Document npjYGV1GZZ7DeOQJ6n1nem528
* MCA NO. : VDC 1.3 - Tox - Orl - Dow
RESULTS OF A TWO-YEAR TOXICITY STUDY WITH VINYLIDENE CHLORIDE INCORPORATED IN THE DRINKING WATER OF RATS C. G. Humiston, J. F. Quast, C. E. Wade J. Ballard, J. E. Beyer, and R. W. Lisowe
Checked by: B. A. Schwetz
December 19, 1977
Toxicology Research Laboratory Health and Environmental Research
Dow Chemical U.S.A. Midland, Michigan 48640
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INTRODUCTION
Vinylidene chloride (VDC) is a liquid monomer of consid erable importance to the plastics industry. It is used in copolymers to manufacture various barrier resins and films widely used in industry and commerce. VDC exerts effects on the liver qualitatively resembling those of CC1^(1); how ever, its mechanism of action is apparently different and it seems to be metabolized to less toxic, rather than more toxic, metabolites. Effects on liver enzymes have been recorded at dose levels in the range of 100-800 mg/kg. Inhalation studies have indicated that VDC affects the central nervous system at high concentrations and the liver and kidney over a wider range of concentrations. To further establish the toxicological properties of vinylidene chloride and to determine its oncogenic potential, a series of toxicological studies have been initiated using various routes of exposure. The two-year study herein reported, wherein the vinylidene chloride was incorporated in the drinking water of rats, is one of the studies to evaluate the effects of chronic exposure by ingestion. Adminis tration of the test material in the drinking water was selected because the concentration of vinylidene chloride could be held relatively constant in water over a 24-hour period whereas it was rapidly lost from the feed.
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This study was conducted under the auspices of the Manu facturing Chemists Association and was financially supported by interested manufacturers and/or users of vinylidene chloride.
MATERIALS AND METHODS
Test Material. The vinylidene chloride used in this study
is described as follows:
chemical name: synonym:
molecular formula: structural formula:
molecular weight: description:
vinylidene chloride 1,1-dichloroethylene, VDC
C2H2C12 CH2 = ccl2 96.95 clear, colorless liquid having a characteristic sweet odor.
The VDC samples were aliquots of commercial production material, minimum purity 99.5%, obtained from The Dow Chemical Company, Freeport, Texas. The specifications for the pro duction material were as follows:
acetylenes acidity as HC1 water peroxides color APHA iron specific gravity at
25/25 C
25 ppm maximum 15 ppm maximum 75 ppm maximum 25 ppm maximum 30 maximum 0.5 ppm maximum
1.202 - 1.212
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polymer content ME HQ di-N-propylamine
free, clear 180 - 220 ppm 0.1 ppm maximum
Since the vinylidene chloride used to prepare various co polymers for food packaging applications is distilled to remove the MEHQ inhibitor, the VDC used in this study was distilled to bring the residual MEHQ into the range of 1-5 ppm,
A one-pint sample of the distilled VDC was kept in a freezer at minus 15-20C until used up or extensive polymerization had occurred, whereupon a fresh sample of the current dis tilled production material was obtained. Aliquots of most of these samples were submitted to the Dow Analytical Lab oratory for analysis. The samples were checked for their content of vinyl chloride, trans-1,2-dichloroethene, cis1,2-dichloroethene, 1,1,1-trichloroethane, 1,1,2-trichloroethane and MEHQ (monomethyl ether of hydroquinone) using a Dow standard gas chromatographic procedure.
Analysis of Drinking Water. Analyses of the daily pre parations of water solutions for their VDC content were conducted 16 times during the first 90 days of the study then 19 times at periodic intervals during the remainder of the test period.
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The water solutions were analyzed using a gas chromatograph under the following conditions:
Column: Oven Temperature:
Detector: Carrier gas:
Flow rate: Attenuation: Sample Volume:
1/4" Porapak Q, 80-100, 6 ft. 180C dual flame ionization helium 20 ml/min. 80 4-5 vi 1 (normalized to 1 yl)
The chromatograms obtained were compared with those from standard solutions of vinylidene chloride to determine the concentrations in the test solutions.
The means S.D. of these analyses were 68+21 ppm, 99+22 ppm, and 206+33 ppm for the respective nominal intended concen trations of 50, 100 and 200 ppm VDC.
General Design.' The design of this 2-year study is indicated in tabular form below.
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Design of the 2 Year Study Incorporating Vinylidene Chloride in the Drinking Water of Rats
Number of Rats:
Dose Levels: Equivalent Range:
80/sex for controls 48/sex/dose level of VDC1
50, 100, 200 ppm (nominal)
5-12, 8-20, 16-40 mg/kg/day2
Parameter
Hematology* Urinalysis* Clinical Chemistry** Necropsy Ophthalmologic Exam Organ Weights Histopathology
180
XXX XXX XXX
Days on Test 365 540
XXX XXX XXX
XXX XXX XXX
s abbbaa
*5/sex/group **5/sex/group at 180, 365 and 540 days (orbital bleeding) and
10/sex/group at 730 days.
^ne male rat in the 200 ppm dose level was lost sometime between days 624 and 652 and is therefore excluded from the pathology data. As of day 624 this rat did not show any evidence of tumor formation or other adverse effects.
2Dosages selected approximate 5,000-12,000, 8,000-20,000 and 16,00040,000 times the amount of vinylidene chloride that would be ingested by a 75 kg person on a daily diet of 1,500 grams, assuming all the food was contained in food packages containing the compound and mi gration was 50 ppb into the food.
Sprague-Dawley, Spartan substrain, SPF-derived rats, 6-7 weeks old, were used in this study. The rats were randomly housed in suspended wire-bottomed cages with two rats per cage and
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then grouped as indicated for the various treatments. Food (ground laboratory chow, Ralston-Purina Co.) and water were available ad libitum. Water was supplied from glass bottles with specially devised plastic screw caps fitted with stain less steel sipper tubes containing stainless steel balls. The bottles were emptied and refilled each day from freshly prepared stock solutions. Because of the volatility of VDC, the concentrations of the stock solutions were made up to exceed the nominal concentrations so that the mean levels during the 24 hours would be as near as possible to the nominal treatment concentrations.
Observations and Records. The rats were observed at least twice weekly for signs of toxicity and evidence of tumor formation. Food consumption was recorded twice weekly for the animals in 5 cages/sex/group for the first 3 months of the test and then for 25 cages/sex for the controls and 14 cages/sex/treatment level 2 times during one week per month for the remainder of the study in so far as the number of surviving animals would permit. Water consumption, for the animals in the same cages for which food consumption was recorded, was determined daily for the first 3 weeks, then 2 times per week for the next 12 weeks, and twice during one week of each month thereafter. Body weights were recorded weekly for the first 14 weeks and then monthly thereafter.
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Clinical Studies. Hematological studiesa, including deter minations of packed cell volume (PCV), erythrocyte count (RBC), hemoglobin concentration (Hgb), total (WBC) and differential leucocyte counts, were conducted on days 181-2, 365, 540 and 701-2 on blood samples from at least 5 rats/ sex/group. Urine samples were obtained from these same rats at the time that the hematological samples were taken. Urinalyses*3 that included determination of specific gravity, pH, sugar, protein, ketones, occult blood and bilirubin were run on the urine samples.
Clinical chemistry studies were conducted on blood collected by orbital sinus puncture from 5 rats/sex/group on days 181, 184, 366, 541, and from 10 rats/sex/group on day 707. These determinations were also conducted on blood samples obtained at the necropsy on days 730 and 731 from 10 rats/ sex/group or from all survivors for those groups having less than 10 animals remaining. The clinical chemistry parameters0
PCV-Microhematocrit Centrifuge, Clay-Adams Company, New York; RBC, WBC counts, Hgb - Coulter Counter Model 2B1 and hemoglobinometer, Coulter-Electronics, Hialea, Florida. ^Specific gravity - T.S. Meter, American Optical Company, Buffalo, New York; pH, sugar, protein, ketones, bilirubin, and occult blood Bililabstix, Ames Company, Elkhart, Indiana. CBUN, AP, SGPT and Glucose - AA Methods File N-IC, AAII-06, AAII-22 and N-2B respectively, Technicon Instruments Corporation, Tarrytown, N.Y.
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evaluated included blood urea nitrogen (BUN), serum alkaline phosphatase activity (AP), serum glutamic pyruvic transaminase activity (SGPT), and glucose concentration.
Necropsy and Pathology. During the 24 month experimental period every effort was made to examine and select the rats for submission to autopsy prior to their natural death so as to minimize the amount of postmortem autolysis. Whether the rats died spontaneously, were selectively culled from the study, or killed at termination of the study, a complete gross pathologic examination was performed and tissues were saved in buffered 10% formalin. Histologic examination of tissues was conducted to evaluate the probable cause of death, to establish the cause of the clinical appearance used as a basis to cull the rat, and to evalute chronic toxicity changes and any tumor-like process.
At termination of the study, 730 days for females and 731 days for males, all rats were fasted overnight prior to autopsy. A fasting body weight was taken prior to killing the rats by decapitation. Organ weights of brain, heart, liver, kidney, and testes were measured. A complete set of the following tissues, whenever possible, was saved in buffered 10% formalin from the rats which died spontaneously, were selectively culled, or were alive at termination of the study.
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REPRESENTATIVE TISSUE SPECIMENS OBTAINED AT AUTOPSY FROM ALL ANIMALS
esophagus
salivary glands stomach
large intestine
pancreas
liver
kidneys
urinary bladder prostate
accessory sex glands
epididymides
testes
ovaries
a
oviducts
uterus
mammary tissue (females) r cerebrum
brain
< cerebellum ^ brain stem
pituitary gland
spinal cord
peripheral nerve trachea lungs (bronchi)
nasal turbinates sternum and sternal
bone marrow*3
spleen mediastinal lymphoid tissue3
(thymus, mediastinal lymph nodes)
lymph nodes (mesenteric) heart aorta skeletal muscle adrenal glands thyroid gland parathyroid gland3
adipose tissue skin any gross lesion or mass
aThese tissues were evaluated histologically only to the extent that they were included in the routine sections of adjacent larger organs.
Sternum and enclosed bone marrow were to be evaluated histologically only if indicated by abnormal findings in the hematological studies.
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The formalin-fixed tissues were prepared by routine histolo gical procedures. They were embedded in embedding medium, sectioned (5-6 y), and stained with hematoxylin and eosin for evaluation by light microscopy. Whenever necessary for differential diagnosis of selected tissues, special staining procedures were used according to those outlined in the AFIP manual on histological techniques (2). Histologic exami nation was made of complete sets of tissues, whenever possible, from control and top dose rats. Selected target organs and grossly recognized tumorous changes in animals of the middle and low dose groups were also examined microscopically. The number of organs and tissues prepared and examined by light microscopy from the various dose levels are presented in Tables 15 and 20 for male and female rats, respectively. All tumor or tumor-like lesions recognized at autopsy and recognizable in formalin-fixed tissues were specifically selected for histopathologic evaluation. In addition, the tissues listed in Tables 15 and 20 were evaluated for chronic pathologic alterations to ascertain whether a treatment related effect was present.
Statistical Evaluation of Data. Hematology, clinical chem istry, food consumption, water consumption, body weight and organ weight data were evaluated statistically using an analysis of variance with the treatment means being compared
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to the control means using Dunnett's test (Steel and Torrie, 1960) (4). The mortality data were analyzed using the Fisher Exact Probability Test (Siegel, 1956) (3) . The Fisher Exact Probability Test was also used to evaluate the significance of differences in the incidence of tumorous and non-tumorous lesions between groups and sexes. Statistical evaluations of the microscopic observations for animals of the 50 and 100 ppm treatment groups were performed only when the number of tissues examined were comparable to those in the 200 ppm and control groups. The statistical evaluations of the pathologic observations were performed on the total cumulative values for the respective observations. The level of significance chosen for all cases was p<0.05.
RESULTS AND DISCUSSION
General Observations. The appearance and demeanor of the rats ingesting vinylidene chloride in their drinking water was not different from that of the controls throughout the study. The cumulative mortality is summarized in Figures 1 and 2 and in Tables 1 and 2. Mortality was significantly different from controls only at 22 months for the male rats on water containing 100 ppm VDC, and during the 24th month for the male rats on the 50 ppm level. There were no significant differences in mortality for any treatment
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group, male or female, at any other time during the study.
Body Weights. Body weight determinations are summarized in Tables 3, A-l, and A-2. Body weight gains were similar for groups of treated rats and controls, with no dose related differences to suggest an effect of treatment.
Food Consumption. Food consumption data are summarized in Tables 4, A-3, and A-4. Only sporadic differences between treatment groups and controls were noted on occasion during the study, which were not dose related and appeared to be unrelated to VDC consumption. There were increases and decreases in food consumption, but no trends in either direction and no correlations with either dose or time on study.
Water Consumption. Data on water consumption are summarized in Tables 5, A-5, and A-6. The sporadic differences in water consumption occurring on occasion throughout the study were not dose-related or time-dependent and were considered to be unrelated to the concentration of VDC present. Both increases and decreases in consumption were found but with no trend in either direction.
Clinical Studies Hematology. Results of hematologic studies are summarized
*
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in Tables 6, A-7, and A-8. The statistically significant increase in WBC on day 181 for the male rats and the in creased hemoglobin value on day 540 for the female rats, both on water containing 50 ppm, were considered to have no toxicological significance since the responses were not dose-related and were within the range of normal values for these parameters as determined in this laboratory for this strain of rat. No other statistically significant differences from control were observed.
Urinalyses. Summaries of the urinalyses are shown in Tables 7, 8, A-9, and A-10. The statistically significant increase in specific gravity on day 701 for the females on water containing 100 ppm was considered to be unrelated to treatment and of not toxicological significance. The value determined is well within the normal range for this strain of rat as determined in this laboratory. All other determinations indicated no differences between the animals on treatment and their corresponding controls.
Clinical Chemistry. The clinical chemistry parameters evaluated at six months, one year, 18 months, and 24 months are summarized in Tables 9 and A-ll. The increased alkaline phosphatase activity evident in the high dose females at 181 days probably resulted from the fact that the rats were not
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fasted overnight before taking the blood sample sines it was not evident 3 days later when the test was repeated . n. blood from fasted animals. The statistically significant increase in BUN in the male rats on day 181 and 184 was within the normal range for this strain of rat and was not considered to be toxicologically significant. The increase noted in the BUN determination for the male rats of the 50 ppm group on day 707 was probably not due to ingestion of VDC since it did not occur in animals receiving higher levels of VDC. In addition, the increase was evident only in 3 out of the 9 animals of the group and is within the normal range for this strain of rat at this age.
Organ Weights. The mean organ weights, fasted body weights and organ to body weight ratios are summarized in Tables 10, A-12 and A-13. There were no significant differences in any of the means for the treatment groups when compared with the mean values for the corresponding control animals.
Pathology. The gross and histopathologic observations of
nontumorous chronic pathologic lesions and those of a
tumorous nature are presented in Tables 11 to 15 (males) and
16 to 20 (females). For easy reference to the pathologic
observations the f^
.lng is a list of these tables.
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Table 11 Nontumorous gross pathologic lesions in male rats. Table 12 Nontumorous histopathologic lesions in male rats. Table 13 Tumor or tumor-like lesions grossly recognized in
male rats. Table 14 Histopathologic diagnosis and number of tumors in
male rats. Table 15 Number of male rats for which the specified tissue
was examined microscopically. Table 16 Nontumorous gross pathologic lesions in female rats. Table 17 Nontumorous histopathologic lesions in female rats. Table 18 Tumor or tumor-like lesions grossly recognized in
female rats. Table 19 Histopathologic diagnosis and number of tumors in
female rats. Table 20 Number of female rats for which the specified tissue
was examined microscopically.
A large number of gross and microscopic lesions were re corded for the control and test rats. These lesions included the normal spectrum of spontaneously occurring age-related changes usually encountered in lifetime studies with this strain of rat. Statistical evaluation of the gross pathologic and histopathologic data revealed occasional observations which occurred statistically more or less frequently in a treatment group than in the respective control group. Ob servations that were statistically significantly different from the controls were as follows:
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*
1. Decreased incidence of small white foci in the liver in 100 ppm male rats (Table 11).
2. Decreased incidence of red subcapsular foci in the liver in 100 ppm male rats (Table 11).
3. Decreased incidence of diffuse darkened areas through out the lung in 200 ppm male rats (Table 11).
4. Increased incidence of renal cysts not directly identi fied with chronic renal disease in 50 ppm male rats (Table 11) .
5. Increased incidence of moderate to severe depletion of adipose tissue within the abdominal cavity in 50, 100, and 200 ppm male rats (Table 11).
6. Increased incidence of the gastrointestinal tract being devoid of feed or feces in 100 and 200 ppm male rats (Table 11).
7. Decreased incidence of centrilobular hepatocellular atrophy in 50 ppm male rats (Table 12).
8. Decreased incidence of hepatocellular atrophy without fatty change in 200 ppm male rats (Table 12).
9. Increased incidence of periportal hepatocellular hypertrophy in 200 ppm male rats (Table 12).
10.
Increased incidence of hepatocellular atrophy with fatty change in 200 ppm male rats (Table 12).
11.
Increased incidence of centrilobular hepatocellular fatty degeneration in 200 ppm male rats (Table 12).
12.
Increased incidence of the total number of rats with hepatocellular fatty change or fatty degeneration in 200 ppm male rats (Table 12).
13.
Decreased incidence of focal subepithelial mononuclear inflammatory cell infiltrate in the trachea of 50, 100, and 200 ppm male rats (Table 12).
14. Decreased incidence of focal alveolar histiocytosis in lungs of 100 and 200 ppm male rats (Table 12).
15. Increased incidence of focal atrophy of the panc_ acinar tissue in 50 ppm male rats (Table 12).
ic
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16.
Increased incidence of a minimal degree of focal myo cardial degeneration and fibrosis in 200 ppm male rats (Table 12).
17.
Decreased incidence of a severe degree of focal myo cardial degeneration and fibrosis in 200 ppm male rats (Table 12).
18.
Increased incidence of atrophy of mediastinal adipose tissue in 100 ppm male rats (Table 12).
19. Increased incidence of atrophy of the mediastinal lym phoid tissue in 50 ppm male rats (Table 12).
20. Increased incidence of atrophy of the mesenteric lymph nodes in 200 ppm male rats (Table 12).
21. Decreased incidence of pancreatic nodules in 100 ppm male rats (Table 13).
22. Increased incidence of decreased size of liver in 200 ppm female rats (Table 14).
23. Decreased incidence of red subcapsular foci in the liver in 50, 100, and 200 ppm female rats (Table 16).
24.
Increased incidence of moderate to severe depletion of adipose tissue within the abdominal cavity in 200 ppm female rats (Table 16).
25. Increased incidence of centrilobular hepatocellular atrophy in 200 ppm female rats (Table 17).
26. Increased incidence of periportal hepatocellular hy pertrophy in 100 and 200 ppm female rats (Table 17).
27.
Increased incidence of hepatocellular fatty change with location in lobule not specified in 50, 100, and 200 ppm female rats (Table 17).
28. Increased incidence in periportal hepatocellular fatty change in 200 ppm female rats (Table 17).
29.
Increased incidence in the total number of rats with hepatocellular fatty change or fatty degeneration in 50, 100, and 200 ppm female rats (Table 17).
30. Decreased incidence of focal vascular sinusoid dilatation in the liver of 50 and 100 ppm female rats (Table 17).
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31.
Decreased incidence of focal subepithelial mononuclear inflammatory cell infiltrate in the trachea of 100 ppm female rats (Table 17).
32.
Decreased incidence of multifocal mononuclear cell infiltrate in the kidneys of 50 ppm female rats (Table 17) .
33.
Decreased incidence of focal granulomatous inflam mation without a foreign body present in the tongue of 200 ppm female rats (Table 17).
34.
Increased incidence of a minimal degree of focal myo cardial degeneration and fibrosis in 50 ppm female rats (Table 17) .
35. Increased incidence of hematocyst formation of the adrenal cortex in 100 ppm female rats (Table 17).
36.
Increased incidence in pituitary gland adenoma in 50 ppm female rats (Table 19).
Of the statistically significant deviations observed in this study, only those affecting the liver were considered treat ment related. The hepatic treatment-related lesion recognized only upon microscopic examination of the liver was charac terized by fatty change or fatty degeneration. This change was found in female rats of the 50, 100 and 200 ppm groups, and in males of the 200 ppm group. Although the incidence of the liver lesion in the males in the 100 ppm group was not statistically significantly increased, a trend towards an increased incidence was observed. No treatment-related liver lesions were recognized in the 50 ppm group of male rats. Additional microscopic hepatic lesions that were seen
>
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in treated rats with an increased incidence were characterized by centrilobular hepatocellular atrophy or periportal hepato cellular hypertrophy. Treatment-related hepatocellular necrosis was not a significant finding in either male or female rats.
The presence of the other statistically significant deviations were considered within the normal variation encountered in lifetime studies with this strain of rat. The high incidence of spontaneously occurring advanced chronic renal disease in male rats of this strain is the primary cause for their spontaneous death or reason for being culled from the study (Table 12). Most of these rats also exhibit other chronic organ system lesions associated with the chronic renal failure and a uremic state.
The female rat of this strain has a high spontaneous inci dence of subcutaneous masses involving mammary tissue and changes in the endocerine glands. Both of these changes contribute to the death of these animals or their being culled from the study. The number, location, and size of the masses in the mammary region frequently results in pressure necrosis, ulceration, and subsequent hemorrhage that may result in death. Secondary changes related to hemorrhage and anemia are frequently seen in the heart,
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lungs, liver and spleen of rats which do not die acutely due to blood loss.
In view of the incidence of the nontumorous spontaneously occurring lesions in this study and in other lifetime studies of this rat strain, the occasionally observed statistically significant deviations, other than in the liver, were not considered treatment related.
Evaluation of the tumor data reveals no statistically significantly increased or decreased incidence for any type of tumor in male rats (Table 14). In the females the only statistically significant deviation in tumor incidence involved the pituitary gland. Pituitary gland adenoma was found in the 50 ppm group at a significantly increased incidence. Because of the variable incidence of this tumor and its presence only in the lowest treatment group rather than the highest treatment group, it was not considered treatment related (Table 19). The chronic hepatocellular lesions observed in this study did not result in a tumorigenic effect in the liver as is evidenced in Table 14 (males) and Table 19 (females).
The total incidence of histopathologically diagnose^, plasms, benign plus malignant, derived from Table 14 (maies)
>
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and Table 19 (females) is as follows:
Concentration of VDC in water (ppm)
0 50 100 200
Total Number of Neoplasms
Male
Female
128 186 65 131 54 116 68 124
Total Number Rats in Group
Male
Female
80 80 48 48 48 48 47 48
Average Number of Neoplasms/rat in Group
Male
Female
1.6 1.4 1.1 1.4
2.3 2.7 2.4 2.6
It is evident from the tumor data presented in these tables that no target organ was found that showed a tumorigenic effect which was considered treatment related. In addition. the total tumor incidence in male and female rats in the various treatment groups was not considered different than in the controls.
SUMMARY AND CONCLUSIONS
In this 2-year study with rats maintained on drinking water containing vinylidene chloride there were no significant differences between the treatment groups and the corresponding control groups in the following parameters: appearance and demeanor, mortality, body weight, food consumption, water consumption, hematology, urinalysis, clinical chemistry determinations, organ weights and organ to body weight
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ratios. Gross pathologic and histopathologic observations showed both increases and decreases in the incidence of various nontumorous lesions in both sexes. Of the statis tically significant deviations that were seen, only those affecting the liver were considered to be treatment-related. The treatment-related lesion of the liver, evident only upon microscopic examination, was characterized by fatty change or fatty degeneration. It occurred in the females at all dose levels and in the males only at the high dose level, with a similar trend in the 100 ppm males which was not statistically significant. However, treatment-related hepatocellular necrosis was not a significant finding in either male or female rats and there was no evidence that these lesions resulted in a tumorigenic effect in the liver. All other statistically significant deviations were con sidered to be within the normal variation encountered in lifetime studies with this strain of rat.
The only statistically significant tumorous changes detected, i.e., the decrease in pancreatic nodules in male rats of the 100 ppm treatment level and the increase in pituitary adenomas in the females of the 50 ppm treatment level, were considered to be not treatment related.
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The total tumor incidence in male and female rats in the various treatment groups was not different than in the controls. Furthermore, no target organ was found that showed a treatment-related tumorigenic effect. Thus, the results of this 2-year study do not indicate an oncogenic effect for vinylidene chloride ingested by rats.
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REFERENCES
(1) Confidential survey by Christine C. Rostron.
(2) Manual of Histologic Staining Methods of the Armed
Forces Institute of Pathology, Third Edition (1960),
Edited by Lee G. Luna, HI(ASCP), McGraw-Hill Book
Company, Inc., New York, N.Y.
*
(3) Siegel, S. (1956). Non-Parametric Statistics for the
Behavioral Sciences, McGraw-Hill Book Company, Inc.,
New York, N.W.
(4) Steele, R.C.D. and Torrie, H. H. (1960). Principles
and Procedures of Statistics, McGraw-Hill Book Company,
Inc., New York, N.Y., pp. 101-112.
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Written By:
C. G. Humiston, Ph.D. Research Specialist Toxicology Research Laboratory
J. F. Quast, D.V.M., Ph.D. Diplomate, American College of
Veterinary Pathologists Research Specialist, Pathologist Toxicology Research Laboratory
0. . bOcdi_____________________
C. E. Wade Research Biologist Toxicology Research Laboratory
JT.V BDaal l1lard, TH.T. (ASCP) Histologist Toxicology Research Laboratory
U .
____________________________
E. Beyer/'B.S. Medical Technologist Toxicology Research Laboratory
*2. SU
____________________
R. W. Lisowe, H.T. (ASCP) Research Histologist Toxicology Research Laboratory
Approved By:
fZA S
B. A. Schwetz, D.V.fif. , Ph.D. Research Manager Toxicology Research Laboratory
Date: ' "2- ' ,0> - 77 Date: /9 fUc. 7?
Date: }. ~ lj - 77
Date:
7/
Date:
-S?- jp
Date; A#-/?-77
Date:
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Figure 1 Tto3 Q0)
Days on Test
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100
Figure 2
MORTALITY - FEMALES
80 < 0-0 Control + ** + + 50 ppm
o ocad) 6^
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Days on Test
TABLE 1
Cumulative Mortality Data of Male Rats Maintained For 2 Years On Drinking Water Containing Vinylidene Chloride
Months on Study
No. of Rats on Day 0
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
Control No. Dead (X Dead)
80
0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 1 (1.3) 2 (2.5) 2 (2.5) 2 (2.5) 2 (2.5) 2 (2.5) 4 (5.0) 4 (5.0) 4 (5.0) 7 (8.8) 13 (16.3) 15 (18.8) 18 (22.5) 20 (25.0) 26 (32.5) 39 (48.8) 44 (55.0) 56 (70.0) 61 (76.3)
50 ppm No. Dead (% Dead)
48
0 (0) 0 (0) o (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 2 (4.2) 2 (4.2) 3 (6.3) 7 (14.6) 9 (18.8) 13 (27.1) 14 (29.2) 15 (31.3) 23 (47.9) 30 (62.5) 33 (62.5) 39 (81.3) 43 (89.6)*
100 ppm No. Dead (X Dead)
48
0 (0) 0 (0) 0 (0) 0 (0) 1 (2.1) 1 (2.1) 1 (2.1) 1 (2.1) 1 (2.1) 2 (4.2) 3 (6.3) 3 (6.3) 3 (6.3) 4 (8.3) 5 (10.4) 6 (12.5) 11 (22.9) 13 (27.1) 19 (39.6) 23 (47.9) 31 (64.6) 35 (72.9)* 36 (75.0) 40 (83.3)
200 ppm No. Dead (% Dead)
48
0 (0) 0 (0) 1 (2.1) 1 (2.1) 2 (4.2) 2 (4.2) 2 (4.2) 3 (6.3) 3 (6.3) 4 (8.3) 4 (8.3) 5 (10.4) 6 (12.5) 6 (12.5) 6 (12.5) 12 (25.0) 12 (25.0) 15 (27.1) 16 (33.3) 20 (41.7) 27 (56.3) 30 (63.8) 26 (76.6) 38 (80.9)
*Significantly different from the control by Fisher s Exact Probability test, p<0.05.
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TABLE 2
Cumulative Mortality Data of Female Rats Maintained For 2 Years On Drinking Water Containing Vinylidene Chloride
Months on S tudy
No. of Rats on Day 0
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
Control No. Dead a Dead)
80
0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 1 (1.3) 1 (1.3) 1 (1.3) 1 (1-3) 1 (1.3) 1 (1.3) 1 (1.3) 3 (3.8) 5 (6.3) 9 (11.3) 12 (15.0) 15 (18.8) 18 (22.5) 22 (27.5) 38 (47.5) 44 (55.0) 48 (60.0) 57 (71.3)
50 ppm No. Dead (% Dead)
48
0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 1 (2.1) 1 (2.1) 1 (2.1) 1 (2.1) 5 (10.4) 5 (10.4) 8 (16.7) 11 (22.9) 16 (33.3) 19 (39.6) 22 (45.8) 30 (62.5)
100 ppm No. Dead (% Dead)
48
0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 1 (2.1) 1 (2.1) 1 (2.1) 1 (2.1) 3 (6.3) 3 (6.3) 4 (8.3) 4 (8.3) 6 (12.5) 7 (14.6) 7 (14.6) 7 (14.6) 8 (16.7) 9 (18.8) 18 (37.5) 19 (39.6) 24 (50.0) 31 (64.6)
200 ppm No. Dead (% Dead)
48
0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 1 (2.1) 4 (8.3) 7 (14.6) 10 (20.8) 12 (25.0) 16 (33.3) 18 (37.5) 19 (39.6) 23 (47.9) 32 (66.7) 33 (68.8)
SL 081995
SL 081996
TABLE 3
MEAN BODY WEIGHTS3 FOR MALE AND FEMALE RATS MAINTAINED ON DR INK I NO WATER CONTAINING VI NY II DENE CHLORIDE FOR 730(F) AND 731(M) DAYS
Days on Tes c
0 7 14 21 28 35 42 49 56 63 70 77 84 91 97 100 139 181 210 238 266 294 330 357 38 5 413 441 469 472 497 533 568 596 624 652 689 715 729
249 + 12
307 t 15 348 + 12 371 + 15 392 + 16 408 + 20 420 + 14 429 + 20
436 + 19 450 + 21 458 + 25 463 + 31
457 48 484 + 28 487 + 32
468 41 511 + 44 540 + 46
548 + 51
569 + 52 577 + 56 592 + 57 592 + 58
604 61 607 + 61 615 + 72
624 58 619 + 62 625 + 61 633 + 58 618 + 60 615 + 65 621 + 81 610 + 59 617 + 57 586 + 54 566 + 44 563 + 58
MALES 50
100
255 t 18 305 20 346 21 372 + 29 394 + 34
389 18 416 + 33 433 + 35
443 + 38 456 + 40
463 40 472 + 38
477 t 44 485 + 36
480 46 468 + 39
526 * 40
537 45
555 47
561 + 47 578 + 49 579 + 49
587 + 51 594 + 49 591 + 48
606 50 611 + 48 617 + 44 602 51
602 58* 602 49 588 82 581 + 63
588 61 588 + 45 562 + 26 514 + 83 560 + 48
258 11 319 + 9
368 12 390 + 27 424 + 18 442 + 19 454 + 20 473 + 26 482 + 21* 493 + 25
496 31 504 + 31 500 + 34 516 + 33
519 + 32
480 + 51
543 + 59 549 + 58 566 t 57 569 + 58 592 + 61 594 + 58 603 + 53 607 + 55 606 + 50 610 + 56 612 +; 55 609 51 603 68 608 + 65
596 56 591 + 60 593 + 69 586 + 73 600 + 84 581 + 84 53 5 + 123 551 + 107
Dose Level (ppm)
200
254 + 15 307 + 18 349 + 19 373 + 20 398 + 21 410 * 24
418 27
436 t 25 444 + 27 4 50 + 25 437 + 56 469 + 25 469 + 30
484 1 27 498 + 20
479 42 529 + 44 549 1 51 550 + 51
574 t 51
574 52 596 63 602 +; 56 622 + 61 615 + 58 624 + 61 616 61 612 55 618 + 69 628 + 57 609 + 56 588 + 73 583 + 83
590 67
589 57 584 + 77 554 + 80 566 + 74
199 + ii 222 + 10
243 14 255 + 15
268 14 271 + 15 276 + 13
284 i 15 285 + 15 291 + 22
297 13 300 + 15 304 + 13 307 + 14 318 + 16 296 + 21
322 23
329 26 334 + 25
341 + 27 352 + 28 351 + 29 3 57 + 32 356 + 47 362 + 36
374 + 43 379 + 44
391 50 386 + 50 393 + 62 370 + 80
410 73 426 + 94 417 + 86 421 + 83 419 + 82
401 88 412 + 79
FEMALES 50 100
18 9 + 5
21 2 7 , +8
237 + 8 252 + 7 250 + 14
246 t 25 25 5 + 30 271 + 6 270 + 20 279 + 10 282 + 10 268 + 9*
289 10 286 +- 19* 291 + 17 317 + 23 320 + 19 332 22
339 + 22 347 + 2b 346 + 24 3 53 + 26
354 30 361 + 48
368 39
374 47 404 + 61 381 + 55 38 2 + 54 383 + 43 394 + 47 404 t 76 415 + 72 419 t 77
41 5 79 384 + 66
400 78
191 + 12 213 + 9 236 t 13 235 + 11* 254 + 14 257 + 16 262 + 13 270 + 18 274 + 18 277 + 18 281 + 17 282 + 15 273 + 21* 279 + 14* 290 + 21 291 + 18 314 + 15 321 + 24 329 t 24
339 + 26
349 29
351 4 6
352 I 30
353 30 354 + 33
364 + 34
363 + 35 386 42
367 t 38
373 42 378 + 48
391 t 59
4 14 + 9b 407 1 61
41 7 i 76 422 * 90
403 94 432 t 110
'Each value represents mean + S.D. for a minimum of 5 animals in the first 100 days and all anicaal^, thereat ter . *Statistical 1 y significantly different, from control mean by Ounnutt's test, p<0.05.
200
190 12 217 7 240 9 251 10 263 8 266 10 269 12 278 12 279 11 288 10 291 11 297 + 11 298 8 305 11 310 13 289 + 19 322 17 322 24 324 24 333 22 342 27 345 29 356 t 37 358 37 360 45 375 52 378 48 388 49 380 51 389 62 391 69 389 67 411 + 97 413 60 422 + 80 433 88 450 t 104 444 + 98
TABLE 4
MEAN DAILY FOOD CONSUMPTION- IN GRAMS/RAT/DAY OF MALE AND FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 730(F) OR 731 (M) DAYS*
Days on Test
G-J 3-7 7-10 10-14 14-17 17-21 21-24 24-28 28-31 31-35 35-33 38-*2 42-4 5 4d-49 49-32 52-56 36-59 59-63 63-66 66-70 70-73 -3-77 77-80 80-64 34-8 7 87-91 91-94 94-98
101-105 105-108 140-1-3 ]4j-i47 175-178 178-L32 206-210 210-213 234-218 238-241 262-266 266-269 290-294 294-297 325-330 330-332
331-385 385-388 4 06-h09 409-413 448-4S1 451-455 469-472 472-476 498-500 500-504 532-535 535-539 546-549 563-567 595-598 623-626 651-654 686-689 714-717
_______ _Males
0
24 - 1 27 t 2 26 2 28 s 1 27 ; 2 27 f 2
26 3 27 ; 2b 3 26 t 2 25 ; 1 27 3 25 1 28 6 21 4 24 z 3 28 2 26 2 30 9 28 2 21 2 27 3 26 2 27 3 26 t 2 27 * 2 26 > 26 1
'4 4
25 2 23 3 24 4 26 7 23 1 24 1 24 1 24 2 26 2 25 2 25 2 24 2 25 2 26 2 29 *
25 2 25 3 25 * 5 27 2 26 3 26 3 23 3 24 5 26 2 25 + 2 25 3 25 + 2 22 * 5 23 3 22 3 27 7 23 4 24 4 25 1 4
Dose Levels (ppm)
_______________________________________________ _
____ _____________________
50
100
200
c) 50
Females
25 I 2 26 t 2 26 : 2 27 t 2 26 t 3 25 t 2 ,0 3 26 3 27 4 24 1 57 5 24 : 1 23 10 27 4
26 3 25 3 26 8 25 4 24 6 28 3 25 5 24 2 25 5 . 28 4 27 5 26 2 25 3 25 -
25 , j 28 ; 2 28 1 29 1 29 1 27 2 29 i 28 1 28 1 29 1 27 2 29 1 11 4 28 2 27 1* 26 1 27 6 27 1 26 1 28 * 1 28 5 27 1 26 1 28 1 26 l 27 1 26 1
26 1
25 , 1 26 i 2 25 3 11 3 21 3 26 3 25 3 25 3 25 - 3 26 2 29 * 4 26 3
25 * 1 25 3 24 3 20 3 27 2 25 - 3 23 3 24 2 25 1 24 5 25 2 26 2
24 1 2
25 2 18 2* 23 s 2
19- 1 21 2 20 l 20 2 20 1 21 2 19 2 20 1 20 l 20 1 20 2 21 1 19 1 20 1 20 2 18 4 21 2 23 5 22 2 21 1 20 2
20 1 21 * 1 22 2 23 2 20 1 21 1
20 1
20 . 2 20 2 18 1 18 2 20 1 19 2 19 2 20 1 22 * 6 19 l 19 6 20 2 24 4 22 4 22 5 20 5 19 1 20 2 20 2 21 3 19 10
20 5
20 1 25 3 20 3 20 1 20 2
20 * 1
100
21 3 22 * 2 19 * 1 19 r 1 18 i 2 19 1 19 t 2 19 I 1 19 2 19 1 18 1 19 2 18 1 20 1 2 19 2 18 4 17 4 21 3 21 1 21 L 20 2 19 1 20 2 22 1 19 1 19 + 1 21 6 20 3
25 4 25 3 25 L 25 2 26 2 2* 2 25 2 25 2 24 2 26 2 27 l 25 5 25 1 25 2 26 2 33 t 4
26 25 3 24 3 25 4 27 6 25 4* 26 4* 27 4* 26 3* 21 3 28 2* 27 2 24 3 24 * 4 29 9 34 4
24 * 5 23 4 23 2 23 2 24 4 23 2 25 2 25 2 25 2 26 2 26 2 26 3 24 4 25 2 26 2
31 : 5
19 * 2 19 2 19 2 19 1 20 4 19 3 19 2 20 3 20 3 21 4 22 5 21 2 19 2 19 2 20 2
21 3
20 3 20 2 19 3 19 2 19 2 18 2 18 2 20 3 19 4 27 4* 20 1 19 l 3 19 2 18 2 21 3
22 * 5
19 3 20 3 18 2 18 2 19 2 18 2 18 2 19 2 19 2 21 4 22 2 20 3 18 3 21 3 19 3 24 i 7
25 - 4
27 5 25 7 28 2 29 3* 28 3 26 5 25 3 26 6
25 3 25 4 26 3 26 - 4 22 5 21 5 28 4 22 + 8 26 5 23 6
26 3 25 3 24 6 25 5 27 2
27 3 24 5
26 4 28 4 26 3 24 5 22 4 26 5 21 4 20 6 26 6 19 8 24 2
25 12
25 2 24 2 23 5 26 4 26 4 26 2
25 2
26 2 26 2 25 2 25 4 24 4 24 4 22 4 21 6 26 6 24 a 27 4 27 6
19 * 2 19 i 3 21 7 22 6 22 1 3 22 4 19 4
20 3 22 2 20 2
ND 31 6 19 5 18 3 22 6 25 6 26 5 22 4 21 4
19 2 19 2 19 5 21 4 21 3 23 5 21 6 21 4 22 4 12 6 32 3 12 2 16 4 19 1 2 22 7 24 6 22 6 22 5 22 6
20 2 19 3 21 4 20 3
23 8 21 3 18 5 22 4 24 5 22 4
ND ND 20 4 19 2 21 5 27 5 23 9 22 5 24 4
aEach value represents mean i S.D. for a minimum of 3 animals in the first 100 days and all animals thereafter. ND - no data available. ^Statistically significantly different from control mean by Dunnett's test, p<0.05.
200
21 4 20 1 19 3 19 1 18 2 19 2 19 2 19 1 19 2 19 1 18 0 19 1 17 i 21 2 18 + 1 19 2 17 3 19 1 19 L* 19 2 20 1 18 3 19 1 21 2 19 2* 19 1 19 1 17 2
19 * 2 19 2 18 2 18 \ 19 2 18 2 18 1 20 4 19 5 23 6 21 2 19 2 18 2 18 1 20 2 22 3
19 3 20 3 18 4 21 4 20 1 23 * 6 18 2 22 6 21 3 20 3 21 5 21 2 21 8 19 3 22 3 23 10 22 4 22 4 24 2
SL 081997
TABLE 5
MEAN DAILY WATER CONSUMPTION IN GRAMS/RAT/DAY OF MALE AND FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 730(F) OR 731(M) DAYS*
Days on Teat
_sl_ '
Hil _22_
p03e Levels (pptn).
J00_
_0_
100 ^00
0-1 1-2 2-3 3'<4 5-6 6-7 7-a 8-9 9-10 10-11 11-12 22-13 13-14 14-15 17-18 13-19 19-20 20-21 21-22 23-24 27-28 30-31 34-35 37-38 41-42 44-45 48-49 51-52
55-56 58-59 62-63 65-66 69-70 72-73 76-77 79-90 83-84 86-87 90-91 93-94 97-98 104-105 107-108 139-140 142-143 174-175 177-178 209-210 212-213 237-238 240-241 265-266 268-269 293-294 296-297 331-332 335-336 356-357 359-360 385-336 387-388 412-413 415-416 440-441 443-444 468-469 471-472 499-500 503-504 538-539 541-S42 566-567 569-570 594-595 597-598 622-623 625-626 650-651 653-654 685-686 688-689 716-717 720-721
37*1 38:1 39*2 39:2 41:3 41-4 40*4 39:5 42:4 43:4 43:4 4012 42:4 41:4 38:4 39:5 38 + 5 38:5 36:6 38:6 37:3 40*2 39:2 38*3 38:2 39:2 38:4 37:2 36*3 38:2 39*3 46*13 40*3 36*15 42:5 51*16 41:2 39*3 42:3
ND 39:4 42:6 42:7 43:9 427 45:7 46:8 64*6 4i:5 48*8 49:6 50*5 49:7 48:7 45:8 48:8 48t7 49*12 49*11 49+7 48+7 37+11 519 554 54:9 49:12 47+13 61:12 66117 66:10 61113 67114 68:14 75:12 66:16 64:13 72110 69+15 64+13 73:19 73116 71:18 70:20
39:1 40:2 40:3 41:3 42:3 42:3 40 + 3 40+3 4313 41:4 41 + 2 42*4 42+4 42:5 40+2 38+4 42+3 33:9 44:4 43-4 39 + 7 42+5 33:8 42:4 42:8 41+4 44:9 42:3 39+3 44+3* 44*5 41 + 5 43:3 40:8 479 44*4 44 + 5 45+8 47:8 47:5 50+9* 43:8 44-6 47+3 46+6 46+5 47:4 46:6 44 + 5 37:6 47t7 53+6 51+7 50:4 47:5 52:9 517 51+11 43:11 50+5 50+6 56:8* 5417 58+7 55:11 53:11 53112 63:13 6H20 67+1463114 60110 61+16 71+14 71+27 69:14 76+9 7919 76:20 76:20 73:21
67119 79119
40+5 43i5 41:5 44 + 5 -3:4 *6 + 4 45 + 2 +7*4 45:3 47:3 46*3 44+3 45:4 46+5 46:3* 42:4 4^:3 43+3 49111* 43:4 43:4 *4:6 45:4 44:5 ai:j 40:2 42:5 46-4* 38:8 45:4* 42-3 40:4 45:4 48*13 47:6 46:6 51 + 7 46:4 46:6 46:2 46:4 42:6 44:7 46-6 45:5 49+11 44 + 12 49:6 43:5 47:6 47 + 7 56:6* 53+6 53:6 46+12
52:6 51:12 51:6 51 + 7 5814 51:15 50+10* 53:7 6219 61+10 61+12* 56:12 73+15* 68:14* 64*12 62+14 67:21 67+18 68:15 59:17 65:16 68+22 ND 65:14 71:9 70:16 59:29 61:19
36:4 38:4
40:8 33:3 -2:-. 38:6 40:5 }b:9 40:4
43:*1:4 -*-*=4 42:5 42-4 38:6 38+4
31:11 39*4 39+7 36:4 37:5 41 + 7 39:6 35+5 35:5 36:4 38:5 39+5 38:6 40:6 41:6 34+11 41-5 45:3 41:6 40 + 7 43:7 43:6 47:13 43:4 38:7 41+8 40:8 46:7 43:7 46:9 47:7 46-7 44:7 46:5 50-6 54+8 52:8 49:10 46:8 49:6 54* L0 50:8 497 50:7 50:5 46:9* 53:8 51:12 51:8 51+13 56+11 70:13 69:16 69+14 65:L5 65+19 65:12 66+18 70+13 70:12 71:14 76+17 49+25 67+15 70tl2 68 + 20 71:12
31:2 32:3 31 + 2 29'33:2 2>.;4 3i;5 32:15 30:1: 3 7:3 33:4 31:5 32:2 34*3 33+5 28:6 37:8 34:2 36+4 34:2 31 + 1 32+4 34:3 33:4 33:2 37+2 35:2 38:1 34*4 39:3 38:13 45:8 4i:5 42+4 40+7 43:6 43:6 41:5 45+4 43:8 43:4 39+6 39i8 44 + 7 46:7 41:8 49+10 44 + 7 42:9 44:9 46:7 53:8 50+9 49:6 44+12 47 + 9 48:8 50:7 44-6 47:6 47:8 53:9 48:10 53:13 52:15 50-12 48:10 55+9 54 + 12 58+9 58+12 59:14 59+11 58:14 5310 54 + 11 62 + 14 57*11 58:19 57:15 62+17 52+16 56+8
31:1 31:2 30:3 2^:2 ;1:3 3 3:9 30:3 29:3 35:5 33:u: 3U) 30:5 '2:3 30:3 27:5 28:2 28:1* 30:3 29:4 30*3 3 L:5 30:10 30 + U 27:4* 33:7 28:11 36:9 29:6 32:6 27:10 39:11 36:8 39:4
34:3 35:5 43=5 34+8 36:3 34:5 28:9* 37:5 -0:9 41-5 40+4 40:6 42-6 41:6 39+3 41 + 5 59:14* 45 + 7* 46:6 46:7 40:7 41:9 46-6 49:5 43:8 46:6 46*7 55:7 50:15 47=9 49 + 6 46 + 10 48:7 50:7 49 + 7 52-8 55:10 52112 54+10 60:13 53+20 51+9 56+11 54+21 53:22 59:15 55:20 5513 54 + 10
27:fa 3 3'3 } 1:; 29'32:3 3 3:1 .'0:2 31:-
1} j2:2 26: ' 2 34-9 30:4 32 = ) 29:2
28:30:2 34:5 32:3 31:3 36:12 31:3 32-2 291 34-5 34-7 36:4 29:5 38:5 35:5 37+4 37t5 42:14 34=4 38:7 40+9 37:4 35:13 38:11 33+6 37:10 37-6 38:9 40:6 43 = 7 40 + 7* *1 + 9 41-4 44:6 44-7 51+12 54:8 51:10 46:9 47:10 48:9 35:8 48:9 49:9 50:12 52:19 57:11 55:12 50:15 ^9:10*
52 + 12 61:12 63+13 62:19 64:12 6615 60:18 58+16 60+13 55:14 64 + 16 60:16 53:11 66:16 62:17 58:18 57+23
32:3 33=5 31:6
: i, : 39:5 iO + J
J+4 3.:- ;i,=-
3f + : .
:h=_7:C1 34:6 30:3 ",0:4 31:3 i_:5 3 2:3 30:4 >8:2* 31:5 34:4 33 = 1 27:5 J/S7 32:3 32:1* 33:4
35:3 34:4
33=6 3 5+5 42:6 39:10 3^:3 35:4 37 + 5 38:6 40:9 40; 7 * 41:7 39:8* 39*10 39:7 39=10 44:10 49:5 45:7 45:12 43:10 44:9 45:v 49-4 47*9 48:11 45:7 49 + 10 49:6 52 = 13 48+8 48:8 5UU 5510 52:9 55:33 59:11 56=13 56+9 60=18 51+16 58+13 60:i3 54 + 13 63 = 22 57 + 19 62+18 58=16 57 = 13
aach value represent* meant.D. for a minimum of 5 animals In the first 100 days and all animals thereafter.
NT) ^ No data available. Statistically significantly different from control mean by Dunnett's test, p<Q,Q5.
SL 081998
TABLE 6
HEMATOLOGICAL VALUES FOR MALE AND FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 730(F) OR 731(M) DAYS3
Dose Level Days on
PCV Percent
RBC
xlQi-
6
, /mm
3
Ugh 8/100 ml
3 WiJC xlO /mm
(ppm)
Test: 1ST 365 540 701
181
365
540
701
181 365 540 701
181 365 540 701
MALES 0
50+2 50 + 4 47+3 45 + 5 9.2+0.4 7.90.4 7.3+0.7 7.4+0.8 17+1 16 + i 15 + 1 14 + 2 12 + 2 15 + 1 13+3 16+5
50 52 + 2 52 2 49 + 2 44 + 5 8.9+0.3 8.5+0.5 7.9 + 0.7 7.1 + 0.8 18 + 1* lbl 16 + 1 15+ L L73* 16 + 5 14 + 2 164
100 53+4 51+4 486 47+3 9.4+0.6 8.50.8 7.5+0.6 7.6+0.6 18 + 1 171 15 + 2 151 12+1 18 + 5 194* 186
200 54+3 52+3 49+4 47+3 9.50.6 8.50.6 8.0+0.5 7.60.5 18 + 1 17+1 16+0 15 + 1 15 + 3 21 + 9 18+3 172
Days on
FEMALES
Test: 182 365 540 702
182
365
540
702
182 365 540 702
182 365 540 702
0 504 49 + 3 43+4 444 8.5+0.5 7.8+0.2 6.6 + 0.6 6.9+0.6 16 + 1 15 + 1 141 15+1 101 11 + 3 11+4 11 + 5
50 503 48 + 2 454 45+5 8.30.5 7 .8 + 0.6 7.3 + 0.6 6.8 + 1.1 17+1 16 + 1 16+1 15+2 11 + 1 10+2 9+1 113
100 50+3 493 48+1 44+4 8.2 + 0.5 7.8 + 0.4 7.3+0.5 6.9+0.9 161 16 + 1 15+1 14+1 12+2 13+4 12 + 5 9+3
200 49+4 49+2 44+4 46+3 8.0+0.6 7.7+0.4 6.7+0.9 7.1+0.7 16+1 16+1 141 1 51 11+1 10+2 12+4 72
Values are derived from ten animals for days 701 and 702. All others are from 5 animals. Mean i S.D.
SL 081999
TABLE 6 (cont'd)
hematological values for kale and female rats maintained on drinking water containing
VINYLIDENE CHLORIDE FOR 730(F) OR 731(M) DAYS3
Dose Level (ppm)
Days on Test:
Neutr ophils
Seg B. J. Seg. B - J . Seg B.J. Seg . B, J.
Lymphocytes
181 365 540 701 181 365 540 701
MALES 0
50 100 200
18 0 ]5 0 16 0 16 0
14 I 22 0 33 0 29 0
18 0 30 0 31 0 20 0
35 0 34 0 40 0 31 0
77 79 7b 58 79 75 64 59 78 62 61 54 78 64 76 64
FEMALES 0
50 100 200
Days on Test:
182 14 0
16 0
16 0
12 0
365 12 0 16 0 19 0 12 0
540 27 0 17 0 19 0 22 0
702 43 (J 34 0 30 0 29 0
182 365 540 702 82 84 65 50 79 80 78 61 79 76 76 63 84 84 72 65
Monocytes 181 365 540 701
454 5 514 5 4465 54 3 4
182 365 540 7 02 324 6 4234 333J 2255
Eosinophils 181 365 540 701
1122 12?l 212i i32i
182 365 540 702 224 1 1221 22 1 1 121 1
Basophils 181 365 540 701
0000 0000 0000 0000
182
-3--6-5- *
540
--
702
--
0 000
0 000
0000
1 000
Values are derived from ten animals for days 701 and 702. All others are from 5 animals.
SL 082000
TABLE 7
SUMMARY OF URINALYSES FOR MALE RATS MAINTAINED ON DRINKING MATER CONTAINING VINYLIDENE CHLORIDE
FOR 731 DAYS
Dose Level PPM
181 DAYS 0
50
100
1.053*0.012 1.04710.014 1.Q5H0.011
200
365 DAYS 0
50 100 200 540 DAYS
0 50
100 200 701 DAYS
0
50 100
200
1.061+0.005
1.04510.004 1,034+0.007 1,037+0.011 L.03610.005
1,03310.012 1.03810.004 1.03210.015 1.03010.010
1.02610.007 1,024+0.007 1.032+0.012 1.031+0-009
pH ranee
Sugar
Protein
Ketones
Biliruom
Ocoulc Slotid
5. 5-7.0 5. 5-7.0 6, 0-6.5
5. 5-t. 5
Neg(5) Nsg<5) Neg(5)
Neg(5)
lto 3 (5) 2+tD 3+(5) 2+to 4 (5)
2+to 3+(5)
Neg (5)
Neg(3)
Small(1) Trace (L) Neg(3) Small(2) Neg(3 J
Negl5) Neg(5) Neg(5)
Negu'>
Small12) Neg(J) Small(1) Neg Neg (5 J
Neg(51
6,0-7.0 6.0-7.0 6.5-7.5 6.Q-- 7,0
Neg (5) Neg(5) Neg(5) Neg(5)
2 to 3 15) 3+ (5) 3+ (5) 3+ (5)
Neg(5) Neg(5) Neg{5) Neg(5)
Neg(5) Neg(5) Neg(5) Neg(5)
Neg(5) Neg ( 5) Neg(5) Neg(5)
6,0-6, 5 6.0
5.0-7.0 6.0-7.0
Neg(5) Neg(5)
Neg(5) Neg(5)
3 3+
3+ 3+
(5) Neg(5) (5) Neg(5)
(5) Neg(5) (5) Neg(5)
Neg(5) Neg(5)
Neg(5) Neg(5!
