Carolina, Charleston SC. Gold Medal, Student A.M.A. Squibb Scientific Exhibit Competition, National Student Research Forum, Galveston TX, 1974. Mosby Scholarship Book Award for Scholastic Excellence, Medical Univ of South Carolina, 1974 and 1975. Poncin Scholarship Award, University of Washington School of Medicine, Seattle WA, 1979. Certificate of Appreciation, United Leukodystrophy Foundation, 1986. Saul Blatman Clinical Scholar Award (1986), and Saul Blatman Excellence in Teaching Award (1987), Department of Maternal and Child Health, Dartmouth Medical School. Award for Excellence in Education, U CLA School of Medicine, Los Angeles CA, 1993. Elected to Delta Omega, Honorary Public Health Society, Alpha Chapter, Johns Hopkins University, School of Hygiene and Public Health, 1994. CSMC Medical Genetics Institute Paper of the Year Award: Mutations in the gene encoding filamin B disrupt vertebral segmentation, joint formation and skeletogenesis. Nature Genetics, 36:405-410, 2004. Awarded 4/28/04. Scroll of Appreciation from Brigadier General of the European Medical Command for CME lectures given to U.S. Army medical service providers, 5/21/09 Thank You Doctor Award from ALO Cultural Foundation for service to Lebonese Boy with Fraser Cryptophthalmos Syndrome, June 2009. Listed by U.S. News and World Report as being among the best doctors and in the top 1% of Clinical Geneticists in the U.S.A. in 2012. Cedars-Sinai Medical Center Golden Apple Award for Excellence in Teaching Medical Genetics, June 2012. Cedars-Sinai Medical Center, Medical Genetics Institute, Lifetime Achievement Award in Recognition of Extraordinary Achievement in Teaching and Mentoring, June 27, 2013. Printed January 28, 2015 - Page 5 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 36 of 130 PAGEID #: 42340 EXHIBIT 1 PREVIOUS AND CURRENT GRANTSAND CONTRACTS "The role of maternal hyperthermia as a teratogen-potentiating factor." 4/1/81-3/25/83: $4000.00. BRSG Grant 2S07-RR05392-21, 6/10/82-7/1/83: $1000.00, Hitchcock Foundation Research Project #51(PI) "Investigation into the biochemical and genetic basis for X-linked ocular albinism." 4/1/86-3/31/87: $5000.00. Gilman Fund. (PI) "Investigation into the molecular basis of Beckwith-Wiedemann syndrome." 6/1/8512/31/86: $500 Hitchcock Foundation; $1000 March of Dimes Research Program; $3000.00 BRSG Grant 2S07RR05392-25, 4/1/87 - 3/31/88. (PI) "New Hampshire Genetic Services Program." 2/1/81-6/30/88: $283,117.00. New Hampshire Bureau for Special Medical Services, New Hampshire Division of Public Health Services. (PI) "Multidisciplinary care for children with birth defects and inherited disorders that cause developmental disabilities." 7/1/86-6/30/89: $211,772.00. Jessie B. Cox Charitable Trust Development Program. (CI) "Genetic counseling learning system: Part 1. Down syndrome, Part 2. Spina bifida." 10/1/87- 9/30/88: $13,200.00, New England Regional Genetics Group Special Project. (PI) "Collaborative medical and developmental support services project for children with genetic and prenatally determined disorders." 10/1/88 - 9/30/91: $368,062.00, U.S. Department of Education, Bureau of Special Education and Rehabilitative Services. (CI) "California AFP Screening Program Prenatal Diagnosis Center Follow-Up" Contract No. 88-93587. 7/1/88 - 6/30/92: $440,111.00, California Department of Health Services. (Program Director) Vendorized contract after 6/30/92. "Longitudinal follow-up in 15 probands with Beckwith-Wiedemann syndrome." 5/23/92-8/31/92: $2,000.00, March of Dimes Summer Science Research Program for Medical Students (recipient Ms. Elaine Weng), U CLA Medical School, Class of 1995): #8-FY9280. (PI) plus Short Term Training Program Summer Research Grant: 5/24/93-8/13/93, $2,700.00, U CLA School of Medicine. "Mosaic chromosome aneuploidy diagnosed prenatally: a prospective study." 1/1/94-6/30/94: $14,325. Feintech Foundation. (CI) "Pallister Hall syndrome: genetic linkage studies", 10/1/94-9/30/95: $5,000. NIH National Center for Human Genome Research. Consulting Geneticist and Developmental Pediatrician, U CLA University-Affiliated Program (MCH Grant): 1995-1999; total contractual award $68,000. The Incidence and Prevalence of CHARGE Association/Syndrome. Canadian Pediatric Surveillance Program (10/1/01-9/30/04). Kim Blake (PI), John Graham (CI). Printed January 28, 2015 - Page 6 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 37 of 130 PAGEID #: 42341 EXHIBIT 1 The Incidence and Prevalence of CHARGE Association/Syndrome. Kim Blake (PI), John Graham (Consultant). Start-up grant for $10,000 from CHARGE Syndrome Foundation (2001). E. A. Baker Foundation (Canadian National Institute for the Blind) $23,000, The Incidence and Prevalence of CHARGE Association/Syndrome. Kim Blake (PI), John Graham (CI). (2002-2003). Genesis Fund Grant for CSMC Craniofacial Clinic for $25,000 (2003), John Graham (PI) Boston MA. Larsen Syndrome Grant from National Organization for Rare Diseases, $30,000, 10/1/03-9/30/04. John Graham (PI) Danbury CT. CSMC Infant Progress Clinic; Contract for 20% salary to provide developmental and dysmorphology follow-up services toNICU graduates: (7/1/01-6/30/06). CSMC Telepsychiatry Grant for Outreach Services; CADept of Developmental Services, Sacramento CA, Contract for 10% salary: (10/1/01-9/30/05; 10/1/06-9/30/07). Identification of Autism Susceptibility Loci - The AGRE consortium. 5% salary to provide dysmorphology consultation. NIMH (3/15/02-2/28/07; renewal pending). $1,812,646. Dan Geschwind (PI). (CSMC IRB has approved my submission to participate in this contract.) Cat Eye Syndrome Grant from National Organization for Rare Diseases, $30,000, 10/1/05-9/30/07. John Graham (PI) Danbury CT. The Skeletal Dysplasias. NIH/NICHD Grant HD22657-11. Project period: 12/1/01 to 11/30/06; 12/1/06-4/30/12; Department of Health and Human Services, Public Health Service. David L. Rimoin, M.D., Ph D. (PI), John M. Graham, Jr., MD, ScD (CI). Medical Genetics U CLA Intercampus NIH/NIGMS Training Program Grant. GM08243-16". 7/1/026/30/07; 7/1/07-6/30/12; 7/1/12-6/30/17). David L. Rimoin, M.D., Ph D.; Bill Wilcox (PIs), John M. Graham, Jr., M.D., Sc.D., (Member Faculty Executive Committee). BIBLIOGRAPHY PEER-REVIEWRESEARCH PUBLICATIONS 1. Graham J.M. Jr., Schreiber R.A., and Zemp J.W.: Effect of d-amphetamine sulfate on susceptibility to audiogenic seizures in DBA/2J mice. Behavioral Biology, 10:183-190, 1974. 2. Schreiber R.A. and Graham J.M. Jr.: Audiogenic priming in DBA/2J and C57BL/6J mice: Interactions between age, prime-to-test interval and index of seizure. Dev. Psychobiology, 9:57 66, 1976. 3. Wertelecki W., Graham J.M. Jr., and Sergovich F.: Clinical recognition of triploidy. Obstetrics and Gynecology, 47:69-76, 1976. 4. Graham J.M. Jr. and Smith D.W.: Parietal craniotabes in the neonate: Its origin and relevance. Journal of Pediatrics, 95:114-116, 1979. Printed January 28, 2015 - Page 7 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 38 of 130 PAGEID #: 42342 EXHIBIT 1 5. Graham J.M. Jr., de Saxe M., and Smith D.W.: Sagittal craniostenosis: Fetal head constraint as one possible cause. Journal of Pediatrics, 95:747-750, 1979. 6. Graham J.M. Jr., Badura R.J., and Smith D.W.: Coronal craniostenosis: Fetal head constraint as one possible cause. Pediatrics, 65:995-999, 1980. 7. Graham J.M. Jr. and Smith D.W.: Metopic craniostenosis as a consequence of fetal head constraint: Two interesting experiments of nature. Pediatrics, 65:1000-1002, 1980. 8. Graham J.M. Jr., Miller M.E., Stephan M .J., and Smith D.W.: Limb reduction anomalies and early in-utero limb compression. Journal of Pediatrics, 96:1052-1056, 1980. 9. Miller M.E., Graham J.M. Jr., Higginbottom M .C., and Smith D.W.: Compression-related defects from early amnion rupture: Evidence for mechanical teratogenesis. Journal of Pediatrics, 98:292-297, 1981. 10. Graham J.M. Jr., Hoehn H., Lin, M.S., and Smith D.W.: Diploid-triploid mixoploidy: Clinical and cytogenetic features. Pediatrics, 68:23-28, 1981. 11. Graham J.M. Jr., Higginbottom M .C., and Smith D.W.: Preaxial polydactyly of the foot associated with early amnion rupture: Evidence for mechanical teratogenesis. Journal of Pediatrics, 98:943-945, 1981. 12. Pleet H., Graham J.M. Jr., and Smith D.W.: Central nervous system and facial defects associated with maternal hyperthermia at 4 to 14 weeks gestation. Pediatrics, 67:785-789, 1981. 13. Pauli R.M., Graham J.M. Jr., and Barr M.: Agnathia, situs inversus, and associated malformations. Teratology, 23:85-93, 1981. 14. Pagon R.A., Graham J.M. Jr., Zonana J., and Yong S.L.: Coloboma, congenital heart disease and choanal atresia with multiple anomalies: CHARGE Association. Journal of Pediatrics, 99:223 227, 1981. 15. Graham J.M. Jr., Stephens T.D., Siebert J.R., and Smith D.W.: Determinants in the morphogenesis of muscle tendon insertions. Journal of Pediatrics, 101:825-831, 1982. 16. Stephens T.D., Siebert J.R., Graham J.M. Jr., and Beckwith J.B.: Parasitic conjoined twins, two cases, and their relation to limb morphogenesis. Teratology, 26:115-121, 1982. 17. Hersh J.H., Graham J.M. Jr., Destrempes B.S., and Greenstein R.M. Teschler-Nicola Killian syndrome: A case report. Journal of Clinical Dysmorphology, 1:20-24, 1983. 18. Graham J.M. Jr., Marin-Padilla M., and Hoefnagel D.: Jejunal atresia associated with cafergot injestion during pregnancy. Clinical Pediatrics, 22:226-228, 1983. 19. Graham J.M. Jr., Stephens T.D., Shepard T.H.: Nuchal cystic hygroma in a fetus with presumed Roberts syndrome. American Journal of Medical Genetics, 15:163-167, 1983. Printed January 28, 2015 - Page 8 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 39 of 130 PAGEID #: 42343 EXHIBIT 1 20. Jung J.H., Graham J.M. Jr., Schultz N., and Smith D.W.: Congenital hydranencephaly/porencephaly due to vascular disruption in monozygotic twins. Pediatrics, 73:467-469, 1984. 21. Graham J.M. Jr., Crow H.C., Rawsley E.F., Simmons G.M., and Hoefnagel D.: Enhanced visualization of soft tissues in the study of aborted fetuses through the use of xeroradiography. Teratology, 30:11-24, 1984. 22. Walzer S., Bashir A.S., Graham J.M. Jr., and Silbert A.R.: Communication disorders, learning disorders, learning difficulties and temperamental style in X X Y boys. Journal of Developmental and Behavioral Pediatrics, 5(3):147-149, 1984. 23. Graham J.M. Jr. and Ferm V.H.: Heat and alcohol induced neural tube defects: Interactions with folate in a golden hamster model. Pediatric Research, 19:247-251, 1985. 24. Smith D.W., Marokus R., Graham J.M. Jr.: Tentative evidence of Y-linked statural gene(s) from growth in the testicular feminization syndrome. Clinical Pediatrics 24:189-192, 1985. 25. Siebert J.R., Graham J.M. Jr., and MacDonald C.: Pathologic features of the CHARGE Association: Support for involvement of the neural crest. Teratology 31:331-336, 1985. 26. Graham J.M. Jr., Brown F.E., Saunders R.L., Hinkle A .J., Frank J.E., Harris M.S., Klein R.Z. Bifid epiglottis, hand anomalies and congenital hypopituitarism, Lancet 2:443, 1985. 27. Park J.P., Graham J.M. Jr., Wurster-Hill D.H.: Familial t(4;21) (q2.4;q2.2) leading to an unbalanced offspring with the Down syndrome. American Journal of Medical Genetics, 25:399 402, 1986. 28. Wertelecki W., Breg U.R., Graham J.M. Jr., Iinuma K., Puck S.M., Sergovich F.R.: Trisomy 22 mosaicism syndrome and Ullrich-Turner stigmata. American Journal of Medical Genetics 23:739-749, 1986. 29. Graham J.M. Jr., Brown F.E., Struckmeyer C.L., and Hallowell C.: Dominantly inherited unilateral terminal transverse defects of the hand (adactylia) in twin sisters and one daughter, Pediatrics 78:103-106, 1986. 30. Graham J.M. Jr., Saunders R., Fratkin J., Spiegel P., Harris M., and Klein R.Z.: A cluster of Pallister-Hall syndrome cases (congenital hypothalamic hamartoblastoma syndrome), American Journal of Medical Genetics, Supplement 2, The Developmental Field Concept, Part 2:53-63, 1986. 31. Brown F.E., Cohen L.B., Addante R.R., and Graham J.M. Jr.: Correction of congenital auricular deformities by splinting in the neonatal period. Pediatrics, 78:406-411, 1986. 32. Disteche C.M., Casanova M., Saal H., Friedman C., Sybert V., Graham J.M. Jr., Thuline H., Page D.C., and Fellous M.: Small deletions of the short arm of the Y chromosome in 46,XY females, Proceedings of the National Academy of Sciences, 83:7841-7844, 1986. Printed January 28, 2015 - Page 9 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 40 of 130 PAGEID #: 42344 EXHIBIT 1 33. Graham J.M. Jr., Brown F.E., and Hall B.D.: Thumb polydactyly as part of the range of genetic expression for thenar hypoplasia. Clinical Pediatrics, 26:11-17, 1987. 34. Graham J.M. Jr., Boyle U., Troxell J., Cullity G.J., Sprague P., and Beckwith J.B.: Cystic hamartomata of the lung and kidney: A spectrum of developmental abnormalities, American Journal of Medical Genetics, 27:45-59, 1987. 35. Morse R.P., Rawsley B.E., Crow H.C., Marin-Padilla M., and Graham J.M. Jr.: Bilateral renal agenesis in three consecutive siblings, Prenatal Diagnosis, 7:573-579, 1987. 36. Morse R.P., Rawsley B.E., Sargent S.K., and Graham J.M. Jr.: Prenatal diagnosis of a new syndrome: holoprosencephaly with hypokinesia, Prenatal Diagnosis, 7:631-638, 1987. 37. Park J.P., Wurster-Hill D.H., Graham J.M. Jr., Andrews P.A., and Cooley C.: Free partial trisomy 21 without the Down Syndrome. Clinical Genetics, 32:342-348, 1987. 38. Park J.P., Wurster-Hill D.H., Berg S.Z., and Graham J.M. Jr.: A denovo interstitial deletion of chromosome 6 (q22.2 q23.1), Clinical Genetics, 33:65-68, 1988. 39. Park J.P., Graham J.M. Jr., Andrews P.A., and Wurster-Hill D.H.: Ring chromosome 12. American Journal of Medical Genetics, 29:437-440, 1988. 40. Graham J.M. Jr., Hanson J.W., Darby B.L., Barr H.M., and Streissguth A.P.: Independent dysmorphology evaluations at birth and four years of age for children exposed to variable amounts of alcohol in utero, Pediatrics, 81:772-778, 1988. 41. Graham J.M. Jr., Bashir A.S., Stark R.E., Silbert A., Walzer S.: Oral and written language abilities of XXYboys: Implications for anticipatory guidance. Pediatrics, 81:795-806, 1988. 42. Moeschler J.B., Charman C.E., Berg S.Z., and Graham J.M. Jr.: Rett syndrome: Natural history and management. Pediatrics, 82:1-10, 1988. 43. Knoll J.H.M., Nicholls R.D., Magenis R.E., Graham J.M. Jr., Lalande M., Latt S.A.: Angelman and Prader-Willi syndromes share a common chromosome 15 deletion but differ in parental origin of the deletion. American Journal of Medical Genetics, 32:285-290, 1989. 44. Thomas I.T., Frias J.L., Cantu E.S., Lafer C.Z., Flannery D.B., and Graham J.M. Jr.: The association of pigmentary anomalies with chromosomal and genetic mosaicism and chimerism. American Journal of Human Genetics, 45:193-205, 1989. 45. Moeschler J.B., Pober B., Holmes L.B., and Graham J.M. Jr.: Acrocallosal syndrome: New findings. American Journal of Medical Genetics, 32:306-310, 1989. 46. Tantravahi U., Nicholls R.D., Shroh H., Ringer S., Neve R.L., Kaplan L., Wharton R., Wurster Hill D., Graham J.M. Jr., Cantu E., Frias J., Kousseff B., and Latt S.: Quantitative calibration and use of DNA probes for investigating chromosomal abnormalities in the Prader-Willi syndrome. American Journal of Medical Genetics, 33:78-87, 1989. Printed January 28, 2015 - Page 10 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 41 of 130 PAGEID #: 42345 EXHIBIT 1 47. Nicholls R.D., Knoll J.H., Glatt K., Hersh J., Brewster T., Graham J.M. Jr., Wurster-Hill D., Wharton R., Latt S.: RFLPs within proximal 15q and their use in molecular cytogenetics and the Prader-Willi syndrome. American Journal of Medical Genetics, 33:66-77, 1989. 48. Graham J.M. Jr., Rawnsley E.F., Wurster-Hill D.H., Park J.P., Marin-Padilla M., Crow H.C.: Triploidy: pregnancy complications and clinical findings in seven cases. Prenatal Diagnosis, 9:409-419, 1989. 49. Iafolla A.K., Fratkin J.D., Spiegel P.K., Cohen M.M., and Graham J.M. Jr.: Case report and delineation of the congenital hypothalamic hamartoblastoma syndrome (Pallister-Hall Syndrome). American Journal of Medical Genetics, 33(4):489-499, 1989. 50. Starman B.J., Eyre D., Charbonneau H., Harrylock M., Weis M.A., Weiss L., Graham J.M. Jr., and Byers P.H.: Osteogenesis imperfecta: the position of substitution for glycine by cysteine in the triple helical domain of the pro alphal(I) chains of type I collagen determines the clinical phenotype. J. of Clinical Investigation, 84:1206-1214, 1989. 51. Stern H.J., Graham J.M. Jr., Lachman R.S., Horton W.A., Bernini P.M., Bodurtha J., Bocian M, Ives E., Spiegel P.K., and Rimoin D.L.: Atelosteogenesis type III: a distinct skeletal dysplasia with features overlapping atelosteogenesis and otopalato-digital syndrome type II. American Journal of Medical Genetics, 36(2): 183-195, 1990. 52. Pulst, S.M., Graham, J.M ., Jr., Fain, P., Barker, D., Pribyl, T., and Korenberg, J.R.: The achondroplasia gene is not linked to the locus for neurofibromatosis 1 on chromosome 17. Human Genetics, 85:12-14, 1990. 53. Edwards M.J. and Graham J.M ., Jr.: Studies of type 1 collagen in osteogenesis imperfecta. Journal of Pediatrics, 117:67-72, 1990. 54. Lin, A.E., Morter, G., Siebert, J., and Graham, J.M. Jr.: Central nervous system malformations in the CHARGE Association. American Journal of Medical Genetics, 37(3):304-310, 1990. 55. Morse R.P., Rockenmacher S., Pyeritz R., Sanders S., Bieber F., Lin A., MacLeod P, Hall B., Graham J.M. Jr.: Diagnosis and management of infantile Marfan's syndrome. Pediatrics, 86(6)888-895, 1990. 56. Cooley W.C., Graham E.S., Moeschler J.B., and Graham J.M. Jr.: Reactions of mothers and medical professionals to a film of parents of persons with Down syndrome. American Journal of Diseases of Children, 144(10): 1112-1116, 1990. 57. Donnenfeld A.E., Graham J.M. Jr., Packer R.J., Aquino R., Berg S.Z., and Emanuel B.S.: Microphthalmia and chorioretinal lesions in a girl with an Xp22.2-pter deletion and partial 3p trisomy; clinical observations relevant to Aicardi syndrome gene localization. American Journal of Medical Genetics, 37(2):182-186, 1990. Printed January 28, 2015 - Page 11 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 42 of 130 PAGEID #: 42346 EXHIBIT 1 58. Knoll J.H.M., Nicholls R.D., Magenis R.E., Glatt K., Graham J.M. Jr., Kaplan L., and Laland M.: Angelman syndrome: three molecular classes identified with chromosome 15qll-ql3 specific DNA markers. American Journal of Human Genetics, 47:149-155, 1990. 59. Falik-Borenstein T.C., Korenberg J.R., Davos I., Gans S., Goodman B., Schreck R., Graham J.M. Jr.: Congenital gastric teratoma in Wiedemann-Beckwith syndrome. American Journal of Medical Genetics, 38:52-57, 1991. 60. Finkelstein J.E., Doege K., Yamada Y., Pyeritz R.E., Graham J.M. Jr., Moeschler J.B., and Francomano C.A.: Analysis of the chondroitin sulfate proteoglycan core protein (CSPGCP) gene in achondroplasia and pseudoachondroplasia. American Journal of Human Genetics, 48(1):97102, 1991. 61. Shohat M., Herman V., Melmed S., Neufeld N., Schreck R., Pulst S., Graham J.M. Jr., Rimoin D.L., Korenberg J.R.: Deletion of 20p 11.23^-pter With Normal Growth Hormone-Releasing Hormone Genes. American Journal of Medical Genetics, 39(1):56-63, 1991. 62. Cooley W.C., Graham J.M. Jr.: Down syndrome: an update and review for the primary pediatrician. Clinical Pediatrics, 30(4):233-253, 1991. 63. Wagstaff J., Knoll J.H.M., Fleming J., Kirkness E.F., Martin-Gallardo A., Greenberg F., Graham J.M. Jr., Menninger J., Ward D., Venter J.C., Lalande M.: Localization of the gene encoding the GABAA receptor B3 subunit to the Angelman/Prader-Willi region of human chromosome 15. American Journal of Human Genetics, 49:330-337, 1991. 64. Christian C.L., Lachman R.S., Aylsworth A.S., Fujimoto A., Gorlin R.J., Lipson M.H., Graham J.M. Jr.: Radiological findings in Hallermann-Streiff syndrome: report of five cases and a review of the literature. American Journal of Medical Genetics, 41(4):508-514, 1991. 65. Lachman R.S., Tiller G.E., Graham J.M. Jr., Rimoin D.L.: Collagen, genes and the skeletal dysplasias on the edge of a new era: a review and update. European Journal of Radiology, 14:1 10, 1992. 66. Fischel-Ghodsian N., Bohlman M .C., Prezant T.R., Graham J.M. Jr., Cederbaum S.D., Edwards M.J.: Deletion in blood mitochondrial DNA in Kearns-Sayre syndrome. Pediatric Research, 31:557-560, 1992. 67. Cantrell M .A., Bogan J.S., Simpson E., Bicknell J.N., Goulmy E., Chandler P., Pagon R.A., Walker D.C., Thuline H.C., Graham J.M. Jr., de la Chapelle A., Page D.C., and Disteche C.M.: Deletion mapping of H-Y antigen to the long-arm of the human Y chromosome. Genomics 13,1255-1260, 1992. 68. Perez-Aytes A., Graham J.M. Jr., Hersh J.H., Hoyme H.E., Aleck K., Carey J.C.: The urethral obstruction sequence and lower limb deficiency: Evidence for the vascular disruption hypothesis, Journal of Pediatrics 123(3):398-405, 1993. Printed January 28, 2015 - Page 12 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 43 of 130 PAGEID #: 42347 EXHIBIT 1 69. Cunniff C., Curry C.J.R., Carey J.C., Graham J.M. Jr., Williams C.A., Stengel-Rutkowski S., Luttgen S., Meinecke P.: Congenital diaphragmatic hernia in the Brachmann-deLange syndrome. American Journal of Medical Genetics 47(7):1018-1021, 1993. 70. Braddock S.R., Lachman R.S., Charman C., Carey J.C., Ireland M., Moeschler, J.B., Cunniff C., and Graham J.M. Jr.: The radiological features in Brachmann-deLange syndrome. American Journal of Medical Genetics 47(7):1006-1013, 1993. 71. Moeschler J.B., Graham J.M. Jr.: Mild Brachmann-de Lange syndrome: phenotypic and developmental characteristics of mildly affected individuals. American Journal of Medical Genetics 47(7):969-976, 1993. 72. Sharony R., Garber A., Viskochil D., Schreck R., Platt L.D., Ward R., Buehler B.A., Graham J.M. Jr.: Preaxial ray reduction defects as part of valproic acid embryopathy. Prenatal Diagnosis, 13:909-919, 1993. 73. Bacino C.A., Platt L.D., Carlson D., Garber A., Pepkowitz S., Lachman R.S., Sharony R., Rimoin D.L., Graham J.M. Jr.: Fetal akinesia/ hypokinesia sequence: Prenatal diagnosis and intra-familial variability. Prenatal Diagnosis, 13:1011-1019, 1993. 74. Braddock S.R., Braddock B.A., Graham JM Jr.: Rett syndrome: an update and review for the primary pediatrician. Clinical Pediatrics, 32:613-626, 1993. 75. Skovby F., Graham J.M. Jr., Sonne-Holm S., Cohen M.M. Jr.: Compromise of the spinal canal in Proteus syndrome. American Journal of Medical Genetics 47:656-659, 1993. 76. Garber A., Carlson D., Schreck R., Fischel-Ghodsian N., Wei-Tong H., Klein J., Oeztas S., Pepkowitz S., Williams J. III, Graham J.M. Jr.: Prenatal diagnosis and dysmorphic findings in mosaic trisomy 16. Prenatal Diagnosis 14:257-266, 1994. 77. Klein J., Graham J.M. Jr., Platt L.D., Schreck R.: Trisomy 8 mosaicism in chorionic villi sampling: case report and counseling issues. Prenatal Diagnosis 14:451-454, 1994. 78. Edwards M .J., Park J., Wurster-Hill D.H., and Graham J.M. Jr.: Mixoploidy in humans: two surviving cases of diploid tetraploid mixoploidy and comparison with diploid triploid mixoploidy. American Journal of Medical Genetics 52:324-330, 1994. 79. Korenberg J.R., Chen X.-N, Schipper R., Sun Z., Gonsky R., Gerwehr S., Carpenter N., Daumer C., Dignan P., Disteche C., Graham J.M. Jr., Hudgins L., McGillivray B., Miyazaki K., Ogasawara N., Park J.P., Pagon R., Peuschell S., Sack G., Say B., Schuffenhauer S., Soukup S., and Yamanaka T.: Down syndrome phenotypes: the consequences of chromosomal imbalance. Proceedings of National Academy of Sciences, 91:4997-5001, 1994. 80. Bacino C.A., Schreck R., Fischel-Ghodsian N., Pepkowitz S., Prezant T.R., Graham J.M. Jr.: Clinical and molecular studies in full trisomy 22: Further delineation of the phenotype and review of the literature. American Journal of Medical Genetics, 56:359-365, 1995. Printed January 28, 2015 - Page 13 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 44 of 130 PAGEID #: 42348 EXHIBIT 1 81. Weng E.Y., Moeschler J.B., and Graham J.M. Jr.: Longitudinal observations of 15 children with Beckwith-Wiedemann syndrome. American Journal of Medical Genetics, 56:366-373, 1995. 82. Weng E.Y., Mortier G.R., Graham J.M. Jr.: Beckwith-Wiedemann syndrome: An update and review for the primary pediatrician. Clinical Pediatrics, 34:317-326, 1995. 83. Penny L.A., Dell'Aquila M., Jones M .C., Bergoffen J., Cunniff C., Fryns J.P., Grace E., Graham J.M. Jr., Kousseff B., Mattina T., Syme J., Voullaire L., Zelante L., Zenger-Hain J., Jones O.W., and Evans G.A.: Clinical and molecular characterization of patients with distal 11q deletions. American Journal of Human Genetics, 56:676-683, 1995. 84. Bhatt S., Schreck R., Graham J.M. Jr., Korenberg J.R., Hurvitz C.H., Fischel-Ghodsian N.: Transient leukemia with trisomy 21: description of a case and review of the literature. American Journal of Medical Genetics, 58:310-314, 1995. 85. Meyers G.A., Day D., Goldberg R., Daentl D., Przylepa A., Abrams L.J., Graham J.M. Jr., Feingold M., Moeschler J.B., Rawnsley E., Scott A.F., Jabs E.W.: FGFR 2 Exon Illa and Illx mutations in Crouzon, Jackson-Weiss, and Pfeiffer syndromes: Evidence for missense changes, insertions, and a deletion due to alternative RNA splicing. American Journal of Human Genetics 58:491-498, 1996. 86. Ming J.E., Stiehm E.R., Graham J.M. Jr.: Immunodeficiency as a component of recognizable syndromes. American Journal of Medical Genetics, 66:378-398, 1996. 87. Biesecker L.B., Graham J.M. Jr.: Syndrome of the month: Pallister-Hall syndrome. Journal of Medical Genetics, 33:585-589, 1996. 88. Ruder R.O. and Graham J.M. Jr.: Evaluation and treatment of the deformed and malformed auricle. Clinical Pediatrics, 35:461-465, 1996. 89. Goldberg, Y ., Dibbern K., Klein J., Riccardi V.M ., Graham J.M. Jr.: Neurofibromatosis Type 1 An update and review for the primary pediatrician. Clinical Pediatrics, 35:545-561, 1996. 90. Biesecker L.G., Abbott M., Allen J., Clericuzio C., Feuillan P., Graham J.M. Jr., Hall J., Kang S. , Haskins-Olney A., Lefton D., Neri G., Peters K., Verloes A.: Report from the workshop on Pallister-Hall syndrome and related phenotypes. American Journal of Medical Genetics, 65:76 81, 1996. 91. Biesecker L.G., Kang S., Schaffer A.A., Abbott M., Kelley R.I., Allen J. C., Clericuzio C., Grebe T. , Olney A., and Graham J.M. Jr.: Exclusion of candidate loci and cholesterol biosynthetic abnormalities in familial Pallister-Hall syndrome. Journal of Medical Genetics, 33:947-951, 1996. 92. Kang S., Graham J.M. Jr., Olney A.H., and Biesecker L.G.: GLI3 frameshift mutations cause autosomal dominant Pallister-Hall syndrome. Nature Genetics, 15:266-268, 1997. 93. Thomas J.A., Graham J.M. Jr.: Chromosome 22q11 deletion syndrome: An update and review for the primary pediatrician. Clinical Pediatrics, 36:253-266, 1997. Printed January 28, 2015 - Page 14 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 45 of 130 PAGEID #: 42349 EXHIBIT 1 94. Krantz I., Rand E.B., Genin A., Hunt P., Jones M., Louis A.A., Graham J.M. Jr., Piccoli D.A., Spinner N.B.: Deletions of 20p12 in Alagille syndrome: Frequency and molecular characterization. American Journal of Medical Genetics, 70:80-86, 1997. 95. Dibbern K., Rabinowitz Y .S., Shorr N., and Graham J.M. Jr.: Surgical correction of incomplete cryptophthalmos in Fraser syndrome. American Journal of Ophthalmology, 124:107-109, 1997. 96. Kang S., Allen J., Graham J.M. Jr., Grebe T., Clericuzio C., Patronas N., Ondrey F., Green E., Schaffer A., Abbott M., and Biesecker L.G.: Linkage mapping and phenotypic analysis of autosomal dominant Pallister-Hall syndrome. Journal of Medical Genetics, 34:441-446, 1997. 97. Curry C.J., Stevenson R.E., Cunniff C., Aughton D., Byrne J., Carey J.C., Cassidy S., Cunniff C., Graham J.M. Jr., Jones M .C., KabackM.M., Moeschler, J., Schaefer G.B., Schwartz S., Tarleton J., Opitz J., and the American College of Medical Genetics: Evaluation of mental retardation: recommendations of a consensus conference. American Journal of Medical Genetics, 72:468-477, 1997. 98. Sampson, P.D., Streissguth A.P., Bookstein F.L., Little R.E., Clarren S.K., Dehaene P., Hanson J.W., Graham J.M. Jr.: The incidence of fetal alcohol syndrome and the prevalence of alcoholrelated neurodevelopmental disorder. Teratology, 56:317-325, 1997. 99. Blake K., Davenport S.H., Hall B.D., Hefner M .A., Pagon R., Williams M.S., Lin A.E., Graham J.M. Jr.: CHARGE Association - An update and review for the primary pediatrician. Clinical Pediatrics, 37:159-174, 1998. 100. Alkalay A.L., Graham J.M. Jr., Pomerance J.J.: Evaluation of neonates born with intrauterine growth retardation: Review and practice guidelines. Journal of Perinatology, 18:142-151, 1998. 101. Kerner B., Flaum E., Mathews H., Carlson D.E., Pepkowitz S.H., Hixon H., and Graham J.M. Jr.: Cervical teratoma: Prenatal diagnosis and long-term follow-up. Prenatal Diagnosis, 18:51 59, 1998. 102. Graham J.M. Jr., Braddock S.R., Mortier G.R., Lachman R., Van Dop C., and Jabs E.W.: Syndrome of coronal craniosynostosis with brachydactyly and carpal-tarsal coalition due to Pro250Arg mutation in FGFR3 gene. American Journal of Medical Genetics, 77:322-329, 1998. 103. Graham J.M. Jr., Edwards M .J., and Edwards M.J.: Teratogen Update: Gestational effects of maternal hyperthermia due to febrile illnesses and resultant patterns of defects in humans. Teratology, 58:209-221, 1998. 104. Malzac P., Webber H., Moncla A., Graham J. M. Jr., Kukolich M., Williams C., Pagon R., Ramsdell L., Kishino T., and Wagstaff J.: Mutation analysis of UBE3A in Angelman syndrome patients. American Journal of Human Genetics, 62:1353-1360, 1998. 105. Graham J.M. Jr., Tackels D., Dibbern K., Superneau D., Rogers C., Corning K., Schwartz C.E.: FG syndrome: Report of three new families with linkage to Xq12-q21.1. American Journal of Medical Genetics, 80:145-156, 1998. Printed January 28, 2015 - Page 15 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 46 of 130 PAGEID #: 42350 EXHIBIT 1 106. Dibbern K.M., Graham J.M ., Jr., Lachman R.S., Wilcox W.R.: Cumming syndrome: report of two additional cases. Pediatric Radiology 28:798-801, 1998. 107. Fang P., Lev-Lehman E., Tsai T.-F., Matsuura T., Benton C.S., Sutcliffe J.S., Christan S.L., Kubota T., Halley D .J., Meijers-Heijboer H., Langlois S., Graham J.M. Jr., Beuten J., Willems P.J., Ledbetter D.H., Beaudet A.L.: The spectrum of mutations in UBE3A causing Angelman syndrome. Human Molecular Genetics, 8:129-135, 1999. 108. Graham J.M. Jr., Jones K.L., Brent R.L.: Contribution of clinical teratologists and geneticists to the evaluation of the etiology of congenital malformations alleged to be caused by environmental agents: ionizing radiaiation, electromagnetic fields, microwaves, radionuclides and ultrasound. Teratology, 59:307-313, 1999. 