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OCCUPATIONAL HEALTH BULLETIN NORTH CAROLINA STATE BOARD OF HEALTH* J. W. R. Norton, M. 0., State Health Director Raleigh THRESHOLD LIMIT VALUES FOR 1962 CONSULT LOCAL HEALTH DEPARTMENTS AND PHYSICIANS CONTROL HEALTH HAZARDS TO EMPLOYEES AT WORK PREVENT INDUSTRIAL DISEASES *Made Avai1able by The Occupational Health Section (SEE INSIDE COVER) ADVISORY GUIDE SERIES - I - |g 6 2 Revision (Replaces issue of November 1961) SEPTEMBER 1962 OLI 3787 PUBLISHED IN CONFORMITY WITH / GENERAL STATUTES OF NORTH CAROLINA <i30-|i) REPRINTED WITH PERMISSION FROM THE AMERICAN CONFERENCE OF GOVERNMENTAL INDUSTRIAL HYGIENISTS PERMISSION GIVEN TO REPRODUCE THIS MATERIAL, COPYRIGHT 1962, BY LETTER DATED AUGUST 16, 1962 OLI 3788 THRESHOLD LIMIT VALDES FOR 1962 Adopted at the 24i!> Annual Meeting of the American Conference of Governmental Industrial Hygienists Washington, D. C., May 13-15, 1962 Threshold limits should be used as guides in the control of health hazards and should not be regarded as fine lines between safe and dangerous concentrations. They represent conditions under which it is believed that nearly all workers may Lj repeatedly exposed, day after day, without adverse effect. The values listed refer to time-weighted average concentrations for a normal workday. The amount by which these figures may be exceeded for short periods without injury to health depends upon a number of factors such as the nature of the contaminant, whether very high concentrations even for short periods produce acute poisoning, whether the effects are cumulative, the frequency with which high concentrations occur, and the duration of such periods. All must be taken into consideration in arriving at a decision as to whether a hazardous situation exists. Special consideration should be given to the application of these values in assessing the health hazards which may be associ ated with exposure to combinations of two or more substances. Threshold limits are based on the best available information from industrial experience, from experimental studies, and, when possible, from a combination of the two.* These values are based on various criteria of toxic effects or on marked dis comfort; thus, they should not be used as a common denominator of toxicity, nor should they be considered as the sole criterion in proving or disproving diagnosis of suspected occupational disease. These limits are intended for use in the field of industrial hygiene and should be employed by persons trained in this field. They are not intended for use, or for modification for use, (1) as a relative index of toxicity, by making a ratio of two limits, or (2) in the evaluation or control of community air pollution or air pollution nuisances. These values are reviewed annually by the Committee on Threshold Limits for changes, revisions, or additions as further information becomes available. The Committee welcomes the suggestion of substances to be added to the list and also comments, references, or reports of experience with these materials. "Documentation of Threshold Limit Values" is a compilation by the Committee on Threshold Limit Values of the best available technical evidence substantiating these VALDES. It can be purchased from the Secretary-Treasurer, American Conference of Governmental Industrial Hygienists, 10l4 Broadway, Cincinnati 2, Ohio, price $4,,00. -1- OLI 3789 RECOMMENDED VALUES (In Alphabetical Order) ce Acetaldehyde--------------------- ------------------------------------------- Acetic acid------------------------------------------------------------------ Acetic anhydride---------------------------------------------------------- Acetone-------------- ---------------------------------------------------------- Acetonitrile------------------------------------------------------------------ Acetylene tetrabromide------------------------------------------------ Acrolein---------- ;-------------------------------------------------------------- Acrylonitrile - Skin--------------------------------------------------- Aldriri (l,2,3i*;,10,10-hexachloro-lI4,1fa,5j8l8a- hexahydro-1,4,5,8-dimethano-napthalene) - Skin- Allyl alcohol - Skin---------------------------------------------------- Aliyi chloride;--------------------------- ---------------------------- Allyl' glycidyi ether (AGE)---------------------------------------- Ally! propyl disulfide-------------------------------------------------------- Ammonia----------------------------------------------------------------------------------Ammonium sulfamate (Ammate)---------------------------------- --------- - Amyl acetate-------------- ----------- --------------------------------------------- Amyl alcohol (isoamyl alcohol)------------ ----------------------------- Aniline - Skin-------- -------- ----- ----------------- ---------------------------- Antimony--------------------------------- ----------------------------------------------ANTU (alpha-naphthyl-thiourea)--------------------------- ------- ----- Arsenic----------------------- -- -------------- ----------------- ------ Arsine----------- -------------------------------------------------------------------- Barium (soluble compounds)-------------- ------------------- ------------ Benzene (benzol)---------------------- ---------------------------------- -------- Benzyl chloride-------------------------------------------------------------- ---- Beryllium---------------------------------------------------------------------- -------- Boron oxide------------------- -- Boron trifluoride----------------------------------------- ------------ ---------- Bromine-----------------------------------------------------------------------------------Butadiene (1, J-butadiene)------------------------- ----- ----- ------ - 2-Butanone (methyl ethylketone)-------------------------------------- 2-Butoxy ethanol (Butyl Cellosolve)--------------------------------- Butyl acetate (n-butyl acetate)-------------------------------------- tert. Butyl alcohol------------------------- -- ------------------ ---- Butylamine------------ --------------------------------------------------------- ------- n-Butyl glycidyi ether (BGE)-------------------- -- Butyl mercaptan------------------------- ------------------------------------------- p-tert, Butyltoluene-------------------------------------------------------- -- Cadmium oxide fume----------------------------------------- ------------------- Calcium arsenate------------------- :---------------------------- --------- -*-- ppm+ 200 10 5 1,000 40 1 0.5 20 --- 2 5 10 2 100 -- 200 100 5 -- -- 0.05 -- 25 1 -- --- 1 0.1 1,000 200 50 200 100 100 5 50 10 10 Ms/M3+ 360 25 20 2,400 70 14 , 1.2 ' ^5- 0.25 5 .. 15 45 12 70 15 1,050 360 19 0.5 0.3 0.5 0.2 0.5 80 5 0.002 15 3 0.7 2,200 590 240 950 300 300 15 270 35 60 0.1 1 -----------------1962 Revision OLI 3790 Note: The word "Skin" following a substance indicates that the liquid can penetrate the skin to contribute to the exposure. - 2- Substance Carbon dioxide------ ------------------- ------- ----- ------- ----- ----- ------- Carbon disulfide - Skin------------------------------------------------------- Carbon monoxide---------------------------------------------------------------------- ^Carbon tetrachloride - Skin----------------------------------------------- Chlordane (1,2,4,5,6,7,8,8-octachloro-3a,4,7,7a-tetra- hydro-4,7-methanoindene)------------------------------------------------- Chlorinated camphene, 60%--------------------------------------------------- Chlorinated diphenyl oxide------------------------------------------------- Chlorine---------------------------------------------------------------------------------- Chlorine dioxide-------------------------------------------------------------------- Chlorine trifluoride------------------------------------------------------------ Chloroacetaldehyde---------------------------------------------------------------- Chlorobenzene (monochlorobenzene)------------------------------------ Chlorodiphenyl (k2% Chlorin^l - Skin-------------------------------- Chlorodiphenyl (54# Chlorine) - Skin-------- --------------------- Chloroform (trichloromethane)----- --------------------------------------- 1-Chloro-l-nitropropane------------------------------------------------------- Chloropicrin--------------------------------------------------------------------- - Chloroprene (2-chloro-l,3-butadiene)------------- ----- ---------- Chromic acid and chromates (as CrO_)------------------------------ Crag herbicide (sodium 2-/2,4-dichlorophenoxy7 ethanol hydrogen sulfate)--------------------------------------------- Cresol (all isomers) - Skin------------------ ---------------------- Cyanide (as CN) - Skin------------------------------------------------------- - Cyclohexane------------------ ----------------------------- -------- --------- -- Cyclohexanol---------------------------------------- ---- ------------------- -- Cyclohexanone--------------------------------------------------------------------- -- Cyclohexene----------------------------------------------------------------------------- 2, 4-D (2, 4-dichlorophenoxy-acetic acid)--------------------- DDT (2, 2-bis /p-chlorophenyl/- It 1,1-trichloroethane) Skin- Decaborane - Skin------------------------------------------------------------------ Diacetone alcohol (4-hydroxy-4-methyl-2-pentanone)----- Diborane-------------- ---------------------------------------------------------------- *1,2-Dibromoethsne (Ethylene dibromide)------------ ----- ----- o-Dichlorobenzene---------------------- ------- ------------------------------- p-Di chlorobenzene--------------------------------------------------------------- - Dichlorodifluoromethane----------------------------- ------ --------------- - 1, 1-Dichloroethane------------------------------------------------------------- 1, 2-Dichloroethane (ethylene dichloride)--------------------- 1, 2-Dtfcloroethylene-------------- --------------------------------------------- Dichloroethyl