Neg(5)
+2(1) Neg(4) Neg (5)
Neg(5)
5.5-6.5
5.5-7.0 5,0-7.0
6.0-6, 5
Neg(10) 3
NegCIO) NegCIO)
3+ 3+
Neg(9)
3+
(10) (10) (10)
(9)
Neg(10)
Neg(10) Neg(10)
Neg(9)
Neg(10 Neg(10) Neg(10)
Neg(9)
Neg(10)
Neg(10) Neg (10)
Neg(9)
' ru! -iro ocn
ND
ND
ND
ND ND ND ND
0.1(5) 0.1(5)
0.1(5) 0.1(5)
0.1(7) 1.0(3) 0.1(10) 0.1(7) 1.0(3) 0.1(8) 1.0(1) ND(1)
Each value represents mean 1SD for 5 rats per group on days 131, 365, and 5h0. lucre -r-ro 10 r n ; per group on day 701.
ND no data available
( ) "no. of animals represented by specified range or mean
SL 8200i
TABLE 8
SUMMARY OF URINALYSES FOR FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE
FOR 730 DAYS
Dose Level PPM
182 DAYS 0
50
Specific Gravity
1.Q25+G.0Q9 1.043+0.009
100 1,042+0.021
200
365 DAYS 0
50 100 200
540 DAYS 0
50 100 200
1.044+0.013
1.029+0,010 1.037+0.011 1,0320.004 1.040+0.005
1.037+0.007 1.023+0.019 1,031+0,011 1.042+0.008
702 DAYS 0
50 LOO 200
1.02860.007 1.036+0.011 1.039*+0.008 1.033+0,011
pH ranze
5.5-6.5 5.5-6.5
6-0-7, 5
5.5-6,5
6.0-6. 5 6.0 5, 5-6.5 6.0
6.0-6.5 5.0-6.0 5,0-6.0 5.0-6.0
6.0-7.0 6.0 5. 5-6.5 5.5-6,5
Sugar
Protein
Ketones
Neg(5) Neg(5)
Neg(5)
Neg(5)
2+to 3+(5) l+to 3+ C 5 >
l+to 3+(5)
l+to 3+(5)
Neg(5) Neg(5)
Trace(l) Neg(4) Neg(5)
Neg(5) Neg(5) Neg(5) Neg(5)
2+to 3+(5) Trace:-3+(5) l+to 3+(5) Trace-3+(5)
Neg(5) Neg(5) Neg(5) Neg(5)
Neg(5) Neg(5) Neg(5) Neg(5)
3+ (5) l+t 3+C5) l+to 3+(5) l+co 3+(5)
Neg(5) Neg(5) Neg(5) Neg(5)
Neg(10) Neg(10) Neg(10) Neg(lO)
3+ 3+ 3+ 3+
(10) (10) (10) (10)
NegCIO) Neg(lO) NegCIO) NegCIO)
Bilirubin
Neg(5) Neg(5)
Neg(5)
Neg(5)
Neg(5) Neg(5) Neg(5) Neg(5)
Neg(5) Neg(5) Neg(5) Neg{5)
Neg (10) Neg(10) Neg(10) NegCIO)
Occult 31ood
Neg(5) Trace(L) Neg^4) Neg<5)
Neg(i)
Neg(5) Neg(5) Neg(5) Neg(5)
Neg(5) Neg(5) Neg(5) Neg(5)
NegCIO) Neg(10) Neg(lO) NegCIO)
\'D ND
ND
ND
ND ND ND ND
0.1(5) 0.1(5) 0.1(5) 0.1(4) 1.0(1)
o.i(io) 0.1(10) 0.1(10) 0.1(10)
Each value represents mean +SD for 5 rats per group on days 182, ,365 and 540. There were 10 rats per group on day 702.
ND * no data available
( ) no. of animals represented by speciflad range or mean
*Significantly different from control mean by Dunnett's teat, p <0.05.
SL 082002
TABLE 9
MEAN CLINICAL CHEMISTRY VALUES FOR MALE AND FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 730(F) AND 731(M) DAYS
Dose Level (ppm)
'Jay 181^
0 50 100 ZOO
Day 184b
0 50 100 200
Day 366
q
50 100 200
Day 541
0 50 100 -00
Day 707
0 50 loo 200
Day ? 31
0 30 100 200
BUN raz/100 ml
Males
SGPT mU/ml
A? mU/ml
Glucose mg/100 ml
20 = 1 23 = 2 19 = 1 ^ 4 2 *
68:9 bb = b 63111 b 3 = 10
368=76 412195 352171 4371174
ND ND ND NO
15 = 2
ND 134133
17-2* ND 127+24
loll
ND 135+21
13 = 1* ND 135125
ND ND ND ND
i712 2 i7 23 = 10 13=4
54 = 5 60i8 59 = 6 5b3
127=19 138121 121+23 146=j6
94=5 100 = 7
9318 36l4
17 *4 25 + 13 20=9 35129
5510 54113 46=10 50H4
104=27 96120
110=27 117122
ND ND ND ND
26 = 12 fj3 = 60*
34il7 . 23-8
419 40 = 8 3817
479
85 = 27 92 = 21 87 = 17 9823
ND ND ND ND
31214 318 4H26 27 = 12
45i9 44S 41 = 7 48=6
64=27 52 = 7 68 = 22
42 = 11
712b 77113 7814
66=17
BUN img/100 ml
Females
SGPT mU/ml
AP mU/ml
20=4 20=2 22 = 3 20 = 1
57 = 5 6118 557 52 + 2
280=65 353+35 224=42 385+59*
183 18 = 3 1812 20=4
ND 95H7 ND 82H5 ND 89+16 ND 94 + 26
16 = 2 19=4 17 = 2 19+5
48+4 501 51118 5014
74i29 109+35
99=13 119132
14=2
1613 16=2 17=4
579 53+8 48110 53114
104+18 97126 98 = 19 94136
L7i4 2015 19=7 17+4
35116 40112 37+8 38+8
54+12 62i20 71117 68+15
18=5 2017 22=9 20+7
40 + 13
45l9 52138 46=15
64 = 38 42+17 54+13 51 + 17
Glucose rag/100 ml
ND ND ND ND
ND ND ND ND
101=14 85 = 11 B69 91=9
ND ND ND ND
ND ND ND ND
69=17 74=18 78115 80l29
^Not fasted. ^Fasted - all others after this were also fasted overnight before sampling.
^Statistically significantly different from control mean using Dunnett's test, p<0.05. ND - Mo data available.
SL 082003
TABLE 10
HEAD BODY WEIGHTS3, ORGAN WEIGHTS, AND ORGAN/BODY WEIGHT RATIOS FOR MALE AND FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 711(M) OR 730(F) DAYS
Dose Level (ppm)
MALES 0
50 100 200
Number of Rats
19 5
a
9
S t arvedOrgan Weights (g and g/100 g Body Weight)
Body
Brain
Heart
Liver
Weight
g g/100 g
s g/100 g
g g/100 g
g
Kidneys g g/100 R
517+65 489+108 516+121 525+85
2.00+0.07 2.070.04 2.000.09 1.98+0.06
0.39+0.05 0.45+0.13 0.41+0.09 0.39+0.06
1.95+0.19 1.86+0.19 1.97+0.19 1.97+0.23
0.38+0.07 0.40+0.14 0.4010.11 0.38+0.06
19.35+4.36 17.66+2.52 16.962.06 17.53+1.72
3.780.91 3.86+1.36 3.39+0.58 3.39+0.49
6.00+2.02 5.79+0.89 6.53+2.L9 5.44+1.J3
1.20+0.56 1 .25 + 0.u2 1.39+0.75 l .07 + 0.M
Testes g g/100 g
3.77+0.70 3.90+0.99 3.80+0.91 4.170.66
0.73+0.14 0.86+0.39 0.74+0.14 0.80+0.09
FEMALES 0
50 100 200
23 386+80
1.85+0.05 0.5010.11 1.43+0.17 0.38+0.07 13.64+3.28 3.58 0.7 2 3.09+0.51 0.83+0.20
18 377+74
1.88+0.08 0.51+0.10 1.40i0.17 G.38+0.08 12.40+2.37 3.32+0.53 3.01+0.42 0.82+0.20
17 405+104 1.810.06 0.47+0.09 1.48+0.15 0.38+0.09 13.51+3.41 3.37+0.43 3.01+0.33 0.78+0.18
15 417+94
1.860.09 0.46+0.09 1.41+0.10 0.35+0.06 14.03+3.09 3.40+0.55 2.90+0.24 0.72+0.13
SL 082004
Sach value represents mean + SD for the number of animals indicated.
TABLE 11
GROSS OBSERVATIONS OF NONTUMOROUS CHANGES IN MALE RATS MAINTAINED FOR 24 MONTHS ON WATER CONTAINING VINYLIDENE CHLORIDE
Number of rats autopsied during the time period indicated
Control 50 ppm 100 ppm 200 ppm
LIVER Enlarged and/or congested
Control 50 ppm 100 ppm 200 ppm
Decreased in size
Control 50 ppm 100 ppm 200 ppm
Small white foci
Control 50 ppm 100 ppm 200 ppm
Red subcapsular foci
Control 50 ppm 100 ppm 200 ppm
Roughened due to chronic passive congestion
Control 50 ppm 100 ppm 200 ppm
Eluid-filled cysts
Control 50 ppm 100 ppm 200 ppm
Accentuation of lobular pattern
Control 50 ppm 100 ppm 200 ppm
Mottled
Control 50 ppm 100 ppm 200 ppm
Strangulation o portion of liver
Control 50 ppm 100 ppm 200 ppm
Paleish discoloration
Control 50 ppm 100 ppm 200 ppm
Congenital anomaly
Control 50 ppm 100 ppm 200 ppm
1-6 Months
1 0 l
:
7-12 Months
3 2 2 3
13-18 Months
15 12 15 10
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 5 48 8 48 9 47
0 0 1 10 1 12 0113 05 0012 03 0152 08
0 02 1 0 3 0011 0 2 00 l0 0 1 0003 14
0 0 0 13 7 20 0015 28 0 0 0 1 2 33 000 5 2 7
0 0 0 7 3 10 000 3 0 3 0 0 0 1 0 la 0002 13
0003 03 0 000 0 0 0 000 0 0 001001
000000 000000 0000 11 000011
001 6 0 7 0005 0 5 000606 0003 14
001 1 0 2 000000 0001 0 1 002 103
001102 000 0 00 000101 0 00000
0 0 2 13 0 15 0 1 2 8 0 11 0 0 1 9 0 10 012 508
000000 000 00 0 0 000 0 0 1 0000 1
aSignificantly different from control data when analyzed using Fisher's Exact Probability Test,, p<0.05.
SL 082005
TABLE 11 (cont'd)
GROSS OBSERVATIONS OF NONTUMOROUS CHANGES IN MALE RATS MAINTAINED FOR 24 MONTHS ON WATER CONTAINING VINYLIDENE CHLORIDE
Number of rats autopsied during Che time period indicated
Control 50 ppm
loo ppm 200 ppm
RESPIRATORY SYSTEM Thoracic Cavity Fibrinous exudate with fluid
Hemorrhage into thoracic cavity
Hydrothorax
Lung Atelectasis (edematous)
Pneumonia
Golden brown pigment
Consolidation
Focal pulmonary fibrosis
Small red foci
Bronchiectasis
Mineralization
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
1-6 Months
1 o
1 2
7-12 Months
3 2 2 3
13-18 Months
15 12 15 10
19-24 Months
42 29 22 23
Terminal Cumulative
Rill
Results
19 80 5 48 8 48 9 47
0 0 0000 0 0 0000 00 0 l0 l 00 0000
00 0000 Q0 010 1 00 000 0
0 0 0101
0 0 0 13 1 14 0 0 07 07 0 0 2 8 1 11 00 1607
0 0 1 11 1 13
000606 0 0 1506 0 0 1607
0 010L 0 ! 1002 0 0000 0 0000
001607 0 0 010 1 00 140 5 00050
0 0 1 001 0 1 0 00 1 000 10 1 000000
0 0 0 0 00
000000
000000
000
01
0003 03 0 0 0 3 0 >
00010
000000
000000 0 0 100 1 0 0 000 0 0 0 0 0 00
0 0 1001 0 0 00 00 000000 0 0 0000
Not significantly different from control data when analyzed using Fisher' s Exact Probability Test, p<0
SL 082006
TABLE U (cont'd)
GROSS OBSERVATIONS OF NONTUMGROUS CHANGES IN MALE RATS MAINTAINED FOR 24 MONTHS ON WATER CONTAINING VINYLIDENE CHLORIDE
1
OQ
Number ot rats autopsied during Che line period indicated
Control
50 ppm 100 ppm 200 ppm
ii:SPIRAIORY SVST E>1 (tont'i)
Uung Ponc'd) Diffuse darkened.areas through-
out lung
Control 30 ppm 100 opm 200 ppn
5mall pale^ubpleural :oci
Control j 0 p pm 100 ppm 200 ppm
Congestion
Control 5Q opm 100 ppm 200 ppm
'CRTNARY SYSTEM
Urinary Bladder Urinary bladder - petccnial
hemorrhage
Control 50 ppm 100 ppm 200 ppm
Urinary bladder -thickenedwall
Control 50 ppm
100 nt>m 200 ppm
Urinary bladder -distensionwith urethral obstruction
Control 50 ppm 100 ppm 200 ppm
Urinary calculi
Control 50 ppm 100 ppm 200 ppm
Kidney Chronic renal disease-minimal
Control 50 ppm 100 ppm 200 ppm
Chronic renal disease-moderate
Control 50 ppm 100 ppm 200 ppm
Chronic renal disease -severe
Control 50 ppm
100 ppm 200 ppm
Enlarged and congested
Control 50 ppm 100 ppm
200 ppm
1-6 Months
1 0 1 :
0 0 0 0
') 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 1
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
7-12 Months
3 2 2 3
0
0
0
0
0 0
0 0
0 0
0 0
Months 15 12 15 10
L
1
3
0
0 0
0 0
0 0
0 1
19-24 Months
42 29 ^2 23
Terminal Cumulative
Kill
Results
19 SO 5 -8 3 +8 9 a7
10 O' 11
10 30 10 1b 303 10
2
20 101 000 10
04 02 00 01 05 01 00
02
04
17 00 0 01 01 00 o
IS 8 9
14
I6
9 8
23
0 20 1 20 0 20 03 03 00 0
Significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.Q5.
SL 082007
TABLE 11 (cont'd)
GROSS OBSERVATIONS OF NONTUMOROUS CHANGES IN MALE RATS MAINTAINED FOR 24 MONTHS ON WATER CONTAINING VI1JYLIDENE CHLORIDE
Number of rats autopsied during the time period indicated
Control 50 ppm 100 ppm 200 ppm
KIDNEY (cont'd) Dilated renal pelvis
Control 50 ppm 100 ppm 200 ppm
Mineralization within renal pelvis Control 50 ppm 100 ppm 200 ppm
Hydronephrosis
Control 50 ppm 100 ppm 200 ppm
Granular debris in renal pelvis
Control 50 ppm 100 ppm 200 ppm
Renal cysts - not directly identified with chronic renal disease
Control 50 ppm 100 ppm 200 ppm
Renal failure cause of death or poor condition
Control 50 ppm 100 ppm 200 ppm
Infarct - focal
Control 50 ppm 100 ppm 200 ppm
Hematocyst
Control 50 ppm 100 ppm 200 ppm
White foci
Control
50 ppm 100 ppm 200 ppm
Decreased in size
Control 50 ppm 100 ppm 200 ppm
Inflammation
Control
50 ppm 100 ppm 200 ppm
1-6 Months
l 0 1 2
7-12 Months
3 2 2 3
13-18 Months
15 12 15 10
19-24 Months
42 29 22 23
Terminal Cumulative Kill Results
19 80 5 48 8 48 9 47
00110 I 0 0 1 0r2 0002 24 003 104
01 0102 000112 000022 002 103
0 0 1 1 02 0 0 0000 01 0001 00 1 001
0 0 1 0 01 00 00 00 0 0 00 00 00 0000
000202 0 0 L 5 0 6a 0 0 2 114 000000
0 0 5 12 0 17 0 0 3 12 0 15 0 0 3 8 0 11 00 2 608
000000 000101 000000 0 0 0000
000011 0 0 00 00 00 00 00 00 0 00 0
00 0 1 0 1 000000 000000 000101
000000 000000 0 01001 0 00000
0 00000 00 0000 000101 000000
^Significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05,
SL 082008
TABLE 11 (cont'd)
GROSS OBSERVATIONS OF NONTUMOROUS CHANGES IN MALE RATS MAINTAINED FOR 24 MONTHS ON WATER CONTAINING VINYLIDENE CHLORIDE
Number of rats autopsied during the time period
ind icated.
Control 50 ?pm 100 ppm 200 ppm
cardiovascular system
Heart Heft atrial thrombosis
Control 50 ppm 100 ppm 200 ppm
Dilated ventricles Pale foci in muscle Degeneration Pericarditis
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm LOO ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Mineralization Rupture
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Aorta Dilated and inelastic
Control 50 ppm 100 ppm 200 ppm
Mesenteric Vessels Periarteritis
Control 50 ppm 100 ppm 200 ppm
Nodular areas in mesenteric vessels - vascular in nature
Control 50 ppm 100 ppm 200 ppm
1-6 Months
i 0 i 2
7-12 Months
3 2 2 3
13-18 Months
15 12 15 10
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 3 18 8 48 9 47
0 00 8 08
000 L 01 002 709
001 7 08
0007 13 0003 03 0013 15 001 1 13
00 00 1 1 000000 0 000 00 o000 1 1
0 0 2 9 1 12 001 2 03 0004 15 0006 0 6
000000
0000 1 L
0 0 0 'J 0 0
000
00
001001 0 00 00 0 000 10 1 00020 2
0000 0 0 00000 0 0 01 1 0 2 0000 00
0 0 4 9 0 13 003 4 07 002204 0025 I9
0 0 3 8 l 13 001607 004 509 0 0 1 9 3 13
000000 000000 00000 0 0001 01
Not significantly different from control data when analyzed using Fisher' 9 Exact 'Probability Test, p<0.
SL 082009
TABLE 11 (cont'd)
GROSS OBSERVATIONS OF NONTUMOROUS CHANGES IN MALE RATS MAINTAINED FOR 24 MONTHS ON WATER CONTAINING VINYLIDENE CHLORIDE
Number of rats autopsied during the time period indicated
Control 50 ppm 100 ppm 200 ppm
ABDOMINAL CAVITY Intra-abdorainal fluid or blood
Adipose Tissue Depleted (moderate to severe)
Obese
GASTROINTESTINAL SYSTEM Tongue Edema on distal aspect of the
tongue
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Ulcer on tongue
Stomach Gastric ulcers or erosions -
focal
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Gastric hemorrhage - focal
Control 50 ppm 100 ppm 200 ppm
Gastric mineralization
Control 50 ppm 100 ppm 200 ppm
Gastric distension with air
Control 50 ppm 100 ppm 200 ppm
Gastrointestinal tract devoid of feed and feces
Control 50 ppm 100 ppm 200 ppm
1-6 Months
i 0 1 2
7-12 Months
3 2 2 3
13-18 Months
15 12 15 10
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 5 48 8 48 9 47
00 L 203 0 0 0 1 o- 1 002 305 00 0000
00 1 607 0 0 4 9 0 13 4 1 0 4 6 2 134 0 0 3 7 0 10a
00 08 08 01 13 0 5 0 1 2003 02 0103
000000 000101 0 0 0 0 00 0 0 0000
0 0 0 000 00 0101 0 0 0000 00 0000
0 1 0 11 3 15 002507 002608 000909
003 003 0001 01 001102 001 3 04
0 0 6 7 0 13 004 509 005 3 08 00140 5
00000 0 000000 00 200 2 000i01
0 0 2 002 000202 0 0 1 6 0 7a 0 0 0 7 0 7a
Significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082010
TABLE 11 (cont'd)
GROSS OBSERVATIONS OF NONTUMOROUS CHANGES IN MALE RATS MAINTAINED FOR 24 MONTHS ON WATER CONTAINING VINYLIDENE CHLORIDE
Number of rats autopsied during the time period indicated
Control 50 ppm 100 ppm 200 ppm
GASTROINTESTINAL SYSTEM (cont'd) Stomach (cont'd) Thickened gastric mucosa
Gastric cyst
Large Intestine Parasites
Volvulus of large intestine
Cecum Hemorrhagic and edematous
REPRODUCTIVE SYSTEM Testicles - enlarged
Testicles - atrophy
White foci in seminiferous tubules
White foci on testicle
Testicle hyperemic
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
1-6 Months
1 0 1 -
7-12 Months
3 2 2 3
13-18 Months
15 12 15 10
19-24 Months
42 29 ) 1
23
Terminal Cumulative
Kill
Results
19 80 5 48 8 48 9 47
0 0 4 h 0 10 0042 08 002 3 0 5 00-002
0000 00 000 0 00 0000 00 001001
0 0 00 00 000000 000 1 1 2 000011
00010 1 000000 0 00 0 0 0 000000
002
08
001 506
000
05
000- 04
0002 2 4 000 i0 1 0000 0 0 0 000 0 0
0 0 6 15 2 23 0 1 1 12 1 15 1 0 4 9 0 14 0 0 5 12 2 19
000 314 000 1 12 000 0 1 1 000 12 3
000 1 01 000000 000000 000 10 1
00 1 0 01 000000 000000 0 00 00 0
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082011
TABLE U (cont'd)
GROSS OBSERVATIONS OF NONTUMOROUS CHANGES IN MALE RATS MAINTAINED FOR 24 MONTHS ON WATER CONTAINING VINYLIDENE CHLORIDE
Number of rats autopsied during the time period indicated
Control 50 ppm 100 ppm 200 ppm
REPRODUCTIVE SYSTEM (cont'd) Accessory sex gland - atrophy
Accessory sex gland - enlarged and inflamed
Epididymal fat pad edema or hyperemia
Epididynaal fat pad atrophy
Prostate gland - enlarged
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Contro1 50 ppm 100 ppm 200 ppm
Abscessed preputial gland
Control 50 ppm 100 ppm 200 ppm
NERVOUS SYSTEM
Pituitary gland - hemorrhagic foci Control 50 ppm 100 ppm 200 ppm
Dark focal area at center of brain Control 50 ppm 100 ppm 200 ppm
Paralysis of posterior portion of animal
Control 50 ppm 100 ppm 200 ppm
ENDOCRINE GLANDS Thyroid and Parathyroid Parathyroid hyparplasia
Control 50 ppm 100 ppm 200 ppm
Thyroid * decreased in size
Control 50 ppm 100 ppm 200 ppm
1-6 Months
1 0 1 i
7-12 Months
3 2 1
3
13-18 Months
15 12 15 10
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 5 48 3 48 9 47
0 0 3 9 0 12 000 7 0 7 1 01 4 0b 001405
0 00 101 0 00 000 0 00 0 00 002 l03
00 0 000 000000 0 0 0 0 00 002 002
000 2 24 000 10 1 001 00 I 000 1 0 1
0 0 0 00 0 000000 000000 00 2 002
000202 000101 0000i 1 000000
00002 2 0 0000 0 000 l 0 1 000 2 0 2
000000 000 1 01 000 000 000 00 0
000000 000 000 000000 1 0000 1
0
0
0
3 11
14
0 0 0 2 10 12
000 2 6 8
0 0 0 2 9 11
00020 2
000000 000000 000000
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082012
TABLE 11 (eont'd)
GROSS OBSERVATIONS OF NONTUMOROUS CHANGES IN MALE RATS MAINTAINED FOR 24 MONTHS ON WATER CONTAINING vinylidene CHLORIDE
Num: , : rats autopsied during the time period indicated
Control 50 ppm 100 ppm 200 ppm
1-6 Months
1 0 1 7
ENDOCRINE GLANDS (cont'd) Adrenal Gland Mottled appearance
Control 50 ppm 100 ppm 200 ppm
Decreased in. size
Control 50 ppm 100 ppm 200 ppm
INTEGUMENTARY SYSTEM Keratinized epidermal inclusion
cyst
Mammary gland hyperplasia
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
MUSCULOSKELETAL SYSTEM Skeletal demineralization
Control 50 ppm 100 ppm 200 ppm
LYMPHQRET1CULAR SYSTEM
Lymph node - swollen, congested* enlarged and/or edematous local
Control 50 ppm 100 ppm 200 ppm
Spleen
Splenomegaly - extramedullary hematopoiesis
Control 50 ppm 100 ppm 200 ppm
Splenic atrophy (decreased in size)
Control 50 ppm 100 ppm 200 ppm
EYE Atrophy - unilateral
Control 50 ppm 100 ppm 200 ppm
Corneal opacity - unilateral
Control 50 ppm 100 ppm
200 ppm
0 'J 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
7-12 Months
3 2 2 3
13-18 Months
15 12 '5 10
19-24 Months
42 29 12 23
Terminal Cumulative
Kill
Results
19 80 5 48 8 48 9 47
0 00 08 009
001
000
000
00 1
0 12
00 1
001
000
0 01
0 00
ooo 0 01
0 0 0 0
0 0 0 0
0 0 0 1
0 0
0 0
0l10
003 0
0110
003 0
0 0 10 1
0 03 0
0 04 1 0 13 1
12 00 00
10
3 4 1
2
00i 000 000 ooo
1 0
0
0
0 0 0 0
0 ooo 0 ooo 0 ooo
000 1
00
2
0 12
00
1
ooo
5 0 2 0
16 5 9 9
i 0 o 1
3 1 1 1
1 0
0 l
2 3 2 3
11
j
5 5
7 4
i
3
1 0 0 0
0 0 0 1
7 3 3 0
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082013
TABLE 11 (cont'd)
GROSS OBSERVATIONS OF NONTUMOROUS CHANGES IN MALE RATS MAINTAINED FOR 24 MONTHS ON WATER CONTAINING VINYLIDENE CHLORIDE
Number of rats autopsied during the time period indicated EYE (cont'd) Corneal opacity - bilateral
Cataracts
GENERAL Postmortem change
Cannibalism
Emaciation
Malocclusion
Anemia
Ulceration of hard palate
Focal alopecia
Control 50 ppm 100 ppm 200 ppm
1-6 Months
i 0 1 2
7-12 Months
3 2
2 3
13-18 Months
15 12 15 10
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 5 48 8 48 9 47
Control
0
0
2
3 10 15
50 ppm
0
0
0
6
3
9
100 ppm
0
0
1
6
4 11
200 ppm
0
0
1
2
5
8
Control
0
0
0
0
4
4
50 ppm
0
0
0
0
0
0
100 ppm
0
0
0
0
0
0
200 ppm
0
0
0
0
1
1
Control
0
3
5
5
0 13
50 ppm
0
1
3
3
0
7
100 ppm
1
1
5
2
0
9
200 ppm
0
2
4
3
0
9
Control
1
1
1
i
04
50 ppm 0 1 1 i 0 3
100 ppm
0
0
0
0
0
0
200 ppm
0
0
1
1
0
2
Control
0
1
2
4
1
8
50 pom 0 0 1 6 0 7
100 ppm
1
0
1
6
0
8
200 ppm
0
0
0
5
0
5
Control
0
0
0
0
0
0
50 ppm 0 0 0 1 0 1
100 ppm
1
0
1
0
1
3
200 ppm
0
0
0
1
0
i
Control
0
0
0
0
0
0
50 ppm 0 0 2 0 0 2
100 ppm
0
0
0
1
0
1
200 ppm
0
1
0
1
0
2
Control
0
0
0
0
0
0
50 ppm 0 0 0 0 0 0
100 ppm
0
0
1
0
0
1
200 ppm
0
0
0
0
0
0
Control
0
0
0
0
0
0
50 ppm
0
0
1
0
0
1
100 ppm
0
0
0
0
0
0
200 ppm
0
0
0
0
0
0
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082014
TABLE 12
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time par ltd indicated
1-6 Months
Control
50 ppm 100 ppm 2Q0 ppm
1
Q 1 l
LIVER
Centrilobular hepatocellular degeneration Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Centrilobuiar hepatocellular atrophy
Control 50 opm 100 ppm 200 ppm
0 0 0 0
Hepatocellular atrophy without fatty change
Control 50 ppm 100 ppm 200 ppm
1 0 1 1
Periportal hepatocellular hypertrophy
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Hepatocellular atrophy with fatty change
Control 50 ppm LOO ppm 200 ppm
0 0 0 0
Centnlobular hepatocellular fatty de generation
Control 50 ppm 100 ppm 200 ppm
1 0 0 0
Hepatocellular fatty change, location not specified
Control 50 ppm LOO ppm 200 ppm
0 0 0 0
Centrilobular hepatocellular atrophy with fatty change
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Total number of rats with hepatocellular fatty change or fatty degeneration
Control 50 ppm 100 ppm 200 ppm
1 0 0 0
Focus of hepatocellular alteration eosinophilic ground glass appearance
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focus of hepatocellular alteration clear cell appearance
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
7-12 Months
3 2 2 3
L 0 0 0
0 0 0 0
1 1 0 1
0 0 1 0
0 0 0 0
1 1 0 l
0 0 0 0
0 0 0 0
1 1 0 1
0 0 0 0
0 0 0 0
13-18 Months
15 12 15 10
1 0 2 1
3 0 L. 3
9 8 9 2
0 0 1 2
0 0 0 1
1 0 1 3
0 1 1 1
0 0 0 0
1 1 2 5
0 1 0 0
0 1 1 0
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 5 18 8 48 9 47
3 05 2 0' 1 h 08
517
4 3 10 1 0 l3
1 03
3 06
22 9 42
20 3 32 9 6 25 5 6 15a
000 000 0 0 2a 103
000
000
0 0 0a
:03
4 3 10
2 03
6 8
0 1
7 13
aa
123 00 1 034 01 2
101 101 202 10l
6 5 14
305
8 3 13 n 2 19a
7 7 14 315 224 34 7
6 28 4 27 012 325
aSignificantly different from control data when ana lyzed using Fisher''s Exact Probability Test, p<0.05.
SL 082015
TABLE 12 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
1-6 Months
Control 50 ppm 100 ppm 200 ppm
1 0 1 2
7-12 Months
3 n
z
3
LIVER (cont'd) Focus of hepatocellular alteration -
basophilic appearance
Area of hepatocellular alteration eosinophilic ground glass appearance
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Area of hepatocellular alteration clear cell appearance
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal hepatic necrosis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Generalized hepatic necrosis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal vascular sinusoidal dilatation
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal vascular dilatation with hepatocellular alteration
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal hepatocellular alteration characterized by cystic degeneration
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal extramedullary hematopoiesis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal biliary hyperplasia
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal periportal fibrosis or sclerosis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
1 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
1 0 0 0
13-18 Months
15 12 15 10
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 5 48 a 48 9 47
0 0 11
0
0
01
0
0000
0101
01 12 0000 0 000 0000
0101 0 101 0000 0000
1113 1102 2 2 15 1 102
0203 0 10 1 2 305 0202
08 08 04 04 100 1 0000
0000 0000 0 10 1 0000
15 28 0i01 0 i01 0 0 00
1 001 0000 0 00 0 0101
1203 0202 0303 0 00 0
1 7 3 12 03 0 3 1214 162 9
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082016
TABLE 12 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
N'umber of rats autopsied during the time period indicated
1-6 Months
Control 50 ppm 100 ppm Z00 ppm
1 0 1 2
Multiloculated biliary cyst formation
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Foci of mononuclear inflammatory cells Located within the hepatic lobule or oortal area
Control 50 ppm 100 ppm 200 ppm
1 0 1 2
Biliary hyperplasia, focal
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Dilatation of bile ducts
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Biliary inflammation
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Hyalinization of hepatic vessels
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Increase in number cells lining the
of reticuloendothelial sinusoids
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
RESPIRATORY SYSTEM
Trachea Focal subepithelial mononuclear inflam-
matory cell infiltrate
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Lungs
Chronic pulmonary lesions characterised by edema, Interstitial thickening and fibrosis, inflammatory cell infiltrate and exudation of cells into the alveoli with or without atelectasis (associated with advanced cardiac or renal disease)
Control 50 ppm 100 ppm 200 ppm
Focal interstitial pneumonitis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
0 0 0 0
7-12 Months
5 2 z 3
0 0 0 0
3 1 2 2
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
13-18 Months
15 12 15 10
1 0 0 0
14 11 14 10
1 0 0 0
0 0 0 1
0 0 0 0
0 0 0 0
0 0 0 0
8
2 2
3 0 3 1
0 0 0 0
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 5 48 8 48 9 47
50 2 02 i 12 0 22
40 17 75 26 5 43 20 7 44 21 9 44
2 03 202 3 03 0 00
0 00 000 000 001
000 000 011 000
0 00 1 01 000 000
000 000 000 101
17
9
34 -a
4 06
215
518
16 0 19 4 04 7 0 10 7 08
011 000 000 000
^Significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082017
TABLE 12 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsled during the time period indicated
1-6 Months
Control 50 ppm 100 ppm 200 ppm
i 0 1 2
7-12 Months
3 2 2 3
13-18 Months
15 12 15 10
19-24 Terminal Cumulative
Months_______ Kill
Results
42 19 80 29 5 48 22 8 48 23 9 47
RESPIRATORY SYSTEM (cont'd)
Lungs (cont'd) Peribronchial mononuclear inflammatory
cell infiltrate
Control 50 ppm 100 ppm 200 ppm
1 0 1 2
Focal alveolar histiocytosis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal thickening of the inter-alveolar septae
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Acute suppurative pneumonia
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal metaplastic bone formation within the lung
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Pleurltls with acute inflammation
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Portion of lung collapsed, atelectatic and inflamed
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Mineralization of interalveolar septae
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Hematogenous pigment in lung
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal hyperplasia of epithelial alveolar lining cells
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
3
14
32
19
69
1 10 25
5 41
2 13 12
8 36
3 9 16 9 39
0 8 18 7 33 0 0 9 2 11?a 0 1 2 4 ,A 1 04 16
00235 0 0 0 00 0 1001 0 0 000
0 0000 10001 0 0101 0 0000
0 1102 0 0000 0 0000 0 0000
0 0000 1 0001 00000 00000
00101 0 0000 0 0000 0 0000
0 3 003 003 03 0 3 1 04 0 01 01
00202 00000 0 100 1 00000
0 010 1 0 000 0 0 1001 00000
Significantly different from control data when analysed using Fisher's Exact Probability Test, p<0.05.
SL 082018
TABLE 12 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN MALE RATS MAINTAINED ON WATEC CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
1-6 Months
Control 50 ppm 100 ppm 200 ppm
1
0
1 ">
7-12 Months
3 i
2 5
13-18 Months
15 12 L5 10
19-24 Months
42 29 22 23
Terminal Cumulativt
Kill
Results
19 80 5 48 3 48 9 47
URINARY SYSTEM Kidney Minimal degree of chronic nephropathy
Control 50 ppm 100 ppm 200 ppm
0 0 0 1
Moderate degree of chronic nephrooathy
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Severe degree of chronic nephropathy
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
End stage nephropathy
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal mineral deposit within the kidney
Control 50 ppm 100 ppm 200 ppm
0 0 0 1
Focus of mononuclear cell infiltrate
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Multifocal mononuclear cell infiltrate
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Hydronephrosis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Acute suppurative pyelonephritis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Renal cortical cysts
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal chronic inflammation, infarction and vascular fibrosis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
l 4 b 2 14
1 3 509
2 3 4 1 10
220
7
0 3 9 9 21 0 5 6 3 14 0i539 0 2 7 5 14
0 3 20 8 31 I 1 9 2 13 0 7 6 4 17 0 4 10 2 16
1 6 7 0 14 0 3 9 0 12 0 4 7 0 11 02 608
0 9 5 1 15 I 3 9 0 13 04 3 18 0 3 206
1 2 b 2 11 03 205 01203 1 1 i14
1 7 30 15 53
0 5 27 5 37
1 12 19
7 39
0 9 21 7 37
01102 00000 00000 0 0 L 0 .1
00000 00000 00000 00 101
00 101
000
30
000
1
000
0
000
0
0000
000 1
0000
Not significantly different from control data when analyzed using Fisher's Exact Probability Test , pc.
/
>
SL 082019 .
TABLE 12 (coni'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during Che time period indicated
1-6 Months
Control 50 ppm 100 ppm 200 ppm
1
0 1 2
URINARY SYSTEM (cont'd) Kidney (cont'd) Focal cortical abscess
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Thrombosis with focal infarction
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Chronic interstitial nephritis
Control 50 ppm 100 ppm 200 ppm
Renal pelvis distended with blood clot (nontumorous formation)
Control 50 ppm 100 ppm 200 ppm
Focal renal cortical tubular hyperplasia
Control 50 ppm 100 ppm 200 ppm
Urinary Bladder Urocystitis
Control 50 ppm 100 ppm 200 ppm
Diffuse hyperplasia of urinary bladder mucosa
Control 50 ppm 100 ppm 200 ppm
Submucosal edema and hemorrhage of urinary bladder
Control 50 ppm 100 ppm 200 ppm
Focal hyperplasia of the pelvic trans itional epithelium
Control 50 ppm 100 ppm 200 ppm
GASTROINTESTINAL TRACT
Tongue
Subepithelial focus of mononuclear in flammatory cell infiltrate without a foreign body present
Control 50 ppm 100 ppm 200 ppm
7-12 Months
3 2 2 3
0 0 0 0
0 0 0 0
13-18 Months
15 12 15 10
0 0 0 0
1 0 0 0
19-24 Montns
42 29 22 33
Terminal Cumulative
Kill
Results
19 80 0 48 8 48 9 4 7
L 0 ]_ 0 00 0 00 0 0j
001 0 00 0 00 0 00
19 29
22
00
11 14
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082020
TABLE 12 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
dumber of rats autopsied daring the time period Lndicated
1-6 Months
Control 50 ppm 100 ppm 200 ppm
1 0
1 2
GASTROINTESTINAL TRACT (cont'd;
Tongue (cont'd)
Subepithelial focus of mononuclear in flammatory cell infiltrate with a foreign body present
Control 50 ppm 100 ppm 200 ppm
Focal granulomatous inf lamination without a foreign body present
Control 50 ppm 100 ppm 200 ppm
Focal granulomatous inf lamination with a foreign body present
Atrophy of the lingual serous glands
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Vascular fibrinoid degeneration
Control 50 ppm 100 ppm 200 ppm
Mineralization of vessels in the tongue
Control 50 ppm 100 ppm 200 ppm
Hyallnization of vessels in the tongue
Control 50 ppm 100 ppm 200 ppm
Edema of the tongue
Control 50 ppm 100 ppm 200 ppm
Fibrinous inflammatory reaction
Control 50 ppm 100 ppm 200 ppm
Hyperplasia of the squamous lining epi thelium
Keratinization of serous gland duct epithelium
Control 50 ppm 100 ppm 200 ppm
7-12 Months
3 2 2 3
0 0 0 0
0 0 0
0
0 0 0 0
0 0 0
0
u
0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0
0
0
13-13 Months
15 12 15 10
0 0 0 0
0 0 0 0
0 0 0 0
1 0 0
0
1
0 0 0
1
0 0
1
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0
0
0
0
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 48 48
9 47
75 00 00 52
02 00 00 00
65 00 10 55
J1 00 00 12
43 00 10 52
10 00 00 10
01 00 00 00
00 10 00 00
10 00 00 00
11 00 00 00
00 00 00 10
12 0 0 7
2 0 0 0
11 0 1 8
5 0 0 3
8 0 1 7
2 0 0 2
L 0 0 0
0 1
0 0
1 0 0 0
2 0 0 0
0 0 0 1
Not signif1,antly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082021
TABLE 12 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN MALE RATS MAINTAINED ON WATER CONTAINING VINVLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
1-6 Months
Control 50 ppm 100 ppm 200 ppm
1 0 1 2
GASTROINTESTINAL TRACT (cont'd)
Salivary Glands
Focal chronic inf lamination with or without fibrosis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Atrophy
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Thickening of interstitial support tissue in gland
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Edema of salivary gland
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Stomach
Submucosal edema of the nonglandular portion
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal gastric ulceration and hemorrhage
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Hyperplasia and/or hyperkeratosis of the gastric, nonglandular epithelium
Control 50 ppm 100 ppm 200 ppm
1 0 0 0
Mineralization of gastric mucosa
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Intraepithelial necrosis - focal
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Infarction secondary to mesenteric periarteritis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Hyperplasia of submucosal lymphoid tissue
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
7-12 Months
3 2 2 3
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
13-18 Months
15 12 13 10
0 0 0 0
0 1 0 0
0 1 0 0
0 0 0 0
2 l 1 1
1 2 0 0
1 1 2 0
8 3 5 4
1 0 0 0
1 0 0 0
0 0 0 0
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 5 48 8 48 9 47
101 000 000 101
101 001 000 000
000 001 000 101
000 101 000 000
2 15 001 I02 113
102 103 404 415
316 001 103 000
5 0 13 8 0 11 6 0 11 6 0 10
001 000 000 000
001 000 000 000
101 000 000 000
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05
SL 082022
TABLE 12 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
1-6 Months
Control 50 ppm 100 ppm 200 ppm
1 0 i 2
GASTROINTESTINAL TRACT (cont'd)
Stomach (conn'd)
Keratinization of the squamous epitheliutn of the stomach
Control 50 ppm 100 ppm 200 ppm
1 0 0 0
Inflammation of nonglandular epithelium and/or glandular epithelium
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Gastric cyst
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Larae Intestine Intestinal nematodiasis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Edema, ulceration, and inflammation of the cecum due to uremia
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Inflammation of serosa and submucosa of large intestines
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Pancreas
Focal atrophy of pancreatic acinar tissue
Control 50 ppm 100 ppm 200 ppm
0 0 1 0
Focal interstitial pancreatitis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
CARDIOVASCULAR SYSTEM
Heart Minimal degree of focal myocardial de-
generation and fibrosis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
7-12 Months
3 2 2 3
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
1 0 0 0
1 0 0 0
2 2 0 1
13-18 Months
15 12 15 10
0 0 0 0
1 1 0 0
0 0 0 1
1 0 0 1
2 0 0 0
0 0 0 1
2 4 3 4
2 2 2 2
3 2 0 7
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 5 48 8 48 9 47
00i 000 0 00 000
113 001 000 000
000 000 000 001
5 8 14 000 000 14 6
4 06 1 01 202 1 01
000 000 000 001
12 5 20 12 3 19a
3 4 11 9 5 18
13 6 22 11 3 16
248 8 5 15
18 6 29 8 5 17
10 6 16a 11 7 26a
aSignificantly different from control data when analyzed using fisher'1s Exac t Probability Test, P<0.05.
SL 082023
TABLE 12 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
1-6 Months
Control 50 ppm
100 ppm 200 ppm
1 0 1 2
7-12 Months
3 2 2 3
13-18 Months
15 12 15 10
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 5 48 8 48
9 47
CARDIOVASCULAR SYSTEM (cont'd)
Heart (cont'd)
Moderate degree of focal myocardial
Control 0
0
5 10 11 26
degeneration and fibrosis
50 ppm
0
0
5 10
0 15
100 ppm 0 0 3 2 0 5
200 ppm 0 0 2 6 2 10
Severe degree of focal myocardial Control 0 1 5 9 1 16
degeneration and fibrosis
50 ppm
0
0
2
5
0
7
100 ppm 0
0
3
2
0
5
200 ppm 0 0 1 2 0 3
Left atrial thrombosis
Control 0 0 0 8 0 8
50 ppm
0
0
1
1
0
2
100 ppm 0 0 1 6 0 7
200 ppm 0 0 1 7 0 8
Endocardial fibroelastosis
Control 0 0 0 3 0 3
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 1 0 1
Focal myocardial mineralization
Control 0 l 3 3 0 7
50 ppm
0
0
1
5
0
6
100 ppm 0 0 0 2 1 3
200 ppm 0 0 1 3 0 4
Inflammatory cell infiltrate within myo- Control 0 0 1 1 2 4
cardium
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 0 0 0
Hypertrophy of ventricular myocardium
Control 0
0
0
0
0
0
50 ppm
0
0
0
0
0
0
100 ppm 0 0 1 0 0 1
200 ppm 0 0 0 0 0 0
Focal necrosis of myocardium
Control 0 0 1 0 0 1
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 0 0 0
Focal area of infarction
Control 0 0 0 0 1 1
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 0 0 0
Aorta Aortic mineralization
Control 0 1 5 9 2 17
50 ppm
0
1
4 11
1 17
100 ppm 0 0 6 6 1 13
200 ppm 0 1 2 8 1 12
Hemorrhage in aortic wall with inflam-
Control 0
0
0
0
0
0
mation
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 1 0 1
Significantly different from control data when analyzed using Fisher ' s Exact Probability Test* p<0.05.
SL 082024
TABLE 12 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN MALE BATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsled during the time period indicated
1-6 Months
Control 50 ppm 100 ppm 200 ppm
i 0 1 2
7-12 Months
3 2 2 3
13-18 Months
15 12 15 10
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 5 48 8 48 9 47
CARDIOVASCULAR SYSTEM (cont'd) Mesenteric and Other Vessels Periarteritis and sclerosis
Control 0 0 4 12 2 18
50 ppm
0
0
0
9
0
9
100 ppm 0 0 5 10 0 15
200 ppm 0 0 2 8 2 12
Hyalinization, sclerosis, and/or fibrin- Control 0 0 1 8 4 13
old degeneration suggestive of peri-
50 ppm
0
0
3
2
1
6
arteritis
100 ppm 0 0 3 3 0 6
200 ppm 0 0 0 5 2 7
Mineralization of mesenteric blood
Control 0
0
5
3
1
9
vessels
50 ppm
0
0
0
5
0
5
100 ppm 0 0 2 3 2 7
200 ppm 0 0 0 4 0 4
Mineralization of pulmonary vessels
Control 0
0
0
0
0
0
50 ppm
0
0
1
0
0
1
100 ppm 0 0 1 0 0 1
200 ppm 0 0 0 0 0 0
Hyalinization and/or sclerosis of myo-
Control 0
0
0
0
1
1
cardial blood vessels
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 0 0 0
REPRODUCTIVE SYSTEM Testis Atrophy
Vascular fibrinoid degeneration
Focal areas of abscessation
Sperm granuloma
Mineralization of seminiferous tubules with or without sclerosis
Control 50 ppm 100 ppm 200 ppm
0 0 1 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
0 1 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 1 0 0
8 26 3 14 49 6 16
8 42 1 19 2 16 4 26
5 21 2 13 25 4 17
01 00 00 00
00 01 00 00
7 33 1 16 29
3 24
01 00 00 00
00 01 00 00
2 30 5
0 2 14 0 00 0 1 113
Not significantly different from control d.
an analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082025
TABLE 12 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated REPRODUCTIVE SYSTEM (cont'd) Testis (cont'd) Focal atrophy of seminiferous tubules
Accessory Sex Glands Atrophy
Diffuse chronic inflammation
Suppurative inflammation of accessory sex glands
Abscess of preputial gland
Squamous metaplasia of abscessed preputial gland
Edema of penis (prepuce)
Epididymis Atrophy
Hypoplastic
1-6 Months
Control 50 ppm 100 ppm 200 ppm
1 0 1 2
7-12 Months
3 2 2 3
13-18 Months
15 12 15 10
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 30 5 48 8 48 9 47
Control 0 0 0 0 1 1
50 ppm
0
0
0
0
00
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 0 0 0
Control 0 0 0 0 0 0
50 ppm
0
0
0
1
0
1
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 0 0 0
Control 0 0 0 2 0 2
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 1 0 1
200 ppm 0 0 2 0 0 2
Control 0 0 0 1 0 1
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 1 0 1
200 ppm 0 0 0 0 0 0
Control 0 0 0 1 0 1
50 ppm
0
0
0
1
0
1
100 ppm 0 0 0 0 1 1
200 ppm 0 0 0 1 0 1
Control 0 0 0 1 0 1
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 0 0 0
Control 0 0 0 1 0 1
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 0 0 0
Control 0 0 4 17 7 28
50 ppm
0
0
2 11
1 14
100 ppm 1 0 3 7 2 13
200 ppm 0 0 3 8 2 13
Control 0 0 0 0 1 1
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 0 0 0
Not significantly different from control data when analyzed using Fisher1 a Exact Probability Test, p<0.<
SL 082026
TABLE 12 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
REPRODUCTIVE SYSTEM (cont'd) Epididymis (cont'd) Focal chronic inflammatory cell infil-
trate
Suppurative inflammation
Prostate Chronic interstitial prostatitis
Suppurative prostatitis
NERVOUS SYSTEM AND ENDOCRINE SYSTEM Brain Focal malacia of the brain
Areas of malacia associated with brain tumor formation
Focal myelin vacuolization in cerebrum and cerebellum
Spinal Cord Vacuolization of myelin
Peripheral Nerve Vacuolization of myelin
1-6 Months
Control 50 ppm 100 ppm 200 ppm
1 0 1 2
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
7-12 Months
3 2 2 3
0 0 0 0
0 0 0 0
0 0 0 0
0 0 1 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
13-18 Months
15 12 15 10
0 0 0 0
0 0 0 0
0 0 0 0
1 1 1 3
0 0 0 0
1 0 0 0
1 0 0 0
5 0 0 2
6 0 0 3
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 5 48 8 48 9 47
1 12 0 00 0 00 0 00
101 0 00 0 00 0 00
213 202 000 000
405 203 114 2 05
101 101 000 202
001 000 000 000
001 000 000 000
24 19 48 000 101
14 8 24
23 17 46 0 00 000
13 8 24
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05
i
SL 082027
TABLE 12 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
1-6 Months
Control 50 ppm LOO pom 100 ppm
1 0 1 2
NERVOUS SYSTEM AND ENDOCRINE SYSTEM
Peripheral Nerve (conn'd)
Focal area of cholesterol cleft formationi Control 50 oom 100 ppm 200 ppm
0 0 ') 0
Pituitary Gland Sinusoidal dilatation
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Hyperplastic focus
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Microcyst in pituitary
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Multiloculated pituitary cyst
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
\drenal Glands Hematocyst formation
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Vascular dilatation of adrenal
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Area of coagulation necrosis
Control 50 ppm 100 ppm 200 ppm
0 0 0 j
Focal lipomatosis of the adrenal cortex
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Mineralization of adrenal cortex
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
7-12 1Months
3 2 2 i
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 1 0 0
0 0 0 0
0 0 0 0
1 0 0 0
0 0 0 0
13-18 Months
15 12 L5 10
0 0 0 0
0 0 0 1
0 0 0 0
0 0 0 1
0 0 0 0
3 0 1 3
0 0 0 0
0 0 0 0
7 4 2 4
0 1 1 0
19-24 Months
42 29 22 23
Terminal Cumulative
Rill
Results
19 80 5 48 8 48 9 47
0 1 1 000 000 000
3 l4 202 202 102
145 4 15 0 00 000
202 i01 000 001
000 10x 000 000
427 506 3 15 003
0 1x 0 00 000 000
101 000 000 000
19 10 37 10 4 18
34 9 9 3 16
000 00 1 00 1 00 0
data when analyzed using Fisher's Exact Probability Test , p<0.05.
SL 082028
TABLE 12 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the rime period indicated
1-6 Months
Control 50 ppm 100 ppm 200 ppm
1 0
1 2
NERVOUS SYSTEM AND ENDOCRINE SYSTEM (cont'd)
Adrenal Glands (cont'd)
Focal hyperplasia of the adrenal cortex
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Atrophy of adrenal cortex
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Hyperplastic focus in adrenal medulla
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Thyroid Gland Focal hyperplasia of C cells
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Parathyroid Gland Hyperplasia
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
SUBCUTANEOUS TISSUE, MAMMARY GLAND AND INTEGUMENT
Diffuse non-specific chronic dermatitis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Epidermal inclusion cyst
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
MUSCULO-SKELETAL SYSTEM Atrophy of skeletal muscle
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
EYE Chronic focal keratitis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
7-12 Months
3 2 2 3
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
1 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
13-18 Months
15 12 15 10
0 0 0 0
0 0 0 0
1 2 2 1
0 2 0 2
7 5 5 4
0 1 0 0
1 0 0 0
5 0 0 2
2 1 0 0
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 5 48 8 48 9 47
000 0 00 101 000
101 0 00 000 000
326 3 16 125 405
235 428 134 305
20 1 29 16 2 23 10 i 16
8 1 13
000 001 000 000
203 101 112 022
18 9 32 000 000
15 7 24
013 023 011 156
Not significantly
.rent from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082029
TABLE 12 (coni'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN MALE RATS MAINTAINED ON HATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated EYE (cont'd) Cataract
Suppurative ophthalmitis
ADIPOSE TISSUE Atrophy of mediastinal fat
LYMPHORETICULAR SYSTEM Mediastinal Lymphoid Tissue Hematogenous pigment deposits
Atrophied
Hyperplasia
Edematous
Hyperemic
Sinusoidal dilatation
Sclerosis
1-6 Months
Control
50 ppm l00 ppm 200 ppm
1
0
1 2
7-12 Months
3 2 C 3
13-18 Months
15 1C 15 10
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80
5 48 8 18 9 47
Control
50 ppm 100 ppm 200 ppm
0 0
0
0
Control 50 ppm 100 ppm COO ppm
0
0
(J
0
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
000
0u0
0 00 0 00
1 00 0 00
0 L0 000
0 b 15
1 5 12 0 10 11 L 3 11
33 00 00 00
01
00
0 ]_ 00
1 22 0 18 1 22a 1 16
Control 50 ppm 100 ppn 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 opra
u 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 100 ppm
0 '> -i 3
Control 50 ppm 100 ppm 200 ppm
0 o ') J
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
0 0 ) )
0 1 1 0
0 I o J
0 J ') )
0 0 i j
)
0 0 0
0 0 0 0
19 02
4 12
6 8 35 5
04 00 03 11
01 0
0
00
01 i0 I0
*0
3 00 o0 00
10 00 00 00
0 10 02 05 05
L9 0 Ua 09 07
0
01
03 02
01 00 00 00
01 00 00 00
0 00 00
00
01 00 00 00
Significantly different from control data when analyzed using Fisher's exact Probability Test, p<0,05.