109. Laskari A., Smith A.K., Graham J.M. Jr.: Williams-Beuren Syndrome: an update and review for the primary pediatrician. Clinical Pediatrics, 38:189-208, 1999. 110. Biesecker L.G., Happle R., Mulliken J.B., Weksberg R., Graham J.M. Jr., Viljoen D.L., Cohen M.M. Jr.: Proteus syndrome: Diagnostic criteria, differential diagnosis, and patient evaluation. American Journal of Medical Genetics, 84:389-395, 1999. 111. Graham J.M. Jr., Superneau D., Rogers R.C., Corning K., Schwartz C.E., Dykens E.M.: Clinical and behavioral characteristics in FG syndrome. American Journal of Medical Genetics, 85:470 475, 1999. 112. Marsh D. J., Kum J. B., Lunetta K. L., Bennett M. J., Gorlin R. J., Bodurtha J., Ahmed S.F., Bodurtha J., Crowe C., Curtis M.A., Dasouli M., Dunn T., Felt H., Geraghty M. T., Graham J. M. Jr., Hodgson S. V., Hudgins L., Hunter A., Korf B. R., Manchester D., Miesfeldt S., Murday V. A., Nathanson K., Parisi1 M., Pober B., Romano C., Tolmie J. L., Trembath R., Winter R. M., Zakai E., Zori R. T., Weng L.-P., Dahia1 P. L.M., and Eng C.: PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome. Human Molecular Genetics, 8:1461-1472, 1999. 113. Kerner B., Graham J.M. Jr., Golden J.A., Pepkowitz S.H., Dobyns W.B.: Familial lissencephaly with cleft palate and severe cerebellar hypoplasia. American Journal of Medical Genetics, 87:440-445, 1999. 114. Meira L.B., Graham J.M. Jr., Greenberg C.R., Busch D.W., Doughty A.T.B., Ziffer D.W., Coleman D.M., Savre-Train I., Friedberg E.C.: Manitoba aboriginal kindred with original Cerebro-Oculo-Facio-Skeletal syndrome has a mutation in the Cockayne syndrome Group B (CSB) gene. American Journal of Human Genetics, 66:1221-1228, 2000. 115. Naqvi S., Cole T., Graham J.M. Jr.: Cole-Hughes syndrome and associated autistic features. American Journal of Medical Genetics, 94:149-152, 2000. 116. Kayser M., Henderson L.B., Kreutzman J., Schreck R., and Graham J.M ., Jr.: Blaschkolinear skin pigmentary variation associated with trisomy 7 mosaicism. American Journal of Medical Genetics, 95:281-284, 2000. Printed January 28, 2015 - Page 16 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 47 of 130 PAGEID #: 42351 EXHIBIT 1 117. Graham J.M. Jr., Krakow D., Tolo V.T., Smith A.K., Lachman R.S.: Radiographic findings and Gs-alpha bioactivity studies and mutation screening in acrodysostosis indicate a different etiology from pseudohypoparathyroidism. Pediatric Radiology, 31:2-9, 2001. 118. Schweitzer D.N., Graham, J.M. Jr., Lachman R.S., Jabs E.W., Okajima K., Przylepa K.A., Shanske A., Chen K., Neidich J.A., and Wilcox W.R.: Subtle radiographic findings of achondroplasia in patients with Crouzon syndrome with acanthosis nigricans due to an Ala391Glu substitution in FGFR3. American Journal of Medical Genetics, 98:75-91, 2001. 119. Bar-Cohen, Y., Ferry D.A., Graham, J. M., Jr.: Cardiac surgery in an infant with CHARGE association from the Gaza strip. Medicine of the Americas, 2:103-108, 2001. 120. Graham J.M ., Jr., Anyane-Yeboa K., Raams A., Appeldoorn E., Kleijer W .J., Garritsen V.H., Busch D., Edersheim T.G., and Jaspers N.G.J.: Cerebro-Oculo-Facio-Skeletal syndrome with a nucleotide excision-repair defect and a mutated XPD gene, with prenatal diagnosis in a triplet pregnancy. American Journal of Human Genetics, 69:291-300, 2001. 121. Wang R., Earl D.L., Ruder, R.O., Graham, J.M. Jr.: Syndromic ear anomalies and renal ultrasounds. Pediatrics, 108:e32, http://pediatrics.aappublication.org/content/108/2/e32.full.html, 2001. 122. Visootsak, J., Aylestock, M., Graham, J.M ., Jr.: Klinefelter syndrome and its variants: an update and review for the primary pediatrician. Clinical Pediatrics, 40:639-691, 2001. 123. Graham J.M ., Jr.: Editorial Comment: A recognizable syndrome within CHARGE association: Hall-Hittner syndrome. American Journal of Medical Genetics, 99:120-123, 2001. 124. Rosenberg M .J., Killoran C., Dziadzio L., Chang S., Stone D.L., Meck J., Aughton D., Bird L.M., Bodurtha J., Cassidy S.B., Graham, J.M ., Jr., Grix A., Guttmacher A.E., Hudgins L., Kozma C., Michaelis R., Pauli R., Peters K.F., Rosenbaum K,N., Tifft C.J., Wargowski D., Williams M.S., and Biesecker, L.B.: Scanning for telomeric deletions and duplications and uniparental disomy using genetic markers in 120 children with malformations. Human Genetics, 109:311-318, 2001. 125. Villard L., Nguyen K., Cardoso C., Martin C.L., Weiss A.M., Silfry-Platt M., Grix A.W., Graham, Jr., J.M ., Winter R.M., Leventer R.J., and Dobyns W.B.: A locus for bilateral perisylvian polymicrogyria maps to Xq28. American Journal of Human Genetics, 70:1003-1008, 2002. 126. Ming, J.E., Stiehm, J.R., Graham, Jr. J.M.: Genetic syndromes associated with immunodeficiency. Immunol Allergy Clin N Amer, 22:261-280, 2002. 127. Adams J., Bittner P., Buttar H.S., Chambers C.D., Collins T.F.X., Daston G.P., Filkins K., Flynn T.J., Graham, Jr., J.M ., Jones K.L., Kimmel C., Lammer E., Librizzi R., Mitala J., Polifka J.E.: Statement of the Public Affairs Committee of the Teratology Society on the Fetal Alcohol Syndrome. Teratology 66:344-347, 2002. Printed January 28, 2015 - Page 17 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 48 of 130 PAGEID #: 42352 EXHIBIT 1 128. Elliott, A.M., Graham, J.M ., Jr., Curry, C.J.R., Pal, T., Rimoin, D.L., Lachman, R.S.: The spectrum of dolichospondylic dysplasia - two new patients with distinctive findings. American Journal of Medical Genetics113:351-361, 2002. 129. Wang, R. Martinez-Frias M.L., Graham, Jr. J.M.: Infants of diabetic mothers are at increased risk for the oculo-auriculo-vertebral sequence: a case-based and case-control approach. Journal of Pediatrics, 141:611-617, 2002. 130. Everman D.B., Bartels C.F., Yang Y., Yanamandra N., Goodman F.R., Mendoza-Londono J.R., Savarirayan R., White S.M., Graham, Jr. J.M ., Gale R.P., Svarch E., Newman W .G., Kleckers A.R., Francomano C.A., Govindaiah V., Singh L., Morrison S., Thomas J.T., Warman M.L.: The mutational spectrum of Brachydactyly type C. American Journal of Medical Genetics, 112:291 296, 2002. 131. O 'Connor M .J., Shah B., Whaley S., Cronin P., Gunderson B., Graham, Jr., J.M.: Psychiatric illness in a clinical sample of children with prenatal alcohol exposure. The American Journal of Drug and Alcohol Abuse, 28:743-754, 2002. 132. De Mollerat X .J., Everman D.B., Morgan C.T., Clarkson K.B., Rogers R.C., Colby R.S., Aylsworth A.S., Graham J.M ., Jr., Stevenson R.E., Schwartz C.E.: p63 mutations are not a major cause of non-syndromic split hand/foot malformation. Journal of Medical Genetics, 40:55-61, 2003. 133. Savarirayan R., White S. M., Goodman F. R., Graham Jr., J. M., Delatycki, M. B., Lachman, R. S. Rimoin, D. L., Everman, D. B., Warman, M. L.: Broad phenotypic spectrum caused by an identical heterozygous CDMP-1 mutation in three unrelated families. American Journal of Medical Genetics, 117A:136-142, 2003. 134. Schweitzer, D.N., Earl, D.L., Lachman, R.S. Graham, J.M ., Jr.,: Van Den Ende-Gupta syndrome of blepharophimosis, arachnodactyly, and congenital contractures: clinical delineation and recurrence in brothers. American Journal of Medical Genetics, 118A:267-273, 2003. 135. Lalani S.R., Stockton D.W., Bacino C, Molinari L.W., Glass N.L., Fernbach S.D., Towbin J.A., Craigen W .J., Graham Jr., J.M ., Hefner M .A., Lin A.E., McBride K.L., Davenport S.L., Belmont J.W.: Toward a genetic etiology of CHARGE association: I. A systematic scan for submicroscopic deletions. American Journal of Medical Genetics, 118A:260-266, 2003. 136. Schweitzer D.N., Yano S., Earl D.L., Graham J.M ., Jr.: Johnson-McMillin syndrome, a neuroectodermal syndrome with conductive hearing loss and microtia: report of a new case. American Journal of Medical Genetics, 120A:400-405, 2003. 137. Ming J.E., Stiehm E.R., Graham, Jr. J.M.: Genetic syndromes associated with immune abnormalities. Critical Reviews in Clinical Laboratory Sciences, 40(5): 1-56, 2003. 138. Graham, J.M. Jr., Wheeler P., Tackels-Horne D., Lin A.E., Hall B.D., May M., Short K.M., Schwartz C.E., Cox T.C.: A new X-linked syndrome with agenesis of the corpus callosum, mental retardation, coloboma, micrognathia, and a mutation in the Alpha 4 gene at Xq13. American Journal of Medical Genetics, 123A:37-44, 2003. Printed January 28, 2015 - Page 18 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 49 of 130 PAGEID #: 42353 EXHIBIT 1 139. Simpson J.L., de la Cruz F., Swerdloff R., Samango-Sprouse C., Skakkeback N., Graham, Jr., J.M ., Hassold T., Aylstock M., Meyer-Bahlburg H.F.L., Willard H.F., Hall J.G ., Salameh W., Boone, K., Staessen C., Geschwind D., Giedde J., Dobs A.S., Rogol A., Brinton B., Paulsen C.A.: Klinefelter syndrome: expanding the phenotype and identifying new research directions. Genetics in Medicine, 5:460-468, 2003. 140. Doyle T.F., Bellugi U., Korenberg J.R., Graham, Jr., J.M.: "Everybody in the world is my friend" hypersociability in young children with Williams syndrome. American Journal of Medical Genetics, 124A: 263-273, 2004. 141. Gleeson J.G ., Keeler L.C., Parisi M.A., Marsh, S.E., Chance, P.F., Glass I.A., Graham J.M ., Jr., Maria B.L., Barkovitch A .J., Dobyns W.B.: The molar tooth malformation of the midbrainhindbrain junction: occurrence in multiple distinct syndromes. American Journal of Medical Genetics, 125A: 125-134, 2004. 142. Havens J.M ., Visootsak J., Phelan M .C., Graham, Jr., J.M.: 22q13 deletion syndrome: an update and review for the primary pediatrician. Clinical Pediatrics, 43:43-54, 2004. 143. Krakow D, Robertson SP, King LM, Morgan T, Sebald ET, Bertolotto C, Wachsmann-Hogiu S, Acuna D, Shapiro SS, Takafuta T, Aftimos S, Kim CA, Firth H, Steiner CE, Cormier-Daire V, Superti-Furga A, Bonafe L, Graham JM Jr., Grix A, Bacino CA, Allanson J, Bialer MG, Lachman RS, Rimoin DL, Cohn DH. Mutations in the gene encoding filamin B disrupt vertebral segmentation, joint formation and skeletogenesis. Nature Genetics, 36(4): 405-410, 2004. 144. Graham, J.M ., Jr., Hennekam, R., Dobyns W.B., Roeder E., Busch D.: MICRO syndrome: an entity distinct from COFS syndrome. American Journal of Medical Genetics, 128A(3):235-245 2004. 145. Visootsak J., Rosner B., Dykens E., Schwartz C., Hahn K., White S., Szeftel R., Graham J.M ., Jr.: Clinical and behavioral features of Borjeson-Forssman-Lehmann Syndrome patients with mutations in PHF6. Journal of Pediatrics, 145: 819-825, 2004. 146. Graham, J.M ., Jr., Rosner B., Dykens, E., Visootsak J.: Behavioral features of CHARGE syndrome (Hall-Hittner syndrome): comparison with Down syndrome, Prader-Willi syndrome and Williams syndrome. American Journal of Medical Genetics, 133A: 240-247, 2005. 147. Issekutz K.A., Graham J.M ., Jr., Prasad C., Smith I.M., Blake K.D.: An epidemiological analysis of CHARGE syndrome: preliminary results from a Canadian study. American Journal of Medical Genetics, 133A: 309-317, 2005. 148. Searle L.C., Graham J.M ., Jr., Prasad C., Blake K.D.: CHARGE syndrome from birth to adulthood: an individual reported on from 0 to 33 years. American Journal of Medical Genetics, 133A: 344-349, 2005. 149. Graham J.M ., Jr., Kreutzman J., Earl D., Halberg A., Samayoa C., Guo X.: Deformational brachycephaly in supine-sleeping infants. Journal of Pediatrics, 146:258-262, 2005. Printed January 28, 2015 - Page 19 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 50 of 130 PAGEID #: 42354 EXHIBIT 1 150. Graham J.M ., Jr., Gomez M., Halberg A., Earl D., Kreutzman J., Cui J., Guo X.: Management of deformational plagiocephaly: repositioning versus orthotic therapy. Journal of Pediatrics, 146:258-262, 2005. 151. Wang R., Visootsak J., Danielpour, M., Graham J.M. Jr.: Midline defects in FG syndrome: Does tethered spinal cord contribute to the phenotype? Journal of Pediatrics, 146:537-541, 2005. 152. Visootsak, J., Warren, S.T., Anido, A., Graham, Jr., J.M.: Fragile X syndrome: an update and review for the primary pediatrician. Clinical Pediatrics, 44:371-382, 2005. 153. Aligianis I.A., Johnson C.A., Gissen P., Chen D., Hampshire D., Hofmann K., Maina E., Morgan N.V., Tee L., Morton J., Ainsworth J.R., Horn D., Rosser E., Cole T., Stolte-Dijktra I., Fieggen K., Clayton Smith J., Megarbane A., Shields J., Newbury-Ecob R., Dobyns W.B., Graham J.M ., Jr., Kjaer K.W., Warburg M., Bond J., Trembath R., Harris L.W., Takai Y ., Mundlos S., Tannahill D., Woods C.G., Maher E.A.: Mutations in Rab3 GTPase activating protein (RAB3GAP) catalytic subunit cause Microphthalmia, Cataract, Microcephaly and Micropenis (Warburg MICRO syndrome). Nature Genetics, 37:221-224, 2005. 154. Johnston J.J., Olivos-Glander I., Killoran C., Elson E., Turner J., Peters K., Abbott M.H., Aughton D.J., Aylsworth A.S., Bamshed M .J., Booth, C., Curry C.J., David A., Dinulos M.B., Flannery D.B., Fox M.A., Graham, Jr., J.M ., et al.: Molecular and clinical analyses of Greig cephalopolysyndactyly and Pallister Hall syndromes: Robust phenotype prediction from the type and position of GLI3 mutations. American Journal of Human Genetics, 76:609-622, 2005. 155. Armstrong L, Moneim AAE, Aleck, K, Aughton DJ, Baumann C, Braddock SR, GillessenKaesbach G, Graham JM, Jr, et al.: Further delineation of Kabuki syndrome in 48 well-defined new individuals. American Journal of Medical Genetics, 132A:265-272, 2005. 156. White S.M., Graham, Jr. J.M ., Kerr B., Gripp K., Weksburg R., Cytrynbaum C., Reeder J.L., Stewart F.J., Edwards M., Wilson M., Bankier A.: The adult phenotype in Costello syndrome. American Journal of Medical Genetics, 136A:128-135, 2005. 157. Graham, J.M ., Jr.,: Marshall J. Edwards: discoverer of maternal hyperthermia as a human teratogen. Birth Defects Research (Part A), 73:857-864, 2005. 158. Graham, Jr., J.M. Shaw G.M.: Gene/environment interactions in rare diseases that include common birth defects. Birth Defects Research (Part A), 73:865-867, 2005. 159. Lalani, S.R., Safiullah, A.A., Fernbach S.D., Harutyunyan K.G., Thaller, C., Peterson L.E., McPherson J.D., Gibbs R.A., White L.D., Heffner M., Davenport S.L.H., Graham, Jr., J.M ., Bacino C.A., Glass N.L., Towbin J.A., Craigen W .J., Neish S.R., Lin A.E., Belmont J.W.: Spectrum of CHD7 mutations in 110 individuals with CHARGE syndrome and genotypephenotype correlation. American Journal of Human Genetics, 78:303-314, 2006. 160. Graham, J.M ., Jr., Lee J.: Bosma arhinia microphthalmia syndrome. American Journal of Medical Genetics, 140A:189-193, 2006. 161. Graham J.M ., Jr.: Tummy time is important. Clinical Pediatrics, 45:119-221, 2006. Printed January 28, 2015 - Page 20 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 51 of 130 PAGEID #: 42355 EXHIBIT 1 162. Doswell, B,H., Visootsak J., Brady A.N., Graham, Jr., J.M.: Turner syndrome: an update and review for the primary pediatrician. Clinical Pediatrics, 45:301-313, 2006. 163. Graham J.M ., Jr., Kumar A.: Diagnosis and management of extensive vertex birth molding. Clinical Pediatrics, 45:672-678, 2006. 164. WangR., Jones J.R., Chen S., RogersR.C., FriezM .J., Schwartz C.E., Graham Jr., J.M.: A previously unreported mutation in a Currarino syndrome kindred. American Journal of Medical Genetics, 140A: 1923-1930, 2006. 165. Adam, M.P., Schelley S., Gallagher R., Brady A.N., Barr K., Blumberg B., Shieh J.T.C., Graham, Jr., J.M ., Slavotinek A., Martin M., Keppler-Noreuil K., Storm A.L., Hudgins L: Clinical features and management issues in Mowat-Wilson syndrome. American Journal of Medical Genetics, 140A: 2730-2741, 2006 (winner of John Opitz award for best paper, 2006). 166. Conway R, Danielpour M, Graham Jr., J.M.: Surgical management of cerebellar tonsillar herniation in three patients with macrocephaly-cutis marmorata telangiectatica congenita. Journal of Neurosurgery (4 Suppl Pediatrics), 106:296-301, Editorial and Response 292-295, 2007. 167. Risheg H., Graham, Jr., J.M ., Clark R.D., Rodgers R.C., Opitz J.M ., Moeschler J.B., Pfeiffer A.P., May M., Joseph S.M., Jones J.R., Stevenson R.E., Schwartz C.E., Friez M.J.: A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome. Nature Genetics, 39:451-453, 2007, published online March 4, 2007. 168. Chen C, Visootsak J, Dills S, Graham Jr., JM: Prader-Willi Syndrome: An Update and Review for the Primary Pediatrician. Clinical Pediatrics, 46:580-591, 2007. 169. Ballif BC, Hornor SA, Jenkins E, Madan-Khetarpah S, Surti U, Jackson K, Asamoah A, Farnsworth PL, Gordon C. Gowans GC, Conway RL, Graham, Jr. JM, Medne L, Zackai EH, Tamim H. Shaikh TH, Peggy S. Eis PS, Bassem A. Bejjani BA, Shaffer LG: Discovery of a previously unrecognized microdeletion syndrome of 16p11.2-p12.2. Nature Genetics, 39:1071 1073, 2007, published online August 19, 2007. 170. Visootsak J, Rosner B., Dykens E., Tartaglia N., Graham, Jr., J.M.: Behavioral phenotype of sex chromosome aneuploidies: 48,XXYY, 48,XXXY, and 49,XXXXY. American Journal of Medical Genetics, 143A:1198-1203, 2007. 171. Borozdin W, Graham, Jr. JM, Bohm D, Bamshed M J, Spranger S, Burke L, Olney AH, Leipoldt M, Kohlhase J: Multigene deletions on chromosome 20q13.13-q13.2 including SALL4 result in an extended phenotype of Okihiro syndrome plus developmental delay. Human Mutation, 28:830, published online August 2007. 172. Vatanavicharn N., Graham Jr., J.M ., Curry C.J., Pepkowitz S., Lachman R.S., Rimoin D.L., Wilcox, W.R.: Diaphanospondylodysostosis: six new cases and exclusion of the candidate genes, Pax1 andMeoxl. American Journal of Medical Genetics, 143A:2292-2302 2007. Printed January 28, 2015 - Page 21 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 52 of 130 PAGEID #: 42356 EXHIBIT 1 173. Conway R.L., Pressman B., Dobyns B., Danielpouir M., Lee, J., Butler M .G., Zachai E., Close L . , Saitta S.C., Clericuzio C., Milunsky J., Hoyme G., Shieh J., Moeschler J.B., Crandall B., Lauzon J.L., Graham Jr., J.M.: Neuroimaging findings in macrocephaly-capillary malformation syndrome: a longitudinal study of17 patients. American Journal ofMedical Genetics, 143A:2981-3008, 2007. 174. Sanchez-Lara, P.A., Graham, Jr., J.M ., Lee J., Hing A .V., Cunningham M.: The morphogenesis of wormian bones: a study of craniosynostosis and purposeful cranial deformation. American Journal of Medical Genetics, 143A:3243-3251, 2007. 175. Laury A., Sanchez-Lara P.A., Pepkowitz S., Graham, Jr., J.M.: A study of 534 fetal pathology cases from prenatal diagnosis referrals analyzed from 1989 through 2000, American Journal of Medical Genetics, 143A:3107-3120, 2007. 176. Graham, Jr., J.M ., Visootsak, J., Huddleson L., Dykens, E., Clark, R.D., Jones, K.L., Moeschler, J.B., Opitz J.M ., Morford J., Simensen R., Rogers, R.C., Lyons M .J., Schwartz,, C.E., Friez, M . J., Stevenson, R.E.: Behavioral features in 10 patients with FG syndrome (Opitz-Kaveggia syndrome) and the p.R961W mutation in the MED12 gene. American Journal of Medical Genetics, 146A:3011-3017, 2008. 177. Lyons, M .J., Graham, Jr., J.M ., Neri, G., Hunter, A.G.D., Clark, R.D., Rogers, R.C., Moscarda, M., Simensen, R., Dodd, J., Robertson S., Dupont, B.R., Friez, M .J., Schwartz C.E., Stevenson, R.E.: Clinical experience in the evaluation of 30 patients with a prior diagnosis of FG syndrome. Journal of Medical Genetics, 46:9-13, 2009. 178. Adam, M.P., Hudgins L., Carey, J.C ., Hall, B.D., Coleman K., Gripp K.W., Perez-Aytes A., Graham, Jr., J.M.: Preaxial hallucal polydactyly as a marker for diabetic embryopathy. Birth Defects Research Part A; Clinical and Molecular Teratology, 85:13-19, 2009. 179. Hall, B.D., Graham, Jr., J.M ., Cassidy, S.B., Opitz, J.M.: Elements of morphology: standard terminology for the periorbital region. American Journal of Medical Genetics, 149A:29-39, 2009. 180. Dai, L., Bellugi, U., Chen, X.-N., Pulst-Korenberg, A.M., Jarvinen-Pasley, A., Tirosh-Wagner, T., Eis P.S., Graham, Jr., J.M ., Mills, D., Searcy, Y ., Korenberg J.R.: Is it Williams syndrome? GTF2IRD1 implicated in visual-spatial construction and GTF2I in sociability revealed by high resolution arrays. American Journal of Medical Genetics, 149A:302-314, 2009. 181. Graham J.M ., Jr., Kramer, N., Bejjani, B., Thiel, C.T., Carta, C., Neri, G, Tartaglia M., Zenker, M.: Genomic duplication of PTPN11 is an uncommon cause of Noonan syndrome. American Journal of Medical Genetics, 149A:2122-2128, 2009. 182. Pariani M .J., Spencer A., Graham, Jr., J.M ., Rimoin D.L.: A 785 kb deletion of 3p14.1p13, including the FOXP1 gene, associated with speech delay, contractures, hypertonia and blepharophimosis. European Journal of Medical Genetics, 52:123-127, 2009. Printed January 28, 2015 - Page 22 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 53 of 130 PAGEID #: 42357 EXHIBIT 1 183. Clark, R.D. Graham, Jr., J.M ., Friez M .J., Hoo, J.J., Jones, K.L., McKeown C., Moeschler, J.B., Raymond F.L., Rogers, R.C., Schwartz, C.E., Battaglia A., Lyons M .J., Stevenson, R.E.: The clinical phenotype of FG (Opitz-Kaveggia): an algorithm for diagnostic testing. Genetics in Medicine, 11:769-775, 2009. 184. Visootsak J. and Graham, Jr. J.M.: Social function in multiple X and Y chromosome disorders: X X Y , X Y Y , X X Y Y , X X X Y . Developmental Disabilities Research Reviews, 15:328-332, 2009. 185. El-Gharbawy A.H., Peeden J.N., Lachman R.S., Graham, Jr., J.M ., Moore S.R., Rimoin D.L.: Severe cleidocranial dysplasia and hypophosphatasia in a child with microdeletion of the Cterminal region of RUNX2. American journal of Medical Genetics, 152A:169-174, 2010. 186. Sanchez-Lara P.A., Carmichael S.L., Graham, Jr., J.M ., Lammer E.J., Shaw G. M., Ma C., Rasmussen S.A., National Birth Defects Prevention Study: Fetal constraint as a potential risk factor for craniosynostosis. American Journal of Medical Genetics, 152A:394-400, 2010. 187. Graham J.M ., Jr., Spencer A.H., Grinberg I., Niesen C., Platt L.D., Maya M., Namavar Y ., Baas F. , Dobyns W.: Molecular and neuroimaging findings in pontocerebellar hypoplasia type 2 (PCH2): Is prenatal diagnosis possible? American Journal of Medical Genetics, 152A:22682276, 2010. 188. Graham Jr., J.M ., Clark R.D., Moeschler J.B., Rogers R.C.: Behavioral features in young adults with FG syndrome (Opitz-Kaveggia syndrome). American Journal of Medical Genetics, 154C:477-485, 2010. 189. Johnston JJ, Sapp JC, Turner JT, Amor D, Artimos S, Aleck KA, Bocian J, Bodurtha JN, Cox G, Curry C, Day R, Donnai D, Field M, Fujiwara I, Gabbet M, Gal M, Graham Jr. JM, Hedera P, Hennekam RCM, Hirsch J., Hopkin R., Jabs EW, Kayserili H, Kidd AM J, Kimonis V, Lin AE, Lynch SA, Maisenbacher M, Mansour S, McGaughran J, Mehta L, Murphy H, Ragada M, Robin NH, Rope AF, Rosenbaum KN, Schaefer GB, Shealy A, Smith W, Soller M, Sommer AM, Stalker HJ, Steiner B, Stefan M, Tilstra D, Tomkins S., Trapane P, Tsai A, Van Allen MI, Vasudevan PC, Zabel B, Zunich J, Black GC, Biesecker LB: Molecular analysis expands the spectrum of phenotypes associated with GLI3 mutations. Human Mutation, 10:1142-1154, 2010. 190. Namavar Y, Barth PG, Kasher PR, Brockman K, Bernerr G, Writzl K, Ventura K, Neufeld Kaiser W, Ferrierro DM, Basel-Vanagaite L, Eggens V, Krageloh-Mann I, De Meirleir L, King M, Graham, Jr. JM, von Moers A, Knoers N, Sztriha L, Korinthenberg R, Dobyns WB, Baas F, Poll-The BT: Clinical, neuroradiological and genetic findings in pontocerebellar hypoplasia. Brain, 134:143-156, 2011. 191. Busse T., Graham, Jr., J.M ., Feldman G., Perin J., Catherwood A., Knowlton R., Rappaport E.F., Emanuel B., Driscol D.A., Saitta S.C.: Hign resolution genomic arrays identify CNVs that phenocopy the chromosome 22q11.2 deletion syndrome, Human Mutation, 32:91-97, 2011. Printed January 28, 2015 - Page 23 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 54 of 130 PAGEID #: 42358 EXHIBIT 1 192. Bern D., Yoshimura S-I, Nunes-Bastos R., Bond F.F., Kurlan M .A., Rahman F., Handley Hadzhiev Y., Masood I., Straatman-Iwanowska A.A., Cullinane A.R., McNeill A., Pasha S.S., Kirby G.A., Foster K., Ahmed Z., Morton J.E., Williams D., Graham, Jr. J.M., Dobyns W.B., Burglen L., Ainsworth J.R., Gissen P., Muller F, Maher E.R., Barr F.A., Aligianis I.A.: Loss-of-function mutations in RAB18 cause Warburg Micro syndrome. American Journal of Human Genetics 88:499-507, 2011. 193. Nemec U., Nemec S.F., Krakow D., Brugger P.C., Malinger G., Graham J.M ., Jr., Rimoin D.L., Prayer D.: The skeleton and musculature on foetal MRI. Insights Imaging, 2:309-318, 2011. 194. Burkardt D.D., Rosenfeld J.A., Helgeson M.L. Angle B., Banks V., Smith W.E., Gripp K.W., Moline J., Moran R.T., Niyazov D.M., Stevens C.A., Zackai E., Lebel R.R., Ashley D.G., Kramer N., Lachman R.S., Graham, J.M. Jr.:Distinctive phenotype in 9 patients with deletion of chromosome 1q24-q25. American Journal of Medical Genetics, 155A:1336-1351, 2011. 195. Nemec S., Kasprian G., Brugger P., Bettelheim D., Amann G., Nemec U., Rotmensch S., Graham, J.M ., Jr, Rimoin D.L, Lachman R., Prayer D.: Abnormalities of the upper extremity on fetal MRI. Ultrasound in Obstetrics and Gynecology, 38:559-567, 2011. 196. Nemec S.F., Ursula U., Weber M., Kasprian G., Brugger P. C., Krestan C. R., Rotmensch S., Rimoin D. L., Graham J. M., Jr, Prayer D.: Male sexual development in utero: testicular descent on prenatal MRI. Ultrasound in Obstetrics and Gynecology, 38:688-694, 2011. 197. Nemec S., Nemec U., Weber M., Rotmensch S., Kasprian G., Brugger P., Krestan C.R., Rimoin D.L, Graham, J.M ., Jr, Prayer D.: Female external female genitalia on fetal MRI. Ultrasound in Obstetrics and Gynecology, 38:695-700, 2011. 198. Nemec S.F., HoftbergerR., NemecU., BettelheimD., BruggerP. C., KasprianG., AmannG., Rotmensch S., Graham J. M. Jr., RimoinD. L., Daniela PrayerD. Fetal akinesia and associated abnormalities on prenatal MRI. Prenatal Diagnosis, 31:484-490, 2011. 199. Nemec S.F., KasprianG., BruggerP. C., BettelheimD., NemecU., Krestan C. R., Rotmensch S., RimoinD. L., Graham J. M. Jr., PrayerD. Abnormalities of the penis in utero - hypospadius on fetal MRI. J Perinatal Med. 39:451-456, 2011. 200. Nemec S. F., Horcher E., Kasprian G., Brugger P.C., Bettelheim D., Amann G., Nemec U., Rotmensch S., Rimoin D.L., Graham J.M ., Jr., Prayer D.: Tumor disease and associated congenital abnormalities on prenatal MRI. European Journal of Radiology, 81:e115-e122, 2012. 201. Nemec S. F., Nemec U., Weber M., Brugger P.C., Bettelheim D., Krestan C. R., RimoinD. L., Graham J. M. Jr., PrayerD.: Penile biometry on prenatal MR imaging. Ultrasound in Obstetrics and Gynecology, 39:330-335, 2012. 202. Nemec S., Nemec U., Bettelheim D., Brugger P.C., Horcher E., Schopf V., Graham J.M. Jr., Rimoin D.L., Prayer D.: Ovarian cysts on prenatal MRI. European Journal of Radiology, 81:1934-1944, 2012. Printed January 28, 2015 - Page 24 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 55 of 130 PAGEID #: 42359 EXHIBIT 1 203. Nemec S.F., Brugger P.C., Nemec U., Bettelheim D., Kasprian G., Amann G., RimoinD.L., Graham J.M. Jr., Prayer D.: Situs anomalies on prenatal MRI. European Journal of Radiology, 81:e495-e501, 2012. 204. Klaassens M., Reinstein E., Hilhorst-Hofstee Y., Schrander J.J.P., Malfait F., Staal H., ten Have L.C., Blaauw J., Roggeveen H.C.J., Krakow D., De Paepe A., van Steensel M.A.M., Pals G., Graham, Jr., J.M ., Schrander-Stumpel C.T.R.M.: Ehlers-Danlos syndrome arthrochalasia type (VIIA-B) - expanding the phenotype: from prenatal life through adulthood. Clinical Genetics, 82:121-130, 2012. 205. Noh G. J., Graham J. M., Jr.: 2q23.1 microdeletion of the MBD5 gene in a female with seizures, developmental delay and distinct dysmorphic features, European Journal of Medical Genetics, 55: 354-357, 2012. 206. Graham J. M., Jr., GLUT1 deficiency syndrome as a cause of encephalopathy that includes cognitive disability, treatment-resistant infantile epilepsy and a complex movement disorder. European Journal of Medical Genetics 55(5):332-334, 2012. 207. Noh G .J., Tavyev Asher Y. J., Graham, J. M., Jr.: Clinical review of genetic epileptic encephalopathies. European Journal of Medical Genetics, 55(5):281-298, 2012. 208. O 'Leary R.E., Shih J.C., Hyland K., Kramer N., Tavyev Asher Y .J., Graham J.M ., Jr.: De novo microdeletion of Xp11.3 exclusively encompassing the monoamine oxidase A and B genes in a male infant with episodic hypotonia: a genomics approach to personalized medicine. European Journal of Medical Genetics, 55(5):349-353, 2012. 209. Nemec S.F., NemecU., Brugger P.C., Bettelheim D., RotmenschS., Graham J. M. Jr., RimoinD. L., Daniela Prayer D.: M R imaging of the fetal musculskeletal system. Prenatal Diagnosis, 32:205-213, 2012. 210. Rimoin L., Graham J.M ., Jr.: Blistering skin disorders in the neonate. Clinical Pediatrics, 51:685 688, 2012. 211. Rimoin L., Graham J.M ., Jr.: Ichthyotic skin disorders in the neonate. Clinical Pediatrics, 51:791-795, 2012. 212. Mirzaa G.M., Conway R.L., Gripp K.W., Lerman-Sagie T., Siegel D.H., deVries L.S., Lev D., Kramer N., Hopkins E., Graham, J.M. Jr., Dobbyns W.B. Megalencephaly-Capillary Malformation (MCAP) and Megalencephaly- Polydactyly- Polymicrogyria-Hydrocephalus (MPPH) syndromes: two closely-related disorders of brain overgrowth and abnormal brain and body morphogenesis. American Journal of Medical Genetics, Part A, 158A: 269-291, 2012 (Winner of 2013 John M. Opitz Young Investigator Award from Wiley-Liss for the best 2012 paper by a fellow in the American Journal of Medical Genetics). 213. Lee H., Graham, Jr., J.M ., Rimoin D.L., Lachman R.S., Krejci P., Nelson S.F., Krakow D., Cohn D.H.: Exome sequencing identifies mutations in PDE4D in acrodysostosis. American Journal of Human Genetics, 90:746-751, 2012. Printed January 28, 2015 - Page 25 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 56 of 130 PAGEID #: 42360 EXHIBIT 1 214. Nemec U., Nemec S.F., Brugger P.C., Bettelheim D., Weber M., Graham J.M. Jr., Rimoin D.L., Prayer D.: Male genital abnormalities in intrauterine growth restriction, Prenatal Diagnosis, 32:4 27-431, 2012. 215. Nemec U., Nemec S.F., Weber M., Brugger P.C., Bettelheim D., Wadhawan I., Kolb A., Graham J.M. Jr., Rimoin D.L., Prayer D.: Clubfeet and associated abnormalities on fetal magnetic resonance imaging. Prenatal Diagnosis, 32:822-828, 2012. 2012. 216. Moh W., Graham Jr. J.M ., Isha Wadhawan I, Sanchez-Lara Pa: Extrinsic factors influencing fetal deformations and intrauterine growth restriction. Journal of Pregnancy, 2012:750485. Epub 2012 Jul 19. 217. Riviere J-B, Mirzaa GM, O 'Roak BJ, Beddaoui M, Alcanrtara D., Conway RJ, St-Onge J, Schwartzentruber, JA, Gripp, KW, Nikkel, SM, Worthylake T, Sullivan CT, Ward TR, Butler HE, Kramer NA, Albrecht B, Armour CM, Armstrong L, Caluferiu O, Cytrynbaum C, Drolet BA, Innes AM, Lauzon JL, Lin AE, Mancini GMS, Meschino WS, Reggin JD, Saggar AK, Lerman-Sagie T, Uyanik G, Weksberg R, Zirin B, Beaulieu CL, FORGE Canada Consortium, Majewski J, Bulman DE, O 'Driscoll M, Shendure J, Graham Jr. JM, Boycott KM, Dobyns WB: De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes, Nature Genetics, 44(8):934-40. 