Document npdwOQ2w6dqEL75rVB59xDLem

FILE NAME Industrial Hygiene Foundation IHF DATE 1937-1957 DOC IHF100 DOCUMENT DESCRIPTION Reference Cards LE6T - 1. DIGEST 1937 CLAstiPiecy 3Uaseey . |] surnon: Roe iz 45 1239-12 SUBJECT # 48D 1239-12 # . 1239-12 1239-12 FELOWSHIP Tre: | : RL. Thorne @ Var Coty ~ | FELOWSHIP FILE 7742 ~ 7742 NUMER . RIRAer,sa POSITION RESEARCH TITLE TITLE RESEARCH =~ Es Bw INDUSTRIAL 4 c . EXCELENT | 6 Fa = ff RESEARCH PUBLISHER INDUSTRIAL INDUSTRIAL rINDUSTRI.AL aSBURGU , J i 7 SBURGU SBURGU TABLE_ 2 R.B. Fisher fi Possible .. Paligorskite Paligorskite possible possible Paligorskite Ci of Inf Circ DATE Mar DATE . ILLUSTRATIONS tony MAPS DATA is Cott asbestos substitute substitute ADMINISTRATIVE PROPAGANDA PROPAGANDA YOU | gp, | Date fiXCELLews, USELESS PURPOSE Probably ABSTRACT ; * ~ 2 ~. Paligorskite Paligorskite Paligorskite Paligorskite Paligorskite is probably probably poligorskite poligorskite t | i .WEES ey aNned it * r e mo "ov y fing DATE eS ee. BLANK FOR SOOM ETS, ARSTR Gy BLANK ANSTRACT ANSTRACT . PULLating, AOVERTi Sing ere wee CONT:p ao > foere te heel a a ONie Per Neeaemade <e tere ne ema: tea +. Ae on gee, eta en board board board FILE teeny c Dar +. see eve pen oe goeeaey mene and ey +: within of = ie _ favour the retention particles the See me ome ee ee ee oe oe lungs Particles under microns in length restricted cellular 5 5 the reason for that motility more than larger particles they were more readily phagocytosed It would phagocytes wandering wandering are rarely able to ingest particles seem that microns Giant cells sometimes formed in tissue larger than 10 fusion of two or more ordinary phagocytes and cultures apparently apparently apparently by larger particles or clusters of were then able to engulf of of bodies in particles 6 TThher eere was no evidence the formation of asbestos experiments these of brown granulur nor have we noted the ap- apenairmeanlcse pigment like that seen in the lungs of experimental i] -- Authors summary + + . .. " oe - ee ' ! I : ' } . : : : i ? : te cemees beeee e te le eee eee - mew. . ! ' . + eee . - . o. :- | | J : : i . ol . Te eee dew ee cee re oe fea a : { ! : i } H ; eee ee eteceee i ay cme, ve See ecm -. - i { en per . i \ - oee e . weer owe, : : . ah eee . te : H - ~ : . - ' eG ' - ; | . i; - | e ee c ; ata a a 4 4 Po ar ree | . : t . . . : ; wit : ! -. - wc 409-4 47 anal Soyer es | | FELLOWSHIP FILE NUMBER -44 10M i T PORK AUTHORI L. Noro me ee ee TITLEI Histology of asbestosis Pa Acta Pathol& icro- 23 | 53-59 | 1946 | a -- - ~ | PIT~buron Two workers in an asbestos factory died under circumstances which indicated that the cause of death was their trade When the workers of this factory were examined roentgenologically asbestosis was found in 65 per cent of the 167 workers examined The microscopic picture of asbestosis is characterized by a reaction caused by the needles in the tissue which be- Instiue comes manifest in exudate cell infiltration accompanied by numerous giant cells containing foreign particles and an increase of interstitial connec- tive tissue and fibrosis Noro is inclined to think that in the pathogenesis of asbestosis the mechanical factors are the most important although the chemical factors may have some significance in a later phase - J.A.M.A. - 4. Ls pee MELON 1 - 3 aan . ra er ao Sn Ce rt os Sse cmb eedar! pie wares ae fee meme 8 EXAMINED PURPOSE DATE ab . wee yoke SS rot . ee : 2.8 4 ae errs : - ~ Y mo, OF SEARCH ABSTRACT BLANK FOR GENERAL USE : . ? . . . . CONT'DI CONT'DI bal , - 37 FORM CLASSIFI BULJECT 7/18 4.148-2 FELLOWSHIP : | FILE NUMBER . AUTHORI Luton Champeix and Faure me - Asbestosis of the lungs PA ORIG REI Arch d woe . YOL toe =e. a . DATE ff 1946 ARSTR REFS Occ Med YOL or. DATE mal profess.7 | 299 | ABSTRACh Settee. g im. er ~ - --.. A review of the literature reveals no previous cases of asbestosis PITSBURON France but the authors have seen several cases in a factory in which asbes- tos is used and in which they make regular examinations Details in one case of a man of 64 exposed to concentrations of 48 to 62 are given dust per cubic meter total silica 40 and free silica 4.3 to mg 14.6 of Com- INATI UTE plaints of wealmess dyspnea coughing and loss of weight were noted in INATITUTE 1943. Thoracic expansion was cm In the sputum asbestosis bodies found but no tubercle bacilli were Roentgenography showed much more fibrosis than usual in the lower third of the lungs During the next two symptoms became more severe years the MELON -- From Occ Med DATE EXAMINED EXAMINED EXAMINED - ~ oe . PT, . . FER T - . : PURPOSE OF BEARCHI ABSTRACT BLANK FOR GENERAL USE CON CONT'D T e ' e D sey we ee em ne uate appa tne OUT ... ( NX PA z 2 f & O ey & Da = < = & fi CLaspzivren : | 1 CLASSIFIED | 407- sumer 147147 . - 8 \ al tae Nn wares area, TR OE es ee 147 \ and R.J. Ritterhoff - mee NFC FELLOWSHeIP NFC oe KUMBER oS ee NUMBER NUNOER 752 l. . 752 ie reniom AUTHORI . Skavlem Se R.J. asbestosis sarcoidosis sarcoidosis ORIG, : Am.J. Path. Am.J. aeevRact, . . . You, es 1493-517 VOL js 1493-517 DATE May146 , ABETH REFB JIH JIH = Mar.147 _ Mar.147 29 29 Mar.147 , _ increasing rPersopviiroautsolryy for coexistent This is a 1 necropsy ABSTRACTI year report of a This is necropsy necropsy respiatory respiratory old man died died respiratory respiratory : death after 11 months increasing increasing severe exertional dyspnce the patient had worked years severe an asbestos plant pathologi- pathologi- asbestosis and sarcoidosis both lungs J.I.H. lungs J.I.H. T ee T tree e ie pee ii a RYee a ee FM mee ee ae . eG Bee ee eee tes. - ome en ae : ~o fo . - talenationd - ome al o-- - re bees eee . la as wed Lg - 2 ; : . | DATE \ ss. FFR : OF PURPOSE ABSTRACT BLANK POR CEmMamAL wos : | aoe ee te CLAS IFIED CLASSIFIED SUBJRST , - . oO , a ot ; : | FILLOWSHIP FILLOWSHIP FILE NUMBER NUMBER | _ 752 AUTHOR E.J. E.J. King J.W. J.W. Clegg and V.M. V.M. Rae TITLE Effecotf asbestos and of asbestos and aluminum on lungs of rabbits PA er meme emus Sanna one - tee + ween 0 re seme cee ORIG REFI VOL DATE - mse ASSTR REPS - Thorax 1 188-197 | _=iyj. Sept. | JAMA | VOL or. 208 133 BATZ Jan. 1 1947 PITSBURG ABSTRACTI The purpose of the experiments described by King and his associates was to test whether short fiber asbestos is less damaging in the lungs of the rabbit than is long fiber asbestos and whether metallic alumimm will suppress any toxic effect produced by fiber asbestos Four groups of animals were tested All groups showed & foreign body reaction in the INST UE lungs In animals in the long fiber experiments there developed a nodular reticulinosis comparable with the experimental silicotic nodule In ani- mals in the short fiber experiment there developed a diffuse interstitial did reticulinosis The addition of aluminum not afford any benefit in any group - J.A.M.A. . r MELON en te nae Taree vem cmt me om oo pam + geen eee em ee. we ws. woe mem et dee gee we eee eed ee ee - oe a aa a te ee DATE PURPONE eee ue meee ee tte me eee ~ ee ; HIAMINER 15.FFR 15.FFR JAMA OF SEARCH | oy ABSTRACT BLANK FOR GENERAL USE s ee oe ee ne we note igs - ne * LASSIFIED / Pe re ST UMS og. 1 petrowenr eee PELLOWSHIP PiILe NUMBER PILE NUMBER - AUTHORI . // 1045-9 AUTHORI Wegelius Changes Changes a oe. in lungs en seteemm in 126 cases nee mS es ove of ee awe ne asvestoeis observed in asbestosis asbestosis asbestosis asbestosis observed observed observed in vo. Finland. = par Finland a need ABSTR, AEFE.? Radiologica 139-1521947139-1521947 | -_ - Pa. , ROFE-+ Pittsburgh eee YOL pe DATE 139-1521947 AUSTA 129-- DAI PITSnuURGN, INATLUE, MELON a@isease not often ritherto industrial Pittsburgh Asbestosis the lungs is an often hitherto hitherto Asbestosis Scandinavia not observed only five cases indub striae l de isen ase published published Norway asbestos an observed where considerable considerable established established established In Finland where asbestosis of the industry has occur an appreciable apreciable appreciable of decades an account appears appears occur asbes- extent The author gives being 126 cases of asbes- tosis . of these cases % 75 or 94 in the moderate lungs and % 9 or advanced stage the mild in the of asbestosis asbestosis The The roentgenological roentgenological roentgenological of the changes the dif- im- roentgenological characteristics classification classification in different lungs a im- diagnosis diagnosis the discussed different stages and The portance of asbestosis asbestosis time of exposure are -~ detail different stages illustrated asbestosis of the lungs are Author's Author's summary meee ee ae Author's summary ewes Le eee eet ow - ety Oe - a _ a aE TS ee mere oe a oe eee ee em ee we a eee oe mone ees eee on ote a s alo -- wae + ae aw a ee - = ae Br tee eee met - eee cee ermine we eres wes : ce CowTDr emesis Author's Author's Author's summary summary cum emmnme CONT ee ne se EXAMINE DATE Exami_neD: eretees BY WER Author's BY: Wye summary SEARCHI SEARCHI oe SEARCHI | ABSTRACT BLANK GENERAL GENERAL GENERAL petwae e se ey a rea Ce O d seen meee SEIFICO SUBJECT 172 - 172 172 172 WW W : : Soe ee : : . , . ae ee een - - FELLOWSHIP HUNBER HUNBER = st FILK NUMBER AUTHOR TITLO P. Luton J. Champeix and P. Faure - the The significance of | of asbestos bodies in the sputum of presence Pa ORIG REF9.5 asbestos workers Co VOL Lees ; DATE ASSTR REYS.1 DATE profess.8 1947 | | Arch malad French 56-58 1 Ind Hyg Index photomicrographs 304 NDove.c- '.47 PITSBUron persons who worked had worked with asbestos ~~ ABSTRACTI 33 ref 7 photomicrographs | The authors examined 176 or ; They find that asbestos bodies appear somewhat early in the sputum of these workers sometimes after only 20 days from the time of exposure These fibers | may persist even after cessation of exposure but occur in almost all workers exposed to asbestos dust whether they exhibit functional or radiographic evi- INST UE dence of asbestosis or not Brown or golden yellow bodies are seen in the sputum along with uncolored fibers or spicules