SL 082030
TABLE 12 (cont'd)
NONTUMOROUS histopathologic lesions in MALE RATS MAINTAINED ON WATER containing vinylidene CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
1-6 Months
Control 50 ppm 100 ppm 200 ppm
1 0 l 2
LYMPHORETICULAR SYSTEM (cant'd) Mesenteric Lymph Nodes Sinusoidal vascular dilatation
Hyperplasia
Atrophy
Edema
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Increased hemosiderin pigment in mesen' teric lymph node
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Lymphangiectasia of mesenteric lymph nodes or ocher lymph nodes
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Other Lymph Nodes Hyperplasia
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Spleen Atrophy of spleen with or without hemo -
siderin pigment
Increased hemosiderin deposits within the spleen
Hyperplasia
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
0 0 1 0
0 0 0 0
0 0 0 0
7-12 Months
3 ? 2 3
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
2 1 1 0
0 0 0 0
1 0 0 0
13-18 Months
15 12 15 10
0 0 0 0
0 0 0 1
0 0 0 2
1 0 0 2
1 0 0 0
0 0 0 0
0 0 0 0
7 4 1 5
1 0 0 0
0 1 0 1
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 5 48 8 48 9 47
2 02 0 00 0 00 101
426 000 1 12 1 13
000 000 000 1 03
2 14 101 011 103
203 000 000 101
011 10 1 000 000
10 1 000 011 0 00
14 0 23 6 0 11 5 08
10 0 15
102 000 000 000
2 03 001 101 0 01
Significantly different from control data when analyzed using Fisher1 s Exact Probability Test, p<0.05.
SL 082031
TABLE 12 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
LYMPHORETICULAR SYSTEM (cont'd) Spleen (cont'd) Increased extramedullary hematopoiesis
in. spleen
Thymus Atrophy
1-6 Months
Control 50 ppm 100 ppm 200 ppm
1 0 1 2
Control 50 ppm 100 ppm 200 ppm
1 0 0 1
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
7-12 Months
3 2 2 3
1 0 1 1
0 0 0 0
13-18 Months
15 12 15 10
3 3 2 0
0 0 0 0
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 5 48 8 48 9 47
8 4 ' 17 9 0 12 2 16 619
101 000 000 000
Not significantly different from control data when analyzed using Fisher's :Exact Probability Test , p<0.05.
SL 082032
TABLE 13
TUMOR OR TUMOR-LIKE LESIONS GROSSLY RECOGNIZED IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
Control ppm
100 ppm 200 ppm
LIVER Nodular proliferation in the
liver - primary site
Nodular proliferation in liver metastatic foci
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm L00 ppm 400 ppm
Diffuse tumor infiltrate and enlarged - associated with lymphoid proliferation
KIDNEY Tumor - primary site
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Tumor - metastatic lesion
Control 50 ppm 100 ppm 200 ppm
RESPIRATORY SYSTEM
Lung - focal nodule - metastatic tumor
Control 50 ppm 100 ppm 200 ppm
GASTROINTESTINAL TRACT
Proliferative lesion involving the tongue
Control 50 ppm 100 ppra 200 ppra
Salivary gland - enlarged
Control 50 ppm 100 ppm 200 ppm
Gastric tumor
Control 50 ppm 100 ppm 200 ppm
Small intestinal tumor or dlverticulum
Control 50 ppm 100 ppm 200 ppra
Large intestinal tumor
Control 50 ppra 100 ppra 200 ppm
1-6 Months
1 0 1 2
7-12 Months
3 2 2
3
13-18 Months
15 12 15 10
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 30 5 43 8 48 9 47
0002 3 5 000 10 1 00100 1 000000
000000 001001 000000 0000 00
0 000 0 0 001102 0001 01 0 0 00 00
0 100 1 2 0001 0 1 000000 0000 00
0000 0 0 0010 0 I 0 000 0 0 000G 0 0
00001 1 001 102 000 10 1 000 10 1
00101 2 001 102 001 1 02 010001
000 2 0 2 000 1 0 1 000000 000000
000101 000 1 0 i 00000 0 000000
0002 1 3 000101 00002 2 000000
0001 0 1 000000 00001 1 00 000 0
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082033
TABLE 13
TUMOR OR TUMOR-LIKE LESIONS GROSSLY RECOGNIZED IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
Control 50 ppm 100 ppm 200 ppm
GASTROINTESTINAL TRACT (cont'd) Pancreatic nodule
Control 50 ppm 100 ppm 200 ppm
Pancreas - tumor involving pancreas and other abdominal viscera
Control 50 ppm 100 ppm 200 ppm
REPRODUCTIVE SYSTEM Testicular tumor - unilateral
Control 50 ppm 100 ppm 200 ppm
ENDOCRINE SYSTEM Brain Tumor
Control 50 ppm 100 ppm 200 ppm
Tumor of cranial nerve
Control 50 ppm 100 ppm 200 ppm
Pituitary gland - increased in size
Control 50 ppm 100 ppm 200 ppm
Thyroid - increased in size
Control 50 ppm 100 ppm 200 ppm
ADRENAL GLAND Enlarged - unilateral
Control 50 ppm 100 ppm 200 ppm
Enlarged - bilateral
Control 50 ppm 100 ppm 200 ppm
MUSCULOSKELETAL SYSTEM Tumor within pelvic canal
Control 50 ppm 100 ppm 200 ppm
1-6 Months
1 0 1 2
7-12 Months
3 2 2 3
13-18 Months
15 12 15 L0
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 5 48 8 48 9 47
0
0
0 14
5,
19
0 0 1 8 1 10
0 0 0 4 0 4a
0014 2 7
00 0000 00 0000 000101 00 0000
0 0 00 0 0 000000 00 00 00 000101
001001 000000 000000 000000
100001 00 0000 000000 000000
000606 001203
000314 00 12 14
00 0i 3 4
0
0
0~
3
0
3
000112
000101
0012 14 0002 13 000213 001 102
00140 5 00010 1 002002 0 0 010 1
00100i 00 0000 000000 000000
Significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082034
TABLE 13 (cont'd)
TUMOR OR TUMOR-LIKE LESIONS GROSSLY RECOGNIZE? IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLOR E FOR 24 MONTHS
Number of rats autopsied during the time period indicated
Control 50 ppm 100 ppm 200 ppm
MUSCULOSKELETAL SYSTEM (conc'd) Tumor of the skull
Control 50 ppm 100 ppm 200 ppm
LYMPHORETICULAR SYSTEM Lymph node - tumor consisting of
lymphoid tissue
Local invasion of tumor with regional lymph node involved
Thymus enlarged
Splenomegaly - tumor related
Control 50 ppm 100 ppm 2QQ ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
INTEGUMENTARY SYSTEM
Subcutaneous tumor - mammary and midcervical region
Control 50 ppm 100 ppm 200 ppm
Subcutaneous tumor - eye* ear and head region
Control 50 ppm 100 ppm 200 ppm
Subcutaneous tumor - body/limb
Control 50 ppm 100 ppm 200 ppm
Subcutaneous tumor - preputial gland region
Control 50 ppm 100 ppm 200 ppm
EYE Ocular enlargement
Control 50 ppm 100 ppm 200 ppm
MISCELLANEOUS
Intra-abdominal tumor - origin uncertain
Control 50 ppm 100 ppm 200 ppm
1-6 Months
1 0 1 2
7-12 Months
3 2 2 3
13-18 Months
15 12 15 10
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 5 48 8 48 9 47
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 l/la
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 1 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 l/la 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 1 0
0 0 0 0
0 1 0 0
0 1 0 0
0 1 0 0
0 1 0 0
l/la 0 0 0
1 0 0 0
0 1 0 0
0 0 0 0
0 0 1 0
0 0 0 0
0 0 0 0
1 3 0 0
3 3 1 1
0 1 0 0
2 1 2 0
3/3a 4/4a 1/La l/la
2 1 0 2
1 1 0 0
0 0 1 0
1 0 0 0
2 0 0 0
0 0, 0 0
0 1 0 0
23 04 22 00
03 04 01 01
11 02 11 00
13 02 02 00
2/2a 2/2a 4/4a 4/2a
1 0 0 0
1 0 0 0
0 0 0 0
6/6a 6/6a 6/63 6/4a
4 1 0 2
2 2 0 0
0 0 1 0
01 00 01 00
02 00 01 00
Not significantly different from control data when ana lyzed using Fisher's Exact Probability Test, p<0.05 ^Number of tumors/number of animals with tumors*
J )
SL 082035
TABLE 13 (conn'd)
TUMOR OR TUMOR-LIKE LESIONS GROSSLY RECOGNIZED IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsted during the time period indicated
Control 50 ppm 100 ppm ZOO ppm
MISCELLANEOUS (cant'd)
Tumor implants on intra-abdominal viscera
Control 50 ppm 100 ppm ZOO ppm
Nodule in. omentum
Control 50 ppm 100 ppm 200 ppm
1-6 Months
1 0 1 2
7-12 Months
3 2 Z 3
13-18 Months
15 12 15 10
19-24 Months
kl 29 22 23
Terminal Cumulative
Kill
Results
19 80 5 48 8 48 9 47
0 0 0 00 0
0
0
0
0
0.
0
00 0000
00 0 10 1
0 0 0000 00 010 1 0 0 00 0 0 00 0000
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082036
TABLE 14
HISTOPATHOLOGIC DIAGNOSIS AND NUMBER OF TUMORS IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
Control 50 ppm 100 ppm 200 ppm
LIVER Neoplastic nodule (hepato-
cellular hyperplastic nodule
Hepatocellular carcinoma without metastasis
Hepatocellular carcinoma with metastasis
URINARY SYSTEM Kidney Nephroblastoma
Renal tubular adenoma
GASTROINTESTINAL TRACT Tongue Keracoacanthoma
Squamous cell papilloma of the tongue
Squamous cell carcinoma without metastasia
Hard Palate Keratoacanthoma
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
1-6 Months
1 0 1 2
7-12 Months
3 2 2 3
13-18 Months
15 12 15 10
19-24 Months
42 29 22 23
Terminal Kill
19 5 8 9
Cumulative Results
80 48 48 47
0000 I 1 0000 0 0 0000 0 0 0000 0 0
0000 2 2 00000 0 00100 1 0 000 0 0
0 00 0 0 0 000000 0 000 00 0001 01
01000 I 0 00 0 0 0 000000 0000 0 0
0000 1 1 0001 1 2 00000 0 000000
00100 1 000I0 1 0000 0 0 0 100 0 1
0000 00 000 1 0 1 000 0 0 0 0000 0 0
00001 1 00 1 0 0 1 00 10 0 1 00000 0
0 00 0 0 0 000000 000000 000101
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082037
TABLE 14 (cont'd)
HISTOPATHOLOGIC DIAGNOSIS AND NUMBER OF TUMORS IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
Control 50 ppm 100 ppm 200 ppm
GASTROINTESTINAL TRACT (cont'd)
Salivary Gland
Medullary carcinoma without metastasis
Control 50 ppm 100 ppm 200 ppm
Stomach
Leiomyosarcoma without metastasis
Control 50 ppm 100 ppm 200 ppm
Leiomyosarcoma with metastasls to the liver
Control 50 ppm 100 ppm 200 ppm
Small Intestine
Mucinous cyscadenocarcinoma without .metastasis
Control 50 ppm 100 ppm 200 ppm
Mucinous cystadenocarcinoma with metastasis to the large intestine
Control 50 ppm 100 ppm 200 ppm
1-6 Months
I 0 1 2
7-12 Months
3 2 2 2
13-18 Months
15 12 15 10
19-24 Months
42 29 22 23
Terminal Kill
19 5 8 9
Cumulative Results
80 48 43 47
00 1 001 000000 00 0 00 0 000000
00 0 101 00 0 000 0 0 0 000 000101
00 0 000 000 10 1 000000 000000
000 2 0 2 0 0 0 00 0 000 01 1 000000
000000 00000 0 00001 1 000000
Leiomyosarcoma without
Control
0
0
0
0
1
1
metastasis
50 ppm 0 0 0 0 0 0
100 ppm
0
0
0
0
0
0
200 ppm
0
0
0
0
0
0
Leiomyosarcoma with metas-
Control
0
0
0
0
0
c
tasis to the liver
50 ppm 0 0 0 1 0 1
100 ppm
0
0
0
0
0
0
200 ppm
0
0
0
0
0
0
Pancreas Acinar adenoma
Control
0
0
0
7
2
9
50 ppm 0 0 1 4 2 7
100 ppm
0
0
1
2
0
3
200 ppm
0
0
1
1
4
6
Islet cell adenoma
Control
0
0
0
6
4 10
50 ppm
0
0
0
1
1
2
100 ppm
0
0
0
2
1
3
200 ppm
0
0
0
5
3
8
Not significantly different from control data when analyzed using Fisher1 3 Exact Probability Tes p<0,05.
SL 082038
TABLE 14 (cont'd)
HISTOPATHOLOGIC DIAGNOSIS AND NUMBER OF TUMORS IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
Control 50 ppm 100 ppm 200 ppm
1-6 Months
1 0 1 2
7-12 Months
3 2 2 3
13-18 Months
15 12 15 10
19-24 Months
42 29 22 23
Terminal Kill
19 5 8 9
Cumulative Results
80 48 48 47
RESPIRATORY SYSTEM Lung Pulmonary adenoma
Control
0
0
0
0
0
0
50 ppm 0 0 0 0 0 0
100 ppm
0
0
0
0
1
1
200 ppm
0
0
0
0
0
0
CARDIOVASCULAR SYSTEM
Heart
Chemodectoma (aortic body
Control
0
0
0
0
0
0
tumor)
50 ppm 0 0 0 0 0 0
100 ppm
0
0
0
0
0
0
200 ppm
0
0
0
1
0
1
REPRODUCTIVE SYSTEM
Testicle
Interstitial cell adenoma
Control
0
0
0
0
2
2
50 ppm 0 0 0 1 0 1
100 ppm
0
0
0
0
0
0
200 ppm
0
0
0
0
0
0
Epididymis
Focal mesothelioma of the
Control
0
0
0
0
1
1
tunica vaginalis
50 ppm 0 0 0 0 0 0
100 ppm
0
0
0
0
0
0
200 ppm
0
0
0
0
0
0
NERVOUS SYSTEM AND ENDOCRINE GLANDS
Brain Astrocytoma
Control
0
0
1
0
0
1
50 ppm 0 0 0 0 0 0
100 ppm
0
0
0
0
0
0
200 ppm
0
0
0
0
0
0
Oligodendroglioma
Control
0
0
0
0
0
0
50 ppm 0 0 0 1 0 1
100 ppm
0
0
0
0
0
0
200 ppm
0
0
0
0
0
0
Spinal Cord Glioblastoma
Control
0
0
0
0
0
0
50 ppm 0 0 0 0 0 0
100 ppm
0
0
0
0
0
0
200 ppm
1
0
0
0
0
1
Not significantly different from control data when analyzed using Fisher's Exact Probability Test p<0,05.
SL 082039
TABLE 14 (cont'd)
HISTOPATHOLOGIC DIAGNOSIS AND NUMBER OF TUMORS IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
Control 50 ppm 100 ppm 200 ppm
1-6 Months
i 0 1 2
NERVOUS SYSTEM AND ENDOCRINE GLANDS (corn'd)
Pituitary Gland
Adenoma
Contro I 50 ppm 100 ppm 200 ppm
0 0 0 0
Carcinoma without brain invabion
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Adrenal Gland
Adrenal cortical carcinoma without metastasis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Pheochromocytoma, unilateral
Control 50 ppm LOO ppm 200 ppm
0 0 0 0
Pheochromocytoma, bilateral
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Malignant pheochromocytoma without metastasis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Total number of rats with a pheochromocytoma
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Thyroid Gland C-cell adenoma
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
C-cell carcinoma without metastasis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
C-cell carcinoma with mecastasis to the lungs
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
7-12 Months
3 2 2 3
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
13-18 Months
15 12 15 10
0 1 0 1
0 0 0 0
0 0 0 0
1 1 1 0
0 0 2 1
0 0 0 0
1 1 3 l
1 0 0 0
0 0 0 0
0 0 0 0
19-24 Months
42 29 22 23
Terminal Kill
19 5 8 9
Cumulative Results
80 48 48 47
6 4 10 416 336 427
i01 000 000 011
101 000 000 000
9 7 17 8 1 11 04 5 7 4 11
54 9 101 406 203
02 2 101 000 000
14 13 28 10 2 13
4 4 11 9 4 14
3 i5 303 202 325
011 000 000 000
011 000 011 000
Not significantly different f rom control data when analyzed using Fisher1 s Exact Probability Test p<0,05.
SL 082040
TABLE 14 (cont'd)
HISTOPATHOLOGIC DIAGNOSIS AND NUMBER OF TUMORS IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during Che time period indicated
Control j0 ppm I 00 ppm COO ppm
1-6 Months
1 0 i 2
7-12 Months
3 2 2 i
13-18 Months
15 12 15 10
19-24 Months
42 29 22 23
Terminal Kill
19 5 8 9
Cumulative Results
30 48 48 47
LYMPHORETtCULAR SYSTEM
Generalized lymphosarcoma with widespread tissue mvolvement
Control 50 cpm 100 ppm 500 ppm
Hemangioma of the mesenteric lymph node
Control 50 ppm 100 ppm 200 ppm
Spleen Hemangioma
Control 50 ppm 100 ppm 200 ppm
Thymus
Thymoma without other lymphoid tissue Involvement
Control 50 ppm 100 ppm 200 ppm
INTEGUMENTARY SYSTEM
Ml
Retrobulbar undifferentiated sarcoma without metastasis
Control 50 ppm 100 ppm 200 ppm
Preputial Gland
Squamous cell carcinoma without metastasis
Control 50 ppm 100 ppm 200 ppm
Integument Subcutaneous fibroma
Control 50 ppm 100 ppra 200 ppm
Subcutaneous fibrous histiocytoma
Control 50 ppm 100 ppm 200 ppm
Subcutaneous adenofibroma/ fibroadenoma of the mammary region
Control 50 ppm 100 pptn 200 ppm
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
00 l01 01 2 0 3 00 1 0 l 00000
000 00 000 00 000 1 1 000 00
001 0 1 000 00 000 00 000 00
000 11 00000 000 1 1 000 0 0
0 0 0 0
0 0 0 0
0 0 l/la 0
0 0 0 0
0 0 0 0
0 1 0 0
0 0 0 0
0 0 0 0
0 l/la
0 0
0 0 0 0
101 001 000 00 0
000 000 101 000
3/3a 2/2a
0 0
0 0 0 l/la
l/la
1Aa l/la
0
L/1a 2/2a l71a 3/ 2a
0 0 0 0
l/la 0
3/3a 0
4/4a 4/4a 2/2a 3/2a
0 l/la
0 l/la
2/2a i/La 4/4
0
Not significantly different from control data when analyzed using Fisher's Exact Probability Testj p<0.05.
dumber of tumors/number of rats with tumors.
SL 082041
TABLE 14 (cont'd)
HISTOPATHOLOGIC DIAGNOSIS AND NUMBER OF TUMORS IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
Control 50 ppm 100 ppm 200 ppm
integumentary system
Preputial Gland
Subcutaneous fibroma of the mammary region
Control 50 ppm 100 ppm 200 ppm
Subcutaneous adenocarcinoma of the mammary gland without metastasis
Control 50 ppm 100 ppm 200 ppm
Subcutaneous carcinosarcoma of the mammary gland without metastasis
Control 50 ppm 100 ppm 200 ppm
Ear Canal Gland
Sebaceous squamous cell carcinoma of the external ear canal gland (Zymbal gland) without metastasis
Control 50 ppm 100 ppm 200 ppm
Sebaceous squamous cell carcinoma of the external ear canal gland (Zymbal gland) with metastasis to Che lungs
Control 50 ppm 100 pptn 200 ppm
Musculoskeletal System
Osteogenic sarcoma of rear limb without metastasis
Control 50 ppm 100 ppm 200 ppm
MALIGNANT SCHWANNOMA
Pelvic canal location without metastasis but locally destructive
Control 50 ppm 100 ppm 200 ppm
Cranial cavity location without metastasis
Control 50 ppm 100 ppm 200 ppm
Mediastinal location without metastasis
Control 50 ppm 100 ppm 200 ppm
1-6 Months
1 0 1 2
7-12 Months
3 2 2 3
13-18 Months
15 12 15 10
19-24 Months
42 29 22 23
Terminal Kill
19 5 8 9
Cumulative Results
80 48 48 47
0 0 0 0
0 0 0 0
0 0 0 l/la
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
00 00 00 00
00 00 01 00
10 00 00 00
00 00 00 00
0 00 0
0 000
0 000
0
l/la
0
l/la
0 000
0
L/la
0
l/la
0 0 00
0000
0 000 0 0 00
0000 0 0 0 l/l3
1001 0000 0000 0 101
0 101 001 1 0000 0000
001 1 0 00 0 0000 0000
0000 0000 0001 0000
0001 0000 00 0 0 0000
001 1 00 0 0 0 00 0 0000
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
dumber of tumors/number of rats with tumors.
SL 082042
TABLE 14 (cont'd)
HISTOPATHOLOGIC DIAGNOSIS AND NUMBER OF TUMORS IN MALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
Control 5C ppm 100 ppm 200 ppm
1-6 Months
1 0 1 2
MALIGNANT SCHWANNOMA (cont'd)
Subcutaneous salivary gland Control location without metastasis 50 DDm 100 ppm 200 ppm
0 0 0 0
Undifferentiated Sarcoma, ProbaDle Neural Origin
Pelvic canal and rear limb region without metastasis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Pelvic canal location without Control
metastasis
50 ppm
100 ppm
200 ppm
0 0 0 0
Intra-abdominal Tumor
Fibrosarcoma with widespread metastasis, origin undetermined
Centre 1 50 ppm 100 ppm 200 ppm
0 0 0 0
7-12 Months
3 2 2 3
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
13-18 Months
15 12 15 10
0 0 0 0
0 0 0 0
1 0 0 0
0 0 0 0
19-24 Months
42 29 22 25
Terminal Kill
19 5 8 9
Cumulative Results
80 48 48 47
1 01 000 0 00 0 00
101 000 000 0 00
001 000 000 000
000 000 101 000
Not significantly different from cuntrol data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082043
TABLE 15
NUMBER OF MALE RATS FOR WHICH THE SPECIFIED TISSUE WAS EXAMINED MICROSCOPICALLY (Rats Maintained for 24 Months on Water Containing Vinylidene Chloride)
Number of rats autopsied during the time period indicated Liver Kidney
Heart Pancreas Spleen Lung Skeletal Muscle Mediastinal Lymphoid Tissue Mediastinal Fat Salivary Glands Aorta Esophagus
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
1-6 Months
1 0 1 2
1 0 1 2
1 0 1 2
i 0 1 2
i 0 1 2
1 0 1 2
1 0 1 2
1 0 0 1
1 0 1 1
0 0 0 1
1 0 0 1
1 0 1 1
0 0 1 2
7-12 Months
3 2 2 3
3 2 2 3
3 2 2 3
3 2 2 3
3 2 2 3
3 2 2 2
3 2 2 3
2 0 0 2
3 2 2 3
3 1 1 3
3 0 0 2
3 2 2 2
2 2 2 3
13-18 Months
15 12 15 10
15 12 15 10
15 12 15 10
15 12
6 10
14 11
4 10
15 11
4 10
15 12 15 10
14 0 1 7
13 10 13
8
11 10 14
9
12 3 0 7
12 12 14 10
10 12 13 10
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 5 48 8 48 9 47
42 19 80 29 5 48 22 8 48 23 9 47
42 19 80 29 5 48 22 8 48 23 9 47
42 19 80 28 5 47 14 8 31 23 9 47
41 19 78 27 5 45 14 S 29 23 9 47
42 19 80 27 5 45 11 8 26 23 8 45
42 19 80 29 5 48 22 8 48 23 9 47
41 17 75 i01 203
22 9 41
39 19 75 29 5 46 21 8 45 22 9 43
38 16 68 27 5 43 19 8 42 20 9 42
37 10 63 104 101
18 4 32
37 19 72 26 3 43 21 7 45 20 9 42
39 18 69 29 5 48 21 8 45 23 8 46
SL 082044
TABLE 15 (cont'd)
NUMBER OF MALE RATS FOR WHICH THE SPECIFIED TISSUE WAS EXAMINED MICROSCOPICALLY (Rats Maintained for 24 Months on Water Containing Vinylidene Chloride)
Number of rats autopsied during the time period indicated Trachea Parathyroid Thyroid Stomach Small Intestine
Large Intestine Mesenteric Lymph Node Mesenteric Vessels Urinary Bladder Epididymis Testes Accessory Sex Glands
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 pom 100 ppm 200 pom
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 doth 200 ppm
Control 50 ppm 100 ppm 200 ppm
Contro L 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
1-6 Months
1 0 1 2
1 0 1 2
0 0 0 1
0 0 0 2
1
0]_ ;
1 0 0 2
1 0 0 2
I 0 0 L
0 0 0 1
1 0 1 ->
1 0 1 2
1 0 1 2
1 0 0 1
7-12 Months
3 2 2 3
3 2 2 3
3 1 0 i
3 1 2 2
3 1 2 3
3 0 0 -
3 0 0 2
3 0 0 1
2 0 0 1
3 0 1 3
2 2 0 1
2 2 0 2
3 1 0 3
13-18 Months
15 12 15 10
14 12 13
9
11 11
5 9
13 12
5 10
15 11 13 10
14 2 0
10
14 1 0 9
12 3 2 9
9 3 4 5
14 5 4
10
13 3 5
10
15 4 5
10
14 5 5
10
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 5 48 8 48 9 47
41 19 78 27 5 46 22 8 46 23 9 46
38 15 67 25 5 42 14 7 26 21 9 41
42 18 76 27 5 45 15 7 29 22 9 45
42 19 80 25 5 42 21 8 45 23 9 47
41 18 77 9 0 11
11 2 13 23 8 45
41 18 77 506 426
23 9 45
35 18 69 12 1 16 10 2 14 21 9 41
24 11 46 13 0 16
8 0 12 14 6 27
41 18 77 16 0 21 11 18 23 y 47
40 19 75 13 1 19 11 2 19 23 9 45
42 19 79 14 1 21 11 2 19 23 9 46
40 17 75 16 0 22
9 1 15 23 9 46
SL 082045
TABLE 15 (cont'd)
NUMBER OF MALE RATS FOR WHICH THE SPECIFIED TISSUE WAS EXAMINED MICROSCOPICALLY (Rats Maintained for 24 Months on Water Containing Vinylidene Chloride)
Number of rats autopsled during the time period indicated Prosta.ce
Peripheral Nerve
Spinal Cord
Pituitary Gland
Adrenal Gland
Cerebellum
Cerebral Cortex
Eyes
Tongue
Skin
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
1-6 Months
i 0 1 2
1 0 0 2
i 0 0 1
0 0 0 2
0 0 0 2
i 0 1 1
0 0 1 2
1 0 1 2
1 0 0 0
1 0 0 0
0 0 0 0
7-12 Months
3 2 "i 3
3 2 1 3
3 0 0 1
3 0 0 2
1 1 1 1
3 2 2 1
3 2 2 2
3 2 2 2
1 0 0 1
1 0 0 2
1 0 0 0
13-18 Months
15 12 15 10
14 5 5
10
14 0 0 9
12 0 0 9
11 6 3 7
15 11
5 10
15 11
4 9
15 12
4 10
3 4 1 2
6 1 1 6
2 2 0 1
19-24 Months
42 29 22 23
Terminal Cumulative
Kill
Results
19 80 5 48 8 48 9 47
40 17 75 13 0. 20 U 1 18 23 9 47
37 18 73 000 000
21 9 4 .
40 19 74 000 1 01
23 9 45
32 18 62 25 4 36
9 8 21 19 9 36
42 19 80 29 5 47 11 8 27 23 9 44
42 19 79 28 5 46
9 8 24 23 9 45
41 19 79 28 5 47
9 7 22 23 9 46
1 12 18 1 5 10 15 7 2 9 14
38 17 63 405 102
22 9 39
18 15 36 103 101 5 8 13
SL 082046
TABLE 16
GROSS OBSERVATIONS OF NONTUMOROUS CHANGES IN FEMALE RATS MAINTAINED FOR 24 MONTHS ON WATER CONTAINING VINYLIDENE CHLORIDE
Number of rats autopsied during the time period indicated
Control 50 ppm 100 ppm 200 ppm
1-6 Months
0 0 0 1J
7-12 Months
1 0 3 0
13-18 Months
15 5 4
13
19-24 Months
41 25 24 20
Terminal Cumulative
Kill
Results
23 30 18 48 17 48 15 48
LIVER Enlarged and/or congested
Decreased in si2e
Contro1
0
0
1
4
0
5
50 ppm 0 0 1 4 0 5
L00 ppm
0
0
1
0
0
1
200 ppm
0
0
0
0
2
2
Control
0
0
1
3
0
4
50 ppm 0 0 0 1 0 1
100 ppm
0
1
0
3
0
4
200 ppm
0
0
2
7
1 10a
Small white foci Red subcapsular foci
Control
0
0
0
3
4
7
50 ppm 0 0 1 5 2 8
100 ppm
0
0
0
2
4
6
200 ppm
0
0
1
4
4
9
Control
0
0
2 12 17 31
50 ppm 0 0 0 5 4 9a
r100 ppm
0
0
0
4
3
200 ppm
0
0
0
4
5
9a
Roughened due to chronic passive Control
0
0
0
1
0
1
congestion
50 ppm 0 0 0 0 0 0
100 ppm
0
0
0
0
0
0
200 ppm
0
0
0
0
0
0
Fluid-filled cysts
Control
0
0
1
6
1
8
50 ppm 0 0 0 1 0 1
100 ppm
0
0
0
1
0
1
200 ppm
0
0
0
i
1
2
Accentuation of lobular pattern
Control
0
0
1
5
0
6
50 ppm 0 0 0 3 0 3
100 ppm
0
0
0
1
0
1
200 ppm
0
0
0
2
24
Mottled liver
Control
t
0
0
0
0
0
50 ppm 0 0 0 1 0 1
100 ppm
0
0
0
3
0
3
200 ppm
0
0
0
0
0
0
Strangulation of portion of liver Control
0
0
0
0
0
0
50 ppm 0 0 0 1 0 1
100 ppm
0
0
0
2
0
2
200 ppm
0
>'
0
i
0
1
Palelsh discoloration
Control
0
0
1
9
1 11
50 ppm
0
0
0
7
1
8
100 ppm
0
0
1
6
0
7
200 ppm
0
0
1
5
3
9
RESPIRATORY SYSTEM Thoracic Cavity Hydrothorax
Control
0
0
0
4
1
5
50 ppm 0 0 0 0 0 0
100 ppm
0
1
0
1
0
2
200 ppm
0
0
0
1
0
1
Significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082047v
TABLE 16 (cont'd)
GROSS OBSERVATIONS OF NONTUMOROUS CHANGES IN FEMALE RATS MAINTAINED FOR 24 MONTHS ON WATER CONTAINING VINYLIDENE CHLORIDE
Number of rats autopsied during the time period indicated
Control 50 ppm 100 ppm 200 ppm
RESPIRATORY SYSTEM (cOnt'd) Thoracic Cavity (cont'd) Hemorrhage into thoracic cavity
Control
50 ppm 100 ppm 200 ppm
Lungs Small red foci
Control 50 ppm 100 ppm 200 ppm
Atelectatic and edematous
Control 50 ppm 100 ppm 200 ppm
Pneumonia
Control 50 ppm 100 ppm 200 ppm
Golden brown pigment
Control 50 ppm 100 ppm 200 ppm
Diffuse darkened areas throughout lung
Control 50 ppm 100 ppm 200 ppm
Small pale subpleural foci
Control SO ppm 100 ppm 200 ppm
Congestion
Control 50 ppm 100 ppm 200 ppm
URINARY SYSTEM Urinary Bladder Petechial hemorrhage
Control 50 ppm 100 ppm 200 ppm
Thickened wall
Control 50 ppm 100 ppm 200 ppm
Distension with urethral ob struction
Control 50 ppm 100 ppm 200 ppm
1-6 Months
0 0 0 0
7-12 Months
1 0 3 0
13-18 Months
15 5 4
13
19-24 Months
41 25 24 20
Terminal Cumulative
Kill
Results
23 so 18 48 17 48 15 48
0 0 0 0 00 000000 0 0 1 001 0 0 0000
000202 000202 000 101 000 2 02
0004 1 5 000 101 010102 00010 1
0 00 1 0 1 000000 000000 000000
0 00 2 02 000101 000000 000000
001 203 000 101 000 2 02 000101
0 0 l 4 5 10 0004 59 0 1 0 4 5 10 0004 3 7
000000 000 2 0 2 0001 0 1 000000
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082048
TABLE 16 (cont'd)
gross observations of nontumorous changes in female rats
MAINTAINED FOR 24 MONTHS ON WATER CONTAINING VINYLIDENE CHLORIDE
Number of rats autopsied during the time period lndicated
control 50 ppm 100 ppm ZOO ppn
L'RINARY SYSTEM (cant'd) .Sidney Chronic renal disease - minimaL
Control 50 opm 100 oom 200 ppm
Chronic renal disease - moderate
Control 50 ppm 100 ppm 200 ppm
Chronic renai disease - severe
Control 50 opm 100 ppm 200 ppm
Enlarged and congested
Contro L 50 ppm 100 opm 200 ppm
Dilated renal pelvis
Control 50 pom 100 oom 200 opm
Hydronephrosis
Control 50 ppm 100 ppm 200 ppm
Mineralization within renal pelvis Control 50 ppm 100 ppm 200 ppm
Dark and discolored
Control 50 ppm 100 ppm 200 ppm
Renal cysts - not directly idencified with chronic renal disease
Control 50 ppm 100 ppm 200 ppm
White foci
Control 50 ppm 100 ppm 200 ppm
Pale - not associated with chronic Control
renal disease
50 -
107
2C
Red foci
O 5' ir t
200 pom
1-6 Months
o
0
0
u
7-12 Months
i 0 3 0
13-18 Months
15 5 4
13
19-24 Months
41 25 24 20
Terminal Cumulative
Kill
Results
23 80 IS 48 17 48 15 43
c 0 0 5 10 15 1002 3 5
0 0 7 9 16
0 0 2 4 7 13
0 0 1 4 5 10 0 (3 0 4 5 9 0004 1 5 001012
0002 02 n00000 0 10012 0003 03
000000 0002 02
i 00000
00 0 0 0
00 20 0 1
r,( 0 0 0 0 0 00101
0 00000
(. 0 0 0 1 i
000000 000000 000000
0001 0 1 000 20 2 000000 0 00 1 0 1
u (3 1 0 0 1 0 n00 0 0 000000 0 0 00 0 0
0000 2 2 00011 2 000101 000 1 0 1
0 001 0 1 000101 0 00 0 0 0 0 000 0 0
0001 01 000000 0 0 10 0 1 0000 00
000000 0 00 1 0 1 0 00 1 0 1 000000
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082049c
TABLE 16 (cont'd)
GROSS OBSERVATIONS OF NONTUMOROUS CHANGES IN FEMALE RATS MAINTAINED FOR 24 MONTHS ON WATER CONTAINING VINYLIDENE CHLORIDE
Number of rats autopsied during the time period indicated
Control 50 ppm 100 ppm 200 ppm
URINARY SYSTEM (cont'd) Kidney (cont'd) Inflammation sites
Decrease In size
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Renal failure cause of death or poor condition
Control 50 ppm 100 ppm 200 pptn
CARDIOVASCULAR SYSTEM Heart Left atrial thrombosis
Control 50 ppm 100 ppm 200 ppm
Dilated ventricles
Control 50 ppm 100 ppm 200 ppm
Degeneration
Control 50 ppm 100 ppm 200 ppm
Aorta Dilated and Inelastic
Control 50 ppm 100 ppm 200 ppm
Mesenteric Vessels Periarteritis
Control 50 ppm 100 ppm 200 ppm
intra-abdominal cavity Fluid or blood
Control 50 ppm 100 ppm 200 ppm
Adipose tissue depleted (moderate to severe)
Control 50 ppm 100 ppm 200 ppm
1-6 Months
0 0 0 0
7-12 Months
1 0 3 0
13-18 Months
15 5 4
13
19-24 Months
41 25 24 20
Terminal Cumulative
Kill
Results
23 30 13 48 17 48 15 48
000 101 000 000 000 10 1 000 000
00 0000 000 101 000000 000000
00 0 2 0 2 000101 010001 000202
0001 12 000101 000101 000101
00001 i 000000 000000 000000
00002 2 0 0 0 00 0 000000 00001 1
000 707 000000 000000 000 101
0004 3 7 000 2 3 5 0002 13 0 0 1 4 1_ 6
010102 0 00 2 0 2 0 00 0 0 0 000000
004 4 1 9 001203 000404 0 0 2 9 2 13a
Significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082050
TABLE 16 (cont'd)
GROSS OBSERVATIONS OF nontumorous changes IN FEMALE RATS MAINTAINED FOR 24 MONTHS ON WATER CONTAINING vinylidene CHLORIDE
Number of rats autopsied during tne time period indicated
Control 50 ppm LOG ppn
TOO pp'Ti
1-6 Months
0 0 1 0
7-12 Months
1 0 3 0
13-18 Months
15 5 4
13
19-24 Months
41 25
24
20
Terminal Cumulative
Kill
Results
23 80 18 48 17 48 15 48
INTRA-ABDOMINAL CAVITY (cont'd)
0'oe*e
Centro 1
')
0
L
1
0
l
50 ppm J 0 0 0 1 l
LOO ppm
0
1
1
1
0
3
LOO ppm
.)
0
0
1
0
1
GASTROINTESTINAL TRACT
Tongue
Cyst at the base of the tongue
Control
'J
0
0
0
0
0
30 ppm
)00 0 0 0
100 ppm
1
0
0
0
0
0
LOO ppm
1J
0
0
1
0
1
Salivary Gland Salivary gland cyst
control
0
>5
0
0
0
0
50 ppm 0 0 0 0 0 0
LOO ppm
1)
0
0
0
0
0
LOO ppm
0
0
0
1
0
1
^ tomach Gastric cyst
Gcntrol
J
)0000
50 ppm
} 0 00 0 0
100 ppm
i
')
0
0
0
0
200 ppm
'
J0
0
1
1
Gastric distension with air
Control
}
0
0
0
0
0
50 ppm 11 0 0 0 0 0
100 ppm
0
00
L
0
1
LOO jjjjm
0
!000 0
c-astric hemorrhage - focal
Control
,
0
0
0
0
0
50 ppm
J 0 0 0 0
100 ppm
0
0
0
2
0
2
200 ppm
t)
0
0
->
0
2
Gastrointestinal tract devoid of Control
)
0
L
7
0
3
feed and feces
50 ppm It 0 0 1 0 i
100 ppm
')
L
0
2
0
3
4200 ppm
0
0
0
3
1
Gastric ulcers or erosions - focal Control
0
0
1
4
2
7
50 ppm ) 0 0 7 0
100 ppm
0
0
0
3
0
3
4200 ppm
0
0
2
39
Gastric mineralization
Control
0
0
0
0
0
0
50 ppm 0 0 0 0 0 0
100 ppm
0
1
0
0
0
1
200 ppm
0
0
0
0
0
0
Small Intestine
Intussusception of small intestine Control
0
0
0
1
0
1
50 ppm 0 0 0 0 0 0
100 ppm
0
0
0
0
0
0
200 ppm
0
0
0
0
0
0
Mot significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.Q5.
SL 082051
TABLE 16 (cont'd)
GROSS OBSERVATIONS OF NONTUMOROUS CHANGES IN FEMALE RATS MAINTAINED FOR 24 MONTHS ON WATER CONTAINING VINYLIDENE CHLORIDE
Number of rats autopsled during the time period indicated
Control 50 ppm 100 ppm 200 ppm
GASTROINTESTINAL TRACT (cont'd) Larae Intestine Large intestine - parasites
Control 50 ppm
100 ppm 200 ppm
REPRODUCTIVE SYSTEM Ovary Cyst
Control 50 ppm 100 ppm 200 ppm
Inflammation or abscess
Control 50 ppm 100 ppm 200 ppm
Atrophy
Control 50 ppm 100 ppm 200 ppm
Uterus 'Atrophy
Control 50 ppm 100 ppm 200 ppm
Hyperplasia with or without cysts
Control 50 ppm 100 ppm 200 ppm
Dilated uterine horn
Control 50 ppm 100 ppm 200 ppm
NERVOUS SYSTEM Pituitary Gland Hemorrhagic foci
Control
50 ppm 100 ppm 200 ppm
Brain Malscia of brain
Control 50 ppm 100 ppm 200 ppm
Pineal Gland Surrounded by darkened area
Control 50 ppm 100 ppm 200 ppm
1-6 Months
0 0 0 0
7-12 Months
1 0 3 0
13-18 Months
15 5 i
13
19-24 Months
41 25 24 20
Terminal Cumulative
Kill
Results
23 80 18 48 17 48 15 48
001023 0 00000 0 10001 0 000 1 1
0 003 36 00 1 304 0003 3 6 000112
000000 001001 000000 000101
000000 000000 000000 000 101
0 0 1 00 1 000101 000000 000 1 0 1
0 0 1 8 10 19 0 0 0 4 7 11 0 0 0 3 8 11 00043 7
001 1 1 3 000 1 01 000000 00001 1
0004 48 000347 000167 000 2 68
000000 000000 00 0 1 01 000000
000000 000 00 0 000000 0 00 1 0 1
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082052
TABLE 16 (cont'd)
GROSS OBSERVATIONS OF NONTUMOROUS CHANGES IN FEMALE RATS MAINTAINED FOR 24 MONTHS ON WATER CONTAINING V1NYLIDENE CHLORIDE
Number of rats autopsied during the time period indicated
Control 50 ppm 100 ppm 200 ppiji
1-6 Months
0 0 0 0
7-12 Months
i_
0 3 0
13-18 Months
15 h 4
ij
19-24 Months
41 25
20
Terminal Cumulative
Kill
Results
23 tO 1 8 -* 8
i 1 -*8
ENDOCRINE GLANDS ThyroId Decreased in size
White foci
Control
0
0
0
J
0
0
50 ppm 0 0 0 0 0 0
100 ppm
0
0
0
1
J
1
200 ppm
0
0
0
0
0
0
Control
0
0
o
o
0
0
50 ppm 0 0 0 0 0 0
100 ppm
0
0
0
v
0
0
200 ppm
0
0
l
0
0
1
Parathyroid Hyperplasia
Control
0
0
0
l
0
1
50 ppm 0 0 0 0 u 0
100 ppm
0
0
0
0I
200 ppm
0
0
0
-
0
Adrenal Gland
Hemorrhagic surface on cross-
Control
0
0
o
o
0
0
section
50 ppm 0 0 0 1 ; l
100 ppm
0
0
c
2
o
2
200 ppm
0
0
J
')
3
0
Mottled appearance
Control
0
0
1 1 )
4 12
50 ppm
0
0
o
3
: 15
100 ppm
0
0
0 13
7 20
200 ppm
0
0
0 10
4 14
Adrenal gland - atrophy (decrease Control
0
0
0
0
0
0
in size)
50 ppm
0
0
0
0
1
1
100 ppm
0
0
0
0
0
0
200 ppm
0
0
0
0
0
0
INTEGUMENTARY SYSTEM
Keratinized epidermal inclusion
Control
0
0
0
0
1)
0
cyst
50 ppm 0 0 0 0 0 0
100 ppm
0
0
0
1
0
I
ZOO ppm
0
0
0
3
0
0
Mammary gland hyperplasia
Control
0
0
I il
h 18
50 ppm 0 0 0 It
- 10
100 ppm
0
0
0
3
6
9
200 ppm
0
0
0
3
*
7
Galactocele formation
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
0 0 0 0
1. 4
05 04 02
9 18
9 15
Mammary gland - hematocyst
Control
0
0
0
0
l
1
50 ppm 0 0 0 0 0 0
100 ppm
0
0
0
0
L
1
200 ppm
0
0
0
0
0
0
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082053
TABLE 16 (cont'd)
GROSS OBSERVATIONS OF NONTUMOROUS CHANGES in Female RATS MAINTAINED FOR 24 MONTHS ON WATER CONTAINING VINYLIDENE CHLORIDE
Number of rats autopsied during the time period indicated
Control 50 ppm 100 ppm 200 ppm
MUSCULOSKELETAL SYSTEM Skeletal demineralization
Control 50 ppm 100 ppm 200 ppm
Ankylosis of a joint
Control 50 ppm 100 ppm 200 ppm
LYMFHORETICULAR SYSTEM
Lymph Node
Swollen, congested, enlarged and/or edematous - local
Control 50 ppm 100 ppm 200 ppm
Spleen
Splenomegaly - extramedullary hematopoiesis
Control 50 ppm 100 ppm 200 ppm
Splenic atrophy - decrease in size Control 50 ppm 100 ppm 200 ppm
EYE Atrophy
Control 50 ppm 100 ppm 200 ppm
Hemorrhage and ulceration
Control 50 ppm 100 ppm 200 ppm
Corneal ulcer - unilateral
Control 50 ppm 100 ppm 200 ppm
Corneal opacity - unilateral
Control 50 ppm 100 ppm 200 ppm
Corneal opacity - bilateral
Control 50 ppm 100 ppm 200 ppm
1-6 Months
0 0 0 0
7-12 Months
i 0 3 0
13-18 Months
15 5 4
13
19-24 Months
41 25 24 20
Terminal Cumulative
Kill
Results
23 80 18 48 17 48 15 48
00 0000 00 0000 0 1 0001 00 0 101
00 0000 00 0000 0 0 0 00 0 00 0101
00 1 2 03 00 0 1 01 0 0 0 0 00 000213
013419 001405 0 2 2 5 2 11 0 0 3 3 06
0 0 1 001 0 0 000 0 01 0001 000101
00 00 2 2 000011 000011 00 0 000
000000 000000 0 0 0 1 01 000000
00000 0 000000 000101 000000
0 0 104 5 00 000 0 00 01 01 00012 3
0 0 0 3 9 12 00018 9 00 0 2 5 7 00 005 5
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082054
TABLE 16 (conn'd)
GROSS observations of nontumorous changes in female RATS MAINTAINED FOR 24 MONTHS ON WATER CONTAINING VINYLIDENE CHLORIDE
Number of rats autopsicd during the time period indicated EYE (cont'd) Cataracts
GENERAL Postmortem change
Cannibalism
Emaciation
Malocclusion
Jaundice
Anemia
Indurated pale area in muscle of thoracic wall
vontrol j 0 Dpm !00 ppm 200 ppm
1-6 Months
) 0 o ij
7-12 Months
13-13 Mentis
;5
ij
13-24 Mont s
*.
Terminal Cumulative
Kill
Ke a a _13
2 3 SJ 18
15
i,ontro*
:r, 1
1
d0 om
1
100 '7pm
0
u
0
o1
100 ppm
'J
0 '' ) )
Control
}
o
0D
50 ppm
0
0
07
LOo ppm
'
i;
1
2
0
3
200 ..pm
:03
Control
0
i1002
50 ppn
J0
J0 00
100 Dpm
0
1
_
2
0
D
100 ppm
n
0
0
1_
0
i
Centre 0 0
D1l
pQ pp-: 0 f) 0 1 0 1
100 p ;m
0
1
)
1
07
JICO ppm
1
') 7
Control
5C ppm
100 ;?m 200 ppm
J -
j '3
>00
0-0
0` }
00
Cor.trO 1
>
0 l01
30 ppm J 0 J 0 0 0
100 ppm
o J ) 0 0
200 ppm
1
'
001
Control
)
0
2
3
0
7
50 ppm 0 0
) J 1}
3
100 ppm
0
u
-
53
200 ppm
0
0
2
*
Control
)
)
)
1
0i
50 ppm
J
1
00
100 ppm
0
3
2
'
0
200 ppm
0
)
0
Not significantly different from control data wnen analyzed iing FiSimr'i v\act ^r b ibility 2 cbt, <0.05
SL 082055
TABLE 17
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rata autopsied during the time period indicated
1-6 Months
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
LIVER
Centrilobular hepatocellular degeneration Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Centrilobular hepatocellular atrophy
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Hepatocellular atrophy without fatty change
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Periportal hepatocellular hypertrophy
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Hepatocellular atrophy with fatty change
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Centrilobular hepatocellular fatty de generation
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Hepatocellular fatty change, location not specified
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Centrilobular hepatocellular atrophy with fatty change
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Periportal hepatocellular fatty change
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Total number of rats with hepatocellular fatty change or fatty degeneration
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focus of hepatocellular alteration eosinophilic ground glass appearance
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
7-12 Months
1 0 3 0
0 0 0 0
0 0 1 0
0 0 2 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
13-18 Months
15 5 4
13
3 1 1 1
0
4-
1 3
9 0 1 2
1 3 0 6
0 0 0 0
1 0 1 1
0 0 0 4
0 0 0 1
0 0 0 0
1 0 1 6
1 1 1 3
19-24 Months
41 25 24 20
Terminal Cumulative
Kill
Results
23 80 18 48 17 48 15 48
6 4 2 2
10 6 9 5
15 5 5 7
1 3 7 4
1 0 0 2
3 0 o 0
0 4 5 1
0 0 0 2
0 1 1 1
4 5 6 6
7 5 5 1
0 0 0 0
4 1 1 8
13 11
5 4
2 1 4 9
0 0 0 0
0 1 0 1
3 6 6 6
1 0 1 0
0 0 0 3
4 7 7 10
9 9 9 6
9 5 3 3
14 9
12 lb'1
37 16 13 13
4 7 lla 19a
1 0 0
T
4 i i 2
3 ioa lla ll3
1 0 1 3
0 1 1 4a
9 12a 14a 22a
17 15 15 10
Significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082056
TABLE (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
1-6 Months
Control 50 ppm 100 ppm ZOO ppm
0 0 0 'J
7-12 Months
i 0 3 0
13-18 Months
:5
0
4
13
19-24 Months
11 25 21 20
Terminal Cumuli:LVc
Kill
Result=
23 50 18 17 -rh 15 1
LIVER (cent'd)
Focus ofhepatocellular alteration -
Control 0
0
1
2
3
clear cell appearance
50 ppm
0
0
3
100 ppm 0 (3 0 0 2
ZOO ppm 0 0 0 L i
Focus ofhepatocellular alteration -
Control 0
0
0
0
0
0
basophilic appearance
50 ppm
0
0
0
0
0
0
lOQ ppm 0 0 0 0 1 i
ZOO ppm 0 0 0 0 l 1
Area of hepatocellular alteration -
Control 0
0
0
2
2
eosinophilic ground glass appearance
50 ppm
0
00
31
100 ppm 0 0 0
L2
3
ZOO ppm 0 (] 0 0 3 3
Area of hepatocellular alteration -
Control 0
0
0
lj 1
L
basophilic appearance
50 ppm
0
0
0
0
0
0
100 ppm 0 D 0 0 0 0
ZOO ppm 0 0 0 0 0 0
Generalized vacuolization of hepatoevtes Control 0 0 0 i 0 1
50 ppm
0
100 0
100 ppm 0 0 0 ') 0 0
ZOO opm 0
0
,
00
1
Focal hepatic necrosis
Control 0 0 0 2 1 5
50 ppm
0
0
0
3
14
100 ppm 0 0 1 L 0
200 ppm 0 0 0 2 0
Generalized hepatic necrosis
Control 0 0 2 2 0
50 ppm
0
0
0
3
0
3
100 ppm 0 0 1 0 0 1
ZOO ppm 0 0 0 2 u
Increased hematogenous pigment in Control 0 0 3 0 0 0
the reticuloendothelial cells
50 ppm
0
0
0
0
0'
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 2 0
Focal vascular sinusoidal dilatation
Control 0
0
0 14 11
50 ppm
0
0
11
2d
100 ppm 0 0 0
I2
3a
200 ppm 0 0 0 2b 8
Focal vascular dilation with hepato
Control 0
0
Oil
cellular alteration
50 ppm
0
0
0
12
3
100 ppm 0 0 0 L 2 3
200 ppm 0 0 0
01
1
Focal extramedullary hematopoiesis
Control 0
0
2
21
3
50 ppm
0
0
14
0
5
100 ppm 0 1 2
31
7
200 ppm 0 0 1 2 1 4
Significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082057
TABLE 17 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
1-6 Months
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
7-12 Months
1 0 3 0
LIVER (cont'd) Focal biliary hyperplasia
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal periportal fibrosis or sclerosis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Multiloculated biliary cyst formation
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focus of mononuclear inflammatory cells located within the hepatic lobule or portal area
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
RESPIRATORY SYSTEM
Trachea
Focal subepithelial mononuclear inflammatory cell infiltrate
Control 50 ppm 100 ppm 200 ppm
Lungs
Chronic pulmonary lesions characterised by edema, interstitial thickening and fibrosis, inflammatory cell infiltrate and exudation of cells into the alveoli, with or without atelectasis (associated with advanced cardiac or renal lesions)
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
0 0 0 0
Peribronchial mononuclear inflammatory cell infiltrate
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal interstitial pneumonitis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal alveolar histiocytosis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
1 0 3 0
1 0 1 0
0 0 0 0
0 0 3 0
0 0 0 0
0 0 1 0
13-18 Months
15 5 4
13
19-24 Months
41 25 24 20
Terminal Cumulative
Kill
Results
23 80 18 48 17 48 15 48
0123 0 1 i l 0 1 i2 00ii
011 7 0 1 0l 0 10i 2 0 0 LT.
0 6 6 12 0213 04 2 6 0 1 1 2-
15 37 22 75 5 24 17 46 4 24 17 48
12 20 15 47
9 15 24 04 36
03 01 01 01
7 32 8 14 2 7a 4 13
03 01 01 01
15 36 23 74 4 24 18 46 4 23 17 47
13 19 15 47
1 2 03 1001 0101 1113
12 18 14 44 2 13 12 27 2 7 10 20 7 5 6 18
Significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082058
TABLE 17 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
1-6 Months
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
RESPIRATORY SYSTEM (cont'd)
Lungs (cont'd)
Focal
granulomatous
inflammatory
reaction
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal cholesterol cleft formation
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal metaplastic bone formation within the lung
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal mineralization of the interalveolar septae
Control 50 ppm 100 ppra 200 ppm
0 0 0 0
Focal pleural fibrosis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal adenomatous hyperplasia of alveolar lining epithelium
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
URINARY SYSTEM Kidney Minimal degree of chronic nephropathy
Moderate degree of chronic nephropathy
Severe degree of chronic nephropathy
End stage nephropathy
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
7-12 Months
1 0 3 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 1 0
0 0 0 0
0 0 0 0
0 0 1 0
0 0 0 0
0 0 0 0
0 0 1 0
13-18 Months
15 5 4
13
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
1 0 0 0
0 0 0 0
10 4 3
10
2 0 0 1
2 0 1 0
0 0 0 1
19-24 Months
41 25 21 20
Terminal Cumulative
Kill
KesuLts
23 30 13 4ft 17 -3 lo i 5
0 ') J
00
)
0i 1
000
0: n00
01 1 000
101 000 000 00 0
000 00 0 001 000
o01 00
300 000
10 1 000 000 000
27 9 46 19 10 33 15 12 31 10 L0 30
3 10 20 208 538 6 3 10
49 2c4 427
3;3
101 000 001 L 0 >
lata when analyzed using Fisher1s Exact Probability Test, P<0.