ether--------TM--------------- Dichloromonofluoromethane----- -------------------------------------------- 1, 1-Dichloro-l-nitroethane-------------------- ----------------- ---- Dichlorotetrafluoroethane------------------------------------------------ Dieldrin (l,2,3,4,10,10-hexachloro-6, 7-epoxy-l,4, 4a, 5,6,7,8,8a-octahydro-l,4,5,8-dimethanonaphthalene) - Skin---------------------------------- -- Diethylamine---------------------------------------------------------------------------- Difluorodibromomethane---------------------- --------------------------------- ppra+ 5,000 20 100 10 1 0.1 0,1 1 75 50 20 0.1 25 400 50 50 400 0.05 50 0.1 25 50 75 1,000 100 50 200 15 1,000 10 1,000 25 100 Mg/M5+ 9,000 6o 110 65 0.5 o.5 o.5 5 0.5 0.4 5 350 1 0.5 240 100 0.7 90 0.1 15 22 5 1,400 200 2Q0 1,350 10 1 0.3 240 0.1 190 300 450 4,950 400 200 790 90 4,200 60 7,000 0.25 75 860 *1962 Revision - 3- OLI 3791 Substance Diglycidyl ether (DGE)------------------------ -------------------------------- Diisobutyl ketone----------------------------------------- ,------------ ------- -- Dimethylaniline (N-dimethylaniline) - Skin--------------- Dimethylfonnamide-------------------------- -- 1, 1-Dimethylhydrazine - Skin------------------------------------------- . Dimethylsulfate - Skin----------------- ---------------------- .-------------- Dinitrobenzene - Skin------------------------------- ,---------------------------; Dinitrotoluene - Skin----------------------------------------------- -- Dinitro-o-cresol - Skin---------------------------------- ------------- ,-- Dioxane (diethylene dioxide)------------------- ------------------------- Dipropylene glycol methyl ether-------------------------------------- - EPN (O-ethyl O-p-nitrophenyl thionobenzenephosphonate) - Skin------------------------------------------------------------------------------- Ethyl acetate---------------------------------- ---------------- Ethyl acrylate - Skin------------------------------------ Ethyl alcohol (ethanol)--------------------------------- Ethylamine---------------------------------------- --" Ethylbenzene--------------------------------------------- Ethyl bromide----------- --------------------------- ---------- Ethyl chloride---- ------------------------- --- ------- Ethyl ether------------------------------------------------- Ethyl formate--- ----------- --------------- ------ ---- Ethyl mercaptan----------------------- ---------------------- -- Ethyl silicate----- ---------------------------------------- -- Ethylene chlorohydrin - Skin------------ ----------- Ethylenedi amine----------------------------------------------- Ethylene glycol dinitrate - Skin--------------- Ethylene imine - Skin------------------------------------- Ethylene oxide------------------------------------------------- 2-Ethoxyethanol (Cellosolve)------------------------ 2-Ethoxyethylacetate (Cellosolve Acetate) Ferbam (ferric dimethyl dithiocarbamate)- Ferrovanadium dust------------------------------------------ Fluoride-- ------------------------------------- ------- ------- . Fluorine------------------------------------- --------------------- Fluorotrichloromethane--------------------------------- Formaldehyde-------:--------------------------- ----- ----- Furfuryl alcohol-------------------------------- --------------- Gasoline-----------TM-------------- Glycidol (2,3-epoxy-1-Propanol)-----------------------Heptane (n-heptane)-------------------------------------------Hexane (n-hexane)-------------------- ----- ------ -- Hexanone (methyl butyl ketone)------------------------sec-Hexyl acetate------------------------ --------------------- -- Hexone (methyl isobutyl ketone)-------------------Hydrazine - Skin-----------------------------------------------Hydrogen bromide---------------------------------------------------Hydrogen chloride-------------------------------------- ------ Hydrogen cyanide - Skin---------------------------------------* *J9&2 Revision -4- ppm+ 10 50 5 20 0.5 1 -- -- -- 100 100 ___ 400 25 1,000 25 200 200 1,000 400 100 250 100 5 10 0.2 5 50 200 100 -- -- -- 0.1 1,000. 5 5 50 500 50 500 500 100 100 100 1 3 5 10 Mg/M?+ 55 290 25 60 1 5 1 1.5 0.2 360 600 0.5 1,400 100 1,900 45 870 890 2,600 1,200 300 640 850 16 30 1.2 9 90 740 540 15 1. 2.5 0.2 5,600 6. 20 200 2,000 150 2,000 1,800 410 590 410 1.3 10 . 7 11 OLI 3792 Hydrogen fluoride-- Hydrogen peroxide, 9056-- Hydrogen selenide------------------------ Hydrogen sulfide------------------------- Hydroquinone--------------------------------- Iodine-------------------------------------------- Iron oxide fume---------------------------- Isophorone------------------------------------- Isopropylaraine--------------------------- -- Isopropyl glycidyl ether (IGE)- Lead------------------------------------------------ Lead arsenate------------------------ Lindane (hexachlorocyclohexane, gamma isomer)-------------- Lithium hydride------------------------------------------ .