The presence of these bodies more or less scattered indicates that the subject has inhaled asbestos dust but it does not necessarily signify that asbestosis exists In other words the discovery of asbestos bodies in the sputum is only one in the ensemble of Mel on elements which permit such a diagnosis It is true that in the cases where asbestosis is predicated by reason of the intensity manifestations and radiographic signs numerous asbestos bodies majority of of functional are noted massed together and displaying a rediate formation As such they are iden- tical to the clumps that are observed on histological examination of the lungs of deceased cases in the alveoli -- Ind Hyg Index EXAMINED i --FFR Ind.Hvg Ind.Hvg Index j PURPOSE SEARCH ABSTRACT SLANE FOR GENERAL USE eee a : some - one see power ; j CLASSIFIED SUBJECT Letnany ---- 327-3 # 327-3 327-3 162 327-3 / 327-3 name mine ea Sie e meeBt ee see one SOS OE COPOC a OO AUTHORITY Anon Safety Rev. U.S. Navy . CC OE FELLOWSHIP ra | HUNDER FILE NUMBER ' 752 71744 71744 Asbestos dust . wee meet PITSBURGH ORIG REFE VOL AUSTR RAPS.J Safety Rev. see come 4 15 Jan. ABSTRACT Instiue 147 EXAMINER The brief article calls attention tothe hazard of exposure to asbestos dust and the need of adequate localized ventilation All working : places with possible exposure should be checked asbestos dust and others for mechanical exhaust ventilation must be by wearing of personal supplemented protective equipment it should conform of Mines specifications MELON Bureau . a SEARCH DATE EXAMINER Pa PURPOSE OF ABSTRACT BLANK FOR GENERAL USE CONT'D eee \as . ied , er 7 Fan AUTHORS AUTHORS . Ona, werg., T.E. Belt, J. Friedmann E.J. E.J. King . T.H. Belt J. Friedmann tissue tissue cultures effect effect coal dust ee ORIG KEF8 & Beet. aanndd coal VOL 15195-9-116644 DAYR DAYR 1947 . A86TR STE.1 A86TR PILLOWSHIP | NUMBER NUMBER comparative comparative with with vou OLpe, ; O4re a abstract | ABSTRACT Phagocytosis even of small particles rsBuran in i Phagocytosis Phagocytosis a considerable exists exists place approxi- in tissue cultures cultures remained portion the the asbestos phagocytes phagaopcpyrtoexsi- mately per untouched though within experiments Compared with range asbestos less throughout phagocytosed particle size coal quartz Asbestos particles particles in readily phagocytosed phagocytosed little being equal ) Asbestos small small amount or fibroblasts no toxic effect on living accelerated accelerated cultures cultures Instiue, The growth was neither retarded no necrosis growth observed as a result of nor asbestos particles while of cells appeared to contact with asbestos while fetty phagocytes appeared Asbeosctcousr more slowly in asbestos vispihbagloecytes in coal particular particles underwent and in MEL ON particular forvisible diminution in size after having been ingested and in for long as five weeks 4 The motility of wandering phago- phagocytes phagocytes decreased after the ingestion particles particles This effect cytes necessarily necessarily of toxic of deleterious deleterious case not necessarily lungs since it character restrict the migration of cells cells tends to restrict the cells so so pave . Authors migration of cells CONT'O CONT'O DATE . Summary oy, SEARCH TED OF SEARCH CONT DO: ABSTRACT BLANK FOR GENERAL uses - Sthan er Sthan general - tosis This ary incidence in cases figure is in accordance ae . r of medium advanced a80e8- with the experience of other workers and calls for further study Tuberculosis occurred in six cases but it is _ suggested that this incidence is not significant this is not quite con- ncing Gardner stated that experimental asbestosis does not predispose C tuberculosis Unfortunately the occupational occupational are not complete Ind _ histories of these Brit -- J. cases Med ia obs. rere i . . i ~ woe tote -< 4 - ee - oer Sry aa . H eb ne - : i rn a eevee eee ee ee ee : noe . week -. + laees { , } - ; . j : ot meee i nes5 . lam tafeete see i a wee) wee : ra ene - Tr i I. i ; } ~ ' ~ - ~ . ne . - H se - : . t,.e i see eae wae te : 1 mee= _- a - eee we cp eee meme i _ ed ~ \ ; comer te ie t t : i 265-7 265-7 | aarrHeme J. D. Hindley Some medical problems of the . asbestos FELLOWSHIP NUMBER - cement industry FILE NUMBER PA 468 ~,. ; DATE . anetR, SEF6.: wor. 468 DATE 120 | 50 a.a _ Brit J. Phys.Med MAR Occ Med . 1947 Oct. fy 468 _l | 147 - ee only two encountered no incipient cases of asbestosis and only author in five years experience in an PITSBURGH oarsbtehsrteoes ocfems entt afnad ctionrygschhorwoinnigctdhaitsevaesnetilation and enclosure were ade- A dermatitis occurring in some workmen was found to be caused by Cleanliness Cleanliness quate of the an abrasive constituent cement other than the asbestos INST UE and the use ofa barrier cream were effective in preventing it MELON ROT - +" srr DATE evam CEANING - tee cen = a ~~ Leah ER POFURSPEOASRECH CONT Cee - e7 FPG ayCo 388-8 an j # 145 145 rq. ' FILE NUM Routseny | . 145 One, L. om Title Rousseau tuberculcais 5 PA pulmonary Review, iy Title Asbestosis pulmonary Asbestosis Asbestosis Asbestosis and a pulmonary aesFrens Jf wn 4, ... G and Soiris Soiris g6 Pig . STATE mode may. A) : DATE ABSTRACT HET here,, B | E oo i Fay i French Quebec ie | asbestosis g } PITSBURGH B pneumoconiosis iB J. Med PITTSBURGH French PITTSBURGH ABSTRACT itn 7 Teyert frag o The authors asbestosis authors on PITSBURGH pneumoconiosieexpserimxents periments animal authors experiments They important pulmonary pulmonary asbestos asbestos pulmonary disagree not an important 1 factor tuberculosis that . statements Canadian Canadian asbestos | 5200 ad Apr. { } diagnosis of asbestosis tuberculosis Several cases ang asbesto- bedtes cases experi- op experi- eexpexri-peri-vo~ an eo" - result . - on on no asbestos bodies An An arce arce iinntto o which which which I I bestos bodies bestos were were asbestos asbestos bodies bodies in in in the the lungs lungs found found found sputum sputum sputum . : ! - - i et i : : fee es : room oa If If is see new om eg ot . atau lesion lesion lesion ren mousion injected into ed ed immediately im ediately immediately immediately considers that considers that the before before before presence as- of since -- it it it implies implies implies implies From From BBrit riBrit t tissue tissue damage damage J. Ind Ind Mod ae ate * we cc i . to. in. inc * t i { : : : . - i $ : eee a od . : ' i oF , : & 5 . Be cee . H on . c : ; - a : ! re ' eed re i : meee eee -: : . _ . ~ ae . !. - i : -- : i + : ' v ts tee e . te . booe oe : . 1 ' tee ge ; - + : ' ; 3 : t 2 - ry . . : ane room 8 " 4 ! ' 4 I i sweet cone mms perme eee : i ! H i H i i H i ^' ? . : : i i : f ~~ ; m4 oa . 5 . : : fe 1 ee eee eee i 4 ; : : . CLASSIFIED 1046-9 . 1046-9 | AUTHOR P. Luton and J. Champeix PELLOWSHIP PELLOWSHIP | FILE NUMBER - TITLE . Asbestosis . Pa ORIG NEFS VOL * DATE ASSTR REFS VOL DATE ll Arch Mal Prof. 7 365-378 JIH _ 91 .. Sept.147 Sept.147 | 1947 | 29 i ABSTRACT The authors list the following symptoms of asbestosis 1 Function- al signs 2 Radiological findings 3 Sputum characterized by the Pit^/snura ' presence of asbestos fibers and bodies After a presentation of several case histories and their accompanying ray films and sputum photographs it is concluded that diagnosis can only be made by a combination of ob- INST UE servations functional radiological sputum Because of the nature of the disease yearly examinations should be made with of the measurements of respiratory function spirometry etc. progressive comparison and rays But functional signs must guide the physician when a change of environment 6-4 MEL ON is advisable and when the worker can be said to have contracted asbestosis -- From J.I.H. ef teem oF -- - one re a ICM ae ees 1) swe emeemes 6 em eo: ~ we me ww Camere. mw we. eee. F PORM + , DATE EXAMINED EXAMINED , eee eee Lad) MAR From mm mw we ga ee soe: . - JTH JTH meee PURPOARCHI PURPOARCHI PURPOARCHI te ABSTRACT BLANK FOR GENERAL tte ae bee eee : UNI eee : CONT'DI ; :  CLASSIFIED SUBJECT | 1/50 1/50 a 736 So SST Te SRR sn BITS, Eel AUTHOR Cannon K.M. Lynch and W.M. vw . a Se Rn S222: .: TITLE Asbestosis VI Analysis of Forty Necropsied Cases iin FELLOWSHIP NUMBER Sinees es, FILE NUMBER - NFC = , Te wee 752 | wae . Pa ORIG RES re ee , Dia Chest + owe - a VOL PP T ------ 14 rey T =e BATE 1948 ASSTR REF6.1 | Brit J. Ind Med VOL DATE -_ 268-269 Oct.19 oo wer re e e ee mee Oct.19 Oct.19 The authors report an analysis of 40 cases in at necropsy. Cases are divided into minor which asbestosis was found, medium Pitsburgh of the disease and the prominence cases and advanced grades the advance of asbestosis bodies showing a direct relation to the duration of exposure. Grade pulmonary tuberculosis cases the primary 4 of 14 cases of advanced was of recent exposure cause of death. Only in Gardner's belief was recent for recent fibrosis that fibrosis In does not found this providing support progress of exposure. indefinitely after cessation Instiue Presence of asbestosis bodies is not invariable in asbestosis experimentally produced asbestosis. but is more typical of human asbestosis formation Lung damage occurs before the of asbestosis bodies represent an attempt by the tissues to which may be the lung indefinitely. Pleural fibrosis is segregate in segregate the particles they persist Melon invariable feature of an is an outstanding though not particles do not asbestosis;asbestosis reach the pleura, pleura. the reason for this is not clear as The occurrence in asbestosis of the fibrosis of silicotic type tally was confirmed in 8 which which King and others have produced nodular experimental out of 40 cases cases. Carcinoma of the lung occurred in three cases incidence of 7.5 per cent which is seven times EXAMINED STI OF SEARCH greater ~ | ABSTRACT BLANK FOR GENERAL USE \ at en . : i * ; years i worked factory 3 consecutive years i applying complained insulating applying applying applying respiratory mutonreicarlopsy asbestos nevernever complained compo lained f