SL 082059
TABLE 17 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
1-6 Months
Control 50 ppm I00 ppm 200 ppm
0 0 0 0
LIVER (cont'd) Focal biliary hyperplasia
Focal periportal fibrosis or sclerosis
Multiloculated biliary cyst formation
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focus of mononuclear inflammatory cells located within the hepatic lobule or portal area
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
RESPIRATORY SYSTEM Trachea
Focal subepithelial mononuclear inflammatory cell infiltrate
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Lungs
Chronic pulmonary lesions characterized by edema, interstitial thickening and fibrosis, inflammatory cell infiltrate and exudation of cells into the al~ veoli, with or without atelectasis (associated with advanced cardiac or renal lesions)
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Peribronchial mononuclear inflammatory cell infiltrate
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal interstitial pneumonitis Focal alveolar histiocytosis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppra 100 ppm 200 ppra
0 0 0 0
7-12 Months
1 0 3 0
0 0 0 0
0 0 0 0
0 0 0 0
1 0 3 0
1 0 1 0
0 0 0 0
0 0 3 0
0 0 0 0
0 0 1 0
13-18 Months
15 5 4
13
0 0 0 0
0 0 0 2
0 0 0 0
15 5 4
12
9 2 0 3
0 0 0 0
15 4 4
13
1 1 0 1
12 2 2 7
19-24 Months
41 25 24 20
Terminal Cumulative
Kill
Results
23 80 18 48 L7 48 15 48
123 1 1' 2 1 12 01i
1 12 101 10i 002
6 6 12 213 426 1 12
37 22 75 24 17 46 24 17 48 20 15 47
15 7 32 4 8 14 4 2 73 6 4 13
303 101 101 10 l
36 23 74 24 18 46 23 17 47 19 15 47
203 001 10 1 113
18 14 44 13 12 27
7 10 20 5 6 18
Significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0,05.
SL 082060
TABLE 17 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Mumber of rats autopsied during the time period indicated
1-6 Months
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
RESPIRATORY SYSTEM (cont'd)
Lungs (conn'd)
Focal
granulomatous
inflammatory
reaction
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal cholesterol cleft formation
Control 50 ppm 100 ppm 200 ppm
0 0 0
0
Focal metaplastic bone formation within the lung
Control 50 ppm 100 ppm 200 ppm
0
0 0 0
Focal mineralisation of the interalveolar septae
Focal pleural fibrosis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focal adenomatous hyperplasia of alveolar lining epithelium
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
URINARY SYSTEM Kidney Minimal degree of chronic nephropathy
Moderate degree of chronic nephropathy
Severe degree of chronic nephropathy
End stage nephropathy
Control 50 ppm 100 ppm 200 ppm
0 0
0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
7-12 Months
1 0 2 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 1 0
0 0 0 0
0 0 0 0
0 0 1 0
0 0 0 0
0 0 0 0
0 0 1 0
13-18 Months
15 5 4
13
0 0 u 0
0 0 0 0
0 0 0 0
0 0 0 0
1 0 0 0
0 0 0 0
10 4 3
10
n
0 0 1
2 0 1 0
0 0 0 1
19-24 Months
41 25 24 20
Terminal Cumulative
Kill
RtfSUlt3
53 Sn Id 44 17 ^8 15 48
0 1)
J
00 J
01
00
)
0 000 01 ] 000
l01 000 000 000
000 000 001 000
-) 0 1 )00 100 000
L0 1 000 000 0n0
27 9 46 i 4 10 33 _lC 12 31 10 10 30
3 10 20 2b3 53s b 3 10
4 .) 9 2-4 427
325
101 000 001 102
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05
SL 082061
TABLE 17 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
1-6 Months
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
URINARY SYSTEM (cont'd) Kidney (cont'd) Focal mineral deposit within the kidney
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Focus of mononuclear cell infiltrate
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Multifocal mononuclear cell infiltrate
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Hydronephrosis
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Acute suppurative pyelonephritis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Renal cortical cysts
Control
50 ppm 100 ppm 200 ppm
0
0 0 0
Focal chronic inflammation, infarction. and vascular fibrosis
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Focal cortical abscess
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Glomerular necrosis
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Focal renal cortical tubular hyperplasia
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
7-12 Months
1 0 3 0
0 0 1 0
0 0 1 0
0 0 0 0
0 0 0 0
0 'J 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
13-18 Months
15 5 4
13
5 1 2 4
0 0 1 I
8 0 0 3
1 0 0 0
0 1 0 0
0 0 0 0
0 0 0 0
1 0 0 0
1 0 0 0
1 0 0 0
19-24 Months
41 25 24 20
Terminal Cumulative
Kill
Results
23 80 18 48 17 48 15 48
11 7 ' 23 6 4 11 8 10 21 3 4 11
505 112 002 001
25 14 47 0 10 10* 9 11 20 7 8 18
001 000 101 000
101 102 000 000
022 123 101 101
000 101 000 000
00 1 000 000 00 0
00 1 000 000 000
001 000 000 000
Significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
082062
TABLE 17 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during che time period indicated
1-6 Months
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
URINARY SYSTEM (cont'd) Urinary Bladder Urocystitis
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
GASTROINTESTINAL TRACT
Tongue
Subepithelial focus of mononuclear inflammatory cell infiltrate without a foreign body present
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Subepithelial focus of mononuclear inflaimnatory cell infiltrate with a foreign body present
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Focal granulomatous inflammation without a foreign body present
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Focal granulomatous inflammation with a foreign body present
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Lingual cyst with foreign body granulomatous inflammation
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Atrophy of the lingual serous glands
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
Vascular fibrinoid degeneration
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Focus of parakeratosis and hyperkeratosis
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
7-12 Months
1 0 3 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
13-18 Months
15 5 4
13
1 0 0 0
9 0 0 5
0 0 0 1
2 0 0 0
0 0 0 1
0 0 0 0
1 0 0 3
0 0 0 1
0 0 0 0
19-24 Months
41 25 24 20
Terminal Cumulative
kill
ResuIts
23 30 18 -8 17 48 15 48
0i2 101 000 000
16 15 40 000 000
12 9 26
415 011 000 04 5
7 2 11 000 000 0 1 la
j4 7 000 000 135
101 000 000 0 (3 0
517 000 000 205
'4 3 7 000 000 113
000 011 000 000
aSignificantly different from control data when analyzed using Fisher's Exact Probability Test, p<0,05.
SL 082063
TABLE 17 (coat'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
1-6 Months
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
GASTROINTESTINAL TRACT (cont'd)
Salivary Glands
Focal chronic inf lamination with or without fibrosis
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Atrophy
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Stomach
Submucosal edema of the nonglandular portion
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Focal gastric ulceration and hemorrhage
Control
50 ppm 100 ppm 200 ppm
Hyperplasia and/or hyperkeratosis of the gastric nonglandular epithelium
Control
50 ppm 100 ppm 200 ppm
Mineralization of gastric mucosa
Control
50 ppm 100 ppm 200 ppm
Uremic gastritis
Control
50 ppm 100 ppm 200 ppm
Embryologicmalformation in the glandular Control
portion of the stomach
50 ppm
100 ppm
200 ppm
0
0 0 0
Infarction secondary to mesenteric periarteritis
Control
50 ppm 100 ppm 200 ppm
Large Intestine Intestinal nematodiasis
Control 50 ppm 100 ppm 200 ppm
7-12 Months
i 0 3 0
0 0 0 0 0 0 0 0
0 0 0 0
0 0 0 0
13-18 Months
15 5 4
13
1 0 0 2
0 0 0 1
1 0 0 0
19-24 Months
41 25 24 20
Terminal Cumulative
Kill
Results
23 80 18 48 17 48 15 48
00 1 000 000 002
000 000 000 00 1
001 000 0 00 0 00
15
0 0 6
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082064
TABLE 17 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
1-6 Months
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
7-12 Months
1 0 3 0
13-18 Months
15 5 4
13
19-24 Months
41 25 24 20
Terminal Cumulative
Kill
Results
23 80 18 48 17 -t8 15 48
GASTROINTESTINAL TRACT (cont'd)
Pancreas
Focal atrophy of pancreatic acinar tissue Control 50 ppm 100 ppm 200 ppm
Focal interstitial pancreatitis
Control
50 ppm 100 ppm 200 ppm
0 6 12 12 30 0 0 6 11 17 2 0 5 3 15 0 3 9 6 18
0 5 12 11 28 0 0 6 11 17 1 0 5 9 15 0 3 8 6 17
CARDIOVASCULAR SYSTEM
Heart
Minimal degree of focal myocardial de
Control 0
1
7 22 13 43
generation and fibrosis
50 ppm
0
0
1 19 14 34a
100 ppm 0 1 3 15 12 31
200 ppm 0 0 6 11 9 26
Moderate degree of focal myocardial de
Control 0
0
2* 9
7 18
generation and fibrosis
50 ppm
0
0
0
3
2
5
100 ppm 0 0 0 6 2 8
200 ppm 0 0 0 3 2 5
Severe degree of focal myocardial de
Control 0
0
0
3
0
3
generation and fibrosis
50 ppm
0
0
0
0
0
0
100 ppm 0 1 0 0 0 1
200 ppm 0 0 1 1 0 2
Left atrial thrombosis Endocardial fibroelastosis
Control 0
0
0
1
l
2
50 ppm
0
0
0
1
0
1
100 ppm 0 0 0 1 0 1
200 ppm 0 0 0 0 0 0
Control 0 0 0 0 1
L
50 ppm
0
0
0
L
0
1
100 ppm 0 0 1 0 0 1
200 ppm 0 0 0 0 0 0
Focal myocardial mineralization
Control 0 0 0 l 0 1
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 1 0 0 1
Aorta Aortic mineralization
Enlarged aortic body
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
0011 2 002 02 10203 01001
00 0 00 00000 00 0 00 001 01
using Fisher'1s Exact Probability Test, p<0.05.
SL 082065
TABLE 17 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
CARDIOVASCULAR SYSTEM (cont'd) Mesenteric and Other Vessels periarteritis and sclerosis
Hyalinization, sclerosis, and/or fibrinoid degeneration suggestive of periarteritis
Mineralization
REPRODUCTIVE SYSTEM Ovary Ovarian cyst formation
Chronic suppurative oophoritis and/or salpingitis
Uterus Multiple areas of cystic endometrial
hyperplasia
Atrophy of uterus
Chronic suppurative exudate within uterine horn
Squamous metaplasia of uterus with or without keratinization
Chronic suppurative cervicitis
1-6 Months
Control 50 ppm 100 ppm 200 ppm
0 0 0
0
7-12 Months
1 0 3 0
13-18 Months
15 5 4
13
19-24 Months
41 25 24 20
Terminal Cumulative
Kill
Results
23 80 18 48 17 48 15 48
Control 0
1
12
6 10
50 ppm
0
0
0 12
3
100 ppra 0
0
02
24
200 ppm 0 0 2 5 2 9
Control 0 0 0 5 6 11
50 ppm
0
0
0
15
6
100 ppm 0 0 0 2 3 5
200 ppm 0 0 1 5 1 7
Control 0 0 0 10 1
50 ppm
0
0
0
0
0
0
100 ppm 0 1 0 0 1 2
200 ppm 0 0 0 0 0 0
Control 0 0 0 5 5 10
50 ppm
0
0
13
15
100 ppm 0 0 0 5 2 7
200 ppm 0
0
112
4
Control 0 0 0 10 1
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 11 2
Control 0 0 1 9 13 23
50 ppm
0
0
0
4
5
9
100 ppm 0 0 0 5 9 14
200 ppm 0 0 1 3
48
Control 0 0 0 0 0 0
50 ppm
0
0
0
0
1
1
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 10 1
Control 0
0
0 10
1
50 ppm
0
0
00 0
0
100 ppm 0
0
00
0
0
200 ppm 0 0 Oil 2
Control 0 0 0 15 6
50 ppm
0
0
0
0
2
2
100 ppm 0 0 0 0 5 5
200 ppm 0 0 10 1 2
Control 0 0 0 10 1
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 0 0 0
Not'significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082066
TABLE 17 (cont'd)
HISTOPATHOLOGIC LESIONS IN FEMALE RATS MAINTAINED ON WATER CONTAINING VTNYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
1-6 Months
Control
50 ppm 100 ppm 200 ppm
0
0 0 0
7-12 Months
1 0 3 0
13-18 Months
15 5 4
13
19-24 Months
41 25 24 20
Terminal Cumulative
Hill
Results
23 80 18 48 17 48 15 48
NERVOUS SYSTEM AMD ENDOCRINE SYSTEM
Srain Focal malaria of the brain
Control 0 0 1' 2 0 3
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 1 0 1
Focal myelin vacuolation in cerebrum
Control 0
0
0
0
0
0
and cerebellum
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 1 0 1
200 ppm 0 0 0 0 0 0
Spinal Cord Vacuolization of myelin
Control 0 0 2 12 22 36
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 2 6 14 22
Peripheral Nerves Vacuolization of myelin
Control 0 0 1 17 22 40
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 3 5 14 22
Pituitary Gland Sinusoidal dilatation
Hyperplastic focus
Hematocyst formation
Control 0 0 0 -> 5 5
50 ppm
0
0
0
0
1
1
100 ppm 0 0 1 1 1 3
200 ppm 0 0 0 1 2 3
Control 0 0 0 2 1 3
50 ppm
0
0
0
2
1
3
100 ppm 0 0 0 L 2 3
200 ppm 0 0 1 0 1 2
Control 0 0 0 1 0 1
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 0 0 0
Adrenal Glands Hematocyst formation
Control 0 0 5 25 14 44
50 ppm
0
0
3 14 12 29
100 ppm 0 1 3 19 15 38'
200 ppm 0 0 3 14 11 28
Focal lipomatosis of the adrenal cortex Control 0 0 1 17 5 23
50 ppm
0
0
1
5
7 13
100 ppm 0 0 0 8 7 15
200 ppm 0 0 0 6 5 11
aSignificantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.Q5.
SL 082067
TABLE 17 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
1--6 Months
Control
50 ppm 100 ppm 200 ppm
0 0
0 0
NERVOUS SYSTEM (cont'd) Adrenal Glands (cont'd) Focal hyperplasia of the adrenal cortex
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Focal hyperplasia of the adrenal medulla
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Thyroid Gland Focal hyperplasia of C cells
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Parathyroid Gland Parathyroid hyperplasia
Control
50 ppm 100 ppm 200 ppm
0
0 0 0
SUBCUTANEOUS TISSUE, MAMMARY GLAND AND INTEGUMENT
Mammary Gland
Mammary gland hyperplasia
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Mammary glandgalactocele formation
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Mammary gland cyst
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Mammary gland abscess
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Epidermal Inclusioncyst
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
7-12 Months
1 0 3 0
13--18 Months
15 5 4
13
19--24 Months
41 25 24 20
Terminal Cumulative
Kill
Results
23 80 18 48 17 48 15 48
6 5- 11
32
5
20
2
02
2
3 8 11
11
2
3 14
12 3
459
36
9
25 7
348
31
5
112
30
4
30
4
10 9 20 438 6 7 14 5 3 10
358 6 3 10 43 8 2 35
Oil 0 00 0 00 0 00
0 00 0 00 0 L1 0 00
Oil
0 00
10
1
0 00
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082068
TABLE 17 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIOHS IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
1-6 Months
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
7-12 Months
1 0 3 0
13-18 Months
15 5 4
13
19-24 Months
41 25 24 20
Terminal Cumulative
Kill
Results
23 80 18 48 17 48 15 48
SUBCUTANEOUS TISSUE, MAMMARY GLAND AND INTEGUMENT (cont'd)
Mammary Gland (cont'd)
Subcutaneous abscess in the midcervical Control 0 0 i 0 0 1
region
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 0 0 0
Clitoral gland abscess
Control 0 0 0 1 0 1
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 0 0 0
MUSCULOSKELETAL SYSTEM Skeletal Muscle Atrophy
Control 0 0 4 9 10 23
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 1 8 6 15
Chronic ankylosing arthritis of a rear
Control 0
0
0
0
0
0
limb
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 1 0 1
EYES Chronic focal keratitis
Cataract
Control 0 0 2 0 1 3 500 ppm 0 0 0 0 0 0
100 ppm 0 0 0 0 0 0 200 ppm 0 0 0 0 0 0
Control 0 0 0 0 0 0
50 ppm
0
0
0
1
0
1
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 0 0 0
ADIPOSE TISSUE Atrophy of mediastinal fat
Intraabdominal fat necrosis
Control 0 0 1 9 2 12
50 ppm
0
0
1
1
1
3
100 ppm 0 1 0 2 0 3 200 ppm 0 0 2 7 1 10
Control 0 0 0 i 0 1
50 ppm
0
0
0
0
0
0
100 ppm 0 0 0 0 0 0
200 ppm 0 0 1 0 0 1
lymphoreticular SYSTEM Mediastinal Lymphoid Tissue Hematogenous pigment deposits
Control 0 0 1 3 I 5
50 ppm
0
0
0
1
1
100 ppm 0 0 0 0
0
200 ppm 0 0 0 1
1
Not Significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082069
TABLE 17 (cont'd)
NONTUMOROUS HISTOPATHOLOGIC LESIONS IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
1-6 Months
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
LYMPHORETICULAR SYSTEM (cont'd) Mediastinal Lymphoid Tissue (cont'd) Atrophy
Hyperplasia
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Mesenteric Lymph Nodes Sinusoidal vascular dilatation
Hyperplasia
Atrophy
Edema
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Other Lymph Nodes Hyperplasia
Control
50 ppm 100 ppm 200 ppm
0 0 0 0
Spleen Atrophy of spleen with or without hemo-
siderin pigment
Increased hemosiderin deposits within the spleen
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
0 0 0 0
7-12 Months
i 0 3 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
1 0 0 0
0 0 0 0
0 0 1 0
0 0 0 0
13-18 Months
15 5 4
13
1 0 0 0
1 1 0 0
1 0 0 0
1 0 0 0
0 0 0 0
0 0 0 0
1 0 0 1
5 0 0 3
0 0 0 1
19-24 Months
41 25 24 20
Terminal Cumulative
Kill
Results
23 80 18 48 17 48 15 48
203 000 000 000
203 304 000 000
0 01 0 00 0 00 0 00
001 0 00 1 01 0 00
1 01 0 00 000 000
203 112 0 00 0 00
2 14 000 000 001
7 1 13 404 102 8 0 11
000 000 000 001
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082070
TABLE 17 (cont'd)
NONTUMQROUS HISTOPATHOLOGIC LESIONS IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
1-6 Months
Control
50 ppm 100 ppm 200 ppm
0
0 0 0
7-12 Months
1 0 3 0
13-18 Months
15 5 4
13
19-24 Months
41 25 24 20
Terminal Cumulative
Kill
Results
23 80 13 48 17 48 15 48
LYMPHORETICULAR SYSTEM (coat'd) Spleen (cont'd) Hyperplasia
Control 0 0 1 0 0 1
50 ppm
0
0
1
2
1
4
100 ppm 0 0 0 0 0 0
200 ppm 0 0 0 0 0 0
Increased extramedullary hematopoiesis in Control 0 1 7 23 6 37
spleen
50 ppm
0
0
2 11
2 15
100 ppm 0 2 3 6 8 19
200 ppm 0 0 6 7 2 15
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.l
SL 082071
TABLE 18
TUMOR OR TUMOR-LIKE LESIONS GROSSLY RECOGNIZED IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
Control 50 opm 100 com 100 ppm
liver
Nodular proliferation in liver primary site
Control 50 opm 100 ppm LOG ppm
Nodular proliferation in Liver metastatic foci
Diffuse tumor infiltrate and enlarged - associated with lymphoid proliferation
Control 50 ppm 100 pom LOO ppm
Contro1 30 ppm 100 ppm 200 ppm
kidney
Tumor - primary site
Control 30 ppm 100 ppm 200 ppm
Tumor - metastatic lesion
Control 50 ppm 100 ppm 2C0 ppm
RESPIRATORY SYSTEM Lungs Focal nodule of metastatic tumor
Control 50 ppm 190 ppm 200 ppm
GASTROINTINESTINAL TRACT
Proliferative Lesion involving the tongue
Control 50 ppm 100 ppm 200 ppm
Small intestinal tumor or diverticulum
Control 50 ppm 100 ppm 200 ppm
Large intestinal tumor Pancreatic nodule - primary site
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
1-6
Months
0 0 0 0
7-12 Months
1 0
3
0
13-18 Months
15 5 4
13
19-24 Months
41 25 24
20
Terminal Cumulative
Kill
Results
23 30
13 ^8 17 48 15 -3
00i 102
0
0
0
1
1
2
00 0000
00 1 02 3
0 0 0 101 0 0 0 000 0 0 0 00 0 0 0 0 00 0
00 0 202 00 0 000 00 0000 00 0000
01 0001 00 0000 000011 000000
0 ') 0 0 0 0 0 31001 0 ; 0000 3 30000
01010 000000 000000 001001
0U00L 1 0 0 0 0 00 000 101 0 0 1 3 04
000 000 00001 1 0 0 0 112 000000
0 0 00 00 0 000 0 0 0 001 0 1 0 000 0 0
0 0 03 3 6 0 0 0000 0 0 020 2 0 0 Oil 2
Not significantly different from control data when analysed using Fisher's Exact Probability Test, p<0.05.
SL 082072
TABLE 18 (cont'd)
TUMOR OR TUMOR-LIKE LESIONS GROSSLY RECOGNIZED IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
Control
50 ppm 100 ppm 200 ppm
GASTROINTESTINAL TRACT (cont'd)
Pancreatic nodule - metastatic lesion
Control
50 ppm 100 ppm 200 ppm
REPRODUCTIVE SYSTEM Ovarian tumor
Uterus - endometrial polyp(s) - number of animals with polyp(s)
Uterus - tumor - primary site
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Uterus - tumor - metastatic lesion Control 50 ppm 100 ppm 200 ppm
Cervix tumor
Control
50 ppm 100 ppm 200 ppm
PITUITARY GLAND
Pituitary gland - increased in size
Control
50 ppm 100 ppm 200 ppm
thyroid gland
Thyroid increased in size
Control
50 ppm 100 ppm 200 ppm
ADRENAL GLAND Enlarged - unilateral
Control
50 ppm 100 ppm 200 ppm
Enlarged - bilateral
Control
SO ppm 100 ppm 200 ppm
1-6 Months
0 0 0 0
7-12 Months
1 0 3 0
13-18 Months
15 5 4
13
19-24 Months
41 25 24 20
Terminal Cumulative
Kill
Results
23 80 18 48 17 48 15 48
0 0 0 I fl 1 000 0 0 0 0000 00 000000
000n 02 0000 1 1 000000 0 00 i0 1
0 0 0 8 8 16
0 0 0 4 11 15 0006 17 0 0 4 4 4 12
0001 34 000i 1 2
000i 01 00020 2
0000 0 0
00n
)00
0 0 0 j 0 0
000
01
0 00 i 0 2 000 101 000 0 0 0 00i00 L
0 0 4 11 9 24 0 0 0 8 8 16 0 0 2 3 6 16 0 0 2 5 3 10
0003 1 4
000 I 2 3
0001 1 2
000
i5
0 0 1 13 2 16 000 3 58 001 6 18 000 5 4 9
0013 15 0000 i1 000000 000 0 00
Not significantly different from control data when analyzed using Fisher''s Exac t 'Probability Test, p<0,
SL 082073
TABLE 18 (cont'd)
tumor or tumor-like lesions grossly recognized in FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
Control BO ppm 100 ppm 200 ppm
MUSCULO SKELETAL SYSTEM Boney proliferation of mandible
Control
50 ppm 100 ppm 200 ppm
lymphoreticular system
Lymph node - tumor consisting of lymphoid tissue
Local invasion of tumor with regional lymph node involved
Thymus enlarged
Splenomegaly - tumor related
Control 50 ppm 100 ppm 200 ppm
Contro l 30 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
integumentary system
Subcutaneous tumors - mammary and midcervical region
Control
50 ppm 100 ppm 200 ppm
Subcutaneous tumor - eye, ear and head region
Control
50 ppm 100 ppm 200 ppm
Subcutaneous tumor - body/limb
Control
50 ppm 100 ppm 200 ppm
MISCELLANEOUS Nodule in omentum
Control
50 ppm 100 ppm 200 ppm
Intra-abdominal tumor - origin uncertain
Control
50 ppm 100 ppm 200 ppm
1-6 Months
0 0 0 0
7-12 Months
1 0 3 0
13-18 Months
13 5 4
13
19-24 Months
41 23 24 20
Terminal Cumulative
Kill
Results
23 80 18 13
17 48 15 43
0000 L
00 0000 00 0000 00 0000
001j04 00001 1 0 0 0 00 0 00 000 0
0 1 1 204 000101 0 0 0 0 11 00 100i
0 0 0 1 0i 00 0000 00 0000 0 0 0000
0 J0202 0 , 0 0 0 (J 0 J 0 0 0 0 0 0000
0
0
11/9a
64/33a
29/17a 104/593
0
0
9/5a
4 3/2 2a
19/13a
71/40d
0
2/2a
2/2a
45/233
19/103
68/37d
0
0
12/9a
22/ 12a
30/15a
64/3 6 a
001001 00 0 10 1 000112 000 10 i
000000
000000 00001 1 000000
000101 000000 000000 000000
00 0000 00010 1 000000 000000
Not significantly different from control data when analyzed using Fisher's Exact Probability Test aNunber of tumors/number of animals with tumors.
p<0.05.
SL 082074
TABLE 19
HISTOPATHOLOGIC DIAGNOSIS AND NUMBER OF TUMORS IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rata autopsied during the time period indicated
Control 50 ppm 100 ppm 200 ppm
LIVER
Neoplastic nodule (hepatocellular hyperplastic nodule)
Control
50 ppm 100 ppm 200 ppm
Hepatocellular carcinoma without metastasis
Control
50 ppm 100 ppm 200 ppm
URINARY SYSTEM
Kidney
Renal tubular adenocarcinoma with pulmonary metastasis
Control
50 ppm 100 ppm 200 ppm
Renal tubular adenoma
Control
50 ppm 100 ppm 200 ppm
Renal hemangioma
Control
50 ppm 100 ppm 200 ppm
GASTROINTESTINAL TRACT Tongue Keratoacanthoma
Control
50 ppm 100 ppm 200 ppm
Squamous cell carcinoma without metastasis
Control
50 ppm 100 ppm 200 ppm
Hard Palate
Squamous cell carcinoma without metastasis
Control
50 ppm 100 ppm 200 ppm
Salivary Gland Hemangioma
Control 50 ppm 100 ppm 200 ppm
1-6 Months
0 0 0 0
7-12 Months
1 0 3 0
13-18 Months
L5 5
13
19-24 Months
41 25 Z-, 20
Terminal Kill
23 L8 17 15
Cumulative Results
80 48 48 48
000 I 0i
00 )0 L2
0000 00
000
L>
0 0 [) 0 0 0
000000 000 0 00
00100i
0100 0 1
000 0 0 0
000 0 0 0
0000 0 0
0000 0 0
0000 0 0 0 0 II 0 I 1 00 } )0 0
00 0
) (J 0
000 ;0 1
00000 0
000 1 0 1
0001 0 1
000000 00000 0 0001 0 1
0 0 0 (J
1
000000
00010 I
0 0 1, 2 t) 3
0 0 ') 0 0 0 0 0 l) 0 0 0 0 0 0 ]_ 0 1 000u00
000000 000 0 00 000000 0000 11
Not significantly different from control data when analyzed using Fisher 's Exact Probability Test, p<0.05.
0820^5
SL
TABLE 19 (cont'd)
HISTOPATHOLOGIC DIAGNOSIS AND NUMBER OF TUMORS IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
Control
50 ppm 100 ppm 200 ppm
GASTROINTESTINAL TRACT (cont'd)
Esophagus
Squamous call carcinoma without metastasis
Control 50 ppm
100 ppm 200 ppm
Small Intestine
Mucinous cystadenocarcinoma without metastasis
Control
50 ppm 100 ppm .00 ppm
Leiomyosarcoma without me* tastasis
Control
50 ppm 100 ppm 200 ppm
Large Intestine Adenocarcinoma
Control
50 ppm 100 ppm 200 ppm
Pancreas Acinar adenoma
Control
50 ppm 100 ppm 200 ppm
Islet cell adenoma
Control
50 ppm 100 ppm 200 ppm
REPRODUCTIVE SYSTEM
Ovary
Granulosa cell tumorwithout metastasis
Control
50 ppm 100 ppm 200 ppm
Leiomyoma
Control
50 ppm 100 ppm 200 ppm
Lipoma of themesovarium
Control
50 ppm 100 ppm 200 ppm
1*6 Months
0 0 0 0
7-12 Months
1 0 3 0
13-18 Months
15 5 4
13
19*24 Months
41 25 24 20
Terminal Kill
23 18 17 15
Cumulative Results
80 48 48 48
0 0 00 0 0 0 00 0 0 0 00 1 0 0 00 0
0 0
1 0
0 0 00 0 0 0 00 1 0 0 0 10 0 0 00 0
0 0 00 0 0 0 00 0 0 0 00 1 0 0 00 0
0 1 1 0
0 0 1 0
0 0 00 0 0 0 00 0 0 0 0 10 0 0 00 0
0 0 1 0
0 0 00 0 0 0 00 0 0 0 00 0 0 0 0 10
0 0 0 1
0 0 0 14
5
0 0 00 1
1
0 0 Oil 2
0 0 0 16
7
0 0 00
00
0 0 Oil 2
0 0 00
00
0 0 00
00
0 0 0 10
1
0 0 00
00
0 0 00
00
0 0 00
00
0 0 00
00
0 0 00
00
0 0 00 0 0
0 0 0 10
1
Not significantly different from control data when analyzed using Fisher's Exact Probability Test, p<0.05.
SL 082076
TABLE 19 (cone'd)
HISTOPATHOLOGIC DIAGNOSIS AND NUMBER OF TUMORS IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR Ik MONTHS
Number of rats autopsied during the time period mi l cated
Control
50 npm
100 ppm 200 ppm
RErRODL CTI\E SYSTEM
Ovary coat'd)
Stromal -sarcoma of the ovary without metastasis
Contro1
50 ppm
100 ppm 200 ppm
lterus Endometrial polyps
Control
50 ppm
100 ppm 200 ppm
Squamous papilloma of the endometrium
Control 50 ppm
100 ppm 200 ppm
Uterine adenocarcinoma without metastasis
Control
50 opm
100 ppm 200 ppm
Endometrial medullary carclnoma with metastasis to urinary bladder, lymph nodes, and small intestine
Control
50 ppm
100 ppm 200 ppm
Leiomyosarcoma without metastasis
Control
50 ppm
100 ppm 200 ppm
Stromal sarcoma of uterus or cervix without metas is
Control
50 ppm
100 ppm 200 ppm
Stromal sarcoma of uterus or cervix with intraabdominal metastasis
Control
50 ppm
100 ppm 200 ppm
Cervix Fibroma
Control
50 ppm
100 ppm
200 ppm
NERVOUS SYSTEM AND ENDOCRINE GLANDS
1-6
Months
0 0
0
0
7-12
Months
1 0
5
0
13-18 Months
j.C
4 13
19-21 Months
23
2-f 20
Terminal
_5 13 17 i5
Cumulative Results
50 -3 13 +3
000 )0 0 0 j_ 0 0 1 0 '5 Q 0 0 0 0 0000
0 0 0 12 9 21 0 0 0 5 9 14 0006 59 0 0 -f 7 1 15
000000 000000 000000 000101 000: I3 0 0 f) 0 0 0 000000 000000
000
01
0 u 0 J 0 0
000
00
0 0 00
000o00 0001 12 000000 000000
0000 1 1 0002 0 2 0001 0 l 000000
0010 1 i 000000 000000 000000
000o00 000000 0000o0 001001
Astrocytoma
Control 50 ppm 100 ppm 200 ppm
Not significantly different from control data when analysed using FisherS Exact Probability Test, p<0.05.
J,
SL 082077
TABLE 19 (cont'd)
HISTOPATHOLOGIC DIAGNOSIS AND NUMBER OF TUMORS IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the time period indicated
Control 50 ppm 100 ppm 200 ppm
NERVOUS SYSTEM AND ENDOCRINE GLANDS
Pituitary Gland
Adenoma
Control 50 ppm 100 ppm 200 ppm
Carcinoma without brain invasion
Control 50 ppm 100 ppm 200 ppm
Carcinoma with brain invasion
Control
50 ppm 100 ppm 200 ppm
Adrenal Gland
Adenoma of the adrenal cortex
Control
50 ppm 100 ppm 200 ppm
Pheochromocytoma, unilateral
Control
50 ppm 100 ppm 200 ppm
Pheochromocytoma, bilateral
Control
50 ppm 100 ppm 200 ppm
Thyroid Gland C-cell adenoma
Control 50 ppm 100 ppm 200 ppm
C-cell carcinoma without metastasis
Control 50 ppm 100 ppm 200 ppm
MUSCULOSKELETAL SYSTEM
Osteogenic sarcoma of the mandible without metastasis
Control
50 ppm 100 ppm 200 ppm
1-6 Months
0 0 0 0
7-12 Months
1 0 3 0
13-18 Months
15 5 4
13
19-24 Months
41 25 24 20
Terminal Kill
23 18 17 15
Cumulative Results
80 48 48 48
0 0 3 12 9 24 0 0 0 12 11 23a 0 0 2 6 9 17 0 0 1 5 8 14
00 0 10 1 00 002 2 00 010i 00010i
00 2 103 0000 00 00 0 1 01 00 0000
0 0 0 1 01 00 0011 0 0 0000 00 0000
0002 3 5 00002 2 00 0 101 000101
00 0 1 01 00 0 0 1 1 00 0 01 1 00 0 0 0 0
00 034 7 000347 001 326 0002 35
0000 1 1 0000 00 000101 000101
0 0 001 1 0 0 00 00 00 0000 0 0 000 0
aSignificantly different from control data when analyzed using Fisher' s Exact Probability Test, p<0.05.
SL 082078
TABLE L9 (cant'd)
HISTOPATHOLOGIC DIAGNOSIS AND NUMBER OF TUMORS IN FEMALE RATS MAINTAINED ON WATER CONTAINING VINYLIDENE CHLORIDE FOR 24 MONTHS
Number of rats autopsied during the cime period
indicated
Control 50 p-pm LUO ppm 500 ppm
1-6
Months
0 0 ) 0
7-12 Months
]. 0 j 0
13-18 Months
15
* 13
19-24 Months
41 23 22'1
Terminal Kill
n
13 j_ /
1;
Cumulative Results
80 _Q
-8
LYMP-ORETICULAR SYSTEM
Generalized Lymphosarcoma with widespread tissue involvement
Contra I 30 ppm luO ppm 200 ppm
Lymphosarcoma of the mesenCeric: lymph nodes
Control 50 ppm 100 npm 200 ?pm
Lymphosarcoma involving 3 hind limb without metastasis
Control 30 ppm 100 ppm 200 ppm
INTEGUMENTARY SYSTEM Subcutaneous lipoma
Contra I 50 ppm 100 ppm 200 ppm
Subcutaneous fibrosarcoma with muscle invasion and Lvmoh node metastasis
Control 50 ppm LOU ppm 1Q0 ppm
Myxofibrosarcoma of the abdommul wall without me castas!s
Control 50 ppm 100 npm 200 ppm
Undifferentiated fibrosarcoma Control
of the rear leg without
30 ppm
metastasis
100 00m
200 ppm
Mammary gland fibroadenoma/ adenofibroma
Control 50 ppm 100 ?pm 200 ppm
Mammary gland adenoma
Control 50 ppm 100 ppm 200 ppm
Mammary gland adenocarcinoma without metastasis
Control 50 ppm 100 ppm 200 ppm
Mammary gland malignant fibrous histiocytoma
Control 50 ppm 100 ppm 200 ppm
Sebaceous squamous cell carcinoma of the external ear canal gland (Zymbal gland) without metastasis
Control 50 ppm 100 ppm 200 ppm
0 0 0 0
,,) 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
u 0 2 j _
000 G0
3 0 0 j )
J1
000 00 ,0U 1 1 000 00 0 0 0 0 (3
000 00 0 0 0 13 0 000 11 00 0 00
) (}
0 0
0 0 0 0
0
)
0 0
0 0 0 0
0 0 l/la 0
0 0 0 0
0 0 l/l3 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
10/8a
9/K
3/2a 11/8 J
0 0 0 0
0 0 0 0
0 0 0 0
1 0 0 0
i/ia Ij 0 0
i/la 0 0
,
*,la J 3
j 0 0 0
551/30^ 39/22a 39/ 22a 25,13a
0 0 0 0
i,3a I/la l/l"
0
0 0 0 0
0 1 1 1
0
n
0 0
0 0 0 0
0 0 0 0
0 0 l/la 0
25/16a I8/13a 19/Ila 28/14j
0 0 l/la 0
l/la 0 0 0
0 0 l/la 0
0 0 0 0
l/la 0 0 0
1/La 0 0 0
0 L/la
0 0
0 0 l/la 0
96/54a 66/40a 62/36a 64/35a
0 0 l/la 0
4/4a
iLn/1l
0
0 0 1/Ia 0
1 1 1 1
Mot significantly different from control data when analysed using Fisher' s Exact Proban* .: - 2 Test p<0.05.
^Number of tumors/number of an Inals with tumors.
J
Si
82079
TABLE 20
NUMBER OF FEMALE RATS FOR WHICH THE SPECIFIED TISSUE WAS EXAMINED MICROSCOPICALLY (Rats Maintained for 24 Months on Water Containing VInylidene Chloride)
Number of rats autopsied during the time period indicated Liver Kidney Heart Pancreas Spleen Lung Skeletal Muscle Mediastinal Lymphoid Tissue Mediastinal Fat Salivary Glands Aorta Esophagus
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppra 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
1-6 Months
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
7-12 Months
1 0 3 0
1 0 3 0
1 0 3 0
1 0 3 0
1 0 3 0
1 0 3 0
1 0 3 0
0 0 0 0
1 0 2 0
0 0 3 0
1 0 0 0
1 0 3 0
1 0 3 0
13-18 Months
15 5 4
13
19-24 Months
41 25 24 20
Terminal Cumulative
Kill
Results
23 30 18 48 17 48 15 48
15 41 5 25 4 24
13 20
15 41 5 24 4 24
13 20
15 41 5 25 4 24
13 19
13 39 5 24 4 24
13 19
15 40 5 25 4 23
13 20
15 41 5 25 4 24
13 20
11 41 00 01
12 18
14 40 5 23 3 24
13 19
14 38 5 24 4 24
12 19
10 40 00 01
11 19
13 37 5 25 3 24
13 17
13 38 5 25 4 22
13 18
23 18 17 . 15
23 18 17 15
23 18 17 15
23 18 17 15
23 18 17 15
23 18 17 15
22 0 0
14
22 18 17 14
22 16 15 15
18 0 1
13
22 15 16 15
21 18 17 15
80 48 48 48
80 47 48 48
80 48 48 47
76 47 48 47
79 48 47 48
80 48 48 48
74 0 1
44
77 46 46 46
74 45 46 46
69 0 2
43
73 45 46 45
73 48 46 46
SL 082080
TABLE 20 (cont'd)
number of female rats FOR WHICH THE SPECIFIED TISSUE WAS EXAMINED microscopically (Rats Maintained for 24 Months on Water Containing Vinylideine Chloride)
Number of rats autopsied during che time period indicated Trachea Parathyroid
Thyroid Stomach Small Intestine
Large Intestine Mesenteric Lymph Node Mesenteric Vessels Urinary Bladder Uterus Ovary Oviduct
Contro] 30 y.
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control. 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 500 ppm 100 ppm 200 ppm
1-6
Months
0 0 0 0
0 0 0 0
0 0 0 0
0 0
0
0
0 0 0
0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
7-12 Months
1 0 1 0
]_ )
2
J
0
)
0
1
U ) (j
0 0
3
0
j
0 0
;j
0 0 0
0
L
0 0 0
0 0 0
0
1 0 -) 0
0 0 2 0
0 0 2 0
0 0 2 0
13-18 Months
15 5 -4
13
U
4 13
i3 4 J
12
1a 4 4
Id
15 5 4
13
15
0 0 12
14 (!
0
a. J
14
0 0
12
12
0
1
ii
14
1 0
13
15 i
0
13
15
2 0 12
15
2 0
13
19-24 Months
41 ,,) 24
20
Terminal Cumulative
Kill
Rt-su ' ts
23 80 18 1 ' 48 L 5 48
4 0 ) i 73 25 26 4 b 24 17 4 7 19 15 47
30 23 o7 23 44 21 4 3 39 26 i 4 4 1
3 7 23 75 25 L8 47 24 17 47 20 15 48
41 23 79 24 18 47 22 16 45 20 15 48
40 23 79 022 3 14 - - 15 46
. J 23 77 )00
_02 i8 15 46
39 22 76
163
5 58 17 13 42
36 20 68 145 337
17 10 38
41 23 79 13 14 28 13 13 28 18 13 44
41 23 79 13 15 29 12 13 27 19 14 46
41 23 79 13 15 30 13 13 23 18 14
40 23 ; 13 15 3' 13 13 2c 17 14 44
SL 082081
TABLE 20 (cont'd)
NUMBER OF FEMALE RATS FOR WHICH THE SPECIFIED TISSUE WAS EXAMINED MICROSCOPICALLY (Rats Maintained for 24 Months on Water Containing Vinylidene Chloride)
Number of rats autopsied during the time period indicated Peripheral Nerve Spinal Cord Pituitary Gland
Adrenal Gland Cerebellum Cerebral Cortex
Eyes Tongue Skin Mediastinal Vessels Clitoral Gland Pineal Gland
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
1-6 Months
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
7-12 Months
1 0 3 0
0 0 0 0
0 0 0 0
1 0 2 0
1 0 3 0
1 0 3 0
1 0 3 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
13-18 Months
15 5 4
13
10 0 0 12
13 0 0
12
14 3 4
ii
15 5 4
13
14 5 4
13
14 5 4
13
5 0 0 4
9 0 0 7
3 0 0 1
0 0 0 1
0 0 0 0
0 0 0 0
19-24 Months
41 25 24 20
Terminal Cumulative
Kill
Results
23 80 18 48 17 48 15 48
3b 23 69 000 000
18 15 45
39 23 75 000 000
19 15 46
38 23 76 23 18 44 23 17 46 16 15 42
41 23 80 24 18 47 24 17 48 20 15 48
41 23 79 25 18 43 23 17 47 19 15 47
41 23 79 25 18 48 23 17 47 20 15 48
4 11 20 6 4 10 4 10 14 1 5 10
41 22 72 112 101
19 15 41
25 19 47 134 5 5 10
13 13 27
325 i45 022 203
101 000 00 0 00 0
00 0 00 0 00 0 10 1
SL 082082
TABLE 20 (cont'd)
number of female rats FOR WHICH THE SPECIFIED TISSUE WAS EXAMINED MICROSCOPICALLY (Rats Maintained for 24 Months on Water Containing Vinyiidene Chloride)
Number of rots autopsied luring irur time period indlooted "'ore 1 i'nb
Ear Canal
Hard Palate
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
Control 50 ppm 100 ppm 200 ppm
1-6 Months
0 0 0 0
0 0 0 0
0 0 0 0
0 0 0 0
7-12 Months
1 0 J 0
0 0 0 0
0 0 0 0
0 0 0 0
13-18 Months
15 5 4
13
0 0 0 0
0 0 0 0
0 0 0 0
19-24 Months
41 25 24 20
Terminal Cumulative
Kill
Results
23 80 18 48 17 48 15 48
000 000 0 00 101
000 000 i01 0 00
0 00 000 10i 000
SL 082083
V
TABLE A-l
INDIVIDUAL AND MEAN BOOT WEIGHTS OF MALE RATS MAINTAINED ON DRINKING WATER CONTAINING 0 PPM VINYLIDENE CHLORIDE FOR 731 DATS
Animal _________________________________________________ Days on Teat Number 100 139 181 210 238 266 294 330 357 385 413
74-3066
476
517
542
565
588
594
606
598
614
627
645
3067
434
ND 501 514 530 536 539 552 564 576 593
3068
499
529
557
579
594
6Q5
603
617
607
516
630
3069
434
ND 502 509 529 535 549 550 583 561 564
3070
453
535
568
567
580
604
610
609
612
611
616
3071
460
ND 534 546 551 561 566 556 574 577 589
3072
519
574
605
626
639
654
668
646
627
667
687
3073
524
ND 596 611 624 631 64 5 627 607 653 654
3074
459
515
540
559
561
581
579
556
609
596
626
3075
466
ND 516 517 541 541 548 530 560 569 574
3076
432
468
485
505
519
527
541
543
557
545
563
3077
468
ND 523 535 555 574 580 596 606 b03 625
3078
477
567
589
613
D44
662
659
660
683
673
677
3079
405
ND 469 470 497 512 510 514 534 531 545
3080
407
462
508
522
536
553
559
566
586
588
618
3081
438
ND 519 535 554 569 575 571 574 575 593
3082
475
539
573
573
589
600
588
590
459
3083
475
ND 537 558 568 588 598 579 600 613 626
3084
470
493
503
515
525
526
542
543
548
551
577
3085
450
ND 525 544 564 564 578 577 590 596 618
3086
374
402
429
432
436
449
451
442
635
467
487
3087
530
ND 561 582 592 617 619 609 466 636 659
3088
421
477
508
526
550
562
563
577
587
582
599
Dead
3090
548
573
568
640
651
665
677
676
699
697
715
3091
461
ND 454 501 516 535 541 544 <=------- --Dead--
3092
424
467
484
493
504
511
520
535
533
546
556
3093
401
ND 447 451 466 480 476 480 484 498 517
3094
476
529
545
571
595
603
618
592
617
614
631
3095
508
ND 598 609 632 641 654 636 665 678 701
3097 3098 3099 3100 3101 3102
3103 3104
3105 3106 3107 3108 3109 3110 3111 3112 3113 3114 3115 3116 3117 3118 3119 3120 3121 3122
3123 3124
3125 3126 3127 3128 3129 3130 3131 3132
3133 3134 3133 3472 3474
3476 3478 3480 3482 3484 3486 3488 3490
MEANlSD
493 505 479 450
436 475 432 425
529 529 437 478 412 444
430 481 506 589 486 465
501 453 539 492 440 527 505 413 467 498 469 477 525 436 425 434 507 479 453 423 494 466 450 519 522 465 459 407 419
468+41
ND 535
ND 503
ND
547 ND
448 ND ND ND ND
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND
511+44
562 591 533 556
513 602
507 465 605 598 503 528 482 506 524 550 633 654 568 556 551 522 612 584 499 593 571 491 577 560 524 544 594 488 490 528 564 584 549 518 601 588 520 587 572 512 506
431 534
540+46
569 601 543
543 537 626
518 482
627 ND ND ND ND ND ND ND ND
ND ND ND
ND ND ND ND ND
ND ND ND ND
ND ND
ND ND ND ND ND ND ND ND 530 620 594 524
623 591 529 526 433 546
54851
583 618 553 563
546 657 528
487 653 616 527 547 515 505 566 549 676 657 602 595 591 556 646 592 526 61Q 607 492 625 583 554 574 629 512 521
541 606 612 603 533 638 614 547 648 606 548 534 427 554
569+52
611 627 563 586
553 660 531 493 675
ND ND ND ND ND ND ND ND ND ND ND
ND ND ND ND ND
ND ND ND ND
ND ND
ND ND ND ND ND ND ND ND 548 659 638
568 654 625 569 540 442
582
577t57
607 633 566 590 554
673 540 489 659 641 545 535 580
543 560
597 695
693 636 625
605 604 673 647 545 646
649 528 656 615 577 594 648 526 540 580 627 657 633 557 676 637 567 680 628 569 545
423 571
592iS7
610 631 565 593
568 687 541
505 677 639 556 584
548 551 586 592 695 668 632 626
609 620
679 665 544 650 642 525 670
611 574
593 632 525 523 587 623 656 641 569 684 635 578 699 640 582 547 391 590
592;58
629 640 577 610
578 706 562 505
673 636 544 596 562 551 535 603 726 686 652 629
607 639 681 663 555 668 672 549 692 617 574 611 653 547 550 590 623 676 665 581 707 640 589 705 643 587 558 397 613
6Q4t61
632 631 579 622 588 710 555 525 693 615 489 603 565 565 578 629
733 670 646 631 597 629 673 670 562 665 ,672 552 707 619 564 608 655 541 553 612 626 675 666
583 715 611 564 697 643 582 560 371 606
607t6l
643 653 602
637 604 739 578 525 704
579 337 623 585 579 594
643
733 667 647 633 608 654
687 690 572 679 672 569 728 637 563 618 655 549 573
624 638 671 689
593 743
510 520 723 659 595 561 357 627
615+72
^Reports ware already done for the firac 97 days. ND - No data was available on these rata.
SL 082084
TABLE A-l (coht'd)
INDIVIDUAL AND MEAN BODY WEIGHTS OF MALE RATS MAINTAINED ON DRINKING WATER CONTAINING 0 PPM VINYLIDENE CHLORIDE FOR 731 DAYS
Animal Number
469
Days on Teat 568 596
652 687
3066
639
666
661
674
669
670
685
707
694
675
651
646
3067
583
609
611
615
614
599
626
625
637
600
560
562
3068
636
640
633
628
602
580
<----
---------- Dead--------
--3069
571
578
576
577
586
581
582
3070
602
602
592
595
576
481
599 573 ---------- Dead----- -
3071
577
585
586
590
565
563
554 <--`
3072
689
690
687
690
642
--
-Dead----------- ---
3073
653
*59
653
657
585
605
3075 3076 3077 3078 3079 3080 3081 3082
3083 3084
3085 3086 3087 3088 3089 3090 3091 3092
3093 3094 3095 3096 3097 3098 3099
3100 3101 3102
3103 3104 3105 3106 3107 3108 3109 3110
3111 3112 3113 3114 3115 3116 3117 3118
3119 3120
3121 3122
3123 3124 3125 3126 3127 3128 3129 3130 3131 3132
3133 3134
3135 3472 3474
3476 3478 3480 3482 3484 3486 3488 3490
584 584 564 578 633 651 680 698 536 561 614 633 594 605
643 640 572 564 620 626 479 489 649 651 584 597
719 <----564 514 621 694 ^-----------
607 648 614 644 611 741 577 529 690
545 526 611 702
633 648 617 651 605 748 573 541 710
633 575 577 562 605 699 665 647 649 602 669 686 707
581 692
673 573 754 650
506 620 656 556 573 640 626 677 709
603 748 596 593 715 657 584 570 ^-----634
ND ND ND
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND
ND ND ND ND ND ND ND ND 606 760 500 542 700 665 591 577
640
624+58 619:62
573 568 651 705 553 636 601
823 567 622 483 643 592
542 527 603 702
623 656 610 644 601 749 568 517 682
631 603 594
638 737
-670 642 597 670 669 707 589 685
688 574 750 668
635 653 564 571 632 631 667 727 606 755 470 551 663 860 583 570
610
625:61
539 575 657 700 560 629 600
624 582 629 493 636 601
699
540 520 574 699
616 6S7 617 652 611 748 571 544 709
632 609 611
654 750
669 639 595 684 678 689 590 684 691 582 728 658
643 650 559 587 655 630 658 753 6Q6 757 <--
686 :93
o3
648
633:58
538 585 658 685 552 638 597
577 644 493 599 586
535 496 674
634 615 647 603 734 568 545 687
ND ND ND
ND ND
ND ND 4rND ND 683 586 668 686 578 757 631
632 636 556 586 631 583 638 761 599 733
681 571 560
609
61860
559 562 654 659 550 639 582
599 637 488 537 560
610 623 623 562 729 575 544 672
617 606 624
610 666
611 562
70-9-
677 568 672 691 573 833 595
602 555 575 666 609 621 807 615 649
681 560 571
625 615+65
533 559
570 <-----
660 645 648 597 --D
672 623 551 ^----------- Dead-'
572 565 577 543 535
527
655 656 653 60S 568
567
570 566
----------Dead----------
597 --Dead639 630 622 594 594 617
496 497 521 522 586 640
404 -Dead-- 568 485
623 "Dead-
632
625 609 595 547
--Dead-
615 630 639 611 566 IDead 637 632 659 607 597 596
--Dead
607 *------
660 549
Dead----
549
706 696
692
596 668 691 597 876 609 -Dead-
692 589 644 691 606
596
669 -Dead-
693 600
532 673 628
667 564
586 --Dead--
<. Dead--
652 636
518 Dead
-Dead--------------- >
-Dead564
552
624 466 <:------- ------- ----Dead
580 567 582 556 559 :
591 579 582 527 =----- Dead-
669 678 691 620 604
604 540
499 <-----
903
617 561 598 566 554 520
713 651 668 600 513 420
--Dead--
-Dead-
-Dead-
662 681
669 <--Dead-
583 548
---------- Dead--------------
564 566
560 --Dead621+81 610:59 617157 58654 56644 563:58
ND No data was available on these rats.