2012. 218. Shah H., Bens S., Caliebe A., Graham Jr. J.M ., Girisha K.M.: Growth retardation, intellectual disability, facial dysmorphism, cataract, thoracic hypoplasia and skeletal abnormalities: a novel phenotype. American Journal of Medical Genetics, Am J Med Genet Part A. 158A: 2941-2945, 2012 219. Reinstein E, Frentz S, Morgan T, Garcia-Minaur S, Leventer RJ, McGillivray G, Pariani1 M, van der Steen Siegel R, A, Pope M, Zurita MB, RHoodldriegru-EezspJiIn, aMsoseraMle,s1ScCo,ttRRo,dTrihgoumespYso,nAErcMas, Robertson T, Coppin B, J, Saggar A, Horton M, Zackai E, Graham, Jr., JM, Rimoin DL and Robertson SP: Vascular and connective tissue anomalies associated with X-linked periventricular heterotopia due to mutations in FLNA. European Journal of Human Genetics, 21:494-502, 2013. 220. McDonell L.M., Mirzaa G.M, Alcantara D., Schwartzentruber J., Carter M., Clericuzio C.L., Graham Jr., J.M ., Rosendahl D., Polster, Acsadi T.G., Townshend, S., Williams, S., Isidor B., Smyser C., Paciokowski A., Willing M., Beaulieu C.L., Marcadier J., Geraghty M.T., Majewski J., Bulman D.E., Dobyns W.B., O 'Driscoll M., Boycott, K.M. on behalf of the FORGE Canada Consortium. Microcephaly-Capillary Malformation Syndrome: A Novel RASopathy Caused by Mutations in the Deubiquitinating Enzyme STAMBP. Nature Genetics 45: 556-562, 2013. 221. Alkalay AL, Graham, Jr. JM, Kotton RH, Forbis SA, Fuscaldo MC, Simmons CF, Klein AH: Very low birth weight infant outcome stratified by gestational age and birth weight. Neonatal Intensive Care 24:18-23, 2013. 222. Russell B., Graham Jr., J.M.: Expanding our knowledge of conditions associated with the ASXL gene family. Genome Medicine, 5:16,2013. Printed January 28, 2015 - Page 26 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 57 of 130 PAGEID #: 42361 EXHIBIT 1 223. Mirzah G., Conway R., Graham Jr., J.M ., Dobyns W.B.: PIK3CA-Related Segmental Overgrowth. In: Pagon RA, Adam MP, Bird TD, et al., editors. GeneReviewsTM [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2013. Available from: http://www.ncbi.nlm.nih.gov/books/NBK153722/ Aug. 15,2013. 224. Graham, Jr. JM, and Schwartz CE: MED12-related disorders. American Journal of Medical Genetics Part A, 161A: 2734-2740, 2013. 225. Santen GWE, Aten E, Vulto-van Silfhout AT, Pottinger C, van Bon BW, Van Minderhout IJ, Snowdowne R, van der Lane CA, Boogaard M, Linssen MM, Vijhuizen L, van der Wielen MJR, Vollebregt MJE, Vollebregt MJ; the Coffin-Siris consortium Breuning MH, Kriek M, van Haeringen A, den Dunnen JT, Hoischen A, Clayton-Smith J, de Vries BB, Hennekam RC, van Belzen MJ, Almureikhi M, Baban A, Barbosa M, Ben-Omran T, Berry K, Bigoni S, Boute O, Brueton L, van der Burgt I, Canham N, Chandler KE, Chrzanowska K, Collins AL, de Toni T, Dean J, den Hollander NS, Flore LA, Fryer A, Gardham A, Graham JM Jr, Harrison V, Horn D, Jongmans MC, Josifova D, Kant SG, Kapoor S, Kingston H, Kini U, Kleefstra T, KrajewskaWalasek M, Kramer N, Maas SM, Maciel P, Mancini GM, Maystadt I, McKee S, Milunsky JM, Nampoothiri S, Newbury-Ecob R, Nikkel SM, Parker MJ, Prez-Jurado LA, Robertson SP, Rooryck C, Shears D, Silengo M, Singh A, Smigiel R, Soares G, Splitt M, Stewart H, Sweeney E, Tassabehji M, Tuysuz B, van Eerde AM, Vincent-Delorme C, Wilson LC, Yesil G: CoffinSiris syndrome and the BAF complex: genetype-phenotype study in 63 patients. Human Mutation 34:1519-1528, 2013. 226. Ezgu F.S., Krejci P., Li S., deSousa C, Graham, Jr. J.M ., Hansmann I., He W., Porpora K., Wand D., Wertelecki W., Schneider A., Wilcox W.R.: Phenotype-genotype correlations in patients with the Marinesco-Sjogren syndrome. Clinical Genetics, 86:74-84, 2014. 227. Burkhardt D.D., Graham, Jr. JM, Short S.S., Frykman P.: Advances in Hirschsprung disease genetics and treatment strategies: an update for the primary care pediatrician. Clinical Pediatrics, 53:71-81.2014. 228. Au PY, Racher HE Graham, Jr. JM, Kramer N., Lowery RB, Parboosingh JS, Innes AM, FORGE Canada Consortium: De novo exon 1 missense mutations of SKI and ShprintzenGoldberg syndrome: two new cases and a clinical review. American Journal of Medical Genetics Part A, 164: 346-352, 2014. 229. Kuo AA, Tritasavit S, Graham Jr., J.M.: Congenital muscular torticollis and positional plagiocephaly. Pediatrics in Review 35:79-87; 2014. 230. GirishaKM, AbdollahpourH, ShahH, Bhavani SLG, Graham JM Jr., Boggula VR, Phadke SR, Kutsche K: A syndrome of facial dysmorphism, cubital pterygium, short distal phalanges, swan neck deformity of fingers and scoliosis, American Journal of Medical Genetics, Patr A, 164:1035-1040, 2014. 231. Babkina N, Graham Jr, JM: New genetic testing in prenatal diagnosis. Seminars in Fetal and Neonatal Medicine, 19: 214- 219, 2014. Printed January 28, 2015 - Page 27 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 58 of 130 PAGEID #: 42362 EXHIBIT 1 232. Keppler-Noreuil KM, Sapp JC, Lindhurst MJ, Parker VER, Blumhorst C, Darling T, Tosi LL, Huson SM, Whitehouse RW, JakkulaE, Grant I, BalasubramanianM, Chandler KE, Fraser JL, Gucev Z, Crow Y J, ManaceLM, Clark RD, Sellars EA, Pena LDM, Krishnamurth V, Shuen A, Braverman N, Cunningham ML, Sutton VR, Tasic V, Graham Jr JM, Geer Jr J, A. Henderson A, Semple RK, Biesecker LG: Clinical delineation and natural history of PI3KCA -related overgrowth spectrum. American Journal of Medical Genetics, Part A 164:1713-33., 2014. 233. Hunter AG, Graham JM, Neri G, Rogers RC, Stevenson RE, Turner G, Friez MJ. The intellectual disabilities evaluation and advice system (IDEAS): Outcome of the first 55 cases. Am J Med Genet Part A 164A: 1102-1117, 2014. 234. Dhamija R, Graham, Jr, JM, Smaoui, N, Erik Thorland E, Kirmani S: Novel de novo SPOCK1 mutation in a proband with developmental delay, microcephaly and agenesis of corpus callosum. European Journal of Medical Genetics 57: 181e-184, 2014. 235. McMillin MJ, Beck AE, Chong JX , Shively KM, Buckingham KJ, Gildersleeve HI, Aracena MI, Aylsworth AS, Bitoun P, Carey J, Clericuzio CL, Crow Y J, Curry CJ, Devriendt K, Everman DB, Fryer A, Gibson K, Giovannuci-Uzielli ML, Graham Jr. JM, Hall JG, Hecht JT, Heidenreich RA, Hurst JA, Irani S, Krapels IPC, Leroy JG, Mowat D, Plant G, Robertson SP, Schorry EK, Stumpel C, Scott RH, SeaverLH, SherrE, Splitt M, Stewart H, Temel S, Weaver DW, Whiteford M, Williams MS, Tabor HK, Smith JD, Shendure J, Nickerson DA, University of Washington Center for Mendelian Genomics, Bamshad MJ: Mutations in PIEZO2 Cause Gordon Syndrome, Marden-Walker Syndrome and Distal Arthrogryposis Type 5. The American Journal of Human Genetics, 94: 734-744, 2014. 236. Shih EM, Graham Jr. JM: Review of genetic and environmental factors leading to hypospadias. European Journal of Medical Genetics, 57: 453-463, 2014. 237. Graham Jr. JM, Hennekam RC: Genetics of common malformations. European Journal of Medical Genetics, 57:353-354, 2014. 238. Castillo A, Kramer N, Schwartz CE, Miles JH, DuPont BR, Rosenfeld JA, Graham Jr, JM: 19q13.32 microdeletion syndrome; three new cases. European Journal of Medical Genetics, 57:654-658, 2014. 239. Babkina N, Deignan JL, Lee H, Sanjar R, Vilain E, Giurgea I, Mowat D, Graham Jr. JM: Early infantile epileptic encephalopathy with a de novo variant in ZEB2 identified by exome sequencing. Submitted to American Journal of Medical Genetics, 2014. 240. Barber JCK, Rosenfeld JA, Graham, Jr. JM, Kramer N., Lachlan K, Bateman MS, Collinson MN, Stadheim BF, Turner CLS, Stevens AK, Delk P, Weaver DD, Gauthier JN, Reimschisell TE, Queshi AM, Dabir TA, Humphries MW, Marble M, Huang T, Beal SJ, Massiah J, Taylor EJ, Wyn S: Inside the 8p23.1 duplication syndrome; nine microduplications of likely or uncertain clinical significance. Submitted to American Journal of Medical Genetics, 2014. 241. Wyszynski D.F., Carmen W .J., Cantor A.B., Graham, Jr., J.M ., Kunz L.H., Slavotinek A.M., Kirby R.S. Seeger J.: Pregnancy and birth outcomes among women with idiopathic thrombocytopenic purpura. In preparation, 2015. Printed January 28, 2015 - Page 28 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 59 of 130 PAGEID #: 42363 EXHIBIT 1 242. Russell B, Johnston JJ, Biesecker LG, Kramer N, Pickart A, Rhead W, Tan W-H, Brownstein CA, Clarkson LK, Dobson A, Rosenberg AZ, Graham JM Jr.: Clinical management of patients with ASXL1 mutations and Bohring-Opitz Syndrome, emphasizing the need for Wilms tumor surveillance. American Journal of Medical Genetics, in revision 2015. 243. Mirzaa G.M., Conway R.L., Kramer N., Graham, Jr. J.M ., Dobyns W.B.: The megalencephalycapillary malformation (MCAP) syndrome without megalencephaly: expanding the spectrum of a unique overgrowth disorder. In preparation for American Journal of Medical Genetics, 2015. 244. Mencias I, Vatanavicharn N, Borozdin W, Kohlhase J, Graham, Jr., J.M.: Wildervanck syndrome: an asymmetrical phenotype with discordant expression in monozygous twins. In preparation, 2014. 245. Reinstein E., Graham, Jr, J.M ., Falk R, Schreck R: Double autosomal/sex chromosome aneuploidy revisited: mechanisms reviewed. In preparation, 2014. 246. Farington-Rock C., Graham, Jr., J.M ., Taylor K.D., Kirilova V., Cohn D., Roberts S.P., Krakow D.: Germline and somatic mosaicism for filamin B mutations in Larsen syndrome. In revision for Journal of Medical Genetics, 2014. 247. Beck A.E., Hudgins L., Carey J.C ., Graham, Jr., J.M ., Grix A.W., Dent K.M., Chen E., AbdulRahman O., Kimonos V., Lazzeroni L.C., Bamshad M., Hoyme H.E., Francke U: Phenotypic analysis of familial oculo-auriculo-vertebral spectrum, In preparation, 2014. INVITED RESEARCH PUBLICATIONS 1. Graham J.M. Jr.: Craniostenosis: A new approach to management. Pediatric Annals, 10:258-264, 1981. 2. Walzer S., Graham J.M. Jr., Bashir A.S. and Silbert A.R.: Preliminary observations on language and learning in X X Y boys. Birth Defects Original Article Series, 18(4): 185-192, 1982. 3. Koskinen-Moffett L.K., Moffett B.C. and Graham J.M. Jr.: Cranial synostosis and intrauterine compression: a developmental study of human sutures, In: Factors and Mechanisms Influencing Bone Growth, New York, AR Liss, Inc., pp. 365-378, 1982 4. Graham J.M. Jr. Alterations in head shape as a consequence of fetal head constraint. Seminars in Perinatology, 7:257-269, 1983. 5. Graham J.M. Jr., Limb anomalies as a consequence of spatially-restricting uterine environments. In: Fallon JF and Caplan AI (Eds.) Limb Development and Regeneration: Part A, New York, AR Liss, Inc., pp. 413-422, 1983. 6. Graham J.M. Jr., Harris M., Frank J.E., Little G.A. and Klein R.Z., Congenital hypothalamic hamartoblastoma syndrome: Natural history and genetic implications., In: Bartsocas CS (Ed.) Endocrine Genetics and Genetics of Growth, New York, AR Liss, Inc., pp 163-174, 1985. Printed January 28, 2015 - Page 29 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 60 of 130 PAGEID #: 42364 EXHIBIT 1 7. Graham J.M. Jr., The effects of alcohol consumption during pregnancy. Prevention of Physical and Mental Defects, Part C: Basic and Medical Science, Education, and Future Strategies, New York, ARLiss, Inc., pp 335-339, 1985. 8. Graham J.M. Jr., The association between limb anomalies and spatially-restricting uterine environments. Prevention of Physical and Mental Defects, Part C: Basic and Medical Science, Education, and Future Strategies, New York, A.R. Liss, Inc., pp. 99-103, 1985. 9. Walzer S., Bashir A.S., Graham J.M. Jr., Silbert A.R., Lange N.T., Denapoli M.F. and Richmond J.B.: The behavioral development of boys with X chromosome aneuploidy: Impact of reactive style on the educational intervention for learning deficits. Birth Defects Original Article Series 22(3):1-21, 1986. 10. Graham J.M. Jr. and Edwards M .J., Teratogenic effects of maternal hyperthermia. In: Proceedings of the 9th Environmental Medicine Symposium: Environmental Factors and Developing Brain, Supplement of Annals of the Research Institute of Environmental Medicine, pp. 365-374, Nagoya University, Japan, 1989. 11. Graham J.M. Jr., Clinical approach to human central nervous system defects. In: Proceedings of the 9th Environmental Medicine Symposium: Environmental Factors and Developing Brain, Supplement of Annals of the Research Institute of Environmental Medicine, pp. 375-387, Nagoya University, Japan, 1989.Graham JM Jr., Meill E.A. Cardiac defects in CHARGE Association, (parent support organization newsletter) CHARGE Accounts, 2(1):2-3, 1991. 12. Sharony R., Pepkowitz S., Hixon H., Machin, G.A., Graham J.M. Jr.: Diprosopus - A pregastrulation defect involving the head, neural tube, heart and diaphragm. Birth Defects: Original Article Series, 29:211-225, 1993. 13. Sharony R., Hixon H., Pepkowitz S., Carlson D., Platt L., Graham J.M. Jr.: Experience with a fetal dysmorphology/pathology service in an academic medical center. Birth Defects: Original Article Series, 29:195-203, 1993. 14. Graham J.M. Jr.: Plagiocephaly-torticollis deformation sequence. Gene Scene, 3(1):3-4, 1998. 15. Lawand C., Prasad, C., Graham, Jr. J.M ., Blake, K.D.: CHARGE association - looking ahead. Canadian Paediatric Surveillance Program Resource Binder. 1999-2002. 16. Blake K., Graham, Jr., J.M ., Prasad C., Smith I.S.: Quarterly Report. Incidence and Prevalence of CHARGE Association/Syndrome. Published by the Canadian Pediatric Surveillance Program (CPSP) 2002 Results: 20-24. http://www.cps.ca/english/CPSP/index.htm 17. Lawand C, Graham JM, Jr, Prasad C, Blake KD (2003). CHARGE association /syndrome: Looking ahead. Published by the Canadian Pediatric Surveillance Program (CPSP) 2003 Resources. http://www.cps.ca/english/CPSP/index.htm 18. Carey J.C ., Curry C.J.R., Grix A.W., Golabi M., Graham, Jr., J.M ., Buehler B.A.: A tribute to Bryan Hall: Festschrift 2003. American Journal of Medical Genetics, 123A:1-4, 2003. Printed January 28, 2015 - Page 30 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 61 of 130 PAGEID #: 42365 EXHIBIT 1 19. Blake K., Graham, Jr., J.M ., Prasad C., Smith I.S.: CHARGE Association/Syndrome (September 2001 through August 2004). Published by the Canadian Pediatric Surveillance Program (CPSP) 2003 Results: 20-24. http://www.cps.ca/english/CPSP/index.htm 20. Blake K., Graham, Jr., J.M ., Prasad C., Smith I.S.: CHARGE Association/Syndrome (September 2001 through August 2004) Final Report. Published by the Canadian Pediatric Surveillance Program (CPSP) 2004 Results: 27-31. http://www.cps.ca/english/CPSP/index.htm 21. Graham J.M ., Jr., Hennkam RC: Preface to Special Issue: Epilepsy and Genetics, European Journal of Medical Genetics 55(5):279-280, 2012. BOOKS AND BOOK CHAPTERS 1. Graham J.M. Jr., Phillips E.L.R., Herman C.S. and Little R.E.: Manual for the Assessment of Fetal Alcohol Effects, Seattle, University of Washington Press, 1982. 2. Graham J.M. Jr., Chapter 20: Congenital anomalies, In: Levine, M.D., Carey, W.B., Crocker, A.C. and Gross, R.T. (Eds.) Developmental Behavioral Pediatrics, Philadelphia, WB Saunders Co., pp. 363-389, 1983. 3. Graham J.M. Jr., Bashir A.S. and Stark R.E., Chapter 40: Communicative disorders, In: Levine, M.D., Carey, W.B., Crocker, A.C. and Gross, R.T. (Eds.) Developmental Behavioral Pediatrics, Philadelphia, WB Saunders Co., pp. 847-864, 1983. 4. Graham J.M. Jr. and Edwards M .J., Chapter 11.3: Teratogenic effects of maternal hyperthermia, In: Gericke GS and Op't Hof J (Eds.) Genetic Perspectives in Fetal and Neonatal Medicine, Pretoria, Republic of South Africa, Haum Publishers, pp 44-56, 1983. 5. Graham J.M. Jr., Chapter 11.4: Adverse effects from uterine restrictive influences: Fetal deformation, In: Gericke GS and Op't Hof J. (Eds.) Genetic Perspectives in Fetal and Neonatal Medicine, Pretoria, Republic of South Africa, Haum Publishers, pp 56-93, 1983. 6. Graham J.M. Jr. and Edwards S.T., Chapter 17: Congenital malformations of the alimentary tract. In: Walker WA and Watkins J (Eds.) Nutrition in Pediatrics Basic Sciences and Clinical Application, Boston, Little Brown and Co., pp 675-705, 1985. 7. Graham J.M. Jr., Current issues in alcohol teratogenesis. In: Shenker JG and Weinstein D (Eds) The Intrauterine Life-Management and Therapy, Amsterdam, Elsevier Science Publishers, pp 383-388, 1986. 8. Graham J.M. Jr., Smith's Recognizable Patterns of Human Deformation, 2nd Edition, Philadelphia, W.B. Saunders Co., 1988. 9. Rimoin D.L. and Graham J.M. Jr., Chapter 16: Short Stature. In: Rimoin D.L. and Emery A.E.H. (Eds.) Principles and Practice of Medical Genetics, Edinburgh, U.K., Churchill Livingstone, Vol 1,pp 225-234, 1990. Printed January 28, 2015 - Page 31 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 62 of 130 PAGEID #: 42366 EXHIBIT 1 10. Cooley, W.C., Graham, E.S., Moeschler, J.B. and Graham, J.M. Jr.: Reactions of mothers and medical professionals to a film of parents of persons with Down syndrome, Chigier E (Ed.) Looking Up At Down Syndrome, London, England, Freund Publishing House Ltd, pp 109-117, 1990. 11. Charman CE, and Graham J.M. Jr., Hypothalamic hamartoblastoma syndrome, congenital, Buyse, M.L. (Ed.), Birth Defects Encyclopedia, Cambridge MA, Blackwell Scientific Publications, pp 932-934, 1990. 12. Graham J.M. Jr., Rawsley B.E., Nordgren R.E., and Ionasescu I., Emery-Dreifuss syndrome, Buyse, M.L., (Ed.), Birth Defects Encyclopedia, Cambridge MA, Blackwell Scientific Publications, pp 613-614, 1990. 13. Halal F., Moeschler J.B. and Graham J.M. Jr., Radial-renal-ocular syndrome, Buyse ML (Ed.), Birth Defects Encyclopedia, Cambridge MA, Blackwell Scientific Publications, pp 1455-1456, 1990. 14. Graham J.M. Jr., Craniofacial deformation, Gorlin R.J., Cohen M.M., Jr., and Levin L.S. (Eds), Syndromes of the Head and Neck, 3rd edition, New York, Oxford University Press, pp 1-4, 1990. 15. Gibbs B., Moeschler J.B., Graham J.M. Jr., and Andrew C. Readings and Resources: A Guide for Educational and Medical Professionals Caring for Children with Genetic and Prenatally Determined Conditions. Hanover, NH, Clinical Genetics and Child Development Center, pp 1 144, 1991. 16. Graham J.M. Jr., Chapter 25: Congenital anomalies, In: Levine, M.D., Carey, W.B., Crocker, A.C. (Eds.) Developmental Behavioral Pediatrics, 2nd Edition, Philadelphia, WB Saunders Co., pp 229-243, 1992. 17. Bashir, A.S, Stark, R.E, Graham J.M. Jr., Chapter 64: Communication disorders, In: Levine, M.D., Carey, W.B., Crocker, A.C. (Eds.) Developmental Behavioral Pediatrics, 2nd Edition, Philadelphia, WB Saunders Co., pp 557-568, 1992. 18. Graham J.M. Jr., Donahue K.C., Hall J.G.: Human anomalies and cultural practices. In: Human Malformations and Related Anomalies, (Eds): Stevenson R. and Hall J., New York, Oxford University Press, Vol 1:169-181, 1993. 19. Graham J.M ., Jr.: Chapter 3: When is it best to be born? A morphological perspective: craniofacial deformations. In: Amiel-Tison, C. and Stewart, A., The Newborn Infant: One Brain for Life, Paris, INSERM Press, pp 23-38, 1994. 20. Graham J.M. Jr. and Rimoin D.L.: Chapter 39: Abnormal body size and proportion. In: Rimoin D.L., Connor J.M ., Pyeritz R.E., Emery A.E.H. (Eds.), Principles and Practice of Medical Genetics (3rd Edition), New York N Y, Churchill Livingstone, pp 737-752, 1996. 21. Graham J.M. Jr.: Craniofacial deformation. Balliere's Clinical Paediatrics, 6:293-315, 1998. Printed January 28, 2015 - Page 32 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 63 of 130 PAGEID #: 42367 EXHIBIT 1 22. Ming J.E., Stiehm E.R., Graham J.M. Jr. Chapter 9: Syndromes associated with immunodeficiency, Advances in Pediatrics, 46:271-351, 1999. 23. Graham, Jr., J.M.: Deformaciones craneofaciales. In Sola, A., Rogido, M. Cuidados Especiales del Feto y el Recin Nacido. Buenos Aires, Cientfica Interamericana, p184-188, 2000. 24. Graham, Jr., J.M , Rimoin, D.L.: Alteraciones del Crecimiento. In Sola, A., Rogido, M. Cuidados Especiales del Feto y el Recin Nacido. Buenos Aires, Cientfica Interamericana,. p 189-196, 2000. 25. Cooley, W.C., Graham, Jr., J.M.: Down Syndrome. In: Stockman, J.A., Lohr, J.A., (Eds.), Essence of Office Pediatrics. Philadelphia PA, W.B. Saunders Co., p. 117, 2001. 26. Graham J.M. Jr. and Rimoin D.L.: Chapter: Abnormal body size and proportion. In: Rimoin D.L., Connor J.M ., Pyeritz R.E., Emery A.E.H. (Eds.), Principles and Practice of Medical Genetics (4th Edition), New York NY, Churchill Livingstone, pp 1066-1082, 2002. 27. Graham J.M. Jr., Chapter: Mixoploidy. In: Creighton T.E. (Ed.), Wiley Encyclopedia of Molecular Medicine, New York NY, John Wiley & Sons, pp. 2100-2103, 2002. 28. Graham J.M. Jr. FG Syndrome. In: The NORD Guide to Rare Disorders. Philadelphia, PA. Lippincott Williams & Wilkins, pp 193-194, 2003. 29. Graham J.M. Jr. Hallermann-Streiff Syndrome. In: The NORD Guide to Rare Disorders. Philadelphia, PA. Lippincott Williams & Wilkins, p 202, 2003. 30. Graham J.M. Jr. CHARGE Syndrome. In: The NORD Guide to Rare Disorders. Philadelphia, PA. Lippincott Williams & Wilkins, pp 167-168, 2003. 31. Visootsak J, Graham, Jr., JM; Klinefelter syndrome and its variants. Orphanet encyclopedia, March 2003: http://www.orpha.net/data/patho/GB/uk-KS.html 32. Ming J.E., Graham Jr., J.M.: Chapter 24: Genetic disorders, including syndromic immunodeficiencies. In: Stiehm E.R., Ochs H.D., Winkelstein J.A. (Eds.), Immunologic Disorders in Infants and Children. Fifth Edition, W. B. Saunders Co., pp 785-819, 2004. 33. Simpson J.L., Graham Jr., J.M ., Samango-Sprouse C., Swerdloff R.: Chapter 28, Klinefelter Syndrome. In: Cassidy S.B., Allanson J.E. (Eds.), Management of Genetic Syndromes. 2nd Edition, Wiley-Liss, Hoboken NJ, pp 323-333, 2005. 34. Graham J.M. Jr.: Chapter 7: Skull. In: Human Malformations and Related Anomalies, (Eds): Stevenson R.E. and Hall J.G , 2ndEdition, New York, Oxford University Press, pp 221-265, 2005. 35. Visootsak J, Graham, Jr., JM; Klinefelter syndrome and its variants. Orphanet encyclopedia, September 2006: http://www.orpha.net/data/patho/GB/uk-KS.html Printed January 28, 2015 - Page 33 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 64 of 130 PAGEID #: 42368 EXHIBIT 1 36. Graham J.M. Jr. and Rimoin D.L.: Chapter 41: Abnormal body size and proportion. In: Rimoin D.L., Connor J.M ., Pyeritz R.E., Korf B.R. (Eds.), Emery and Rimoin's Principles and Practice of Medical Genetics (5th Edition), New York N Y, Churchill Livingstone, pp 948-963, 2007. 37. Mortier G., Graham J.M. Jr. and Rimoin D.L.: Chapter 17: Short Stature Syndromes. In: Kelnar C. J. H., Savage M.O., Saenger P., and Cowell C.T. (Eds.), Growth Disorders (2nd Edition), Hodder Arnold Press, London, UK, pp 261-282, 2007. 38. Graham J.M. Jr., Smith's Recognizable Patterns of Human Deformation, 3rd Edition, Philadelphia, Elsevier-W.B. Saunders Co., Philadelphia, PA, 2007. 39. Graham, JM Jr..: Chapter 1. Deformations and Disruptions. In: Hennekam RCM, Allanson J, Krantz I. (Eds) Gorlin's Syndromes of the Head and Neck. (5th Edition), Oxford University Press, New York NY, pp 3-24, 2010. 40. Visootsak J., Graham Jr., J.M ., Samango-Sprouse C., Swerdloff R. Simpson J.L.: Chapter 33, Klinefelter Syndrome. In: Cassidy S.B., Allanson J.E. (Eds.), Management of Genetic Syndromes. 3rd Edition, Wiley-Liss, Hoboken NJ, pp 479-494, 2010. 41. Graham JM Jr.: B Hale, A. Scialli, MS Tassinari (Eds). Chapter 6. How do genes affect the risk of having a child with a birth defect? Teratology Primer 2ndEdition, Teratology Society, pp1719. 2010. 42. Nemec S.F., Brugger P.C., Kasprian G., Nemec U., Graham J.M ., Jr., Prayer D.: The skeleton and musculature. In Prayer D. (Ed.). Medical Radiology Diagnostic Imaging: Fetal MRI, 1st Edition, Springer,-Verlag, Berlin Heidelberg Germany, pp 235-246, 2011. 43. Sanchez-Lara, P.A., Graham Jr., J.M.: Congenital Anomalies of the Skull. In: Swaiman K., Ashwal S., FerrieroD., SchorN. (Eds.), Swaiman's Pediatric Neurology: Priniciples and Practice 5th Edition, Elsevier, New York NY, pp 247-262, 2012. 44. Graham J.M. Jr. Burkardt D.D. and Rimoin D.L.: Chapter 38: Abnormal body size and proportion. In: Rimoin D.L., Pyeritz R.E., Korf B.R. (Eds.), Emery and Rimoin' s Principles and Practice of Medical Genetics, 6th Edition, New York NY, Elsevier, pp 1022-1045, 2013. 45. Graham J.M. Jr. CHARGE Syndrome. In: The NORD Guide to Rare Disorders. Philadelphia, PA. Lippincott Williams & Wilkins, 2013. 46. Graham J.M. Jr. Hallermann-Streiff Syndrome. In: The NORD Guide to Rare Disorders. Philadelphia, PA. Lippincott Williams & Wilkins, 2013. 47. Graham J.M. Jr. Larsen Syndrome. In: The NORD Guide to Rare Disorders. Philadelphia, PA. Lippincott Williams & Wilkins, 2013. 48. Ming J.E., Graham Jr., J.M.: Chapter 12: Genetic syndromes with evidence of immune deficiency. In: Sullivan K.E. and Stiehm E.R.(Eds.), Stiehm's Immune Deficiencies. 6th Edition, New York, NY, Elsevier Inc, pp 281-324, 2014. Printed January 28, 2015 - Page 34 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 65 of 130 PAGEID #: 42369 EXHIBIT 1 49. Graham J.M. Jr., Sanchez-Lara, P.A.: Chapter__ : Skull. In: Human Malformations and Related Anomalies, Stevenson R.E., Hall J.G ., Everman D. and Solomon B., 3rd Edition, New York, Oxford University Press, in press, 2015. 50. Graham J.M. Jr., Sanchez-Lara P.A.: Smith's Recognizable Patterns of Human Deformation, 4th Edition, Philadelphia, Elsevier-W.B. Saunders Co., Philadelphia, PA, in press 2015. 51. Sanchez-Lara, P.A., Graham Jr., J.M.: Chapter 31: Congenital Anomalies of the Skull. In: Swaiman K., Ashwal S., Ferriero D., Schor N., Finkel R., Gropman A., Pearl P., Shevell M. (Eds.), Swaiman's Pediatric Neurology: Priniciples and Practice 6th Edition, Elsevier, New York NY, in prepraration, 2017. L etters to the E ditor 1. Smith D.W., and Graham J.M. Jr.: Fetal alcohol syndrome in child whose parents had stopped drinking. Lancet 2(8141):527, 1979. 2. Graham J.M. Jr., Wertelecki W, O'Conner J.E. and Cohen M.M. Choanal atresia with Down syndrome. Journal of Pediatrics, 98:664, 1981. 3. Graham J.M. Jr., and Smith D.W. Dominantly-inherited pterygium colli. Journal of Pediatrics, 98:664-665, 1981. 4. Frank D.A., Graham J.M. Jr. and Smith D.W. Adoptive children in a dysmorphology clinic: Implications for evaluation of children before adoption. Pediatrics, 68:744-745, 1981. 5. Graham J.M. Jr., Neurologic findings with maternal hyperthermia - Reply. Pediatrics, 69:128 129, 1982. 6. Graham J.M. Jr., and Frank D.A. Dysmorphology and Adoptions - Reply. Pediatrics, 69:665, 1982. 7. Pagon R.A., Zonana J, and Graham J.M. Jr. CHARGE Association. Pediatrics, 70:827-828, 1982. 8. Graham J.M. Jr., Rawnsley E.F., Simmons G.M. Crow H.C. Confirmation of xeroradiography as an important postmortem fetal diagnostic technique. American Journal of Obstetrics and Gynecology, 153:347, 1985. 9. Cooley W. C., Graham J. M. Jr., Letter to the editor: Clinical note concerning smaller caliber of subglottic region in children with Down syndrome. Clinical Pediatrics, 30(11):646, 1991. 10. Graham J.M. Jr., Letter to the editor: Life before death. Clinical Pediatrics, 14(1):87, 1994. 11. Biesecker L.G., Topf K., Graham J.M. Jr., Letter to the editor: Familial Pallister-Hall syndrome, Journal of Medical Genetics, 31(9):740, 1994. Printed January 28, 2015 - Page 35 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 66 of 130 PAGEID #: 42370 EXHIBIT 1 12. Bacino C.A., Graham J.M. Jr., Letter to the editor: Clinical and molecular studies in full trisomy 22: Further delineation of the phenotype and review of the literature. Reply to Dr. Hirschhorn. American Journal of Medical Genetics, 62:99, 1995. 13. Bacino C.A., Graham J.M. Jr., Letter to the editor: Clinical and molecular studies in full trisomy 22: Further delineation of the phenotype and review of the literature. Reply to Dr. Robinson and Dr. Kalousek. American Journal of Medical Genetics, 62:101, 1995. 14. Wang M., Matthews K.R., Imaizumi K., Beiraghi S., Blumberg B., Scheuner M., Graham, Jr. J.M ., and Godfrey M., Correspondence: P1148A in fibrillin-1 is not a mutation anymore. Nature Genetics 15:12, 1997. 15. Allanson J., Hunter A., Cassidy S., Curry C., Donnai D., Fraser C., Gorlin R., Graham, Jr. J.M., Hall B., Hall J., Jones K.L., Stevenson R., and Winter R., Letter to the Editor: Photographic documentation of syndrome diagnosis. American Journal of Medical Genetics 68:487, 1997. 16. Aylsworth A., Graham, Jr. J.M ., Hall J.G ., Hoyme H.E., Jones K.L., Stevenson R.E., Correspondence: Morphogenesis: Re: Clinical, natural history, and imaging information on patients included in reports. American Journal of Medical Genetics 119A:93, 2003. 17. Blake K., Graham, Jr., J.M ., Prasad C.: Reply to Letter to the Editor by Lowry et al.: An epidemiological analysis of CHARGE syndrome: preliminary results from a Canadian study (Issekutz et al., 2005). American Journal of Medical Genetics, 139A:170-171, 2005. 18. Conway R, Danielpour M, Graham Jr., J.M.: Editorial and Response: Macrocephaly-cutis marmorata telangiectatica congenita. Journal of Neurosurgery (4 Suppl Pediatrics), 106:293-295, 2007. Doctoral Thesis Graham J.M. Jr. Communicative skills in X X Y boys. Division of Communicative Disorders, Department of Health Services Administration, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland, 1981. Doctoral Thesis Advisees Weng E.Y. Review of Beckwith-Wiedemann syndrome: A prototypical fetal overgrowth disorder. Doctoral Thesis, U CLA Medical School, Los Angeles, CA, 1995. Reviews 1. Little R.E., Graham J.M. Jr. and Samson H.H.: Fetal alcohol effects in humans and animals. Advances in Alcohol and Substance Abuse, 1:103-125, 1982. 2. Graham J.M. Jr., Causes of limb-reduction defects: The contribution of fetal constraint and/or vascular disruption, Clinics in Perinatology, 13:575-591, 1986. Printed January 28, 2015 - Page 36 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 67 of 130 PAGEID #: 42371 EXHIBIT 1 3. Graham J.M. Jr., Rotter J.I., Riccardi V.M. et al: Report of the task force on teaching human genetics in North American Medical Schools. American Journal of Human Genetics, 44:161 165, 1989. 4. Charman C.E., Graham J.M. Jr.: Report of the First Information and Education Committee Human Genetics Teaching Forum. American Journal of Human Genetics 44:605-607, 1989. 5. Rimoin D.L., and Graham J.M. Jr.: Syndromes associated with growth deficiency. Acta Paediatr. Scan. (Suppl) 349:3-10, 1989. 6. Graham J.M. Jr. (Guest Editor), Fetal Dysmorphology, Clinics in Perinatology, 17(3), September, 1990. 7. Graham J.M. Jr. (Guest Editor), Fetal Clinical Genetics, Clinics in Perinatology, 17(4), December, 1990. 8. Graham J.M. Jr., Otto, C., Clinical approach to prenatal detection of human structural defects, Clinics in Perinatology, 17(3):513-546, September, 1990. 9. Edwards M .J., Graham J.M. Jr., Posterior nuchal cystic hygroma, Clinics in Perinatology, 17(3):611-640, September, 1990. 10. Graham JM Jr., Clinical approach to human structural defects, Seminars in Perinatology, 15(1)Suppl 1:2-15, 1991. 