------------------------- - Magnesium oxidefume------------------------------------------------------------- Malathion (0,0-dimethyl dithiophosphate of diethyl. mercaptosuccinate) - Skin------------------------------- .------------- Manganese------- -------------- ------ ---------------------------------------------------- Mercury------------------------ -- Mercury (organiccompounds) - Skin--------------------------------- -- Mesityl oxide-------------------------------------------------------------------- -- Methoxychlor (2,2-di-p-methoxyphenyl-l,l, 1-trichloroethane)----------------------- --------------- .--:--------------. Methyl acetate-----------------------------------------------------.---------------- - Methyl acetylene------------------------ ----------------- --------------- --------- Methyl acrylate - Skin------------------------------------------------------- Methylal (dimethoxymethane)--------------------------------------------- Methyl alcohol (methanol)-------------------------------------------------- Methyl bromide - Skin---------------------------------------------------------- Methyl cellosolve (2-methoxyethanol)------------------------------- Methyl cellosolve acetate (ethylene glycol monomethyl ether acetate)-------------------------------------------------------------------- Methyl chloride---------------------------------------------------------------------- Methyl chloroform (1,1,1-trichloroethane)---------------------- Methylcyclohexane-------------- ------------------------------------------------- Methylcyclohexanol--------------------------- ----------------------------------- Methylcyclohexanone---------- ---------- -------- ----- ----- --------- Methyl formate------------------------------------------------------------ --------- Methyl isobutyl carbinol (methyl amyl alcohol)----------- Methyl mercaptan-------------------------- ------------------------------ -------- a-Methyl styrene---------------------- Methylene chloride (dichloromethane)------------------------------- Monomethyl aniline - Skin-------------- ----------------------------------- Molybdenum* (soluble compounds)-- (insoluble compounds) Naphtha (coal tar)--------- Naphtha (petroleum)------- Nickel carbonyl---- ----- Nicotine - Skin------------- ppm+ Mg/M3t 3. l 0.05 20 -- 0.1 -- 25 5 50 -- -- --. --. -- ___ -- 1 Pi -- 25 ___ 200 1,000 . 10 1,000 200 20 25 2 1.4 0.2 30 2 1 15 l4o 12 240 0.2 0.15 0.5 0.025 15 15 5 0.1 0.01 100 15 610 1,650 35 3,100 260 80 80 25 100 500 500 100 100 100 25 50 100 500 . 2. 120 210 2,700 2,000 470 460 250 100 100 480 1,750 9 ------* 200 500 0.001 -- 5 15 800 2,000 0.007 0.5 *1962 Revision -5- OL1 3793 Substance Nitric acid--------------------------------------------------- p-Nitroaniline - Skin--------------------------------- Nitrobenzene - Skin------------------------------------- Nitroethane---------------------------------------- ---------- Nitrogen dioxide------------------------------------------- Nitroglycerin - Skin----------------------------------- Nitromethane------------------------------------------------- 2-Nitropropane----------------------------- ---------------- Nitrotoluene - Skin------------------------------------ Octane------------ -------------------------------------- ---------- Ozone-------------------------------- ---------------------------- Parathion (0, 0,diethyl-0-p-nitrophenyl thiophosphate) - Skin------------------------------ Pentachloronaphthalene - Skin---------------- -- Pent achlorophenol - Skin-------- ---------------- Pentanone (methyl propyl ketone)------------- Pentene----------------------- ----------------------------------- Perchloroethylene (tetrachloroethylene)- Perchloromethyl mercaptan-------------- ---------- Phenol - Skin------------------------------------------------ Phenyl glycidyl ether (PGE)---------- ----- ------ Phenylhydrazine - Skin------------------------------- Phosgene (carbonyl chloride)------------------ Phosphine---------------------------- :--.------- ------------ Phosphoric acid-------------------------------------------- Phosphorus (yellow)------------------------------------- Phosphorus pentachloride------------ -------------- Phosphorus pentasulfide----------------------------- Phosphorus trichloride-------------------------------- Picric acid - Skin--------------------------------------- Propyl acetate-------------- ------------------------------- Propyl alcohol (isopropyl alcohol)---------------------------------- Propyl ether (isopropyl ether)----------- ----------- `----------- n-Propyl nitrate--------------------------------- --------- Propylene dichloride (1,2-dichloropropane)------------------- ---------- Propyleneimine - Skin------------------------------- -- Propylene oxide--------------------------------------------- Pyretbrum-------------------------------------------------------- Pyridine-------------------------------------------------------- Quinone--------------------------------------------------------- -- Rotenone (commercial)---------------------------------- Selenium compounds (as Se)---------------- -------- ^Sodium