complained accident accident respiratory had 3 mutorimutorial al discrlors discrlors necropsy , necropsy worked in to articles aanndd h he e died the lungs the the - consecutive asbestos factory factory 22 fo. consecutive articles of died lungs lungs asbestos as were asbestos the result result of the a founfdound to thte he consecutive never complained streetcar streetcar Buring extensive asbestosis i extensive i between : described results the the results trouble 1 treatment INSTITUER 7 assistance material workerspropwhyloacrtickersprophylactic genraly Occ end economic particularly INSTITUER extensive extensive asbestosis features importance between gross importance results importance of assistance assistance rabostos assistance rabostos rabostos rabostos insulating material material attenatwiaornenesawsareness and awareness prophylactic prophylactic generally generally and generally wwoorrkkeres rs workers Condensed Condensed CCoonnddenesnesded from therapeutic particularly trouble trouble therapeutic treatment treatment particularly to Ind years years years complained . i } 14. te _ i . in d ~ those | Condensed Hyg OcMeed from Arch Med, from OARr Arch, amd. Occ 3 Ou. iyg, & Oce | 77 BCs Bare tt Minen, ov, 6 | . to, ees Fp seven eager /. DAISIFIED suesicer . Tr | ~ 149 867 AUTHORI Editorial and ce Tema I I C I I 471 471 . Cancer of the lung me of : lung o . C8. reve, . FELLOWSHIP _ FC liuMBER FC FILE g PA J-A.ma, Set ant {ee PO, 19 20 oar " ABSTR AgFS tee, Pir3sncr 1401219-20 Aug 15-49 and 867 Asbestosis Cancer of the Lung i Editorial ee . . | PP MUKIM B 13775E2R 137752 7s om - . . pare | IDUTE, ITUTE 2 C I: AMIELON Records of Report Records Records English English American and German Report English Inspector Report Chief of Factories physicians in 1947 show that the occurrence occurrence Inspector Inspector the lung is England related pulmonary asbestosis asbestosis . following This This supported by the relation is supported to pulmonary incidence rate rate supported in asbestosis observations 15 tires cancer cancer general high as population patients female female ratio is moraes evidence an among the general for the the female indicates ag nearly than evidently general population tended indicates that equalize the environmental environmental occupational carcinogen rate cancer of sexes Recent equalize the incidence support this the lungs for both clinical interpretation interpretation of Recent experievidence . clinical evidence, | \ Gare i EXAMINED --OOPPTTAARRCCIITTYY GENERAL \., Skee C 7/492217 ) 7/4922177/492217 7/492217 7/492217 7/492217/4972217 7/492217 7/492217 4, comet ere, 2 hae re 4 i neg ae n SR" 415 415 7 amis FC 752 AUTHORI Comorm Virginia The Title The Cost of Research on Tuberculosis in the United States Analysis of Allocations Pa Allocations in 1947-1948 Pa ORIG NESS | ORE: Meee VOL re. oe , DATE . . ANSTR Pays , 60 593-405002.149 593-405002.149 PITEBORou IA. m Rev. Tuberc Stew me ee ee 60 ee 593-40502.149 593-405002.149 593-405002.149 || . VOL PP np JATE ya ATE | PITTEBORou 1267 The Cost of Research on PITEBORou Tuberculosis Rer Allocations in 1947-1945 in the United States Analysis of Virginia Camoron Am Rer Tuberc 60 393- PITEBORou 405 Oct. 1949 , INFTIUTE INFTITUTE INFTITUTE INFTITUTE INIFNTFITTITUUTTEE C INFTITUTE C C Mel onMellon tae Mellon ~ Mel on " Mellon " outlined and The present research programs of various agencies are their contributions to research on tuberculosis are summarized outlined The total cost cost was 56.8 56.8 of account over six million dollars Official health agencies agencies tthe he total manufacturing firms 32.8 and the remaining remaining account for 10.410.4 is is universities supported by universities foundations foundations foundations and and voluntary health health agezdies agezdies agezdies agezdies agezdies commercial the Most Most of the commercialcommercial firms firms are manufacturers of ray apparatus or ; and pharmaceutical houses However other industries principally lilgihgtht heavy metal manufacturing and mining operations made a notable contri- bution ( 83,550 during the period designated for researchresearch on silicosis | Fifty percent of and tuberculosis tuberculosis this . amount was 77 - aa wee a Foi : PURPOSE CONTO pec DATE PURPOSE nh oe ro oo +e tee eee : : ae . o : . : on . Foi EXAMINEDI ... OF LEARCH { ABSTRACT BLANK FOR GENKRAL USE _ ( a} aa 77 TORM . CLASSIFIED SUBJECT 11th 50 ~ The a FELNULMOBWERSHIP | | ie NFC FILE NUMBER AUTHOR H. Ollivier P. Morand TITLE Granulomata of the Skin Due and R. Brun to Asbestos _ PA ORIG RE71 VOL ABSTH Arch.Malad Arch.Malad Profession- Profession- PP 516-5171949 DAYZ 516-5171949 =f REFS Bull Hyg 25 VOL 25 1482-485 1482-485 1482-485 516-5171949 nelles ) 10 110 1482-485 A Mee eee hand A man who slightly was working with Two weeks asbestos sheets wounded the palm ome of his Pitsburgh which was later at the site of the cuta swelling increasing in size appeared There was no the swelling was hard at the center inflammation and The small white nucleus of this core was seen under the together with a mass of microscope to be composed of needles of asbestos as crystalline matter This matter was identified cholesterol which formation would seem to indicate INST UE biochemical defensive process of the a fundamental and body against aggression by asbestos 1482-485 DATE May 1950 + ee ee ee -- Condensed from Bull Hyg - c) Melon se mem oo _ stem ee em ose ee emma ge te se me ate er ee ee ee ce we ee - - ee 1 ee mee we NN esete te Soe tem tem + eS ae nee we et 8 tg. ose ate - en TA ree Sie eee mmr emare 8g eaten ce eee 6 eye eee cee ece de we eee nm oe tearm An ewer F648 TS mT E er mm Om Bem es cd emmm eT 6 ek ce ns ne or owe a _ - ee DATE P41) 4-3 e . e Leeee ev: : : m ~ ee PURPOSE OF SEARCH see se 8 ae eee . wee . eo +o CONTO CONTO ABSTRACT BLANK FOR GENERAL USE ee pe < i 548 548 < 548 , - ' - | < . ; toni . ete ey! oe ha ra TELLOW : i FILE NUMMER i ~ : NURSER i 2 ! i 2 ! ' a . AUTHORI P. Cartier Cartier * NFC ; 752 Pa FITI.E A Contribution to the Study of Asbestosis _ URIC REF6.1 te ee oe Arch Malad Profess Arch Fr. 89-595 1949 Ind.Ryg ) VOL 89-595 10 Pe. 89-595 1949 1949 | AESTR REFS Ind.Ryg ; Occ VOL . Pr CATE i $ Hl AF Mod 3 The author has been in 423 4/52 4/52 asbestos mines in medical charge of 3,242 men Canede where employed in PITSBURgn asbestos is mined Cases of over 70 per cent of the world's supply of _ been employed for at least 14 asbestosis were found only in these who had 5 million particles of years snd exposed to air containing at least 10 to 250 microns in asbestos fibers per cu ft the fibers being from mildness of length The outstanding feature of this any pulmonary trouble among the asbestos report is the INST UE reported in the United States and Great miners compared to that ems where asbestos is Britain as occurring in factories were present spun and woven No case of No clinical symptoms of pulmonary fibrosis and no physical pure incapacity was asbestosiwass detected in those under age 60 evident Cases of tuberculosis were not more MEL ON tfhreequent among the miners than among the clerical staff and the community although that incidence was rest of ascribe any cardiac affections high It was difficult to age at which it appeared present to asbestosis because of the Postmortem findings and late examinations indicate that asbestosis is roentgenologic the miners it develops so slowly as a pathological entity but among is no evidence that it not to shorten working life - there . " predisposes to tuberculosis by are supported the opinions of experts at The conclusions ~~~ reached Suranac -- Cond from Bull Hyg Sealed Se aa nae ee aw . tr - $my . 1 FORM FORM . Bull DATE Postgraduate Med JJ J.. 5)658Dec. = Hyg aa Asbestos shown and tale are the only twosilicates which have been to : produce pneumoconiosis Gardner in 1938 suggested on the basis of animal | experiments that the effect produced by asbestos was mechanical since it was produced only by long fibers A later authority made the observation that workers exposed to very short asbestos were not affected by it As- bestosis was officially recognized as an industrial disease in 1930. The ~ = condition is thought to be due to blocking of the finer bronchioles by long> fibers which seem to irritate the branchial wall and cause fibrosis Tubercu- losis and carcinoma of the lungs may follows as complications Recognition , of the disease and precautions which have been taken have lessened its 7 severity and incidence -- Condensed from Bull Hyg : on we ee te nn Pa ee ee Me em a een, ome cee ent en | puemninne ae tee e n e ee ne ee a pe am ree ee eerie re ee, mews 8 eee owe gem fms a ee eee Ren 8 Ne Gp OR eS mee eRe oe nee eons te. aoe PURPOSE . evs OF SEARCH , : H ' 3 : ABSTRACT BLANK FOR GENERAL USE . . " ( iy . . oo 123 ILD SUBSECT . 