Document o2rjy5aEOVyJy1Jm293Yp75o

M*. f /! SPONTANEOUS ANGIOSARCOMAS OF TITS LIVER IN ANIMALS ri r~i. ..Tn '"'f <? % c n^ a*tx t Vt-n Th* t K .C * v: animals has never seen this lesion. I have in my files rnccrr!:; of over 11,000 rats '.-.'ill different strains and have never seen this lesion. lUCS-----In mice Angiosarcoma does spontmocisly occur. This is zxxJtks in the Haired and Hairless strain H.2. mouse. Hemangio endotheliomas (Angiosarcomas) were observed in 45 out of 251 jrl the control groups. v~ / f cpo Deringer, M. K., J. of the National Cmcer Institute. Vol: 12: 437-445, Oct. 1951. As would ibis be expected when (C-amiroazotoluene) was subcutaneously inoculated the ircideme of angiosarcomas increased. ----Ibid; 1?: 533-53H3-956 Swiss Albino mice have a spontaneous 3 % occurrence of angiosarcoma of the liver. r\. * j iT jt 4 X !> EXPERIMENTAL ANGIOSARCOMAS IN ANIMALS DIE TO HTCROTRAST c 1936-------Cappllary angiosarcomas were produced in mice by IDOS Selbie, F.t Experimental Production al Sarcoma with x Thorotrast. lancet 2: 847. 1938-.---Reticulosarocmas(angiosarcomas) of the Liver was produced by intraveous injections. Onufrio, C., Su di un caso di Reticulosarcoma sperimentale do Thoroirast. Folia med. 24: 12^5- (probably used different spcies) ARSENIC EXPERIMENTAL IN ANIMALS A?H ITS EFFECT ON MAN An excellent monograph on Arsenicals, has been written by A. Furst and will be published in the future by the World Health Organisation working group on Evaluation of Carcinogenic Risks of Chemicals to Kan. I 1 DTH 0000lr7795 \ r *' * -t~~- ~ n*~* --.-r tt*"?') --* , *.T-*rr: Ifi ti'Oi^ocLurui t F. a* 9 | JISriti^n /* *.. .* . nh i -- - -- - - -- --* Ure thane - Kerrold, K. M., Journal of the NationAL Cancer "r.r-tituto. J?: 1C?-?, 1?>7. Sibcut. administration to Syrian Hamsters. Otsuka, H. and Kuwahara, A., Gann 62:147-156,1971. By oral administration and subcutaneous injection to DDD & BAL b/c strain mice. Journal of the National Cancer Institute 34: 341-847, 1965 Gave intraperitoneal injections to D3A/2e3De strains or nice. 1,2-DimethyIhydrazine Dihc/drochloride------ Syrian Golden Hamsters were given in water daily 0.156 mg. to the female and 0.161 mg. to the male. Angiosarcomas occurred in 89 $ of the females and 82 $ in the males.' The tumors were in the livers, lings, muscle, heart, and pancreas No such .tumor is seen in the control. Toth, B,, Cancer Research, 32 : 2818-2827, 1972 Ethylhydrazine hydrochloride----o.ol25 % was given in arinkihg water and 38 % vascular tumors were produced in Swiss Albino strain mice. Toth, B.,Scientific Proceedings, AJl.P.B. San Fran 1974 n,Butyl-hydrazine KCL--only lung cance.r. . l-carbamyl-2-phenylhydrazine--only lung cancer CONTROL INCIDENCE OF ANGIOSARCOMA IN THE SWISS ALBINO MOUSE 15 5%. Methylhydrazine--(A rocket fuel componentJ^Syrian Golden Hamsters received 0.01 $ in drinking water. AngioSarccxa of the liver (Lalignant Histiocytoma) (Kupffer Cell Sarcoma)-was produced in 32 % of the females and 54 of the males. . Latency period 70 and 73 weeks,. Ho such tumor was seen in the controls, PTH 000017796 ' \ /> / Toth. B., and Shi^'*>7, F. Center- Research 33: 2744--2753, 19?5* 1 - rn^u,,---1- - % 1-----w- IT--y- - -- - 4* w t* ^WlUbAI. A -- -* ' LU.A.01I Xli UXJLiiAJUlg ,A>r / > '^ r` / . /* - Swiss rice. Angies-Tcrmas of the liver cscv.rrui i:: 3 cut cT ar.i in the controls 4 out of 44-. Toth, B. 2nd Bkimixax Shimizu. H. Journal of the national Cancer Institute. 52: 2.41-251, 1974. ARE EMVEC-lSNm HAZARDS I" TIPS GROUP? Hydrazines are used in industry as a rocket propellent. Honomethyliiydrazines are used as corrosive agents. 4 fr'V / Maleic hydrazide used as a herbicideThydrolyned to hydrazines. 2- Hydroxyethylhydrazine is used to ripen pineapples and is sprayed. Phenylhydraz ine is used in medicine for polycythemia vera. NEPHROBLASTOMA Since Professor C. Maltoni mentioned the high incidence of nephroblastoma in rats treated with Vinyl Chltride, a biief statement i included for the Interagency groip and the Environmental Protection Agency Task Force. Renal Adenocarcinoma in our population ias shown a rapidlyincreasing incidence with age in both sexes. This is well documented by the State of California, Alameda County, Department of Public Health, California Tumor Registry (15SO--1969) A review on Cancer of the Kidney-Etiology, Epiieniology, and Pathology is recently published by J.L. Benninfton in Cancer Vol 32: 1017--1029, Nov. 1973. In view of Dr,, Kkltoni's experiments should not the Vinyl Chloride workers and families be studied with this lesion in mindj 45" torn. 4> 7~M . % ..O . DTH OOOO1779