fluoroacetate (1080) - Skin--------- Sodium hydroxide------------------------------- ---------- Stibine----------------------------------------------- ------- Stoddard solvent------------ ---------- ----- --------- Strychni ne------------------------ -- 1962 Revision -6- ppm+ Mg/M5 10 1 1 100 5 0.2 100 25 5 500 0.1 25 6 5 310 9" 2 250 90 30 2,350 0.2 ---- -- -- 200 ,000 100 0.1 5 50 5 1 0.05 -- -- -- 0.5 -- 2C0 0.1 0.5 0.5 700 2,950 670 0.8 19 310 22 4 0.07 1 0.1 1 1 3 0.1 84o 400 980 500 2,100 25 110 75 25 100 -- 5 0.1 --- --- --- 0.1 500 -- 350 60 240 5 15 0.4 5 0.1 r 0.05 2 0.5 2,900 0.15 OL1 3794 i Substance Styrene monomer (phenylethylene)-------------------------------------- Sulfur dioxide-------------------------- ------------------------------------------ Sulfur hexafluoride---------------------------- -------------------------- Sulfuric acid------------------------ ----------------------------------------- Sulfur monochloride---------- ---------------- ---------------------------- --- Sulfur pentafluoride-------- -------------------------------------------------- TEDP (tetraethyl ditbionopyrophosphate) - Skin------------ TEPP (tetraethyl pyrophosphate) - Skin------------------------- - Tellurium-------------------------------------------------------------------------------- 1,1,2,2-Tetrachloroethane - Skin-------------------------------------- Tetrahydrofuran------------------------------------------------- --------------- -- Tetranitromethane------------- ------ -------------------------------------------- Tetryl (2,4,6-trinitrophenylinethylnitramine) - Skin- Thallium (soluble compounds)--------------------------- ------------- - Thiram (tetramethyl thiuram disulfide)------------- ----------- Titanium dioxide--------- -------------------------------------------------------- Toluene (toluol)------------------------------------------- ------------------ -- o-Toluidine - Skin------------------------------------ -- Tolylene-2, 4-diisocyanate--------------------------- --------------------- Trichloroethylene------------------------------------------------------------------ Trichloronaphthalene - Skin--------------------------- ------------------ 1,1,2-Trichloro 1,2, 2-trifluoroethane------------------------- Triethylamine---------- -------------- ----------------- ------------------------- Trifluoromonobromomethane--------------------------- -- Trinitrotoluene - Skin----------------------------------------- -- Triorthooresyl phosphate----------------------------------------------------- Triphenyl phosphate----------------- ------------------------------------------ Turpentine------------------------------------------------- -------- ------------------- Uranium (soluble compounds)-------- ----------------------------------------------- (insoluble compounds)------------------------------------------------------ - Vanadium (V205 dust)------------ ------------------------------------------------------------ (V205 fume)---------------------------------------------- -------------------- Vinyl chloride (chloroethylene)------------ ----------------------- Vinyl toluene----------------------------------------------------------- ------ -- Warfarin (5-/a-acetonylbenzyl7-4-hydroxycoumarin)------Yttrium--------------- --------------- --------- ------------------------------ ------ Xylene (xylol)---------------------------------------------------------------- Xylidine - Skin---------- ---------------------------------------------------Zinc oxide fume--------------------------------------------------- --------- ---- Zirconium compounds (as Zr)---------------------------------------------- * ppm+ K&/K + 100 5 1,000 1 0.025 -- -- -- 5 200 1 -- -- -- -- 200 5 0.02 100 -- 1,000 25 1,000 -- -- -- 100 ___ -- 420 13 6,000 1*1 6 0.25 0.2 0.05 0.1 35 590 8 1.5 0.1 5 15 750 22 0.14 520 5 7,600 100 6,100 1.5 0.1 3 560 0.05 0.25 --- 0.5 -- 0.1 500 1,300 100 48o 0.1 5 200 870 5 25 -- 5 -- 5 *1962 Revision OLI 3795 -7- Radioactivity: For permissible concentrations of radioisotopes in. sir, see U. S. Department of Commerce, National Bureau of Standards, Handbook 69, ''Maximum Permissible Body Burdens and Maximum Permissible Concentrations of Radionuclides in Air and ir. Water for Occupational Exposure", June 5* 1959- Also, see U. S. Depart ment of Commerce, National Bureau of Standards, Handbook 59* "Permissible Dose from External Sources of Ionizing Radiation", September 24, 1954, and addendum of April 15, 1958, *1962 Revision +Parts of vapor or gas per million parts of air by volume at 25C and 760 mm. Hg pressure. ^Approximate milligrams of particulate per cubic meter of air. MINERAL DUSTS Substance m.p.p.c.f.S SILICA Crystalline Quartz, Threshold Limit calculated from the formula---------------------------------------------- Cristobalite " " Amorphous, including natural diatomaceous earth 250 $Si0z+5 20 SILICATES (less than 1% crystalline