SL 082085
TABLE A-l (cont'd)
INDIVIDUAL AND MEAN BODY WEIGHTS3 OF MALE RATS MAINTAINED ON DRINKING WATER CONTAINING 50 PPM VINYLIDENE CHLORIDE FOR 731 DAYS
Animal _____________________________________________Days on Test Number 100 139 181 210 238 266 294 330 357 385 413
74-3212 3213 3214 3215 3216 3217 3218 3219 3220 3221 3222 3223 3224 3225 3226 3227 3228 3229 3230 3231 3232 3233 3234 3235 3236 3237 3238 3239 3240 3241 3242 3243 3244 3245 3246 3247 3248 3249 3532 3534 3536 3538 3540 3542 3544 3546 3548 3550
MEANlSD
493 503 463 396 446 469 546 556 453 432 507 429 500 462 469 437 438 524 463 384 461 462 450 433 432 436 453 471 507 501 539 480 410 455 514 432 460 465 476 516 491 498 475 438 426 426 533 469
46839
526 ND
495 ND
502 ND
608 ND
551 ND
548 ND
546 ND
523 ND
481 ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND
520 ND
511 ND
498 ND
460 ND
589 ND
526+40
537 552 503 460 502 562 621 630 572 550 564 511 580 536 544 491 511 618 555 440 514 548 492 477 499 485 518 580 577 589 609 533 492 499 599 502 557 528 544 569 563 563 521 478 490 502
63 8 515
537+45
554 559 516 472 515 554 643 648 585 568 564 516 584 563 558 505 525 637
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND 563 582 558 574 520 480 495 522
635 534
55547
568 575 531 480 530 568 665 656 583 574 526 579 611 585 572 537 534 655 573 459 537 570 524 498 508 516 534 608 612 626 628 548 510 520 590 522 546 545 573 600 572 598 526 523 499 543 645 542
56147
578 587 541 492 543 591 685 663 582 581 594 537 629 597 584 522 532 662 ND ND
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND 585 607 562 605 535 523 523 541
659 544
57849
585 588 549 500 548 594 683 668 587 580 586 552 629 607 593 531 546 671 595 464 563 582 537 505 549 531 557 634 635 638 645 563 522 537 628 531 602 553 611 616 583 626 545 541 536 557
667 551
579+49
596 616 517 468 563 618 701 673 557 595 598 562 645 615 616 559 560 698 573 477 571 591 556 519 571 546 570 637 632 649 635 578 562 554 634 556 607 551 625 614 589 644 553 550 516 541
677 551
587+51
586 590 598 611 615 646 583 592 592 524 531 550 568 570 602 609 605 632 717 706 706 688 682 697
567 488 Dead 616 600 617 602 603 622 563 569 598 637 640 649
----Dead---------------- > 629 605 641
567 570 587 567 566 588 700 661 690 594 589 546 483 483 496 576 571 587 608 611 621 542 552 570 517 517 529 577 574 587 556 572 573
572 575 583 668 672 665 656 660 688 658 657 680 633 609 596 583 580 602 556 557 571 563 558 564 618 593 530 558 562 560 613 621 626 566 563 564 625 628 649 627 605 652 575 586 590
637 634 648 548 555 572 555 554 568 543 532 549 570 --- :Dead------- ^ 671 675 707 560 565 580
594+49 591+48 606+50
aReports were already done for the first 97 days. ND = No data was available on these rats.
SL 082086
TABLE A-l (cont'd)
INDIVIDUAL AND MEAN BODY WEIGHTS OF MALE RATS MAINTAINED ON DRINKING WATER CONTAINING 50 PPM VINYLIDENE CHLORIDE FOR 731 DAYS
Animal Days on Test Number 441 469 472 497 533 568 596___624 652 687 715 729
3212 3213 3214 3215 3216 3217 3218 3214 3220 3221 3222 3223 3224 3225 3226 3227 3228 3229 3230 3231 3232 3233 3234 3235 3236 3237 3238 3239 3240 3241 3242 3243 3244 3245 3246 3247 3248 3249 35 32 3534 3536 3538 3540 3542 3544 3546 3548 3550
MEAN+SD
636 609 615 357 599 632 98 3 667
615 599 602 645
656 594 593 694
499 592 630 567 532 590 589 612 683 695 686
600 566 564
559 628 564
--
642 591 656 574 573 512
693 569
611+48
619 633 604 371 597 628
670
633 373 621 659
662 596 591 696
ND ND ND ND ND ND ND ND ND ND ND
ND ND ND
ND ND ND
650 592 649 561 574 536
703 579
61744
610 640 611 573 593 6 29
674
631 576 617 654
655 588 594 695
495 596 630 569 536 588 590 614 655 675 679
591 568 573
572 524 528
46 j35 655 576 573 536
705 502
60251
602 602 626 624 623 623 579 587 596 576 630 617
618
632 623 565 629 625 654 634
658 659 593 596 597 519 707 695
493 486 604 589 636 618 562 544
589 586 598 587 652 707 662 642 664 655 687 657
549 546 564 577
576 575 397 547
651 612 588 576 635 613 572 584 559 568 538 533
694 684 566 573
602* 58 60249
601 607 611 604 603 623 589 605 552 459 624 625
-----Dead
-Dead649 694
627 592 615 495
-Dead613 620 595 608
-TT-----
643 -Dead-
409 583 588 612 610 493 -------
549 563 574 591 903 -6-----621 598 645 633 ^--
-Dead-
520 519 575 581 ------- Dead------575 587
-Dead594 596 535 520 532 588 580 519 383 433 ++-----
-Dead663 659 561 559
602 617 593 616 634
605 603 566
Dead
635 712
-Dead-
598 606 560
Dead----
-Dead-
610 620 578
-Dead-
-Dead-
748 -Dead-
-Dead-
-Dead-Dead-
609 573
-Dead-
594 596 595 581 583
-Dead-
-Dead-
-------------Dead577 580 :557 596 572 *5--
------------ Dead-Dead-
556 558 511 591 584 561
--------- Dead--------Dead-Dead--
-Dead-
524 -Dead-
399 524
524
Dead 534
-Dead415 546
-Dead-Dead-
589 601 571 547 524 --------- Dead-------
-Dead-
563 -Dead-
524 498
-Dead-
-Dead-
585 577 529
-Dead-
-Dead-
-Dead-
645 557 562 555
-Dead-Dead--
588r82 581t63 588161 588145 562126 51483 560+48
* Significantly different from control mean by Dunnett's test, p<0.05. ND = No data was available on these rats.
SL 082087
TABLE A-l (cont'd)
INDIVIDUAL AND MEAN BODY WEIGHTS3 OF MALE RATS MAINTAINED ON DRINKING WATER CONTAINING 100 PPM VINYLIDENE CHLORIDE FOR 731 DAYS
Animal
Days on Test
Number 100 139 181 210 238 266 294 330 357 385 413
74-3174 3175 3176 3177 3178 3179 3180 3181 3182 3183 3184 3185 3186 3187 3188 3189 3190 3191 3192 3193 3194 3195 3196 3197 3198 3199 3200 3201 3202 3203 3204 3205 3206 3207 3208 3209 3210 3211 3512 3514 3516 3518 3520 3522 3524 3526 3528 3530
MEANiSD
514 515 560 528 509 439 485 508 515 485 554 560 408 460 477 568 456 471 427 458 520 477 477 422 556 428 397 446 493 567 533 441 379 470 495 446 469 458 481 476 450 457 581 387 427 446 531 413
480+51
561 ND
606
ND 569
ND 551
ND 571
ND
628 ND
448 ND
524 ND
517 ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND
504 ND
472 ND
617 ^-------454
ND 586
ND
593 594 635 602 594 508 557 601 586 551 652 627 474 554 521 633 536 537 501 535 564 532
558 500 631 489 480 505 560 673 587 486 452 570 556 544 524
503 518 527 486 511 650
466 469 610 445
543+59 549+58
612 610 649 614 607 515 567 609 609 578 576 617 485 530 529 637 557 551
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND 535 539 505 519 667
484 481 630 463
566+57
620 638 664 622 618 537 577 615 624 589 534 640 494 536 534 663 567 566 513 556
ND
553 ND
532 644 501 508 526 575 697 594 525 482 595 576 574 538 536 551 549 521 539 693
496 490 641 472
56958
635 654 679 640 627 548 592 636 637 607 548 648 516 539 544 666 590 566
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND
ND 571 567 537 561 704
510 499 669 479
592+61
644 664 677 660 631 558 60 0 640 649 607 617 669 525 576 557 667 593 580 542 587 592 585
603 539 666 538 528 529 604 721 624 548 517 617 632 598 470
566 578 575 564 559 709
518 509 679 500
59458
641 654 685 663 634 577 601 647 662 609 587 647 552 587 552 640 569 571 563 585 609 593 618 539 685 558 548 548 641 739 634 515 541 633 654 629 4_--------
590 605 588 578 581 710
521 526 =-------516
645 644 649 P84 695 689 703 687 696 662 649 662 636 626 . 621
579 586 592 619 603 626 654 639 646 669 662 671 609 600 599
536 579 457 676 662 675 558 558 585 604 603 620
558 538 573 634 603 Dead 588 576 531 596 584 582 565 559 558 596 594 599 606 610 623 604 608 629 6Q3 599 600 549 546 554 692 676 642 562 578 529 546 541 565 554 547 568 643 650 669 746 728 741 635 634 637 504 573 586 547 548 563 622 606 605 663 661 665 623 632 646
Dead----------.............. > 595 599 609 620 619 625 590 587 597 589 587 591 578 582 588 705 713 733
_________ >
525 516 521 544 549 564
Dead------------------------ -> 519 532 544
603+53 607+55 60650 610+56
aReports were already done for the first 97 days. ND " No data was available on these rats.
SL 082088
TABLE A-l (cont'd)
INDIVIDUAL AND MEAN BODY WEIGHTS OF MALE RATS MAINTAINED ON DRINKING WATER CONTAINING 100 PPM VINYLIDENE CHLORIDE FOR 731 DAYS
Anireal
Days on Test
Nnreber 441 469 472 497 533 568 596 624 652 687 715 729
3174 3175 3176 3177 3178 31'9 31S 0 3181 3182 3183 3184 3185 3186 3187 3188 1189 3190 3 L91 3192 3193 3194 3195 3196 3197 3198 3199 3200 3201 3202 3203 3204 3205 1206 3207 3 208 3209 1210 3211 1512 3514 3516 3518 3520 3522 1524 3526 3528 3530
MEAN!SO
621 702 684 6 48 618 59 7
635 680 582 522 679 581 612 566
575 622 557 614 626 629 576 549 673 581 572 567 680 764 643 590 566 556 671 657
606 634 606 555 594 726
512 558 +7-----551
612155
645 697 b31 o05 6L4 611
625 b80 598 510 663 590 618 568
568 627
nd
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND
ND 633 597 571 607 717
516 569
553
609+51
621 700 671 634 597 613
626 679 586 501 662 587 609 563
542 624 545 612 615 647 564 489 669 582 574 569 690 748 630 596 534 358 666 665
605 633 601 576 606 712
508 567
565
60368
*4--------706 663 64 3
617
616 697 585 527 650 598 617 575
536 630 542 623 587 658 428 436 683 595 584 581 688 751 591 602 568 -6----664 665
598 633 606 592 611 708
510 572
574
-Dead696 705 734 726 752 728 683 Dead
628 617 550
-Dead-
611 593 571 450
-Dead--
-Dead-
598 597 600 559
-Dead-
*6---- 640 462
------Dead--------
635 ^--------
-------------- Dead--------^-----------------------------------------D] ead-
Dead-
>
504 625 595
+=;--------433 580
---- ------Dead<---------------------------------------- D] ead-
594 577 590 539
332
-V Dead
594 584 598 578 576 544 371 419
540 532 408
-------- -Dead-
-Dead-
-Dead-
611 607 605 586 562 499
-Dead-
529 601
504 595
+7-- 598
589
----------De ad---------
530
--
-Dead--
516
^--
-Dead-----------------
660 651 656 656 672 655 640 654
"6----------- --
-------- Dead-----
-Dead-
641 632 608 534
-Dead-
579 529 515 438 526 473 472 416
576 ----
-Dead-
530 547 545 541 414
-Dead-
686 708 704 714 689 689 671 686
724 636
-Dead-
-Dead-
576 587 600 564
--Dead-
558 546 555 535 499
-Dead-
-Dead-
647 664
630 677
628 694
601 612 564 516 513 677 693 666 638 654
---------- Dead--------
575 558 51b
-Dead-
591 630 633 621 621 589 517 570
635 552 584 579 550 500
- Dead------- 3+
588 604 593
610
566 ^--------
608 647
626 ^7--
642 -Dead--
^-------Dead-
--Dead----------------''
>
-Dead-
-Dead-
547
528
509
-Dead-
---------- Dead--------
559 559 563 569 566 523 512 495
608i65 596r56 591+60 593169 586+73 60084 581+84 5351123 551+107
ND = No data was available on these rats.
SL 082089
TABLE A-l (cont'd)
INDIVIDUAL AND MEAN BODY WEIGHTS3 OF MALE RATS MAINTAINED ON DRINKING WATER CONTAINING 200 PPM VINYLIDENE CHLORIDE FOR 731 DAYS
Animal
Days on Test
Number 100 139 181 210 238 266 294 330 357 385 413
74-3136 3137 3138 3139 3140 3141 3142 3143 3144 3145 3146 3147 3148 3149 3150 3151 3152 3153 3154 3155 3156 3157 3158 3159 3160 3161 3162 3163 3164 3165 3166 3167 3168 3169 3170 3171 3172 3173 3492 3494 3496 3498 3500 3504 3506 3508 3510
MEANlSD
489 370 526 461 438 450 484 470 486 502 517 382 487 487 516 488 483 512 482 459 584 466 518 504 557 502 428 497 467 420 491 478 466 502 491 397 527 467 416 533 469 515 474 501 480 472 416
47942
524 ND
571 ND
498 ND
558 ND
549 ND
591 ND
517 ND
559 ND
563 ND ND ND ND ND ND
ND ND
ND ND ND ND ND ND ND ND
---- -- ND ND ND ND 564 ND
495 ND
494 ND
489 ND
432
537 423 576 512 498 516 577 544 571 567 615 446 538 535 568 561 574 610 531 562 637 569 619 567 641 546 487 594 567 500 569 559 575
611 488 628 550 469 599 525 583 511 531 501 527 449
52944 54951
551 439 603 529 518 529 597 549 591 561 631 462 551 549 588 566 591 639
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND
ND ND ND ND 604 480 525 602 519 561 510 537 464
550+51
558 455 616 541
531 541 612 557
-------583 650 479 564 565
595 592
614 542
ND 593 655 614 606
588 651 577 530
641 570 524 581 596
577
571 469 619 553 543 553 622 576
594 667 489 568 580 586 611 617 660
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND
644 520 626 512 627 486 547 608 529 585 515 566 479
57451
ND ND ND ND 639 494 567 619 545 591 524 581 496
574+52
584 477 633 562 543 566 634 579
595 666 494 584 587 586 616 626 646 558 616 691 630 656 616 725 418 575 681 624 541 600 621 640
705 536 690 599 497 641 582 630 542 620 536 590 498
596163
593 ND 587 536 492 ND 480 508 633 ND 647 666 554 ND 559 582 551 ND 548 560 580 ND 591 599 631 ND 650 654 578 ND 586 591
585 ND 574 597
677 684 676 694
508 509 506 529
593 603 608 620
581 589 588 588
567 537
----- Dead------- >
625 627 631 634
631 659 638 663
652 668 665 693
566 582 582 587
619 631 635 651
670 682 674 698
<------------------Dead---- ----
658 656 638 640
622 625 636 651
728 732 741 754 ^-------- ------------Dead--------------------- 5,
571 597 585 b08
669 699 678 701
631 650 659 666
543 555 558 565
596 588 557 547
629 645 645 650
649 659 648 657 _______ ^
717 739 732 748
545 571 566 580
693 726 720 743
596 619 626 626
496 524 521 523
557 655 648 658
605 603 605 627
610 645 649 647
578 558 554 570
628 638 632 622
559 556 570 586
617 611 609 623
495 510 ND
516
602156 622161 61558 624161
Reports were already done for che first 97 days. ND * No data was available on these rats.
SL 082090
TABLE A-l (cont'd)
INDIVIDUAL AND MEAN BODY HEIGHTS OF MALE RATS MAINTAINED ON DRINKING WATER CONTAINING 200 FFM VINYLIDENE CHLORIDE FOR 731 DAYS
Animal Number
Days on Test
441
469
472
497
533
568
596
624
________________________________
652
687
715
729
3136 3137 3138 3139 3140 31 '+1 3142 3143 3144 3145 3146 3147 3148 3149 3150 3151 3152 3153 3154 3155 3156 3157 3158 3159 3160 3161 3162 3163 3164 3165 316b 3167 3168 3169 3170 3171 3172 3173 3492 3494 3496 3498 3500 3504 3506 3508 3510
MEANtSD
513 519 671 576 562 o!5 646 587
582 670 529 625 572
632 666 680 584 660 693 <----626 650 726 <-----597 680 677 571 513 659 640
---
736 580 733 617 542 649 628 646 579 534 577 619 507
616+61
^---
527 687 585 564 621 655 596
520 683 577 558 621 64 5 592
+?--------679 529 644 575
671 525 648 578
638 669 683
ND ND ND
634 662 677 590 666 686
ND 527 ND 646 ND 727
ND 610 ND 679 ND 684 ND 570
ND 403 ND 654 ND 624
ND ND ND ND 546
643 634 654 574
730 592 736 616 539 641 625 649 568
633 512
612+55
624 508
61869
526 682 582 575 626 646 595
526 681 575 575 624 627 561
653 531 654 570
644 637 692 603 672 686
+4---. 649 739
604 671 681 573
673 611
732 591 729 621 543 622 644 650 571
604 523 646 553
626 628 645 605 653 655
625 686
ND ND ND ND
639 542
726 600 711 587 529
635 630 585
625 511
62857
598 484
609+56
----- Dead-
538 657 565 548 631 612 553
541 651 503 549 632 595 470
528 556 523 512 Dead
641 584
---- -Dead-
<r--
--Dead-
549 543 520 511 489
604
616
592
548
564
582 565 <-------- -Dead-
<-----
--Dead-
-Dead-
----- Dead--
<--------513 652 537
526 669 518
513 679 410
--Dead508 665 -S-------
496
461
673
684
-----Dead--------
468 717
Dead-
61b
619
63? 654
599 618
575 <------ -
-Dead-Dead-
-Dead-
61
616
613
610
592
422
568
64 642 592 <-- --'----Dead--------
aad-
-Dead-
-Dead-
-Dead-
535
<-
-Dead-
---------- Dead--
577 585 576 544
-Dead--
613 656
480 634
61-----
-Dead-Dead-
560 563 537 503 460
-Dead-
631
623
-Dead588
557
-Dead-
336
-Dead-
---------- Dead---- 725 729 595 607
701 593
700 611
643 581
583 542
595 554
678
695
660
544
-Dead-
556
412
-Dead--
521 535 491
-Dead-
-Dead-
648 629 586
657 646 602
655 654 588
668 668 581
645 719 563
614 666 550
615 Dead 523
-Dead-
-Dead479 381
-Dead-Dead-
-45-
588+73 583+83 590+67 589r57 584+77 554+80 566+74
ND = No data was available on these rats.
SL 082091
TABLE A-2
INDIVIDUAL AND MEAN BODY WEIGHTS OF FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING 0 PPM VINYLIDENE CHLORIDE TOR 730 DAYS
Animal _______________________________ _________________Days on last Number 100 139 181 210 238 266 294 330 357 385 413
74-3250
309
358
349
366
377
394
395
414
423
426
4o5
3251
318
ND 355 354 354 352 350 350 353 54+ 352
3252
286
311
31+
321 330 329
336
3+i
347
34J
356
3253
3 36
ND 371 370 378 386 399 *01 431 + 19 449
3254
299
327
327
338
349
372
365
383
332
373
385
3255
277
ND 288 298 296 313 302 309 306 30b 332
3250
315
335
352
J2ft
349
J 51
3 <* 2
346
347
334
325
3257
319
ND 363 347 384 383 393 3 93 416 382 J92
3258
320
339
255
363 363
374
384
397 415 4 21
445
3259
328
ND 385 396 401 4 lo 417 441 U4 + 31 Dead
3260
348
373
391
394
405
395
413 412
411 + 05
430
3261
294
ND 326 333 333 354 354 365 371 369 382
3262
290
315
326
317
322
325
328
332
335
358
362
3264 3265 3266 3267 3268 3269 3270 3271 3272 3273 3274 3275 3276 327 7 3278 3279 3230 3281 3282 3283 3284
3285 3286 3287 3288 3289 3290 3291 3292 3293 3294
3295 3296 3297 3298 3299 3300 3301 3302 3303 3304 3305 3306 3307 3308 3309 3310 3311 3312
3313 3314 3315 3316 3317 3318 3319 3552 3554 3556 3558 3560 3562 3564 3566 3568 3570
289 300 266 274 301 283 317 2 92 288 272 296
289 281 292 310 283 274 269 305 303 291 274 310 307 309 319 263 273 318 303 307 280 271 276 316 280 276 278 326 292 316 271 287 300 296 273 300 269 333 326 329 280 296 288 269 325 307 301 255 298 309 287 347 303 264 256
MEAN+SD 296*21
314 ND
293 ND
330 ND
333 ND
319 ND
308 ND
309 ND
315 ND
284
ND 318
ND 323
ND 324
ND 317
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND 327 ND 284 ND 332 ND 366 ND 290 ND
322+23
322
339 287 307 328 313 342 312 325 318 323 320 314 334 335 3U 29Q 289 328 333 338 304 335 315 347 341 303 312 347 333 356 320 298 300 348 327 312 319 349 311 332 314 301 314 334 286 323 297 349 346 361 325 341 327 299 369 345 337 286 356 342 315 398 341 300 283
32926
332 343 293 311 337 315 349 320 329 325 325 334 320 331 339 310 300 297 335 347 344 310 358 32a 336 335
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND 347 340 294 359 346 330 383 350 308 286
334+25
340 351 301 330 350 325 367 327 332 342 334
329 323 339 354 316 298 299 331 344 354 321 339 319 328 341 354 366 297 366 354 347 396 374 312
293 ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND
341+27
3+0 3o5 304 330 36 + 323 367 348 346 339 339 353 333 351 354 335 309 314 341 348 384 324 365 344 354 361
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND 368 359 303 384 369 363 400 397 317 297
35228
367 365 301 320 362 329 379 345 344 345 341 365 333 320 360 331 298 309 335 349 363 328 383 382 3S3 360 318 327 355 364
362 329 310 335 375
358 334 341 372 328 356 324 334 360 347 314 357 318 389 366 393 341 347 365 320 394 385 376 306 393 343 344 408 381 317 300
351s29
390 378 303 321 384 333 362 371 34b 353 370 360 340 378 369 344 304 321 344 350 364 332 331 294 358 374 322 327 354 350 381 344 315 339 354 351 334 342 381 337 363 320 332 362 341 330 386 322 404 365 407 352 379 351 319 394 375 395 306 410 383 366 428 386 319 310
357 m3 2
408 374 309 333 390 338 385 382 341 349 368 365 342 381 368 358 307 323 342 349 359 339 365 342 3bb 365 330 317 346 340 351 328 326 337 386 360 330 349 393 333 363 311 328 354 341 319 396 313 396 364 407 341 397 368 320 393 375 385 303 409 363 358 415 397 318 306
356+47
395 377 315 340 386 340 432 388 361 356 376 377 347 394 367 352 298 333 335 348 360 345 381 334 383 375 324 320 357 344 364 334 326 339 380 380 342 360 393 331 360 306 303 327 338 316 425 315 400 367 418 352 400 359 316 380 387 395 306 436 362 367 428 414 320 311
362+36
Dead 389 335 358 423 347 517 390 371 387 394 395 357 399 385 367 314 359 353 345 365 364 372 357 393 397 356 316 375 353 381 348 338 344 395 381 345 383 413 340 379 318 313 347 306 295 473 323 419 391 420 368 398 363 302 350 385 422 312 441 380 379 446 443 333 319
374s43
eporta were already done for Che first 97 days. No data available on chase rats.
r
SL 082092
TABLE A-2 (ceot'd)
INDIVIDUAL AND MEAN BODY WEIGHTS* OF FEMALE BATS MAINTAINED N DRINKING WATER CONTAINING 0 PPM VINYLIDENE CHLORIDE FOR 730 DAYS
Anlaml
Days on Teat
Number
441
469
472 497
533
568
596
624 652 687
715 729
74-3250 486 531 519 563 589 398 944
3251 353 356 349 346 333 295
3252 358 371 367 368
3253 459 46J 447 456 439 *23 428
3254 413 411 411 4Q9 374
3255 324 327 323 326 319 325 307
3256
390
376
359
3257 433 449 458 487 535
3258 455 471 469 476 468 309 538
<--
--"--Dead-
378
Dead
----- -----
330 337 321 314
__Tmrl
585 660 690
-t Dead -->4
3260 3261 3262 3263 3264 3265 3266 3267 3268 3269 3270 3271 3272 3273 3274 3275 3276 3277 3278 3279 3290 3281 3282 3283 3284 3285 3286 3287 3288 3289 3290 3291 3292 3293 3294 3295 3296 3297 3298 3299 3300
424 385 377 < 4-------
381 322 356 423 356 <------
413 369 397 385 395 364 419 387 356 303 364
349 365 329 343 374 349 409 424 <-----326 369 359 380 367 336 341
396 403 344
433 387 372
407 259 355 432 360
420 360 383 400 418 373 427 406 368 316 390 344 364 362 370 389 341 404 402
ND ND ND ND ND ND ND ND ND ND
3302 3303 3304 3305 3306 3307 3308 3309
3311 3312 3313 3314 3315 3316 3317 3318
432 341 379 313 332 373 345 346 508 314 442 365 415 368 402 367 302
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND
3552 3554 3556 3558 3560 3562 3564 3566 3568 3570
393 440 314 438 382 382 451 444 333 325
MEANtSD 379144
395 444 325 472 400 390 473 446 345 323
391+50
429 425 4 28 428 385 390 392 400 369 371 376 385
394 4-----355 426 351
421
382 405 397 422 365 412 397 356 306 391 343 357 354 369 383 335 410 408
<4------
361
349
434 380 411 383 411 379 425 406 359 308 413 344 363 362 374 376 349 400 414
363 595 349
446 399 417 390 405 274 317
264 204 307 302 361 348 378 404 335 428 450
360 s
401
459 391 426 389 429 385 430
398 312 434 349 362 351 396 425 325 448 487
329 332 336 345
379 370 432 506
373 448
<
383 391 403 420
357 360 365 362
339 349 349 357
349 352 359 370
418 418 383 459
422 418 358 408
341 347 296 359 TM
444 448 404 4 96 354 350 323 483 381 369 326 383 311 313 270 317 331 334 290 336
373 376 339 376 338 325 225 s 342 346 309 361 578 <.____ 311 318 274 316 450 462 445 545
355 365 309 368
427 427 320 4 58
362 376 270 386
424 437 368 587
387 386 288 404 322 326 207 322
389 446 318 457 401 381 464 441 341 322
386+50
ND 444 321 462 411 385 484 459 340 314
393+62
397 449 318 464 446 389 534 483 346 315
370+80
413 466 327 476 504 393 495 629 344 315
410+73
*24 424 444 467 476 404 418 432 434 452 47 1 385 383 399 437 4 Dead'TM
---------- ^
r.. . i
----------- >
> 390 375 385 368 383 402
418 455 441 ^-------
470 462 456 375 332
390 403 402 394 405
435 452 474 454 465 483
405 411 432 423 400 420
419 <-----
----- Dead
349 357 4------- Dead
506 4-----
------ Dead-
r 1
418 431 456 429 432 448
314 319 341 324 322
ND
428 423 395 <------
____ \
364 364 373 399 446
382 398 410 410 408 414
347 334 340 335 4--------Dead------ ^ 399 321 s'
462 452 351 *--------
>
348
477 486 469 511
532 596
Dead -
Dead --i
----------
363 357 376 365 334
704
--Dead--
---------- ^
----------> 441 461 504 521 526 576 380 385 400 427 373 513
357 365 386 410 431 431 383 394 418 442 488 498 484 471 492 507 497 513 402 387 392 386 333 273 369 354 366 360 229 401
507 <-----372 317 357 409
369
616 4------- --Deed--
---->
---- Dead-
378 331 355 329 310
320 281 <------- --Dead--->
350 352 345
4--
-- Dead--
--Dead--
336 339
--------- > ---------->
384 399 435
Dead--^
328 537 370 489 386 730 418 285
429 514 334 5 25 546 412 775 572 320 293
426+94
324 621 392 518 391 -- 414 327
454 ------
356 536 <=-- 441 4.___ 652 357 270
417+86
322 319 310
312
632 4_____
--------- >
430 474 668
649 <=---------Dead-
415 403 409 429
Dead
--------- ^
428 413 406 404
364 335
-------------------------T517 622
-- Dead--
--------- ^
4------- -- Dead-- <---- Dead--
> --------- V*
-- Dead--
4----Dead*-
---------
-- Dead--
->
<------Dead--
-------- >
373 344 326 332
<-- Dead -
--------- >
421+83 419:82 40188 412+79
ND No data available on theaa rats.
SL 082093
TABLE A-2 (cont'd)
INDIVIDUAL AND MEAN BODY WEIGHTS3 OF FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING 50 PPM VINYLIDENE CHLORIDE FOR 730 DAYS
Animal Number
________________________________________________________ Days on Test
100
139
181
210
238
266
294
330
357
385
413
74-3398 3399 3400 3401 3402 3403 3404 3405 3406 3407 3408 3409 3410 3411 3412 3413 3414 3415 3416 3417 3418 3419 3420 3421 3422 3423 3424
' 3425 3426 3427 3428 3429 3430 3431 3432 3433 3434 3435 3612 3614 3616 3618 3620 3622 3624 3626 3628 3630
312 286 291 318 271 292 275 314 289 285 297 261 289 302 316 285 291 303 287 287 304 269 297 294 253 297 269 304 274 304 285 290 300 309 309 274 273 273 286 293 292 299 340 290 252 289 310 310
MEANiSD 291117
320 ND
319 ND
282 ND
325 ND
307 ND
305 ND
308 ND
338 ND
303 ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND
319 ND
321 ND
375 ND
283 ND
329 ND
317+23
323 343 322 346 297 322 331 352 325 309 304 265 324 321 329 299 295 321 314 312 330 316 326 342 284 324 306 333 311 328 310 306 319 329 340 315 308 303 325 315 331 322 385 313 296 333 339 343
32019
322 342 331 347 305 324 350 360 322 322 323 283 324 335 353 325 307 335
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND 325 349 333 391 320 344 293 345 360
332+22
314 366 338 356 312 338 348 372 333 320 324 291 336 343 356 334 326 356
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND 352 334 349 345 395 323 294 342 356 353
339+22
331 380 333 365 310 349 349 390 339 328 324 297 364 351 367 343 322 356
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND 352 345 357 350 413 333 309 345 364 357
347+26
329 334 344 368 317 343 366 376 337 328 334 296 357 353 388 359 325 371 352 329 354 320 341 375 298 344 323 355 329 346 334 343 338 334 370 323 328 329 338 357 356 355 427 336 308 355 373 359
346+24
324 372 358 374 321 366 399 374 340 338 341 304 377 356 383 360 329 388 359 335 372 331 343 376 300 346 319 355 337 363 326 354 351 354 391 330 328 330 355 329 367 355 436 347 364 320 372 376
353126
348 393 360 371 313 362 375 392 345 360 334 305 365 365 397 359 327 386 352 328 361 329 335 379 290 339 321 333 335 364 309 350 347 343 385 347 323 331 384 338 362 359 447 428 366 321 382 375
354+30
333 399 364 395 313 363 379 409 340 353 333 301 378 379 389 359 330 381 359 340 371 338 327 374 296 348 316 331 348 349 316 351 344 355 373 348 316 326 376 353 392 378 470 609 316 359 386 374
361148
343 410 388 413 322 369 416 422 349 391 334 307 363 416 424 377 335 423 363 334 376 342 336 398 298 369 319 337 354 377 330 355 356 365 386 350 330 335 379 339 398 384 506 Dead 326 372 391 389
368139
3Reports were already done for the first 97 days. ND " No data was available on these rats.
SL 082094
t
TABLE A-Z (cont'd)
INDIVIDUAL AND MEAN BODY WEIGHTS OF FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING 50 PPM VINYLIDENE CHLORIDE FOR 730 DAYS
Animal
Days on Teat
Number
441
469
472
497
533
568
596
624
652
687
715
729
74-3398 3399 3400 3401 3402 3403 3404 3405 3406 3407 3408 3409 3410 3411 3412 3413 3414 3415 3416 3417 3418 3419 3420 3421 3422 3423 3424 3425 3426 3427 3428 3429 3430 3431 3432 3433 3434 3435 3612 3614 3616 3618 3620 3622 3624 3626 3628 3630
350 399 375 418 330 380 424 439 359 384 344 312 356 434 427 383 330 400 362 348 373 347 335 402 296 377 324 344 354 375 318 352 357 381 397 359 335 345 402 377 392 412 600 *-----377 329 387 386
366 417 383 4 36 344 386 429 435 362 418 351 316 369 524 422 392 341 396
ND ND ND ND ND ND ND ND ND ND ND ND
nd
ND ND ND ND ND ND ND 426 377 423 441 626
337 383 399 400
356 429 380 421 341 376 436 435 357 406 347 312 373 532 423 395 341 402 365 345 384 351 337 404 307 387 325 340 367 369 322 349 362 378 389 361 309 342 408 378 421 420 625
389 341 399 389
362 428 398 438 332 386 452 406 370 423 353 312 383 648 427 404 342 426 366 340 386 346 345 410 309 390 318 340 366 376 327 357 365 385 387 377 320 347 418 389 4------
370 435 407 474 328 431 485 430 373 435 354 328 382
426 435 343 395 357 346 383 342 357 452 310 389 314 335 362 384 330 367 371 396 402 387 321 352 426 405
354 401 395 384
355
383 403 392
379 450 419 484 342 459 534 428 381 431
361 323 389
403 478 411
341 494 545 419 392 461 361 327 386
421 4-----351 396 360 415 398 346 366 <--------313 395 320 339 374 403 340 369 393 406 449 461 332 369 420 418
454
347 383 366 713 399 324 v-----
319 405 311 328 374 392 331 372 391 400 517
334 386 422 475
-Oead-
370
358
416
410
414
409
405
407
448 494
<--------- ----Dead493 331
< -Dead-
428 479 547 ^--Dead--
-Dead-
348 343 343 346 345
582
697
--- -Dead-
604
--Dead-
401 333 <-------------- Dead-
419
423
454 450
478
491
539
583
582
615
487 398 386 391 398
343 354 348 354 353
416 494
----- Dead-
-Dead-
494 540
-Dead-
------------ -Dead-
353 363 350 356 357
389
390
372
368
360
371
367
345
330
Dead
<7-------------------------- -Dead-----------
400
422
417
423
443
111 ---------- Dead------ -
-Dead-
Dead
339 354 373 397 429
407
412
414
408
412
320
332
312 4-------Dead-------- 4
337 344 333 327 324
385 377 367 363 362
406
414
432
475
514
345
350 363
366
377
403
436
508
4--Dead--------
405 420
420 4----------
395 384 Dead-
377
582 <7---------
Dead--
-Dead-
371 388 592 ^------ Dead
404
395
416
422
432
407 401 364 325 279
4---------
----- Dead--
-Dead-
-Dead-
-Dead-
374 448 432 419
379 483 437 429
354 4-----418 474
267
341
--Dead---------------- 4
356
Dead
4----Dead------- ^
MEANtSD 374147 404+61 38155 382t54 383i43 39447 404+76 415+72 419i77 415+79 384+66 40078
ND = No data was available on these rats.
SL 082095
TABLE A-2 (coat'd)
INDIVIDUAL AND MEAN BODY WEIGHTS3 OF FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING 100 PPM VINYLIDENE CHLORIDE FOR 730 DAYS
Animal ^___ Days on Test
Number
100
139
181
210
238
266
294
330
357
385
415
74-3360 3361 3362 3363 3364 3365 3366 3367 3368 3369 3370 3371 3372 3373 3374 3375 3376 3377 3378 3379 3380 3381 3382 3383 3384 3385 3386 3387 3388 3389 3390 3391 3392 3393 3394 3395 3396 3397 3592 3594 3596 3598 3600 3602 3604 3606 3608 3610
282 336 263 316 274 272 319 323 281 294 307 270 285 317 322 293 287 283 275 281 313 272 295 297 272 289 291 267 288 283 279 266 290 290 297 307 286 274 282 300 287 276 256 318 305 307 295 280
308 ND
288 ND
308 ND
334 ND
331 ND
335 ND
313 ND
334 ND
299 ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND
314 ND
306 ND
292 ND
320 ND
318 ND
309 382 290 343 303 309 342 348 331 331 331 302 347 360 351 308 309 322 307 299 346 303 324 320 267 288 305 292 325 323 310 297 316 309 334 355 382 286 316 318 311 311 305 346 339 335 329 313
313 385 284 349 307 303 364
353 332 330 325 298 343 358 359 314
ND 328
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND
^---------319 310 319 301 338 333 365 323 313
313 389 291 360 303 310 380 368 342 338 320 302 365 369 358 311
ND 340
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND
325 332 342 312 363 340 359 339 348
324 408 290 373 315 319 388 379 344 336 328 314 381 385 367 326 351
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND
338 330 348 318 366 350 383 339 363
333 412 298 378 322 312 395 379 359 337 245
313 399 394 368 318 342 367 317 329 377 324 358 334 354 348 354 342 332 342 330 322 356 328 370 376 579 318
340 331 325 318 354 349 378 342 380
339
347
355
426
418
437
307
314
330
375
371
383
319
315
316
326 330 325
399
415
418
374 365 367
356
386
383
325
347
343
-4--------- ---------De ad-----------
314
314
314
342
351
362
427
425
419
384
394
418
322
330
326
347
350
354
402
396
393
313
349
334
337
318
314
388
375
375
327
331
317
352
343
346
337
341
331
342
336
339
360
343
361
369
368
355
342
331
339
331
332
324
342
344
351
326
327
311
314
317
319
366
348
359
350
341
329
360
358
352
372
389
371
<r-- ------------- -Dead-------------
328
327
322
377
m 397 320 334 435 373 399 353
322 Dead 449 436 338 366 405 345 331 382 331 342 333 350 370 371 349 341 355 333 322 372 329 363 396
334
346 339 335 325 364 357 387 350 403
345 340 330 321 377 363 372 347 415
355 345 336 324 372 378 382 344 425
366 351 340 332 397 378 389 350 394
MEAN1SD 29118 314115 321124 329124 339126 349129 351146 352130 353130 354133 364134
aReports were already done for che first 97 days. ND = No data was available on these rats.
SL 082096
4
TABLE A-2 (cont'd)
INDIVIDUAL AND MEAN BODY WEIGHTS OF FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING 100 PPM VINYLIDENE CHLORIDE FOR 730 DAYS
Animal
Days on Test
Number
441
469
472
497
533
568
596
624
652
687
715
729
3360 3 361 3362 3363 3364 3365 3366 3367 3368 3369 3370 3371 3372
3373 3374 3375 3376 3377 3378 3379 3380 3381 3382 3383 3384 3385 3386 3387 3388 3339 3390 3391 3392 3393 3394 3395 3396 3397 3592 3594 3596 3598 3600 3602 3604 3606 3608 3610
416 453 342 386 321 334 432 366 409 341
______
325
422 458 360 394 331 345 436 382 415 352
328
423 454 359 399 327 339 430 379 414 351
326
467 ^--
548 360 401 337 320 389 330 350 340 347 376
379 345 337 356 331 322 372 330 367 336
--
338
---
371 358 344 334 390 391 392 350 ^---------
493
354 393 418
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND
^N--D---
ND
377 368 342 353 404 399 401 358
483
347 389 409 341 314 382 333 356 323 343 373 382 345 335 369 323 326 386 329 359
353
364 370 341 340 395 402 399 347
443 471 360 391 323 342 432 380 445 351
329
486
365 392 424 341 315 384 329 358 327 351 397 389 346 340 373 336 322 402 321 363
359
364 382 338 351 390 408 408 356
478 476 364 400 318 337 398 379 472 354
341
514
390 412 440 344 320 373 335 351 320 352 393 386 350 345 383 330 326 388 310 365
383
372 428 333 353 397 417 408 352
4---------
499 542
366 365
415
414
340 341
355 354
403
408
409
422
597 801
357 362 --------------D1 ead-
344 366
596 390 438 355 366 405 448
371
384
Dead-
531 546
--------------E
404
433
426
448
442
470
349
369
328
334
373 371
347 359
370 378
315 258
367 372
399 419
399 348
416 355
351
358
405
419
338 338
357 336
413
424
330
329
369 374
----- Dead--
-Dead-
427
470
------Dead--
391 513
413 584
339 346
358
373
383 416
373 452
416
419
365
367
-Dead----
571
439 465 492 390 342 371 366 382 ^----378 412 466 357 363 421 345 343 425 332 370
437
343 408
480 398 372
-Dead^-------412
368 350 427 469
390
-Dead-
402
385 418
------ --Dead1------------- ----------- V
358 337 339
362 , 360
379
-------Dead-------------3s
483
4------ Dead-------- ^
-Dead------------
*
393
426
495
422 495 <-.....Dead-
638
553 516 418 359 365 347 384
356 <5:----557 360 386 .45
351 u44 342 352
681
-Dead-
-Dead-
588
613
675
507 490 504
451
^-----Dead"--^
372 390 416
329 4--Dead---------->
334 ^--Dead--------- ^
393
430
460
-Dead-
388
406
433
-Dead--
-Dead-
356
347
346
393
406
415
485
590
697
--------- Dead----------
343
346
354
403
220
320
327 4;----- Dead--------
385
400
390
349 430
519 393 383
-Dead--
-Dead-
-Dead344
340
352
496
------ Dead---------^
--Dead---------------
554 362
4-- Dead-
360
352
<------------- Dead-
MEANrSD 363+35 38642 367+38 373+42 378+48 391r59 414+96 407+61 417+76 4229Q 403t94 432110
ND - No data was available on these rats.
SL 082097
TABLE A-2 (cont'd)
INDIVIDUAL AND MEAN BODY WEIGHTS3 OF FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING 200 PPM VINYLIDENE CHLORIDE FOR 730 DAYS
Animal _____________________________________________ Days on Test Number 100 139 181 210 238 266 294 330 357 385 413
74-3322 3323 3324 3325 3326 3327 3328 3329 3330 3331 3332 3333 3334 3335 3336 3337 3338 3339 3340 3341 3342 3343 3344 3345 3346 3347 3348 3349 3350 3351 3352 3353 3354 3355 3356 3357 3358 3359 3572 3574 3576 3578 3580 3582 3584 3586 3588 3590
MEAN+SD
280 277 313 264 309 254 307 273 308 276 281 293 268 316 280 324 276 278 282 308 280 312 303 275 272 285 316 310 313 307 304 315 264 287 299 247 266 281 309 280 297 270 290 298 283 272 298 283
289+19
306 ND
344 ND
334 ND
344 ND
341 ND
306 ND
312 ND
304 ND
301 ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND
338 ND
325 ND
327 ND
295 ND
328 ND
322+17
313 313 363 292 333 290 343 298 335 295 299 318 312 354 311 368 308 297 303 348 317 347 333 333 295 308 354 335 342 341 352 365 285 320 357 275 299 309 353 342 328 297 315 326 307 285 310 322
322+24
323 312 369 313 356 303 353 312 356 300 303 325 329 355 304 364 312 295
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND 355 330 334 311 328 351 312 293 290 298
32424
322 328 376 313 346 306 329 328 358 312 314 327 322 390 314 368 318 322 ND
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND 360 333 349 322 344 350 322 301 314 328
33322
328 333 373 322 372 308 381 320 374 312 313 335 333 418 326 378 320 342 ND
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND 365 349 354 322 346 361 326 310 324 337
342+27
318 340 386 324 375 313 388 315 380 302 339 314 329 422 325 384 333 345 353 387 326 365 365 363 326 337 382 350 320 335 375 363 363 392 307 329 362 297 368 338 316 308 365 347 328 300 325 351
34529
332 228 406 337 399 329 394 330 398 306 320 354 354 416 335 390 355 375 386 391 335 368 369 356 317 347 346 390 323 339 437 380 395 405 307 330 393 319 379 368 346 333 381 355 336 318 336 343
35637
332 349 400 340 408 320 387 349 399 304 330 353 334 427 334 397 360 372 361 401 319 367 373 351 316 335 392 357 316 333 481 383 384 421 301 326 385 301 382 367 336 349 366 358 337 314 328 352
35837
332 344 407 351 415 324 398 333 409 300 348 351 330 449 334 397 371 379 375 402 319 360 384 353 314 340 385 353 315 344 544 389 387 411 306 329 387 301 389 368 350 337 357 354 344 311 301 305
36045
336 367 415 382 422 339 412 350 437 313 402 361 356 461 314 374 425 380 398 410 329 374 400 367 326 345 403 355 323 340 610 408 417 430 305
331 405 314 399 362 317 Dead 368 359 346 327 354 341
375+52
Reports were already done for the first 97 days. ND = No data was available on these rats.
SL 082098
TABLE A-2 (cont'd)
INDIVIDUAL AND MEAN BODY WEIGHTS OF FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING 200 PPM VINYLIDENE CHLORIDE FOR 730 DAYS
Animal_________________________________________ _________
Number
441
469
472
497
533
Days on Test 568 596
___ ___________________________________ _____________ 629 ___652 687 715 729
74-3322 332 3 3334 3 3 25 3 326 3327 3 328 3329 3330 3331 3332 3333 3334 3335 33 36 3337 3338 33 39 3340 3341 3342 3343 3344 334 5 3346 3347 3348 3349 3350 3351 3352 1353 J JJ4 3355 3356 3357 3358 3359 3572 3574 3576 3578 3580 3582 3584 3586 3588 3590
MEANiSD
333 351 434 476 44 5 360 399 354 451 310
376 363 484 348 409 468 392 416 450 318 367 405 362 324 338 400 360 318 325 ----4 34
436 308 324 417 315 411 378 367
375 367 355 336 356 339
373248
334 349 442
452 352 414 366 490 318
382 370 527 352 423 407 390
ND
---
ND ND ND ND ND ND ND ND ND
ND
ND ND NO ND ND 404 390 370
381 373 360 338 359 346
388+49
ot
337 351 440
346 411 377 492 283
382 373 508 355 424 391 395 426
318 372
36 6 324 338 410 369 320
48b
450 310 318 + 28 328 395 391 368
377 371 352 342 359 341
380+51
337 357 4 54
+ 71 356 424 385 371 308
376 .378 526 367 485
415 435
371 376 418 381 324 331 405 3bb 316
533
4b6 no 324 432 331 iOO 402 371
376 366 353 350 368 347
38962
338 359 t------
jOO 364 481 400
304
393 387 <------
;o2
536
398 445
314 370 423 382 327 328 427 37 + 32 6
64 /
473 307 327 447 342 399 394 375
387 381 344 355 375 348
33^ 349 380 400
-Dead-
022
819
367 369
440 484
307 307 -Dead-
398 404 387 401
430 4o8
413 441
240
429 450 -Dead-
316
'.32 + 23
456 ^41
347 367 320 227 443 428 379 386 333 336
-Dead- -
--Dead -
Dead-
48b 506
311 328
324 457
338 502
353 359
404 415
412 389
423 372
--------------] Dead-
379 404
381 444
------370
382
423 436
351
344
346 367
364 374 385
425 600
----------Dead------ --
389 397 ------ --Dead521 602 ----------Dead---------313 326
-Dead392
328
38 3 -Dead-
357
399 359
404 387
405
420
----- --Dead--------
529
-Dead-
-Dead-
429
442
457 461
-Dead420 ND
-Dead-
-Dead467 458
446 46 1
-Dead-
-Dead--
440 + 51
436 484
426 494
396 554
354 582
379 365 380 340 346
-Qead-
434
451
422
418
424
412 461 537 642 697
338 309
--------- -- Dead---------
503 124 350 509 355 431 431 364
380 482
383 468 339
-Dead-
514 342 346 548 270 451 457 374
383 531
393 485 310
506 357 258 626
--
511 463
525
526
387 397
-e------ Dead------ -
-Dead-
-De ad-
664 Dead
487 499
-Dead-
360 356 359 ------ Dead"----------- **
386 531
--"
+02
431
----- -Dead---->
Dead----------- >
391+69 389+67 411297 41360 422280 4332:88 450il04 444*98
ND = No data was available on these rats.
f
SL 082099
TABLE A-3
INDIVIDUAL and mean daily food consumption for male rats maintained on drinking water CONTAINING 0 PPM VINYIIDENE CHLORIDE IN WATER FOR 731 DAYS
Animal Number 74-
_____________________________________________ _________Days on Test3
101- 105- 140- 143- 175- 178- 206- 210- 234- 238L05 108 143 147 178 L82 210 213 238 241
$066-7 3068-9 3070-1 3072-$ 307^-3 3076-7 3078-9 3080-1 3082-3 3084-3 3086-7 3088-9
3090-L J092-3 3094-5 3096-7 3098-9 3100-1 3102-3 3104-5 3106-7
3108-9 3110-1 3112-3 3114-5 3116-7 3118-9 3120-1 3122- 3 3124-5 3126-7 3128-9 3130-1 3123- 3 3134-5 3472474
3476478 3480482 3484686 3488690
12
23 29 28 24
22
'3 /
2)
19 25 31
12
28
21
25
20
26
21
24 24
24 25 25 23 23
MEANiSD 24r4
24 23 25 28 24 23 24 24 24 25 27 29 ND
21
26 26 26 23 24 24
26 24 26 ND 24 25t2
24 23 23 27
o >
22 22
ND 23 23 27
11
27
21
25 26 ND
22
24 23
ND 24 27 24
22
233
2-t
23 35 25 24 28 23 24 ND 23 24 13 2*
20
25 25 ND
21
25 23
23 23 26 24 25 24i4
14
28 24 29
22
23 23 24 26
22
24 23 23
20
27 26 25 24 25 26
24 25 47 44
22
26 + 7
74 23
22
26 24
22 22
23
22
23 23 23 ND
21
25 23 25
22
23 23
23 23 ND 23
21
23+1
23 24 24 27 23 23
22
23 25 23 24 24 24
21
25 24 ND 23 24 25
24 23 25 24
21
24 + 1
24 24 ND 28 24 23 23
4 25 24 23 25 23
21
26 25 26 23 24 24
24 23 25 24 23 24 + 1
24 23 25 26 23 23 24 24 25 24 25 24 28
22
25 27 25 23 24 25
23 24 24 ND 16 24 + 2
24 24 26 30 26 26 26 25 25 24 29 26 25
21
26 28 26 24 24 26
26 25 26 31 26 2b 12
262266
26 25 26 29 26 24 24 25 26 23 28 26 25
22
28 27 26 23 25 26
25 26 24 ND 23 25t 2
266269
25
22
26 29 25 2+ 32 25 ?7 25 26 ) -> 25
22
27 27 26
22
24 26
24 25 24 ND
21
252
290294
25 ''4
i/
28 24
21
23 24 25 23 26 24 25
20
25 26 24
22
24 27
24 24 25 24
22
24 + ;
29429 7
26
24 26 JO
21
23 27 26 27 24 26 25 25 23 26 26 25 23 24 26
23
21
25 26 23 25 + 2
325330
27 26 27 ND ND ND ND ND ND \D ND 25 ND 24 ND 27 27 24 ND ND
26 26 ND 28
22 2612
3 3033 -
29, ,7 V TN 37 JO 26 28
i2
31 3 28 33 > 36 26 77 26 30 36
28 27 31 27 28 29u
JThe first 100 days were previously reported, ND - No data was available on these rats.
SL 082100
TABLE A-3 (cont'd)
INDIVIDUAL AND MEAN HAILY FOOD CONSUMPTION FOR MALE RATS MAINTAINED ON DRINKING WATER CONTAINING 0 PPM VINYLIDENE CHLORIDE IN WATER FOR 731 DAYS
Animal Number 74-
381385
385388
406409
409413
440451
451455
46947 2
472476
Days on Test 498- 500- 532500 504 535
535539
546549
563567
595598
623626
651654
686689
714717
3066-7 3068-9 3070-1 3072-3 3074-5 3076-7 3078-9 3080-1 3082-3 3084-5 3086-7 3088-9 3090-1 3092-3 3094-5 3096-7 3098-9 3100-1 3102-3 3104-5 3106-7 3108-9
3110-1
3112-3 3114-5 3116-7 3118-9 3120-1 3122-3 3124-5 3126-7 3128-9 3130-1 3132-3 3134-5 3472S.74 3476678 3480fii82 3484686 3488690
26 25 25 28 26 23 25 25 26 J1 25 25 30 22 26 26 24 23 24 26
24 24 25 24
20
MEANiSD 25:2
25 24
27 26 23 34 24 24 25 25 23 28 21 26 26 23 23 34 25
24
22
24 23 23 253
27 ND
30 28 29 15 ib 28 16 27 28 30 24 28 31 29 26 15 18
25
21
27 28 23 25:5
28 26 26 29 27 27 26 26 28 27 26 27 30 23 28 27 26 25 26 27
25 ND 28 28
22
272
22 20
22 23 15 26 27 27 28 25 27 31 30 23 27 27 27 26 25 28
29 24 26 26 28 26+3
27 26
30 25 24 26 26 28 26 29 29 30 23 27 27 27 25 27 28
27 14 25 25 26 26:3
26
22
23 27
20
24 24 23
22 22
24 26 30 20 26 25 24
22 22
23
24 17
12
23
22
23:3
27 ND
29 19 24 24 25 26 25 26 25 30 20 25 26 25 24 25 25
23 ND 27 24 26 24 + 5
28 26 26 25
23 28 24 28 27 24 23
23 22 26 24 22 26 26 ND
25 23 30 26
26 24 20 19 29 26 22 22 24 28 24 24
25 24 27 26
24 <L-----
30 27 26
25
27 24 28
26:2 25:2
26 26
29 29 24 24 24 <----26
22
25 25 23 22
^--
29 24 24 25
26 23 21 30 28 24 24 24
26 25 26 27 24 28
ND 24 24 24
23 26
25 22
32 25 15
25+3
29 23 27
25 + 2
23 24 26 ;a 23 35 24
22 23 24 17 25 26 >7D
21 4-0ead-->
ND ND 16
------- !Dead------ ------ >
26 27 25 22 19 <rDead--^ 21 22 18 - > 24 16 Dead
21 2-f 23 20 20 21 25
23 23 23 24 24 25 26
--Dead--
------ >
24 25 21 33 25 25 29
26 18 16 36 24 23 ND
25 27 27 27 23 15 Dead
13 <r-
-Dead--
25 24 23 ND
29 32
30 25 27 3 7
25 23
-Dead--
28 25 20 35 17
DeadH*
24 20 24 24 24 21 23
26 23 24 36 22 22 Dead
25 24 21 32 24 23 ND
-Dead-
23 23 19 35 22 20 15
26 25 ND 28 26 25 27
24 ND
------- Dead*------- ->
29 <:----
-Dead------------------ ^
23 <- -----Dead------->
27 29 ^r-Dead-^
27 25 24 24
14 ^-Dead-^
33 24 32
t------ Dead------- >
^----Dead >
28 29
25 27
Dead
ND 26 29 23 23 19
--Dead--
--------------- ^
ND 27 ND ND 29 29 Dead
ND 22 21 22 14 22
24
ND 27
9 <6-- ----- Dead-- - >
22:5 23+3 22:3 27:7
ND = No data was available for these rats.