11. Sharony R., Graham J.M. Jr. Identification of fetal problems associated with anticonvulsant usage and maternal epilepsy. Obstetrics and Gynecology Clinics of North America, 18(4):933951, 1991. 12. Graham J.M. Jr., Curry C.J.R., Hoyme H.E., Stevenson R., Hall J.G. Fellowship and career development in dysmorphology and clinical genetics. Pediatric Clinics of North America, 39(2), 349-362, 1992. 13. Graham J.M. Jr. Introduction: Papers on Brachmann-deLange syndrome presented at the 12th Annual David W. Smith Workshop on Morphogenesis and Malformations. American Journal of Medical Genetics, 47:939, 1993. 14. Adams J, Buttar H.S., Chambers C., Collins T.F.X., Graham, Jr., J.M ., Jones K.L., Kweder S., Lammer E., Mitala J., Polifka J.E., and Schwetz B.A.: Statement of the Public Affairs Committee of the Teratology Society on Thalidomide. Teratology 62:172-173, 2000. 15. Adams J, Bittner P., Buttar H.S., Chambers C.D., Collins T.F.X., Daston G.P., Filkins K., Flynn T.J., Graham, Jr., J.M ., Jones K.L., Kimmel C., Lammer E., Librizzi R., Mitala J., and Polifka J.E.: Statement of the Public Affairs Committee of the Teratology Society on the Fetal Alcohol Syndrome. Teratology, 66:344-347, 2002. Printed January 28, 2015 - Page 37 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 68 of 130 PAGEID #: 42372 EXHIBIT 1 16. Graham J.M. Jr., Kathleen K. Sulik (Guest Editors) Introduction: Twelth Robert J. Gorlin Conference on Dysmorphology, American Journal of Medical Genetics 122A:281-282, 2003. 17. Carey J.C ., Curry C.J.R., Grix A.W., Golabi M., Graham J.M. Jr., Buehler B.A.: A tribute to Bryan D. Hall: Festscrift 2003. American Journal of Medical Genetics, 123A:1-4, 2003. 18. Graham J.M. Jr., Hennekam R.C.M.: Preface to Special Issue on Epilepsy and Genetics, European Journal of Medical Genetics, 55(5): 279-280, 2012. ABSTRACTS AND PRESENTATIONS 1. Graham J.M. Jr.: The effect of d-amphetamine sulfate on susceptibility to audiogenic seizures in DBA/2J mice. Texas Reports on Biology and Medicine, 30:207, 1972. 2. Graham J.M. Jr.: Schreiber R.A. and Zemp J.W. The effect of d-amphetamine sulfate on susceptibility to audiogenic seizures in DBA/2J mice. Fifth International Congress of Pharmacology, San Francisco CA, July 23-28, 1972. 3. Graham J.M. Jr., Schreiber R.A. and Zemp J.W.: The effects of d-amphetamine sulfate on susceptibility to audiogenic seizures in DBA/2J and C57BL/6J mice. Texas Reports on Biology and Medicine, 31:570-571, 1973. 4. Graham J.M. Jr., Schreiber R.A. and Zemp J.U.: D-amphetamine reduces the severity of soundinduced seizures in DBA/2J and C57BL/6J mice. Third Annual Meeting of the Society for Neuroscience, San Diego CA, November 7-10, 1973. 5. Wertelecki W, Graham J.M. Jr., Sergovich F and Granoff D.: The importance of clinical recognition of triploidy. Proceedings of the Fourteenth International Congress of Pediatrics, pp. 85-87, 1974. 6. Graham J.M. and Smith D.W.: The neonate with an engaging head: The soft-headed baby. Clinical Research 27:118A, 1979. 7. Graham J.M. Jr. and Smith D.W.: Dominantly inherited pterygium colli: Cervical lymphectasia malformation complex. Clinical Research 27:101A, 1979. 8. Graham J.M. Jr., DeSaxe M and Smith D.W.: Sagittal craniostenosis: Fetal head constraint as one possible cause. Pediatric Research, 13:485, 1979. 9. Graham J.M. Jr., and Smith D.W.: Parietal cranioteobes in the neonate: Its origin and relevance. Pediatric Research, 13:485, 1979. 10. Graham J.M. Jr., DeSaxe M and Smith D.W.: Sagittal craniostenosis: Fetal head constraint as one possible cause. Teratology, 19:27-28A, 1979. 11. Graham J.M. Jr., De Saxe M, Badura R.J. and Smith D.W.: Fetal head constraint as one possible cause for craniostenosis. 1979 Birth Defects Conference, Chicago IL, June 24-27, 1979. Printed January 28, 2015 - Page 38 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 69 of 130 PAGEID #: 42373 EXHIBIT 1 12. Graham J.M. Jr., Koskinen-Moffett L.K., Moffett B.C. and Smith D.W.: Fetal head constraint: A common cause for craniostenosis. Clinical Research, 28:116A, 1980. 13. Graham J.M. Jr., Miller M.E., Stephan J.M. and Smith D.W.: Limb reduction anomalies and early in-utero limb compression. Clinical Research 28:116A, 1980. 14. Pagon R.A., Graham J.M. Jr., Sybert V.P.: The CHARGE association. Clinical Research, 28:522, 1980. 15. Graham J.M. Jr., Hoehn H.W., Lin M.S. and Smith D.W.: Diploid-triploidy mosaicism: Clinical and cytogenetic features. Pediatric Research, 14:522, 1980. 16. Graham J.M. Jr., Miller M.E., Stephan M .J. and Smith D.W.: Limb reduction anomalies and early in-utero limb compression. Pediatric Research, 14:585, 1980. 17. Graham J.M. Jr., and Smith D.W.: Pterygium colli as a consequence ofjugular lymphatic obstruction malformation sequence: Pathogenesis and report of dominant inheritance. Pediatric Research, 14:585, 1980. 18. Miller M.E., Graham J.M. Jr., Higginbottom M.C. and Smith D.R.: Conditions of limb reduction and body wall closure defects: Features in the spectrum of early amnion rupture malformation sequence. Pediatric Research 14:586, 1980. 19. Pleet H.B., Graham J.M. Jr., Harvey M.A. and Smith D.W.: Patterns of malformations resulting from the teratogenic effects of first trimester hyperthermia. Pediatric Research, 14:587, 1980. 20. Pagon R.A., Graham J.M ., Jr., Yong S and Kalina R.E.: Coloboma and multiple anomalies - ? an autosomal dominant disorder. Association for Research in Vision and Ophthalmology Meeting, Orlando FL, May 5-9, 1980. 21. Graham J.M. Jr., Miller M.E., Higginbottom M .C., Stephen M .J. and Smith D.W.: Early in-utero compression as a cause for limb deficiency. 1980 Birth Defects Conference, New York City, June 8-11, 1980. 22. Graham J.M. Jr., Smith D.W., Koskinen-Moffett L., Stuntz J.T., Loeser J.D., Clarren S.K., and Moffett B.C.: Craniostenosis caused by fetal head constraint: Correlation of etiology with sutural histology and response to surgery. 1980 Birth Defects Conference, New York City, June 8-11, 1980. 23. Miller M.E., Graham J.M. Jr., Higginbottom M.C. and Smith D.W.: Compressionrelated defects from early amnion rupture: Evidence for mechanical teratogenesis. 1980 Birth Defects Conference, New York City, June 8-11, 1980. 24. Jung J.H., Graham J.M. Jr., Schultz N and Smith D.W.: Monozygotic twinning: The problem of congenital hydranencephaly/porencephaly. 1980 Birth Defects Conference, New York City, June 8-11, 1980. Printed January 28, 2015 - Page 39 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 70 of 130 PAGEID #: 42374 EXHIBIT 1 25. Graham J.M. Jr., Miller M.E., Stephan M .J. and Smith D.W.: Limb reduction anomalies and early in-utero limb compression. Teratology 21:40A, 1980. 26. Graham J.M. Jr., Higginbottom M.C. and Smith D.: Pre-axial polydactyly of the foot associated with early amnion rupture: Evidence for mechanical teratogenesis? Conference on Malformations and Morphogenesis, San Diego CA, September 4-6, 1980. 27. Graham J.M. Jr., Hoehn H., Lin M.S. and Smith D.W.: Diploid-triploid mixoploidy: Clinical and cytogenetic features. Conference on Malformations and Morphogenesis, San Deigo CA, September 4-6, 1980. 28. Smith D.W., Harvey M .A.S., Bunn B.S. and Graham J.M. Jr.: Specific diagnoses and prognoses in SGA infants. Conference on Malformations and Morphogenesis, San Diego CA, September 4 6, 1980. 29. Pagon R.A., Graham J.M. Jr., Zonana J. and Yong S.L.: The CHARGE association, American Society of Human Genetics Meeting, New York City, September 24-27, 1980. 30. Carey J.C ., Smith D.W., Graham J.M. Jr., Thain W.S., Haas J.E. and Hall B.D.: New syndrome of developmental/growth retardation, coarse facies, and unusual hands. Clinical Research, 29:130A, 1981. 31. VanAllen M.I., Smith D.W. and Graham J.M. Jr.: Twin reversed arterial perfusion sequence. Clinical Research, 29:133A, 1981. 32. Smith D.W., Harvey M .A.S., Bunn B.S. and Graham J.M. Jr.: Specific diagnoses and prognoses in SGA infants. Clinical Research, 29:133A, 1981. 33. Jung J.H., Graham J.M. Jr., Schultz N. and Smith D.W.: Vascular disruption associated with monozygotic twinning: A possible cause of congenital hydranencephaly porencephaly. Clinical Research 29:132A, 1981. 34. Graham J.M. Jr., Bashir A.S., Walzer S., Start R.E. and Gerald P.S.: Communication skills among unselected X X Y boys. Pediatric Research, 15:562, 1981. 35. Graham J.M. Jr., Stephen T.D., Siebert Jr. and Smith D.W.: Determinants in the morphogenesis of muscle tendon insertions. Pediatric Research 15:643, 1981. 36. Graham J.M. Jr., Darby B.L., Barr H.M., Smlth D.W. and Streissguth A.P.: Longterm effects of moderate alcohol consuption during pregnancy. Pediatric Research, 15:643, 1981. 37. Graham J.M. Jr., Clarren S.K., Koskinen-Moffett L., Stuntz J.T., Loeser J.D. and Smith D.W.: Craniostenosis: Correlation of etiology with sutural histology and response to surgery. Pediatric Research, 15:662, 1981. 38. Smith D.W., Harvey M .A.S., Bunn B.S. and Graham J.M. Jr.: Specific diagnosis and prognoses in SGA infants. Pediatric Research, 15:646, 1981. Printed January 28, 2015 - Page 40 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 71 of 130 PAGEID #: 42375 EXHIBIT 1 39. Van Allen M.I., Smith D.W. and Graham J.M. Jr.: Twin reversed arterial perfusion sequence. Teratology, 23:67A, 1981. 40. Graham J.M. Jr., Crow H.C., Rawnsley E.F. and Hoefnagel D.: Use of xeroradiography in the study of abortuses. Teratology, 23:37A, 1981. 41. Graham J.M. Jr., Darby B.L., Barr H.M., Smith D.W. and Streissguth A.P.: Longterm effects of alcohol consumption during pregnancy. Teratology, 23:38A, 1981. 42. Graham J.M. Jr., Clarren S.K., Koskinen-Moffett J.T., Loeser J.D. and Smith D.W.: Craniostenosis: Correlation of etiology with sutural histology and response to surgery. Teratology 23:38A, 1981. 43. Graham J.M. Jr., Stephens T.D., Siebert Jr. and Smith D.W.: Determinants in the morphogenesis of muscle tendon insertions. Teratology, 23:37A, 1981. 44. Smith D.W., Harvey M .A.S., Bunn B.S. and Graham J.M. Jr.: Specific diagnoses and prognoses in SGA infants. Teratology 23:63A, 1981. 45. Graham J.M. Jr., Marin-Padilla M and Hoefnagel D.: Disruptive vascular defects associated with Catergot ingestion during pregnancy. 1981 Birth Defects Conference, San Diego CA, June 14 17, 1981. 46. Graham J.M. Jr., Bashir A.S., Walzer S, Stark R.E. and Gerald P.S.: Communications skills and reading and spelling abilities in unselected X X Y boys. 1981 Birth Defects Conference, San Diego CA, June 14-17, 1981. 47. Graham J.M. Jr. and Hoefnagel D.: Bilateral thumb polydcatyly in a girl whose mother shows the Fromont anomaly. Conference on Malformations and Morphogenesis. Hanover, NH, August 23-25, 1981. 48. Marin-Padilla M., Graham J.M. Jr. and Simmons G.H.: Extrinsic vascular disruptions and unilateral limb malformations. Conference on Malformations and Morphogenesis. Hanover, NH, Hampshire, August 23-25, 1981. 49. Graham J.M. Jr., Stephens T.D., Siebert Jr. and Smith D.W.: Determinants in the morphogenesis of muscle tendon insertions. David W. Smith Festscrift. Lake Wilderness Continuing Educational Center, Maple Valley WA, September 18-20, 1981. 50. Koskinen-Moffett LK, Moffett BC and Graham J.M. Jr.: Cranial synostosis and intrauterine compression: A developmental study of human sutures. International Conference on Factors and Mechanisms Influencing Bone Growth. U CLA Center for Health Sciences, Los Angeles CA, January 5-7. 1981. 51. Graham J.M. Jr., Bashir A.S., Walzer S., Stark R.E., Tallal P. and Gerald P.S.: Auditory processing abilities in unselected X X Y boys. Clinical Research, 30:118A, 1982. Printed January 28, 2015 - Page 41 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 72 of 130 PAGEID #: 42376 EXHIBIT 1 52. Graham J.M. Jr. and Hoefnagel D.: Thumb polydactyly as part of the range of genetic expression for preaxial limb deficiency. Clinical Research, 30:133A, 1982. 53. Graham J.M. Jr., Crow H.C., Rawnsley E.F. and Hoefnagel D.: Enhanced visualization of soft tissues in the study of aborted fetuses through the use of xeroradiography. Teratology 24:45AA, 1982. 54. Graham J.M. Jr.: Limb anomalies as a consequence of spatially-restricting uterine environments. Third International Conference on Limb Development and Regeneration. Storrs, CT, June 27July 2, 1982. 55. Graham J.M. Jr.: Limb anomalies as a consequence of spatially- restricting uterine environments. International Conference on Prevention of Mental and Physical Congenital Anomalies, Strasbourg, France, October 11-16, 1982. 56. Graham J.M. Jr.: Effects of alcohol consumption during pregnancy. International Conference on Prevention of Mental and Physical Congenital Anomalies. Strasbourg, France, October 11-16, 1982. 57. Graham J.M. Jr., Ferm R., Ferm V.H.: Maternal binge drinking as a possible cause for neural tube defects. Clinical Research, 31:128A, 1983. 58. Gang D., Wright J., Edwards W., Graham J.M. Jr.: Extensive vertex cutis aplasia associated with atresia of the gall bladder and vascular anomalies. Clinical Research, 31:127A, 1983. 59. Graham J.M. Jr., Perl D., O'Keefe T., Rawnsley E., Little G.A.: Apparent familial recurrence of hypothalamic hamartoblastoma syndrome. Clinical Research 31:128A, 1983. 60. Graham J.M. Jr., Crow H.C., Rawnsley E.F., Simmons G.M., Hoefnagel D.: Enhanced visualization of soft tissues in the study of aborted fetuses through the use of xeroradiography. Clinical Research 31:128A, 1983. 61. Graham J.M. Jr., Ferm R., Ferm V.H.: Maternal binge drinking as a possible cause for neural tube defects. Pediatric Research, 17:299A, 1983. 62. Graham J.M. Jr., Crow H.C., Rawnsley E.F., Simmons G.M., Hoefnagel D.: Enhanced visualization of soft tissues in the study of aborted fetuses through the use of xeroradiography. Pediatric Research, 17:299A, 1983. 63. Graham J.M. Jr., Ferm R., Ferm V.H.: Maternal binge drinking as a possible cause for neural tube defects. Proceedings of the Greenwood Genetic Center, 2:98, 1983. 64. Wright J., Gang D., Edwards W. and Graham J.M. Jr.: Extensive vertex cutis aplasia associated with atresia of the gall bladder and vascular anomalies. Proceedings of the Greenwood Genetic Center, 2:103-104, 1983. Printed January 28, 2015 - Page 42 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 73 of 130 PAGEID #: 42377 EXHIBIT 1 65. Graham J.M. Jr., Perl D., O'Keefe T., Rawnsley E. and Little G.A.: Apparent familial recurrence of hypothalamic hamartoblastoma syndrome. Proceedings of the Greenwood Genetic Center, 2:117-118, 1983. 66. Wertelecki W., Graham J.M. Jr., Sergovich F.R.: Trisomy 22 mosaicism: Turner stigmata and asymmetry. Proceedings of the Greenwood Genetic Center, 2:136-137, 1983. 67. Graham J.M. Jr., Crow H.C. Rawnsley E.F., Simmons G.M. and Hoefnagel D.: Enhanced visualization of soft tissues in the study of aborted fetuses through the use of xeroradiography. Proceedings of the Greenwood Genetic Center, 2:133, 1983. 68. Graham J.M. Jr., Bashir A.S., Walzer S., Stark R.E.: Left hemisphere deficits in unselected X X Y Boys. Behavioral Genetics, 13:536, 1983. 69. Graham J.M. Jr., Ferm R., Ferm V.H.: Neural tube defects induced by alcohol and/or heat in golden hamster fetuses. Teratology, 27:45A-46A, 1983. 70. Graham J.M. Jr., Ferm R. and Ferm V.H.: Folate supplementation does not prevent alcohol-or heat-induced neural tube defects. Proceedings of the Greenwood Genetic Center 3:116-117, 1984. 71. Graham J.M. Jr., Boyle W., Troxell J., Cullity G.J. and Beckwith J.B. Bilateral neoplastic kidney disease, pulmonary cystic disease, and fetal macrosomia: A spectrum of developmental abnormalities. Pediatric Research 18:305A, 1984. 72. Graham J.M. Jr., Ferm V.H. and Layton W.: Folate supplementation does not prevent neural tube defects induced by alcohol or heat. Pediatric Research 18:305A, 1984. 73. Graham J.M. Jr., Rawnsley E.F. and Sulik K.K. Vitamin A teratogenesis in a sensitive genetic background. Pediatric Research 18:305A, 1984. 74. Graham J.M. Jr., Troxell J., Boyle W. and Beckwith J.B.: Bilateral neoplastic kidney disease and pulmonary cystic disease: A spectrum of developmental abnormnalities. Teratology 29:32A, 1984. 75. Graham J.M. Jr., Struckmeyer C.L. and Hallowell C.: Dominantly inherited unilateral ectrodactyly: Case report and review of the literature. American Journal of Human Genetics, 36(Supple):53, 1984. 76. Graham J.M. Jr., Harris J., Frank J.E., Little G.A. and Klein R.Z.: Syndromes associated with polydactyly and hypopituitarism. Pediatric Research 19:325A, 1985. 77. Graham J.M. Jr., Meill E., Pagon R.A., Siebert J.R. and Kaplan L.: Conotruncal defects in CHARGE Association: Evidence for neural crest involvement. Pediatric Research 19:325A, 1985. Printed January 28, 2015 - Page 43 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 74 of 130 PAGEID #: 42378 EXHIBIT 1 78. Graham J.M. Jr., Frank J.E., Harris M., Klein R.Z., Saunders R.L., Binder M. and Fratkin J.D.: Congenital hypothalamic hamartoblastoma syndrome: Natural history and etiologic considerations. Tetratology 31:65A, 1985. 79. Graham J.M. Jr., Meill E., Pagon R.A., Siebert J.R. and Kaplan L.C.: Cardiac features of the CHARGE association: Support for involvement of the neural crest. Proceedings of the Greenwood Genetic Center 4:82-83, 1985. 80. Graham J.M. Jr., Harris M., Frank J.E., Little G.E. and Klein R.Z.: Congenital hypothalamic hamartoblastoma syndrome: Natural history and genetic implications. Fourth International Clinical Genetics Seminar, Athens, Greece, May 22-25, 1985. 81. Graham J.M. Jr., Darby B.L., Barr H.M., Streissguth A.P. and Hanson J.M.: Fetal alcohol effects on human morphogenesis: Discriminating features in a prospective study. The 2nd International Symposium: The Fetus as a Patient, Diagnosis and Therapy. Jerusalem, Isreal, May 26-31, 1985. 82. Graham J.M. Jr. and Ferm V.H.: Failure of folate supplementation to protect from neural tube defects induced experimentally by heat or alcohol. The 2nd International Symposium: The fetus as a Patient, Diagnosis and Therapy. Jerusalem, Isreal, May 26-31, 1985. 83. Graham J.M. Jr., Brown F.E. and Hall B.D.: Thumb polydactyly as part of the range of genetic expression for thenar hypoplasia. American Journal of Human Genetics 37:A132, 1985. 84. Rawnsley E.R., Simmons G.M., Graham J.M. Jr. and Crow H.C.: Prenatal diagnosis of X-linked hydrocephalus. American Journal of Human Genetics, 37:A135, 1985. 85. Edwards W.H., Graham, J.M. Jr., Horton W.A., Lachman R.S. and Rimoin D.L.: Otopalataldigital syndrome, type 2: Severe manifestations in a female infant. American Journal of Human Genetics, 37:A52, 1985. 86. Graham J.M. Jr., Edwards W.H., Horton W.A., Lachman R.S. and Rimoin D.L.: Otopalataldigital syndrome, type 2, versus atelosteogenesis: severe manifestations in a female infant. Proceedings of the Greenwood Genetic Center 5:112-113, 1986. 87. Graham J.M. Jr., Smith M., Fratkin J., Marin-Padilla M., Nordgren R., Saunders R., Cohen M.M., Klein R.Z.: Congenital hypothalamic hamartomas: A spectrum of developmental abnormality. Pediatric Research 20:338A, 1986. 88. Graham J.M. Jr., Rawnsley E.S., Nordgren R. and Fratkin J.: Autosomal dominant limb-girdle nuscular dystrophy with progressive cardiomyopathy: Report of a large family and delineation of natural history. Pediatric Research 20:337A, 1986. 89. Graham J.M. Jr., Charman C., Klein R.Z., Moeschler J.B.: New aspects of hyperthermia teratogenesis. Teratology 33:80C, 1986. 90. Park J.P., Graham J.M. Jr., Wurster-Hill D.H., Andrews P.A., Colley C., and Dossu J.R.: Partial trisomy 21 associated with microcephaly and parental double NOR. Karyogram 12:88, 1986. Printed January 28, 2015 - Page 44 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 75 of 130 PAGEID #: 42379 EXHIBIT 1 91. Graham J.M. Jr., Charman C., Hartman J., Moeschler J.B.: Malformation syndromes due to maternal hyperthermia. 7th International Congress of Human Genetics. Berlin, West Germany, September 22-27, 1986. 92. Graham J.M. Jr., Charman C., Hartman J., Rawnsley E. and Moeschler, J.B.: Malformation syndromes due to maternal hyperthermia. American Journal of Human Genetics, 39:A255, 1986. 93. Park J.P., Wurster-Hill D.H., Moeschler J.B., Graham J.M. Jr., and Charman C.E.: A de novo interstitial 4p deletion (pl6.1 p 15.2) associated with Wolf syndrome. American Journal of Human Genetics, 39:A128, 1986. 94. Moeschler J.B., Graham J.M. Jr., Rawnsley B.E., Park J.P. Wurster-Hill D.H., and Marin-Padilla M.: Neural tube defects in 13q- syndrome, American Journal of Human Genetics, 39:A72, 1986. 95. Rawnsley B.E., Charman C.E., Crow H. and Graham J.M. Jr.: Prenatal diagnosis of Jeune syndrome. American Journal of Human Genet. 39:A263, 1986. 96. Graham J.M. Jr., Rawnsley E.R., Nordgren R., Fratkin J.: Autosomal dominant limbgirdle muscular dystrophy with progressive cardiomyopathy: report of a large family and delineation of natural history, American Journal of Medical Genetics 25:720, 1986. 97. Graham J.M. Jr., Charman C.E., Moeschler J.B.: Neurogenic club feet associated with maternal hyperthermia. American Journal of Medical Genetics 25:739, 1986. 98. Graham J.M. Jr., Charman C.E., Hartman J., Rawnsley B.E. and Moeschler J.B.: Malformation syndromes due to maternal hyperthermia. Proceedings of the Greenwood Genetics Center, 6:115-116, 1987. 99. Moeschler J.B., Graham J.M. Jr., Rawnsley B.E., Park J.P., Wurster-Hill D.H. and Marin-Padilla M.: Neural tube defects in 13q- syndrome. Proceedings of the Greenwood Genetics Center, 6:140, 1987. 100. Volpe, M .V., Graham J.M. Jr., Miller F.S. III, Riskahl J.S., King R.A. and deMartinville B.: Linkage analysis in X-linked ocular albinism, Pediatric Research 21:295A, 1987. 101. Graham J.M. Jr., Charman C.E. and Chaisson R.: Postnatal Plagiocephaly: pathogenesis and therapy in 40 cases (1981-86), Pediatric Research 21:227A, 1987. 102. Moeschler J.B. Charman C.E., Berg S.Z., Graham J.M. Jr.: Rett syndrome: additional findings from 7 cases. Pediatric Research 21:229A, 1987. 103. Thomas IT, Cantu E.S., Frias J.L. Lafer C., Flannery D.B., Graham J.M. Jr.: Pigmentary abnormalities and chromosomal and genetic mosaicism and chimerism, Pediatric Research 21:294A, 1987. 104. Graham J.M. Jr.: Cranial asymmetry: 78 cases in 6 years (1981-1986), Teratology 35:50A, 1987. Printed January 28, 2015 - Page 45 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 76 of 130 PAGEID #: 42380 EXHIBIT 1 105. Park J.P. and Graham J.M. Jr., Wurster-Hill D.H.: Ring chromosome 12, Karyogram, 13(6):101, 1987. 106. Graham J.M. Jr., deMartinville B., Volpe M .A., Risdahl J.S., Rich S.S., Miller F.S. III and King R.A.: Clinical findings and linkage analysis in X-linked ocular albinism. American Journal of Human Genetics, 41:A64, 1987. 107. Iafolla A.K., Fratkin J.D., Spiegel P.K., Cohen M.M., Moeschler J.B. and Graham J.M. Jr.: Further delineation of the congenital hypothalamic hamartoblastoma syndrome. American Journal of Human Genetics, 41:A277, 1987. 108. Park J.P., Moeschler J.B., Graham J.M. Jr. and Wurster-Hill D.H.: Clinical and cytogenetic findings in 18q deletions: comparison of extreme distal del(l8)(pter q22.3) with more proximal deletions. American Journal of Human Genetics, 41:A137, 1987. 109. Charman C.E., Chaisson R., Donahue K.C. and Graham J.M. Jr.: Pathogenesis and treatment of plagiocephaly (1981-86). American Journal of Human Genetics, 41:A51, 1987. 110. Berg S.Z., Moeschler J.B., Charman C.E. and Graham J.M. Jr.: Genetics counseling issues for Rett syndrome families. American Journal of Human Genetics, 41:A193, 1987. 111. deMartinville B., Graham J.M. Jr., Volpe M.A., Risdahl J.S., Rich S.S., Miller F.S. III and King R.A.: Genetic analysis in X-linked ocular albinism. Presented at the Ninth International Workshop on Human Gene Mapping, Paris France, Sept. 611, 1987. 112. Donahue K.C., Charman C.E., Chaisson R., and Graham J.M. Jr.: Postnatal head deformation: Anthropological observations and applications to the treatment of postnatal plagiocephaly. Neural Crest and Craniofacial Disorders: (Eds. Opitz J.M ., Gorlin R.J., Reynolds J.F., and Spano L.M.) A.R. Liss Inc., New York, 1988. 113. Iafolla A.K., Fratkin J.D., Spiegel P.K., Cohen M.M., Moeschler J.B. and Graham J.M. Jr.: Further delineation of the congenital hypothalamic hamartoblastoma syndrome. Proceedings of the Greenwood Genetic Center, 7:188-189, 1988. 114. Graham J.M. Jr., deMartinville B., Volpe M .A., Risdahl J.S., Rich S.S., Pearson P.L., Miller F.S. III and King R.A.: Clinical findings and linkage analysis in X-linked ocular albinism. Proceedings of the Greenwood Genetic Center, 7:222-223, 1988. 115. Graham J.M. Jr., Charman C.E., Chaisson R. and Donahue K.C.: Postnatal head deformation: anthropological observations and applications to the treatment of postnatal plagiocephaly. Proceedings of the Greenwood Genetic Center, 7:156-159, 1988. 116. Moeschler J.B., Marin-Padilla M., Rawnsley E. and Graham J.M. Jr.: Pathogenesis of X-linked hydrocephalus: lessons from fetal neuropathology. Proceedings of the Greenwood Genetic Center 7:159-160, 1988. 117. Graham J.M. Jr., Charman C.E., Chaisson R. and Donahue K.C.: Pathogenesis and treatment of non-synostotic plagiocephaly. Clinical Research 36:218A, 1988. Printed January 28, 2015 - Page 46 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 77 of 130 PAGEID #: 42381 EXHIBIT 1 118. Graham J.M. Jr., deMartinville B., Volpe M .A., Risdahl J.S., Rish S.S., Pearson P.L., Miller F.S. and King R.A.: X-lined ocular albinism: clinical delineation and linkage analysis. Clinical Research 36:207A, 1988. 119. Moeschler J.B., Rawnsley E., Graham J.M. Jr. and Marin-Padilla M.: Pathogenesis of X-linked hydrocephalus: aqueductal stenosis is secondary to compression. Pediatric Research 23:269A, 1988. 120. Graham J.M. Jr., deMartinville B., Volpe M .A., Risdahl J.S., Rich S.S., Miller F.S. and King R.A.: Delineation of X-linked ocular albinism. Pediatric Research 23:267A, 1988. 121. Graham J.M. Jr., Edwards M .J., Lipson A., Uebster W. and Edwards M.J.: Gestational hyperthermia may cause Moebius syndrome. Pediatric Research 23:267A, 1988. 122. Graham J.M. Jr., Iafolla A.K., Fratkin J.D., Spiegel P.K. and Cohen M.M. Jr.: Delineation of congenital hypothalamic hamartoblastoma syndrome. Teratology 37:462, 1988. Presented at the Teratology Society Meeting, Palm Beach, Florida, June 10-15, 1988. 123. Graham J.M. Jr., Edwards M .J., Lipson A.H., Webster W.S. and Edwards M.J.: Gestational hyperthermia as a cause for Moebius syndrome. Teratology 37:461-442, 1988. Presented at the Teratology Society Meeting, Palm Beach, Florida, June 1015, 1988. 124. Graham J.M. Jr., Charman C.E., Chaisson R. and Donahue K.C.: Deformation as a cause and treatment for non-synostotic plagiocephaly. Teratology: The International Journal of Abnormal Development, 38(5~:521, 1988. Presented at the International Federation of Teratology Societies Meeting, Kyoto, Japan, July 1416, 1988. 125. Graham J.M. Jr., Edwards M .J., Lipson A.H., Webster W.S. and Edwards M.J.: Moebius syndrome caused by gestational hyperthermia. Teratology: The International Journal of Abnormal Development, 38t5):520, 1988. Presented at the International Federation of Teratology Societies Meeting, Kyoto, Japan, July 1416, 1988. 126. Graham J.M. Jr., Iafolla A.K., Fratkin J.D., Spiegel P.K. and Cohen M.M. Jr.: Congenital hypothalamic hamartoblastoma syndrome. Teratology: The International Journal of Abnormal Development, 38(5):520, 1988. Presented at the International Federation of Teratology Societies Meeting, Kyoto, Japan, July 14-16, 1988. 127. Berg S.Z., Furey P., and Graham J.M. Jr.: Paralysis of vertical gaze and hepatosplenomegaly as a phenotypic marker for Niemann-Pick disease, type C. American Journal of Human Genetics, 43:A39, 1988. Presented at the 1988 American Society of Human Genetics Meeting, New Orleans LA, Oct. 12-15, 1988. 128. Graham J.M. Jr., Morse R.P., Rockenmacher S., Lin A., Hall B.D., MacLeod P.J. and Pyeritz R.E.: Infantile Marfan Syndrome. American Journal of Human Genetics, 43:A51, 1988. Printed January 28, 2015 - Page 47 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 78 of 130 PAGEID #: 42382 EXHIBIT 1 129. Moeschler J.B., Shear T.R., Gibbs E.D., and Graham J.M. Jr.: Psychoeducational Aspects of Aarskog Syndrome. American Journal of Human Genetics, 43:A62, 1988. Presented at the 1988 American Society of Human Genetics Meeting, New Orleans, LA, Oct. 12-15, 1988. 130. Park J.P., Wurster-Hill D.H., Edwards M .J., and Graham J.M. Jr.: Diploid/polyploid mixoploidy in young adolescents confirmed by cytogenetic analysis of fibroblasts. American Journal of Human Genetics, 43:A63, 1988. 131. Edwards M .J., Moeschler J.B. and Graham J.M. Jr.: Clinical correlations with collagen biochemistry in osteogenesis imperfecta. American Journal of Human Genetics, 43:A82, 1988. 132. Neidich J.A., Nussbaum R.L., Packer R., Graham J.M. Jr., Donnenfeld A.E., Emanuel B.S. and Puck J.M.: Heterogeneity in clinical severity and molecular lesions in Aicardi syndrome. American Journal of Human Genetics, 43:A91, 1988. Presented at the 1988 American Society of Human Genetics Meeting, New Orleans, LA, October 1215, 1988. 133. Rawnsley E., Edwards M .J. and Graham J.M. Jr.: Cystic hygroma and lethal multiple pterygia. American Journal of Human Genetics, 43:A245, 1988. 134. Moeschler J.B., Edwards M .J., Graham J.M. Jr.: Lower extremity equivalent of the Poland anomaly. Pediatric Research, 78A, 1989. Presented at the Society for Pediatric Research Meeting, Washington D.C., May 3, 1989. 135. Graham J.M. Jr., Iafolla A.K., Lipson A.H., Webster W.S. and Edwards M.J.: Gestational hyperthermia as a possible cause for Moebius syndrome. Pediatric Research 25:76A 1989. Presented at the Society for Pediatric Research Meeting, Washington D.C., May 3, 1989. 136. Edwards M .J., Park J., Wurster-Hill D.H., Graham J.M. Jr.: Clinical features of diploid/polyploid mixoploidy in older individuals. Pediatric Research 25:76A, 1989. Presented at the Society for Pediatric Research Meeting, Washington D.C., May 3, 1989. 137. Borenstein T.C., Korenberg J.R., Platt L.D., Davos I., Gans S., Schreck R. and Graham J.M. Jr.: Congenital gastric teratoma in Beckwith-Wiedemann syndrome. Pediatric Research 25:75A, 1989. Presented at the Society for Pediatric Research Meeting, Washington D.C., May 3, 1989. 138. Graham J.M. Jr, Reynolds J.F. and Kelley R.I.: Cardio-Facio-Cutaneous (CFC) syndrome: Studies of peroxisomal and fatty acid metabolism. Proceedings of the Greenwood Genetic Center, 8:142-145, 1989. Presented at the IX David W. Smith Morphogenesis and Malformations Meeting, Oakland CA, Aug. 3-6, 1988. 139. Graham J.M. Jr, Morse R.P., Rochenmacher S., Lin A., Hall B.D., MacLeod P.J. and Pyeritz R.E.: Infantile Marfan syndrome. Proceedings of the Greenwood Genetic Center, 8:213-214, 1989. 