1142 1142 Th Th : ; Th ee #IC : : FELLOWSHIP i NUMBER NUMBER HUMBER : : H : : <5 summum J. Champix and J. Bouteville ese. Electron Microscopy of Asbestosis Bodies and the Fibers Asbestos Pa CF CFS S vet P Puli Maladies Maladies Arch Profess 11607 11607 seam DATE NUS REFC REFC ' 1950 |i Brit Ind.Med YOL FP : 8| DATE 17/51 19817/51 MESET t- Asbestosis bodies recovered from sputum have a central fiber of j' asbestos coated with a colloidal gel which is probably protein MES T Removal of the enveloping gel by micromanipulation reveals MESETMESET of the edges of the asbestos ' Fibers shorter than 10 fiber some transparency believed to result from solution microns are not found in the bodies and it is ' suggested that the smaller fibers dissolve completely On this evidence Towerinta . the authors suggest that pulmonary fibrosis may result from solution of Towerinta asbestos rather than from some physical irritation -- Brit J. Ind Med Mundo CATE . aserta, BY 11197035 UUF 90.49Chi 90.49Chi AbalGACY NA FOR POtM ey cg . CONTCOO NTO wu ee . Se Rete ek. bd ee En see ee Oe vee cement eee CLASSIFIES SUBJECT 152 AUTHORI A. Bohme . | FELLOWSHIP | FILE NUMBER | TITLE Pa Results of Periodical Examinations of Workers in an Asbestos Factory German 1 26 German Hyg ORIG REFS Beitrage z Silikose -- Forschung_ VOL PP 11 27/34 DATE 1751 . AGSTR EFS Bull Hyg VOL ce 511 j aw. DATE 5/51 ar i PITSBURGH Since radiological supervision and a oe in an asbestos factory in 1936 control measures were adopted the dust hazard has been as shown by comparing results of greatly reduced comparison of surveys in 1936 1940 and 1949 A in spinning and different working places shows that the risk is low weaving but high in polishing A table shows results for preparation carding and brake | others not 14 cases from 1936 to 1949. progres ed INST UE did - Inquiries among Some any tendency to progression after former workers reveal little if the dust exposure has ceased This is in contrast to control On the other hand in silicosis as a number of a personal factor exists as MEL ON high dust exposures workers do not get asbestosis in spite of _ Progressive tuberculosis both started in the parts of is rare only two cases being the lung least affected by asbestosis found ax05{ combination of asbestosis and carcinoma of the One of this study is the demonstration lung was found The main result M OJ silicosis that the hazard can be reduced by dust ' --Cond from Bull Hyg four x, os o ~ of A | Sat f. WHS eee ses. 426 = W. Behrens AUTHORI Pa, > Behrens asbestosis P eek . a = 0b eee a FELLOWSHIP NUMBER , 1 NFC Fi MUM Ar . w .. NS Pitsburgh Schp weia z.zt .alh lg Schweiz.z.allg | 14 275-97 1951 Bul Bull Hyg __ , . 261181 12/3 or oe r Pure mee. 7 ot chrysolite asbestos Ss tracheally Pure mice and was injected injected intraperitoneally ~: tracheally Unsuccessful 3 rats The fibers microns in attempts attempts to varied standard standard length length are in ~~? length Unsuccessful general secure fibers standard focal : picture is one of fibrosis are INST UE, described from the introduction introduction of specific solution toxic resulting resulting from asbestosis asbestosis could be foreign bodies Asbestosis Asbestosis bodies were demonstrated formed asbestosis Cd The theories of discussed the pathogenesis of discussed MELON . from Cond from Bull Hyg Hyg. . ~: Cond from Bull. . & see x . - DATE 6 a ad) o SEARCH ABSTRACT ABSTRACT ABSTRACT BLANK FOR GENERAL USE CONT'D. cee wo & ttreomen oo t C , () CLASSIFIED SUBJECT : . | $ 2 | FELLOWSHIP NUMBER FILE NUMEL 100 AUTHORI R. Stoll R. Bass and A. Angrist 752 Title Asbestosis Associated with Pa Bronchiogenic Carcinoma ERIG REFS Arch Intern Med 813-4 ._ In Berman 881831-834 51 27 444 _ VOL 881831-834 881831-834 881831-834 881831-834 881831-834 8 1831-834 881831-834 OATE we Le Dec. AOSTR h- e7 . REPTI oo Bull Hyg me ne ee ee ey mere. SRO ~ a eo ei: mmr meee we. tee me VOL . 27 . . ee ae CATE Pitsburan 15-52 found carcinoma in 7.5 to in which a worker had 14.8 of cases of asbestosis A case is reported been exposed to asbestos for 6 ~ Instiue years and had refused MEL ON metastases After death modules scattered throughout both varying to 4 cm in diameter were found lungs with interstitial fibrosis Large areas of ninescirdoesis existed throughout the lungs and typical asbestos ; and outside the tumor bodies were seer brain and liver areas The opinion is Metastases were found in the kidneys suggested that the silicate in Eventive itself be directly carcinogenic It establishes asbestos must Eventive measures in the use of asbestos an additional reason for pre- DATI 3As ABSTRACT BLANK FOR GENERAL USE -- Cond from Bull Hyg ~ am ce ee i | AUTHORI AUTHORI J. Clerens Mowe CP Oe te a Ttem FILE NUMBER ITLE PA Research into Pulmonary Asbestosis Asbestosis Asbestosis in Belgium GRIG REFO.I were Arch Belges med ! el sociale hy el PITSBURGH ABSTRACT . VOL pp 1557-565 1557-565 12/51 PATS nee a 1 ADYTA QfFg 8 1557-565 1557-565aultravilet 12/51 aultravaillet aultravaillet and legale Bull Hyg legale . . . . 4 i bee cae nL.oe PP , 26 | 402 [ hoe i The investigation concerns the cement industry in which asbestos is crushed and mixed with INST UE prevents most of the dust cement Enclosed apparatus INSTITUTE 20 to 40 from escaping escaping in the most dusty locations million particles INSTITUTE 5 microns The workers p haevrecubbeiecn foot were found with 50 under aoe of three years examined Out of 75 men periodically over a period employed for seven to thirty there were four doubtful cases and over years Melton . indicating pneumoconiosis The manondliyedonoef presented ray shadows Lt circulatory insufficiency and details of progressive ae - mortem findings are given ee DATE 4/51 4/51 ee oo NlSTeee UATE EXAMINED EXAMINED . At PURPOSE von OF SEARCHL ABSTRACT BLANK FOR tee GENERAL USE we - CONT'D esas ty 8 wee eee. ae os th peeme coiren erp ne . ieee . we Indurated Indurated cement associated Indurated nodulensod au ndles asbestosis bodies ~~. asbestosis bodies were found ve. oe) lungs but no tubercle bacilli bacilli bodies The throughout the in the alveoli and bodies were seen in in fibrous ~ aged 49 had been even included within giant phagocytes zones This e totally incapacitated with man dyspnea on exertion and 12 failure In others asbestos particles samples of sputum and asbestosis were found in 10 out of findings were not associated bodies in 3 samples but the | _ The with ray shadows evidence is against much indicating fibrosis danger arising from the manufacture of ee ee te. pee t : cee Tee ee he -- Cond from Bull cee from Hyg . id . 4 : 1 . : : ' H . t . : : 3 , 4 : > i - t ' i : | i : * * i ; : . + s_ ews wees meee te. . Seem ee -- . : : . wee rrr ry en 7 : TN : , : os a scene seen, - fs ewe tc w ee ee ae . ot : eee : t ; . > . caot Ae ane woe tet ear . mee ~ Soe pe a CLASSIFIED SUBJECT a d ne Fle he eee, fats ee aS) [Lo 5 eee he 8 ONS SE Se: eat Tenner le tee an he oT FELLOWSHIP NUMBER FILE | nfc | 752 Ee Sat Ve ctnine atin... wl , NUMBER ee . AUTHOR P. Luton J. Champeix and P. Faure PA PITSBURGH 5 o~ MELON TITLE A Case of pulmonary asbestosis with Its development followed by _ mortem study ray and its ORIG REFE VOL DATE - men mee ne weeeee PP Arch ~ maladies professes629-33 629-33 1951 | ASSTK REF6.1 ---- mee Bull HygHyg VOL DATE peo 942 27 942 10-52 10-52 | | |~ The case reported is said to have been the first one of asbestosis known to have occurred in France The man had been exposed to high con- centrations of asbestos for 11 years Symptoms and progressive ray find- ings are described After death the lungs showed general thickening through- out especially of the plurae but with no localized nodules Many asbestos bodies were seen isolated and in groups together with giant cells and min- eral particles No evidence of tuberculosis was found The dust particles could be traced not only in the lung vessels but also in the vessels of the liver kidneys and spleen The action of asbestos is apparently mechanical rather than chemical ee one eS . ti ee oy -- et Se Ce oe nd from Bull Hyg DATE _EXAMINED _EXAMINED _EXAMINED _ Bre ee ; dee A tees pees wee : : hood ae . PURPOSt . OF SEARCH ABSTRACT BLANK FOR GENERAL USE CONTO ce bi Ait ve pee pen ee eget cnenenemes ee a RG copay tere oe! ree eee Qo ( ee eee e+ CLASSIFIED SUBJECT Fou 218 FouFFoouu + FELLOWSHIP NUMBER | NFC . PILE NUMBER 752 AUTHORI P. Lepine and O. Croissant + TITLE A morphological study with the elctron microscope of particles of . Pa asbestos found in the air ONIC REFS VOL PP . DATE Ann InstPasteur 80305-8305-8 [3/51 oo ALSTR RE79 | Bull Hyg VOL DATE . 1000 1000 10/51 26 wT. asSee . _ Pitsburo Six samples of airborne dust from workplaces in Quebec where asbestos is used were examined with the electron microscope after removal of all but the most minute particles The dust was found to con- tain crystalline needles smaller in size but similar to those seen in an ordinary microscope these needles comprised 65 to 75 of the particles , Instiue The remainder consisted of amorphous particles mostly of serpentine The needles had a diameter of 0.028 micron they occurred in bundles about 0.85 micron or more in diameter Such particles could readily gain access to the alveol and undergo phagocytosis with formation of MEL ON the tissue lesions seen in asbestosis Photomicrographs of the particles , are shown . > Cond from Bull Hyg . . one . te woe . wee a Yr a 71 71 FORM FORM DATE EXAMINED . 34) oe : . : . PURPOSE OF SEARCH ABSTRACT SLANK FOR GENERAL USE CONT'D eee . K gers +t t t { { C C C os an st i : 54 wee ko 54 nn 2 <1 ( t hrs | NUMBER FELLOWSHIP FELOWSHIP SNe ee, oon | FELLOWSHIP ~ FILE NUMBER Reubens study , Heater eee, = nfc 752 AUTHORI H. Bastenier H. Denolin A. Decoster and A clinical and R. TITLE pathological of a PA case of pulmonayr asbestoses PA ORIG NESS ; Lo, a Murou wae. VOL Pr CATE ABSTR REFS.1 Arch beiges med 61-70 sociale 10 lega med Murou sociale hyg med . travial et Feb. 52 . a VOL | 1126 Bull Hyg DATE French 1126 med legale Murou 12-52 A diagnosis of asbestosis must depend _ a ne exposure to asbestos dust associated upon a history of occupational case is reported in which with effects on the respiratory organs A a woman had worked for 25 a factory with heavy dust exposure The years weaving asbestos symptoms authors compared this case with described are typical The residual air is those of uncomplicated silicosis in the latter frequently increased expiration is respiratory capacity is reduced but prolonged and the maximum hyperpnea intense and anoxemia is rapid breathing is not so differences never so important during effort as in asbestosis These are stressed as important when the occupational origin of a case with obscurneecdeisasgintoysimsay arise in determining M ; M , er OBE T . -- Cond from Bull Hyg 27 FORM DATE . FORMFORM [ EXAMINED BY PURPOSE OF SEARCHI ABSTRACT BLANK FOR GENERAL USE CONTE ' - e a Pee nag ae semen ne gtr CLASSIFIED SUBJECT SUBJECT Z FELKLUOMWBSEHRIP FILE NA AUTHOR W. Behrens Jr. -- Lm . . TITLE The clinical picture and pathology of asbestosis e Pa ORIG REFS ae Unfallmed u Berufkrankh -9-0126 -9-0126 -9-0126 -9-0126 -9-0126 DATE June 15 1952 ABSTR Rero Bull we 1927 Hyg , 1927 