SL 082101
TABLE A-3 (cont'd)
INDIVIDUAL AND MEAN DAILY FOOD CONSUMPTION FOR MALE RATS MAINTAINED ON DRINKING WATER CONTAINING 50 PPM VINYLIDENE CHLORIDE IN WATER FOR 731 DAYS
Animal Number 74-
101105
3212-3 3214-5 3216-7 3218-9 3220-1 3222-3 3224-5 3226-7 3228-9 3230-1 3232-3 3234-5 3236-7 3238-9 3240-1 3242-3 3244-5 3246-7 3248-9 3532434 3536438 35406.42 3544446 3548450
23 22 25 ND 36 26 25 24 25
24 23 22 23 24
MEAN+SD 254
105108
24 23 24 32 29 26 29 25 26
25 25 22 21 27 25+3
140143
24 23 25 28 26 25 26 23 26
24 24 24 23 26 25+2
143147
24 24 23 29 22 25 26 ND 25
26 24 25 24 25 252
175178
24 25 26 32 27 27 27 25 26
26 25 25 24 26 26+2
178182 -
22 23 25 26 27 25 24 22 25
26 25 24 23 24 24+2
206210 --- -
24 23 23 30 27 25 26 25 26
26 25 22 26 27 25+2
Days on Test
210- 234- 238-
213 `
218
241
24 23 24 24 23 23 25 23 28 30 28 29 26 ND 28 24 24 25 27 26 27 24 24 24 23 24 25
25 25 25 26 25
25+2
25 25 25 22 24
24t2
26 26 26 29 25
262
262266
26 25 27 30 28 26 27 26 27
27 26 27 26 27 27+1
266269
23 25 26 30 27 23 26 25 29
26 ND 10 27 ND 25+5
290294
24 23 24 26 25 24 25 24 25
26 25 24 24 25 25+1
294297
22 24 24 29 27 24 27 24 24
28 26 25 24 26 25+2
325330
24 ND ND ND ND ND ND 28 ND
ND ND ND ND ND 26+2
330332
26 32 34 39 38 35 37 29 34
31 36 30 28 36 33+4
The first 100 days were previously reported. ND = No data was available on these rats.
SL 082102
TABLE A-3 (coat'd)
INDIVIDUAL AND MEAN DAILY FOOD CONSUMPTION FOR MALE RATS MAINTAINED ON DRINKING WATER CONTAINING 50 PPM VINYLIDENE CHLORIDE IN WATER FOR 731 DAYS
Animal ________ Number 381^ 38574- 385 388
406409
409413
448451
45l^ 455
469^ 472
472^ 476
Days on Test_____ __ __________________________________________ _____ 498- 500- 532^ 535^ 54<P 56> 595^ 623^ 6511 686^ lliZ 500 504 535 539 549 567 598 626 654 689 717
3212-3 3214-5 3216-7 3218-9 3220-1 3222-3 3224-5 3226-7 3228-9 1230-1 3232-3 3234-5 3236-7 3238-9 3240-1 3242-3 3244-5 3246-7 3248-9 3532434 3536638 3540642 3544646 3548450
25 25 26 30 30 25 30 26 26
27 26 17 23
20
KEANtSD 25+4
26 36
21
24 25 24 29 25 25
26
22
35 ND 37 27+5
26 17 28 30 ND 25 35 29 30
28 19 18 13 19 24+7
25 26 28 32 29 26 29 29 27
29 24 28 30 28 28+2
27 26 26 26 26 25 ND 31 33 29 26 24 31 36 27 ND 24 28
ND ND 34 28 31 27 32 28 29 27 29+3* 26+3
24 24
22
28 27
22
30 24 40
244 25 26 25 26+5
23 25
21
27 27 19 30 27 24
28 26 24 27 27 25+3
27 27 26
7 30
22
28 ND 27
28 26 27 30 28 26+6
24 26 25 ND 29 17 31 26 23
27 24 24 26 26 25=3
23 26 26 24 27 16 26 26
28 28 26 19 23 25+4
25 26 26
31 27 32
22 22
23 23
28 27 26 26 25 26+3
25
21
25
29 25 33 24 25 ND ND
ND ND ND ND ND 264
23 24 27
26 23 26 25 ND
12
ND
26 17
22 12
24 22+5
24 25 25 24 19 13 29 26 20 Dead * 17 30 ND 37 Dead
23 17
21
<-- 24 ^------
35 ----- -Dead----> <----------- Dead-----
--Dead-
------ *
30 19 26 26
-Dead-
--^
23 25 24 27
-Dead-
------ >
25 ND 24 23 14 21 4------Daad~---------- >
<=------- Dead-------- -->
4-------------Dead----- <--------- Dead--------------- ^
ND ND 26 29
29 29 4----- "Dead----> 22 27 4----- -Dead---->
12 24 33 25 Dead
4-------
--Dead-
--
29 29 21
4"Dead-^-
21+5 28+4 228 26+5 23+6
Significantly different from control mean by Dunnett's test, p<0.Q5. ND = No data was available on these rats.
SL 082103
TABLE A-3 (cont'd)
INDIVIDUAL AND MEAN DAILY FOOD CONSUMPTION FOR MALE RATS MAINTAINED ON DRINKING WATER CONTAINING 100 PPM VINYLIDENE CHLORIDE IN WATER FOR 731 DAYS
Animal
Number 74-
______________________________________________________________ Days on Test:3
101- 105- 140" 143- 175- 178- 206- 210- 234- 238105 108 143 147 178 182 210 213 238 241
262266
266269
290294
294297
325330
330332
3174-5 3176-7 3178-9 3180-1 3182-3 3184-5 3186-7 3188-9 3190-1 3192-3 3194-5 3196-7 3198-9 3200-1 3202-3 3204-5 3206-7 3208-9 3210-1 3512614 3516618 3520622 3524626 3528630
28 26 26 25 24 29 37 26 24
22 21 24 21 23
MEAN+SD 26+4
28 26 27 27 26 29 ND 27 25
23 24 20 23 26 25+3
26 25 27 27 27 24 ND 27 24
22 24 28 26 26 25+3
25 25 25 26 26 26 33 26 25
21 23 14 22 25 25t4
23 26 27 28 lb 28 46 30 24
23 25 35 26 27 27i6
24 26 25 26 26 23 25 26 26 27 24 25 25 27 28 25 26 26 28 24 23 26 25 26 28 25 26 24 24 24 29 33 35 26 25 27 28 29 29 29 23 26 26 25 27
22 16 23 22 25 23 24 24 23 25 37 36 38 32 35 23 25 26 24 26 23 25 26 26 26 254* 26+4* 27+4* 26+3* 27+3
28 28 23 27 29 27 30 29 28 28 26 31 ND 24 31 30 26 26
24 23 26 26 33 32 27 26 28 26 28+2* 27+2
27 26 27 26 25 ND 26 22 22
22 24 32 24 25 243
25 26 30 29 25 ND 20 ND 24
23 23 29 24 ND 24+4
ND ND ND ND ND ND ND ND ND
ND ND 35 ND 22 299
56 37 ND 39 37 ND ND ND 29
31 31 35 35 25 34+4
aihe first 100 days were previously reported. *
Significantly different from control mean by Dunriett s test, p<0.05.
ND * No data was available for these rats.
sl 082104
TABLE A-3 (cont'd)
INDIVIDUAL AND MEAN DAILY POOD CONSUMPTION FOR MALE RATS MAINTAINED ON DRINKING WATER CONTAINING 100 PPM VINYLIDENE CHLORIDE IN WATER FOR 731 DAYS
Animal
Number 74-
381385
38S388
406409
409413
448451
451455
469472
472476
Daya op Teat
498- 500- 532- 535- 546- 563- 595- 623- 651500 504 535 539 549 567 598 626 654
686689
714717
3174-5 3176-7 3178-9 3180-1 3182-3 3184-5 3186-7 3188-9 3190-1 3192-3 3194-5 3196-7 319Q-9 3200-1 3202-3 3204-5 3206-7 3208-9 3210-1 3512614 3516618 3520422 3524426 3528630
28 26 26 ND 26 27 24 33 24
23 24 34 25 25
MEAN+SD 26+3
25 25 26 28 25 28 24 25
22
22 20
34 24 24 25+3
29 28 27 29 29
21
27
12
24
26 26 19 26 14 24+5
29 28 28 28 28
21
27 ND 24
25 27 18 26 13 25+5
27 27 29 27 28 23 27 32 25
24 25 ND 26 28 27+2
27 26 26 31 28 30 27 32
22
24 25 34 25 26 27+3
16 29 24 26 24 17 24 31
21
22
23 32 24 24 245
15 28 25 29 26
22
26 32 23
21
27 35 28 27 26+4
29 26 26 28 27 36 28 31
22
21
26 32 26 28 28+4
28 24 26 28 25 31 24 31
22
23 24 30 25 28 26+3
28 26 34 19 24 27 27 19
23 24 17 19 25 24+5
25 25 30
22
16 24 26 23 23
15 19 18 26 22+4
HCO -a (j
28 25 30 32 32 24 30 26 23 30
15 24 26+5
20 22
29
22
ND 24 25 24 19 19
20 21
10 22
21+4
26 29 10 23
9
17 19 <---"Oead"-->
12 28
------ -Dead-
<-- <----28
<--
11
--Dead-- --Dead-- 27 19 --Dead-- ND ` 20
22 22
--> ----->
11
--> Dead
24 30 ND -s-Dead-->
12 4---------- Dead------- --> ( ------ .---Dead------------------>
23 32 ND 20
24
23 29 29 HJead->
28 ND 27 27 10 ------- Dead------->
8 <H)ead-^ 28 ND ND
23 22 16 24 28 ND 28
16 24
20+6
4---------------- Dead----------1 > 23 25 26 24
26+6 19+8 24+2 25+12
ND * No data was available for these rats-
SL 082105
TABLE A-3 (conn'd)
INDIVIDUAL AND MEAN DAILY FOOD CONSUMPTION FOR MALE RATS MAINTAINED ON DRINKING WATER CONTAINING 200 PPM VINYLIDENE CHLORIDE IN WATER FOR 731 DAYS
Animal Number --74---
101: 05
3 I 3r-7
3 L 38-- y 3140-^ 3 ill-3 J14-+-5 3116-7 3148-9 31:0-1 3152-3 315 4-5
3 lib-7 3153-^ 3160-1 3152-1 Jlo4-5 3156-7 3168-9 3170-1 3172-3 34912^94 3496698 3500^04 35064u8 1310
::
2 >1
2i
_ *t 2b 2-v
22
2i
_4 33 25 23 - -f
MEAN SD 24-5
105108
30 13
,0
23
22 22
_4
2o 13 13 24 23 23l4
140i43
' j_ 13
22
_3
_6
13 24 25 37
24 13 18 13
22
1311
14314 7
> i
22
23 23 25 2*
22
25 2b
) ^
23 23
21
23 2312
175178
> + 23
22
2~ 27 25 23 2o 2^
2b
23 24 23
2+ 2, zu
182
22
> > 25 16
22 21
23 23
22
oi 13 23 ,, - 2312
CD
206-
210
24 1) 26 2^ 2-r 24 2b
2^ 24 25 25 24 2312
Days on Test 210- 234- 238213 238 341
7 ' > 1 > +
23 2- 25 24 22 23
17 D -J _M
2? 27 38 25 26 24 2; 13 33 26 26 28 28 ND 27
25 25 2^
24 25
2 512
26 24 25 25 26
2 5i2
26 25 26 26 26
2512
26226 6
'7 25 23 28 27 '5 25 26 29
27 25 26 26 23 2612
266264
) > 25 24 28 30 25 23 23 31
26 25 25 27 26 2613
290294
>1 s
21
26 30 > ' 23
iy
27
26 25 25 25 26 24i4
294297
27 23 26 29 23 23 23 27
24 25 25 27 23 25 + 2
325330
24
51
25 ND 29 M3 26 ND NT)
ND 26 ND ND 28 26+2
330332
24 28 24 35 33 27 35 35 37
37 27 32 35 29 3115
first 100 Jays were previousi. reported nd = no 3a ta was av i l1ab le on the`-.tf rats.
SL 082106
TABLE A-3 (cont'd)
INDIVIDUAL AND MEAN DAILY FOOD CONSUMPTION FOR MALE RATS MAINTAINED ON DRINKLCONTAINING 200 PPM VINYL IDENE CHLORIDE IN WATER FOR 731 DAYS
Animal Number 74-
381385
385388
406409
409413
448451
451455
469472
472ill
Dava on Test 498- 500- 532500 504 535
535539
546549
563567
595598
623626
651654
686689
7147X7
3136-7 3138-9 3140-1 3142-3 31-14-5 3Uo-7 3148-9 3130-1 3 li> 4-- J 3154-5 3156-7 3138-9 3160-1 3162-3 3164-5
23 24
22
27 28 25 24 25 28
3168-9 3170-1 3172-3 3492494 3496498 3500404 3506-08 3510
26
24 26 26 23
mean^sd 252
21
24
22
26 27 24
22
25 Z"6
25
22
25 24 25 24 + 2
25 26 24 28 14 26 24 26 29
17 26
22
ND 14 23*5
24 27 25 27 15 30
21
ND 29
27 28
21
28 30 26+4
30 26 33 28 27 26 31 29
27 26 15 29 29 26+4
23 2"
1 30 26 24 28 28
26 27 26 29 25 15*2
a
.* :i 27 4---
23 25 25 26
23 26 25 27
25 25 29 27
25 24 26 26 24
252
26 26 27 29 27
262
27 26 27 28 24 26
21
26
22
26 29 30 27
26*2
24 26 24 27 23 24 ND 36
22
25 27 27 26 15*2
25 25
22
26
20
26 26 26
16 28 30 26 27 25+4
26 25 23 26
21
26 30 26 25
22
25 26 26 24 24+4
27 28
21
... 23 15 24 24
22
'2 b
26 24 27 21
21
24+4
24 19 30 31 27 37 22 20 27 ND
22 23 24 23 19 22 25 18 25 24
22
25 25 12 lit <-----
.23
10 28 30 32 27
24 24 17
TO
22 33 27
27 27 <--
27 24 16 30 31
-- Dead----
-----
--------Dead----
<-----
--Dead-
--6.
13 37 33 ^"Dead-->
11 26 27 Dead
15 <r-Dead--^
4------ --Dead------- >
}Q 24 26
13 23 24
20
22+4
13 24 28
28
21+6
20 <;-------
------ >
29 7 26 15
ND 33 33 31
----->
<5----- ------- Dead------- -->
26+6 24+8 27 + 4 27+6
N'D = No data was available for these rata.
SL 082107
TABLE A-4
INDIVIDUAL AND MEAN DAILY FOOD CONSUMPTION FOR FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING 0 PPM VINYLIDENE CHLORIDE IN WATER FOR 730 DAYS
Animal Number 74-
101105
105--1--08--
3350-1 3252-3 3254-5 3250-7 3258-9 3260-1 5262-3 32o4-5 3266-7 3268-9 3270-1 3272-3 3274-5 3276-7 3278-9 3230-1 3282-3 3284-5 3286-7 3288-9 3290-1 3292-3 3294-5 3296-7 3298-9 3300-1 3302-3 3304-5 3306-7 3308-9 3310-1 3312-3 3314-5 3316-7 3318-9 3552-4 3556-8 3560-2 3564-6 3568-70
17 19 17 24 20 16 13 20 13 13 2L 23 13 :8 18 L7 19 18 17 22
19 zo 19 19 26
20 21 19 22 20 21 18 ]_ 7 18 19 19 18 19 17 19 16 19 19 IS 26
26 20 19 21 19
140143 "-----
21 20 18 20 20 19 20 20 17 19 19 18 19 17 23 16 20 20 16 22
21 19 20 19 17
143147
18 19 19 21 19 19 18 19 17 17 20 18 17 18 21 18 1.8 19 17 21
20 16 19 19 17
175178
22 29 20 27 '> 26 20 20 15 18 IS IS 19 19 1t 17 20 19 13 34
19 18 18 22 14
178182
17 20 17 23 19 21 24 17 17 18 16 20 15 18 17 16 13 17 17 26
19 l7 18 20 20
210
19 19 18 ND 18 18 22 17 17 19 21 19 19 19 18 17 17 19 21 22
17 16 19 21 17
1
oXJ
tN
Days on Test 3 210- 234- 238213 238 241
262266
21 19 27 21 21 19 22 21 17 17 20 ND
25 26 23 ND 19 21 22 22 18 18 18 20 31 22 35 ND 18 19 20 19 18 18 18 20 20 19 20 29 19 25 20 24 17 18 22 22 19 17 19 21 20 19 21 20 19 19 21 20 17 17 18 19 20 18 23 19
19 24 20 24 18 26 20 24 22 ND ND 32
266269
21 20 20 21 22 19 26 19 19 19 19 19 20 18 20 15 19 21 21 26
290294
18 20 18 21 21 19 19 21 20 19 22 18 19 18 17 17 18 18 19 21
294297
325330 --
19 21 20 22 21 21 19 20 22 26 20 19 21 20 19 20
16 18 22 22 21 22
18 ND 18 22 18 20 17 20 17 17
16 19 18 20
17 17
18 24
330-3--3--2
20 21 20 21 26 20 26
18 20 19 26 ND 21 22 20 17 22 17 14 23
19 19 21 19 20 26 20 17 22
18 19 19 20 19 13 17 20 20 19 19 26 22 22 ND 25 ND ND 20 23 19 25 24 19 19 23 23 18 18 21 22 24 19 22 22 28
MeaniSD L 9 2 19 + 2 192 19tl 20r4 19r3 19+2 203 20r3 21 + 4 2 25 21 + 3 192 19+2 20+2 21+3
aThe first 100 days were previously reported. ND - No data available.
SL 082108
TABLE A-4 (copt'd)
INDIVIDUAL AND MEAN DAILY FOOD CONSUMPTION FOR FEMALE RATS MAINTAINED ON DRINKING MATER CONTAINING 0 PPM VINYLIDENE CHLORIDE IN WATER FOR 730 DAYS
Animal
Number 74-
381385
385388
406409
409413
448451
451455
469472
Day op Teata
472- 498- 500476 500 504
532535
535539
546549
563567
595598
623626
651- 654
686689
714717
3250-1 20 18 23 22 ND 20 17 21 21 19 ND 28 19 14 25 <------ ----Dead--------- ----- >
3252-3 20 18 24 77 21 23 19 22 20 14 ND 40 19 18 22 L 7 ------- --Dead-------4
3254-5 18 19 20 20 19 19 18 20 19 19 ND 24 10 19 13 25 ND 24 25
3256-7 ND 25 ND ND 23 21 17 16 24 22 ND ND 35 <---
--Dead-
--^
3253-9 21 19 11
n 25 26 23 27 28 21 ND ND 25 24 23 39 23 29 Dead
3260-L 20 20 19 23 18 23 18 21 19 20 ND 28 20 16 ND 34 22 22 15
3262-3 24 23 40 36 31 ND 19 23 26 22 ND ND 22 20 25 25 29 23 Dead
3264-5 18 17 ND ND
19 16 16
3266-7 18 17 17 24 17 10 15 20 22 20 ND 38 13 15 22 21 ND 19 20
3268-9 19 19 26 25 21 3 ; 20 18 20 20 ND 20 19 22 22 28 40 ^-----Dead--^
3270-1 20 27 19 33 29 2 r
29 26 25 ND ND 23 22 11 29 32 16 ND
3272-3 18 17 16 21 ND ND 31 ND ND ND ND ND 18 19 ND 21 24 20 10
3274-5 18 16 23 22 22 29 21 20 18 18 ND 29 14 17
9 21 31 21 17
-->3276-7 21 18 25 20 21 21 18 18 24 20 ND 29 ND 18 17 24 ----- --Dead--
3278-9 19 20 12 20 23 19 19 21 19 19 ND ND 17 22 22 32 29 17 23
3280-i 16 17 12 18 19 19 17 18 18 17 ND 27 15 15 16 19 19 21 21
3282-3 18 18 21 22 19 19 18 19 18 20 ND 37 16 17 18 21 22 20 24
3284-5 20 19 29 21 23 22 18 21 22 20 ND 28 17 18 21 12 28 23 Dead
3286-7 18 16 19 21 19 20 17 20 20 18 ND 30 20 ND 29 23 ----- --Dead*--------^
3288-9 22 22 ND 25 24 23 ND ND 24 ND ND 40 20 21 22 30 ND 24 Dead
3290-1
ND ND 40 16 19 22 19 23 22 21
3292-3
11 38 <-------
-Dead-....
3294-5
23 24 21 21
3296-7
29 30 22 24
3298-9
25 20 24
3300-1
26 21 25
3302-3
<--------- Dead------
3304-5
22 19 19
3306-7
ND ND 18
3308-9
ND 20 Dead
3310-1
21 21
3312-3
37 27
3314-5
21 22
3316-7
20 22
3318-9
27 Dead
3552-4 19 19 ND 23 21 20 17 19 20 22 ND 33 ND 19 23 28 42 27 Dead
----3556-8 19 17 17 20 22 21 1" 19 13 16 ND 28 ND 18 18 25 < -Dead---------V
3560-2 17 ND ND 27 25 33 22 ND 22 22 ND 32 ND 17 22 31 <--------Dead `V
----3564-6 20 22 24 23 22 23 17 22 22 21 ND 31 ND 16 27 30
-Dead----
3568-70 22 23 21 24 21 19 21
24 23 ND 31 ND 16 19 13 21 17 18
MeaniSD 192 19+3 21 + 7 22+6 22 + 3 22+4 19+4 2 0 3 22+2 20+2 ND
31+6 195 18+3 226 25+6 26+5 22+4 21+4
NO = No data available.
SL 082109
TABLE A-4 (cont'd)
INDIVIDUAL AND MEAN DAILY FOOD CONSUMPTION FOR FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING 50 PPM VINYLIDENE CHLORIDE IN WATER FOR 730 DAYS
Animal Number 74-
101105
3398-9 3400-L 3402-3 3404-5 J40b"7 3408-9 3410-1 3412-3 3414-5 3416-7 3418-9 3420-1 3422-3 342 -- 5 3426-7 3428-9 34 30-1 3432-3 3434-5 3612-4 3616^8 3620-2 3624-6 3628-30
17 20 16 23 17 ]7 18 19 16
2} 20
i7
6 18
105108
18 21 19 20 25 77 13 19 20
21 21 25 18 19
140143
' 22 20 16 > y 17 1b 17 24 17
19 17 23 17 19
143147
19 19 16 21 13 17 17 "> o 19
20 21 25 17 18
175178
ND L9 18 17 21 1b 21 21 18
20 17 23 19 19
178182 -""TM
]_ 7 L9 L9 20 L7 17 15 18 15
19 17 23 17 16
206210
17 19 17 22 18 15 19 19 19
ND 18 18 18 19
Days on Test a 210- 234- 238213 338 241
262266
18 19 30 21 21 20 29 ND 19 17 30 20 1 -> 18 28 21 19 18 29 20 l~ 17 27 18 18 18 29 21
22 20 32 20 13 18 30 20
ND 33 25 22 27 18 20 20 26 21 26 22 17 17 19 19 20 19 20 19
266269
19 21 25 1; 20 17 17 20 21
13 19 22 19 20
290294
17 20 18 20 19 17 18 22 18
22 17 17 17 18
29479 7
ND ND 17 13 1,9 16 18 ND 15
23 19 20 18 21
325330
ND ND 21 37 23 18 ?b 19 22
ND 18 20 '19 22
330332
ND ND 21 2 j. ND
i7
21 24 22
34 17 21 20 18
Me inSD 20-3 20s2 19 3 19t2 19 2 1812 1812 2013 19i4 274 * 2011 19t3 19+2 182 213 22 + 5
'.he first 100 days vers previously reported.
*S ignir icantly different from control mean by Dunnett'a test, o ''O.Oo ND = No data available.
SL 082110
TABLE A-4 (cone'd)
INDIVIDUAL AND MEAN DAILY FOOD CONSUMPTION FOR FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING 50 PPM VINYLIDENE CHLORIDE IN WATER FOR 750 DAYS
Days on Test 381- 385- 406- 409- 448- 451- 469- 472- 498- 500- 532- 535- 546- 563- 595- 623- 651- 686- 71474- 385 388 409 413 451 455 472 476 500 504 535 539 549 567 598 626 654 689 717
3398-9 19 16 20 19 19 13 IS 22 19 16 33 ND 18 19 22 22 24 23 Dead
3400-1 20 19 20 21 21 23 17 23 23 22 37 16 21 22 ND 23 u 25 Dead
3402-3 24 17 10 26 20 33 41 18 31 36 31 ND 17 16 ND 22 ND 19 20
3404-5 20 18 26 24 25 23 20 23 23 21 34 13 19 20 23 24 a
Dead--*
3406-7 18 20 23 21 21 22 17 20 21 20 33 11 20 19
9 24 21 23 23
3408-9 16 15 18 17 19 19 16 17 IS LS 29 ND 17 17 ND' 18 ND 19 19
3410-1 18 21 22 20 22 23 19 20 26 22 ND ND 11 21 ND 26 ND i-- Dead-->
5412-3 19 21 27 24 21 22 21 24 24 17 36 14 23 19 ND 24 28
Dead--
3414-5 ND 19 19 23 19 18 17 20 16 29 29 10 19 17 ND 19 12 21 18
3416-7 3418-9
3420-1 3422-3 3424-5
ND 16 16 22 22 20 21 21
11 ND 18 13 ND 25 40 40
<--
Dead
---------- >
1/ 21
21 Dead
3426-7
20 20
3428-9 3430-1 3432-3 3434-5
"6--
Dead --
18 19 19 20
---------- y
22 21
3612-4 20 19 21 25 23 21 19 21 22 22 34 12 21 ND 23 35 27 21 26
18 19 22 21 21 21
al i 12 29 36 26 32
Dead
3624-6 18 18 19 17 19 19 20 18 19 18 29 10 26 ND 15 18 19 19 19
3628-30 19
21
9 28 18 28 18 20 19 20 26 13 12 ND 36 39 14 ND 20
MeanlSD 19*2 192 19*5 21*4 2113 23l5 216 21*4 22*4 22*6 32*3 12*2 184 19*2 22*:7 24*6 22*6 22 + 5 223:6
ND - No data available.
SL 082111
TABLE A-4 (cont'd)
INDIVIDUAL AND MEAN DAILY FOOD CONSUMPTION FOR FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING 100 PPM VINYLIDENE CHLORIDE IN WATER FOR 730 DAYS
Animal Number 74-
101105
105108
140143
143147
175178
178182
206210
Days on Tear 210- 2 34- 238213 238 241
262266
266269
290294
294297
325330
330332
JJ60-1 19 21 18 17 20 19 18 17 IS 22 20 26 ND ND 19 ND
3362- 3 16 17 15 15 15 16 17 18 17 18 L8 21 19 13 18 18
3 364-5 16 16 16 15 17 13 15 16 17 17 17 17 16 18 17 17
3366-7 16 17 19 21 17 18 20 17 22 20 22 19 20 ND 17 19
3363- 9 20
20 16 18 19 19 17 20 20 20 22
71
20 ND ND
33
3370-1 17 19 20 20 20 18 19 19 18 21 23 19 18 H 13 ND
3372-3 18 20 19 20 21 17 20 19 20 21 23 21 22 21 25 22
3374-5 21 21 19 18 16 18 19 18 18 24 21 18 19 19 20 31
3376-7 ND 21 17 14 18 16 ND 21 20 18 22 22 18 18 20 39
3378-9
3380-1
3382-3
3384-5
3386-7
3388-9
3390-1
3392-3
3394-5
3396-7
3592-4 24 25 18 17 18 18 19 19 ND 35 26 21 22 31 19 21 3596-8 17 19 16 18 16 18 17 18 19 22 20 17 17 17 18 17
3600-2 23 21 21 18 19 18 17 20 20 21 21 18 18 21 21 30 3604-6 21 20 19 19 21 18 20 19 20 19 24 25 16 20 24 20 3608-10 22 25 19 21 21 20 21 22 23 23 23 21 20 21 ND 26
V-1 LO +1
MeantSD L9 3 20+3 18+2 18+2 19+2 18+2 182
19+2 21+4 22+2 20t3 18+3 21+8 193 2417
NO = No data available.
TABLE A-4 (cont'd)
INDIVIDUAL AND MEAN DAILY FOOD CONSUMPTION FOR FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING 100 PPM VINYLIDENE CHLORIDE IN WATER FOR 730 DAYS
38174- 385
3360-1 3362-3 3364-5 3366-7 3368-9 3370-1 3372-3 3374-5 3376-7 3378-9 3380-1 3382-3 3384-5 3386-7 3388-9 3390-1 3392-3 3394-5 3396-7 3592-4 3596-8 3600-2 3604-6 3608-10
20
19
16 20
19
22
24 19 18
23
18 21
23
21
385388
20
17 16 ND
20
24 19
21 20
18 18 17 23 17
406409
12
19 19 18 24 28 48
22 21
15 19 25 25
22
409413
19 19 18
21 20
23 25 23 17
14 18
21
18 23
448451
22
18
20 22
6
36 26 23
22
37
20 21
24 35
451455
20
17 19
20
ND
21
44 25
20
26
21 21 22
24
469472
17 18 15
20
4 23
22
23 19
ND 17
20
19 18
Days on Test 472- 498- 500476 500 504
20 38 23
18 17 18
17 18 17
18 22 20
25 22 22
25 24 31
29 28 26
28 23
25
20 21 18
23 31 ND
ND 20 19
19 22
2-
20 23
25
ND 30
28
532535
ND ND ND ND ND ND ND ND ND
ND ND ND ND ND
535539
ND ND ND ND ND ND ND ND ND
ND ND ND ND ND
546549
17 16 16 19
20
24 24 25 18
18 19 19 17 27
563567
20
16 15
20 20 20 20 22
18
21 20
17 19
21
595598
ND 14 24 29 29 ND ND ND 18
ND 19 24 16 26
623- 651- 686- 714626 654 689 717
--35 <r- Dead -- >
21 ND 18 21
21 ND 18 17 24 27 19 Dead 37 22 31 33
33 10 29 Dead 29 ND 32 Dead 30 - Dead-------- > 21 ND 20 22
ND ND 23
ND 14 Dead ND 18 28
22 21
21 22
22 21
20 26 17 20 23 24
<-- Dead--^
32 <---- Dead --------> 24 ND 24 24
25 ND 31 Dead 22 ND 24 26
29 31
Dead -->
MeantSD 202 19+3 21*4 20+3 23+8 21+3 18+5 22+4 24+ 5 22 + 4 ND ND 20+4 19+2 21+5 27 + 5 23+ 9 2215 24+4
MB - No data available.
SL 082113
TABLE A-4 (cont'd)
INDIVIDUAL AND MEAN DAILY FOOD CONSUMPTION FOR FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING 200 PPM VINYLIDENE CHLORIDE IN WATER FOR 730 DAYS
Animal Number 74-
101105
105--108
3322-3 3324-5 3326-7 3328-9 3 3 30- l 3 332-3 3334-5 3336-7 3338-9 3340-1 3342-3 3344-5 3346-7
3348-9 3350-1 3352-3 3354-5 3356-7 3358-9 3572-4 3576-8 3580-2 3584-6 3588-90
18 22 18 18 18 17 19 18 16
20 20 19 19 22
18 21 19 18 19 16 19 20 17
21 17 20 23 24
140143
17 18 17 21 17 16 23 17 18
18 17 16 18 20
143147
17 18 17 19 19 18 17 20 19
20 18 18 17 18
175178
ND 19 ND 19 17 18 20 19 22
20 18 19 21 21
178--182
15 18 17 16 17 17 17 21 18
20 17 18 15 22
206210
16 18 17 20 18 18 21 19 19
17 18 20 18 ND
Days on Test4 210- 234- 238213 238 241
19 12 ND 18 24 37 16 27 ND 20 16 19 19 23 ND 18 24 20 22 22 28 20 10 31 20 16 23
18 15 18 17 19 19 19 20 21 20 19 21 32 19 20
262266
13 21 21 19 2 20 21 22 26
17 18 21 21 21
266269
18 21 18 20 20 19 17 ND 19
19 19 21 20 23
290294
15 18 17 19 13 18 18 20 18
18 ND 20 17 20
294297
16 19 17 19 13 lb 18 19 16
17 ND 18 17 19
325330
13 18 21 '0 20 21 19 20 20
23 18 20 20 22
330132 --
16 21 24 21 21 29 21 28 20
22 18 23 24 22
MeaniSD 1 92 19+2 1812 18 + 1 19+2 18 + 2 18 + 1
o
14 -P-
19+5 23+6 21 + 2 19+2 18+2 18+1 202 22+3
a The first 100 days were previously reported.
N'D = No data available.
SL 082114
TABLE A-4 (cont'd)
INDIVIDUAL AND MEAN DAILY FOOD CONSUMPTION FOR FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING 200 PPM VINYLIDENE CHLORIDE IN WATER FOR 730 DAYS
Davs on Test
n-
381385
385388
406409
409413
448451
451455
469472
472476
498500
500504
532535
535539
546549
563567
595598
623626
651b54
686689
714717
3322-3 3324-5
16
20
16 ND
23 ND
18
22
18 L8 29 ND
16
22
15 24
17 27
17 17 21 27 <--
17
19 18 22 Dead -
17
22 23 --^
3326-7 18 15 20 19 19 22 17 21 17 17 19 19 16 20 26
4 22 16 27
3328-9 19 21 11 32 19 22 16 30 20 17 19 19 18 26 ND 36 4------- Dead ----->
3330-1 26 21 16 22 22 21 20 15 22 21 23 22 23 20 24 36 41 28 26
3332-3 20 21 ND 20 20 20 16
8 20 20 18 20 18 17 14 22 24 4r Dead-->
3334-5 18 21 21 20 23 20 18 25 21 20 21 20 19 ND 19 21 17 20 19
3336-7 19 18 21 18 20 38 21 24 22 23 22 24 36 ND 31 37 4--------- Dead ----- >-
3338-9 19 21 12 18 20 20 19 30 23 22 20 23 18 ND ND 12 29
Dead--^
3340-1 3342-3 3344-5
23 13 16 12 ND 23 21 23
4------
--Dead--
-->
12 22 21 ND
3346-7
22 ND
3343-9
22 24
3350-1
^--Dead--
3352-3
<--Dead-->
3354-5
27 23
3356-7
19 22
3358-9
20 Dead
3572-4 22 22 24 20 ND ND 19 23 21 17 18 19 20 18 15 26 22 20 27
3576-8 12 m 15 ND ND ND 18 22 20 20 ND ND ND 18 ND 25 25
Dead--^
3580-2 16 17 18 19 ND ND 19 21 ND 21 19 21 16 17 15 24 23 16 24 3584-6 ND 24 20 21 ND ND 19 25 ND 24 21 22 20 ND 40 ND 22 30 23 3588-90 nd ND 19 22 ND ND 18 20 22 ND 37 21 40 ND 23 ND 16 24 Dead
MeaniSD 19.+3 20+3 18+4 2114 20+1 23+6 1812 22l6 21+3 20+3 21+5 2112 21+8 19+3 22*8 23+10 22+4 224 24;
ND No data available.
SL O82115
TABLE A-5
INDIVIDUAL AND MEAN DAILY WATER CONSUMPTION OF MALE RATS MAINTAINED FOR 731 DAYS ON DRINKING WATER CONTAINING V1NYL1DENE CHLORIDE
Anbul Nuabers
3066-7 3068-9 3070-1 3072-3 3076-5 3076-7 3078-9 3060-1 3062-3 3084-5 3066-7 3086-9 3090-1 3092-3 3094-5 3096-7 3098-9 3100-1
3102-3 3104-5 3106-7 3X06-9 3110-1 3112-3 3114-3 3116-7 3118-9 3120-1 3122-3 3124-5 3126-7 3128-9 3130-1 3132-3 3134-5 3472-4 3476-8 3460-2 3464-6 3488-90
MEAN S.D.
104105
62 61 HD 45 37 34 38 47 40 63 41 43 52 49 45 27 41 34 38 ND
46 46 50 40 41
42 6
107108
42 62 66 43 60 35 62 66 38 60 40 35 50 ND 44 59 ND HD 39 44
ND 42 48 22 44
42 7
139160
42 62 60 53 61 62 65 47 43 67 46 25 18 52 69 ND 56 40 69 47
ND ND ND ND ND
43 9
142143
43 40 42 48 40 34 32 45 43 46 42 20 ND 48 43 ND 43 37 45 47
46 47 52 39 41
42 7
174175
40 38 45 45 43 41 39 46 47 45 42 46 52 51 50 59 44 36 44 45
56 47 49 47 41
45 7
177178
42 42 42 50 48 38 50 49 47 43 40 43 53 52 52 61 50 42 45 46
57 47 54 35 42
46 18
209210
44 39 36 47 40 38 44 40 52 46 40 38 53 44 44 47 35 36 43 50
57 45 48 42 40
44 6
Pays cm Teat - Control Hales
212213
237238
240241
265266
268269
44 42 49 52 46
38 42 41 97 ND 31 44 44 49 46 44 47 62 55 51
37 48 56 45 47 51 41 52 42 41 40 47 ND 52 51 49 51 ND 50 47 41 54 56 57 56
44 50 48 to 48
38 45 44 50 49 30 52 39 42 35 45 57 ND 58 54
43 53 53 54 53
41 ND 54 56 56
43 ND 59 TO 63
44 47 52 50 45
40 42 46 46 46
40 52 42 41 46
48 54 51 TO 55
ND ND ND ND 57 40 39 53 51 45 42 42 49 55 50 36 40 41 47 42 37 46 46 51 36
41 48 49 50 49 +5 16 6 5 7
293294
45 41 46 ND ND 43 45 54 57 48 52 38 61 46 48 62 46 39 47 ND
60 47 49 42 48
48 7
296297
43 43 52 52 40 35 44 51 53 52 43 32 58 45 46 47 42 46 44 54
49 56 28 30 50
45 8
331332
49 41 42 61 51 48 HD ND ND 51 46 33 HD HD 54 61 45 41 46 61
ND 47 52 43 39
48 8
335336
46 40 45 ND 43 49 50 46 ND 42 46 39 64 47 60 63 45 56 45 ND
ND 46 58 45 41
46 7
356357
58 30 45 58 47 45 52 45 46 44 45 36 57 44 50 ND 46 52 56 23
359360
57 41 46 54 37 42 49 ND 17 52 47 HD 59 47 46 ND ND 49 60 ND
61 ND 48 55 45 49 50 52 50 53
49 49 12 11
365386
56 44 55 54 49 46 47 59 36 49 51 34 ND 47 51 ND 51 43 50 ND
ND ND ND ND ND
49 7
387388
48 40 48 50 46 37 44 45 47 50 46 36 60 43 50 65 43 50 53 56
412-
ill
49 23 32 36 35 43 35 41 22 60 36 17 43 27 44 59 36 23 44 40
50 44 51 ND 47 33 54 38 33 21
48 37 7 11
ND No data available-
SL 082116
l ABLE A-5 (coat'd)
INDIVIDUAL AND MEAN DAILY WATER CONSUMPTION OF MAI E RATS MAINTAINED FOR 731 HAYS ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE
A ci mill Numbers
3066-7 3068-9 3070-1 3072-3 3074-5 3076-7 3078-9 3080-1 3082-3 30B4-5 3086-7 3088-9 3090-1 3092-3 3094-5 3096-7 3098-9 3100-1 3102-3 3104-5 3106-7 3108-9 3110-1 3112-3 3114-5 311W 3118-9 3120-1 3122-3 3124-5 3126-7 3120-9 3130-1 3132-3 3134-5 3472-4 3476-8 3480-2 3484-6 3488-90
415416
50 43 43 53 52 48 36 56 55 51 44 35 69 45 59 75 45 46 64 55
54 60 52 53 41
MEAN 1S-D.
51
19
440441
44 48 ND 72 ND 46 49 64 52 62 48 36 ND 47 75 ND 50 46 70
66
59 64 54 57 55
55 24
443444
44 43 ND 63 53 48 56 53 56 49 ND 45 ND 45
66
ND 48 42 63 73
ND
54 60 50
54 9
468469
52 45 65
60
51 43 42 42 42 34 53 43 19 45 65 ND 56 44 45 ND
73
38 57
60
49
12
4714_72_
48 45 60 69 52 43 hi 4o J5 45 50 44 ND 43 69 ND 50 51 49 14
Nl>
35 54 ND
47 13
Days on Teat - Control Haleb
499500
503504
538539
541541_
56656 7 ,
569570
5945_95
5b 64 66 bO ND 78 75 88 69 79 40 56 54 51 5b 60 41 45 46 67 63 64 50 50 ND 99 52 36 86 90 83 ND 56 58 51 45 59 60
68 68 --
ND ND
60 53 68 60
bl 61 64 5^
70 64 72 60
92 51 52 92
79 7b 94 84
50 41
50 4 l
62 59 6 5 60
b6 59 68 70
-------------- -- --
54 58 72 ND 59 ' 7 1 ! ND
49 15 52 58
ND ND <-----
61 54 70 66
82 66 ND 03
<-- ------
77 72 68 70
57 50 48 58
67 ND 58 66
75 66 82 83
--
62 ND 48 50 ND 58 97 67
ND ND ND 56
53 73 85 NO 97 55
66
67
75 70 70
ND 77
ND 94 66 90
68 64 97
<r-
84
62 ND 67 56 65 66 74
71 ND 73 69 75 79 83 7b 73 68 68 ND 66 74 65 94 ND 96 ND 97 69
bl 66 66 61 67 68 75 12 17 10 13 14 14 12
__ ______
597- 622598 _ 623
50 68 72 75 69 41 89 ~ tIU 90 NL> 14 60 60 62 77
625626
63 80 77
b7 65 75
650651
59 71 81
Nl> bb 42
653654
665-
686
688689
716717
720 721
68 80 80 81 ND
79 94 91 95 95
76 <--------- --Dead--
------ >
------ Oead-8! 83 93 53 55 42 79
--DeadND Dead--> 52 52 57
72 71 79
68 61 28 52 63 70
39 59 79 74
57 65 60 53 67 72 60 81
-Dead80 67 96 63 58 75
53 67 62 ND
80 53
99 ND 58 62 58 <--
6b ND 69 ND ND ND 99
54 71 5/ 61 97 78 74
69 ND 71 57 45 --Dead
----- Dead-
60 HI) 98 86 75 B8
74 89 ND 92 86
--^
66
ND
44
<---------- Dead-
-------->
55 56 62 66 56 62 66
80 91 ND 78 80 <--Dead-->
86 85 ND 31 64 ND Dead
67 ND ND 74 58 41 32
77 66 62 75 78 80 ND
80 <------
-------- Dead----------
--*
--Dead-
--Dead-
78 66 ND 27
75 76 70 77
92 ND
67 40 47 <:-- -Dead-
-->
57 57 83
62 60
-Dead--
-->
-Dead-- 85 80 86 64 75 82 ND 88
--Dead-
ND 6b 59 66 74 --4-B-------4>4
ND ND ND 97
ND <--Dead->
ND
56 ND 59 ---------- Dead--
52 --4-5-------5>0
66 64 72 67 64 73 73 71 70 16 13 10 15 13 19 16 10 20
hl> - No data available.
SL 0 8 2 1 1 7
TABLE A-5 (tout'd)
.INDIVIDUAL AND MEAN DAILY HATER CONSUMPTION OF MALE RATS MAINTAINED FOR 731 DAYS ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE
Animal Numbers
3212-3 3214-5 3216-7 3218-9 3220-1 3222-3 3224-5 3226-7 3228-9 3230-1 3232-3 3234-3 3236-7 3238-9 3240-1 3242-3 3244-5 3246-7 3248-9 3532-4 3536-8 3540-2 3544-b 3548-50
MEAN iS.D.
104105
ND 56 54 27 ND 42 41 38 47
43 40 41 39 48
43
8
107108
43 43 ND 50 50 42 ND 38 45
45 36 56 ND 42
44 +b
139140
42 49 51 ND 48 44 49 42 51
49 49 49 48 50
47 3
142143
43 45 55 59 46 45 47 39 53
48 37 4b 43 45
46
6
174175
40 47 57 54 47 45 45 39 46
50 39 49 46 45
46 5
177178
43 46 52 56 50 47 49 39 46
209-
210
44 49 33 56 48 40 47 41 53
Days on Test - 50 ppm Males
212213
237238
240241
26526b
268269
39 23 35 50 47 40 36 51 51 49 51 38 5b 51 53 48 39 55 t>9 61 46 40 59 67 65 39 34 39 51 ND 48 37 52 53 45 40 31 38 48 40 ND 32 43 bl 60
293294
44 52 48 44 ND 48 50 48 55
296297
40 47 47 53 60 4b 43 ND 49
331332
43 63 bl ND ND 51 57 32
66
52 54 50 48 49 51 54 54 45 58 48 40 41 40 42 ND 4b 47 45 50 4b 48 46 44 4b 52 55 54 48 51 4b 42 43 39 52 49 49 ND 40 54 4b 49 ND 38 44 48 47 51 43 47
47 4b 44 37 47 53 51 50 47 52 4 6 5 b 7 6 7 4 5 t9
33533b
ND 58 55 ND ND 54 57 40 58
356357
50 53 57 63 ND 23 53 ND 57
3 59360
44 48 ND ND ND 51 51 4b 47
55 64 ND 52 51 58 41 52 62 48 45 20 45 49 52
51 51 48 7 11 11
385386
56 49 49 ND 43 55 ND 46 55
387388
48 47 ND ND 51 49 53 37 62
412413
47 53 51 ND 62 6L 67 45 67
ND 54 62 ND ND 50 ND 49 52 ND ND 62 ND 49 49
50 50 5b* 5 6 8
*Signifleant ly different from controls by Dunnett1s test, P<0.05. ND * No data available.
SL 082118
TABLE A-5 (cont'd)
INDIVIDUAL AND MEAN DAILY WATER CONSUMPTION OF MALE RATS MAINTAINED FOR 731 DAYS ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE
Animal Numbers
3212-3 3214-5 3216-7 3218-9 3220-1 3222-3 3224-5 3226-7 3228-9 3230-1 3232-3 3234-5 3236-7 3238-9 3240-1 3242-3 3244-5 3246-7 3248-9 3532-4 3536-8 3540-2 3544-6 3548-50
41541b
ND 54 50 59 62
66
40 56
52 54 54 ND 50
MEAN iS.D.
54 7
440441
52 63 55
ND 54 65 47 69
ND 58 61 65 52
58 7
443444
51 52 53 ND 75 54 61 42 ND
33 52 72 5b 53
55 ill
468469
44 50 52 ND 61 51 70 43 55
69 ND 32 61 51
53 ill
471472
49 54 36 ND 63 53 73 40 56
ND ND ND ND
53 + 12
499500
56 58 64 48 55 5b ND 48 82
74 60
68
90 5b
63 + 13
503504
52 52 56 23 57 44 98 50 bO
73 74 60 99 56
61 + 20
Days on Test - 50 ppm Males
538539
541542
566567
569570
594595
50 50 52 52 68 69 52 55 54 54 72 68 79 73 60
59759S
76 54 ND
64 63 66 5b 75 70 61 55 74 50 79 22 ND ND ND 93 41 22 48 47 59 50 60 53 48 41 61 75 79 <-- 90 87 48 40 <-------
61 ND 84 94
90 98 93
83 76 ND 89 ND 98 78 81 50 48 82 86 72 72 bO 68 80 69 ND 54 45 69 62 72 64 76 88
67 63 60 bl 71 71 il4 + 14 110 + 16 + 14 27
622623
625626
83 81 59 59 62 73
--Dead-- ND 72
51 71
6b
57 <r~
79 ND
74 58 <-- 9b 69 92
82 b9
92 ND ND
66 77
69 76 14 9
650651
84 71 87
653654
86
54 87
68568 b
92 43 ND
688689
90 42 ND
716717
720 721
66 89 <--Dead-> ^--Dead-->
-Dead-
--Dead-
-Dead-
64 41 52 84 51 51
----- Dead-
-->
-Dead------
87 94 83
94 ND
-Dead------
ND 79 93 ND 48 bl
------- Dead------
-->
--Dead-
--Dead-
->
----- Dead---------
72
79 75
74 87
-Dead--
-Dead-
89 92
-Dead-
ND ND
97
<------Dead>
-Dead--
------------------ >
78 ND 71 ND
----- Dead^
79 76 76 73 67 79 9 20 20 21 + 19 19
ND No data available.
SL 082119
/f'
TABLE A-5 (cont'd)
INDIVIDUAL AND MEAN DAILY WATER CONSUMPTION OF MALE RATS MAINTAINED FOR 731 DAYS ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE
Animal Numbers
3174-5 3176-7 3178-9 3180-1 3182-3 3184-5 31B6-7 3188-9 3190-1 3192-3 3194-5 3196-7 3198-9 3200-1 3202-3 3204-5 3206-7 3208-9 3210-11 3512-4 3516-8 3520-2 3524-6 3528-30
MEAN +S.D.
104105
54 40 51 45 42 50 30 43 36
38 43 46 38 41
42 ib
107108
56 41 48 49 45 53 41 ND 35
39 44 31 44 42
44 7
139140
38 56 ND 55 41 54 47 45 45
42 50 35 47 43
4b ib
142143
56 42 47 53 45 4b 45 44 40
39 45 37 50 42
45 5
174175
55 47 54 56 45 ND 49 52 37
41 41 ND 51 38
49 11
177178
63 38 49 58 17 58 48 50 40
39 43 65 42 40
44 12
209210
5b 42 55 52 50 50 40 57 40
44 45 ND 5b 46
49 b
Days on Test - 100 ppm Males
212213
237238
240241
265266
268269
46 48 51 59 55 43 41 41 60 49 54 45 5b 64 63 44 54 ND ND ND 39 48 48 ND 51 45 43 47 57 63 42 48 46 48 54 53 44 57 ND 56 38 41 36 48 45
41 44 48 51 44 40 47 47 53 50 ND ND ND ND ND 45 49 49 57 57 35 44 34 60 54
43
47
47
56*
53
5 ib 7 ib ib
293294
58 55 ND bL 48 59 52 62 50
47 49 ND 56 ND
53 ib
296297
52 50 63 53 42 58 52 54 43
38 43 ND 52 ND
4b 12
331332
60 53 58 ND 44 51 57 ND 53
50 49 ND ND 43
52 6
335336
62 54 65 ND 49 53 22 ND 57
48 48 ND 59 41
51 12
356357
60 53 bl ND 50 40 50 49 ND
50 ND ND 53 49
51 ib
359360
58 bl 62 ND 51 ND 45 ND ND
49 42 ND 47 49
51 7
385386
59 50 62 ND 62 ND 59 ND 56
ND ND ND ND ND
58 4
387388
59 49 56 62 50 23 62 ND ND
43 34 ND 49 50
51 15
412 413
60 47 49 bb 51 31 55 56 ND
43 50 ND 54 37
50* 10
*Significantly different from controls by Dunnett's test, p<0.05. ND " No data available.
tn
c
o
CD
to
w
to o
TABLE A-5 (coat'd)
INDIVIDUAL AND MEAN DAILY WATER CONSUMPTION OF MALE RATS MAINTAINED FOR 731 DAYS ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE
Animal Numbets
3174-5 3176-7 3178-9 3180-1 3182-3 3184-5 3186-7 3188-9 3190-1 3192-3 3194-5 3196-7 3198-9 3200-1 3202-3
415416
63 54 NO ND 53 43 50
440441
NO 58 68 ND
1.9 67
443444
65 56 74 ND 67 66 53 75 66
468469
bO ND 75 ND 68 66 58 ND 69
471472
37 67 ND ND 64 74 55 ND ND
499500
69 71 66 ND 84 96 66 98 69
503504
63 68 89 ND 74 7b 59 90 58
Days on
538539
541 542
53 84 78 e-- 80 56 64 ND 54 78
61 84 81
81 51 64 ND 48 71 42
3206-7
3208-9
3210-11
3512-4 46 46 45 44 46 43 48 50 45
3516-8 52 47 54 64 57 60 57 64 67
3520-2 ND ND ND ND ND ND ND
3524-6 51 68 65 68 ND 80 83 55 55
3528-30
47
ND
48
38 48
7b
58
57
59
MEAN S,D.
53
62
fjl
61*
56
73* 69* 64
62
7 9 10 12 12 15 14 12 14
`Significantly different from controls by Dunnett'a test, p<0.05. ND = No data available.
100 ppm Males
/t)65t>7
569570
594595
74 57 64 98 94 65 ND 89 92
70 34 24 ND <r~ 71 67 76 97 86 73 58 53 63 74 72 92 48 53 50
4-------
64 87 59
54 56
ND 78
67 21
51 5b
8b 72
67 18
42 4b
68 70
68 15
597598
62 64 ND
74 ND ND 66 44
79 ND 67
622623
60 67 80
81 < 69 91 48
33 ND 57 73
625626
650651
653654
685686
688689
716717
720 721
69 ND ND 86 ND 2b 29
--Dead-
-Dead-
-De ad-
-- - ----Dead -
---------------- Dead -
94 ND 48 ND 81 ND 72
-Dead-
---------------->
57 ND 99 ND
90 73 ND
--Dead-->
47 <----
-Dead------------
53 ND ----------------Deal
64
61
58 --- -N-D--------6>2
21 ND ND 78 ND ND 85
92 ND ND <------------- --Dead----------------->
59 ND 68 63 ND 72 74
73 <-------
--Dead-------------------- -------?