140. Graham J.M. Jr, Edwards M .J., Lipson A.H., Webster W.S., Edwards M.J.: Gestational hyperthermia as a possible cause for Moebius syndrome. Proceedings ofthe Greenwood Genetic Center, 8:213, 1989. Printed January 28, 2015 - Page 48 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 79 of 130 PAGEID #: 42383 EXHIBIT 1 141. Graham J.M. Jr., Furrey P. and Berg S.Z.: Paralysis of vertical gaze and hepatosplenomegaly as a phenotypic marker for Niemann-Pick Disease, Type C. Proceedings of the Greenwood Genetic Center, 8:213, 1989. 142. Edwards M .J., Rawnsley E and Graham J.M. Jr.: Posterior nuchal systic hygroma and lethal multiple pterygia. Proceedings of the Greenwood Genetic Center, 8:156,1989. Presented at the IX David W. Smith Morphogenesis and Malformations Meeting, Oakland CA, Aug. 3-6, 1988. 143. Moeschler J.B., and Graham J.M. Jr.: Radial-renal-ocular syndromes: a phenotypic community. Proceedings of the Greenwood Genetic Center, 8:158-159, 1989. Presented at the IX David W. Smith Morphogenesis and Malformations Meeting, Oakland CA, Aug. 3-6, 1988. 144. Edwards M .J., Moeschler J.B. and Graham J.M. Jr.: Clinical and biochemical correlation in osteogenesis imperfecta. Proceedings of the Greenwood Genetic Center, 8:177, 1989. Presented at the IX David W. Smith Morphogenesis and Malformations Meeting, Oakland CA, Aug. 3-6, 1988. 145. Lin A.E., Morter G. and Graham J.M. Jr.: CNS malformations in the CHARGE association. Proceedings of the Greenwood Genetic Center, 8:202, 1989. Presented at the IX David W. Smith Morphogenesis and Malformations Meeting, Oakland CA, Aug. 3-6, 1988. 146. Graham J.M. Jr.: New syndrome of hypoplastic 1st and 2nd digital rays, microcephaly, and diabetes in siblings born to consanguineous parents. Proceedings of the Greenwood Genetics Center, in press, 1990. Presented at the X David W. Smith Morphogenesis and Malformations Meeting, Madrid, Spain, May 23-27, 1989. 147. Korenberg J.R., Barker D., Fain P., Graham J.M. Jr., Pribyl T., Pulst S.M.: Achondroplasia is not tightly linked to the locus for neurofibromatosis 1. Presented at the Tenth International Workshop on Human Gene Mapping. New Haven, CT, June 10-17, 1989. 148. Graham J.M. Jr.: New syndrome of hypoplastic 1st and 2nd digital rays, microcephaly, and diabetes in siblings born to consanguineous parents. Presented at the March of Dimes Clinical Genetics Conference, Boston MA, July 9-12, 1989. 149. Neidich J.A., Emanuel B.S., Graham J.M. Jr., Nussbaum R.L., Packer R.J. and Puck J.M.: X inactivation and molecular mapping in Aicardi Syndrome. Presented at the March of Dimes Clinical Genetics Conference, Boston MA, July 9-12, 1989. 150. Cooley W.C., Graham E.S., Moeschler J.B., Graham J.M. Jr.: Reactions of mothers and professionals to a film of parents of persons with Down syndrome. Developmental Medicine and Child Neurology, Presented at the American Academy of Cerebral Palsy and Developmental Medicine Meeting, San Francisco, CA, October 26, 1989. 151. Graham J.M. Jr.: New syndrome of type A2 brachydactyly, microcephaly, and diabetes in siblings born to consanguineous parents. American Journal of Human Genetics, 45(4):A76, 1989. Presented at the American Society of Human Genetics Meeting, Baltimore MD, November 11-15, 1989. Printed January 28, 2015 - Page 49 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 80 of 130 PAGEID #: 42384 EXHIBIT 1 152. Cantrell M .A., Simpson E., Bicknell J.N., Pagon R.A., Walker D.C., Thuline H.C., Graham J.M. Jr.: Absence of H-Y antigen expression in a patient with deletion of the long arm of the Y chromosome and isolation of new DNA probes for region 6 of the Y chromosome. American Journal of Human Genetics, 45(4):A134, 1989. Presented at the American Society of Human Genetics Meeting, Baltimore MD, November 11-15, 1989. 153. Francomano C.A., Finkelstein J.E., Yamada Y ., Pyeritz R.E., Graham J.M. Jr.: Analysis of the chondroitin sulfate proteoglycan core protein (CSPGCP) gene in achondroplasia and pseudoachondroplasia. American Journal of Human Genetics, 45(4):A140, 1989. Presented at the American Society of Human Genetics Meeting, Baltimore MD, November 11-15, 1989. 154. Pribyl T., Korenberg J.R., Barker D., Fain P., Ren M., Graham J.M. Jr., Pulst S.M.: The gene for achondroplasia is not tightly linked to the locus for neurofibromatosis. American Journal of Human Genetics, 45(4):A157, 1989. Presented at the American Society of Human Genetics Meeting, Baltimore MD, November 11-15, 1989. 155. Richardson, M., Christian C.L., Platt L.D., Santulli T., DePond W., Peckowitz S.H., Graham J.M. Jr.: Lethal cardiac anomalies in fetal Turner syndrome. Clinical Research, 38(1):188A, 1990. Presented at the Western Society of Pediatric Research Meeting, Carmel, CA, February 6 9, 1990. 156. Edwards M .J., Moeschler J.B., Fahy M .J., Hall J.G., Graham J.M. Jr.: History of gestational hyperthermia in two patients with amyoplasia. Clinical Research, 38(1):186A, 1990. 157. Edwards M .J., Rawnsley E., Graham J.M. Jr.: Cystic hygroma and lethal multiple pterygia in a fetus. Clinical Research, 38(1):186A, 1990. Presented at the Western Society of Pediatric Research Meeting, Carmel, CA, February 6-9, 1990. 158. Graham J.M. Jr., Moeschler J.B., Cooley W.C.: Reactions of mothers and professionals to a film of parents of persons with Down syndrome. Clinical Research, 38(1):186A, 1990. 159. Graham J.M. Jr.: New syndrome of type A2 brachydactyly, microcephaly and diabetes in siblings born to consanguineous parents. Clinical Research, 38(1):186A, 1990. 160. Smith A.C.M , Graham J.M. Jr., Hall J.G.: Congenital contractures, brain structural anomalies, cardiac anomalies and renal anomalies. Clinical Research, 38(1):188A, 1990. Presented at the Western Society of Pediatric Research Meeting, Carmel, CA, February 6-9, 1990. 161. Cooley W.C., Graham E.S., Moeschler J.B., Graham J.M. Jr.: Reactions of mothers and medical professionals to a film of parents of persons with Down syndrome. Presented at the Ambulatory Pediatric Society, Region I Annual Meeting, Farmington, CT, February 9, 1990. 162. Edwards M .J., Moeschler J.B., Fahy M .J., Hall J.G., Graham J.M. Jr.: History of gestational hyperthermia in two patients with amyoplasia. Pediatric Research, 27(4):68A, 1990. Presented at the Society for Pediatric Research Meeting, Anaheim, CA, May 7, 1990. 163. Christian C.L., Richardson M., Platt L.D., Santulli T., DePond W., Peckowitz S.H., Graham J.M. Jr.: Turner syndrome and hypoplastic left heart. Pediatric Research, 27(4):67A, 1990. Printed January 28, 2015 - Page 50 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 81 of 130 PAGEID #: 42385 EXHIBIT 1 164. Falik-Borenstein T.C., Graham J.M. Jr., Schreck R.R.: Chimerism versus mosaicism in CVS. Pediatric Research, 27(4):68A, 1990. Presented at the Society for Pediatric Research Meeting, Anaheim, CA, May 7, 1990. 165. Moeschler, J.B., Edwards, M .J., and Graham, J.M. Jr.: Lower extremity equivalent of the Poland anomaly. Teratology 41(5):579, 1990. Presented at the Teratology Society Meeting, Victoria, B.C., June 6, 1990. 166. Edwards, M .J., Moeschler, J.B., Fahy, M., Hall, J.G ., and Graham, J.M. Jr.: History of gestational hyperthermia in two patients with amyoplasia. Teratology 41(5):552, 1990. Presented at the Teratology Society Meeting, Victoria, B.C., June 6, 1990. 167. Tick, D.B., Greenberg, F. and Graham, J.M. Jr.: The pattern and form of human somatic structural ectopy. Teratology 41(5):596, 1990. Presented at the Teratology Society Meeting, Victoria, B.C., June 6, 1990. 168. Graham, J.M. Jr.: New Syndrome of hypoplastic 1st and 2nd digital rays, microcephaly, and diabetes in siblings born to consanguinous parents. Proceedings of the Greenwood Genetics Center 9:1103-104, 1990. Presented at the X David W. Smith Workshop on Malformations and Morphogenesis, Madrid, Spain, May 23-29, 1989. 169. Graham J.M. Jr., Edwards Matthew J., Iafolla, A.K., Moeschler J.B., Edwards Marshall J.: Sporadic patterns of anomalies due to maternal hyperthermia: Moebius syndrome and amyoplasia. American Journal of Human Genetics, 47(3):458, 1990 170. Christian C.L., Nagel R.A., and Graham J.M. Jr.: Marinesco-Sjogren syndrome associated with decreased growth hormone levels. American Journal of Human Genetics, 47(3):A51, 1990. 171. Klein J., Hixon H.E.C., Graham J.M. Jr.: Multidisciplinary involvement in the evaluation of aborted fetuses and stillborns: case reports and literature review. American Journal of Human Genetics, 47(3):A279, 1990. 172. Toriello H.V., Moeschler J.M ., Graham J.M. Jr., Higgins J.V.: Syndromes with renal, radial and ocular defects: A phenotypic community. American Journal of Human Genetics, 47(3):A80, 1990. 173. Graham, J.M. Jr., Rimoin, D.L., Tolo, V., Jones, M.C. and Marsh, J.L.,: Surgical treatments for congenital anomalies. American Journal of Human Genetics, 47(3):21, 1990. Presented at the American Society of Human Genetics Meeting, Cincinnatti OH, October 16-21, 1990. 174. Graham, J.M. Jr. Edwards M .J., Iafolla, A.K., and Moeschler, J.B.: Sporadic patterns of anomalies due to maternal hyperthermia: Moebius syndrome and amyoplasia. Proceedings of the Greenwood Genetics Center, 10:106, 1991. Presented at the X I David U. Smith Workshop on Malformations and Morphogenesis, Lexington, K Y, August 5-8, 1990. Printed January 28, 2015 - Page 51 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 82 of 130 PAGEID #: 42386 EXHIBIT 1 175. Christian C.L., Lachman R.S., Aylesworth A.S., Fujimoto A., Gorlin R.J., Lipson M.H. and Graham J.M. Jr.: Radiological findings in Hallermann-Streiff syndrome: report of five cases and a review of the literature. Proceedings of the Greenwood Genetic Center, 10:123. XII David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead, CA, September 27October 1, 1991. 176. Graham, J.M. Jr., Edwards, M .J., Iafolla, A.K., Moeschler, J.B.: Sporadic patterns of anomalies due to maternal hyperthermia: Moebius syndrome and amyoplasia. Presented at the 4th Manchester Birth Defects Conference, Manchester, England, October 2-5, 1990 177. Sharony R., Garber A., Schreck R., Platt L., Viskochil D., Graham J.M. Jr.: Radial ray reduction defects as part of the valproic acid embryopathy spectrum. Clinical Research, 39(1):65A, 1991. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, February 6-9, 1991. 178. Christian C.L., Fleisher D.R., Feldman E.J., Pepkowitz S.H., Iafolla A.K., DiLiberti J.J., Graham J.M. Jr.: Lipid storage myopathy associated with Ruvalcaba-Myhre-Smith syndrome: Treatment with carnitine. Clinical Research, 39(1):64A, 1991. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, February 6-9, 1991. 179. Curry C.J.R., Micek M., Yu C., Golbus M., Graham J.M. Jr.: Prenatal diagnosis of trisomy 12 mosaicism. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, February 6-9, 1991. Clinical Research, 39(1):65A, 1991. 180. Klein J., Platt L., Tick D., Carlson D., Pepkowitz S., Graham J.M. Jr.: Fraser syndrome: Prenatal and postnatal diagnosis. Clinical Research, 39(1):134A, 1991. 181. Falik-Borenstein T.C., Graham J.M. Jr., Klein J., Schreck R.R.: Trisomy 8 mosaicism in CVS: postnatal confirmation studies and pregnancy outcome. Pediatric Research, 29(4):69A, 1991. 182. Sharony R., Garber A., Schreck R., Platt L.D., Buehler B.A., Graham J.M. Jr.: Valproate exposure during pregnancy causing radial ray reduction defects. Pediatric Research, 29(4):71A, 1991. 183. Christian C.L, Fleischer D.R., Feldman E.J., Pepkowitz S.H., Iafolla A.K., DiLiberti J.H., Graham J.M. Jr.: Carnitine deficiency and lipid storage myopathy associated with RuvalcabaMyhre-Smith syndrome. Pediatric Research, 29(4):68A, 1991. Presented at the The Society for Pediatric Research Meeting, New Orleans, LA, April 29-May 2, 1991. 184. Graham J.M. Jr., Sharony R., Garber A., Schreck R., Platt L.D., Buehler B.A.: Preaxial ray reduction defects valproate exposure during pregnancy. Teratology, 43(5):441, 1991. Presented at the Teratology Society Meeting, Boca Raton, FL, June 25, 1991. 185. Christian C.L., Pressman B.D., Schreck R., Roulston D., Graham J.M. Jr.: Progression of cranial imaging findings in the acrocallosal syndrome. Presented at the March of Dimes Clinical Genetics Conference, Vancouver, B.C. Canada, July 7-10, 1991. Printed January 28, 2015 - Page 52 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 83 of 130 PAGEID #: 42387 EXHIBIT 1 186. Graham J.M. Jr.: Familial progressive cerebral calcification, microcephaly, spastic quadraparesis and failure of developmental progression. Presented at the March of Dimes Clinical Genetics Conference, Vancouver, B.C. Canada, July 7-10, 1991 . 187. Sharony R., Pepkowitz S., Hixon H., Graham J.M. Jr.: Diprosopus - A pregastrulation defect involving the head, neural tube, heart and diaphragm. Proceedings of the Greenwood Genetic Center, 11:80-81, 1992. Presented at the XII David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead, CA, September 27-October 1, 1991. 188. Perez-Aytes A., Carey J.C., Hoyme E.H., Graham J.M. Jr., Aleck K.: Urethral obstruction sequence, lower limb reduction defects, and the vascular disruption hypothesis. Proceedings of the Greenwood Genetic Center, 11:71-72, 1992. Presented at the XII David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead, CA, September 27-October 1, 1991. 189. Moeschler J.B., Graham J.M. Jr.: "Mild" Brachmann-deLange syndrome: phenotypic and developmental characteristics of mildly affected individuals. Proceedings of the Greenwood Genetic Center, 11:113-114, 1992. Presented at the XII David R. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead, CA, September 27-October 1, 1991. 190. Braddock S., Lachman R., Charman C., Carey J.C ., Ireland M., Graham J.M. Jr.: Radiological features in Brachmann-deLange syndrome. Proceedings of the Greenwood Genetic Center, 11:130, 1992. Presented at the XII David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead, CA, September 27-October 1, 1991. 191. Christian C.L., Schreck R., Neufeld N., Graham J.M. Jr.: Mosaic trisomy 13: phenotypic presentations and clinical implications for prenatal diagnosis. Proceedings of the Greenwood Genetics Center, 11:163-164, 1992. Presented at the XII David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead, CA, September 27-October 1, 1991. 192. Sharony R., Pepkowitz S., Hixon H., Graham J.M. Jr.: Diprosopus - A pregastrulation defect involving the head, neural tube, heart and diaphragm. Presented at the Second International Workshop on Fetal Genetic Pathology, Big Sky, Montana, October 12-16, 1991. 193. Sharony R., Hixon H., Pepkowitz S., Carlson D., Platt L., Graham J.M. Jr.: Experience with a fetal dysmorphology/pathology service in an academic medical center. Presented at the Second International Workshop on Fetal Genetic Pathology, Big Sky, Montana, October 12-16, 1991. 194. Wagstaff J., Knoll, J.H.M., Fleming J., Kirkness E.F., Martin-Gallardo A., Greenberg F., Graham J.M. Jr., Menninger J., Ward D., Venter J.C ., Lalande M. Localization of the GABAA receptor B3 subunit gene (GABRB3) to the Angelman/Prader-Willi region of human chromosome 15. American Journal of Human Genetics, 49(4):422, 1991. Presented at 8th International Congress of Human Genetics, Washington, DC. October 6-11, 1991. 195. Knoll J.H.M., Wagstaff J., Glatt K., Graham J.M. Jr., Greenberg F., Horsthemke B., Lalande M. Molecular analysis of distal 15qllql3: A difference between Angelman and Prader-Willi syndromes. American Journal of Human Genetics, 49(4):18, 1991. Presented at 8th International Congress of Human Genetics, Washington, DC. October 6-11, 1991. Printed January 28, 2015 - Page 53 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 84 of 130 PAGEID #: 42388 EXHIBIT 1 196. Carlson D., Graham J.M. Jr., Platt L.D., Pepkowitz S.H., Klein J. Early Prenatal Diagnosis of Fraser Syndrome. American Journal of Human Genetics, 49(4):129, 1991. Presented at 8th International Congress of Human Genetics, Washington, DC. October 6-11, 1991. 197. Garber A., Klein J., Carlson D., Platt L., Graham J.M. Jr.: Natural history of recurrent, nonsyndromal posterior nuchal cystic hygroma. American Journal of Human Genetics, 49(4):138, 1991. Presented at 8th International Congress of Human Genetics, Washington, DC. October 6 11, 1991. 198. Falik-Borenstein T., Graham J.M. Jr., Platt L., Schreck R.: Chromosomal mosaicism in cvs: fetal development and pregnancy outcome, a two years follow-up. American Journal of Human Genetics, 49(4):173, 1991. Presented at 8th International Congress of Human Genetics, Washington, DC. October 6-11, 1991. 199. Bohlman M .C., Edwards M .J., Graham J.M. Jr., Fischel-Ghodsian N.: Deletion in blood mitochondrial DNA in Kearns-Sayre syndrome. American Journal of Human Genetics, 49(4):187, 1991. Presented at the 8th International Congress of Human Genetics, Washington, D C. October 6-11, 1991. 200. Klein J., Schreck R., Platt L.D., Borenstein T., Graham J.M. Jr.: CVS mosaicism for trisomy 8 and genetic counseling. American Journal of Human Genetics, 49(4):221, 1991. Presented at the 8th International Congress of Human Genetics, Washington, DC. October 6-11, 1991. 201. Christian C.L., Schreck R., Neufeld N., Graham J.M. Jr.: Mosaic trisomy 13: phenotypic presentations. American Journal of Human Genetics, 49(4):259, 1991. Presented at the 8th International Congress of Human Genetics, Washington, DC. October 6-11, 1991. 202. Coons G., Klein J., Schreck R., Pepkowitz S., Graham J.M. Jr.: Flow cytometric diagnosis of clinically suspected triploidy. American Journal of Human Genetics, 49(4):259, 1991. Presented at the 8th International Congress of Human Genetics, Washington, DC. October 6-11, 1991. 203. Roulston D., Altherr M., Wasmuth J.J., Christian C., Graham J.M. Jr., Schreck R.R.: Confirmation of a suspected deletion of 4pl6 by fluorescent in situ hybridization (FISH) with a cosmid probe. American Journal of Human Genetics, 49(4):274, 1991. Presented at the 8th International Congress of Human Genetics, Washington, DC. October 6-11, 1991. 204. Braddock S.R., Lachman R.S., Graham J.M. Jr.: Radiology of mild DeLange syndrome. Clinical Research 40(1):57A, 1992. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, February 5-8, 1992. 205. Bacino C.A, Platt L.D., Carlson D., Pepkowitz S., Garber A., Graham J.M. Jr.: Prenatal detection and natural history of the Neu-Laxova syndrome. Pediatric Research, 31(4):68A, 1992. Presented at the Society for Pediatric Research Meeting, Baltimore, MD, May 4-7, 1992. 206. Braddock S.R., Charman C.E., Clarren S.K., Graham J.M. Jr.: Distinguishing characteristics and long term outcomes associated with malformational vs. deformational craniosynostosis. Teratology, 45:462, 1992. Presented at the Teratology Society Meeting, Boca Raton, FL, June 28-July 2, 1992. Printed January 28, 2015 - Page 54 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 85 of 130 PAGEID #: 42389 EXHIBIT 1 207. Garber A.P., Carlson D.E., Klein J., Schreck R., Braddock S.R., [Baham J.M. Jr.: Clinical findings in mosaic trisomy 16. Teratology, 45:508, 1992. Presented at the Teratology Society Meeting, Boca Raton, FL, June 28-July 2, 1992. 208. Hsu W.T., Carlson D.E., Klein J., Fischel-Ghodsian N., Graham J.M. Jr., Schreck R.: Prenatal detection of mosaic trisomy 16 associated with neonatal lethal phenotype. Presented at March of Dimes Clinical Genetics Conference, Stanford University, Palo Alto, CA, July 12-15, 1992. 209. Weng E.Y., Moeschler J.B., Graham J.M. Jr.: Longitudinal follow-up in 14 probands with Beckwith-Wiedemann syndrome. Proceedings of the Greenwood Genetics 12:59-60, 1993. Presented at the XIII David W. Smith Workshop on Malformations and Morphogenesis, Wake Forest University, Winston-Salem, NC, August 5-9, 1992. 210. Wilcox W.R., Graham J.M. Jr.: The acrocallosal syndrome: Report of 4 cases, review of the literature, and proposed diagnostic criteria. Proceedings of the Greenwood Genetics 12:56, 1993. Presented at the XIII David W. Smith Workshop on Malformations and Morphogenesis, Wake Forest University, Winston-Salem, NC, August 5-9, 1992. 211. Braddock S.R., Graham J.M. Jr.: Ventruto syndrome: Report of a second family. Proceedings of the Greenwood Genetics 12:106, 1993. Presented at the XIII David W. Smith Workshop on Malformations and Morphogenesis, Wake Forest University, Winston-Salem, NC, August 5-9, 1992. 212. Graham J.M. Jr., Braddock S.R.: Distinguishing characteristics and long term outcomes associated with malformational vs. deformational craniosynostosis. Presented at the 5th Manchester Birth Defects Conference, Manchester, United Kingdom, October 13-16, 1992. 213. Weng E.Y., Moeschler J.B., Graham J.M. Jr.: Longitudinal follow-up in 14 probands with Beckwith-Wiedemann syndrome. American Journal of Human Genetics, 51(4):A311, 1992. 214. Sharony R., Carlson D.E., Graham J.M. Jr., Platt L.D.: Prenatal diagnosis of conjoined twins: associated sonographic anomalies. American Journal of Human Genetics, 51(4):A414, 1992. 215. Weng E.Y., Moeschler J.B., Graham J.M. Jr.: Longitudinal follow-up in 14 probands with Beckwith-Wiedemann syndrome. Clinical Research, 41(1):70A, 1993. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, February 17-20, 1993. 216. Rabinowitz YS, Wilcox W, Shorr N, Enzer Y, and Graham JM Jr.: Fraser cryptopthalmos syndrome (FCS) with visual potential following eyelid and forniceal reconstruction. Investigative Opthalmology and Visual Science, 1993. Presented at the Association for Research and Vision in Ophthalmology, Sarasota, FL, May 27, 1993. 217. Rabinowitz YS, Wilcox W, Shorr N, Enzer Y, and Graham JM Jr.: Fraser cryptopthalmos syndrome (FCS) with visual potential following eyelid and forniceal reconstruction. Presented at the International Conference on Cornea and Eye Banking, Jerusalem, Israel, June 20-24, 1993. Printed January 28, 2015 - Page 55 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 86 of 130 PAGEID #: 42390 EXHIBIT 1 218. Garber, A., Schreck R., Oeztas S., Carlson D.E., Fischel-Ghodsian N., Hsu W-T, Graham J.M. Jr.: Uniparental disomy for chromosome 16 in a fetus. Presented at the Seventh International Clinical Genetics Seminar on Dysmorphology and Genetics of Cardiovascular Disorders, Pythagorion, Samos, Greece, May 27-June 1, 1993. 219. Graham J.M. Jr., Edwards M.J.: Diploid polyploid mixoploidy in young adults. Teratology 47(5):56, 1993. Presented at the Teratology Society Meeting, Tucson, AZ, June 26-July 1, 1993. 220. Garber A., Schreck R., Oeztas S., Carlson D., Fischel-Ghodsian N., Hsu W., Graham J.M. Jr.: Analysis of prenatally-detected mosaic trisomy 16. Teratology 47(5):57, 1993. Presented at the Teratology Society Meeting, Tucson, AZ, June 26July 1, 1993. 221. Graham J.M. Jr., Skovby F., Cohen M.M.: Spinal cord compromise in Proteus syndrome. Proceedings of the Greenwood Genetics 13:130, 1994. Presented at the X IV David W. Smith Workshop on Malformations and Morphogenesis, Mont-Tremblant, Quebec, Canada, August 12 17, 1993. 222. Bacino C.A., Schreck R., Pepkowitz S., Graham J.M. Jr.: Non-mosaic trisomy 22 surviving through late gestation: delineation of the clinical phenotype. Proceedings of the Greenwood Genetics 13:119, 1994. Presented at the XIV David W. Smith Workshop on Malformations and Morphogenesis, Mont-Tremblant, Quebec, Canada, August 12-17, 1993. 223. Graham J.M. Jr., Prowse M., Hixon H., Johnson C.: Urorectal septal malformation sequence and extrophy of the cloaca malformation sequence: a spectrum of problems in cloacal septation. Proceedings of the Greenwood Genetics 13:74, 1994. Presented at the X IV David W. Smith Workshop on Malformations and Morphogenesis, Mont-Tremblant, Quebec, Canada, August 12 17, 1993. 224. Hsu W-T., Garber A., Carlson D., Fischel-Ghodsian N., Graham J.M. Jr., Linn S., Wheeler M., Oztas, Schreck R.: Prenatal detected trisomy 16 in two phenotypically abnormal newborns. American Journal of Human Genetics, 53(3):A1419, 1993. Presented at the 43rd American Society of Human Genetics Meeting, New Orleans, LA, October 5-9, 1993. 225. Graham J.M. Jr., Skovby F., Cohen M.M.: Spinal cord compromise in Proteus syndrome. American Journal of Human Genetics, 53(3):A443, 1993. Presented at the 43rd American Society of Human Genetics Meeting, New Orleans, LA, October 5-9, 1993. 226. Bacino C.A., Graham J.M. Jr., Fischel-Ghodsian N., Hsu W.T., Schreck, R. Nonmosaic trisomy 22: a lethal trisomy surviving to late gestation. American Journal of Human Genetics, 53(3):A1380, 1993. Presented at the 43rd American Society of Human Genetics Meeting, New Orleans, LA, October 5-9, 1993. 227. Rabinowitz YS, Wilcox W, Shorr N, Enzer Y, and Graham JM Jr.: Fraser cryptopthalmos syndrome (FCS) with visual potential following eyelid and forniceal reconstruction. Presented at the American Academy of Ophthalmology, Chicago, IL, November 8-15, 1993. Printed January 28, 2015 - Page 56 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 87 of 130 PAGEID #: 42391 EXHIBIT 1 228. Ming JE, Stiehm ER, Graham JM Jr.: Immunodeficiency as a component of genetic syndromes. Pediatric Research, 35(4):92A, 1994. Presented at the American Pediatric Society-Society for Pediatric Research Meeting, Seattle, WA, May 2-5, 1994. 229. Ming JE, Stiehm ER, Graham JM Jr.: Immunodeficiency is a component of genetic syndromes. Presented at the Workshop on Primary and Acquired Immunodeficiencies, Orvieto, Italy, June 18-21, 1994. 230. Ming JE, Stiehm ER, Graham JM Jr.: Immunodeficiency as a component of genetic syndromes. Teratology 49(5):405, 1994. Presented at the Teratology Society Meeting, Las Croabas, Puerto, June 25-30, 1994. 231. Mortier, GR, Wilkin DJ, Stern H, De Paepe A, Falk RE, Shohat M, Schwartz CE, Johnson CL, Jones MC, Jones KL, Graham JM Jr, Rimoin DL, Cohn DH.: Clinical features in Stickler syndrome families linked and unlinked to the type II collagen gene. Proceedings of the Greenwood Genetics Center,14:48, 1995. Presented at the X V David W. Smith Workshop on Malformations and Morphogenesis, Tampa, Florida, August 4-9, 1994. 232. Moeschler JB, Guttmacher AE, Graham JM Jr.: Blepharophimosis-cleft palatehypogonadismgrowth and mental retardation: a new multiple congenital anomaly/mental retardation syndrome in brothers. Proceedings of the Greenwood Genetics Center, 14:85, 1995. Presented at the X V David W. Smith Workshop on Malformations and Morphogenesis, Tampa, Florida, August 4-9, 1994. 233. Bhatt S, Wilcox WR, Dobyns WB, Pressman BD, Graham JM Jr.: Recurrent frontal cortical dysplasia - A new neuronal migration disorder. Proceedings of the Greenwood Genetics Center, 14:70, 1995. Presented at the X V David W. Smith Workshop on Malformations and Morphogenesis, Tampa, Florida, August 4-9, 1994. 234. Graham JM Jr., Hixon H, Bacino CA, Daack-Hirsch S, Stadler S, Murray JC: Autosomal dominant transmission of a Goldenhar-like syndrome: description of a family and report of a sporadic case with de novo 4pl6; 8q24.11 translocation. Proceedings of the Greenwood Genetics Center, 14:41, 1995. Presented at the X V David W. Smith Workshop on Malformations and Morphogenesis, Tampa, Florida, August 4-9, 1994. 235. Bhatt S, Dobyns WB, Pressman BD, Graham JM Jr: Apparent X-linked pachygyria/lissencephaly with agenesis of the corpus callosum. American Journal of Human Genetics 55(3):A78, 1994. Presented at the American Society of Human Genetics Meeting, Montreal, Quebec, October 18-22, 1994. 236. Ming JE, Stiehm ER, Graham JM Jr: Immunodeficiency as a component of recognizable syndromes. American Journal of Human Genetics 55(3):A88, 1994. Presented at the American Society of Human Genetics Meeting, Montreal, Quebec, October 18-22, 1994. Printed January 28, 2015 - Page 57 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 88 of 130 PAGEID #: 42392 EXHIBIT 1 237. Graham JM Jr., Hixon H, Bacino CA, Daack-Hirsch S, Stadler S, Murray JC: Autosomal dominant transmission of a Goldenhar-like syndrome: Description of a family and report of a sporadic case with a de novo 4pl6; 8q24.11 translocation. American Journal of Human Genetics 55(3):A107, 1994. Presented at the American Society of Human Genetics Meeting, Montreal, Quebec, October 18-22, 1994. 238. Graham JM Jr., Biesecker LG: Linking, lumping and splitting Pallister-Hall syndrome. Presented at the National Biomedical Research Day, Cedars-Sinai Medical Center, Los Angeles, California, October 21, 1994. 239. Graham JM Jr., Hixon H., Bacino CA, Daack-Hirsch S., Stadler S., Murray JC: Autosomal dominant transmission of a Goldenhar-like syndrome with linkage to the branchio-oto-renal syndrome locus at 8ql3.3. Presented at the National Biomedical Research Day, Cedars-Sinai Medical Center, Los Angeles, California, October 21, 1994. 240. Graham JM Jr., Hixon H., Bacino CA, Daack-Hirsch S., Stadler S., Murray JC: Autosomal dominant transmission of a Goldenhar-like syndrome with linkage to the branchio-oto-renal syndrome locus at 8ql3.3. Presented at the 6th Manchester Birth Defects Conference, Manchester, United Kingdom, November 1-4, 1994. 241. Graham JM Jr., Biesecker LG: Lumping and splitting clinical entities within the Pallister-Hall syndrome. Presented at the 6th Manchester Birth Defects Conference, Manchester, United Kingdom, November 1-4, 1994. 242. Graham JM Jr., Hixon H., Bacino CA, Daack-Hirsch S., Stadler S., Murray JC: Autosomal dominant transmission of a Goldenhar-like syndrome with linkage to the branchio-oto-renal syndrome locus at 8ql3.3. Clinical Research, 43:137A,1995. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, February 9-11, 1995. 243. Graham JM Jr., Biesecker LG: Lumping and splitting clinical entities within the Pallister-Hall syndrome. Clinical Research, 43:136A, 1995. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, February 9-11, 1995. 244. Bhatt S, Wilcox WR, Dobyns WB, Pressman BD, Graham JM Jr.: Recurrent frontal cortical dysplasia - A new neuronal migration disorder. Clinical Research, 43:152A, 1995. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, February 9-11, 1995. 245. Graham JM Jr., Biesecker LG: Genetics of Pallister-Hall syndrome. Presented at the 26th Annual March of Dimes Clinical Genetics Conference and the American College of Medical Genetics 2nd Annual Meeting, Los Angeles, CA, March 6-9, 1995. 246. Kim J, Hall BD, Goodfellow PJ, Graham JM Jr: Report of two families with X-linked cleft palate/ankyloglossia: description of clinical findings. Presented at the 26th Annual March of Dimes Clinical Genetics Conference and the American College of Medical Genetics 2nd Annual Meeting, Los Angeles, CA, March 6-9, 1995. Printed January 28, 2015 - Page 58 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 89 of 130 PAGEID #: 42393 EXHIBIT 1 247. Hixon HH, Krakow D, Pepkowitz SH, Graham JM Jr: Intrauterine fetal demise evaluated through a Fetal Dysmorphology/Pathology Service. Presented at the 26th Annual March of Dimes Clinical Genetics Conference and the American College of Medical Genetics 2nd Annual Meeting, Los Angeles, CA, March 6-9,1995. 