silica) Asbestos------------------------------------------------------------------------------------- Mica--------------- '----------------------------------------------------------------------------Soapstone-----------------------------------------------------------------------------------Talc---------------------------------------------------------------------------------------------Portland Cement------------------------------------------------------------------------Miscellaneous (less than 1^ crystalline silica)-------------- 5 20 20 20 50 50 Note: The percent of crystalline silica in the above formula and tables is based on the amount found from an analysis of the air-borne dust. Conversion factors mppcf x 35-3 = million particles per cubic meter = particles per c.c. 6 Millions of particles per cubic foot of air, based on the standard procedure for sampling and counting dusts adopted by the Fifth Annual Meeting of ACGIH (1942). 1962 Revision OLI 3796 -8- TENTATIVE VALUES Substance Benzidine---- -------- ----------------------------- -------------- tert. Butyl chromate (as CrO_)------ -------------------------------- Camphor-------------- -------------------------------------------------------------Chlorobromomethane--------------------------------------- ----- -------------- '`Cobalt---------------------------------------------------------------------------------DDVP (0,0-Dimethyl-2,2-dichlorovinyl phosphate)------Dimethyl acetamide - skin------------------------------------------- -- Endrin (l,2,3,4,10,10-hexachloro-6, 7-epoxy-l,4,4a, 5,6,7*8, 8a-octa hydro l,4-endo-5, 8-dimethanonaphthalene)----------------------------------------------- Ethanolamine----------------------------------------------------------------------Eeptachloro (1,4,5,6,7*8,8-heptachloro-3a,4,7,7a- tetrahydro-4,7-methanoindene)-----------------------------------Ketene----------------------------------------------------------------------------------B-Naphthylamine------------ ---------------------------------------------------1-Nitropropane---------------------------------------------------------------- --- *N-Nitrosodimethylamine (Dimethylnitrosamine)-----------Oil (mineral)------------------------------------------------------------ --------Osmium tetroxide---------------------------------------------------------------Pentaborane------------------------------------------------------------------------Perchloryl fluoride----------------------------------------------------------Phosdrin (2-carbomethoxy-l-methyl vinyl dimethyl phosphate)-----------------------------------------------------------------------Platinum compounds (as Pt.)-------------------------------------------Sulfuryl fluoride--------------------------------------------------------------Systox---------------------------------------------------------------------------------- 2,4,5T (2,4,5-Trichlorophenoxyacetic acid)---------------Teflon (JO decomposition products-*------------ ----------------1,3,3-Trichloropropane----------------------------------------------------- ppm+ 200 10 5 0.5 0.5 0.005 3 5 50 Approx. Mg. per Cu. M.+ A 0.1 5 1,050 0.5 1 35 0.25 19 1 0.25 90 5 0.002 0.01 13.5 0.1 0.002 20 0.2 + Parts of vapor or gas per million parts of air by volume at 25C and 760 mm. Hg. pressure. + Approximate milligrams per cubic meter of air. *1962 addition. A numbers, see Appendix appendix A^" Benzidine. Because of high incidence of bladder tumors in man, any exposure, including skin, is extremely hazardous. 2 A B-Naphthylamine. Because of the extremely high incidence of bladder tumors in workers handling this compound, and the inability to control exposures, B-naphthylamine has been prohibited from manufacture, use and other activities that involve human contact by the State of Pennsylvania. OLI 3797 -9- appendix (Continued) 3 A N-Nitrosodimethylamine. Because of extremely high toxicity and presumed carcinogenic potential of this compound, contact by all routes should not be permitted. Teflon decomposition products. At least one identified component of Teflon decomposition products is extremely toxic, but, in the absence of more com plete toxicity information and suitable analytical methods, a definite threshold limit value is not recommended at this time. Harry B. Ashe E. J. Baier Allan L. Coleman Hervey B. Elkins Bernard Grabois Wayland J. Hayes Herbert E. Stoteinger, Chairman Keith Jacobson Harold N, MacFarland William F. Reindollar Russell G. Scovill Ralph G. Smith Mitchell R. Zavon - in - OL1 3798 JMJt NOTICE OF INTENDED CHANGES for 1975 REVISIONS (Excluding substances or operations with carcinogenic potential) (for which, see Appendix A) SUBSTANCE FROM 1974 TEV Cobalt, metal fume & dust 2-Hexanone (Methyl butyl ketone) Methylene chloride Nickel carbonyl Phthalic anhydride Silica, amorphous 0.1 mg/m3 100 ppm 100 ppm 0.001 ppm Ala 2 ppm (see Mineral Dusts) TO PROPOSED 1975 LIST 0,01 mg/m^ 25 ppm 200 ppm 0.1 ppm 1 ppm NEW ADDITIONS (Excluding Substances or Operations with Carcinogenic Potential) (see Appendix A) SUBSTANCE PROPOSED LIMIT Antimony trioxide, handling & use 0,5 mg/nr as Sb Arsenic trioxide, handling & use 0.25 mg/nr