ND 73 <---- ----------- Dt;ad---------->
ND 56 60 ND ND 60
43 49 54 20 62 65
*" 57 *-----74 73 74
59 65 68 17 16 22
ND 77 69 ND ND ND ND
-------Dead-------
-->
ND 65 79 ND 79 48
ND 65 ND 14
71 70 59 61 9 16 29 19
SL 082121
TABLE A-5 (rent'd)
INDIVIDUAL AND MEAN DAILY WATER CONSUMPTION OF MALE RATS MAINTAINED FOR 731 DAYS ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE
Animal Numbers
3136-7 3138-9 3140-1 3142-3 3144-5 3146-7 3148-9 3150-1 3152-3 3154-5 3156-7 3158-9 3160-1 3162-3 3164-5 3166-7 3168-9 3170-1 3172-3 3492-4 3496-8 3500-4 3506-8 3510
HEAH S.D.
104105
34 4b 36 43 45 47 39 41 43
41 54 48 34 23
41 8
107108
31 47 45 42 44 45 3b 37 4b
39 50 ND 41 20
40 8
139140
35 49 45 49 49 44 44 32 4b
49 58 48 45 28
4b 7
142143
36 4b 39 45 51 40 4b 44 43
49 52 49 42 23
43 7
174175
37 45 39 49 60 53 44 47 47
47 58 54 44 52
4b 19
177--178
43 49 37 49 48 47 48 4b 48
209--210
33 47 33 45 52 43 4b 43 49
Days on Test - 200 ppm Males
212--213
28 42 39 47 48 50 40 43 49
237--238
41 42 41 48 b2 47 41 48 43
240--241
37 4b 47 49 bO ND 51 52 47
2652bb
--
39 ND 43 bl ND 49 53 59 51
268269
--
38 45 50 53 63 42 50 ND 50
293--294
bl 51 41 58 ND 52 47 ND 52
296--297
38 51 39 47 ND 43 48 ND 47
331-
----3-3--2
37 4b 46 51 ND 46 48 ND 50
53 47 42 51 44 b0 58 47 51 53 5b 57 56 52 51 bl b4 59 b0 ND 54 51 4b 52 57 b2 56 ND 50 56 44 47 39 38 49 55 52 50 50 43 58 45 42 52 57 ND 59 53 57 58
47 4b 44 4b 50 54 52 49 4b 49 7 7 7 5 6 8 8 10 8 ib
33533b
38 ND ND ND 65 42 ND ND 57
59 59 55 ND ND
54 10
356357
38 50 45 4b ND 47 46 ND 49
b0 b3 ND 57 ND
50 8
359--3b0
37 49 44 47 ND 51 51 ND 41
53 50 ND 48 63
49 7
385386
ND 54 43 ND ND 55 39 50 57
ND ND ND ND ND
50 7
387388
49 48 39 51 ND 48 50 49 ND
51 50 bl 48 5b
50 5
412 413
29 47 39 47 63 36 47 ND 48
50 52 46 48 55
46* 9
*SlgnifIcantly different from controls by Dunnett's test, p<0.05 ND = No data available.
SL 082122
TABLE A-5 (ront'd)
INDIVIDUAL AND MEAN DAILY WATER CONSUMPTION OF MALE RATS MAINTAINED FOR 731 DAYS ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE
Animal Numbers
3136-7 3138-9 3140-1 3142-3 3144-5 3146-7 3148-9 3150-1 3152-3 3154-5 3156-7 3158-9 3160-1 3162-3 3166-5 3166-7 3168-9 3170-1 3172-3 3492-4 3496-8 3500-4 3506-8 3510
MEAN + S.D.
415416
42 m 45 55 HD 48 53 53 54
57 52 47 54 72
53 8
440441
56 ND 69 ND ND 53 ND 5b 49
65 50 36 35 38
51 12
443444
ND 52 42 58 55 50 48 52 55
5b 5b 34 64 45
51 8
468469
471472
499500
5b 50 54 59 43 26 65 63 <-- -- ------50 60 45 65 31 52 44 55
56 67 62 82
58 5b 88 62
6b 68 75 52 5b bO 32 59 65 71 bl 89 ND ND 92
51 56 70 13 11 13
503504
57 54 59 8b 68 62 88 58
64 52 62 9b 92
69 16
538539
72 63 52 86
54 67 64 ND 54
74 62 67 98 S3
69 14
541542
62 59 ND 7b
566567
53 63 58 8b
33 bb 58 b8 52 <--
41 70 87 b6 54
32
569570
67 b7 48 76
46 73 84 67 60
ND
594595
71 bl 56 81
91 66 9b 81 44
<
52
73 91 ND ND
60 56 55 57
84 65 67 71
91 < --
--
ND 93 ND 37
597598
622623
625626
650651
653654
685686
688689
716717
720 721
58 65 60 60 74 60 78 75 ------- Dead-----6b 57 60 59 88 86 ND 74 52 ND
74 68 60 80
67 94 ND 92 47
68 88 ND ND 62
ND 82 78 94 5b 61 7b 74 ND
------Dead ND ------
85 ND 76 ND ND 89
58 ND ^-- ------------ Dead-- -->
ND 68 72 66 96 66
81 46 <-- ------------ Dead-- ---->
ND 45 87 -----
44 20 41
92 73 78 51 66 59 < ---------- Dead--
-Dead-
73
52
>
ND 24 56 66 72 83
-Dead-
--
-Dead-
-Dead-
97 92
-Dead---------- >
ND 36 ND 97 --Dead--^
72 59 4-
-Dead------------->
<
69 48 54 ND 22
68 . ^ ad--
69 ->
--Dead-
89 40 6b 60 36 67
ND 99 ND ND ND ND
->
-Dead -
65 65 65 66 70 70 71 7b 49 67 70 68 71 15 19 12 18 13 12 14 17 25 15 12 20 12
ND = No data available.
SL 082123"
TABLE A-6
INDIVIDUAL AND MEAN DAILY WATER CONSUMPTION OF FEMALE RATS MAINTAINED FOR 730 DAYS ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE
Animal Numbers
3250-1 3252-3 3254-5 3256-7 3258-9 3260-1 3262-3 3264-5 3266-7 3268-9 3270-1 3272-3 3274-5 3276-7 3278-9 3280-1 3282-3 3284-5 3286-7 3288-9 3290-1 3292-3 3294-5 3296-7 3298-9 3300-1 3302-3 3304-5 3306-7 3308-9 3310-1 3312-3 3314-5 3316-7 3318-9 3552-4 3556-3 3560-2 3564-b 3568-70
MEAN +S.D.
104105
33 49 ND 48 43 ND 39 33 ND 41 43 29 36 33 28 38 35 36 35 35
47 44 42 41 3b
39 +6
107108
37 57 36 51 38 24 35 41 53 40 39 32 37 38 29 30 26 29 30 25
43 44 36 45 3b
39
8
139140
43 56 44 48 43 49 61 41 48 46 53 37 37 39 37 40 38 39 43 41
48 53 44 42 34
44 7
142143
47 61 47 50 39 46 67 42 47 39 48 35 49 37 41 41 44 41 39 48
52 53 47 51 37
46 7
174175
38 51 34 33 39 48 ND 38 46 34 47 35 42 40 33 40 38 38 41 18
50 47 45 44 54
41
+8
177178
4b 62 51 64 4b 62 75 42 44 41 49 32 48 41 33 39 42 41 50 55
53 59 44 5b 56
49
110
209-
210
39 52 54 ND 29 48 43 37 50 51 54 36 44 41 31 41 45 42 50 3b
50 52 43 40 39
44 7
Days on Test - Conttol
212213
237238
240241
265266
268269
42 38 50 51 49 49 50 ND 61 61 41 47 ND 59 63 52 55 bl 68 63 35 40 46 52 53 38 45 43 49 50' 45 42 57 52 72 25 38 48 41 46 40 40 43 52 55 46 44 45 55 5b 73 72 51 73 44 35 48 42 48 41 43 49 49 53 51 39 43 45 52 37 32 42 37 35 3b 40 41 44 51 37 39 41 ND 48 45 45 40 43 52 44 4b 48 51 64 56 36 20 23 ND 42
44 49 46 50 56 46 45 47 53 53 41 42 49 48 40 46 43 48 61 5b 36 41 42 46 43
42 44 46 53 50 9 9 7 8 9
293294
49 65 57 58 49 48 51 46 43 48 ND 44 43 48 39 43 49 42 53 44
48 56 ND 52 47
49
6
296297
39 62 47 57 45 45 46 72 45 50
68
30 33 34 31 46 44 39 39 37
38 16 ND 46 48
44
12
331332
43 ND 63 50 48 41 38 ND 47 45 72 46 48 46 33 43 42 40 42 57
38 55 38 58 46
47 9
335336
46 55 54 63 48 47 52 39 49 50 55 37 48 45 35 42 42 46 50 41
43 69 40 44 49
48
8
356357
47
66
51 bl 50 53 63 44 46 50 61 40 47 ND 42 46 48 49 ND ND
359360
48 50 52 53 38 42 58 43 44 48 ND 37 45 40 32 43 42 44 45 43
4b 37 56 , ND 52 ND 42 44 44 44
50 44 7 + 6
385386
42 45 54 60 43 54 54 46 50 47 47 41 38 50 ND 45 46 46 39 ND
ND ND ND ND ND
47
6
387388
47 50 51 69 47 60 54 41 52 50 4a 34 37 47 ND 49 50 42 45 51
42 50 25 50 47
47 8
412 413
50 67 57 27 63 64 55 64 63 60 51 48 52 49 46 52 47 42 55 58
50 57 49 56 47
53 9
ND * No data available.
jiz e o
Table A-6 (cont'd)
INDIVIDUAL AND MEAN DAILY WATER CONSUMPTION OF FEMALE RATS MAINTAINED FOR 730 DAYS ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE
Animal Numbers
3250-1 3252-3 3254-5 3256-7 3258-9 3260-1 3262-3 3264-5 3266-7 3268-9 3270-1 3272-3 3274-5 3276-7 3278-9 3280-1 3282-3 3284-5 3286-7 3288-9 3290-1 3292-3 3294-5 3296-7 3298-9 3300-1 3302-3 3304-5 3306-7 3308-9 3310-1 3312-3 3314-5 3316-7 3318-9 3552-4 3556-8 3560-2 3564-6 3568-70
MEAN S.D.
415416
46
66
51 11 57 63 53 48 52 50 54 42 48 47 35 49 49 49 50 50
50 56 41 48 41
48
10
440441
ND 61
9 69 53 56 47 64 53 59
66
42 50 56 43 ND 51 ND 55 52
55 71 ND 48 45
53 13
443444
50
66
64 72 ND 63 ND 72 29 58 59 43 61 48 39 54 44 ND 52 48
57 67
9 49 50
52 15
468469
50 64 41 52 68 59 49 69 44 55 ND ii 50
42 54 52 47 50 43
50 67 42 38 48
50
12
471472
48 65 44 42 68 60 44 ND 26 48 ND 37 52 49 40 62 52 40 50 ND
44 58 41 45 51
48
10
499500
63 50 50 72 76 58 55
4-
52 60 60 46 52 54 37 56 52 48 60 51 60
50
68
49 47 52
55 9
503504
56 37 54 67 61 64 55
44 61 ND
12
48 56 48 56 61 52 62 69 ND
60
66
50 48 47
54
12
Days on Teat - Control
538539
541542
566567
569570
594595
50 4b 48 46 45 61 ND 61 61 70 38 31 69 57 56 ND 76 ND 62 67 63 67 62 54 74 70 58 ND 58 60 61 55
54 53 47 49 58 70 80 73 74 82 64 76 92 76 71 53 44 51 48 4b 67 63 48 50 29 57 54 56 52 34
65 67 69 69 68 70 64 68 70 67
53 52 62 ND 54 44 45 50 47 58 69 75 18 65 ND 54 53 54 49 51 67 61 65 74 74
77 58
56 ND 52 48 60 73 67 70 63 65 57 53 52 50 70 48 48 40 44 24 54 50 59 47 63
58 58 59 59 58
9 12 14 11 14
597598
45
66
48
35 51
48 67 56 62 64 44
-Dead62 56
66 5b
65 49 48 32 25 50 54 54 50 52 61 55 49 50 42 52 71 ND 63 72 67
53 62
52 58
ND 68
55 61 41 5b 46 28
53 54
10 11
ND No data available.
32 59 66
-Dead53 48 65 62 56 59
62 53 76 53
86 63
45 52 61 61 57 ND 52 67 53 59 51
38 6b
74 ND ND 35 70 92
55 55 78 72
53 43
ND 59 60
63 56
86 <-----68 <-----
54 <----ND 51
685686
688-
689
-Dead------Dead--------
53 68 84
716717
72
720 721
66
40 70 44 ^--Dead--^
58 75 86 27 53
69 52 ND
- Dead--^
11 63 55 53 58
49 4------
-Dead-
60 31 27 19 Dead
62 ND 50 60 60
55 49 65 43 47
-Dead-
----------------- >
87 56 57 53 57
48 ND ND 57 ND
5b 60 62 68 ND
72 50 67 ^--Dead-->
-Dead -------------------- >
ND 57 48 <--Dead-^
91 ND ND ND ND
-Dead--
31 53 89 48 52
88 83 82 86 66
49 62 74 52 46
40 53 49 44 61
--Dead-
ND 71 65 56 62
61 58 92 66 63
56 51 75 ^--Dead--^
61 56 55 67
9 56 38 Dead
44 33 37 38
48 53 41 48
78 74 ^--Dead--^
59 67 ND ^--Dead-^
Dead--
------------------>
Dead-
Dead-
71 52 47 60 58
62 57 58 57 62 52
14 11 19 15 117 + 16
56 8
SL 082125
f
tn
C*
O CO to F-1
VO CSN
TABLE A-6 (cont'd)
INDIVIDUAL AND MEAN DAILY HATER CONSUMPTION OF FEMALE RATS MAINTAINED FOR 730 DAYS ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE
Animal Numbers
3398-9 34GO-1 3402-3 3404-5 3406-7 3408-9 3410-1 3412-3 3414-5 3416-7 3418-9 3420-1 3422-3 3424-5 3426-7 3428-9 3430-1 3432-3 3434-5 361264 361668 362062 362466 3628630
104105
29 36 ND 41 34 33 41 ND 38
41 44 44 35 34
107108,
32 38 41 40 35 54 21 38 44
42 50 42 52 35
139--140
42 43 36 40 3b 38 44 49 4b
142-
--143 40 45 38 43 39 33 3b 42 45
174--175
35 47 43 31 45 30 4b 44 ND
177--178
49 45 40 37 39 32 45 48 47
209-
--2'-1-0--
27 42 42
43 42 39 46 42 48
44 39 34 39 40 46 45 46 42 46 42 48 40 51 ND 38 38 43 43 36 30 35 36 35 34
Days on Test - 50 ppm
212--213
32 40 37 40 41 34 45 42 40
237238
3b 47 44 36 38 38 45 43 50
240241
60 !) 71 60 72 65 72 76 69
265266
42 45 43 40 45 35 52 38 50
268269
37 54 44 40 47 39 50 54 50
36 40 43 39 38 39 48 43 53 52 40 39 49 59 50 35 35 38 41 42 39 41 36 42 NO
MEAN S.D.
37 40 41 40 40 42 41 39 41 59* 45* 46 5 9 5 4 6 6 6 + 3 + 5 14 + 7 6
*Signlficantly different front controls by Dunnett's test, p<0.05. ND = No data available.
293294
40 45 40 45 ND 37 52 61 50
46 45 53 43 40
46 7
296297
31 2b 45 ND 42 37 41 4b ND
43 48 4b 38 38
40 7
331332
20 28 51 44 44 32 52 44 55
4b 40 44 40 39
41 9
33533b
48 46 45 37 47 34 50 47 54
48 46 56 40 42
46 6
356357
40 52 46 48 59 40 53 50 49
42 55 50 42 50
49 5
359360
31 47 44 48 51 26 47 41 48
40 52 46 36 39
43 8
385386
37 54 47 ND 46 35 50 46 49
ND ND ND ND ND
46 6
387388
3b 57 47 40 52 38 52 44 54
40 42 52 44 50
46 7
412 413
43 61 58 50 58 46 63 55 62
ND ND ND ND ND
55 7
TABLK A-b (cont'd)
INDIVIDUAL AND MEAN DAILY WATER CONSUMPTION OF FEMALL HATS MAINTAINED FOR 730 DAYS ON DRINKING WATER CONTAINING V1NYLIDENE CHLORIDE
Animal Numbers
3398-9 3400-1 3402-3 3404-5 3406-7 3408-9 3410-1 3412-3 3414-5 3416-7 3418-9 3420-1 3422-3 3424-5 342b-7 3428-9 3430-1 3432-3 3434-5 361264 361668 362042 362466 3628630
MEAN + S.D.
415416
47 89 ND 39 66 37 61 45 45
41 49 36 48 50
50 +15
440441
ND 61 52 ND 40 42 ND 30 52
44 49 50 54
H7 +9
443444
35 61 44 48 54 54 56 42 51
42 49 43 48
49 6
468469
35 52 30 40 51 39 54 41 5U
45 48 66 54 46 10
471472
40 50 40 44 49 42 52 44 58
37 53 59 52
48 +7
499500
41 55 49 ND 54 45 64 48 52
503504
38 60 54 41 47 44 60 42 50
40 ----
48 54
50 +7
44
52 54
49 +7
Days on 1; s[._- ::-b j jr.r.
538539
541542
566567
569570
46 42 ^8 ND
64 55 56 58
44 49 47 44
48 39 45 47
55 56 51 45
41 48 50 40
ND 76 75 68
50 43 51 60
62 68 62 56
58 56 50 ND
60 61
59 ND
594595
44 52 45 50 52 68 78 76 74 41 75
42 49 49 48 64
52 60 64 63 67 56 bl 22 65 54
52 55 52 54 60 8 + 10 + 12 + 10 + 13
597598
45 24 40 96 36 ND 61 45 ND 64 37
48
78 65
53 20
622623
41 ND 40 56 53 42 74 52 51 55 ND
625626
74 45 50 47 5b 51 52 53 66 64 ND
650651
37 53 48 14 52 53 57 46 74
92 46
46 46 ead-------
88
54 75 65 46 46 34
51 56 54 + 9 +11 21
653654
19 28 ND ND 46 68 73 55 76 41 57
90
25 52
53 22
685b86
ND 38 4b <: ' 50 55
<-- 78 67 70 457 91 51 39 53
<:-- 44 71
66 66
59 +15
688689
716717
720 721
47 <---Dead
45 --Dead-
45 42 49
-Dead-
55 48
40
78 42
50
------- Dead----- ->
-Dead-
-4*
84 62 62
ND 67 Dead
ND 54 62
-------Dead-------------- > 52 49 46 82 52 48
ND 44 50 38 32 34 54 64 61
-Dead52 79 73 71
-> 62
64
51 58 67 11 59 57
55 55 54 20 + 13 10
ND No data available.
SL 082127
I
TARLL A-6 (I'OHt'iiJ
INDIVIDUAL AND MLAN DAILY WATER CONSUMPTION OF FEMALE RATS MAINTAINED FOR 730 DAYS ON DRINKING WATER CONTAINING VINYU DENE CHLORIDE
An Inml Numbers
33bO-l 3362-3 3364-5 3366-7 3368-9 3370-1 3372-3 3374-5 3376-7 3378-9 3380-1 3382-3 3384-5 3386-7 3388-9 3390-1 3392-3 3394-5 3396-7 359264 359668 360062 360466 3608610
104105
NO 36 34 45 32 ND 45 51 12
44 31 36 33 44
107ioa
38 34 24 41 13 ND 41 43 30
39 38 38 38 39
139140
38 40 39 48 38 41 12 49 2b
39 39 42 33 4b
142143
40 37 33 44 35 41 4b 48 32
43 38 50 ND 39
174175
41 46 35 43 41 44 51 52 28
53 38 43 34 47
177178
4b 41 34 33 34 47 51 42 31
51 35 33 44 42
209--210
42 35 35 59 25 41 41 51 14
Days on Test - 100 pni
212-2---1---3-------
34 40 34 42 41 49 43 50 40
237--238
44 33 40 54 36 49 47 49 41
240--241
45 41 46 49 38 54 50 52 27
265--2bb
49 4b
48 63 41
ND 70 b7 21
268--269
54 63 50 56 49 69 b4 b2 52
51 38 4b 4b 50 52 35 42 4b 4b 4b 43 44 42 52 4b 51 43 4b 41 38 39 54 50 41 41 39 34 54 53
MEAN S.D.
37 37 38 40 43 40* 41 41 44 44 51 54 10 5 9 b 7 7 9 4 b 7 12 8
*Significantly different from controls by Dunnett's test, p<0.05. ND = No data available.
2932--94
ND 48 52 5b 43 53 ND 70 39
b0 41 4b 40 59
51 10
296297
ND 42 48 48 ND bl ND bO 32
48 39 44 38 47
4b 9
331332
38 44 45 49 42 52 ND bl 30
56 ND 37 58 56
47 10
335336
47 35 48 51 50 52 ND 64 31
60 42 43 43 55
48 9
356357
55 51 52 b0 46 60 ND bb 4L
62 53 49 48 b9
55 8
359160
54 4b 45 59 40 ND ND 63 29
ND 46 48 43 53
48 9
385386
55 42 48 60 37 54 ND 55 39
ND ND ND ND ND
49 9
387388
52 49 49 23 38 79 52 56 41
60 50 48 50 46
50 12
412 413
b 31 61 63 44 ND ND 73 47
7b 55 56 53 63
52 19
CO
tr*
o oo to H1 to
co
U'OlU 1 il )
INDIVI DUAL AND MIAN DAILY WA'i L K CONSUME i IU\ OJ E'EMALE RATS MAINTAINED 10R 730 DAYS ON IjR INKING WA'JER EON I'AIN INC V J NYU DEN!' CHLORIDE
OJ CO
SL 082139
An i rial N-u- m--ber--s
31 fall-1 33b2-3 33b4-5 33bb-7 1368-9 3370-1 3372-3 3374-5 3376-7 3378-9 3380-1 3382-3 3384-5 3386-7 3388-9 3390-1 3392-3 3394-5 3396-7 359244 359648 360042 360446 3608410
4154--1 fa
57 50 NO 61 46 71 80 62 44
62 58 46 47 59
MEAN S.D.
57
11
_ ____
5404-4 --1 -
ND 54 5b ND 38
87
61
78 31
443 --444
35 52 bl 60 15 59 57 70 42
_____
;63--469
54 47 59 60 48 76 67 ND 46
_ . ____ _________
.. - ____ Da^ys on Test
471 4--72
33
50 55
63
34 63 60 76 41
599--500
69 50 62 67 44 65 60 ?Q
46
503--504
60 54 62 71 5] 95 72
68
tl
5385--39
75 52
68
76 12
74
68
69
17
5h J 54-2---
58 52 64 81 42 ND 73 79 51
5665--67
ii
ND 80 45 98 65
66
45
] 00 p_p_rn_
56 9570_
394595
66 76 4-t 46 70 64 83 72 4 6 3b 86 ND 57 63 26 28 46 43
80 ND 72 40 80 73 78 76 74 78 7b
59 51 51 48 48 51 60 58 60 50 53
54 46 59 57 58 57 ND 59 56 60 67 54 52 58 50 56 57 62 60 56 56 55 51 26 72 58 72 69 83 74 78 82 75
55 50 59* 52 61 63 62 64 66 60 58 12 15 MO 12 12 13 19 1 2 1 5 18 16
5 7598
70 44 61 ND 72 44 51 52 57
69 51 bO 91 ND
b0 13
622621
80 45 59
4b ND 61 45 37
45 51 56 47 63
55 14
6 2 3626
75 47 65 85 54 9b 81 65 39
41 57 63 57 b5
64 16
6506 51
653654
45 42 57 38 60 67 46 44 99 ND 71 66
----
45 40 ND 60 44 40 ND 60
68568 b
688689
716717
720 721
Dead ----
ND ND ND 40
79 72 ND 68
ND 27 --Dead
50 79 69 ND
94 ND --Dead
83 82 --Dead
-Dead-
36 39 41 16
70 64 77 90
85 56 --Dead
54 38 ND 64
73 66 57 63
61 61 61 64
51 ND 38 5b
65 62 58 60
72 76 25
9
52 56 55 51
-- ____________ -- -Dead----64 ND 77 90 88 79 62 60 44 51 --Dead -- 55 64 72 66 67 7b 68 55 -- -- - -Dead
60 53 66 62 58 57 16 11 16 17 18 23
*Significantly di f terent f rom control s by Dunnett11 s lest, P<0.0S.
ND = No data available.
l'AUL.E A-6 (tout'd)
INDIVIDUAL AND MEAN DAILY WATER CONSUMPTION OF FEMALE RATS MAINTAINED FOR 730 DAYS ON DRINKING WATER CONTAINING VI NYU DENE CHLORIDE
Animal Numbers
3322-3 3324-5 332b-7 3328-9 3330-1 3332-3 3334-5 333b-7 3338-9 3340-1 3342-3 3344-5 3346-7 3348-9 3350-1 3352-3 3354-5 335b-7 3358-9 357244 357648 358042 358446 3588490
MEAN S.D.
104105
30 37 34 30 41 40 36 40 29
49 33 35 38 39
37 5
107108
31 43 40 37 4] 35 39 47 26
139140
27 45 37 35 41 43 53 50 38
44 43 33 3b 35 40 37 24 45 54
38 40 + 6 9
142143
29 39 34 43 42 38 51 43 32
45 31 33 49 44
40* 7
174175
29 48 38 37 47 42 42 52 13
49 37 34 41 43
41 +7
177178
25 46 37 40 39 40 45 48 34
48 37 34 28 50
39* 8
209210
31 4b 40 37 43 45 49 50 36
43 19 36 39 9
39 10
Days on Test
212213
237238
240241
33 38 27 41 49 <i3 27 33 38 39 9 48 41 48 42 41 45 47 52 43 40 49 45 64 34 37 40
200 ppm
265266
268269
49 35 46 49 46 47 45 44 51 51 49 53 54 37 61 56 45 18
293294
ND 53 42 44 47 51 41 60 36
40 41 43 53 49 45 32 36 40 47 ND 12 34 37 38 4b 40 40 3b 39 41 44 33 50 41 45 42 53 48 58
39 39 44 49 45 45 7 10 10 5 7 12
29b297
31 4b 42 48 38 4b 41 58 39
58 18 45 42 50
43 10
131332
31 51 31 38 37 46 48 62 43
43 33 44 50 53
44 9
335336
38 59 31 42 49 46 50 60 38
42 38 41 45 5b
45 9
356357
34 60 45 42 49 57 47 b4 44
ND 39 48 45 64
49 9
359360
31 49 37 5b 48 59 4b 53 40
ND ND ND ND ND
47 9
385386
36 43 39 43 47 57 50 73 40
ND ND ND ND ND
48 11
387388
36 52 39 46 47 49 44 50 31
412 413
51 55 54 48 64 44 25 ND 40
47 47 3b ND 42 45 48 58 57 60
45 49 7 10
*Signifleantly d i f f crent from control s by Dunnett1s test, p<0.05. ND = No data available.
SL 082130
TABLE A-6 (coat'd)
INDIVIDUAL AND MEAN DAILY WATER CONSUMPTION OF FEMALE RATS MAINTAINED FOR 730 DAYS ON DRINKING WATER CONTAINING VINYI.IDENE CHLORIDE
Animal Numbers
3322-3 3324-5 3326-7 3328-9 3330-1 3332-3 3334-5 3336-7 3338-9 3340-1 3342-3 3344-5 3346-7 3348-9 3350-1 3352-3 3354-5 3356-7 3358-9 35726,4 357648 358062 358466 3588690
415416
33 53 51 42 60 54 52 59 44
43 55 41 45 58
MEAN S.D.
49 8
440441
38 45 51 45 53 ND 55 67 45
41 50 43 8b 55
52 13
443444
34 44 50 43 55 59 50 62 32
48 47 47 45 54
48 8
468469
34 54 41 44 51 55 54 41 55
40 47 40 44 65
48 8
471472
38 75 35 45 53 55 4b 61 37
53 49 43 55 64
51 11
499500
44 51 45 51 62 72 54 62 44
52 63 40 60 68
55 10
503504
41 35 40 50 59 64 48 69 54
50 53 49 5b 60
52 9
Days on Test - 200 ppm
538539
541542
566567
569570
594595
54 4b 46 44 45
42 47 46 ND 44 53 48 55 51 57 55 7b 73 64 82 62 72 69 52 97 52 b4 59 51 52 74 67 64 59 68 47 50 44 48 47 72 62 ND 60 87
45 50 58 59 60 68 ND 53 49 30 50 67 71 75 25
55 59 5b 13 11 13
47 57 74 6L 49 46 58 67 66 37
56 60 9 18
597598
19
45 38 65 32 59 73 42 50
ND 53 50 79 53
51 16
622623
625626
41 42 -Dead-
44 45 56 57 74 83 58 54 51 53 74 78 41 47 5b 71
52 53 79 78 55 61 7b 58 51 61
58 60 13 13
6 50651
41
45 65 86 37 58
31 84
43 ND ND
52 ND 57 68 40
54 17
653654
26
685686
65
688689
85
71b717
67
720 7 21
58
96 49 48 51 47
--
-Dead
--------
59 95 89 70 72
41 --Dead------
5b 62 60 60 ND
-- -----Dead----
79 -Dead---- 83 27 73 89 ND
Dead
47 60 ND ND 40 46 75 77 ND 75 65 4b 52 36 40
-------- Dead-
---- --Dead-
32 48 35 ND
33 70 61 63
50 34 --Dead
91 63 68 58 58
91 ----------- Dead-----------
61 44 35 46 ND
69 b8 83 61 ND
31 84 52
63 57 62 58 57 22 19 18 16 13
ND - No data available.
SL 082131
TABLE A-7
Dose Level Animal __ Number HDoanyes nonn 'tTeasrt*t-:.
0 74-3066 3067 3060 3069 3070 3071 3072 3073 3080 3085 3086 3093 3095 3100 3102 3104
mean+sd
50 74-3212 3213 3214 3215 3216 3217 3218 3219 3221 3227 3232 3236 3237 3247 3540
MEAN+SD
_____, l1O81t
NDa 50 ND 53 48 ND 49 53 ND ND ND ND ND ND ND ND
50+2
ND ND 52 ND 50 ND 51 55 51 ND ND ND ND ND ND
52+2
INDIVIDUAL AND MEAN HEMATOLOGIC VALUES FOR MALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINTLIDENE CHLORIDE FOR 731 DAYS
FCV Percent
13K6C5
C54A0n
-I7XX011
53 50 50 ND 43 52 ND ND ND ND ND ND ND ND ND ND
504
51 48 45 ND 44 47 ND ND ND ND ND ND ND ND ND ND
47+3
45 ND ND 44 HD ND ND ND 50 38 38 40 42 50 49 52
45+5
53 52 ND 54 ND 53 50 ND ND ND ND ND ND ND ND
52+2
51 48 ND 51 ND 47 ND ND 48 ND ND ND ND ND ND
49+2
47 35 ND ND ND 47 ND ND ND 45 42 43 51 48 40
44+5
___________ x1n8i1
ND 8.82
ND 9.70 9.3?
ND 8.97 9.14
ND ND ND ND ND ND ND ND
9.2010.35
RBC x IQ6/TM3
-3L r6r5-
.5.40
8.07 8.25 8.03
ND 7.22 7.76
ND ND ND ND ND ND ND ND HD ND
8.36 7.80 6.83
ND 6.58 7.05
ND ND ND ND ND ND ND ND ND ND
7.8710,40 7. 32+0. 74
---------------------------T""~
701 181
7.22 ND ND
?. 10 ND ND ND ND
9.18 6.92 6. 51 6. 22 7.10 7,75 7.55 7. 97
ND 16.2
ND 17.3 17.2
ND 16,6 17.1
ND ND ND I ND ND ND ND
7.35+0, 83 16.9+0.5
Hgb K/iOO ml
~
365
1.
540
-----------------------------
701
15.5 16.3 15.9
ND 14.4 16.3
ND ND ND ND ND ND ND ND ND ND
16.1 16.0 14,2
ND 13.8 14 .8
ND ND ND ND ND ND ND ND ND ND
13.6 ND ND
14.3 ND ND ND ND
16.1 12.6 12 .6 12.6 14.5 16.1 15.5 16.1
15.7+0.8 14.9+1.0 14.4+1.5
WBC x 103/TM3
--------------------------------------------------------*
181 365
540
ND 11.6
ND 11.6 15.3
ND 9.5 12.7
ND ND ND ND m ND ND ND
14.6 14.6 14.1
ND 17.7 15.1
ND ND ND ND ND ND ND ND ND ND
9.8 12.1 11,5
ND 17.7 15,7
ND ND ND ND ND ND ND ND ND ND
12.1+2.1 15.2+1.4 13.4+3.2
701
25. 3 ND ND
11.1 ND ND ND ND
16.3 18.3 17.9 21.7 10.3
9.3 14.4 13.4
15.8+5.1
ND ND 8.78 ND 8.82 ND 8. 58 9.37 9.15 ND ND ND ND ND ND
8.941:0.32
8. 52 8. 73
ND 9. 27
ND 8.11 7.93
ND ND ND ND ND ND ND ND
8.51+0.53
8.73 7.43
ND 8. 53
ND 7.64
ND ND 7.05 ND ND ND ND ND ND
7.88+0. 72
7. 72 5.74
ND ND ND 7.42 ND ND ND 1.22 6.67 7.02 8.08 8.12 6.12
7.12+0. 83
ND ND 17.4 ND 18.4 ND 15.9 18.1 17.8 ND ND ND ND ND ND
16.0 16.5
ND 17.3
ND 16.1 16.0
ND ND ND ND ND ND ND ND
17.5+1.0 16,40,6
17.1 15.4
ND 16.9
ND 15.7
ND ND 14.3 ND ND ND ND ND ND
15.9+1.1
15.5 12.2
ND ND ND 15.4 ND ND ND 15.6 14.0 14.4 17.0 16.1 14.0
14,9+1.4
ND ND 14 .8 ND 18.9 ND 15.9 19.6 13.7 ND ND ND ND ND ND
12.6 12.6
ND 18.7
ND 14.7 23.7
ND ND ND ND ND ND ND ND
16.6+2.6* 16.5+4.8
12,4 16.4
ND 13.2
ND 13.3
ND ND 13.1 ND ND ND ND ND ND
13.711.6
16. 7 18.1
ND ND ND 16.9 ND ND ND 12.4 12,1 21.2 11.6 20.4 12.9
15.8+3.7
SL 082132
ND * no data available. Significantly different frn^i control mean by Dunnett's test* p<0.G5.
TABLE A-7 (cont'd)
Dose Level Animal
ppm Number Days on Test:
0 74-3066 3067 3068 3069 3070 3071 3072 3073 3080
?J
J3 3095 3100 3102 3104
MEAN
50 74-3212 3213 3214 1215 1b 3217 3218 3219 3221 3227 3232 3236 3237 3247
INDIVIDUAL AND MEAN HEMATOLOGIC VALUES FOR MALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 731 DAYS
Neutrophils 181 365 540 701
ND 12 18 50 8 8 13 ND
ND 10 13 ND 11 ND ND 25 46 23 26 ND ND 18 20 ND 14 ND ND ND 11 ND ND ND ND ND ND 31 ND ND ND 18 ND ND ND 30 ND ND ND 57 ND ND ND 52 ND ND ND 23 ND ND ND 35 ND ND ND 27
18 14 18 35
ND 18 9 42 ND 13 83 44 19 ND ND ND ND 26 10 ND 15 ND ND ND ND 20 22 42
8 33 ND ND 21 ND ND pro 14 ND 27 ND ND NO ND 20 ND ND ND 26 ND ND ND 31 ND ND ND 29 ND ND ND 40 ND ND ND 32
15 22 30 34
Lymphocy tes__ 181 365 540 701
ND 78 79 41 88 81 79 ND ND 84 82 ND 84 ND ND 68 51 73 66 ND ND 79 75 ND 79 ND ND ND 83 ND ND ND ND ND ND 63 ND ND ND 74 ND ND ND 61 ND ND ND 35 ND ND ND 46 ND ND ND 70 ND ND ND 60 ND ND ND 67
77 79 76 58
ND 77 83 53 ND 86 14 49 74 ND ND ND ND 74 84 ND 81 ND ND ND ND 75 70 52 86 64 ND ND 74 ND ND ND 82 ND 68 ND ND NO ND 70 ND ND ND 68 ND ND ND 62 ND ND ND 63 ND ND ND 56 ND ND ND 59
79 75 64 59
Monocytes
181 365 540 701
ND 9 3 10
15 5 ND
ND 3 5 ND 4 ND NB 4 2 3 7 ND
ND l 3 ND 5 ND HD ND
6 ND ND ND ND ND ND 4
ND ND ND ND ND ND ND ND ND ND ND ND ND HD ND ND ND ND
7 9 7 2 4 4
ND ND ND 5
4 54 5
ND 2 6 5 ND 0 2 6
3 ND ND ND ND 0 4 ND
3 ND ND ND ND i 6 3
5 3 ND ND 4 ND ND ND 4 ND 4 ND ND ND ND 9 ND ND ND 5 ND ND ND 5 ND ND ND 5 ND ND ND 2 ND ND ND 8
4 145
EoslnophiJs
181 365 540 701
ND 7 2 4
J 1 j ND
ND 2 0 ND
i ND ND 3 ] ] 7 ND
1 2 ND
ND ND ND
ND ND W) ND ND l
>ID ND [Xi n ND
i 0
Nf ND 1
ND LtiJ ND 0
pro ND ND 3
ND ND ND 1
ND ND ND 1
i 12 2
ND 3 2 0 ND 1 1 1
4 ND ND ND ND 0 2 ND
1 ND ND ND ND 4 2 3
I 0 ND pro i ND ND ND 0 ND 1 ND ND ND ND i ND ND ND 1 ND ND ND 2 ND ND ND 3 ND ND ND 2 ND ND ND I
1 22 2
Basophils 181 365 540 701 ND 0 0 0
0 0 0 ND ND 1 0 ND
0 ND ND 0 0 0 0 ND ND 0 0 ND 0 ND ND ND 0 ND ND ND ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0
0 00 0
ND 0 0 0 ND 0 0 0
0 ND ND ND ND 0 0 ND
0 ND ND ND 0 ND 0 0 0 0 ND ND ND 0 ND ND 0 ND 0 ND ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0
0 0 00
ND = No data available.
TABLE A-7 (cont'd)
Dose
Level Animal PPm Number
Days on Test:
100
74-3175 3176 3177 3179 3180 3182 3183 3184 3186 3187 3191 3195 3199 3202 3209 3208 3512
MEAN+SD
200 74-3137 3139 ^140 3141 3142 3143 3144 3147 3148 3154 3171 3496 3498 3500
MEANlSD
INDIVIDUAL AND MEAN HEMATOLOGIC VALUES FOR MALE RATS MAINTAINED ON DRINKING HATER CONTAINING V1NYLIDENE CHLORIDE FOR 731 DAYS
J 31
54 ND 50 50 54 ND 59 ND ND ND ND ND ND ND ND ND
5 3*4
PCV Percent 365 540
701
57 48 ND ND ND 48 52 50 ND ND ND ND ND ND ND ND ND
51+4
51 49 ND ND ND 46 39 57 ND ND ND NI> ND ND ND ND ND
48+7
48 ND ND ND ND ND ND ND 46 45 49 46 42 5J 51 46 45
47+3
ND 58 52 54 55 ND 51 ND ND ND ND ND ND ND
54 3
50 51 53 53 ND 57 ND ND ND ND ND ND ND ND
53 + 3
53 50 47 52 ND 44 ND ND ND ND ND ND ND ND
4 9 4
50 ND hb 51 ND ND ND 49 4f 46 48 48 44 41
W+3
RBC x 10 /ram 181 365 540 701
9.61 ND
0.77 9,00 9.69
ND 10,13
ND ND ND ND ND ND ND ND ND ND
9.44+0.55
9.89 8. 37
ND ND ND 7.63 8.31 8.17 ND ND ND ND ND ND ND ND ND
8.47+0.84
8.44 7.72
ND ND ND 7. 28 6.72 7.33 ND ND ND ND ND ND ND ND ND
7.49+0. 64
7.93 ND NO ND ND ND ND ND
7. 53 7.15 7.71 7, !0 6.8y 8.17 8.66 7.68 6. 73
7.62+0. 58
ND 1 0. 13
9.18 r'.26 9.90
ND 8.77
ND ND ND ND ND ND ND
9.45+0. 56
8.07 8. 17 3. 53 8.34
ND 9. 50
ND ND ND ND ND ND ND ND
8.52+0.57
8.42 7. 64 7.87 8.75
ND 7.59
ND ND ND ND ND ND ND ND
8.05+0. 51
7.85 ND
7. 76 7 .91
ND ND ND 7.47 7.99 7.55 7.81 7. 79 7.60 6.40
7.61+0.46
Heb g/100 nil 181 365 540 701
18.1 ND
16,8 16.4 18.2
ND 19.3
ND ND Nl) ND ND ND ND ND ND ND
17.8+1.2
18.1 15.7
ND ND ND 15.4 15.9 16,2 ND ND ND ND ND ND ND ND ND
16.5+1.1
15.9 14.7
ND ND ND 14.9 J 2.8 17.8 ND ND ND ND ND ND ND ND ND
15.2+1.8
15.5 ND ND ND ND ND ND ND
15.2 14.7 15.9 14.6 14.4 16.4 16.4 15.0 14.9
15.3+0.7
ND 19.5 17.1 17.7 18.2
ND 16.8
ND ND ND ND ND ND ND
17.9+1.1
15.3 16.6 16.4 16.4
ND 18.7
ND ND ND ND ND ND ND ND
16.7+1.2
16.1 16.1 L5.3 16.6
ND 14.8
ND ND ND ND ND ND ND ND
15.810.7
15.3 ND
15.1 15.6
ND ND ND 15.9 15.0 15.2 15.4 15.6 15.4 13.1
15.2+0.8
WBC x 10 /mm 181 365 540 701
12.6 ND
11.6 11.6 11.5
ND 11 .6
ND ND ND ND ND ND ND ND ND ND
11.8+0.5
17.2 14.2
ND ND ND 20.5 14.7 25.7 ND ND ND ND ND ND ND ND ND
18.5+4.8
12.7 18,0
ND ND ND 21.8 19.1 23.8 ND ND ND ND ND ND ND ND ND
24.2 ND ND ND ND ND ND ND
16.2 11.4 15.8 25.7 25.5 13.5 25.2 16.2 10.7
19.1+4.2* 18.4+6.1
ND 15.5 13.9 15.4 17.9
ND 10.6
ND ND ND ND ND ND ND
14.7+2.7
36.4 16.0 18.9 18.7
ND 16.4
ND ND ND ND ND ND ND ND
21.3+8.6
17 .8 is:6 15.0 15.8
ND 23.2
ND ND ND ND ND ND ND ND
16.6 ND
13.0 16.4
ND ND ND 20.2 17.5 16. 3 18.6 14.0 19.2 20.1
17.5+3 .4 17.2+2.4
SL 082134
ND * No data available.
TABLF A-7 (cont'd)
Dose Level Anima 1
PPm Number Days on Test:
100 74-3175 3176 3177 3179 3180 3182 3183 3184 3186 3187 3191 3195 3199 3202 3 209 3208 3512
MEAN
200 74-3137 3139 3140 314] 314 2 3143 3144 314 7 3148 1154 3171 3496 3498 3500
MEAN
INDIVIDUAL AND HE AH HEMATOLOGIC VALUES FOR MALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 731 DAYS
r, - <rophi Is 181 365 540 701
9 18 9 29 ND 11 25 ND 17 ND ND ND 10 ND ND ND 20 ND ND ND ND 35 31 ND 26 32 32 ND ND 60 56 ND ND ND ND 24 ND ND ND 37 ND ND ND 50 ND ND ND 39 ND HD ND 28 ND ND ND 45 ND ND ND 47 ND ND ND 46 ND ND ND 54
16 33 31 40
ND 67 14 25 18 10 19 ND
8 23 18 25 28 29 14 41
9 ND ND ND ND 19 33 ND 16 ND ND ND ND ND ND 22 ND ND ND 30 ND ND ND 26 ND ND ND 36 ND ND ND 31 ND ND ND 41 ND ND ND 36
16 29 20 31
Lymphoey te:s 181 365 540 701
84 80 81 66 ND 70 69 ND 76 ND ND ND 85 ND ND ND 76 ND ND ND ND 58 59 ND 71 64 58 ND ND 37 39 ND ND ND ND 68 ND ND ND 59 ND ND ND 44 ND ND ND 54 ND ND ND 65 ND ND ND 48 ND ND ND 49 ND ND ND 48 ND ND ND 43
78 62 61 54
ND 29 83 72 82 82 75 ND 88 74 80 71 66 63 82 56 82 ND ND ND ND 72 58 ND 76 ND ND ND ND ND ND 76 ND ND ND 64 ND ND ND 71 ND ND ND 62 ND ND ND 65 ND ND ND 53 ND ND ND 51
78 64 76 64
Monoi; vtes 181 365 540 7_0i
518 ND 6 4
5 ND ND 5 ND ND 2 ND ND ND 6 5 2 3 10 ND 3 5 ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND
5 ND ND ND ND ND ND ND
6 2 5 5 7 6 4 5 3
4465
ND 4 3 3 8 5 3 ND 3 204 44 4 3 8 ND ND ND
ND 4 6 ND 4 ND ND ND
ND ND ND i ND ND ND 4 ND ND ND 1 ND ND ND 1 ND ND ND 2 ND ND ND 6 ND ND ND 11
54 34
LosinophiIs 181 365 540 700
, 2o ND ) 2 ND
2 ND ND ND 0 ND ND ND 1 ND ND ND ND J 5 ND 1 1 0 ND ND 0 0 ND ND ND ND 2 ND ND ND 2 ND ND ND 1 ND ND ND 2 ND ND ND 0 ND ND ND 1 ND ND ND 0 ND ND ND 1 ND ND ND 0
2i21
ND 0 0 0 2 3 3 ND 1 1 20 24 00 0 ND ND ND
ND 5 3 ND 4 ND ND ND
ND ND ND 1 ND ND ND 1 ND ND ND 2 ND ND ND 1 ND ND ND 2 ND ND ND 0 ND ND ND 2
132J
ND = No data available.
Baso phi 1:S 181 365 540 701
o oo
ND 0 0 ND
0 ND ND ND 0 ND ND ND ] ND ND ND
ND 0 0 ND
0 0 0 ND
ND 0 0 ND ND ND ND 0
ND ND HD 0
ND ND ND ND ND ND ND ND ND
0 0 0
ND ND ND 0
ND ND ND ND ND ND
0 0
ND ND ND 0
0 000
ND 0 0 0 o 0 0 ND oo00 o000 1 ND ND ND
ND 0 0 ND 0 ND ND ND
ND ND ND 0 ND ND ND 1 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0
0 0 00
SL 082135
TABLE A-fl
Dose Level AdInal
pp Nutobe r Days on Test:
0 74-3250 3252 3253 3254 3255 3257 3260 3267 3271 3272 3279 3280 3288 3291 3304
MEAN+SD
SO 74-3398 3399 3400 3401 3402 3404 3406 3408 3414 3415 3416 3418 3423
MEANtSD
INDIVIDUAL AND KEAN HEMATOLOGIC VALUES FOR FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 730 DAYS
182
50 49 53 54 44 ND ND ND ND ND ND ND ND ND ND
50+4
46 53 ND 51 48 51 ND ND ND ND ND ND ND
50*3
PCV Percent 365 540
50 43 46 ND 53 48 49 37 46 45 ND 43 ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND
49+3 43+4
702
ND ND ND ND 41 ND 39 49 46 45 44 46 42 52 40
444
48 49 45 49 51 ND ND ND ND ND ND ND ND
48+2
45 51 47 39 44 ND ND ND ND ND ND ND ND
45+4
ND 36 37 ND 47 ND 49 46 44 44 50 48 46
45i5
182
8.15 8.23 8.67 9.25 7.95
ND ND ND ND ND ND ND ND ND ND
8.45Q.52
RBC x lQ^/mm^ 365 540 ""
702
7.73 7.75 7.85 8.07 7.49
ND ND ND ND ND ND ND ND ND ND
6.03 ND
7.05 6.06 7.36 6.46
ND ND ND ND ND ND ND ND ND
ND ND ND ND 6.40 ND 6.64 7.59 7. 71 6.66 6.81 7.07 6.57 7.92 5.94
7.78+0.21 6.59+0.59 6.93+0.63
7.73 8.86
ND 8.70 8. 56 8.44
ND ND ND ND ND ND ND
8.32+0.45
7.49 7.79 6.98 8.20 8.42
ND ND ND ND ND ND ND ND
7.78+0.57
7.26 8.07 6.83 6.73 7.59
ND ND ND ND ND ND ND ND
7.29+0.55
ND 5.02 4.65
ND 7.36
ND 7.53 7.81 6.74 6.66 7.76 7.83 7.05
6.84+1.14
182
15.8 15.7 17.0 17.5 14.8
ND ND ND ND ND ND ND ND ND ND
16.2+1.1
Hgb a.7100 ml 365 "540 `
15.8 15.3 16.1 15.8 14 .2
ND ND ND ND ND ND ND ND ND ND
13.0 ND
15 .2 12. n 14.5 13.9 ND ND ND ND ND ND ND ND ND
15.4+0.8 13.7+1.3
" 702
ND ND ND ND 13.3 ND 14.3 15.7 15.9 14.9 13.5 14.4 13.4 16.7 13.3
14.5+1.2
15.4 17.3
ND 16.6 16.6 16.7
ND ND ND ND ND ND ND
16.5+0.7
15.4 15.6 14.5 16.2 16.3
ND ND ND ND ND ND ND ND
15.6+0.7
15.2 17.2 14.9 15.1 15.0
ND ND ND ND ND ND ND ND
ND 12.1 11.4
ND 14.6
ND 16.1 15.9 14.2 14.9 15 .4 15.8 15.0
15.5+1.0* 14.5+1.6
WBC X 103/b3 182 365 540 702
9.6 9.6 10.7 11.0 8.0 ND ND ND ND ND ND ND ND ND ND
12.6
11.0 14.5
10.1
7.3 ND ND ND ND ND ND ND ND ND ND
10.0 ND
10.2 16.6
6.7 10.1
ND ND ND ND ND ND ND ND ND
ND ND ND ND 5.4 ND 12.7 7,3 6.3 12,3 21.2 12.4 12.3 7.7 9.9
9.8+1.2 11.1+2.7 10.713.6 10.814.6
9.4 10.3
ND 11.2 10.8 11.9
ND ND ND ND ND ND ND
11.5 8.2 9.2 9.9
13.0 ND ND ND ND ND ND ND ND
10.7+0.9 10.4+1.9
10.0 8.3
10.2 7,4 8.5 ND ND ND ND ND ND ND ND
8.9+1.2
ND 8.2 8.4
ND 12.6
ND 10.8
7.5 15.6
8.9 13.5 13.0
7.2
10.6+2.9
ND No data available. *
Significantly different from control mean by Dunnett's test. p<0.05
cn
tr*
082136
TABLE A-8 (cont'd)
Dose Level Animal
ppm Number Days ion Test:
0 74-3250 3252 3253 3254 3255 3257 3260 3267 3271 3272 3279 3280 3288 3291 3304
MEAN
50 74-3398 3399 3400 3401 3402 3404 3406 3408 3414 3415 3416 3418 3423
MEAN
INDIVIDUAL AND MEAN HEMATOLOGIC VALUES FOR FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 730 DAYS
Neutrophil s 182 365 540 702
10 11 26 ND 11 9 ND ND 23 18 22 ND 11 8 51 ND 13 12 13 45 ND ND 24 ND ND ND ND 38 ND ND ND 20 ND ND ND 44 ND ND ND 35 ND ND ND 59 ND ND HD 59 ND ND ND 46 ND ND ND 52 ND ND ND 36
14 12 27 43
31 27 24 ND 12 18 13 27 ND 10 8 34 14 14 19 ND 15 11 23 45
8 ND ND ND ND ND ND 26 ND ND ND 21 ND ND ND 44 ND ND ND 37 ND ND HD 27 ND ND ND 48 ND ND ND 31
16 16 17 34
Lymphocytes 182 365 540 702
85 83 68 NU 88 86 ND ND 71 80 72 ND 81 86 40 ND 83 85 80 48 N Li ND 67 ND ND ND ND 56 ND ND ND 72 ND ND ND 49 ND ND ND 60 ND ND ND 32 ND ND ND 35 ND ND ND 49 ND ND ND 44 ND ND ND 53
82 84 65 50
64 67 69 ND 80 78 83 70 ND 85 90 64 81 82 78 ND 80 89 72 48 88 ND ND ND ND ND ND 64 ND ND ND 74 ND ND ND 50 ND ND ND 56 ND ND ND 65 ND ND ND 49 ND ND ND 66
79 80 78 61
Monocytes 182 365 540 702
4 3 5 ND 1 3 ND ND 1 I 4 ND 6 3 3 NO 4 24 7 ND ND 3 ND ND ND ND 5 ND ND ND 1 ND ND ND 4 ND ND ND 4 ND ND ND 7 ND ND ND 6 ND ND ND 3 ND ND ND 4 ND ND ND 8
3 24 6
3 2 3 ND 614 2 ND 3 1 1 4 2 2 ND 5 03 5 2 ND ND ND ND ND ND 9 ND ND ND 4 ND ND ND 4 ND ND ND 6 ND ND ND 7 ND ND ND 3 ND ND ND 2
4 2 34
Eosinophils 182 365 540 702
l 3 1 ND 0 2 ND ND 5 1 2 ND 2 2 6 ND 0J 3 0 ND ND 6 ND ND ND ND 1 ND ND ND 1 ND ND ND 3 ND ND ND 1 ND ND ND 2 ND ND ND 0 ND ND ND 2 ND ND ND 0 ND ND ND 3
224 1
1 4 4 ND 2 20i ND 2 1 i 1 2 1 ND 0022 2 ND ND ND ND ND ND 1 ND ND ND 1 ND ND ND 2 ND ND ND 1 ND ND ND 1 ND ND ND 0 ND ND ND 1
1221
Basophils 182 365 540 702
0 0 0 ND 0 0 ND ND 0 0 0 ND 0 1 0 ND 0000 ND ND 0 tro ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0
0000
1 0 0 ND 0 100 ND 0 0 0 0 0 0 ND 0000 0 ND ND ND ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0
0 000
ND No data available.
c/a
tr1
111 0: ^
TABLE A-8 (cont'd)
INDIVIDUAL AND MEAN HEMATOLOGIC VALUES FOR FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 730 DAYS
Dose Level Animal
ppm Number Days on Teat:
100
74-3360 3361 3362 3363 3365 3366 3368 3373 3376 3377 3379 3381 3387 3388 3393 3394
HEANtSD
182
45 54 ND 53 51 50 ND ND ND ND ND ND ND ND ND ND
50+3
PCV Percent 365 540
47 54 47 ND ND 50 47 ND ND ND ND ND ND ND ND ND
49+3
48 49 48 ND ND 49 48 ND ND ND ND ND ND ND ND ND
4B1
702
ND ND 44 ND ND ND ND 36 44 44 47 52 47 43 42 45
44+4
RBC x 106/m3 182 365 540 702
7.52 B. 70
ND 8.75 8.13 7.93
ND ND ND ND ND ND ND ND ND ND
8..21+0.52
7.83 8.46 7.55
ND ND 7.90 7.46 ND ND ND ND ND ND ND ND ND
7.84+0.39
7.28 7.04 8.10
ND ND 7. 02 7.11 ND ND ND ND ND ND ND ND ND
7.31+0.45
ND ND 7.48 ND ND ND ND 5.01 6.54 6.68 6.96 8.30 7.30 6.50 6,27 7.46
6.85+0.89
Hgb ft/100 ml 182 365 540 702
14.5 17.5
ND 17.0 16.0 16.2
ND ND ND ND ND ND ND ND ND ND
16.2+1.1
15.4 17.6 14.6
ND ND 16.7 14.7 ND ND ND ND ND ND ND ND ND
15.8+1.3
14.8 14.8 15.7
ND ND 16.5 15.1 ND ND HD ND ND ND ND ND ND
15.410.7
ND ND 14.7 ND ND ND ND 12.1 13.9 14.1 14.6 16.2 15.0 13.6 14.2 14.1
14.3+1.0
200
74-3322 3323 3324 3325 3326 3327 3328 3329 3331 3334 3340 3346 3348 3355 3356 3580
MEANSSD
47 47 ND 47 49 ND 56 ND ND ND ND ND ND ND ND ND
494
48 50 47 50 52 ND HD ND ND ND ND ND ND ND ND ND
49+2
46 49 ND ND 41 ND 39 43 ND ND ND ND ND ND ND ND
44+4
48 ND ND ND ND 50 ND ND 42 50 49 43 46 46 41 48
46+3
7.80 8.10
ND 7.22 8.10
ND 8.85
ND ND ND ND ND ND ND ND ND
8 .01+0.59
7.36 8.10 8.00 7.23 7.68
ND ND ND ND ND ND ND ND ND ND ND
7.67+0.38
7.43 7.65
ND ND 5.81 ND 5.90 6.89 ND ND ND ND ND ND ND ND
6.74+0.85
7.23 ND ND ND ND
7.61 ND ND
6.39 7.68 8.17 6.73 6.80 6.81 5.85 7.76
7.12+0.73
15.4 15.3
ND 15.1 16.2
ND 17 .6
ND ND ND ND m W ND to ND
15.9+1.0
15.3 15.9 16.1 16.1 16.1
ND ND ND ND ND ND ND ND ND ND ND
15.9+0,3
15.3 15.0
ND ND 13.1 ND 12.7 14.4 ND ND ND ND ND ND ND ND
14.1+1.2
14.9 ND ND ND ND
15.7 ND ND
13.9 16.1 16.1 13.6 14.8 14.5 12.4 16.1
14.8+1.2
ND " no data available.