3-53 3-53 ABSTRACT ee - 179-84 Sept. 3-53 15 1952 . This paper presents an extensive revierwevoi few literaturleiteraturo e n 3 asbe- stos5 is 3 Pitsburgi including distribution and types of asbestos its mining treatment dust hazards and effects of length of exposure of the dust and use in different con- centration Symptomatology diagnosis and ray findings in the different stages of asbestosis are described Special is of asbestosis with mention made of the association carcinoma which is much more frequent than that of sili- cosis mortem reports from the Instiue of asbestosis there literature indicate that in 309 cases were 44 lung carcinomas 14.2 whereas in 2,204 cases of silicosis only 32 carcinomas were found association of 1.4 The experience of the , tuberculosis and asbestosis varies greatly in different countries MEL ON English investigators have recorded a high rate of tuberculous asbestos workers but it is a infection in rare complication in America and the rate is low in Germany The macroscopic and microscopic 32 77 described and the nature and appearances of the lungs are significance of asbestosis bodies are discussed . FORM reference dealing and an extensive list with that controversial subject is given ~ F mmm ee . -- Cond from Bull Hyg _- = wee CLASSIFIED WEST , / 7 75 33 oom em mee ene an oe em re ey s ee = | | AUTHOR M. A. Kovnatskii and others eres FELLOWSHIP nfc | Tv FILE NUMBER { 752 TITLE Silicatosis etiology pathogenesis and clinical treatment P^ ORIG RE76 - a se VOL tee 28-32 GigiieSn ana it -- Russian , No. 8128-32 28-32 : ome . DATE 1952 me ASSTR REFS Chem Absts VOL 461140002 461140002 PP.. 461140002 DATE 114000112552 A - A review is given of the disease caused by particles of silicates rather than those of the type producing silicosis proper A study of the Pitsburgh disease caused by asbestos particles showed that the chemical and biological features are increased rate of respiration compensatory and in stages the level of blood saturation with oxygen is essentially normal although changes in the myocardium are evident on the electrocardiogram The tone of the veins is reduced and the permeability of capillary walls suffers a decline INST UE in a considerable number of cases This affects the oxidative processes as shown by the increase of oxidized glutathione and a decrease of total Melon glutathione . : a rem e Tp em ns cet : cme eh mee ee ey e - o- e- Chem Absts . . Lee eet . ee ee we Ree as 1 te met em pte perme ce tees | we coum te me : ; a - . -. Le . DATE EXAMINED EXAMINED EXAMINED Le. BY: ewe ee. . . . PURPOSE te , OF SEARCHI : ABSTRACT BLANK FOR GENERAL USE . CONTO : ae] | Lape cae J. Ruttner ~ Be EET Loe Asbestosis bodies and asbestosis bodies | PAI PAI | SchwZe . i Allz gem 15 628-31 1952 Bulll Hyg 28719 = Sept. : 28719 Sept. German PITSBURGH Pathol.u Bakteriol -.. aay The literature on asbestosis bodies is reviewed Similar products Se contained were found by the author in a lung which only carborundum and | PITSBURGH formed around the bodies were plates and needles of carborundum graphite The protein and iron which form the bulk of the bodies must come from InST UE the lung tissues and not from the mineral matter of the dust Similar bodies could also be produced in vitro but they have not so far been found - in animal experiments | -- Bull Hyg pet ag ? FORM f N ' . Melon . an a ee esas eet ete eee emcees wen meme ene one eamame srr ne ce) . DATE 5 EXAMINEDA ax PURPOSE SEARCH ABSTRACT BLANK FOR GENERAL USE i} ' cf stem emer wee { e*,r C ~ ( 17 FORM i 1/1 1/ FELLOWSHIP | NUMBER FILE NUMBER P AUTHOR A. J Lanza TITLEI Asbestosis : . Pa Paper read before Fourth Conference of McIntyre Research Found on Silicosis GRIG REFU wn 112 112 VOL 112 Bfi, DATK ASSTR REFS | VOL atl ay. DATE 12 PP 1/1952 ii aw pointed PITSnurg Britain briefly reviewed The action of asbestosis on the body is It is out that asbestosis is than in Canada or the regarded much more seriously in Great United States the British believe it is worse inst uE resulting than silicosis and often leads to cancer while from asbestosis is practically existent in America cancer Melon e S O DATE PURPOSE ABSTRACT BLANK F^ R GENERAL USE CONT'D .. sem = ( \ eS , , | CLASSIFIED SUBJECT TT | 6/3 6/3 6065 05 | AUTHORI F. Boemke | tS . S eee Sie. Sat Set a . EE Sete ee. 2 eS FELLOWSHIP | NUMBER FILE NUMBER nfc 752752 sa _ =. TITLEI Lung carcinoma caused by asbestos inhalation _ Pa a . Pa ORIG RES VOL PP aoe DATE AESTR REFS.1 DAT || 1471-55-105 1471-55-105 PITsnurgi Med Monatsschr 7 77-81 1953 ChemAbsts PIT snurgiPITTsnurgii tl changes PITsnurgi German The relation between fibrotic changecs aused vee) eee vee eho by asbestos deposits PITsnurgi lobe in the lung and carcinoma is discussed The lower is the site of pre- PITsnurgi dilection Characteristic are the multicentered developments of flat epi- , I thelium carcinoma -- Chem Absts C ac ac ar t og a Institute Mellon |) Mellon |! Melon | Mellon o eens . _ . _ : l DATE EXAMINER EXAMINER on aimee . a ha - oe eon ' ry : cal - ee re : PURPOSE OF SEARCHL See ABSTRACT BLANK FOR GENERAL USE , CONT'D . CLASSIFICO SUBJECT # i FELLOWSHIP | | NUMBER FILE NUMBER TITLE Asbestos warts and other dermatoses in workers with lagging materials Pa ORIG REPU 22 1-17 Jan Jan DATE AESTR REF9.1 ; woe. 22 | Jan Rass med ind 1-17 Feb Bull Hyg VOL PP. 28 953 | DATE Nov PITSBURG^> The author has investigated cases of warts on the hands of 29 workers with lagging materials including asbestos cord which is wound around pipes various containing slabs and mixtures of asbestos and cement to be molded to the shape of the tank or other object to be insulated One to four warts were found in every case They are due to asbestos fibers which INST UE penetrate into the epidermis and become lodged in the corium or true skin The epidermis shows acanthosis thickening of the prickle layer and hyperkeratosis increased horny tissue and the corium shows a granulomatous type of reaction with the appearance of giant cells in some cases MEL ON Exudative dermatitis may also be present This condition is attributed to the combined action of the hygroscopic and alkaline cement and the irritating asbestos fibers The gross and microscopic appearances of the lesions are illustrated -- Cond from Bull Hyg DATE EXAMINED BY, PURPOSE . OF SEARCH ABSTRACT BLANK FOR GENERAL USE CONT'D J ve eee ee CLASSIFIED SUBJECT . me . Le se 1 om i 550 y| | 550 Pe te St = ama. . S. AUTHORI A. Ramaswamy aa. D. S. " Ohh Venkatesh FELLOWSHIP NUMBER al ating TE | nfc RR aft nfc nfc beer and R. Rama Rao FILE NUMBER 752 or * cee Fe | e TITLE The nature of lesions caused by asbestos and mica in experimental Pa pneumoconiosis in guinea pigs OFUG REFA J. Indian Inst | ee Sci ~ YEL te, 35 1319-31 Sect Sect A DATE Oct. 153 ARUTH REFS Bull he . Hyg 172 129 DATE Feb'54 pigs Guinea were subjected to intratracheal mee injections mica and and ee of mica and ee PITBUran asbestos dusts Stress is laid on the development after long periods of lesions in other organs besides the lungs especially in the adrenal glands Mica dust was found to lead some degree of nodular formation in the the asbestos dust lungs but set up diffuse fibrosis only These differences are por- trayed in series of photanicrographs Mica induced hypertrophy of the ad- Instiue renal cortex with extensive foamy disintegration of the cortical cells asbestos induced lesser changes but small areas of necrosis in the were occasionally found zona fasciculata and zona reticulata In a theoretical discussion the authors attempt to draw a relation between the atomic structure of mica and MEL ON asbestos and the pathological lesions in the lungs and other organs Their theory theory however leaves many points unexplained from Bull Hyg nine ~ ~ ste a ee e S DATE | , : a PURPOSE ? - DE SEARCS H EARCH ABSTRACT BLANK FOR GENERAL USE - a CONTe' reD me MN . TR cae tennis amie No ene nag Rn ayes - CLASSIFIED SUBJECY , : 8-54 905 905 905 us : | . FELLOWSHIP FILE NUMBER nfc 752 AUTHORI Wyss V. . mee . rr m6 TITLE The presence of asbestos PA fibers hazard : a. inurine of workers exposed to asbestos ve nee ORIG REPEJ 55-56 _ Rass med ind VOL 22 55-56 DATE ABSTR nore: ~ Biol Absts A a 28 DATE | 1953=| | July'54 Italian _ ASGTRACTo. In urinary sediment of two asbestos workers asbestos fibers were seen PITSBURGH the same finding was detected in urine of two female patients suffering from as- bestosis who had left their work seven years before -- Biol Absts _ INSTUE MELON a ec ee - eee - +e eee DATE STAMINED wee BT. : Let et eee 2 i . . : a a PURPOSE OF SEARCH ABSTRACT BLANK FOR GENERAL USE ean - & . CON CONT'D . T' . D =a Rn aSpeake Ss,es siting Petite cnaiiiat ae oSoEowar tyvated lene!Sear aiessi deed EAN Sopa aarte Se dagen bs eee a Experimental studies in metalcancerigenesis 6. Tissue reactions in rats or rabbits after parenteralintroduction of f suspensions of arsenic beryll f NatlCancer Inst.15 Inst.15 113 121995) 4 Chem Absts Stee. ee 48 13043 10 - 55 _ Experimental Studies in Metal Cancerigenesis 6. Tissue Reactions in Rats and Rabbits after Parenteral Introduction of Suspensions Arsenic Beryllium - or Asbestos in Lanolin W. C. Hueper | J. Inst 15 113-129 1954 ( Natl Cancer beryllium When powdered arsenic or asbestos in lanolin was paranasal injected into the marrow cavity of the femur pleural cavity or ee sinuses of rats there was no development of any significant number of aon - oe cancers either at the site of deposition or remotely causally related to the the chemicals introduced Similar negative results were obtained with the lanolin alone The sarcoma attack rate at the site of the injection for _ na 250 rats used stands at 0.8 contrasting sharply with that of 30 for = rats injected with nickel suspensions and 20 for rats given parenteral 2 ae me ee wee am de ee ee % FRANINDI W PURPOSE SEARCHI ee ; ABSTRACT BLANK FOR GENERAL USE (over cee An A em EE ERE Fae AER OREN Ee RE MEM G Or RIT BRR cme nm grt gpm a mnt CLASSIFIED SUBJECT , 1249 12/54 1249 12/54 1249 1249 12/54 12/54 = 12/54 Rene AUTHOR J. Krausler and R. Seyss | TEE NES i mayne : FELLOWSHIP NUMBER | FILE NUMBER The Early diagnosis of asbestosis by enlarged radiographs PA PA ; RGH ORIG RES German VOL __.. ow. DATE ABSTR REFS.1 ; VOL - re DATE ROH Unfallmed u o Berufskrankh 59-64 Mar15'54 47 Mar15'54 Bull Hyg wee eee eee 29829 298 29829 | 8/54 ~~" a After a brief description of asbestosis and the changes in the lung tissue in the early stages the authors describe a radiographic technique with a fine ~ focus of 16 asbestos workers with 1 to 18 years exposure eight showed changes in the lung tissue with the enlargement technique two of these showed no change by normal technique and in minimal ra sews 1 eee -- the other six cases the degree . of change -- Cond + . te shown was from Bull Hyg -Ce-@, MELLON MELLON | MELLON | MELLON wrine aoe - cee ee- oe OO ee me at ge ve a i ot a. or as - ee re ae . - _- 4 ag. 77 FORM | ~ DATE EXAMINED ~ ; 7 cae Lenka ee eee 8 PURPOSE VI OF SEAREN ABSTRACY BLANK Fok GENERAL USE CONTO cee CLASSIFIED SUBJECT a/ . 