Document o921QBp5Xaxn1RbgmRJLoQjqD

studied by highly quaVriied investigators whose reports were published in 1955,t`> 1965,<') 1968,w and 1977.o*i These workers represent the only cohort of asbestos work ers in the world in which health effects have been corre lated with definitive exposure data defined as fibers per cc. It would be premature and ill advised to change the pres ent OSHA standard of 2 fibers longer than S pm/cc for chrysotile without indications from this study population of the advisability for such change. The same TIV is as signed to other forms of asbestos not specifically named herein. The exposure level of crocidolite and amosile. particu larly of the former, must be sharply lower than that of chrysotile because of their greater potential for disease produc tion. In view of the lack of accurate information of the dose-effect relationship pertaining to these two types of asbestos, the arbitrary assignment of 0.5 fiber/cc longer than 5 pm appears reasonable and prudent for amosite. Since crocidolite may be more pathogenic than amosite, a TIV of 0.2 fiber/cc longer than 5 pm is recommended, as well as the Ala, proven carcinogen, designation (or all types of asbestos. Tabulation of Significant Findings in Two Epidemiologic Investigations of Workers in the Same Hard Rock Cold Mine Size of Cohort Number of Deaths Respiratory Cancer McDonald el alIMl 1321 Observed Expected T7 16.5 Gillam el al,," 440 Observed Expected 10 2.74 Nonmalignanr Respiratory Pneumoconiosis Respiratory TBC Silico-TBC Other Nonmalignant Respiratory Disease *37 of the 39 deaths were ascribed to silicosis. 39* 0 39 3.6 f? 5 1.85 References. 1. Campbell, W.|, Slake R.L, Brown L.L, Calher E.E., Sjoberg Selected Minerals and their Asbestilorm Varieties: Mineralogical Definitions and Identification-Characterization. Bureau of Mines Information Circular 8751, p. 14 (1977). 2. Murray, M4 Report, Department, Commission on Compensa tion of Industrial Disease. Cd. 3496, pp. 127-126, London, H. M.S.D. O90>7). 3. Merrwether, E.R.A, Price, C.W.: Report on lfleas of Asbestos on the lungs and lust Suppression in the Asbestos Industry. London, H.M.S.O. (1930). 4. Wood, W.B, Gloyne, Mj lancet *1383-1385 (1934). 5. lynch, ICM, Smith, WAj Am. J. Center 24;S6-64 (1935). 6. Doll, RSj Bril. /. Ind. Med. 7*81-86 (1955). 7. Selikoff, I.J, Churg, J, Hammond, f.C: J.A.M.A. 188:22-26 0964). 8. Wagner, |.C, Sleggs, CA, Marchand, P-- Brit. /. Ind. Med. 17: 260-271 (1960). 9. Hammond, t.C, Selikoff, l.|J Relation ( Cigarette Smoking to Risk of Death of Asbestos-Associated Disease Among Insu lation Workers in the United States, M.R.C. 5c/'. Pub. No. 8, pp. 312-317 (1973). 10. Wagnet, J.C, Gilson, J.C, Berry, C,, Timbrell, V.: Bril. Med. Bull. 27.71-96 (1971). 11. Enteriine, P.t, Henderson, V.: Arch. Ivn. Health 2*312-317 (1973). 12. McDonald, J.C, McDonald, A.Dj Preventive Med. 6:426-446 (1977). 30 13. Meurman, L.D., Kivilioto. R,, Hakama, M.: Bril. I. Ind. Med. 31:105-112 (1974). 14. Baris, VJ. el a/: Kenser 5:1-14, Finland (1975). 15. McDonald, |.C el al: Arch. [nv. Hetlth 22:677-686 (1971). 16. Knox, |.F, Doll, R5,, Hill, I.D.: Ann. N.Y. Acad. Sci. 71*526- S35 (1965). 17. Newhouse, M.U Brit. /. Ind. Med. 26:294-301 (1969). 18. Newhouse, M.L, Berry, G., Wagner, J.C, Turock, M.E.: Brit. J. Ind. Med. 29.134-141 (1972). 19. Peto, I, Doll, R., Howard, S.V, Kinlen, L.|., lewlnsohn. H.C.: Brit. I. Ind. Med. 34:169-173 (1977). 20. McDonald, |.C_- Exposure Relationships and Maglignant Me sothelioma, Opening paper (or Session V., Asbestos Symposi um, Johannesburg, So. Africa (October 3-7, 1977). 21. Newhouse, M.L, Berry, G.: Brit. /. Ind. Med. 33:147-151 (1976). 22. British Occupational Hygiene Society: Ann. Occup. Hyg. 11:47-69 (1968). 23. Gross, Pj Arch. Inv. Health 29.115-118 (1974). 24. Gillam, |.D, Dement, |.D, lemen, R.A. el ah Ann. N.Y. Acad. Sci. 277:336-344 (1976). 25. McDonald, J.C, Gibbs, G.W, lldell, F.D.K, McDonald, A.D.: Mortality after long Exposure to Cummingtonitc-Cruneri/e. To be published. Abstracted in Am. Red. Resp. D/s. 26. Knox, |3, Holmes, S, Doll, R, Hill, I.D_- Bril. /. Ind. Med. 25:293-303 (1966). 8D02 845* HFM -009716 pponr'rcn nv p/idti