248. Graham JM Jr., Biesecker LG: Lumping and splitting within the Pallister-Hall syndrome - A lesson in human pathology. Invited Presentation at the 6th Biennial Congress of the Human Genetics Society, Club Mykonos, Langebaan, South Africa, March 26-29, 1995. 249. Graham JM Jr., Hixon H, Bacino CA, Daack-Hirsch S, Stadler S, Murray JC: Autosomal dominant transmission of a Goldenhar-like syndrome with linkage to the branchio-oto-renal syndrome locus at 8ql3.3. Presented at the 6th Biennial Congress of the Human Genetics Society, Club Mykonos, Langebaan, South Africa, March 26-29, 1995. 250. Bhatt S, Wilcox WR, Dobyns WB, Pressman BD, Graham JM Jr.: Recurrent frontal cortical dysplasia - A new neuronal migration disorder. Presented at the 6th Biennial Congress of the South African Human Genetics Society, Club Mykonos, Langebaan, South Africa, March 26-29, 1995. 251. Graham JM Jr., Biesecker LG: Linking, lumping and splitting Pallister-Hall syndrome. Presented at the IV International Fetal Genetic Pathology Workshop, Kruger National Park, South Africa, March 31-April 2, 1995. 252. Graham JM Jr.: Status of the human gene map for craniofacial malformation syndromes. Invited Presentation at the IV International Fetal Genetic Pathology Workshop, Kruger National Park, South Africa, March 31-April 2, 1995. 253. Graham JM Jr., Biesecker LG: The Genetics of Pallister-Hall syndrome. Pediatric Research 37:82A, 1995. Presented at the American Pediatric Society and Society for Pediatric Research Annual Meeting, San Diego, CA, May 7-11, 1995. 254. Graham JM Jr., Hixon H, Bacino CA, Daack-Hirsch S, Stadler S, Murray JC: Autosomal dominant transmission of a Goldenhar-like syndrome with linkage to the branchio-oto-renal syndrome locus at 8ql3.3. Pediatric Research 37:83A, 1995. Presented at the American Pediatric Society and Society for Pediatric Research Annual Meeting, San Diego, CA, May 7-11, 1995. 255. Kim J, Hall BD, Goodfellow PJ, Graham JM Jr: Report of two families with X-linked cleft palate/ankylogossia: description of clinical findings. Pediatric Research 37:83A, 1995. Presented at the American Pediatric Society and Society for Pediatric Research Annual Meeting, San Diego, CA, May 7-11, 1995. 256. Wilcox WR, Graham JM Jr, Reinker K, Hsia YE, Rimoin DL: Marinesco-Sjogren syndrome is a lysosomal lipid storage disorder and is not corrected in vitro by co-culture with control cells. Pediatric Research 37:155A, 1995. Presented at the American Pediatric Society and Society for Pediatric Research Annual Meeting, San Diego, CA, May 7-11, 1995. Printed January 28, 2015 - Page 59 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 90 of 130 PAGEID #: 42394 EXHIBIT 1 257. Graham JM Jr, Biesecker LG: The genetics of Pallister-Hall syndrome. Teratology, 1995. Presented at the Teratology Society Meeting, Newport Beach, CA., June 24-29, 1995. 258. Biesecker LG, Kang S, Abbott M, Allen J, Olney A, Grebe T, Clericuzio C, Graham JM Jr: Linkage studies in Pallister-Hall syndrome. Proceedings of the Greenwood Genetics Center, 15:161, 1996. Presented at the X V I David W. Smith Workshop on Malformations and Morphogenesis, Big Sky, Montana, July 29-August 3, 1995. 259. Graham JM Jr, Lewis RA, Dobyns WB: Cerebro-Oculo-Facial-Skeletal (COFS) syndrome: one spectrum of variable severity, or multiple separate syndromes. Proceedings of the Greenwood Genetics Center, 15:179, 1996. Presented at the X V I David W. Smith Workshop on Malformations and Morphogenesis, Big Sky, Montana, July 29-August 3, 1995. 260. Krakow D., Biesecker L., Van Dop C., Graham J.M. Jr.: Acrodysostosis: is it a G protein abnormality? Proceedings of the Greenwood Genetics Center, 15:165, 1996. Presented at the X V I David W. Smith Workshop on Malformations and Morphogenesis, Big Sky, Montana, July 29-August 3, 1995. 261. Kang S., Graham J.M. Jr., Abbott M., Biesecker L.G.: Linkage analysis of Pallister-Hall syndrome. American Journal of Human Genetics 57:A324, 1995. 262. Graham J.M. Jr.: Fibroblast growth factors and receptors: their role in morphogenesis. American Journal of Human Genetics 57:31, 1995. Presented at the American Society of Human Genetics Meeting, Minneapolis, MN, October 24-28, 1995. 263. Graham JM Jr., Zackai EH, Lewis RA, Dobyns WB: Delineation of cerebro-oculo-facialskeletal (COFS) syndrome. Journal of Investigative Medicine 44:130A, 1996. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, February 15-18, 1996. 264. Krakow D, Biesecker L, Van Dop C, Lachman R, Rimoin DL, Graham JM Jr: Acrodysostosis: Is it a G protein abnormality? Journal of Investigative Medicine 44:131A, 1996. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, February 15-18, 1996. 265. Biesecker LG, Kang S, Allen JC, Grebe TA, Clericuzio CL, Haskins-Olney AH, Graham JM Jr.: Clinical and genetic analysis of Pallister-Hall syndrome. Pediatric Research 39:470, 1996. Presented at the American Pediatric Society and Society for Pediatric Research Annual Meeting, Washington, DC, May 6-10, 1996. 266. Graham JM Jr., Zackai EH, Lewis RA, Dobyns WB: Delineation of cerebro-oculo-facialskeletal (COFS) syndrome. Pediatric Research 39:478, 1996. Presented at the American Pediatric Society and Society for Pediatric Research Annual Meeting, Washington, DC, May 6 10, 1996. 267. Graham JM Jr., Zackai EH, Lewis RA, Dobyns WB: Lumping and splitting within the cerebrooculo-facial skeletal (COFS) spectrum of disorders. Teratology 53:18, 1996. Presented at the Teratology Society Meeting, Keystone, CO, June 22-27, 1996. Printed January 28, 2015 - Page 60 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 91 of 130 PAGEID #: 42395 EXHIBIT 1 268. Kang S, Graham JM Jr., Abbott M, Schaffer A, Green ED, Rosenberg M, Allen J, Clericuzio C, Grebe T, Haskins-Olney A, Biesecker LG: Autosomal dominant Pallister-Hall syndrome maps to 7p13. Proceedings of the Greenwood Genetics Center, 16:126, 1997. Presented at the XVII David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead, CA, September 26-October 1, 1996. 269. Krantz D, Rand EB, Genin A, Jones M, Bhatt S, Graham JM Jr, Piccoli DA, Spinner NB: Frequency and consequences of 20p12 deletions in Alagille syndrome. Proceedings of the Greenwood Genetics Center, 16:197-198, 1997. Presented at the XVII David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead, CA, September 26-October 1, 1996. 270. Dibbern K, Rabinowitz Y, Graham JM Jr.: Natural history and surgical treatment of cryptophthalmos in Fraser syndrome. Proceedings of the Greenwood Genetics Center, 16:137 138, 1997. Presented at the XVII David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead, CA, September 26-October 1, 1996. 271. Thomas JA, Pepkowitz S, Graham JM Jr.: Microtia, renal agenesis, and DiGeorge sequence: A new syndrome or diabetic embryopathy? Proceedings of the Greenwood Genetics Center, 16:148-149, 1997. Presented at the XVII David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead, CA, September 26-October 1, 1996. 272. Lucas BC, Cooney DF, Graham JM Jr.: Treatment of plagiocephaly-torticollis deformation sequence. Proceedings of the Greenwood Genetics Center, 16:170-171, 1997. Presented at the XVII David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead, CA, September 26-October 1, 1996. 273. Kerner B, Flaum E, Mathews H, Carlson DE, Pepkowitz SH, Hixon H, Graham JM Jr.: Cervical teratoma: Prenatal diagnosis and long term follow-up. Proceedings of the Greenwood Genetics Center, 16:222-223, 1997. Presented at the XVII David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead, CA, September 26-October 1, 1996. 274. Sampson PD, Streissguth AP, Bookstein FL, Little RE, Clarren SK, DeHaene P, Hanson JW, Graham JM Jr: The incidence of fetal alcohol syndrome and the prevalence of alcohol-related neurodevelopmental disorder. Proceedings of the Greenwood Genetics Center,16:242, 1997. Presented at the XVII David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead, CA, September 26-October 1, 1996. 275. Kang S, Graham JM Jr, Abbott M, Schaffer A, Green ED, Rosenberg M, Allen J, Cleriuzio C, Grebe T, Haskins-Olney A, Biesecker LG. Autosomal dominant Pallister-Hall syndrome maps to 7p13. American Journal of Human Genetics, 59:A17, 1996. Presented at the American Society of Human Genetics Meeting, San Francisco, CA, October 29-November 2, 1996. 276. Godfrey M, Wang M, Belleh S, Mathews K, Wahl M, Cederbaum SD, Graham JM Jr, and Clericuzio CL. Clinical and molecular comparisons between severe forms of the Marfan syndrome and congenital contractural arachnodactyly (CCA). American Journal of Human Genetics, 59:A26, 1996. Presented at the American Society of Human Genetics Meeting, San Francisco, CA, October 29-November 2, 1996. Printed January 28, 2015 - Page 61 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 92 of 130 PAGEID #: 42396 EXHIBIT 1 277. Kerner B, Hixon H, Crandall B, and Graham JM Jr. Microcephalic lissencephaly, cleft palate, congenital heart defect, and contractures with absence of the corticospinal tract: a new syndrome? American Journal of Human Genetics, 59:A96, 1996. Presented at the American Society of Human Genetics Meeting, San Francisco, CA, October 29-November 2, 1996. 278. Dibbern K and Graham JM Jr. Two patients with FG syndrome and unusual additional physical fingings. Journal of Investigative Medicine, 45:128A, 1997. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, February 6-8, 1997. 279. Graham J.M. Jr.: Exposure to electromagnetic fields from a 60Hz power line source and occurrence of bilateral nephroblastomatosis and Wilms tumor. Proceedings of the Thirty-Second Annual Meeting, in press, 1997. Presented at 33rd Annual Meeting of National Council on Radiation Protection and Measurements, Arlington VA, April 2-3, 1997. 280. Graham J.M. Jr.: Dysmorphology and Teratology Club Symposium: Human developmental genes and phenotypes. Presented at the Pediatric Academic Societies' 1997 Annual Meeting, Washington DC, May 4, 1997. 281. Graham J.M. Jr.: Comparison of velo-cardio-facial syndrome with CHARGE association. Invited Presentation at the Seventh Biennial Southern African Society of Human Genetics Congress, Pilanesberg National Park, South Africa, May 18-21, 1997. 282. Graham J.M. Jr. and Biesecker L.G.: Autosomal dominant Pallister-Hall syndrome maps to GLI3 on 7p13. Presented at the Seventh Biennial Southern African Society of Human Genetics Congress, Pilanesberg National Park, South Africa, May 18-21, 1997. 283. Graham J.M. Jr. and Wang E.W.: Craniosynostosis syndromes and FGFR3 mutations without problems in long bone development. Presented at the Third International Skeletal Dysplasia Meeting, Marina Del Rey CA, August 7-9, 1997. 284. Graham J.M. Jr. and Wang E.W.: Craniosynostosis syndromes and FGFR3 mutations without problems in long bone development. Proceedings of the Greenwood Genetics Center, 17:70, 1998. Presented at the XVIII David W. Smith Workshop on Malformations and Morphogenesis, Pawleys Island SC, August 13-17, 1997. 285. Krantz I.D., Li L., Collins C.C., Costa T., Pierpont M.E.M., Piccoli D.A., Hood L., Graham J.M. Jr., and Spinner N.B. Alagille syndrome is caused by mutations in human Jagged1, a ligand for Notch1. Proceedings of the Greenwood Genetics Center, 17:130-131, 1998. Presented at the XVIII David W. Smith Workshop on Malformations and Morphogenesis, Pawleys Island SC, August 13-17, 1997. 286. Graham J.M. Jr. and Jabs E.W.: Use of helmets postoperatively in craniosynostosis syndromes. Journal of Craniofacial Genetics and Developmental Biology, 18:8, 1998. Presented at the 1997 Annual Meeting of the Society of Craniofacial Genetics, Baltimore MD, October 28, 1997. 287. Graham J.M. Jr. and Biesecker L.G.: The Inaugural Tony Lipson Memorial Lecture: Autosomal dominant Pallister-Hall syndrome maps to GLI3 on 7p13. Invited presentation at the Fifth Printed January 28, 2015 - Page 62 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 93 of 130 PAGEID #: 42397 EXHIBIT 1 International Federation of Teratology Societies Conference, Sydney, N.S.W., Australia, November 16-19, 1997. 288. Graham J.M. Jr.: Comparison of velo-cardio-facial syndrome with CHARGE association. Invited presentation at the Fifth International Federation of Teratology Societies Conference, Sydney, N.S.W., Australia, November 16-19, 1997. 289. Schweitzer D.N., Przylepa K.A., Graham J.M. Jr., Lachman R.S., and Jabs E.W.: Subtle radiographic findings in Crouzon syndrome with acanthosis nigracans. Journal of Investigative Medicine, 46:120A, 1998. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, February 5-7, 1998. 290. Graham J.M. Jr.: Ears you ought to know. Invited presentation at International Conference on Ear Reconstruction `98: Choices for the Future, Chateau Lake Louise Banff National Park, Alberta, Canada, March 4-6, 1998. 291. Graham J.M. Jr.: Lipomas and spinal lesions in Proteus syndrome. Invited presentation at NIH Proteus Syndrome Workshop. National Human Genome Research Institute. National Institutes of Health, BethesdaMD, March 19-20, 1998. 292. Shin S., Biesecker L.G., Graham J.M. Jr.: GLI3 transcription factor mutations, subcellular localization, and repressor/activator functions correlate with the genesis of three distinct human limb malformation syndromes. Presented at the 6th International Limb Development and Regeneration Conference. Teratology, 57:111, 1998. Sun Valley ID, May 17-21, 1998. 293. Graham J.M. Jr., Greenberg C.R., Busch D.: U V sensitivity in COFS, MICRO, and Cockayne syndromes - a spectrum of disorders. Teratology, 57:196, 1998. Presented at the Teratology Society Meeting, San Diego CA, June 21-25, 1998. 294. Graham J.M. Jr, Superneau D., Rogers R.C., Corning K., Schwartz C.E., Dykens E.M.: Behavioral and personality characteristics in FG syndrome. Proceedings of the Greenwood Genetics Center, 18:152, 1999. Presented at the X IX David W. Smith Workshop on Malformations and Morphogenesis, Whistler B.C., August 6-10, 1998. 295. Shah B., O 'Connor M., Cronin P., Graham J.: Psychopathology in children with varying levels of prenatal alcohol exposure. Scientific Proceedings 14:129. Presented at the 45th Annual Meeting of the American Academy of Child and Adolescent Psychiatry, Anaheim CA, October 26-November 1, 1998. 296. Graham J.M. Jr., Lucas B.: Confirmation of Bosma arhinia microphthalmia syndrome. Presented at the 1998 Annual Meeting of the Society of Craniofacial Genetics, Denver CO, October 27, 1998. 297. Graham J.M. Jr., Greenberg C.R., Anyane-Yeboa K., Jaspers N .G.J., Raams, A., Coleman D.M., Ziffer, D.W., Busch D.: COFS syndrome caused by defective nucleotide excision repair. American Journal of Human Genetics, 63:A33, 1998. Presented at the American Society of Human Genetics Meeting, Denver CO, October 27-31, 1998. Printed January 28, 2015 - Page 63 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 94 of 130 PAGEID #: 42398 EXHIBIT 1 298. Lev-Lehman E., Nawaz Z., Benton C., Dicks D., Graham J.M. Jr., Beaudet A.L.: Analysis of mutations causing Angelman syndrome: mRNA stability and UBE3A activity. American Journal of Human Genetics, 63:A332, 1998. Presented at the American Society of Human Genetics Meeting, Denver CO, October 27-31, 1998. 299. Graham J.M. Jr., Greenberg C.R., Anyane-Yeboa K., Jaspers N .G.J., Raams, A., Coleman D.M., Ziffer, D.W., Busch D.: COFS syndrome may be allelic with Cockayne syndrome and both disorders result from defective nucleotide excision repair. Presented at the 8th Manchester Birth Defects Conference, Manchester UK, November 10-13, 1998. 300. Graham J.M. Jr.: Cole-Hughes macrocephaly-mental metardation syndrome. Presented at the 8th Manchester Birth Defects Conference, Manchester UK, November 10-13, 1998. 301. Graham J.M. Jr, Superneau D., Rogers R.C., Corning K., Schwartz C.E., Dykens E.M.: Behavioral and personality characteristics in FG syndrome. Presented at the 5th International Symposium for the Study of Behavioral Phenotypes, Baltimore MD, November 18-21, 1998. 302. Naqvi S.S., Graham J.M. Jr.: Cole-Hughes macrocephaly-mental metardation syndrome. Presented at the 5th International Symposium for the Study of Behavioral Phenotypes, Baltimore MD, November 18-21, 1998. 303. Graham J.M. Jr.: Cole-Hughes macrocephaly-mental metardation syndrome and associated autistic features. Journal of Investigative Medicine 47:55A, 1999. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, January 27-30, 1999. 304. Graham J.M. Jr.: Cole-Hughes macrocephaly-mental metardation syndrome and associated autistic features. Pediatric Research, 45:74A, 1999. Presented at the Pediatric Academic Societies Annual Meeting, San Francisco CA, May 1-4, 1999. 305. Graham J.M. Jr.: Bosma arhinia microphthalmia syndrome. Pediatric Research, 45:74A, 1999. Presented at the Pediatric Academic Societies Annual Meeting, San Francisco CA, May 1-4, 1999. 306. Graham J.M. Jr.: Bosma arhinia microphthalmia syndrome. Teratology, 59:389, 1999. Presented at the Teratology Society Meeting, Keystone CO, June 28-July 3, 1999. 307. Graham J.M. Jr., Smith A.K., Lachman R.S., Tolo V.T.: Acrodysostosis associated with spinal stenosis. Proceedings of the Greenwood Genetics Center, 19:184,2000. Presented at the 4th International Skeletal Dysplasia Meeting, Baden-Baden Germany, July 29-August 1, 1999. 308. Salazar D., Graham J.M. Jr., Lachman R.S., Rimoin D.L., Wilcox W.R.: Spondylometaphyseal dysplasia, giant cell type. Proceedings of the Greenwood Genetics Center, 19:188, 2000. Presented at the 4th International Skeletal Dysplasia Meeting, Baden-Baden Germany, July 29August 1, 1999. 309. Graham J.M. Jr.: Bosma arhinia microphthalmia syndrome. Proceedings of the Greenwood Genetics Center, 19:76, 2000. Presented at the X X David W. Smith Workshop on Malformations and Morphogenesis, Schlangenbad Germany., August 4-8, 1999. Printed January 28, 2015 - Page 64 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 95 of 130 PAGEID #: 42399 EXHIBIT 1 310. Kerner, B., Graham, J.M ., Jr., Golden, J.A., Pepkowitz, S.H., Dobyns, W.B.: Familial lissencephaly with cleft palate and severe cerebellar hypoplasia. Proceedings of the Greenwood Genetics Center, 19:68-69, 2000. Presented at the X X David W. Smith Workshop on Malformations and Morphogenesis, Schlangenbad Germany., August 4-8, 1999. 311. Lachman R.S., Graham J.M. Jr., Smith A.K., Tolo V.T.: Acrodysostosis associated with spinal stenosis. Proceedings of the Greenwood Genetics Center, 19:91-92, 2000. Presented at the X X David W. Smith Workshop on Malformations and Morphogenesis, Schlangenbad Germany., August 4-8, 1999. 312. Biesecker L.G., Graham J.M. Jr., Grebe T., Neri G., Pagon R., Bonneman C., Partington M., Kiloran C.: Mutational spectrum of Pallister-Hall syndrome. American Journal of Human Genetics, 65:A284, 1999. Presented at the American Society of Human Genetics Meeting, San Francisco CA, October 19-23, 1999. 313. Ludecke H.-J., Graham J.M. Jr., Lindow S., Horsthemke B.: Is there a "Golderhar " gene in 4p15.3? American Journal of Human Genetics, 65:A229, 1999. Presented at the American Society of Human Genetics Meeting, San Francisco CA, October 19-23, 1999. 314. Everman D.B., Polinkovsky A., Francomano C.A., Graham J.M. Jr., Goodman F.R., Neri G., Morrison S., Robin N.H., Warman M.L.: Additional CDMP1 mutations suggest that brachydactyly type C is locus homogeneous and incompletely penetrant. American Journal of Human Genetics, 65:A294, 1999. Presented at the American Society of Human Genetics Meeting, San Francisco CA, October 19-23, 1999. 315. Graham J.M. Jr., Meira L.B., Greenberg C.R., Jaspers N .G.J., Busch D., Coleman D.M., Ziffer D. W., Friedberg E.C.: Original COFS syndrome Manitoba aboriginal kindred has a mutation in the Cockayne syndrome group B (CSB) gene. American Journal of Human Genetics, 65:A299, 1999. Presented at the American Society of Human Genetics Meeting, San Francisco CA, October 19-23, 1999. 316. Schweitzer D.N., Lachman R.S., Pressman B.D., Graham J.M. Jr.: Further delineation of the Van Den Ende-Gupta syndrome of blepharophimosis, joint contractures, arachnodactyly and normal development. American Journal of Human Genetics, 65:A343, 1999. Presented at the American Society of Human Genetics Meeting, San Francisco CA, October 19-23, 1999. 317. Graham J.M. Jr., Meira L.B., Greenberg C.R., Busch D., Ziffer D.W., Coleman D.M., Friedberg E. C.: Original COFS syndrome kindred from Manitoba has a mutation in the Cockayne syndome group B (CSB) gene. Journal of Investigative Medicine 48:48A, 2000. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, February 9-12, 2000. 318. Gordon O.K., Earl D.L., Kreutzman J.T., Hwang J.M ., Graham J.M. Jr.: Vertex birth molding: longterm residual effects and suggested management of cone-headed neonates. Journal of Investigative Medicine 48:48A, 2000. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, February 9-12, 2000. Printed January 28, 2015 - Page 65 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 96 of 130 PAGEID #: 42400 EXHIBIT 1 319. Schweitzer D.N., Earl D.L., Graham J.M ., Jr.: Marden-Walker syndrome: case report and review. Genetics in Medicine 2:87, 2000. Presented at Presented at the Annual Clinical Genetics Meeting, Palm Springs, CA, March 9-12, 2000. 320. Graham J.M. Jr., Meira L.B., Greenberg C.R., Busch D.B., Doughty A.T.B., Ziffer D.W., Coleman D.M., Savre-Train I., Friedberg E.C.: Original COFS syndrome kindred from Manitoba has a mutation in the Cockayne syndome group B (CSB) gene. Pediatric Research 47:81A, 2000. Presented at the Pediatric Academic Societies Meeting, Boston MA, May 12-16, 2000. 321. Naqvi S.S.A., Graham J.M. Jr.: Autosomal dominant macrocephaly and autism. Presented at the American Psychiatric Association Annual Meeting, Chicago IL, May 13-15, 2000. 322. Graham J.M. Jr., Krakow D., Lachman R.S.: Radiographic findings and Gs-alpha bioactivity studies and mutation screening in acrodysostosis indicate a different etiology from pseudohypoparathyroidism. Developmental Dynamics, 219:444, 2000. Presented at 7th International Conference on Limb Development and Regeneration, Aussois France, May 21-24, 2000. 323. Graham J.M. Jr., Anyane-Yeboa K., Jaspers N .G.J., Coleman D., Ziffer D.W., Busch D.B.: Genotype-phenotype correlations in COFS syndrome. European Journal of Human Genetics 8:51, 2000. Presented at the European Human Human Genetics Conference 2000, Amsterdam, The Netherlands, May 27-30, 2000. 323. Graham, J.M ., Jr.: Management of fragile X syndrome. Presented at 7thInternational Fragile X Conference. Los Angeles CA., July 19-23, 2000 (Invited Talk). 324. Schwartz C.E., May M., Neri G., Gillessen-Kaesbach G., Graham J.M. Jr., Scott C., Stevenson R.E.: The Aaarskog-Scott syndrome most frequently results from mutations giving rise to a truncated protein. Proceedings of the Greenwood Genetics Center, 20:162-163, 2001. Presented at the X X I David W. Smith Workshop on Malformations and Morphogenesis, San Diego CA, August 1-6, 2000. 325. Wang R., Earl D.L., Ruder R.O., Graham J.M. Jr.: Syndromic ear anomalies and renal ultrasounds. Proceedings of the Greenwood Genetics Center, 20:170, 2001. Presented at the X X I David W. Smith Workshop on Malformations and Morphogenesis, San Diego CA, August 1-6, 2000. 326. Graham, J.M ., Jr.: Trigonocephaly and the Opitz C syndrome. Proceedings of the Greenwood Genetics Center, 20:68-69, 2001. Presented at the X X I David W. Smith Workshop on Malformations and Morphogenesis, San Diego CA, August 1-6, 2000. 327. Schweitzer D.N., Yano S., Earl D.L., Graham J.M ., Jr.: Johnson-McMillin syndrome, a neuroectodermal syndrome with conductive hearing loss and microtia: report of a new case. American Journal of Human Genetics, 67:118, 2000. Presented at the American Society of Human Genetics Meeting, Philadelphia PA, October 2-6, 2000. Printed January 28, 2015 - Page 66 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 97 of 130 PAGEID #: 42401 EXHIBIT 1 328. Graham, J.M ., Jr.: Phenotype and dosage effect in polysomy X and polysomy Y (48,XXXY; 48,XXYY; 49,XXXXY): Clinical consequence and deductions. Presented at XXY/Klinefelter syndrome in 2000: expanding the phenotype and identifying new research directions. National Institutes of Health, BethesdaMD, August 28-29, 2000 (Invited Talk). 329. Graham, J.M ., Jr., Schweitzer, D.N., Earl, D.L., Lachman, R.S.: Marden-Walker syndrome and Van Den Ende-Gupta syndrome: clinical delineation and review of differentiating features. Presented at the 9th Manchester Birth Defects Conference, Manchester UK, November 7-10, 2000. 330. Wang R., Earl D.L., Ruder R.O., Graham J.M. Jr.: Syndromic ear anomalies and renal ultrasounds. Journal of Investigative Medicine 49(1):52A, 2001. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, February 7-10, 2001. 331. Elliott, A.M., Graham, J.M ., Jr., Curry, C., Pal, T., Rimoim, D.L., Lachmam, R.S. : Dolichospondylic Dysplasia and the 3-M Syndrome: A Spectrum or Distinct Entities? Genetics in Medicine 3:65, 2001. Presented at Presented at the Annual Clinical Genetics Meeting, Miami FL, March 1-4, 2001. 332. Wang, R., Graham, J.M.Jr.: Inhibition of neural crest cell migration by hyperglycemia: a possible mechanism of teratogenesis in infants of diabetic mothers? Teratology 63:286, 2001. Presented at the Teratology Society Meeting, Montreal, Quebec CA June 23-28, 2001. 333. White SM, Goodman F, Graham JM Jr., Everman D., Delatycki MB, Lachman RS, Rimoin DL, Warman ML, Savarirayan R,: Broad phenotypic spectrum caused by an identical heterozygous CDMP1 mutation in three unrelated families. Presented at the 5th International Skeletal Dysplasia Meeting, Oxford, UK, September 6-8, 2001. 334. Wang R., Danielpour M., Gruskin D., Graham J.M ., Jr.: Dandy Walker malformation and tethered spinal cord: a new association? Proceedings of the Greenwood Genetics Center, 21:82 83, 2002. Presented at the XXII David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead CA, September 7-11, 2001. 335. Dawson K., Gruskin D., Kreutzmann J., Pepkowitz S.H., Graham J.M ., Jr.: A rapidly progressive myopathy which presented as torticollis and tight hips. Proceedings of the Greenwood Genetics Center, 21:132-133, 2002. Presented at the XXII David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead CA, September 7-11, 2001. 336. Wheeler P. Graham J.M ., Jr., Cox T., Lin A., Hall B., Schwartz C.: Two brothers with coloboma, distinctive facial features, short stature and mental retardation: CHARGE association, X-linked mental retardation, FG syndrome or unique condition? Proceedings of the Greenwood Genetics Center, 21:140-141, 2002. Presented at the XXII David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead CA, September 7-11, 2001. Printed January 28, 2015 - Page 67 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 98 of 130 PAGEID #: 42402 EXHIBIT 1 337. Visootsak J., Graham J.M ., Jr., Hoyme H.E., Szeftel R., Connor M., Schelley S., Schwartz C., Dykens E.: A new family with Borjeson-Forssman-Lehmann syndrome (BFLS): clinical and behavioral features. Proceedings of the Greenwood Genetics Center, 21:141-142, 2002. Presented at the X X II David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead CA, September 7-11, 2001. 338. Graham J.M ., Jr., Earl D.L., Danielpour M., Jabs E.W.: A patient with Boston craniosynostosis. Proceedings of the Greenwood Genetics Center, 21:144, 2002. Presented at the XXII David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead CA, September 7-11, 2001. 339. White S.M., Graham, J.M ., Jr., Goodman F.R., Everman D., Delatycki M.B., Lachman R.S., Rimoin D.L., Warman M .L.., Savarirayan R.: Broad phenotypic spectrum caused by an identical heterozygous CDMP1 mutation in three unrelated families. Proceedings of the Greenwood Genetics Center, 21:165-166, 2002. Presented at the XXII David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead CA, September 7-11, 2001. 340. Graham J.M ., Jr., Wheeler P., Lin A.E., Hall B.D., Cox T.C., Schwartz C.E.: A new X-linked syndrome with similarity to CHARGE association, Toriello-Carey syndrome, and FG syndrome. Genetic Counseling in press, 2001. Presented at the 10thInternational Workshop on X-linked Mental Retardation. Frascati Italy, September 19-22, 2001. 341. Graham J.M ., Jr., Earl D.L., Danielpour M., Jabs E.W.: A patient with Boston craniosynostosis. Presented at the Society for Craniofacial Genetics Meeting, San Diego CA, October 12, 2001. 342. Graham J.M ., Jr., Wheeler P., Lin A.E., Hall B.D., Cox T.C., Schwartz C.E.: A new X-linked syndrome with similarity to CHARGE association, Toriello-Carey syndrome, and FG syndrome. American Journal of Human Genetics 69:310, 2001. Presented at the American Society of Human Genetics Meeting, San Diego CA, October 12-16, 2001. 343. Villard L., Nguyen K., Cardoso C., Lese C., Weiss A., Sifry-Platt, Grix A.W., Graham, J.M. Jr., Winter R.M., Leventer R.J., Dobyns W.B.: X-linked bilateral perisylvian polymicrogyria maps to Xq. American Journal of Human Genetics 69:500, 2001. Presented at the American Society of Human Genetics Meeting, San Diego CA, October 12-16, 2001. 344. De Mollerat X .J., Everman D., Clarkson K., Rogers C., Aylsworth A., Graham J.M ., Jr., Stevenson R.E., Schwartz C.E.: p63 mutations are not a major cause of non-syndromic SHSF. American Journal of Human Genetics 69:629, 2001. Presented at the American Society of Human Genetics Meeting, San Diego CA, October 12-16, 2001. 345. Wang R, Danielpour M, Gruskin D, Graham JM, Jr.: Dandy Walker malformation and tethered spinal cord: a new association? Presented at the 2001 American Association of Neurologic Surgeons, Section on Pediatric Neurological Surgery Meeting, New York, NY, Nov. 28 - Dec. 1, 2001. Printed January 28, 2015 - Page 68 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 99 of 130 PAGEID #: 42403 EXHIBIT 1 346. Visootsak J., Graham J.M ., Jr., Hoyme H.E., Szeftel R., Connor M., Schelley S., Schwartz C., Dykens E.: A new family with Borjeson-Forssman-Lehmann syndrome (BFLS): clinical and behavioral features. Journal of Investigative Medicine 50(1):54A, 2002. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, February 6-9, 2002. 347. Donahue K., Graham, J.M ., Jr.: Deformation of the human infant cranium. Abstract Book, page A99. Presented at American Association for the Advancement of Science Annual Meeting. Boston MA, February 14-19, 2002. 348. Graham, J.M ., Jr.: An academic practice model for clinical genetics services. Abstract Book, page 100. Presented at the Annual Clinical Genetics Meeting, New Orleans, LA, March 14-17, 2002. 