as As Borates-tetra, sodium salts Anhydrous 1 mg/m;? Pentahydrate 5 mg/m3 Decahydrate Captafol (DifolataiV? ) - Skin 5 mg/nr 0.1 mg/m3 Cyanamide ,, Dioxathion (Delna\r^ - Skin 2 mg/nr 0.2 mg/m3 Dicrotophos (Bidrin') - Skin Endosulfan (Thigdan^) 0.25 mg/m3 0.1 mg/m3 Ethion (Nialat^) - Skin 0.4 mg/m Isophorone diisocyanate - Skin Methomyl (Lannat^'i Nudpin - Skin 0.01 ppm^ 2.5 mg/m Monocrotophos (Aaodriir^) m -Phthalodinitrile 0.25 mg/m 5.0 mg/m3 1,2-Propylene glycol dinitrate - Skin C 0,05 ppm Rubber Solvent 400 ppm 1,2,4-Trichlorobenzene C 5 ppm VM&P Naphtha 200 ppm Vinyl cyclohexene dioxide 10 ppm MINERAL DUSTS SUBSTANCE FROM 1974 TLV TO PROPOSED 1975 LIST Silica, amorphous, (including Diatomaceous earth) 20 mppcf 3 mg/m Total dust (all sampled sizes) 1 mg/m3 Respirable dust (< 5 pm) OLI 3799 NOTICE OF INTENDED CHANGES APPENDIX A CARCINOGENS The Committee lists below those substances in occupational use that have proven carcinogenic in man, or have induced cancer in animals under appropriate experimental conditions. Present listing of those substances carcinogenic for man takes three forms, those for which a TLV has been assigned (la), those for which environmental conditions have not been sufficiently defined to assign a TLV (lb), and lc, those whose reassign ment of a TLV is awaiting more definitive data, and hence should be treated as a lb carcinogen. la. Human Carcinogens. Substances, or substances associated with occupa tional processes, recognized to have carcinogenic or cocarcinogenic potential, with an assigned TLV. TLV Arsenic trioxide production AS2O3, 0.05 mg/m as As SO2, C 5.0 ppm Sb203, 0.05 mg/nr as Sb Asbestos, all forms* Cadmium oxide production bis (chloromethyl) ether Chromite ore processing Particulate Polycyclic Organic Matter 5 fibers/cc, < 5y in length 0,05 mg/nr* as Cd 1.0 ppb 0.1 mg/nr as Cr03 0.2 mg/m^, as benzene solubles ^Cigarette smoking may substantially enhance the incidence of broncho genic carcinoma from this and others of these substances or processes. *** lb. Human Carcinogens. Substances, or substances associated with industrial processes, recognized to have carcinogenic potential without an assigned TLV: 4-Aminodipheny1 (p-Xcnylamine) Benzidine production-Skin beta-Naphthylamine 4-Nitrodiphenyl lc. Human carcinogens. Substances with recognized carcinogenic potential awaiting reassignment of TLV pending further data acquisition: Vinyl chloride OLI 3800 2- - For the substances in lb, no exposure or contact by any route, respira tory, skin or oral, as detected by the most sensitive methods, shall be permitted. "No exposure or contact" means hermitizing the process or operation by the best practicable engineering methods. The worker should be properly equipped to insure virtually no contact with the carcinogen, A2. Occupational Substances Suspect of Oncogenic Potential for Workers. Chemical substances, or substances associated with occupational processes, which are suspected of inducing malignant neoplasms, based on either a) limited epidemiologic evidence, exclusive of clinical reports of single cases, or b) demonstration of malignant growths in one or more animal species by appropriate methods. Present evidence indicates that the assigned TLVs are below the threshold of response for inducing cancer in workers under ordinary conditions of employment. For those substances without an assigned TLV, exposure by all routes should be carefully controlled to levels consistent with the animal and human experience data (see Documentation). Substance or Operation TLV Benzo (a) pyrene*3)-Skin Beryllium3)*3) 3,3' Dichlorobenzidine^-Skin Dimethyl sulfate*3) Hydrazine*3^ -Skin 4, A'-Methylene bis (2-chloroaniline)*3 --Skin Nickel production (N^S^)3)**) Nitrosamines (Dimethyl nitrosamine)*3 Propane suit one*3) 2.0 yg/m3 C 1.0 mg/m^ 0.1 ppm 0.02 ppm Letters in parentheses refer to kinds of informational bases qualifying the substance or operation to be included in A2. (See Documentation) OLI 3801 ANNUAL REPORT, TLV COMMITTEE June 1975 OCCUPATIONAL SUBSTANCES UNDER SURVEILLANCE BY TLV SUBCOMMITTEE FOR ONCOOENIC POTENTIAL FOR WORKERS The substances listed below, although not presently qualifying for an A-2 listing,are being kept under continuing review by the 1LV Subcommittee. Chloroform Chloroprene Dieldrin-Aldrin 1,1-Dimethyl hydrazine Dioxane Epichlorohydrin Ethyleni.mine Lead chromate Methyl methacrylate Monomethyl hydrazine o-Toluidine Trichloroethylene Vinylcyclohexene dioxide OLI 3802 rune: or nr err.- ciialols (for l^?*1' m These piiysicinl agents, x itit ti>eir convsponding values, comprise those for which cither a licit has been prouosou for the first time, or for which a change in the "adopted" listing lias been proposed. Ir doth cases, tile proposed limits should bn considered trial limits that '-'ill remain in the 1 istir.<j for a poriue of at least one y.ar. If, after one year, no evidence cones to light that curstions the appropriateness of the values herein, the values '-ill be reconsidered for the; "adopted list. i (.