Document o9b4yRyEqL97MDRaOd46wN44g

_! : 1235/40 TFrooim":lsU0SS1a1r2a3r8-8A-L-LMI0N1L SETHRE, ARTHUR E. Date Date and ~nd time time 1~00//0055//8899 ~133::0066::0022 SETHRE, ARTHUR E. TFFoRROx~MPi:Ic:olRRooogggyeerrSeGG.r. viP PceeerrskkiinMnessdical Dept. 220-26-02 STuobxjieccotlosgyAMMSOeNrIvUicMesPEM RFeLdUiOcRaOl OCDTeApNtG. ATE22T0S-2CAE-082(e) SuPPbhhmooinnseesi77o33n33--33222222 CS C OOTnonouooxborO idjrdccedciitctintoontyab:bateetorAosrrMtr u44H,di,iOnynN11IU99ttthH88hhe99eatPOEO 33MRfDffuFfLiPirrcUeocee OneccRteeOoioivOfvheaeCdTT sdToAoxNacaxiOoiccnAccodoTEpSpuSyyucuTbtbSseoosCtdfftaAannoaaccn8eell(eesset)tthtteaaeteSt rrsuuEEbbPsPsmAjeeA.einn.scttstTTiohhbbneeyychelDlDemeuuitPtPtctooeaennlrtrt. sttooummtthahereiz88e((ees)) 3 15 summarizes a a UuiLtid o pphde exLonon innecctyiiitdffaayiiiege33dMdMsctueasasdlspsplyoonntthsahsteheodorearemm entaddoanmDnuattuw ufswPafoooacw---ncteyyttueeruraeahrerearrosr bffeoso ecefeeof rddnviidttnhenhu9edgectecisscdnthhtuueedmdmom yyianclicaetiianlhnl.er. uw ahTTtshihshuicecebhhtjeDD huaaacutPtPoddonroconteshst ceeee-ss-m didttueveuicdeppdayedyelnn. d3diise03senMntoaatrisffiino3onc0llcl0rloreoew awpaspseme oifn Lteheydis9ubjceecltl cahdeemniocmaals wienretheoibrserdvieetd. in male rats that received 30 or 300 ppm of the subject chemical in their diet. TGDD deeueupsPpPesoeonnndtdnfe'eot'nrnsstt assdtdtu5ueed0dccyyrrmeeaaaiin/ssnd ekedgiicciiaennaxttepebbsosoosddyeytthdhaaaatnngt ddro11u44ttpeesddstaattyyiihssaneewwxxeeppfiioooggrsshhuuttrrt,,eehewwttoioipttahhitthrhe--ettfeeesccsdthhtieiesmscmioicnwwcateealriilogglhhccttaauutssseseesiiddtgginnsiiaaffiiwddcecooaiassngneethtltly.y AALhlleesssroose faaworaddseeccarrnoee50aassSeemigg/niikinnf9issceeeaxrrnuputmomseaGadnindfdfSetiironnuettpneecrressttthiibattneiitaauflleoernttetehstsehtteoopss3att0ieerrrm-oognfn/eeekdglLceedovvoneestllerssolwwaaanssitmeansnlotosttieesdda,jwnedibbguuthtthte. pPptarahiiiemrrrea_-rffiweeladdysccoondonnutterrsooitllognliaaafnnciiikmcmaaallnosstf.. ndTToihhuferefiesrddheeemnccecrrneeetaa.ssbeeetTwhiieennenssseeerrrtuuuhmmme e5tt0seetssrmttagood/ssiktto9eelrroodwnnoaeesselleasevvnieegillnmiawfwlaiascssaanntdlythe pTtitIhrhennaaisccttmtrraoeersassaitsuusleeppeyrdppdooonrrdiiettnnusse alalletttllovhheeelleesahxhxcypypkwpoophossoiteetocdhfdhheesmmsniaiaoislszun ereitttsuhrhrharaaamtntttessn..rtttehh.AAseeulTccssthhheeeeeeccdmmooiinnsccddeiaanrlluppmhhhacacussapaeeeueussrsterseooadfefddcirddttoeeehhlcceecirroewessnaaattsssuueddeoyydfdsigsphspnereorirrorofuumvvimmoiicnddaeeensddtlddtyaahtattaa eteasdtostotertohneechlaenvgeelss wihnicthhe intesttuirsn orbesseurlvteedd iinn ht~hepeTtsweoc-ryeetarionStuodfy.hormones