1032 | | FELLOWSHIP j NUMBER . FILE NUMBER Li AUTHORI J. F. Knox and J. Beattie . 4 . || TITLEI Mineral content of the lungs after exposure to asbestos dust c om H 17 FOAM PA ORIG REFR VOL rr, DATE AGSTR REFS . VOL SE 9 fe on areen DATE 10 | | '54 IBURON Arch IndHyg & IBURON Occ Med & 23-29 July fi | _ IBURON ABSTRACT . soe . woe. 3 7 . m ae _ a_ The mineral content of the lung parenchyma the lung hilar region and the tissues of the pleural and subpleural regioinnsdustry lungs from 27 workers in the asbestos of the lung has been determined in The exposure time varied from five to 33 years and the time interval between the last exposure to dust and death survival time was from less than one year to 21 years There was an indica- tion that the mineral material found in the lungs increased in amount as the exposure time lengthened The amount so accumulated varied considerably from person to person As the survival time increased decline but again at a very variable rate the mineral content of the lung tended to The severity of the asbestotic lesions in the lungs found at death was related not to the mineral content but to the sum of the exposure and survival times -- Authors summary a rr) . CN nt CD a8 fom ee cee ee Sr, aed Ort wie DATE foewtry 2-" yi. PURPOSE _IE_SEARCHL _IE_SEARCH_IE_L SEARCHL ABSTRACT BLANK FOR GENERAL USE | CLASSIFICO SUBJECT | abd LOd Lud | FELLOWSHIP | | NUMBER f nee fc FILE NUMBER 752 a ~ AUTHORI J. F. Knox and J. Beattie and fibers in the lung after exposure to of mineral particles TITLE Distribution PA asbestos dust VOL 30-36 July DATE ; AGSTR RE79 VOL Sted DATE we ORIG REFI.1 , Baurgh Arch Ind Hyg & 10 Med 30-36 July ; ee a . Occ insoluble . Baurgh . incombustible and insoluble ABSTRACT in the incombustible were Baurgh distributions " The particle had been exposed to asbestos dust residues from the lungs of 27 persons who in excess of 26 microns residues number of particles with greatest lengths asbestos dust and determined The after the last exposure to 7 was considerable up to the eighth year the size ranges of five microns { within The number of particles long period then sharply fell remained constant over a very and less and between five and 15 microns minimal fibrotic change The of asbestosis or of such particles < in those cases which showed no sign rise in the numbers as asbestosis showed a significant with the production cases of severe mechanism which is concerned of Ne It is considered that the is responsible for the production a asbestosis is not the same as that which concentrations of asbes- of human animals exposed to high of experimental asbestotic changes in to be related to the breakdown of such changes seems ~ tos dust The appearance some fibrogenic agent . ~ ~ Cy v asbestosis bodies which may liberate -- Authors summary - 77 7 : FORM FORM - V016 CXAMINED . or Chal ~ FURTUBS OF SEARCHI FOR GENERAL USE . ABSTRACT SLANK a CLASSIFIED SUBJECT 855 mee. | FELLOWSHIP NUMBER NFC ian FILE NUMBER AUTHORI TITLE Primary F. Leicher inin case of asbestosis cortical cortical tumor of the peritoneum Primary - Pa 382-382 ORIG REFE German . vol. 131 Arch Gewerbepathol DATE ABSTR REI : me 'e DATE VOL Pitanuro following long Gewerbery Gewerbery of asbestosis following exposure to asbestos is case described In addition to typical symptoms and findings leptomeninfound in the spinal fluid gitis was present and tubercle tubercle bacilli were tuberculosis of the Pitanuro died with cachexia Autopsy showed The patient with bilateral psoaspsoas abscess and mixed infection in both . definite fi- lumbar spine was foundfound in the lungs with Asbestosis stage two lungs asbestosis in the lymphatic glands and asbes- brosis there was slight of the mesen- Instiue tos bodies were found in the spleen On the peritoneum thickened patches and and over the peritoneal cavity there were were tery small nodules a flat tumor half the size of a hand and 1 cm in under side of the dia- many was attached to the peritoneum peritoneum on the thickness The results of the examination of the tumor are fully describ- Melon phragm was found in the tumor tissues by ray ed and illustrated Asbestos Asbestos cav- a ^' diffraction is uncertain how the asbestos reached the peritoneal of ao route route was thought to be by direct penetration 40T*D eae ity the most probable and thence through 77 fibers from the lung through the pleurapleura the asbestos FORM the diaphragm pene cee y weyinsce cae Smrnsnmer oso Digest sees < i i a . CLASSIFIED SUBJECT : FELLOWSHIP | . FILE NUNSER | NUMBER WHE TT.. T. et ood m+ 6 } ( r~ a A 77 FORM AUTHORI Queries and minor notes JAMA TITLEI TILEI TITLEI Asbestosis Pa ORIG REPS.L VOL BAYE AUSTA REFS | J. Am Med Asso 156 1546 18'54 VOL TT see emer T eee T : aee mame otf PITSBURGd insulation awe -A 50year man worked at covering pipe with asbestos from 1940 to 1945. The question is the possibility that pulmonary fibrosis ' evident on roentgenograms in 1952 was due to asbestosis when the films had been normal in 1949. The answer is that the cause of the fibrosis must be sought among other sources than the 1940-45 occupation Little evidence INST UE exists of progression of asbestosis after cessation exposure to asbestos fibers Moreover exposure would have had be much more severe than in the man's occupation in order to produce asbestosis and it would have MELON manifested itself in the 1949 roentgenogram tl MEL ON DATE EXAMINED EXAMINED | an A AA 7 " PURPOSE OF SEARCH ABSTRACT BLANK FOR GENERAL USE CONT'D CONT'D . 0 a - CLASSIFIED SUBJECT 3774 3774 2601 2601 2601 Ree =r ee seme : FELLONUMBEWR SHIP VILE NUMERI AUTHOR G. Jacob and H. Bohlig mas Incidence and characteristics of lung cancer in asbestos workers PA REVB German VOL Arch Gewerbepath 1410-28 1410-28 BATE ITH REPS.I 1955 . Bull Hyg vo... - 30 DATE 1080 12/55 t tee PITSBURG Gewerbehve +. This is a study of the incidence of lung cancer among asbestos workers in Dresden ; The international literature is based exclusively on the results of autopsies the incidence among asbestos workers appears to vary between 12 and 17 research into cases at the clinic and among asbestos workers In Dresden however fram it appears to be rare it be- ing estimated that only about fourth of these workers have an effective exposure to the dust In cooperation with the radiological and radium institutes the authors reviewed the cases of asbestosis reported since the middle of the 1930s These numbered 339 in all males stages they are classified according to stage and sex . Silicosis was found in eight INST UE the In five females and tenjmales 4.4 of total active open tuberculosis was found Four - fatal cases of lung cancer in asbestos workers which occurred in Dresden up to 1954 are described A long discussion of the literature on cancer among asbestos workers includes an examination of the characteristics of the disease these are no longer convincing evidence . of a high incidence of cancer in asbestosis In the future cases of cancer of the lung in MEL ON s asbestosia should not be published individually but should always be considered in the frame- work of the whole asbestos industry in the region -- Cond from Bull Hyg . sm mesnee- : owe precede A - _~ s mpees re . : ; : . . : ow * arn . t or) . , or a: eeee . 6 a ee So . i- . . e Boe w+ . mee cam i : . EXAMINED PURPOSE SEARCHI ACU DATE vm | _ : i STRACT BLANK FOR GENERAL USE | Df 1/56 . 4 Aron, R. 5. Speirs and U. Wenck PA THTLEs - Local inflammatory response produced bestos type filters by solutions sterilized with as- , ORIG TET^ N / cme vO... oP. Proc Soc Exptl DATE _ ASSTR REP 1 - be _ oP . DATE | | | | 1 It was demonstrated that filtering responses of the through an asbestos type filter disc will PITSURG^ organism to that solution This change the local have pulled off the disc and are present the reaction is due to particles and fibers in eosinophilia appeared following injections of asbestosfiltrate at the time of injection A similar paper fibers Ground and and tale but not following silica glass mica produced only slight increases in the cotton or number of local eosino- INSTIUTE understanding to better of the effects of a solution upon an organism -- Biol Absts Ve ney MELON - DATE - PURPOSE I CONE cee: CLASSIFIED BUBJECT PA TITLE Functional abnormalities of industrial pulmonary fibrosis PA ORIG REF1 PS 17 burgh burgh VOL : DATE ABETH REFS : . VOL 7, Arch 17 burgh Health | 11 183-211 burgh Mar. 155 a | burgh Pulmonary | The Functional Abnormalities of Industrial _ Fibrosis G. W. author describes the function of respiratory and cardiocirculatory Wright circulatory systems in its various He shows how the results of these methods indicate silicosis stages The typical appearances and clinical tosis are then described and contrasted with those conditions in asbes- there is a in silicosis gross correlation between intensity and duration of As silicosis exposure but no and may lead to confusion A further coexistence of the diseases Both difficulty in