349. Sanchez P.A., Graham J.M ., Jr., Relan A.: Digital dysmorphology cases: development of interactive, on-line genetics cases. Abstract Book, page 84. Presented at the Annual Clinical Genetics Meeting, New Orleans, LA, March 14-17, 2002. 350. Graham J.M ., Jr.: Abnormal head shapes. Invited presentation. 10thAnnual Conference on Advanced Practice in Neonatal Care, Atlanta Georgia, April 11-12, 2002. 351. Graham J.M ., Jr.: Ear anomalies and facial clefting. Invited presentation. 10thAnnual Conference on Advanced Practice in Neonatal Care, Atlanta Georgia, April 11-12, 2002. 352. Visootsak J., Dykens E., Schwartz C., Graham J.M ., Jr.: Clinical and behavioral features of Borjeson-Forssman-Lehmann Syndrome (BFLS), compared with Prader-Willi Syndrome (PWS) and Klinefelter Syndrome (KS) variants. Pediatric Research, 51:24A, 2002, Presented at the Pediatric Academic Societies Meeting, Baltimore, MD, May 4-7, 2002. 353. Graham J.M ., Jr., Gomez M., Earl D., Kreutzman J., Guo X.: Management and outcomes in 308 cases of torticollis-plagiocephaly deformation sequence. Pediatric Research, 51:150A 2002, Presented at the Pediatric Academic Societies Meeting, Baltimore, MD, May 4-7, 2002. 354. Graham J.M ., Jr.: Behavioral and clinical features of FG syndrome. Invited presentation. FG Family Support Group Meeting, Salt Lake City UT, June 20-21, 2002. 355. Graham J.M ., Jr.: Diagnosis and management of environmentally determined head shape abnormalities. Teratology 65:301, 2002. Presented at the Teratology Society Meeting, Scottsdale AZ, June 22-27, 2002. 356. Visootsak J., Dykens E., Graham J.M ., Jr.: Clinical and behavioral features of Klinefelter Syndrome (KS) variants: 48,XXYY compared to 48,XXXY and 49,XXXXY. Presented at the Society for Developmental and Behavioral Pediatrics Annual Scientific Meeting and Workshops, Seattle WA, September 26-30, 2002. Printed January 28, 2015 - Page 69 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 100 of 130 PAGEID #: E424041 357. De Mollerat X .J., Everman D.B., Morgan C.T., Clarkson K.B., Rogers R.C., Colby R.S., Aylsworth A.S., Graham J.M ., Jr., Stevenson R.E., Schwartz C.E.: p63 mutations are not a major cause of non-syndromic split hand/foot malformation. Proceedings of the Greenwood Genetics Center, 22:145, 2003. Presented at the XXIII David W. Smith Workshop on Malformations and Morphogenesis, Greenville SC, August 7-11, 2002. 358. Graham, J.M ., Jr., Earl D.L., Krahn K.N., Murray J: Brachydactyly D with cleft lip and scoliosis, a new broadly variable autosomal dominant syndrome. Proceedings of the Greenwood Genetics Center, 22:101-102, 2003. Presented at the XXIII David W. Smith Workshop on Malformations and Morphogenesis, Greenville SC, August 7-11, 2002. 359. Graham J.M ., Jr., Visootsak J., Schwartz C., Rosner B., Dykens E.: Behavioral features of Borjeson-Forssman-Lehmann Syndrome (BFLS), compared with Prader-Willi Syndrome (PWS) and Klinefelter Syndrome (KS) variants. Genetic Counseling, 13:in press, 2002. Presented at the XIIIth European Meeting on Dysmorphology, Strasbourg FRANCE, September 4-7, 2002. 360. Graham, J.M ., Jr., Earl D.L., Krahn K.N., Murray J: Brachydactyly D with cleft lip and scoliosis, a new broadly variable autosomal dominant syndrome. Genetic Counseling, 13:in press, 2002. Presented at the XIIIth European Meeting on Dysmorphology, Strasbourg FRANCE, September 4-7, 2002. 361. Lalani S.R., Stockton D.W., Bacino C., Molinari L.M., Glass N.L., Fernbach S.D., Towbin J.A., Craigen W .J., Graham, J.M ., Jr., Hefner M.A., Lin A.E., McBride K.L.., Davenport S.L., Martin D. Belmont J.W.: Toward a genetic etiology of CHARGE syndrome. American Journal of Human Genetics 71:281, 2002. Presented at the American Society of Human Genetics Meeting, Baltimore MD, October15-19, 2002. 362. Dawson, K.G., Sebald E., Graham J.M ., Jr., Krakow D.: Mutation detection in NOGGIN in individuals with multiple synostosis syndrome. American Journal of Human Genetics 71:255, 2002. Presented at the American Society of Human Genetics Meeting, Baltimore MD, October15-19, 2002. 363. Graham J.M ., Jr., Visootsak J., Rosner B., Dykens E.: Behavioral features of FG Syndrome. Presented at the Society for the Study of Behavioural Phenotypes Meeting, Whistler BC, November 1-4, 2002. 364. Visootsak J., Dykens E., Schwartz C., Rosner B., Graham J.M ., Jr.: Behavioral features of Borjeson-Forssman-Lehmann Syndrome (BFLS), compared with Prader-Willi Syndrome (PWS) and Klinefelter Syndrome (KS) variants. Presented at the Society for the Study of Behavioural Phenotypes Meeting, Whistler BC, November 1-4, 2002. 365. Graham J.M ., Jr.: How scientific is physical measurement in behavioral phenotypes? A consideration of the proportional effects of extra X chromosomes on dysmorphic features, language and developmental-behavioral outcomes in Klinefelter syndrome variants. Invited Presentation for the Society for the Study of Behavioural Phenotypes Meeting, Whistler BC, November 1-4, 2002. Printed January 28, 2015 - Page 70 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 101 of 130 PAGEID #: E424051 366. Graham J.M ., Jr., Visootsak J., Schwartz C., Rosner B., Dykens E.: Behavioral features of FG Syndrome. Presented at the 10th Manchester Birth Defects Conference, Manchester UK, November 19-22, 2002. 367. Visootsak J., Dykens E., Rosner B., Graham J.M ., Jr.: Clinical and behavioral features of Klinefelter syndrome (KS) variants: 48,XXYY compared to 48,XXXY and 49,XXXXY. Journal of Investigative Medicine 51:S150, 2003. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, January 29-February 1, 2003. 368. Graham J.M ., Jr., Visootsak J., Schwartz C., Rosner B., Dykens E.: Behavioral features of FG Syndrome. Journal of Investigative Medicine 51: S149, 2003. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, January 29-February 1, 2003. 369. Visootsak J., Dykens E., Rosner B., Graham J.M ., Jr.: Clinical and behavioral features of Klinefelter syndrome (KS) variants: 48,XXYY compared to 48,XXXY and 49,XXXXY. Pediatric Research 53: 81A. Presented at the Pediatric Academic Societies Meeting, Seattle, WA, May 3-6, 2003. 370. Graham J.M ., Jr., Visootsak J., White S.H., Rosner B., Dykens E., Schwartz C.: Clinical and behavioral features of Borjeson-Forssman-Lehmann Syndrome (BFLS) patients with mutations in PHF6. Pediatric Research 53: 81A. Presented at the Pediatric Academic Societies Meeting, Seattle, WA, May 3-6, 2003. 371. Graham, J.M. Jr., Wheeler P., Tackels-Horne D., Lin A.E., Hall B.D., May M., Short K.M., Schwartz C.E., Cox T.C.: A new X-linked syndrome with agenesis of the corpus callosum, mental retardation, coloboma, micrognathia, and a mutation in the Alpha 4 gene at Xq13, Presented at the Festscrift of Dr. Bryan Hall, Lake Arrowhead CA, March 12, 2003. 372. Lawand CMD, Blake KD, Prasad C, Graham JM Jr. The Cranial Nerve Anomalies of CHARGE association/syndrome (A/S). Paediatrics and Child Health. 8 (Supp B abstract 38): 26B, 2003. Presented at the 80thAnnual Meeting of the Canadian Paediartic Society, June 2003. 373. Issekutz KA, Smith IM, Prasad C, Graham JM Jr. Blake KD. The Incidence and Prevalence of CHARGE Association/Syndrome in Canada. Paediatrics and Child Health. 8 (Supp B abstract 38): 26B, 2003. Presented at the 80thAnnual Meeting of the Canadian Paediartic Society, June 2003. 374. Graham, J.M. Jr., Wheeler P., Tackels-Horne D., Lin A.E., Hall B.D., May M., Short K.M., Schwartz C.E., Cox T.C.: A new X-linked syndrome with agenesis of the corpus callosum, mental retardation, coloboma, micrognathia, and a mutation in the Alpha 4 gene at Xq13. Birth Defects Research: Part A Clinical and Molecular Teratology, 67:321, 2003. Presented at the Teratology Society Meeting, Philadelphia PA, June 21-26, 2003. 375. Graham, J.M ., Jr.: CHARGE syndrome: clinical and behavioral features. International CHARGE Syndrome Family Support Group Meeing, Invited Presentation, Cleveland OH, July 24-27, 2003. Printed January 28, 2015 - Page 71 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 102 of 130 PAGEID #: E424061 376. Graham J.M ., Jr., Kreutzman J., Earl D., Halberg A., Samayoa C., Guo X.: Redefinition of current infant head shape parameters and management ofpositional brachycephaly. Proceedings of the Greenwood Genetics Center, 23:75, 2004. Presented at the X X IV David W. Smith Workshop on Malformations and Morphogenesis, Vancouver BC, August 7-12, 2003. 377. Wang R., Visootsak J., Graham J.M ., Jr.: Midline defects in FG syndrome: does tethered spinal cord contribute to the phenotype? Proceedings of the Greenwood Genetics Center, 23:177-178, 2004. Presented at the X X IV David W. Smith Workshop on Malformations and Morphogenesis, Vancouver BC, August 7-12, 2003. 378. Earl D., Kreutzman J., Field F., Krakow D., Wilcox W., Rimoin D., Lachman R., Graham J.M ., Jr.: Larsen syndrome clinical and radiographic delineation. Journal of Investigative Medicine 52:S100, 2004. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, January 28-31, 2004. 379. Chu C., Rabinowitz Y., Bergwerk K., Scambler P., Graham J.M ., Jr.: Genotype-phenotype correlations of mutations in FRAS1 with Fraser syndrome patients. Journal of Investigative Medicine 52:S133, 2004. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, January 28-31, 2004. 380. Herman K., Honrubia D., Graham J.M ., Jr.: Opitz C trigonocephaly syndrome: a report of three affected siblings from one family. Journal of Investigative Medicine 52:S133, 2004. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, January 28-31, 2004. 381. Graham, J.M ., Jr.: Marshall Edwards Invited Lecture: Cranial deformation in human infants. Birth Defects Research: Part A Clinical and Molecular Teratology, in press, 2004. Presented at the Australian Birth Defects Society Annual Meeting. Brisbane, Australia, February 20-21, 2004. 382. Graham, J.M ., Jr.: Invited Lecture: New patterns of malformation in diabetic embryopathy. Birth Defects Research: Part A Clinical and Molecular Teratology, in press, 2004. Presented at the Australian Birth Defects Society Annual Meeting. Brisbane, Australia, February 20-21, 2004. 383. Graham, J.M ., Jr.: Invited Lecture: Genetic counseling for oculo-auricular-vertebral sequence. Birth Defects Research: Part A Clinical and Molecular Teratology, in press, 2004. Presented at the Australian Birth Defects Society Annual Meeting. Brisbane, Australia, February 20-21, 2004. 384. Visootsak J., Rosner B., Dykens, E., Graham, J.M ., Jr.: Behavioral features of CHARGE syndrome. Pediatric Research 55:272A, 2004. Presented at the Pediatric Academic Societies Meeting, San Francisco, CA, May 1-4, 2004. 385. Graham, J.M. Jr., Earl D., Kreutzman J., Lachman R., Rimoin D.L., Cohn D., Krakow D.: Clinical features in Larsen syndrome patients with FLNB mutations. Proceedings of the Greenwood Genetics Center, 24: 94, 2005. Presented at the X X V David W. Smith Workshop on Malformations and Morphogenesis, Wasatch Mountains, Utah, August 18-21, 2004. Printed January 28, 2015 - Page 72 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 103 of 130 PAGEID #: E424071 386. Krakow D., Graham Jr., J.M ., Robertson S.P., Sebald E. T., Morgan T., King L., Earl D., Kreutzman J., Lachman R.L., Rimoin D.L., Cohn D.H.: Mutations in the gene encoding filamin B disrupt vertebral segmentation, joint formation and skeletogenesis. Proceedings of the Greenwood Genetics Center, 24: 93, 2005. Presented at the X X V David W. Smith Workshop on Malformations and Morphogenesis, Wasatch Mountains, Utah, August 18-21, 2004. 387. Graham, J.M. Jr., Lachman R., Krakow D.: Larsen syndrome: suggested diagnostic criteria for FLNB mutation analysis. Presented at the 11thManchester Birth Defects Conference, Manchester England UK, November 9-12, 2004. 388. Aligianis, I., Johnson, C., Gissen, P., Chen, D., Morgan N.V., Hofman, K., Maina, E., Tee, L., Morton, J., Ainsworth, J.R., Stoodley, M., Pilz, D., Rosser, E., Cole T., Stolte-Dijktra, I., Fieggen, K., Clayton-Smith, J., Shields, J., Newbury-Ecob, R., Horn, D., Warburg M., Megabane, A., Dobyns, W., Graham, Jr., J.M ., Bond, J., Trembath, R., Harris, L., Takai, Y., Mundlos, S., Tannahill, D., Woods, C.G., Maher E.R.: Molecular genetics of MICRO syndrome and genotype-phenotype correlations. Presented at the 11thManchester Birth Defects Conference, Manchester England UK, November 9-12, 2004. 389. Conway R., Graham J.M ., Jr., Falk R.: The female phenotype of oto-palatal-digital syndrome type 2: a review and report of possible new features. Journal of Investigative Medicine 53:S99, 2005. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, February 2 5, 2005. 390. Graham, Jr., J.M.: Bosma arhinia microphthalmia syndrome. Presented at Judy Hall's Festscrift at the Western Society for Pediatric Research Meeting, Carmel, CA, February 2-5, 2005. 391. Graham, Jr., J.M ., Robertson S.P., Lachman R.S., Krakow D.: Genotype-phenotype correlations in Larsen syndrome. European Journal of Human Genetics 13 (Supplement 1): 131, 2005. Presented at European Society for Human Genetics Meeting, Prague CZ, May 7-10, 2005. 392. Casas K.A., Lee J., Hermam K., Graham J.M ., Jr., Li, S.: Pathogenesis of ring chromosome 14 syndrome. Presented at American College of Medical Genetics Meeting, Dallas T X , March 17 20, 2005. 393. Visootsak J., Schwenk K, Dykens E., Phelan MC, Graham, J.M ., Jr.: Adaptive and maladaptive behavior in 22q13 deletion syndrome compared to 5p- syndrome. Pediatric Research, 57:2301, 2005. Presented at the Pediatric Academic Societies Meeting, Washington, DC, May 14-17, 2005. 394. Graham, Jr. J.M. Symposium: Gene/environment interactions in rare diseases that include common birth defects. Presented at the Teratology Society Meeting, St. Pete Beach, FL, June 25 30, 2005. 395. Graham J.M ., Jr. and Visootsak J.: What's new in FG Syndrome? FGFamily Support Group Meeting. Boston MA. June 6-9, 2005. Printed January 28, 2015 - Page 73 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 104 of 130 PAGEID #: E424081 396. Graham, Jr. J.M ., Robertson S.P., Kramer N., Lachman R., Rock C., Krakow D: Joint dislocation disorders caused by mutations in FLNB. Invited Plenary Session Talk. Presented at Human Genetics Society of Australasia Annual Meeting, Newcastle NSW Australia. July 27-29, 2005. 397. Graham, Jr. J.M.: Differential diagnosis of disorders resulting in microcephaly, cataracts and microcornea. Invited Symposium Talk. Presented at Human Genetics Society of Australasia Annual Meeting, Newcastle NSW Australia. July 27-29, 2005. 398. Graham, Jr. J.M.: Diagnosis and management of CHARGE syndrome. Invited Dysmorphology Club Talk. Presented at Human Genetics Society of Australasia Annual Meeting, Newcastle NSW Australia. July 27-29, 2005. 399. Martinez J.A., Graham, Jr., J.M.: Klippel-Trenaunay syndrome: role of angiogenic factors in vascular malformations and overgrowth syndromes. Proceedings of the Greenwood Genetics Center, 25:104-105, 2006. Presented at the X X V I David W. Smith Workshop on Malformations and Morphogenesis, Iowa City, IA, August 1-5, 2005. 400. Conway R., Danielpour M., Graham, Jr., J.M.: Macrocephaly cutis marmorata telangiectatica congenita: an overgrowth syndrome with cutaneous vascular anomalies. Proceedings of the Greenwood Genetics Center, 25:91, 2006. Presented at the X X V I David W. Smith Workshop on Malformations and Morphogenesis, Iowa City, IA, August 1-5, 2005. 401. Vatanavicharn N., Graham, Jr., J.M.: Microduplication of genes in the PWS/AS region (15q1113) can cause different clinical phenotypes. Proceedings of the Greenwood Genetics Center, 25:102, 2006. Presented at the X X V I David W. Smith Workshop on Malformations and Morphogenesis, Iowa City, IA, August 1-5, 2005. 402. Adam, M.P., Schelley S., Gallagher R., Brady N., Barr K., Blumberg B., Shieh J.T.C., Graham, Jr., J.M ., Hudgins L., Mowat-Wilson syndrome: an under-recognized cause of severely impaired or absent speech. Proceedings of the Greenwood Genetics Center, 25,:84-85, 2006. Presented at the X X V I David W. Smith Workshop on Malformations and Morphogenesis, Iowa City, IA, August 1-5, 2005. 403. Graham, Jr. J.M ., Robertson S.P., Kramer N., Lachman R., Krakow D.: Genotype-phenotype correlations in Larsen syndrome. Proceedings of the Greenwood Genetics Center, 25,66, 2006. Presented at the X X V I David W. Smith Workshop on Malformations and Morphogenesis, Iowa City, IA, August 1-5, 2005. 404. Graham, Jr. J.M ., Robertson S.P., Kramer N., Lachman R., Rock C., Krakow D.: Genotypephenotype correlations in Larsen syndrome. Presented at 16thEuropean Meeting on Dysmorphology, Strasbourg France, September 7-10, 2005. 405. Lalani, S.R., Safiullah, A.A., Fernbach S.D., Molinari L.M., Bacino C.A., Davenport S.L., Heffner M .A., Graham, Jr., J.M ., Belmont J.W.: Spectrum on CHD7 mutations in 113 individuals with CHARGE syndrome. American Journal of Human Genetics Abstract 10:19, Presented at the American Society of Human Genetics Meeting, Salt Lake City UT, October 25 29, 2005. Printed January 28, 2015 - Page 74 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 105 of 130 PAGEID #: E424091 406. Lin A., Bird L., Gillessen-Kaessbach J.G ., Grossfeld P., Hamilton R., Hicks D., Innes M., Kerr B., Moog U., Rebolledo M. Vaux K., Wieczorek D., Graham, Jr., J.M ., Gripp K.: The spectrum of cardiovascular anomalies in Costello syndrome includes arteriopathy. American Journal of Human Genetics Abstract 624:132, Presented at the American Society of Human Genetics Meeting, Salt Lake City UT, October 25-29, 2005. 407. WangR., Jones J.R., Chen S., Rogers R.C., FriezM.J., Schwartz C.E., Graham Jr., J.M.: Extreme phenotypic variability and a new mutation in HLXB9 in a Currarino Syndrome kindred. American Journal of Human Genetics Abstract 703:145, Presented at the American Society of Human Genetics Meeting, Salt Lake City UT, October 25-29, 2005. 408. Graham, Jr., J.M.: Invited Speaker and Discussant: Descriptive terminology for the periocular region. 1stNIH Consensus Conference on Dysmorphology Nomenclature, Bethesda MD, December 8-10, 2005. 409. Vatanavicharn N., Graham Jr., J. M., Dawson K., Kohlhase J.: Discordant monozygotic twins with Wildervanck syndrome: a proposed mode of inheritance. Journal of Investigative Medicine 54:S100, 2006. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, February 1-4, 2006. 410. Visootsak J., Rosner B., Dykens E, Tartaglia N, Graham J.M ., Jr.: Adaptive and Maladaptive Behavior of Males with Sex Chromosome Aneuploidy. Journal of Investigative Medicine 54(1)S280, 2006. Presented at the Southern Society for Pediatric Research Meeting. Atlanta, GA, March 3-5, 2006. (SSPR Clinical Science Young Investigator Award) 411. Conway R.L., Zachai E., Hoyme H.E., Milunsky J.M ., Shieh J., Butler M .G., Crandall B., Zinn A., Dorosthar P.C., Graham Jr., J.M.: Macrocephaly-cutis marmorata telangiectatica congenita: a review of 13 patients with attention to clinical features and management. European Journal of Human Genetics14 (Supplement 1): 139, 2006. Presented at European Society for Human Genetics Meeting, Amsterdam NH, May 6-9, 2006. 412. Graham, Jr., J.M.: Invited Presentation: Urethral obstruction malformation sequence and other causes for prune belly syndrome. International Prune Belly Syndrome Support Group Meeting, Torrance CA, July 21, 2006. 413. Graham, Jr., J.M.: Invited Presentation: Differential diagnosis for cerebral overgrowth syndromes. International Sotos Syndrome Support Group Meeting, Orange CA, July 22, 2006. 414. Graham, Jr., J.M.: The morphogenesis of wormian bones. Proceedings of the Greenwood Genetics Center, 26:80-81, 2007. Presented at the 27th David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead CA, Sept 8-12, 2006. 415. Conway R.L., Danielpour M., Pressman B., Butler M .G., Zachai E., Close L., Clericuzio C., Graham Jr., J.M.: Longitudinal analysis of neuroimaging abnormalities in macrocephaly-cutis marmorata telangiectatica congenita. Proceedings of the Greenwood Genetics Center, 26:71-72, 2007. Presented at the 27th David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead CA, Sept 8-12, 2006. Printed January 28, 2015 - Page 75 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 106 of 130 PAGEID #: E424101 416. Pober B.R., Al-Gazi L., Lacombe D., Chassaing N., Bieth E., Donahoe P.K., McPherson E., Graham Jr., J.M ., Hill R.S., Walsh C., Kartarci S.: Locus mapping in Donnai-Barrow syndrome: approach to identify a gene important for congenital diaphragmatic hernia. Proceedings of the Greenwood Genetics Center, 26:53, 2007. Presented at the 27th David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead CA, Sept 8-12, 2006. 417. Vatanavicharn N., Wilcox, Jr., W.R., Graham Jr., J.M ., Curry C.J., Pepkowitz S., Lachman R.S., Rimoin D.L.: Diaphanospondylodysostosis (DSD): three new cases and similarities of DSD to the Pax1 knockout mouse. Proceedings of the Greenwood Genetics Center, 26:119, 2007. Presented at the 27th David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead CA, Sept 8-12, 2006. 418. Martinez J.A., Graham, Jr., J.M.: Signaling pathways in nail development: brachydactyly with nail aplasia. Proceedings of the Greenwood Genetics Center, 26:100-101, 2007. Presented at the 27th David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead CA, Sept 8-12, 2006. 419. Risheg H., Friez M .J., Graham. Jr. J.M ., Moeschler J.B., Rogers R.C., Opitz J.M ., Stevenson R.E., Schwartz C.E.: A novel missense mutation, p.R808W, in the HOPA gene is present in 10% of a cohort of FG syndrome families. American Journal of Human Genetics Abstract Book, Presented at the American Society of Human Genetics Meeting, New Orleans LA, October 9-13 2006. 420. Graham, Jr., J.M.: Diabetic embryopathy. UCSD Course in Human Teratology, La Jolla CA, October 28, 2006. 421. Graham, Jr., J.M ., Rock C., Robertson S., Krakow D.: Allelic disorders associated with mutations in filamin B (FLNB). Presented at the 12thManchester Birth Defects Conference, Manchester UK, November 21-24, 2006. 422. Risheg H., Friez M .J., Tarpey P., Raymond L., Turner G., Gecz J., Porteous M., Graham, Jr. J.M ., Opitz J.M ., Rogers R.C., Lubs H.A., Stevenson R.E., Schwartz C.E.: Lessons from Opitz FG syndrome and Lujan syndrome. Presented at the 12thManchester Birth Defects Conference, Manchester UK, November 21-24, 2006. 423. Borozdin W., Graham, Jr. J.M ., Bamshad M .J., Leipolldt J., Kohlhase J.: Characteristics of three overlapping microdeletions including SALL4 renders 5 neighboring genes responsible for severe developmental delay in a patient with Okihiro syndrome. Presented at the 12thManchester Birth Defects Conference, Manchester UK, November 21-24, 2006. 424. Graham, Jr. J.M.: Maternal diabetes and/or obesity during pregnancy as risk factors for birth defects during pregnancy. Invited Lecture for Research Institute, Ospedale Bambino Gesu, Rome Italy, November 28, 2006. 425. Graham, Jr., J.M.: CHARGE syndrome management: clinical and behavioral features. Invited Lecture for Research Institute, Ospedale Bambino Gesu, Rome Italy, November 28, 2006. Printed January 28, 2015 - Page 76 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 107 of 130 PAGEID #: E 424111 426. Graham, Jr., J.M.: Invited Speaker and Discussant: Descriptive terminology for the periocular region. NIH Consensus Conference on Dysmorphology Nomenclature, Rome IT, November 28 30, 2006. 427. Ballif BC, Hornor SA, Sulpizio SG, Lloyd RM, Minier SL, Rorem EA, Theisen A, Jenkin E, Madan-Khetarpal S, Surti U, Medne SU, Zackai E, Asamoah A, Farnsworth P, Gowans G, Conway RC, Graham' Jr JM, Bejjani BA, Shaffer LG; Discovery of a novel microdeletion syndrome on 16p11.2p12.2 and identification of other clinically relevant pericentromeric imbalances by array CGH. Platform presentation at the American College of Medical Genetics Meeting, Nashville TN, March 21-24, 2007. 428. Conway R.L., Pressman B., Dobyns B., Danielpouir M., Lee, J., Butler M .G., Zachai E., Close L . , Saitta S.C., Clericuzio C., Milunsky J., Hoyme G., Shieh J., Moeschler J.B., Crandall B., Lauzon J.L., Graham Jr., J.M.: Neuroimaging findings in macrocephaly-cutis marmorata telangiectatica congenital: a longitudinal study of 15 patients. Invited Talk. Festschrift for M Michael Cohen. Salt Lake City UT, March 31, 2007. 429. Graham, Jr., J.M ., Sanchez-Lara, P.A., Lee J., Hing A .V., Cunningham M.: The morphogenesis of wormian bones. Invited Talk. Festschrift for M Michael Cohen. Salt Lake City UT, March 31, 2007. 430. Ballif BC, Hornor SA, Jenkins E, Madan-Khetarpal S, Surti U, Jackson K, Asamoah A, Farnsworth P, Gowans G, Conway RL, Graham JM Jr, Medne L, Zackai E, Shaikh TH, Geoghegan J, Selzer R, Eis P, Bejjani BA, Shaffer LG: Discovery of clinically relevant pericentromeric imbalances using array-based comparative genomic hybridization. MC-GARD Molecular Profiling of the Genome Conference. Amsterdam, Netherlands. May 2-5, 2007. 431. Schwartz C.E., Tarpey P.S., Raymond L., Risheg H., Lubs H.A., Opitz J.M ., Clark R.D., May M. M., Briault S., Graham, Jr. J.M ., Fryns J.P., Piluso G., Chelly J., Verloes A., Skinner C., Rogers R.C., Moeschler J.B., Joseph S.M., Jones J., Gecz J., Raymond F.L., Stratton M., Friez M .J., Stevenson R.E.: Opitz-Kaveggia (FG) and Lujan syndromes are allelic having mutations in the MED12 gene. European Journal of Human Genetics, 15:Supplement 1, 267. Presented at the European Society of Human Genetics Meeting, Nice France, June 16-19, 2007. 432. Graham, JM Jr., Risheh H., Rogers R.C., Clark R.D., Jones K.L., Moeschler J.B., May M., Joseph S.M., Jones J.R., Schwartz C.E., Friez M .J., Stevenson R.E.: Clinical features in patients Clinical features in patients with Opitz-Kaveggia (FG) syndrome and a recurrent mutation, p.R961W, in the MED12 gene. European Journal of Human Genetics, 15:Supplement 1, 59. Presented at the European Society of Human Genetics Meeting, Nice France, June 16-19, 2007. 433. Lyons, M .J., Clark, R.D., Graham, J.M. Jr., Hunter, A.G.D., Neri, G., Rogers, R.C., Stevenson, R.E.: Clinical experience in the evaluation of 30 patients with a prior diagnosis of FG syndrome. Proceedings of the Greenwood Genetics Center, 27:102-103, 2007. Presented at the 28th David W. Smith Workshop on Malformations and Morphogenesis, Williamsburg VA, August 8-12, 2007. Printed January 28, 2015 - Page 77 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 108 of 130 PAGEID #: E 424121 434. Graham, J.M. Jr., Visootsak, J., Dykens, E., Clark, R.D., Jones, K.L., Moeschler, J.B., Rogers, R.C., Schwartz,, C.E., Friez, M .J., Stevenson, R.E.: Behavioral features in patients with OpitzKaveggia (FG) syndrome and a recurrent mutation, p.R961W, in the MED12 gene. Proceedings of the Greenwood Genetics Center, 27:101-102, 2007. Presented at the 28th David W. Smith Workshop on Malformations and Morphogenesis, Williamsburg VA, August 8-12, 2007. 435. Pober, B.R., Al-Gazali, L., Hill, R.S., Donnai, D., Black, G.C.M ., Bieth, E., Chassaing, N., Lacombe, D., Devriendt, K., Teebi, A., Lacassie, Y ., Graham, J.M. Jr., McPherson, E., Toriello, H., Loscertales, M., Robson, C., MacLaughlin, D.T., Noonan, K.M., Russell, M .K., Walsh, C.A., Donahoe, P.K., and Kantarci, S.: Mutations in megalin cause Donnai-Barrow Facio-OculoAcoustico-Renal syndrome. Proceedings of the Greenwood Genetics Center, 27:67-68, 2007. Presented at the 28th David W. Smith Workshop on Malformations and Morphogenesis, Williamsburg VA, August 8-12, 2007. 436. Sanchez-Lara, P.A., Graham, J.M. Jr., Lee, J., Hing, A.V., Cunningham, M.: Wormian bones in non-syndromic craniosynostosis. Proceedings of the Greenwood Genetics Center, 27:128, 2007. Presented at the 28th David W. Smith Workshop on Malformations and Morphogenesis, Williamsburg VA, August 8-12, 2007. 437. Clark, R.D., Graham, J.M. Jr., Stevenson, R.E., Rogers, R.C., Jones, K.L., Moeschler, J.B., Friez, M .J., Schwartz, C.E.: Opitz-Kaveggia (FG) syndrome revisited: the clinical phenotype in 10 affected males with the MED12 mutation R961W. Proceedings of the Greenwood Genetics Center, 27:100-101, 2007. Presented at the 28th David W. Smith Workshop on Malformations and Morphogenesis, Williamsburg VA, August 8-12, 2007. 438. Graham, J.M. Jr., Clark, R.D., Visootsak, J., Dykens, E., Jones, K.L., Moeschler, J.B., Rogers, R.C., Simenson, R, Schwartz,, C.E., Friez, M .J., Stevenson, R.E.: FG syndrome (OpitzKaveggia syndrome): clinical and behavioral phenotype in males with MED12 mutation, p.R961W. Genetic Counseling, in press, Presented at the 18thEuropean Meeting on Dysmorphology, Strasbourg, FR, September 5-7, 2007. 439. Graham, J.M ., Jr.: Invited presentation: Differential diagnosis: generalized overgrowth disorders. 1st Course in Clinical Dysmorphology, European School of Genetic Medicine, Bologna IT, September 9-12, 2007. 440. Graham, J.M ., Jr.: Invited presentation: Differential diagnosis: generalized overgrowth disorders. 1st Course in Clinical Dysmorphology, European School of Genetic Medicine, Bologna IT, September 9-12, 2007. 441. Graham, J.M ., Jr.: Invited presentation: Dysmorphic features of the skull and face, 1st Course in Clinical Dysmorphology, European School of Genetic Medicine, Bologna IT, September 9-12, 2007. 442. Graham, J.M ., Jr.: Invited presentation: Dysmorphic features of the trunk and limbs, 1st Course in Clinical Dysmorphology, European School of Genetic Medicine, Bologna IT, September 9-12, 2007. Printed January 28, 2015 - Page 78 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 109 of 130 PAGEID #: E424131 443. Graham, J.M ., Jr.: Invited presentation: Deformations and deformation patterns, 1st Course in Clinical Dysmorphology, European School of Genetic Medicine, Bologna IT, September 9-12, 2007. 444. Graham, J.M ., Jr.: Invited presentation: Disruptions and disruptive patterns, 1st Course in Clinical Dysmorphology, European School of Genetic Medicine, Bologna IT, September 9-12, 2007. 445. Graham, J.M. Jr., Clark, R.D., Visootsak, J., Dykens, E., Jones, K.L., Moeschler, J.B., Rogers, R.C., Simenson, R, Schwartz,, C.E., Friez, M .J., Stevenson, R.E.: FG syndrome (OpitzKaveggia syndrome): clinical and behavioral phenotype in males with MED12 mutation, p.R961W. Genetic Counseling, in press, Presented at the 13thInternational Meeting on Fragile X and Mental Retardation, Venice, IT, October 3-6, 2007. 446. Graham, J.M ., Jr.; Invited Talk: Pierre Robin Sequence. Children's Hospital of Orange County Craniofacial Symposium. Orange CA, October 13, 2007. 447. Graham, J.M. Jr., Visootsak, J., Dykens, E., Clark, R.D., Jones, K.L., Moeschler, J.B., Rogers, R.C., Schwartz,, C.E., Friez, M .J., Stevenson, R.E.: Behavioral features in patients with FG (Opitz-Kaveggia) syndrome and a recurrent mutation, p.R961W, in the MED12 gene. American Society of Human Genetics Abstract Book p156, Presented at the American Society of Human Genetics Meeting, San Diego CA, October 23-27, 2007. 