that Lead to the changes in the testis observed in the two-year study. TTfhheeeediDDnuugPPoonnstttudffyiinnddriienngggassrdissnuugppppooarrttpotttehhneeticcaoolnnccllhuuossrmiiooonnnassl ssttcaaattueesdde oiifnn ttthhheee Lrreeeyppdooirrstteeddcel3SlHM ltteiwsooi--oyyneesaa.rr feedin9 study regardin9 a potential hormonal cause of the Leydi9 cell lesions. DDtuuhPPeoonnhttormiionnnddaiilccaattaeelssterttahhtaattionttshheeisnnoo--1oombbass/eekrravv.aabblTlheeeyeeffffseetccattte lleetvvheealtl,, tNNhOOiEEsLL,,NOEiiLnn ittshhiissequssittvuuaddlyyenfftoorr to an airborne level of 7-0 the hoTmonai alterations is to an airborne level of 7.0 mand in I mg/kg. mg/m3 in the rat. They state the rat. that this NOEL is equiualen~ TTahheesaAAfCeCtGGyIIHHfattchhtrroeersshhoooflldd70lLiimmbiiattsedvvaallouunee tfhfooerrDut~Phhoeentcchheeimmniifccoaarllmatiiisson00...)1I mg/m3 mg/m3 TWA. TNA. (This (This sives 9ives a safety factor of 70 based on the DuPont information.) If there are questions about this information, please contact Frank Griffith If there are questions about this information, please contact Frank Griffith or me. [euie: 1225-40 cre-1a3) ccFccI::LE:UUUSSSOOU19923727655511229-9974---0--UAASLL(SLLFPIICONN-LI1143) JSSOOORIREENNNMSSOONNW,,ATESSRTTSAANNLLEEYY UUUSSSOO099S333994889771------AAULLSLLSIIPNNOII UUUUUUSSSSSSO22OI1B553O0D08655188199166999211766------------AAAUUULLLSSSLLLSSSIIIPPPNNN00OIII111L LBJJJLooIEOInnTNHNTDNDSNANA,HMHLLCC,,WDhhAUaaTAsSsSEmNmTTaERaEEnnSPPHHD.EENNMADA UUUUUUSSSSSSO22OO0S665I1&S53O07S546641i2~27554I4-------------AAAAUALLLLSLLLLLSLIIIIPINNNN0NIIII1I USUUU0SSS61OO046O94O757I656I7772--------UUU~SsSLSSSLPkPIOO0NLL1I BE-TTS, DUANE D. HD UUUUSSSS222O57758004844733347557--------AAAALLLLLLLLIIIINNNNYY1I UUUUSSSSIO22OT669099950539797575------UA-UHMMSOO0S111P01 MBMCAONKNAEAMRM,AARRAAK,,ATMHMILICECHHEAANEELLA UUUU$SSSO2OO85B1181678744348~796--------UAMMML0O0L111INI USUUU0SSS1OO2I15750979016177277-1------U-UUSMSHS0SOP1PIO0L1 BAKER, KATHLEEN A BUHR, DANIEL J UUUUSSSSOOO02BI27B~7~046O810I60---1----UVUMMHS000S111POL USUUU2sSS6z229e?657?9665a226s12-s-------UUU--sHSmSOSoP1P1O0L1 BUHR, DANIEL J bams, JK UUUUSSSS22O296861383360664I475O5--------UUUUsSSSSSSSPPPPO0O0L111 8UUS023~27830353----UUHsOSP1OL DANMS, d K US2913~7--USSPOI emma SUO32805--USSPO1 em Ae Tea ana Regards, EENNDD OOFF NOTE NOTE RRoeg9earrds8,. Perkins Roger G. Perkins DSSoUUnOGGG,,RicJJkAAeMHrEESS K. K. ZZRDRSOOOoOEBBnAATEECCHLLHHRR,,,,Ei,ckLLDDAeOAAORrNRRNTARRAHLYYLUDDRRR..EE... IM SETHRE, ARTHUR E. EFFBIIBTTEZZNGGSII,BBBBOKONNE,,NNMEMAATRRHYYLLLOO HEIBLBLEANRSD,, KEPhAIU~LETWH WILLARD, PAUL on rte--n13--6.0 5--. u_mnczsz31s2 3M MN02323182 11336600..00000011