diagnosis is the frequent + may be roentgenologically manifest recognizable physical impairment without , FORM DATE ; STAMINED STAMINED , 141 . PURPOSE ABSTRACT BLANK FOR GENERAL USE ; CONT Dee 29 77 roam ae nr) FEL owing ct ee Siw ewome. se oe ORO nn, TORT FILE FELLowing FELLowing FELLowing NUMBER aoe. : FAS NUMac: | auton, P, Cartier, . P. | : PA Aer 3 onic. AUTHORI ee Some clinical observations . of asbestosis mine and mill workers. DATE Gre. YOL yealen 11 183-211 AGSTP AGSTP ARFS ee, . OE. os en. Arch. Mar. 155 Clinical | " Some Observations of Asbestosis Mine observed Statistics Mine Mill Workers Workers 7 Clinical comments are Some Statistics presented on 128 cases of P. and comments period of eight years author importance have been In his experienceasbestosis asbestosis asbestosis asbestosis asbestosis Statistics without without clinical diagnosed by the pathologist previous previous of importance roentgenologist The wide discrepancy appreciation appreciation clinical confusion detection of asbestosis by different confusion especially before before a compensation board The pathologists leads to obvious detection a compensation limitations of the table employees shows that status status of cases is good and that employees early early stages of asbestosis able able to work 59 employees remaining remaining e asbestosis correlation without discomfort For clinical cases of asbestosis between degree of asbestosis and status been found no clinical status has been acaters found, oe. oare sae EXAMINED . AY. Tom SEARCHI me AUSTRACT AUSTRACT ABSTRACT BLANK FOR {ae GENERAL USE use . 1s fl ee aa ON es ke aes ee Oo ae me, Om TOA rag MoE UTS mare Fans gale. Cs elias Wap e | 1 [ 183-211 Mar.155 | I i= Arch Dcc Health _- URGH Asbestosis as Differentiated from | | | Other Pneumoconioses O. ; A. Sander which may cause irreversible irreversible harm to be thoroughly investigated investigated so that such INE wees INE be considered causes of the Poorly studied cases embarrassing to the physician but the patient Every obscure case should unfortunate situations do not arise ae - MELLON MELLON . ~ MELLON MELLON MEL ON DATE XAMINED wae 4 ae ry . PURPOSE DE SEARCHL ABSTRACT SEARCHL BLANK FOR GENERAL USE ( ( SEE SEE HAI ~ HAI CLASSIFIED SUBJECT , ~~. |" FELLOWSHIP 1185 9/56 185 185 9/56 9/56 NFC AUTHORI Pa pulmonary TITLE Som oe A, ot eee Ce a H. Bastenier H. mee. Sts. we Byte he Se i ns Denolin A. de Coster and M. A study of respiration in asbestosis KUMBER | NFC . Englent FILE NUMBE 752 752 752 Arch maladies - Presburon INSTIUTEINSTITUTE MELLON MELLON MELLON profess 6 profess am 546-553 16 __. 1955 | ee el se oD oP 11) eee meee | Bull Hyg - - 31 544 | 5/56 ome. a oe eee, In order to test the be. be were closely studied The respiratory value of lungs affected with asbestosis 1,000 to 2,000 seven men and two women had been exposed to nine cases particles per cu m for 18 to 30 asbestos dust symptoms of asbestosis with troublesome years The patients displayed defiaite like ground glass extending over both cough and dyspnea and all showed ray shadows definite reduction was found in lungs No tubercle bacilli were found in Breathing factory however vital capacity but the maximum any case A was accelerated expiratory volume was satis- by hyperventilation At sufficient and satisfactory hut on exertion dyspava rest breathing was ing to the pathological lesions in the lungs These appeared varying considerably accord- ent from those seen in other functional changes were in no Varying no special strain cases of pneumoconiosis was thrown upon the heart way differ- emphyserna was found but men MELLON -- Coad from Bull Hyg MELLON MELLON | SXAMINED SXAMINED [" BYI FFR PUPPOSE OF SEARCHI . ABSTRACT SLANK FOR GENERAL USE . CONT'D CONT'D nner ; fate cn aeren wnrrsie fee ( N ~~ j C C 2 a o o nn H CLASSIFIED SUBJECT 5/55 | 1572 5/55 5/55 eee ire SHE Pr et tea tam Wet Bee tor FELLOWSHIP | FILE NUMBER | 752 ~ FC FC - 752 no AUTHOR A. J. Lanza . TITLE Recent trends in industrial health ; PA PA , GRIG REFS : VOL HEP9.1 PP DATELESTA eo VOL ae - DATE Health Mar. '55 | | URANI Arch Occ er es _ 2 ss ~~ _ a : 11 183-211 URANI Health URANI | _ somes meme Recent Trends in Industrial A. J. This short address serves as an introduction to the sizes the need of continued progress in the study of Lanza scientific papers dust diseases and empha- INSTITUTE INSTITUTE INSTITUTE INSTITUTE INSTITUTE Mellon i} Mellon Mellon Mellon | DATE EXAMINED PURPOSE SEARCHI GENERAL OF ABSTRACT BLANK FOR _ USE CONT'D a - - ewe ee mee Se a mee eet ie MOS ee om time emmo FELLOWSHIP NUMBER FILE FILE NUMBER TVRs rt tee cee me ee oe et ney CD FC ove 752 | - .. Lanza Wright Lynch AUTHOR Aze Gem Health Health Health Bristol Cartier , . TITLE . Symposium on Pa occupational diseases of the lungs , ORIG REF6 if. grou grou grou ee Occ grou Arch grou Health grou ea vou. 11 183-211 DATE Sa AGSTR REF | 11 | 183-211 Mar.155 Mar.155 VOL VOL mp, temo acme Symposium on Occupational Diseases of the 183-211 Mar. 1955 Lungs Arch Ind | Health 11 - o OATE coopera- tion with the Institute of Industrial Mas achuset s in Medicine of New York University at Gradu- papers Asbestosis is the main theme of the MELION MELION It MELION MELION 3 ae DATE EXAMINED H ; RxU . . PURPOSE SEARCHI ABSTRACT SLANK FOR GENERAL USE CONT'D et tam+e | : 372 ! 372 155 ra $ 155 ly i! AUTHOR J. J. Bristol FILE NIlene FC 7 7 FC 7 752 TITLE = Roentgenologic aspects of silicosis and asbestosis , * ORIG REFS Arch JURGIL JURGIL ; Gec Health VOL PP. DATE 4801A ners | 1111 183-211183-21 Mar. 155 VOL | | mp. | 15)5 eee a Roentgenologic Silicosis Aspects of and J. Asbestosis Typical roentgenograms L. J. Bristol roentgenograms show the appearance of silicosis and of asbestosis in the three stages of cach and of silicosia with tuberculosis The functional ment in silicosis is due to diffuse obstructive impair- x in full expiration aids in eraphysema andray examination evaluating the presence or absence of this other On the other hand not all cases of asbestosis have a breathing probcloempmlicEaxtpiiroantio films are not of much value in impairment in determining the presence or absence ofresrpiratory espiratory asbestosis shothwedseeficnaitseesfuncStoimonealpersons with slight ray changes indicating silicosis impairment Thissituation does not occur M M f -- -- ---- ----, -- -- ---- ----, FORM | i " 1 DATE | ~ EXAMINED Qf Sx PURPOSE ABSTRACT BLANK FOR GENTRAL UST CONT'D CONT'D ees c oN - auf v7 Foun . t] t oo AUTHOR: . +4 i ! one | 1 t R, Doii, sree. . : Te | FELOWSHIP FELLOWSHIP Message 1 HUMBER HUMBER ~_ NUMOCA NUmaca ! | NFC 752 Pa. PITSBURgn MTueE, Ins INSTIUTE L ON Cr * ve) MEL ON AUTHORI Doil from lung cancer asbestos asbestos workers MIG. ners, meee Ob ORIG REFS ind, Apr Brit [ | Apr | A@ETRacr., wens Med, 12 ew, . Apr 81-86 8 AUSTR 155 AUSTR e REPS REPS von. Pe, Ba L113 Mortality from Lung Cancer in Mortality Mortality from 81-86 Asbestos Workers Apr. 195 Doll Doll J. J, Date In necropsies of 105 asbestosiworks persons who had been lung cancer was found in 18 employed cases cases instances employed at asbestosiworks was also found These 15 least asbestosis years before 1923 when dust workers were become effec- effec- nine years additional 113 men control regulatiregulations ons asbestos who had been to dust mortality was tive tive years were followed up and their compared with for that the whole male population population mortality deaths occurred with Thirty that group whereas 15.4 were deaths entirely due to excess deaths from expected lung cancer The 0.8 expected and from . . 1 against 0.8 expected) and CONTO . DATE av, : PURPOSE : OF SEARCHSEArRCHr BLANK AGSTRACT BLANK FER Guise ung PONTO. Sr, Digest EX 185 b Te ed ate eee ver te e, cardiovascular respiratory respiratory respiratory and cardiovascular cardiovascular cardiovasculcaarrdiovascular cardiovascularcardiovascular cardiovascular cardiovascular cardiovascular on ee ees associated For For the the For For For data data data it it it of cancer cancer cancer is a specifsipcecifiscpecific specific specificspecific cancer is hazard employed asbestos years risk risk among among among men men employed employed risk among employedmployed for ofof ten times times times that that that that experienced experienced experienced hazard hazard employed for experienced experienced experienced experienced of asbestosasbestos asbestos 20 years byby thethe become progressively workersworkers workers asbestos or general general gen ral general and workers workers and and more more more has population population population population po ulation old dusty conditions conditions concluded that that lung lung the thatbo nboon boon . average average average average the the average averageaverage order order order of has The risk risk risk has - tge -1- as i$ . i : | % i + 6 .G t ee es 1 : i t t i ! 1 we t t :: 1 og. ' Seem ee pene : a . | ^' 3 - ! I pce ewe ed ar } | : - - . | i t , : e { { t ne t H ' , q f { ; : $ ' t ft. > er ie ~ e . we Hd i ' Hi ! : ' t : 1 i ' : !i 4 ' ne ' en, e - : 1 i : Pulmonarydisability inasbestosworkers 1298-203'55 Respiratory neon nee STS disease experience among several thousand male. and female asbestos workers in the United States andCanada is reported Of all workers exposed to the fibers very few develop asbestosis This insidious exposur,e disease is in onset and progresses slowly with continued _ respiratory causing embarrassment and cardiac failure Expansion the lung is difficult and thereis impaired gas transfer through the lung Dif- pattern iL fuse obstructive emphysema isnot common The typical ray ea pneumoconioses surveyof cannobte confused with other An ray ' 708 employees in a milling operation showed that the majority had- - 7 bo normal raypatterns that ten or more years of exposure were nec- yoo to were essary produce ray changes and that no cases of asbestosis foundwho had worked less than 20 years in the dust The incidence and - > duration of nonoccupational respiratory disease were not increased by exposure Asbestos does not predispose to tuberculosis nor does it - aggravate an apparently healed lesion There are several reasons for : different relationship ofasbestosis t opinions expressed concerning the of ee different opinions opinions . oom concerning concerning ew the | : . - ae : odes:Pike shia ao a . ls ten i rer Site Oe er e ae: bebe omens tam . e ee . . . . i a | * ~_ > v : woe . yO note j _- . a i . a es + . : : ry . . . ~+e : wees i . : . 