WBC j, io3/TM3
182 365
540
14.5 9.9 ND
12.0 12.5 10.1
ND ND ND ND ND ND ND ND ND ND
11.4 10.5 10.6
ND ND 12.1 20.1 ND ND ND ND ND ND ND HD ND
17.8 13.3
5.0 ND ND 13.4 10.2 ND ND ND ND ND ND ND ND ND
11.8+1. 9 12.9+4. 1 11.9+4.7
11.7 12.0
ND 10.9 11.3
ND 11.1
ND ND ND ND ND ND ND ND ND
11.4+0. 4
12.0 10.6
8.2 8.6 9.7 ND ND HD ND ND ND ND ND ND ND ND
9.8+1. 5
10.5 8.6 ND ND
17 .8 ND
11.5 10.1
ND ND ND ND ND ND ND ND
11.7+3.6
702
ND ND 6.2 ND ND ND ND 13.7 8.8 9.7 12.2 6.6 8.3 6.4 10.5 9.8
9.2+2
7.9 ND ND ND ND
6.4 ND ND
7.1 6.1 6.3 9.7 12.2 6.6 6.0 4.8
7 .3+2
SL 082138
Dose Level Animal
ppm Number Days on Test:
100 74-3360 3361 3362 3363 3365 3366 3368 3373 3376 3377 3379 3381 3387 3388 3393 3394
MEAN
100 74-3322 3323 3324 3325 3326 3327 3328 3329 3331 3334 3340 3346 3348 3355 3356 3580
MEAN
INDIVIDUAL AND MEAN HEMATOLOCIL VALULb FOR FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYL I DENE CHLORIDE FOR 730 DAYS
Neutrophils 182 365 540 702
24 16 26 ND 8 u 13 ND
ND 23 1 5 38 23 ND ND ND 14 ND ND ND 13 L 2 20 ND ND 35 23 ND ND ND ND 41 ND ND ND 16 ND ND ND 34 ND ND ND 48 ND ND ND 25 ND ND ND 13 ND ND ND 20 ND ND ND 23 ND ND ND 43
16 19 19 30
7 y 13 24 17 9 9 ND ND 12 ND ND 16 14 ND ND 16 18 30 ND ND ND ND 24
4 ND 34 ND ND ND 26 ND ND ND ND 45 ND ND ND 24 ND ND ND 37 ND ND ND 29 ND ND ND 29 ND ND ND 33 ND ND ND 25 ND ND ND 21
12 12 22 29
Lympho cy tea 182 365 540 702
74 79 67 ND 87 87 82 ND ND 69 83 52 68 ND ND ND 80 ND ND ND 85 85 76 ND ND 62 73 ND ND ND ND 49 ND Nfi ND 81 UD ND ND 64 ND ND ND 49 ND ND ND 68 ND ND ND 82 ND ND ND 76 ND ND ND 66 ND ND ND 47
79 76 76 63
88 87 82 69 76 88 86 ND ND 86 ND ND 83 84 ND ND 80 77 65 ND ND ND ND 70 92 ND 59 ND ND ND 68 ND ND ND HD 50 ND ND ND 71 ND ND ND 58 ND ND HD 65 ND ND ND 65 ND ND ND 62 ND HD ND 67 ND ND ND 75
84 84 72 65
Monocytes 182 365 540 702
2 4 3 ND 4 2 3 ND ND 4 2 , 8 4 ND ND ND 3 ND ND ND 2 2 2 ND ND 0 2 ND ND ND ND 10 ND ND ND 2 ND ND m 3 ND ND ND 2 ND ND NO 5 ND ND ND 3 ND ND ND 4 ND ND ND 9 ND ND ND 10
3336
424 5 2 1 4 ND ND 1 ND ND 1 1 ND ND 3 4 6 ND ND ND ND 4 1 ND 3 ND ND ND 6 ND ND ND ND 5 ND ND ND 3 ND ND ND 5 ND ND ND 6 ND ND ND 5 ND ND ND 5 ND ND ND 7 ND HD ND 2
225 5
Eos tnophiIs
182 365 540 702
0 1 2 NI) 1 0 2 ND ND 4 0 2 3 ND ND ND
3 ND ND ND
0 1 l ND ND 3 L ND
ND ND ND 0
ND ND NIJ ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND
0 0 i 2 2 0 2
0
221i
1212 2 2 1 ND ND ] ND ND 0 1 ND ND 0 1 0 ND ND ND ND 2 3 ND i ND ND ND 0 ND ND ND ND 0 ND ND ND 2 ND ND ND 0 ND ND ND 0 ND ND ND 1 ND ND ND 0 ND ND ND 1 ND ND ND 2
12 1 1
Basophils 182 365 540 702
0 0 0 ND 0 0 0 ND ND 0 0 0 0 ND ND ND 0 ND ND ND 0 0 0 ND ND 0 1 ND ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0
0000
0 000 3 0 0 ND ND 0 ND ND 0 0 ND ND 1 0 0 ND ND ND ND 0 0 ND 0 ND ND ND 0 ND ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0 ND ND ND 0
1 000
ND * No data available
TABLE A-9
INDIVIDUAL AND MEAN RESULTS OF URINALYSIS FOR MALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 731 DAYS
Dose Level
ppm
Animal Number
Specific Gravity
MALES , DAY 181
0 74-3067
3069 5070 3072 3073
1.0h2
1.059 1.063 1.035 1.046
MEANiSD 1.053+0.012
50 74-3214
1.036
3216
1.044
3218 >1.066
3219
1.054
3221
1.033
MEANiSD 1.047i0.0i4
100 74-3175
1.044
3177
1.0 59
3179
1.044
3180
1.043
3183 >1,066
MEANiSD 1.051+0.011
200 74-3139 >1.066
3140
1.064
3141 3142 31++4
1.056 1.065 1.0 55
MEANiSD 1.061+0.005
PH
6.0
6.5 7.0 7.0 5.5
5.5-7.0
6.5 6*5 5.5
6.0
7.0
5.5-7.0
6.0 6.0
6.5
6.5
6.5
6.0-b.5
6.5
6.0
5.5 5.5
6*5
5.5-6.5
MALES, DAY 365
0 74-3066
3067 3068 3070 3071
1.038 1.047 1.04 7 1.049 1.044
MEANiSD 1.04510.004
50 74-3212 3213 3215 3217 3218
1.031 1.044
1 .033 1.026 1.038
MEANiSD 1.034Q.007
100 74-3175
1.027
3176
1.035
3182
1.054
3183
1.039
3184
1.028
MEAN+SD 1.0370.011
200 74-3137
3139 3140 3141
1.033
1.034
1.044
1.038
3143
1.033
MEAN+SD 1.0360.005
6.1) 6.0 6*5
7.0 6.5
6.0-7.0
7.0 6.5
6.0
6.5
6.0
6.0-7.0
6.5 6.5 6.5 6.5 7.5
6.5-7.5
7.0 6.5 6.5
6.0 6.0
6.0-7.0
Sugar Albumin Ketones Bilirubin
Occult Blood
Uro bilinogen
Meg. Neg. Neg. Neg. Neg,
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Meg. Neg.
Neg.
+3 +3 +3 +3
+2
+2 to +3
+3
+2
+3
+2 +2
4-2 to +3
+2
+3 4-3 4-2 4-4
4-2 to +4
+3 +3
+2
+3 +3
+2 to +3
Neg. Neg. Neg. Neg. Neg.
Neg,
Neg. Neg. Neg. Neg. Neg.
Neg.
Trace Neg, Neg. Neg,
Small
Neg.-Small
Small Neg. Neg.
Small Neg.
Neg*-Small
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg, Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Small
Neg. Neg. Small
Neg.-Small
Neg. Neg. Neg. Small Neg.
Neg.-Small
Neg. Neg. Neg . Neg, Neg.
Neg.
Neg. Neg. Neg. Neg. Neg .
Neg.
ND ND ND ND ND
ND
ND ND ND ND ND
ND
ND ND ND ND ND
ND
ND ND ND ND ND
ND
Neg. Neg. Neg. Neg ,
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg, Neg, Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
+2
4-3 +3 +3 +3
+2 to 4-3
+3 +3 4-3 +3 4-3
4-3
+3 +3 +3 4-3 +3
+3
+3 +3 4-3 +3 +3
+3
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg,
Neg. Neg, Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg,
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg, Neg. Neg. Neg.
Neg.
Nor. Neg, Neg. Neg. Neg.
Neg.
Neg, Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
. Neg. Neg. Sma 11 Neg.
Small
Neg. Neg. Neg. Neg. Neg.
Neg,
Neg. Neg, Neg. Nor . Neg.
Neg,
ND ND ND ND ND
ND
NT) ND ND ND ND
ND
ND ND ND ND ND
ND
ND ND ND ND ND
ND
ND - Not determined.
SL 082140
TABLE A-9 (cont'd)
INDIVIDUAL AND MEAN RESULTS OF URINALYSIS FOR MALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 731 DAYS
Dose Level
ppm
Animal Number
Specific Gravity
...... P.H
MALES,, DAY 540
0 74-3066 3067 3068 3070 3071
1.043 1.044
1.027 1.016 1.035
MEAN+SD 1.03310.012
50 74-3212 3213 3215 3217 3221
1.037 1.038 1.032 1.043 1.040
MEAN+SD 1.03810.004
'00 74-3175 3176 3182 3183 3184
1.031 1.022 1.038 1.015 1.053
MEANiSD 1,03210.015
74-3137 3139 3140 3141 3143
1.039 1.025 1.026 1.043 1.019
MEAN+SD 1.030+0.010
6.0 6,0 6.0 6.0 6.5
6.0-6. 5
6.0 6.0 6.0 6.0 6.0
6.0
7.0 5.0 5.0 6.0 6.0
5.0-7..0
6.5 6.0 6.0 7.0 6.0
6.0-7.,0
Sugar A1 bumin Ketones Bilirubin
Occult Blood
Uro bilinogen
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg, Neg. Neg.
Neg.
Nt Ne. Neg. Neg. Neg.
Neg.
+3 +3 +3 +3 +3 +3 +3 +3 +3 +3 +3
+3 +3 +3 +3 +3 +3 +3
+3 +3
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg +2 Neg.
Neg. to +2
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg Neg. Neg. Neg.
Neg.
0.1 0.1 0.1 O.l 0.1
0.1
0.1 0.1 0.1 0.1 0.1
0.1
0.1 0.1 0.1 0.1 0.1
0.1
0.1 0.1 0.1 0.1 0.1
0.1
SL 082141
TABLE A-9 (cont'd)
INDIVIDUAL AND MEAN RESULTS OF URINALYSIS FOR MALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 731 DAYS
Dose Level
PPm
Animal Number
Specific Gravitv
MALES, DAY 701
0 74-3056 3069 3080 3085 3086 3093 3095 3100 3102 3104
1,044 1.021 1,029 1,018 1.025 1.024 1.020 1.025 1.022 1.027
MEAN+SD 1.0260.007
50 74-3212 3213 3217 3227
3232 3236 3237 3247 3540
1.020 1.018 1.025 1.038
1.019 1.018 1.030 1.025 1.019
MEAN+SD 1.024+0.007
PH
6.0
6.0
6.5 6.5 6,0 6.5 6.0 6.0 6.0 5.5
5.5-6.5
6.0 6.0 6, Q . Q 6.5 5.5 7.0 6.0 6.0
5.5-7.0
100 200
74-3175 3186 3187 3191 3195 3199 3202
3208 3209 3512
1.055 1.026 1.022 1.025 1.034 1.018 1.025 1.035 1.049 1.030
MEAN+SD 1. 032t0.012
74-3137 3140 3141 3147 3148 3154 3170 3171 3498 3500
MEAN1SD
I.O26 1.020 1.047 1.020 1.036 1.038 1.024 1.038
ND 1.0 )0
1.031+0.009
6.0 6.0 5.5 5.0 6.0 7.0 6.0 6.0 6.0 5.5
5.0-7.0
6.0 6.0 6,5 6.0 6.5 6.0 6.0 6.0
ND 6,0
6.0-6.5
ND = not determined.
Sugar Albumin Ketones Bilirubin
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg. Neg Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg.
ND Neg.
Neg.
+3 +3 +3 +3 +3 +3 +3 +3 +3 +3
+3
+3 +3 +3 +3 +3 +3 +3 +3 +3
+3
+3 +3 +3 +3 +3 +3 +3 +3 +3 +3
+3
+3 +3 +3 +3 +3 +3 +3 +3 ND +3
+3
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg, Neg. Neg. Neg. Neg. Neg.
ND Neg.
Neg.
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg, Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg.
ND Neg.
Neg.
Occult Blood
Neg.
Neg.
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. feg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg. Nee. Neg. Neg. Neg. Neg
Neg.
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg.
ND Neg.
Neg.
Uro bilinogen
1.0 0.1 0.1 0.1 0.1 0.1 1.0 0.1 0.1 1.0
0.1-1.0
0.1 0.1 Q.l 0.1 Q.l 0.1 0.1 0.1 0.1
0.1
1.0 0.1 0.1 1.0 0.1 0.1 0.1 0.1 1.0 0.1
0.1-1.0
0.1 0.1 1.0 0.1 0.1 0.1 0,1 1.0
ND 0.1
0.1-1.0
SL 082142
TABLE A-10
INDIVIDUAL AND MEAN RESULTS OF URINALYSIS FOR FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING VNYLIDENE CHLORIDE FOR 730 DAYS
Dose Level
Animal Number
Specific Gravity
FEMALES,, DAY 182
0 74-3250 1.036
3252
1.024
3253
1.017
3254
1.015
3255
1.032
MEANiSD 1.025+0.009
50 74-3398 1.046
3399
1.041
3401
1.029
3402
1.042
3404
1.055
MEANiSD 1.043+0.009
100 74-3360 1.032
3361
1.023
7 363
1.064
J365 >1.066
3366
1.026
MEANiSD 1,042i0.021
200 74-3322
1.041
3323
1.043
3325
1.039
3326
1.032
3328 >1.066
MEANiSD 1.044+0.013
pH
6.0 6.5 6.5 6.0 5.5
5.5-6.5
6.0 6.0 5.5 6.5 5.5
5.5-6.5
6,5 6.5 6.0 6.0 7.5
6.0-7.5
6.0 6.5 5.5 5,5 6.0
5.5-6.5
0 50 100 200
FEMALES, DAY 365
74-3250 3252 3253 3254 3255
1.024 1.025 1.026 1.021 1.047
MEAN+SD 1.029+0.010
74-3398 3399 3400 3401 3402
1.053 1.036 1.043 1.025 1.028
MEANiSD 1.037i0.011
74-3360 3361 3362 3366 3368
1.033 1.028 1.029 1.034 1.038
MEAN+SD 1.0320.004
74-3322 3323 3324 3325 3326
1.047 1.036 1.035 1.039 1.044
MEANiSD 1.040+0.005
6,5 6.0 6.5 6.5 6.0
6,0-6.5
6.0 6.0 6.0 6,0 6.0
6.0
6.0 6.0 6.5 6.0 5.5
5.5-6.5
6.0 6.0 6.0 6.0 6.0
6.0
Sugar Albumin Ketones Bilirubin
Occult Blood
Urobilino1
Neg. Neg. Neg. Neg. Neg.
+2 +2 +2 +3 +2
Neg. +2 to +3
Neg. Neg. Neg. Neg. Neg.
+2 +2 +3 +1 +1
Neg. +1 to +3
Neg. Neg. Neg. Neg. Neg.
+2 +1 +3 +3 +3
Neg. +1 to +3
Neg. Neg. Neg. Neg. Neg.
+i +2 +3 +2 +3
Neg. +1 to +3
Neg, Neg. Neg. Neg. Neg.
Neg. Neg. Neg. Neg, Neg.
Neg,
Neg,
. Neg. Neg. Neg. Neg. Neg.
Neg. Neg . Neg. Neg. Neg.
Neg.
Neg.
Neg. Neg. Trace Neg. Neg.
Neg, Neg. Neg. Neg. Neg,
Neg.-trace Neg,
Neg. Neg, Neg. Neg. Neg.
Neg. Neg. Neg. Neg, Neg.
Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Trace Neg. Neg,
Neg.-trace
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
ND ND ND ND ND
ND
ND ND ND ND ND
ND
ND ND ND ND ND
ND
ND ND ND ND ND
ND
Neg. Neg. Neg. Neg. Neg .
+2 +3 +3 +3 +3
Neg. +2 to +3
Neg. Neg. Neg. Neg. Neg.
+3 +3 +2
+3 Trace
Neg. trace to +3
Neg. Neg. Neg. Neg. Neg.
+2 +3 +1 +3 +1
Neg. +1 to +3
Neg. Neg. Neg. Neg. Neg.
+i Trace
+3 +3 +3
Neg. trace to +3
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg,
Neg, Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
ND ND ND ND ND
ND
ND ND ND ND ND
ND
ND ND ND ND ND
ND
ND ND ND ND ND
ND
ND = Not determined.
*
SL 082143
t*
TABLE A-10 (cont'd)
INDIVIDUAL AND MEAN RESULTS OF URINALYSIS FOR FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 730 DAYS
Dose Level
ppm
Animal Number
Specific Gravity
pH
FEMALES, DAY 540
0 74-3250 3253 3254
3255 3257
1.035 1.039 1.034
1.048 1.030
MEANSD 1.037+0.007
50 74-3398 3399 3400 3401 3402
1.045 1 042 1.016 1.006 1.008
MEAN+SD 1.023 + 0.019
100 74-3360 3361 3362 3366 3368
1.034 1.038 1.012 1.041 1.031
MEANiSD 1.031+0.011
200 74-3322 3323 3326 3328 3329
1.03 3 1.038 1.050
1.025 1.040
MEAN+SD 1.0370.010
6.0 6.0 6.5 6.0 6.0
6.0-6.5
6.0 6.0 6.0 5.0 5.0
5.0-6.0
5.0 6.0 5.0 6.0 6.0
5.0-6.0
6.0 6.0 5.0 5.0 6.0
5.0-6.0
Sugar Albumin Ketones Bilirubin
Occult Blood
Uro bilinogen
Neg. Neg. Neg. Neg. Neg.
+3 +3 +3 +3 +3
Neg.
Neg. Neg. Neg. Neg. Neg.
+3
+3 +3 +3 +3 +1
Neg. +1 to +3
Neg. Neg. Neg. Neg. Neg.
+2 +3 +1 +3 +3
Neg. +1 to +3
Neg. Neg. Neg. Neg. Neg.
+1 +2 +3 +3 +3
Neg. +1 to +3
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg, Neg.
Neg.
Neg. Neg. Neg. Neg. Neg,
Neg.
Neg. Neg. Neg. Neg, Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg, Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg,
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg.
Neg.
0.1 0.1 0.1 0.1 0.1
0.1
0.1 0,1 0.1 0.1 0.1
0.1
0.1 0.1 0.1 0.1 0.1
0.1
1.0 0.1 0.1 0.1 0.1
0.1-1.0
o^44
TABLE A-10 (cont'd)
INDIVIDUAL AND MEAN RESULTS OF URINALYSIS FOR FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 730 DAYS
Dose Level
ppm
Animal Number
Specific Gravity
Occult
Uro
PH
Sugar Albumin Ketones Bilirubin
Blood
bilinogen
FEMALES, DAY 702
0 74-3255 3260 3267 3271 3272 3279 3280 3288 3291 3304
1.026 1.041 1.029 1.022 1.034
1.033 1.018 1.027 1.018 1.027
o. 5 6.0 6.0 6.0 6.0 6.0 6.0 6.0 6.0 7.0
MEAN+SD 1.0280.007 6.0-7.0
50 74-3399 3400 3402 3406 3408 3414 3415 3416 3418 3423
1.061 1.044 1.033 1.041
1.035 1.024 1.032 1.026 1.027 1.035
6.0 6.0 6.0 6.0 6.0 6.0 6.0 6.0 6.0 6.0
MEANiSD 1.0360.011
6.0
100 74-3362
3373 3376 3377 3379 3381 3387 3388 3393 3394
1.039
1.038 1.048 1.047 1.023 1.032 1.033 1.034 1.042 1.049
6.5
6.5 6.0 6.0 6.0 5.5 6.0 6.0 5.5 6.0
MEAN+SD 1.039 + 0.008* 5.5-6.5
200 74-3322 3327 3331 3334 3340 3346 3348 3355 3356 3580
1.025 1.026 1.017 1.040 1.034 1.025 1.029 1.057 1.035 1,040
5.5 6.0 6,0 5.5 6.0 6.0 6.5 6.0 6.0 6.0
MEAN+SD 1.033+0.011 5.5-6.5
Neg. Neg. Neg. Neg, Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg, Neg, Neg.
Neg.
Neg. Neg. Neg. Neg. Neg. Neg . Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
+3 +3 +3 +3 +3 +3 +3 +3 +3 +3
+3
+3 +2 +2 +3 +3 +3 +3 +3 +3 +3
+2 to +3
+3 +3 +3 +3 +3
+3 +3 +3 +3
+3
+3 +3 +3 +3 +3 +3 +3 +3 +3 +3
+3
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg, Neg. Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg, Neg. Neg,
Neg.
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg, Neg. Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg. Neg.
Neg.
0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
0.1
0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
0.1
0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
0.1
0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
0.1
'^Statistically significantly different Er:r.i control mean using Dunnett's test, p<0,05.
SL 08214^
TABLE A-U
INDIVIDUAL AND MEAN CLINICAL CHEMISTRY OF MALE AND FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 181 AND 184 DAYS
Dose Level (ppm)
Animal Number
BUN mg/I00 ml
DAY 181
0 74-3076 3077 3079 3081 308 3
20 21 18 20 21
MEAN+SD
20+1
50 74-3222 3223 3224 3227 3228
25 23 20 21 24
MEAN+SD
23i2
100 74-3174 3184 3185 3186 3187
20 20 20 18 19
MEAN1SD
19+1
200 74-3147 3148 3150 3151 3152
20 26 22 25 26
MEANfSD
24+2*
SGPT mU/ml
Males AP
mU/ral
58 362 70 462 65 376 83 250 66 392
68+9 3687 6
63 386 77 490 62 268 62 408 6 7 506
66 + 6 412+95
64 414 56 232 66 392 80 368 50 352
6311 352+71
74 716 68 526 o7 390 t f: 252
400
63+10 457+174
Glucose mg/100 ml
ND ND ND ND ND
ND
ND ND ND ND ND
ND
ND ND ND ND ND
ND
ND ND ND ND ND
ND
Animal Number
BUN mg/lOQ ml
Females
SGPT
AP
mU/ml
mU/ml
74-3270 3271 3272 3273 3274
MEAN4SD
74-3410 3411 3412 3413 3414
MEAN+SD
74-3370 3371 3372 3373 3374
MEAN+SD
74-3340 3341 3342 3344 3345
MEAN4SD
16 24 24 20 16
20+4
18 21 23 18 17
202
26 21 24 19 18
22 + 3
19 20 20 22 21
20+1
61 59 60 48 56
57+5
62 52 65 55 72
618
63 53 45 60 56
55+7
51 50 52 51 56
52+2
228 352 260 346 216
280+65
388 310 324 382 360
353+35
216 182 236 198 290
224+42
378 346 488 346 366
385+59*
DAY 184
0 74-3472 3474 3476
3478 3480
14 13 14 16 16
ND 113 ND 109 ND 114 ND 152 ND 184
ND
74-3552
22
ND 83
ND
3554
17
ND 92
ND
3556
18
ND 86
ND
3558
14
ND 90
ND
3560
20
ND 124
MEANiSD
15+2
ND 134i33
ND
MEANiSD
18+3
ND 95+17
50 74-3532 3534 3536 3538 3540
18 20 14 17 18
ND 137 ND 140 ND 128 ND 86 ND 143
ND
74-3612
22
ND 71
ND
3614
18
ND 96
ND
3616
16
ND 95
ND
3618
20
ND 63
ND
3620
16
ND 83
MEAN+SD
17 + 2*
m 127+24
ND
MEAN+SD
18+3
ND 82+15
100 74-3512 3514 3516 3518 3520
15 16 14 16 16
ND 127 ND 113 ND 160 ND 153 ND 121
ND
74-3592
18
ND 70
ND
3594
16
ND 78
ND
3596
18
ND 88
ND
3598
22
ND 104
ND
3600
18
ND 107
MEAN+SD
161
ND 135+21
ND
MEAN+SD
18 + 2
ND 89+16
200 74-3492 3494 3496 3498 3500
18 18 18 17 17
ND 123 ND 127 ND 123 ND 177 ND 115
ND
74-3572
18
ND 97
ND
3574
17
ND 74
ND
3576
20
ND 133
ND
3578
28
ND 98
ND
3580
20
ND 66
MEANtSD
18+1*
ND 133425
ND
MEAN+SD
20+4
ND 94+26
ND * not determined. Statistically significantly different from control mean using Dunnett's test, p<0.05.
Glucose mg/100 ml
ND ND ND ND ND
ND
ND ND ND ND ND
ND
ND ND ND ND ND
ND
ND ND ND ND ND
ND
ND ND ND ND ND
ND
ND ND ND ND ND
ND
ND ND ND ND ND
ND
ND ND ND ND ND
ND
SL 082146
TABLE A-ll (cont'd)
INDIVIDUAL and mean clinical chemistry of male and female rats maintained on drinking water CONTAINING VINYLIDENE CHLORIDE FOR 366 AND 541 DAYS
Dose Level (ppm)
Animal Number
___________ ___________ Males_________________
BUN SGFT AP
Glucose
mg/100 ml mU/ml
mU/ml
mg/100 ml
DAY 366
0 74-3074 3075 3076 3077 3078
lb 19 17 19 16
57 130 56 95 59 138 50 14 5 48 125
98 90 87 98 98
MEAN+SD
17i 2
54 + 5 12 7 i 19
945
50 74-3223 3226 3227 3228 3229
35 21 17 19 21
51 15 5 51 103 63 148 68 148 65 138
94 92 104 106 106
MEANiSD
21*1
60i8 138+21
1007
100 74-3186 3137 3189 3190
3191
14 16 38 30 18
b9 140 57 150 59 110 57 100 53 103
102 98 80 94 90
MEANiSD
23il0
59+6 121+23
93+8
:oo 74-3146 3147 3148 3149 3150
24 15 20 16 lb
57 183 51 135 56 185 60 108 54 118
90 88 89 79 86
MEANiSD
18i4
5o+3 146i36
86i4
DAY 3 41
0 74-3120 3121 3122 3123 3124
MEANiSD
I) 0 74-3234 3236 3237 3238 3239
MEANiSD
: on 74-3194 3195 3198 3199 3200
MEANtSD
200 74-3168 3170 3171. 3172 3X73
MEANiSD
18 16 24 15 14
17+4
44 21 15 13 34
2513
35 12 20 19 16
20+9
84 16 12 24 37
35i 29
52 51 67 42 65
55il0
55 67 66 42 40
54 + 13
33 56 43 57 43
46+10
28 46 64 55 58
50i 14
102 65
140 115 100
10427
82 79 126 107 84
96+20
82 131
85 112 142
110+27
106 104 146 133
95
117i22
ND ND ND ND ND
ND
ND ND ND ND ND
ND
ND ND ND ND ND
ND
ND ND ND ND ND
ND
ND = not determined.
Animal Number
______________________ Females
BUN
SGPT
AF
mg/100 ml mU/ml
mU/ml
74-3257 3258 3259 3261 3263
MEANiSD
74-3404 3405 3406 3407 3408
MEANiSD
74-3370 3371 3373 3375 3376
MEANiSD
74-3330 3331 3332 3333 3334
MEAN+SD
19 15 13 18 15
16+2
17 23 23 15 18
19+4
17 21 17 14 17
17+2
19 28 16 16 17
19+5
44 120 48 70 45 70 55 40 50 70
484
74+29
51 165 51 90 50 95 51 120
48 77
50+1 109+35
42 73 83 123 48 105 38 100 44 95
51+18 991B
52 75 51 160 53 125 51 130 44 105
50+4 119132
74-3304 3305 3306 3307 3309
MEANiSD
74-3426 3427 3428 3429 3430
MEANiSD
74-3388 3389 3390 3391 3392
MEANiSD
74-3346 3347 3348 3349 3350
MEAN+SD
12 15 13 15 16
14 + 2
20 15 19 13 14
16+3
16 13 19 16 15
16+2
15 24 13 20 15
17i4
58 ND 55 78 63 111 42 108 65 120
57+9 104+18
63 136 52 87 42 72 55 81 55 110
53+8
97 + 26
35 84 40 87 54 82 60 121 50 116
48il0 98119
72 119 47 67 45 80 38 61 64 144
53il4 94+36
Glucose m^/100 ml
78 116 106 104 100
101+14
99 93 74 73 86
85+11
82 72 92 92 90
86+9
100 80 84
100 90
91t9
ND ND ND ND ND
ND
ND ND ND ND ND
ND
ND ND ND ND ND
ND
ND ND ND ND ND
ND
SL 08214
TABLE A-11 front'd)
INDIVIDUAL AND MEAN CLINICAL CHEMISTRY OF MALE AND FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 707 DAYS
Dose Level (ppm)
Animal Number
_______ _________ Hales__________________________________________ Fannies
BUN SGPT AP
Glucose
Animal
BUN
mg/lOO ml mU/ml
mU/ml
mg/lOG ml
Number mg/100 ml
SGPT mU/ml
DAY 707
0 74-3066 3067 3069 3079 3080 3085 3086 3093 3095 3100
13 33 28 15 14 43 30 18 44 18
34 55 32 86 44 102 4 7 64
40 68 32 1225** 35 105 4 2 142 61 60 47 70
ND ND ND ND ND ND ND ND ND ND
74-3255 3260 3261 3262 3267 3271 3272 3273 3274 3279
15 19 16
19 15 12 22 14 14 24
64 60
36 26 32 35 16 24 35 23
MEANiSD
26rl2
41+9
85+27
ND
MEAN + SD
17 4
35+16
50 74-3212 3213 3217 3227 3232
3236 3237 3247 3540
32 153
29 23 29 79 22 22 175 ND
29 77 42 137 45 99 47 99 42 97 32 68 44 87 3 i 70 33 92
NT)
ND
74-3399
19
31
ND
3400
20
35
ND
3402
16
32
ND
3406
30
31
ND
3407
21
27
ND
3408
15
53
ND
3409
13
55
ND
3414
25
60
ND
3415
17
45
ND
3416
23
34
MEAN+SD 636Q*
40-3
9221
ND
MEAN+SD
205
40+12
100 74-3175 3186 3187 3191 3195 3199 3202 3208 3209 3512
34 36 32 72 18 50 22 38 17 20
94
i 71 43 90 24 64 4 1 110 45 103 38 86 45 91 40 101 31 58
ND
74-3362
12
46
ND
3364
11
34
ND
3365
14
46
ND
3369
20
48
ND
3384
19
32
ND
3376
11
21
ND
3377
19
34
ND
3378
27
32
ND
3379
30
37
ND
3382
27
36
MEAN+SD
34+17
38r7
8717
ND
MEAN+SD
197
37+8
200 74-3137 3140 3141 3147 3148 3154 3170 3171 3496 3498
18 29 14 36 15 25 23 15 26 31
61 78 45 72
48 73 37 88 43 81 50 13 2 39 99 48 121 64 116 37 123
ND
74-3322
11
47
ND
3327
16
48
ND
3331
24
35
ND
3334
12
41
NT)
3 340
19
35
ND
3344
15
44
ND
3345
17
27
ND
3346
18
48
ND
3348
16
31
NT)
3349
22
28
MEAN+SD
23+8
47t9
98223
ND
MEAN+SD
17+4
38+8
AP mU/ml
52 70 . 64 47 41 56 76 39 48 48
54+12
51 73 76 38 36 51 100 69 73 56
62+20
87 57 73 70 110 48 60 76 66 65
71+17
84 59 85 67 67 86 57 79 49 48
68+15
ND * not determined. *Statistically significantly different from control mean using Dunnett's test, p<0.05.
**Value omitted from statistical analysis.
Glucose ihr/100 ml
ND ND ND ND ND ND ND ND ND ND
ND
ND ND ND ND ND ND ND ND ND ND
ND
ND ND ND ND ND ND ND ND ND ND
ND
ND ND ND ND ND ND ND ND ND ND
ND
SL 082148
*:
TABLE A-ll (cont'd)
INDIVIDUAL AND MEAN CLINICAL CHEMISTRY OF MALE AND FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 730(F) and 731(M) DAYS
Dose Level
(ppm)
Animal Number
______________________
BUN
SGPT
mg/100 ml mU/ml
Males____________________
AP Glucose
mU/al
mg/100 ml
0 74-3066 3067 3069 3079 3080 3085 3086 3093 3095 3100
MEAN+SD
50 74-3212 3227 3232 3237 3247
MEANiSD
16 56 37 21 16 54 32 23 34 24
31+14
42 22 36 27 27
31i8
44 36 44 55 55 33 34 40 57 51
45+9
33 42 46 45 56
44+8
50 83 66 55 49 1425** 79 122 34 40
64+27
60 46 56 56 44
52i7
84 105
70 65 72 90 75 95 25 31
71i26
73 91 85 58 80
77il3
100 74-3187 3195 3199 3202 3208 3209 3512 3530
MEANiSD
49 19 93 24 51 18 23 49
41+26
39 45 30 35 46 51 39 44
41 7
98 71 102 57 61 59 33 64
68i22
83 84 75 74 75 75 83 75
784
200 74-3140 3141 3147 3148 3154 3170 3171 3496 3500
MEANiSD
34 18 53 19 21 30 17 18 32
27il2
50 49 45 44 54 49 56 51 36
48+6
51 58 75 59 75 68 74 55 47
62+11
50 82 80 78 74 51 64 80 35
6617
Animal Number
74-3255 3261 3267 3272 3 273 3274 3279 3283 3291 3294
MEAN+SD
74-3402 3406 3407 3408 3409 3414 3415 3418 3422 3423
MEANiSD
74-3362 3364 3365 3369 3376 3377 3379 3382 3384 3387
MEAN+SD
74-3322 3327 3331 3334 3340 3344 3345 3346 3348 3349
MEAN+SD
_____
BUN mg/100 ml
Females
SGPT mU /ml
AP mU /ml
21 18 17 24 17 22 21 17 07 20
18+5
17 32 23 15 17 11 30 23 19 17
20+7
15 14 18 24 18 21 37 39 17 18
22+9
15 16 36 15 19 17 19 26 17 25
20i7
58 44 36 18 37 23 46 46 56 31
40+13
36 35 42 60 36 52 42 58 39 49
45+9
46 41 45 35 32 42 44 40 34 158
52+38
42 68 68 52 34 39 29 60 31 33
4615
41 55 32 46 29' 33 94 72 83 150
64i38
76 31 26 42 45 48 53 19 51 28
42+17
60 38 53 46 79 56 48 45 71 45
54+13
70 43 86 48 35 62 38 51 34 40
51 + 17
Glucose mg/100 ml
57 72 50 74 42 74 60 100 77 87
69+17
70 100
40 59 73 70 100 73 79 80
74+18
83 73 74 72 91 100 50 81 62 91
78+15
97 83 83 51 82 15 125 82 88 93
80+29
**Value omitted from statistical analysis.
SL 082149
TABLE A-12
INDIVIDUAL AND MEAN BODY WEIGHTS, ORGAN WEIGHTS, AND ORGAN/BODY WEIGHT RATIOS FOR MALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 731 DAYS
Dose PPm
0
50
Animal Number
74-3066 74-3067 74-3069 74-3079 74-3080 74-3085 74-3086 74-3093 74-3095 74-3100 74-3101 74-3110 74-3120 74-3124 74-3130 74-3132 74-3472 74-3474 74-3846
MEAN S.D.
74-3212 74-3227 74-3232 74-3237 74-3247
MEAN S.D.
Fasted Body
Weight
8
491 408 522 497 535 591 610 585 458 546 478 569 607 421 514 581 495 402 513
517 65
611 313 503 506 512
489 108
______________________________ Organ Weights (g and g/lOOg Body Weight)
Brain
Heart
Liver
Kidneys
8
2.10 2.10 1.96 2.05 2.09 1.87 1.97 1.94 1.95 1.99 1.97 1.99 2.03 1.95 2.16 2.05 1.95 1.93 2.00
s/lOOg
0.43 0.52 0.38 0.41 0.39 0.32 0.32 0.33 0.42 0.36 0.41 0.35 0.33 0.46 0.42 0.35 0.39 0.48 0.39
8
2.13 2.33 2.01 1.71 1.88 2.32 1.79 2.02 2.03 1.91 1.61 2.00 2.09 1.99 1.74 1.74 1.90 1.85 2.07
a/iooa
0.43 0.57 0.38 0.34 0.35 0.39 0.29 0.34 0.44 0.35 0.34 0.35 0.34 0.47 0.34 0.30 0.38 0.46 0.40
17.33 20.39 20.85 34.30 17.63 25.86 20.53 17.98 17.94 17.87 15.80 20.29 17.96 18.05 16.27 19.91 16.68 14.99 16.98
K/100g
3.53 4.99 3.99 6.90 3.30 4.38 3.36 3.07 3.92 3.28 3.30 3.57 2.96 4.29 3.17 3.43 3.37 3.73 3.31
4.31 11.91
7.22 5.09 6.33 7.13 5.57 3.74 5.29 5.17 5.32 6.48 5.48 4.84 3.97 6.79 4.91 9.91 4.65
g/lOOg
0.88 2.92 1.38 1.02 1.18 1.21 0.91 0.64 1.15 0.95 1.11 1.14 0.90 1.15 0.77 1.17 0.99 2.46 0.91
2.00 0.07
0.39 0.05
1.95 0.19
0.38 0.07
19.35 4.36
3.78 0.91
6.00 2.02
1.20 0.56
2.04 2.12 2.05 2.04 2.09
2.07 0.04
0.33 0.68 0.41 0.40 0.41
0.45 0.13
1.74 1.99 1.85 1.62 2.09
1.86 0.19
0.29 0.64 0.37 0.32 0.41
0.40 0.14
19.79 20.75 15.63 15.04 17.09
17.66 2.52
3.24 6.63 3.10 2.97 3.34
3.86 1.56
6.86 6.18 5.62 4.45 5.82
5.79 0.89
1.12 1.98 1.12 0.88 1.14
1.25 0.42
Testes
8
4.59 3.46 4.10 4.58 3.55 4.15 3.67 3.39 3.68 2.71 3.72 4.45 4.03 2.13 4.65 3.63 4.21 2.60 4.33
g/lOOg
0.94 0.85 0.79 0.92 0.66 0.70 0.60 0.58 0.80 0.50 0.78 0.78 0.66 0.51 0.91 0.62 0.85 0.65 0.84
3.77 0.70
0.73 0.14
4.12 4.66 4.15 4.41 2.18
3.90 0.99
0.67 1.49 0.82 0.87 0.43
0.86 0.39
SL 082150
Dose ppm 100
200
Ui
tr*
TABLE A-12 (cont'd)
INDIVIDUAL AND MEAN BODY WEIGHTS, ORGAN WEIGHTS, AND ORGAN/BODY WEIGHT RATIOS FOR MALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 731 DAYS
Animal Number
74-3187 74-3195 74-3199 74-3202 74-3208 74-3209 74-3512 74-3530
MEAN S.D.
74-3140 74-3141 74-3147 74-3148 74-3154 74-3170 74-3171 74-3496 74-3500
MEAN S.D.
Fasted Body
Weight g
396 629 319 662 480 622 548 473
516 121
476 532 432 684 546 566 409 590 493
525 85
Brain
g g/100g
1.98 1.96 1.84 2.10 2.04 2.13 2.00 1.98
0.50 0.31 0.58 0.32 0.42
0.34 0.37 0.42
2.00 0.09
0.41 0.09
2.03 2.09 1.89 1.97 1.97 2.02 1.97 1.94 1.95
0.43 0.39 0.44 0.29 0.36 0.36 0.48 0.33 0.40
1.98 0.06
0.39 0.06
Orsan Weights (g and g/lOOg Body Weight)
Heart
Liver
Kidneys
g
1.75 1.99 1.99 2.25 2.05 2.06 1.66 2.02
g/lOOg
0.44 0.32 0.62 0.34 0.43 0.33 0.30 0.43
g
14.86 18.41 14.10 20.37 18.46 16.57 16.96 15.95
g/100g
3.75 2.93 4.42 3.08 3.84 2.66 3.10 3.37
g
11.54 4.73 6.61 6.37 6.41 4.46 5.54 6.58
g/lOOg
2.91 0.75 2.07 0.96 1.33 0.72 1.01 1.39
1.97 0.19
0.40 0.11
16.96 2.06
3.39 0.58
6.53 2.19
1.39 0.75
1.70 2.13 1.86 2.12
1.73 2.06 1.77 2.01 2.38
0.36 0.40 0.43 0.31 0.32 0.36 0.43 0.34 0.48
15.83 15.64 17.74 19.41 16.80 17.70 15.57 18.78 20.27
3.33 2.94 4.10 2.84 3.08 3.13 3.81 3.19 4.11
6.19 4.55 7.21 4.01 4.90 5.93 4.20 5.27 6.69
1.30 0.85 1.67 0.59 0.90 1.05 1.03 0.89 1.36
1.97 0.23
0.38 0.06
17.53 1.72
3.39 0.49
5.44 1.13
1.07 0.32
Testes
g g/100g
2.04 4.10 2.82 4.69 4.50 4.33 3.89 4.05
0.52 0.65 0.88 0.71 0.94 0.70 0.71 0.86
3.80 0.91
0.74 0.14
3.69 4.86 3.95 4.94 4.56 4.65 3.29 4.42 3.21
0.78 0.91 0.91 0.72 0.84 0.82 0.80 0.75 0.65
4.17 0.66
0.80 0.09
082151
I
TABLE A-13
INDIVIDUAL AND MEAN BODY WEIGHTS, ORGAN WEIGHTS, AND ORGAN/BODY WEIGHT RATIOS FOR FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 730 DAYS
Animal Number
74-3255 74-3261 74-3267 74-3272 74-3273 74-3274 74-3279 74-3280 74-3283 74-3291 74-3294 74-3295 74-3296 74-3297 74-3298 74-3299 74-3300 74-3304 74-3306 74-3311 74-3315 74-3317 75-3568
mean
S.D.
Fasted Body
Weight
g
291 443 380 416 468 392 425 284 392 328 559 486 409 482 488 253 386 288 318 291 402 379 313
386 80
_____________________Organ Weights (g and g/lOOg Body Weight)
Brain g g/lOOg
Heart g g/lOOg
Liver R g/lOOg
1.79 1.85 1.88 1.89 1.86 1.87 1.91 1.81 1.85 1.75 1.86 1.82 1.82 1.86 1.93 1.95 1.83 1.80 1.77 1.84 1.93 1.78 1.88
0.62 0.42 0.50 0.46 0.40 0.48 0.45 0.64 0.47 0.53 0.33 0.37 0.44 0.39 0.40 0.77 0.47 0.62 0.56 0.63 0.48 0.47 0.60
1.38 1.40 1.34 1.77 1.42 1.41 1.73 1.25 1.32 1.39 1.78 1.42 1.61 1.52 1.54 1.40 1.28 1.23 1.15 1.55 1.35 1.42 1.21
0.47 0.32 0.35 0.42 0.30 0.36 0.41 0.44 0.34 0.42 0.32 0.29 0.39 0.31 0.31 0.55 0.33 0.43 0.36 0.53 0.34 0.37 0.39
13.55 13.72 11.81 19.93 17.30 15.63 17.63 12.72
9.44 14.45 14.73 15.68 20.03 14.71 14.68
9.72 14.09 10.28
8.48 9.65 14.30 12.18 9.02
4.66 3.10 3.11 4.79 3.69 3.99 4.15 4.48 2.41 4.40 2.63 3.23 4.89 3.05 3.01 3.84 3.65 3.56 2.67 3.32 3.56 3.21 2.89
Kidneys
R g/lOOg
3.80 2.71 3.21 2.97 3.04 3.26 3.09 3.19 2.77 3.36 3.08 2.58 3.90 4.64 2.79 2.80 2.68 3.23 2.59 2.53 3.32 3.03 2.42
1.30 0.61 0.85 0.71 0.65 0.83 0.73 1.12 0.71 1.02 0.55 0.53 0.95 0.96 0.57 1.11 0.70 1.12 0.81 0.87 0.83 0.80 0.77
1.85 0.05
0.50 0.11
1.43 0.17
0.38 0.07
13.64 3.28
3.58 0.72
3.09 0.51
0.83 0.20
SL 082152
TABLE A-13 (cont'd)
INDIVIDUAL AND MEAN BODY WEIGHTS, ORGAN WEIGHTS, AND ORGAN/BODY WEIGHT RATIOS FOR FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 730 DAYS
Dose EE_ 50
Animal Number
74-3402 74-3406 74-3407 74-3408 74-3409 74-3414 74-3415 74-3418 74-3422 74-3423 74-3425 74-3426 74-3427 74-3428 74-3430 74-3435 74-3612 74-3624
MEAN S.D.
Fasted Body
Weight
g
319 443 589 376 341 333 341 409 401 391 302 341 488 351 361 403 278 326
377 74
Brain
g
1.94 1.87 1.84 1.78 1.77 1.98 1.86 1.89 1.77 1.89 1.81 1.91 1.92 1.93 1.85 1.89 2.07 1.87
g/lOOg
0.61 0.42 0.31 0.47 0.52 0.59 0.54 0.46 0.44 0.48 0.60 0.56 0.39 0.55 0.51 0.47 0.74 0.57
Organ Weights (g and g/lOOg Body Weight)
Heart
Liver
g
1.32 1.66 1.58 1.43 1.05 1.29 1.40 1.39 1.18 1.29 1.45 1.60 1.27 1.28 1.47 1.33 1.54 1.68
g/lOOg
0.41 0.37 0.27 0.38 0.31 0.39 0.41 0.34 0.30 0.33 0.48 0.47 0.26 0.36 0.41 0.33 0.55 0.52
g
8.69 15.19 16.21 11.86 10.53
9.48 14.34 17.23 12.17 10.69 11.09 11.93 12.74 10.76 11.62 15.54 11.54 11.57
g/lOOg
2.72 3.43 2.75 3.15 3.09 2.85 4.20 4.21 3.04 2.73 3.68 3.50 2.61 3.06 3.22 3.86 4.15 3.55
Kidneys
g
2.45 3.15 3.08 3.33 2.54 2.75 3.59 3.74 2.80 2.51 3.69 2.85 2.63 2.75 3.13 2.57 3.19 3.40
g/100g
0.77 0.71 0.52 0.88 0.74 0.83 1.05 0.92 0.70 0.64 1.22 0.84 0.54 0.78 0.87 0.64 1.15 1.04
1.88 0.08
0.51 0.10
1.40 0.17
0.38 0.08
12.40 2.37
3.32 0.53
3.01 0.42
0.82 0.20
SL 082153
SL O82154
TABLE A-13 (cont'd)
INDIVIDUAL AND MEAN BODY WEIGHTS, ORGAN WEIGHTS, AND ORGAN/BODY WEIGHT RATIOS FOR FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 730 DAYS
Dose PPm
100
Animal Number
74-33b2 74-3364 74-3365 74-3369 74-3376 74-3377 74-3379 74-3382 74-3384 74-3387 74-3388 74-3389 73-3391 74-3392 74-3394 74-3598 74-3606
MEAN S.D.
Fasted
Weight 8
389 319 356 457 660 487 383 432 393 328 394 631 330 309 371 321 330
405 104
_______________ ______ Organ Weights (g and g/lOOg Body Weight)
Brain
Heart
Liver
g
1.90 1.72 1.77 1.92 1.83 1.88 1.86 1.74 1.76 1.75 1.84 1.80 1.74 1.78 1.86 1.91 1.81
g/100g
0.49 0.54 0.50 0.42 0.28 0.39 0.49 0.40 0.45 0.54 0.47 0.29 0.53 0.58 0.50 0.59 0.55
g
1.29 1.31 1.35 1.53 1.34 1.36 1.71 1.71 1.65 1.57 1.26 1.59 1.37 1.44 1.52 1.53 1.69
g/lOOg
0.33 0.41 0.38 0.33 0.20 0.28 0.45 0.40 0.42 0.48 0.32 0.25 0.42 0.47 0.41 0.47 0.51
g
13.03 10.00 11.72 16.65 17.86 13.24 16.58 16.08 15.65 10.89 10.85 20.59 10.66 10.58 12.74 10.43 12.08
g/lOOg
3.35 3.14 3.29 3.64 2.71 2.72 4.33 3.72 3.98 3.32 2.76 3.26 3.23 3.42 3.43 3.25 3.66
Kidneys
g
2.61 2.69 2.81 3.40 2.99 2.75 3.21 3.46 3.02 3.07 2.61 3.00 2.44 3.40 3.23 2.92 3.57
g/lOOg
0.67 0.84 0.79 0.74 0.45 0.56 0.84 0.80 0.77 0.94 0.66 0.48 0.74 1.10 0.87 0.91 1.08
1.81 0.06
0.47 0.09
1.48 0.15
0.38 0.09
13.51 3.41
3.37 0.43
3.01 0.33
0.78 0.18
*
TABLE A-13 (cont'd)
INDIVIDUAL AND MEAN BODY WEIGHTS, ORGAN WEIGHTS, AND ORGAN/BODY WEIGHT RATIOS FOR FEMALE RATS MAINTAINED ON DRINKING WATER CONTAINING VINYLIDENE CHLORIDE FOR 730 DAYS
Dose PPm 200
Animal Number
74-3322 74-3327 74-3331 74-3334 74-3340 74-3344 74-3345 74-3346 74-3348 74-3349 74-3355 74-3356 74-3574 74-3580 74-3586
MEAN S.D.
Fasted Body
Weight g
364 364 340 423 434 335 547 319 395 660 498 368 468 334 399
417 94
Brain
g
1.96 1.85 1.80 1.83 1.88 1.90 1.86 1.73 2.10 1.78 1.89 1.87 1.80 1.89 1.81
g/100g
0.54 0.51 0.53 0.43 0.43 0.56 0.34 0.54 0.53 0.27 0.38 0.51 0.38 0.57 0.45
Organ Weight s (g and g/lOOg Body Weight)
Heart
Liver
g
1.31 1.44 1.31 1.37 1.52 1.28 1.26 1.39 1.38 1.60 1.50 1.50 1.43 1.46
1.47
g/lOOg
0.36 0.40 0.38 0.32 0.35 0.38 0.23 0.43 0.35 0.24 0.30 0.41 0.30 0.44 0.37
8
12.22 10.97 10.52 12.44 13.61 11.45 19.23 11.15 14.04 16.92 15.19 13.92 17.52 11.35 19.92
g/100g
3.36 3.01 3.10 2.94 3.13 3.41 3.51 3.50 3.55 2.57 3.05 3.78 3.74 3.40 4.99
Kidneys
g
3.09 2.92 2.55 2.80 2.71 2.54 2.99 2.69 3.37 3.10 2.94 2.75 2.83 2.87 3.29
g/100g
0.85 0.80 0.75 0.66 0.62 0.76 0.55 0.84 0.85 0.47 0.59 0.75 0.60 0.86 0.82
1.86 0.09
0.46 0.09
1.41 0.10
0.35 0.06
14.03 3.09
3.40 0.55
2.90 0.24
0.72 0.13
SL 082155
*7