`Tier or I--TD'T TO CSTf'PLISrl TI'hLSAOLO LiriT VALUES LIGHT Tliese Threshold Limit Valur. s refer tc visible radiation in the wavelength range of 4C0 nr.; to 70': nr and represent conditions under which it is believed that nearly all workers may be exposed without adverse effect. These values should be used as guides in the control of exposure to light and should not be regarded as a fine line between safe and dangerous levels. Recommenced Values. The Threshold Limit Value for occupational exposure to light '."here luminances arc known aim exposure 'orations exceeding 10 seconds in any eight tiour 'workday is as folic'S' 1. The average luninaucr of cljccts continuously viced shall not exceed 1 candela cm eg- /<_ This TLV is not to In used fer shed exposure ''orations or gulsec light sources. OLI 3803 T' `'r These ThroslTol ; Lir.ii Valur-s refer to sound pressure levels and orations of tx| osurc that myrt?sc-"L conditions u;n``'-r ch it is uc-lievod that noorly all rorkcrs ay :.c repeatedly exposen Htncut advorso effect on their ability to hear one- understand normal speech. The nodical profession has uefined hearing impairment as an average hearing threshold U-vcl in excess of 2b decibels (T'SI-bO.G-lff'O) at `TOO, 1000, and 2..000 h2, and the Units 'hico am riven have been established to prevent a hearing loss m excess of tin's level. The values shoulc be used as guides in tm control of noise exposure and, due to individual susceptibility, should not be regarded as fine lines between safe and dangerous levels. IbPULSIVL I1 TV'CT ilGISt It is recommended that exposure to impuslivt or impact noise should not oxceeu those listed in Table 11, Ingulsivi. or impact noise is considered to be those variations in noise levels that involve maxima at intervals of greater than one per second, '.'here the intervals are less tiian one second, it should he considered continuous. T/'.llf 11 ThflLShOLP LIT-IT V/U.UFS irpULSivf or-. 11'pact u'oisr Sound Level dB* 140 130 120 umber of Impulses or Impacts per day IT; icon 1GC00 ^decibels peak sound prrssum level OLI 3804 NOTICE OF INTENT TO CHANGE TLV for LASERS TLV's for Lasers would be changed for ocular exposure.to visible and IR-A laser radiation for durations greater than 10 s. Also to be changed would be TLV's for skin exposure to IR-A laser radiation. All other laser TLV's would remain unchanged. The sections of Tables 3, 4, and 6 that would have changes are as follows: Table 3 Changes Threshold Limit Values for Direct Ocular Exposures (Intrabeam Viewing) from a Laser Beam Spectral Wavelengths Region Exposure Duration (t) in Seconds TLV Light IR-A 400 nm to 700 nm 400 nm to 700 nm 400 nm to 550 nm 550 nm to 700 nm 550 nm to 700 nm 400 nm to 700 nm 700 nm to 1059 nm 700 nm to 1059 nm 1060 nm to 1400 nm 1060 nm to 1400 nm 700 nm to 1400 nm 10"9,ttio"1.8 x lO-5 5 X 10 7 J*cm 2 1.8 X 10"5 to 10 10 to 104 10 to T ! _2 10 mJ*cm 1.8^t//^*it^) mj*cm 2 T^ to 104 104 to 3 X 104 10"9 to 1.8 X 10"5 1.8 X 10~5 to 103 10-9 to 10-4 -4 3 10 to 10 103 to 3 X 104 10 qB M-cn'2 -2 Cg yWcm 5 C, X 10~7 J-cm'2 A 1.8 -cm 2 --6 --2 5 X 10 p*cm 9 (t./ ml cm 2 320 CA yW-cra-2 CA, - see Fig 2 of Permanent TLV listing for lasers CB = 1 fr X = 400 " nm to 550 nm; C = 10CO*O15(X B 550 nm)] . , ___ for X = 550-700 Tx = 10 s for X = 400-550 nm; t = 10 it 10 f *02 fX-550> 1 or X = 550 run to 700 nm. OLI 3805 2- Table 4 Changes Threshold Limit Values for Viewing a Diffuse Reflection of a Laser Beam or an Extended Source Laser Spectral Region Wavelengths Exposure Duration (t) in Seconds Light 400 run to 700 nm 400 nm to 550 nm 10~9 to 10 10 to 104 10/^t~ J*cm 2*sr ^ 21 J-cm *sr 550 nm to 700 nm 10 to T 3.83^t//^t) J*cm 2-sr IR-A 550 nm to 700 nm 400 nm to 700 nm 700 nm to 1400 nm T^ to 104 4 10 to 3 X io4 10~9 to 10 2 CB X 10-3 W-cm"2-sr-1 2c -3 -2 -1 X 10 W'cm -sr v*-- -2 -1 10 C, / t J*cm -sr 700 nm to 1400 nm 700 nm to 1400 nm 10 to 103 3 10 to 3 X 104 3.83 C /t/aVt^ J*cm 2*: 0.64 C W*cm-2 *sr-1 A c_A , B , and T\ 1 are the same as in footnote to Table 3 Spectral Region Wavelengths Table 6 changes Exposure Duration (t) in Seconds Light & IR-A 400 nm to 1400 nm "" 10~9 to 10~7 10'7 to 10 ' " 10 to 3 X 104 TLV 2 CA X 10 J'cm 1.1 J cm 0.2 CA W*cm_2 CA = 1,0 for ^ = 400-700 nm; see wavelength values. Figure 2 of Permanent TLV list for greater OLI 3806 -3NOTICE OF INTENT TO STUDY These agents comprise those which the Physical Agents Committee of ACGIB proposes to study during this year to determine the feasibility of establishing proposed TLV's in 1976. Comments and suggestions, accompanied by substantitive evidence, are solicited. Radiofrequency Radiation. Specifically, that of the spectrum from 10 MHz to 100 MHz. Ultrasonic Energy. Specifically, accoustic energy at frequencies above 10 kHz. Magnetic Fields. Both Pulsed and Contiuous. Microwave Radiation. Specifically from 100 GHz to 300 GHz. Laser Radiation. Specifically ultraviolet radiation atm for pulsed exposures, and repetitively pulsed Light and IR-A laser exposures. OLI 3807