2 7 - . : eo So ee L t ey Cer . are ee ee . Sore an me ess . eo are 2 See ae . Femme a : oe. 4 oe : : ce wee . . . ne is 4 : - 7 ~ be. pean . weed . : ae r] . 7 2 a eee . a i - co ae i _. a Fi ee . ioe) | . , . moo . 4 . morn be ne H . wee gw ee > $e -. Sie one ee . ao . $ : : ar Hoe - 2 woe ee et t : t. $a Qing : ore ae : . . : q t : +O Py e : : 4 . . : . se : : - . ao . . : : : : ' , o_ ' : : oa : . . ee i : . .t { : m ee el . we : : . - . I i : j . , oa } bets : rere ees |.. . * : 4 Hi ee : pee ee ee ne cee : i : . - t . Boils 4 ae : . ? oa . . : : . wean s . : : ; : . + ows ewe -. red 7 : ; . . as st ee , . ! o bomen . . aah omer : nba = 4 : : : . : ce < . se . ve ca rr . ow .f a . . . . eS _ . i . . @ oe. * - . . . * < : CLASSIFIED BEJECT AUTHOR 8/57 8/57 ! M. Navratil V. Krecek and L. Cvachova NUMBER PA TITLE Results of functional respiratory and circulatory tests of workers exposed exposed to asbestos dust over a number of years ORIG REPS Czech VOL 1329-333 DATE _ _.. ACSTR REFS.1 VOL PP DATE Pracovni Lekarstvi 8 1956 Hyg | | 1329-333 Bull ee ew ee erent we ee bene. 1329-33 A. 32460 32460 5/57 ABSTRACT . mie eee oO dust Sixty workers exposed to asbestos were classified according to severity of PITSBURN asbestosis and according to age They were subjected to functional tests for expiration and for ventilatory coefficients and to prolonged electrocardiography In the over 50 age group quite apart from all radiological data a drop in vital capacity is found due not merely to age but also to emphysema which was detected in 19 patients The ventilation coefficients in the asbestosis and early asbestosis limits groups were within normal In those with advanced asbestosis there was a distinct drop in the ventilation coefficients INST UE due to fibrosis and associated pathological conditions The differences in the carbon dioxide ventilation coefficients and in the vital capacity figures were on the limit of signifi 6, cance Hypertrophy of the right heart was present in two subjects with advanced asbestosis 8.0 10M MELON ... Cond from Bull Hyz . vr TY FORM DATE +. EXAMINED ET FFR PURPOSE OF SEABEN SEABEN ~.. ABSTRACT BLANK FOR GENERAL USE CONT'D ene CLASSIFIC SUBJECT -- i 190 190 AUTHOR 9/50 Se i canine 9/50 Tre Nae RIES 0 A tag, ot SE H. Bohlig and G. Jacob ee re ee Pee oe FELLOWSHIP | NUMBER FILE NUMBER tee EM eee. er, | NFC 753 Tee ee . * vemee Pa TITLE New viewpoints on pulmonary cancer in asbestos workers ^NPSITTISBUUrTgiE Deut GerWmoachnschrc+ 81 Feb. 17 56. Assn 1161/916 1161/916 116/30/566 /30/56 a 8-68 Melon IOM ORIG RESS med (C02 VOL we Wochschr . _ DATE 231- AOSTR AIFS J. Am Lee Med VOL PP, Visa ee one = .2.3.3 Tobe TT tee. meee 1161/916 hypotheses . The following distinguishing features have been ee oes has been recognized as an attributed to the lung cancer that dence 2 development occupational disease of asbestos workers 1 increased inci- at an early age 3 dependence on duration of dust 4 a latent period between onset of exposure to asbestos the localization 6 the histological exposure and the appearance of the cancer 5 structure and 7 the multicentral origin The authors discuss each of these points and show that there is little clear these assumptions with exceptions noted evidence to support any of Women workers in the asbestos industry have lung cancer more often and at an earlier age than do other women but the true of men Malignant growths of the pleura seem to same is not than in other persons The multicentral occur more often in asbestos workers to cobalt and to chromates development is observed also in workers exposed The study of the pathogenesis is still in the and the theory of mechanical pathogenesis is given most state of asbestos bodies are always found in the consideration Microtraumas and authors feel that this does pulmonary cancers of asbestos workers but the not necessarily prove the mechanical factors that speak against a purely mechanical theory They cite several concede that the pathogenesis of asbestos canter development of called asbestos warts proves the but they asbestos on human tissues irritating effect of DATE tee cee -- Cond from J. Am Med Assa , DATE , CLAMINEDI ev, FFR PURPOSE OF SEARCH , COCONTO NTO ABSTRACT BLANK FOR GENERAL Use Se Be eo te ee ee we my FILE NUM e. 6.89 we 6.89 5 ; C 71 FORM AUTHOER. R. Wiese and W. E. B. Hall TITLE Asbestosis report of a case PA ORIG RES Chest Diseases of 1229 1229 DATE Aug. ABSTR REFU.1 VOL ee rm me ae 30 230 156 ene fatal The history and autopsy findings in a case of asbestosis are reported Conditions described include absence of the middle lobe of the right lung greatly ea- PITSBUrgh larged heart wide spread sharply demarcated development of fibrosis and degenera tion of collagen in extensive irregular fields These and other conditions are described fally Fine needles representing the original asbestos fibers were seen Small asbestos bodies were seen in a few areas of focal fibrosis although they had not appeared in the INSTUE sputum MELON DATE FXAMINED ST FFR PURPOSE OF SEARCHI ABSTRACT BLANK FOR GENERAL USE CONT a ( : 9 - : 2 . ! a we IALE an, > z ha ive wall Georg, a, fad : be 2! Georg and Moller calcification 1 insulation an. 7 3 mp 264 Sati DATE Bull tah ee a Hyg Hyg workers ~) ate ~n Works: ts, 2 ML, ou a/- nos aan r , Pa . =, ao Oy z POM to obliterate combined MELEGEN Sample - MELEGEN F LAte "FA eeie ele.Sol ete ee ov, adhesions seen which the mottling indicative were adhesions pleura were so and widespread extensive extensive thickeninstances some ascribed unusual obliterate may calcium changes magnesium presence of fibrogenin asbestos asbestos dust and magnesium did the presence presence fibrogenin asbestos quartz , not reveal reveal alpha The The instance; bilateral pleural changes changes series definitely quartz points an definitely pleural the present changes if the Cord from VScriheg Hyg PTesent dust, Hyg Series Tke Celinitel -* Cong,+g .Picts in an *29r2 Buy : Hyg, , OT t PR ABSTRACT Ne IS ae, ABS t Racy MMianer ray SENeA,, Weg COnt yg. ae oe. CLASSIFIED SUBJECT .. aoe - - -- ~ ame. oe rs a re te. ee - { FELLOWSHIP FILE NUMBER | NUMBER NUMBER . ANTROR M. Lynch F. A. Melver and J. R. Cain TITLE PA Pulmonary tumors in mice exposed to asbestos dust ORIC REPS VOL DATE ABSTR REPS Ind 15207-214 15207-214 - TO .. OR wee tees mee wee VOL an - or, kw Arch Health 15207-214 | Mar57 ABSTRACTI wwe ome on. , Mice of a selected strain AC F were exposed to a dusty atmosphere Pitsburgh containing asbestos floats of a type used by others experimentally cubic foot The largest single experimental at 150 to 500 million particles per group consisted of 127 animals killed at 19 months after exposure for 17 months This was group compared with 222 control animals. lung tumors were demonstrated microscopically in 46 of the dusted mice and in 18 pulmonary tumors the 36 of the controls Multiple were demonstrated in of dusted animals and in % of the control animals No significant histologic or cytologic difference was Insti ute observed between tumors in the two groups No clear proof of malignancy in any of the lung tumors studied The was found authors have been unable to demonstrate any of the carcinogenicity of asbestos under the conditions of the experiment but proof the increased incidence of multiple lung tumors in dusted animals must be regarded as mice accentuation by the inhalation of asbestos dust of a possi- bility tendency Mel on an existing tendency to develop lung tumors Future experiments with asbestos should include the use of larger animals prob- lems ably monkeys The equivocal nature of this report does not answer the questions raised by accumulating clinical evidence that asbestosis is strongly associated with and therefore is summary a possible cause of pulmonary carcinoma in man -- Adapted from authors o . . . DATE TXANIMEDI : _ , + - 18 See av FFR PURPOSE PURPOSE Dewees cee te OF BEARCH ey e CONTO ABSTRACT BLANK FOR GENERAL USE DATE ----- Primary CLASSIFIED SUBJECT FELLOWSHIP FILE NUMBE AUTHOR TITLE E. Sartorelli Severe asbestosis with capillary block syndrome PA ORIG ADS Italian Med lavoro VOL PP DATE 48 358-362 T 1957 ee a + tween comnts ABSTR REFS.1 Bull Hyg ecm em mentee VOL $ | ce tet -, 969 DATE 157 pct ABSTRACTI e.- The aged a case of severe asbestosis in a man reports 57 who was em- author ployed for seven years in a very dusty asbestos factory Three years after commencing PITSBURGH work the patient complained of dyspnea on exercise with slight sputum the condition be- came progressively worse and finally he was sent to a sapatorium as a case of combined tuberculosis and asbestosis with a disability of 50 After two years in spite of his res- he started work as a general laborer and was admitted to the author's piratory symptoms clinic three years later with a recurrence of chest symptoms No tubercle bacilli were found ray of the chest showed intense reticulation especially in the medio regions INST UE small zones of fibrosis in the right clavicular area and thickening of the pleura at the left base Tests of respiratory function showed dyspnea on repose and markedly so on ex- Mel on ercise and while respirometry gave only slight alteration from normal the oxygen satur ation was only 90 The diagnosis of advanced asbestosis was made on account of the marked respiratory insufficiency absence of tuberculosis increased erythrocyte sedimentation rate -- Cond from Bull Hyg and hypergammaglobulinemia DATE EXAMINEDI . ey . ; JM PURPOSE OF SEARCHI me ee ee ABSTRACT BLANK FOR GENERAL USE . CONT'D ee ee ee ee: oe eal wee - owen ere