Document o65rO8J6xo81mJMvbjrGDL0o

DOW CONFIDENTIAL INFORMATION R & D REPORT FILE NUMBER CRINUMBER HEALTH & ENVIRONMENTAL SCIENCES THE DOW CHEMICAL COMPANY DEPARTMENT Health & Environmental Sciences-Texas LABORATORY REPORT CODE TXT:DR-0296-5288-001 DATE ISSUED March 1. 1988 LAB. NO. PROBLEM NO. 485 0000136 title D-245 CONDENSED VENT GASES FROM UNIT I, OYSTER CREEK DIVISION 1/5/88: ACUTE TOXICOLOGICAL PROPERTIES 2 PAGES IN FULL REPORT AUTHOR(5)/MASTER NUMBERS) D. D. Lockwood (052620) AUTHOR(S) SIGNATURES) __ `(L/oL'/gg EO-fl .S1ANAT/JRF f .9 i/uw S'/"Pf . Youn^ (077384) DESCRIPTIVE SUMMARY WITH CONCLUSIONS Thi* report is: INTERIM ED FINAL and mainly: IS] NEW REVIEW A sample of D-245 condensed vent gases from Unit I, Oyster Creek Division 1/5/88 was submitted to the Acute Toxicology Laboratory of Health & Environ mental Sciences-Texas for acute toxicological evaluation. The test material, a gray liquid, was submitted by Vinyl Chloride-Unit I/EDC plant, Freeport, Texas. The DOT (Department of Transportation) test for corrosiveness to skin and the repeated skin irritation test were conducted using New Zealand White rabbits (Ray Nichols Rabbitry, Lumberton, Texas). Acute oral studies were conducted using male Sprague-Dawley rats (Charles River Breeding Laboratories, Inc.,Wilmington, MA). A Department of Transportation (DOT) test for corrosiveness to the skin was conducted. A corrosive material is one that causes irreversible change or destruction to the intact skin of an albino rabbit after an exposure period of 4 hours or less. The test procedure used is described in the Code of Federal Regulations. Title 49, Section 173,240, Appendix A. A 1-hour and 4-hour exposure of the test material to the clipped backs of 6 rabbits resulted in slight erythema, moderate edema, but no necrosis. The test material, there fore, is considered not corrosive by the DOT test after an exposure of either 1 or 4 hours. ARE MATERIALS DESCRIBED IN THIS REPORT ON TSCA INVENTORY? IF NO. LIST MATERIALS ON REVERSE SIDE OF THIS PAGE THAT WE WILL USE OR PRODUCE COMMERCIALLY THAT WILL REQUIRE A PMN DISTRIBUTION: DEPARTMENT FILES RAD ADMINISTRATION CENTRAL REPORT INDEX (566 Bldg. Midland) SEE ATTACHED LIST FORM 04303 Printed R-6-86 YES B NO DO 078471 rONFTDFNTTAl The Dow Chemical Company Study ID TXT:DR-0296-5288-001 Page 2 of 2 Because the test material was not corrosive to the skin by the DOT test, a repeated skin irritation test was conducted. In the skin irritation test, the test material was topically applied to intact and abraded skin of a New Zealand White rabbit at 3 sites. The confined sites on the abdomen, received 3 (abraded skin) or 5 (intact skin) 0.5 ml applications. The unconfined site located on the right ear pinna received five 0.1 ml applications. Prolonged (24 hrs) and repeated exposures resulted in slight to moderate erythema to both the intact and abraded skin. Superficial necrosis was observed on the intact skin. No erythema was observed on the ear after prolonged contact; however, slight erythema was observed after repeated applications. The acute oral toxicity is low; range-finding tests indicate the oral LD50 for male rats is >1000 mg/kg when fed as a 10% solution in corn oil. Three rats/dose level were administered 1000, 500, or 250 mg/kg of the test material by single-dose gavage. All rats appeared healthy and gained weight during the 2-week observation period. No lesions were observed upon gross pathological examination of all rats at the 2000 mg/kg level 2 weeks after treatment. Because superficial necrosis was observed on the intact skin after 24-hours contact, the eye irritation and acute percutaneous absorption tests were not conducted. The test material is presumed to be corrosive to the eye. \ DOW CONFIDENTIAL DO 07847? C:ONF TDFNT J A1,