448. Sanchez-Lara, P.A., Graham, J.M. Jr., Lee, J., Hing, A.V., Cunningham, M.: The morphogenesis of wormian bones: a study of craniosynostosis and purposeful cranial deformation. American Society of Human Genetics Abstract Book p149, Presented at the American Society of Human Genetics Meeting, San Diego CA, October 23-27, 2007. 449. Conway R.L., Pressman B., Dobyns B., Butler M .G., Zachai E., Saitta S.C., Campbell, L., Clericuzio C., Milunsky J., Hoyme G., Shieh J., Moeschler J.B., Crandall B., Lauzon J.L., Visckochil D., Harding B., Graham Jr., J.M.: Neuroimaging findings in macrocephaly-cutis marmorata telangiectatica congenital. American Society of Human Genetics Abstract Book p138, Presented at the American Society of Human Genetics Meeting, San Diego CA, October 23-27, 2007. 450. Carr C.W., Zhang J., Carron J.D., Lachman R.S., Graham, J.M ., Jr., Kramer N.A., AbdulRahman O.A.: Van Den Ende Gupta syndrome: expansion of the phenotype and confirmation of autosomal recessive inheritance. American Society of Human Genetics Abstract Book p147, Presented at the American Society of Human Genetics Meeting, San Diego CA, October 23-27, 2007. 451. Clark R.D., Graham J.M ., Jr., Stevenson R.E., Rogers R.C., Jones K.L., Moeschler J.B. Friez M .J., Schwartz C.E.: Opitz-Kaveggia (FG) syndrome revisited: the clinical phenotype in 10 affected males with MED12 mutation R961W. American Society of Human Genetics Abstract Book p158, Presented at the American Society of Human Genetics Meeting, San Diego CA, October 23-27, 2007. Printed January 28, 2015 - Page 79 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 110 of 130 PAGEID #: E424141 452. Bernstein J.A., Alkuraya, F.S., Armstrong L., Chen K .C., Clericuzio C., Graham J.M ., Jr., Stoler J., Saal H.M., Stevens C.A., Cherry A.M., Hoyme H.E.: Duplication 22q11.2: clinically heterogeneous new syndrome or genetic polymorphism? American Society of Human Genetics Abstract Book p170, Presented at the American Society of Human Genetics Meeting, San Diego CA, October 23-27, 2007. 453. Graham J.M ., Jr. Invited Lecture: Craniofacial malformations, deformations disruptions and dysplasias. Indian Academy of Pediatrics Course on Genetics for the Practicing Pediatrician. New Delhi, India. December 16-16, 2007. 454. Graham J.M ., Jr. Invited Lecture: Common malformation syndromes in pediatric practice. Indian Academy of Pediatrics Course on Genetics for the Practicing Pediatrician. New Delhi, India. December 16-16, 2007. 455. Graham J.M ., Jr. Invited Lecture: Congenital overgrowth syndromes. Indian Academy of Pediatrics Course on Genetics for the Practicing Pediatrician. New Delhi, India. December 16 16, 2007. 456. Graham J.M ., Jr., Visootsak J., Dykens E., Clark R.D., Jones, K.L., Moeschler J.B., Rogers R.C., Schwartz C.E.,Friez M .J., Stevenson R.E.: Clinical and behavioral features in patients with FG (Opitz-Kaveggia) syndrome and a recurrent mutation, p.R961W, in the MED12 gene. American College of Medical Genetics Annual Meeting, Phoenix AZ, March 12-16, 2008. 457. Graham J.M ., Jr. Invited Lecture: Larsen Syndrome. Second European Course in Clinical Dysmorphology. Rome, Italy. March 28-29, 2008. 458. Adam, M.P., Hudgins L., Carey, J.C ., Hall, B.D., Coleman K., Gripp K.W., Perez-Aytes A., Graham, Jr., J.M.: Invited Presentation. Preaxial hallucal polydactyly as a marker for diabetic embryopathy. Lewis B. Holmes Festschrift, Boston MA, May 10, 2008. 459. Graham J.M ., Jr. Course Organizer, Invited Presentation: Dysmorphic features of the face and skull. Second European School of Medical Genetics Course in Clinical Dysmorphology. Bertinoro, Italy May 12-15, 2008. 460. Graham J.M ., Jr. Course Organizer, Invited Presentation: Teratogenic effects of maternal diabetes and/or obesity. Second European School of Medical Genetics Course in Clinical Dysmorphology. Bertinoro, Italy May 12-15, 2008. 461. Graham J.M ., Jr. Course Organizer, Invited Presentation: Fetal alcohol syndrome. Second European School of Medical Genetics Course in Clinical Dysmorphology. Bertinoro, Italy May 12-15, 2008. 462. Graham J.M ., Jr. Course Organizer, Invited Presentation: Effects of antidepressant drugs and cigarettes during pregnancy. Second European School of Medical Genetics Course in Clinical Dysmorphology. Bertinoro, Italy May 12-15, 2008. Printed January 28, 2015 - Page 80 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 111 of 130 PAGEID #: E424151 463. Graham J.M ., Jr. Course Organizer, Invited Presentation: Disruptions and disruptive effects. Second European School of Medical Genetics Course in Clinical Dysmorphology. Bertinoro, Italy May 12-15, 2008. 464. Graham J.M ., Jr. Course Organizer, Invited Presentation: Teratogenicity of retinoids and immunosuppressants. Second European School of Medical Genetics Course in Clinical Dysmorphology. Bertinoro, Italy May 12-15, 2008. 465. Graham J.M ., Jr. Invited Presentation: Teratogenic effects of maternal diabetes and/or obesity. Perinatal Advisory Committee of Los Angeles County (PAC-LAC) Annual Conference. Los Angeles CA, May 29, 2008. 466. Graham J.M ., Jr. Invited Presentation: Review of array comparative genomic hybridization in the evaluation of autism. Signature Scientific Microarray Conference. Spokane WA, June 20-21, 2008. 467. Graham J.M ., Jr., Kramer, N., Bejjani, B., Thiel, C.T., Carta, C., Neri, G,Tartagli,a M., Zenker, M: Duplication of PTPN11 in a boy with Noonan syndrome. Signature Scientific Microarray Conference. Spokane WA, June 20-21, 2008. 468. Graham, Jr., J.M ., Adam, M.P., Hudgins L., Carey, J.C., Hall, B.D., Coleman K., Gripp K.W., Perez-Aytes A.: Preaxial hallucal polydactyly as a marker for diabetic embryopathy. Presented at the Teratology Society Meeting, Monterey CA, June 29-July 2, 2008. 469. Sanchez-Lara, PA, Carmichael, S., Graham, jM. Jr. Lammer, E, Shaw, G, Rasmussen, S.A. and the National Birth Defects Prevention Study: Fetal constraint as a potential risk factor for craniosynostosis: Presented at the Teratology Society Meeting, Monterey CA, June 29-July 2, 2008. 470. Graham J.M ., Jr., Kramer, N., Bejjani, B., Thiel, C.T., Carta, C., Neri, G, Tartaglia M., Zenker, M: Duplication of PTPN11 in a boy with Noonan syndrome. Presented at the 29th David W. Smith Workshop on Malformations and Morphogenesis, Mont Tremblanc, Quebec, Canada, August 8-12, 2008. 471. Adam, M.P., Hudgins L., Carey, J.C ., Hall, B.D., Coleman K., Gripp K.W., Perez-Aytes A., Graham, Jr., J.M.: Preaxial hallucal polydactyly as a marker for diabetic embryopathy. Presented at the 29th David W. Smith Workshop on Malformations and Morphogenesis, Mont Tremblanc, Quebec, Canada, August 8-12, 2008. 472. Sanchez-Lara, PA, Carmichael, S., Graham, jM. Jr. Lammer, E, Shaw, G, Rasmussen, S.A. and the National Birth Defects Prevention Study: Fetal constraint as a potential risk factor for craniosynostosis. Presented at the 29th David W. Smith Workshop on Malformations and Morphogenesis, Mont Tremblanc, Quebec, Canada, August 8-12, 2008. Printed January 28, 2015 - Page 81 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 112 of 130 PAGEID #: E424161 473. Spencer, A., Lara- Sanchez, P. Dobyns, W., Golden, J., Schwartz, C., Bannykh, S, Krakow, D. Graham, J.M ., Jr.: An unusual case of lissencephaly with distinctive neuropathology: a new syndrome compared with other known lissencephaly syndromes. Presented at the 29th David W. Smith Workshop on Malformations and Morphogenesis, Mont Tremblanc, Quebec, Canada, August 8-12, 2008. 474. Graham J.M ., Jr., Kramer, N., Bejjani, B., Thiel, C.T., Carta, C., Neri, G, Tartaglia M., Zenker, M: Duplication of PTPN11 in a boy with Noonan syndrome. Presented at the 13th Manchester Dysmorphology Conference, Manchester England, October 28-61, 2008. 475. Sanchez-Lara, PA, Carmichael, S., Graham, jM. Jr. Lammer, E, Shaw, G, Rasmussen, S.A. and the National Birth Defects Prevention Study: Fetal constraint as a potential risk factor for craniosynostosis. Presented at the American Society of Human Genetics Meeting, Philadelphia, PA, November 11-15, 2008. 476. Graham J.M ., Jr. Invited Presenation: Teratogenic impact of maternal gestational diabetes. 15th Annual Conference: California Association of Neonatologists: Current Topics and Controversies in Perinatal and Neonatal Medicine. Coronado CA, March 6-8, 2009. 477. Spencer A, Pariani M, Graham J.M ., Jr., Rimoin D: Deletion of FOXP1 is associated with speech delay, contractures, hypertonia and blepharophimosis. Presented at the American College of Medical Genetics Meeting. Abstract 232; page 155. Tampa FL, March 25-28, 2009. 478. Graham J.M ., Jr. Invited Presentation: Uterine and Placental Factors. Massachusetts General Hospital Postgraduate Course in Human Teratogens. Boston MA, April 26-28, 2009. 479. Graham, J.M ., Jr.: Invited Presentation: Medical genetics evaluation in children with disabilities: why does it matter? Spring Medical Surgical /Behavioral Science Conference, Bad Kissingen, Germany, May 17-21, 2009. 480. Graham, J.M ., Jr.: Invited Presentation: Diagnosis-based management of children (and families) with genetic syndromes. Spring Medical Surgical /Behavioral Science Conference, Bad Kissingen, Germany, May 17-21, 2009. 481. Graham J.M ., Jr., Merrill A., Krakow D.: Is use of the term autosomal recessive Larsen syndrome justified for autosomal recessive sulfation disorders? Presented at the 30th David W. Smith Workshop on Malformations and Morphogenesis, Children's Hospital of Philadelphia, Philadelphia PA, August 5-9, 2009. 482. Mencias I., Kohlhase J., Borozdin W., Graham J.M ., Jr.: Wildervanck syndrome: an asymmetrical phenotype with discordant expression in monozygous twins. Presented at the 30th David W. Smith Workshop on Malformations and Morphogenesis, Children's Hospital of Philadelphia, Philadelphia PA, August 5-9, 2009. Printed January 28, 2015 - Page 82 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 113 of 130 PAGEID #: E 424171 483. Spencer A., Grinberg I., van Ruissen F., Namavar Y., Baas F., Plat L., Dobyns W., Graham J.M., Jr.: Pontocerebellar hypoplasia type II in twins caused by a homozygous mutayion in TSEN54: Is prenatal diagnosis possible? Presented at the 30th David W. Smith Workshop on Malformations and Morphogenesis, Children's Hospital of Philadelphia, Philadelphia PA, August 5-9, 2009. 484. Clark, R.D., Graham, Jr., J.M ., Friez M .J., Hoo, J.J., Jones, K.L., McKeown C., Moeschler, J.B., Raymond F.L., Rogers, R.C., Schwartz, C.E., Battaglia A., Lyons M .J., Stevenson, R.E.: The clinical phenotype of FG (Opitz-Kaveggia): an algorithm for diagnostic testing. Presented at the British Society of Human Genetics Conference, University of Warwick, Coventry UK, August 31-September 2, 2009. 485. Graham, J.M ., Jr.: Invited Presentation: Common syndromic prenatal-onset growth disorders. Landstuhl Regional Medical Center Grand Rounds, Heidelberg, Germany, September 1, 2009. 486. Graham J.M ., Jr., Spencer A., Grinberg I., Platt L., Maya M., van Ruissen F., Namavar Y ., Baas F., Platt L., Dobyns W.: Molecular and neuroimaging findings in pontocerebellar hypoplasia type II. Platform presention at the 20th European Meeting on Dysmorphology, Strasbourg France, September 4-5, 2009. 487. Clark, R.D., Graham, Jr., J.M ., Friez M .J., Hoo, J.J., Jones, K.L., McKeown C., Moeschler, J.B., Raymond F.L., Rogers, R.C., Schwartz, C.E., Battaglia A., Lyons M .J., Stevenson, R.E.: The clinical phenotype of FG syndrome: an algorithm for diagnostic testing. Platform presentation at the American Society of Human Genetics Meeting, Abstract 228, page 87, Honolulu, HI, October 20-24, 2009. 488. Burkardt D., Rosenfeld J., Angle B., Banks V., Gripp K.W., Helgeson M., Kramer N., Moline J., Moran R., Niyazov D.M., Smith W., Stevens C., Zackai E., Lachman R.S., Graham, J.M. Jr.: Patients with deletion 1q24-q25 have a recognizable syndrome. Platform presention at the American College of Medical Genetics Meeting, Albuquerque NM, March 24-28, 2010. 489. Burkardt D., Rosenfeld J., Angle B., Banks V., Gripp K.W., Helgeson M., Kramer N., Moline J., Moran R., Niyazov D.M., Smith W., Stevens C., Zackai E., Lachman R.S., Graham, J.M. Jr.: Distinctive phenotype in 8 patients with deletion of chromosome 1q24-q25. Platform presention at the Pediatric Academic Societies Meeting, Vancouver BC, May 1-4, 2010. 490. Sun A, Petrin AL, May M, Chaubrey A, Murray JC, Smith RJH, Schwartz CE, Kramer N, Graham, Jr JM: A new gene for Branchio-Oto-Renal syndrome in an extended pedigree: AHI1. Presented at the 31th David W. Smith Workshop on Malformations and Morphogenesis, Alderbrrook Resort, Union WA, August 27-September 1, 2010. 491. Graham, J.M. Jr.'Burkardt D., Rosenfeld J., Helgeson M., Angle B., Banks V., Smith W., Gripp K.W., Moline J., Moran R., Niyazov D.M., Stevens C., Zackai E., Lebel R.R., Ashley D., Kramer N., Lachman R .S.:Distinctive phenotype in 9 patients with deletion of chromosome 1q24-q25. Presented at the 31th David W. Smith Workshop on Malformations and Morphogenesis, Alderbrrook Resort, Union WA, August 27-September 1, 2010. Printed January 28, 2015 - Page 83 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 114 of 130 PAGEID #: E424181 492. Graham, J.M. Jr.'Burkardt D., Rosenfeld J., Helgeson M., Angle B., Banks V., Smith W., Gripp K.W., Moline J., Moran R., Niyazov D.M., Stevens C., Zackai E., Lebel R.R., Ashley D., Kramer N., Lachman R .S.:Distinctive phenotype in 9 patients with deletion of chromosome 1q24-q25. Presented at the 14th Manchester Dysmorphology Conference, Manchester England, October 11-14, 2010. 493. Noh G Y, Graham, J.M. Jr.: Elucidating the complexity of epilepsy: clues from 2q23.1 deletion. Journal of Investigative Medicine 59; 111, 2011. Presented at the Western Society for Pediatric Research Meeting, Carmel, CA, January 26-29, 2011. 494. Graham, J.M. Jr.: Invited presentation: Common limb malformation syndromes, First Indo-US Symposium on Skeletal Dysplasia, Lucknow, India, Febuary 12-13, 2011. 495. Graham, J.M. Jr.: Invited presentation: Overgrowth syndromes, First Indo-US Symposium on Skeletal Dysplasia, Lucknow, India, Febuary 12-13, 2011. 496. Graham, J.M. Jr.: Cardinal features and characteristicbehaviors in FG syndrome. Invited Presentation, A CM G Program Guide and Abstracts p.277, Presented at the American College of Medical Genetics Annual Meeting, Vancouver BC, March 16-20, 2011. 497. Graham, J.M. Jr., Kramer N., Funari V., Klein O., Seidel K., Kantaputra P., Taylor K.D.: Autosomal dominant natal teeth with selective tooth agenesis. ACM G Program Guide and Abstracts p.228, Presented at the American College of Medical Genetics Annual Meeting, Vancouver BC, March 16-20, 2011. 498. Noh G Y, Graham, J.M. Jr.: Elucidating the complexity of epilepsy: clues from 2q23.1 deletion. A CM G Program Guide and Abstracts p.197, Presented at the American College of Medical Genetics Annual Meeting, Vancouver BC, March 16-20, 2011. 499. Graham, J.M. Jr., Kramer N., Funari V., Klein O., Seidel K., Kantaputra P., Taylor K.D.: Autosomal dominant natal teeth with selective tooth agenesis. Presented at European Society for Human Genetics Annual Meeting, Amsterdam, Netherlands May 28-31, 2011. 500. Klaassens M., Reinstein E., Hilhorst-Hofstee Y., Schrander J.J.P., Malfait F., Staal H., Speth L., ten Have L.C., Blaauw J., Roggeveen H .C.J., De Paepe A., van Steensel M .A.M., Pals G., Graham, Jr., J.M ., Schrander-Stumpel C.T.R.M.: Ehlers-Danlos syndrome arthrochalasia type (VIIA-B) - expanding the phenotype: from prenatal life through adulthood. Presented at European Society for Human Genetics Annual Meeting, Amsterdam, Netherlands May 28-31, 2011. 501. Graham, J.M. Jr., Kramer N., Funari V., Klein O., Seidel K., Kantaputra P., Taylor K.D.: Autosomal dominant natal teeth with selective tooth agenesis. Presented at the 32nd David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead UCLA Conference Center, Lake Arrowhead CA, September 9-14, 2011. Printed January 28, 2015 - Page 84 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 115 of 130 PAGEID #: E424191 502. Dobyns W.B., Mirzaa G.M., Graham, J.M. Jr.: Insights on overgrowth from the macrocephalycapillary malformation syndrome. Presented at the 32nd David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead U CLA Conference Center, Lake Arrowhead CA, September 9-14, 2011. 503. Sun A., Taylor K., Kramer N., Graham, J. M., Jr.: Novel locus identified for Branchio-Oto-Renal syndrome. Presented at the 32nd David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead U CLA Conference Center, Lake Arrowhead CA, September 9 14, 2011. 504. Reinstein E., Graham J.M. Jr., Rimoin D.L.: Ehlers-Danlos syndrome with periventricular nodular heterotopia (EDS-PNH): expanding the phenotype. Presented at the 32nd David W. Smith Workshop on Malformations and Morphogenesis, Lake Arrowhead UCLA Conference Center, Lake Arrowhead CA, September 9-14, 2011. 505. Graham, J.M. Jr., Kramer N., Funari V., Klein O., Seidel K., Kantaputra P., Taylor K.D.: Autosomal dominant natal teeth with selective tooth agenesis. Presented at 34thAnnual Society of Craniofacial Genetics and Developmental Biology Meeting, Montreal, October 11, 2011, American Journal of Medical Genetics, Part A, p4, 2012. 506. Graham, J.M. Jr., Kramer N., Funari V., Klein O., Seidel K., Kantaputra P., Taylor K.D.: Autosomal dominant natal teeth with selective tooth agenesis. Presented at 12thInternational Congress of Human Genetics, Montreal, October 11-15, 2011. 507. Sun A., Taylor K., Kramer N., Graham, J.M. Jr.: Novel locus identified for Branchio-Oto-Renal syndrome. Presented at 12thInternational Congress of Human Genetics, Montreal, October 11 15, 2011. 508. Lee H., Graham J.M. Jr., Rimoin D.L., Lachman R.S., Nelson S.F., Krakow D., Cohn D.H.: Acrodysostosis: exome sequencing identifies mutations in PDE4D encoding phosphodiesterase 4D. Presented at 12thInternational Congress of Human Genetics, Montreal, October 11-15, 2011. 509. Stevens C.G., Yagnik G. Qi L. Cherkez E., Sanchez-Lara P.A., Kimonis V., Stoler J., Cunningham M., Graham J.M. Jr., Boyadiev S.A.: Clinical and epidemiolocal analysis of nonsyndromic craniosynostosis. Presented at 12thInternational Congress of Human Genetics, Montreal, October 11-15, 2011. 510. Noh G Y, Graham, J.M. Jr.: Elucidating the complexity of epilepsy: clues from 2q23.1 deletion. Presented at 12thInternational Congress of Human Genetics, Montreal, October 11-15, 2011. 511. Probst F.J., Corrigan R.R., Zabriskie R.C., Murdock D.R., Hamid R., Tiller G.E., Phillips J.A., Kramer N., Graham J.M. Jr., Bainbridge M.N., jin W., Wang L.L., Gibbs R.A., Plon S.E.: Linkage analysis and whole-exome sequencing on families with multiple lipomatosis. Presented at 12thInternational Congress of Human Genetics, Montreal, October 11-15, 2011. Printed January 28, 2015 - Page 85 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 116 of 130 PAGEID #: E424201 512. O 'Leary R., Shih J.C., Hyland K., Kawamata N., Tavyev-Asher Y. J., Graham J. M., Jr.: De novo microdeletion ofXp11.3 targeting the monoamine oxidase A and B genes in a male infant with episodic hypotonia: a genomics approach to personalized medicine. Presented at Western Society for Pediatric Research, Carmel CA, January 26-28, 2012 (Winner WSPR Genetics Subspecialty Award). 513. Kramer N.A., Falk R.E., Graham J.M ., Jr.: Evidence of a population specific mutation in USH1G that leads to Usher syndrome in the Filipino population. Presented at American College of Medical Genetics Annual Meeting, Charlotte NC, March 27-31, 2012. 514. Graham J.M ., Jr., O 'Leary R., Shih J.C., Hyland K., Kawamata N., Tavyev-Asher Y. J.: De novo microdeletion ofXp11.3 targeting the monoamine oxidase A and B genes in a male infant with episodic hypotonia. Presented at the 33rd David W. Smith Workshop on Malformations and Morphogenesis, Legacy Lodge Conference Center, Atlanta GA, August 8-12, 2012. 515. Carter M.T., Mirzaa G.M., McDonell L.M., Clericuzio C., Aesadi G., Graham, J.M ., Jr., Dobyns W.B., Boycott K.M.: Microcephaly-Capillary Malformation Syndrome (MIC-CAP): further clinical delineation of four new patients. Presented at the 33rd David W. Smith Workshop on Malformations and Morphogenesis, Legacy Lodge Conference Center, Atlanta GA, August 8-12, 2012. 516. Graham J.M ., Jr.: Invited Talk: Genetics of neonatal seizures and early infantile epileptic encephalopathy. Presented at Indo-US Symposium on Disorders in the developing Brain. October 27-28, 2012, Kasturba Medical College, Manipal India. 517. Graham J.M ., Jr.: Evaluation of epilepsy syndromes in Genetics clinic. Presented at Indo-US Symposium on Disorders in the developing Brain. October 27-28, 2012, Kasturba Medical College, Manipal India. 518. Basel-Vanagaite L., Kasrlinsky L., Wolf L., Shohat M., Skinner C., Rogers C., Stevenson R., Schwartz C.E., Graham J.M ., Jr.,: Computer-aided facial recognition of individuals with FG (Opitz-Kaveggia) syndrome caused by p.Arg961Trp mutation in MED12, Presented at American Society of Human Genetics Meeting, November 6-10, 2012. 519. Russell B, Nasiak M, Kramer N, Johnston JJ, Biesecker LG, Graham JM Jr.: Diagnosis and management of Bohring-Opitz Syndrome caused by de novo ASXL1 mutations. Presented at Western Society for Pediatric Research, Carmel CA, January 24-26, 2013. 520. Bale S., Graham Jr., J.M ., Cohen J., Kramer N.: Laboratory and Clinical Perspectives on the Technology and Applications of Whole Exome Sequencing. National Society of Genetic Counselors Webinar, March 28, 2013. 521. Graham Jr. JM, Russell B, Johnston JJ, Biesecker LG: Diagnosis and management of Bohring Opitz Syndrome with or without ASXL1 mutations. Presented at the European Human Conference, Paris FR, June 8-11, 2013. 522. Graham Jr, JM. Pediatric issues in Marfan syndrome. National Marfan Foundation Annual Family Conference, Los Angeles CA, August 3, 2013. Printed January 28, 2015 - Page 86 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 117 of 130 PAGEID #: E 424211 523. Mirzaa G.H., Adams C, Kramer N, Conway R.L., Graham, Jr. J.M ., Dobyns W.B.: Molecular insights into mosaic megalencephaly disorders. Presented at the 34th David W. Smith Workshop on Malformations and Morphogenesis, Mont Tremblant, Quebec, CA, August 9-14, 2013. 524. Graham, Jr., J.M ., Russell B., Kramer N., Johnston J.J., Biesecker L.G.: Diagnosis and management of Bohring-Opitz syndrome. Presented at the 34th David W. Smith Workshop on Malformations and Morphogenesis, Mont Tremblant, Quebec, CA, August 9-14, 2013. 525. Hunter AGW, Graham, Jr., JM, Neri G, Rogers RC, Stevenson RE, Turner G, Friez MJ: The Intellectual Disabilities Evaluation and Advice System (IDEAS): outcome of the first 55 cases. Presented at the 34th David W. Smith Workshop on Malformations and Morphogenesis, Mont Tremblant, Quebec, CA, August 9-14, 2013. 526. Castillo A., Kramer N., Lausch E., Zachai, EH, Hakonsrson H, Saita S, Graham Jr. J.M.: Infantile systemic hyalinosis versus infantile myofibromatosis. Presented at the 34th David W. Smith Workshop on Malformations and Morphogenesis, Mont Tremblant, Quebec, CA, August 9-14, 2013. 527. Mirzaa GM, Adams C, Kramer N, Conway R, Graham, Jr. JM, Dobyns WB: Molecular insights into mosaic megalencephaly disorders. Presented at the 34th David W. Smith Workshop on Malformations and Morphogenesis, Mont Tremblant, Quebec, CA, August 9-14, 2013. 528. McDonnell LM, Mirzza GH, Alcantara D, Carter Melissa T, Graham, J. JM, Dobyns WB, O 'Driscoll M, Boycott KM: Mutations in STAMBB cause microcephaly capillary malformation syndrome. Presented at the 34th David W. Smith Workshop on Malformations and Morphogenesis, Mont Tremblant, Quebec, CA, August 9-14, 2013. 529. McMillan M J, Beck AE, Chong JX , Shively KM, Buckingham KJ, Gildersleeve HJ, Splitt M, Aylesworth AS, Krapels IPC, Curry CJ, Alvarez MIA, Hecht JT, Hurst J, Scott R, Graham, Jr JM, Smith JD, Tabor HK, Shendure J, Nickerson DA, Banshad MJ: Mutations in PIEZO2 cause Gordon syndrome, Marden Walker syndrome and distal arthrogryposis type 5. Presented at the American Society of Human Genetics Meeting, Boston MA, October 22-26, 2013. 530. Dhamija R, Graham, Jr, JM, Thorland E, Kirmani S: Novel denovo SPOCK1 mutation in a proband with developmental delay, microcephaly and agenesis of corpus callosum. Presented at the American Society of Human Genetics Meeting, Boston MA, October 22-26, 2013. 531. Graham, Jr. JM: Lessons from the exome. Pediatric Grand Rounds, Dartmouth-Hitchock Medical Center, Lebanon NH, October 2, 2013. 532. Shih EM, Graham, Jr. JM, Vitazka P, Pitukcheewanont P: Duplication of 17p13.3 involving SERPINF1 associated with an unclassified type of metaphyseal dysplasia. Presented at Western Society for Pediatric Research, Carmel CA, January 24, 2014, Journal of Investigative Medicine, 62:232, 2014. 533. Graham, Jr. JM: Lessons from the exome. Pediatric Grand Rounds, Harbor-UCLA Medical Center, Torrance CA, February 13, 2014. Printed January 28, 2015 - Page 87 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 118 of 130 PAGEID #: E 424221 534. Graham Jr. JM: The many faces of hemimegalencephaly. Invited Presentation. Scientific Workshop on Brain Plasticity, Hemisheric Specialization, and Neurorehabilitation After Cerebral Hemisherectomy, Paradise Pier Hotel, Anaheim CA, July 9-12, 2014. 535. Graham Jr., JM, McMillin M J, Chong J, Beck A, Bamshad M: Long-term follow-up of a patient with Msarden-Walker syndrome and a c.8056C>T PIEZO2 mutation and comparison with Gordon syndrome and c.8057G>A mutations in PIEZO2. Presented at the 35th David W. Smith Workshop on Malformations and Morphogenesis, Madison WI, July 25-30, 2014. 536. Tenney J, Graham Jr, JM, Dobyns WB, Gleeson JG: A male with preaxial polydactyly, Joubert syndrome and OFD1 mutation discovered by exome sequencing. Presented at the 35th David W. Smith Workshop on Malformations and Morphogenesis, Madison WI, July 25-30, 2014. 537. Babkina N, Giurgea I, Mowat D, Graham Jr. JM: Early infantile epileptic encephalopathy with a de novo variant in ZEB2 discovered by exome sequencing. Presented at the 35th David W. Smith Workshop on Malformations and Morphogenesis, Madison WI, July 25-30, 2014. 538. Russell B, Johnston JJ, Biesecker LG, Kramer N, Pickart A, Rhead W, Tan W-H, Brownstein CA, Clarkson LK, Dobson A, Rosenberg AZ, Graham Jr., JM: Clinical management of patients with ASXL1 mutations and Bohring-Opitz Syndrome, emphasizing the need for Wilms tumor surveillance. Presented at the 64thAnnual American Society for Human Genetics Meeting, October 18-22, 2014, San Diego CA. 539. Graham Jr, JM: Everything you needed to know about plagiocephaly and craniosynostosis but were afraid to ask. (Invited Presentation). AAP Chapter 2 Town Hall Meeting, October 22, 2014, Woodland Hills CA. 540. Graham Jr, JM: Congenital overgrowth syndromes. (Invited Presentation). Presented at the INDO-US Symposium on Genomic Insights into Human Morphogenesis: Prenatal, Postnatal and Molecular Dysmorphology & First Annual Meeting of the Indian Academy of Medical Genetics, November 7-9, 2014, Hyderabad, India. 541. Graham Jr, JM: MED-12 Related Disorders. (Invited Presentation). Presented at the INDO-US Symposium on Genomic Insights into Human Morphogenesis: Prenatal, Postnatal and Molecular Dysmorphology & First Annual Meeting of the Indian Academy of Medical Genetics, November 7-9, 2014, Hyderabad, India. 542. Graham Jr., JM: Syndromes of Primordial Short Stature. (Invited Presentation). Presented at the INDO-US Symposium on Genomic Insights into Human Morphogenesis: Prenatal, Postnatal and Molecular Dysmorphology & First Annual Meeting of the Indian Academy of Medical Genetics, November 7-9, 2014, Hyderabad, India. 543. Graham Jr, JM: Infant head shape abnormalities. (Invited Presentation). CSMC Pediatric Grand Rounds, January 15, 2015, Los Angeles, CA. Printed January 28, 2015 - Page 88 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 119 of 130 PAGEID #: E424231 Appenaix B 3 EXPERT TESTIMONY (2010-2014) John M. Graham, Jr., MD, ScD Jackson v. Wyeth et al (Cloacal malformation) Court Testimony 12/6/10 For: Kathy A. Cochran, Esq. (Defense), Wilson, Smith, Cochran, Dickerson 1215 Fourth Ave.,, Suite 1700, Seattle WA 98161 Davis v. Totally Kids (Central Hypoventilation syndrome-PHOX2B) Deposition Testimony 6/10/11 For: George Nowotny, Esq. (Defense) Lewis Brisbois Bisgaard & Smith LLP 221 N. Figueroa St., Suite 1200, Los Angeles, CA 90012 Anderson v. Village Covenant Church (Epileptic Encephalopathy) Deposition Testimony (1/30/12) For: Bill Daniels Esq. (Treating Geneticist) Bill Daniels Law Offices, APC 16133 Ventura Blvd, Penthouse Suite A, Encino CA 91436 Whitney v. Hadco Corp. (Hirschsprung disease with CMV infection) Deposition Testimony 3/5/12 For: Sean Joanis Esq. (Defense) Bonner, Kiernan, Trebach and Crociata LLP 200 Portland Street, 4th Floor, Boston MA 02114 Czimmer, Bennett, Powell, Anderson, Ramos et al., v. Janssen Pharmaceuticals (Topamax Product Liability) Depositons 4/8/13, 4/9/13, 6/18/13, 7/2/13, 12/3/13 For: Bill Essig Esq. (Defense) Drinker Biddle and Reath LLP 191 North Wacker Dr, Suite 3700, Chicago IL 60606 Zoloft Product Liability Litigation (Pfizer, Inc) Deposition 11/25/13 For: Andrew Myer, Esq. (Defense) Wheeler, Trigg, ODonnell, LLP 1801 California Street, Suite 3600, Denver CO 80202 Bonner v. Abbott (Depakote Product Liability) Deposition 3/14/14 For: Michael Klatt, Esq. (Defense) Gordon & Rees LLP 816 Congress Avenue, Suite 1510, Austin, TX 78701 1 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 120 of 130 PAGEID #: E424241 Murphy v. NXP Semiconductors (Paternally derived NKX2.2 disruption) Deposition 3/18/14 For: Daniel L. Ring, Esq. (Defense) Mayer Brown LLP 71 South Wacker Drive Chicago, Illinois 60606 Dotegowski v Abbott Laboratories (Depakote Product Liability) Deposition 7/8/14 For: Michael Klatt, Esq. (Defense) Gordon & Rees l Lp 816 Congress Avenue, Suite 1510, Austin, TX 78701 Bustamante v. Children's Hospital of Los Angeles (22q11.2 del-IAA) Deposition 8/8/14 For: Alex Watson, Esq. (Defense) Fraser, Watson & Croutch LLP 100 West Broadway, Suite 650, Glendale, CA 91210 Kaleta v Abbott Laboratories (Depakote Product Liability) Deposition 12/9/14 For: Michael Klatt, Esq. (Defense) Gordon & Rees LLP 816 Congress Avenue, Suite 1510, Austin, TX 78701 2 Case: 2:13-md-02433-EAS-EPD Doc #: 2807-2 Filed: 04/06/15 Page: 121 of 130 PAGEID #: E424251 Appendix C Materials Considered C-8 Science Panel, Probable Link Evaluation of Birth Defects (Dec. 5, 2011). First Amended Complaint in Bartlett v. E. I. du Pont de Nemours and Company, Case No. 2:13-cv-170 (S.D. Ohio). Complaint in Wolfv. E. 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