Document o6jneKEZvGjVj7EaDQ56dKZw

April y, 1968 .ir. James Armstrong Reiser Alurainura & Choralcal Oompany 'frentvjood Korks ...pokane, Washington 99210 hear Hr. Arnotrong i Mr. Pogue of our Seattle office has aoked me to forward toxicity and safe handling information relative to our flrereoiotant hydraulic fluids, pydraul 312 and Pydraul A-200. The oral toxicity of Pydraul 312 shows an LD^a to rate of 6900 rag/kg and it is clasolflod as 'practically non-toxic" from the acute oral point of view. When applied to the akin undiluted and allowed to remain overnight, a barely perceptible redness occurred, giving 0 maximum ecore of 1.3/8.0, which was classed as a slight Irritant. The material proved capable of being absorbed through the skin In high doses when allowed to remain on the rabbit under a cuff. The minimum lethal dose waa somewhere over 2000 and under 3>00 mg/kg. This would fall Into the slightly toxic ' range. The material is a slight eye irritant when applied undiluted to the rabbits' eyes and there was mild discomfort and slight redness. The maximum score was 13/110 and the eye had returned to normal within three days. data curvlvod six-hour Inhalation exposure to the vapors evolved at ambient to.iperaturos following the passage of air through the material. Mo systemic effects were noted. Animal toxicity studies with Pydraul A-COO have indicated that the oral lethal done (ID50) to rats is 10,500 milligrams per kilogram. The lethal dose when the materiel was applied undiluted to the unbroken skin of rabbits Is approximately 1250 milligrams per kilogram. The skin and eye irritation end vapor inhalation tecta results were comparable to the data for Pydroul 312. > 0621322 WATER PCB-SP000000404 Mi'. Jar.iaa Armstrong -2- Aprll 9, 1963 '.,'e conclude from the above that accidental Ingestion on the part of humans la not a particular hazard in view of the high oral lethal dose In rats. Similarly, single massive skin exposures should not be Immediately harardoua. The lethal dose obtained In skin penetration studies Is such, however, that prolonged and repeated skin contact should be avoided because of possible systemic effects. In addition, prolonged and repeated skin contact may lead to skin irritation. Uo also feel that vapor Inhalation should be avoided when the fluid Is heated to eloveted temperatures. Such exposure again relates to prolonged or repeated exposures rather than short-term massive or acute exposures. In the case of the latter, workmen would not voluntarily expose themselves to concentrations that are hazardous because of irritation of the respiratory tract. I have enclosed a copy of a cur.unary of our interpretation of the data for Pydraul 312. The information applies similarly to Pydraul A-200. If I con be of any further help, please let me know. Sincerely. ItKKlcJS CCi D. ft. Pogue - Seattle BCC: N. T. Johnson Knclooure H. Aminet Kelly, M.D. Medical Director 0621323 WATER PCB-SP000000405